Page last updated: 2024-10-20

thiamine and Polyneuropathies

thiamine has been researched along with Polyneuropathies in 31 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.

Research Excerpts

ExcerptRelevanceReference
" Although thiamine deficiency is a possible cause of this neuropathy, the pathogenesis still remains to be clarified."7.71Postgastrectomy polyneuropathy with thiamine deficiency. ( Hattori, N; Hirayama, M; Ichimura, M; Ito, H; Ito, S; Koike, H; Misu, K; Nagamatsu, M; Sasaki, I; Sobue, G, 2001)
" Although thiamine deficiency is a possible cause of this neuropathy, the pathogenesis still remains to be clarified."3.71Postgastrectomy polyneuropathy with thiamine deficiency. ( Hattori, N; Hirayama, M; Ichimura, M; Ito, H; Ito, S; Koike, H; Misu, K; Nagamatsu, M; Sasaki, I; Sobue, G, 2001)
"The authors report a case of beriberi due to a deficit in thiamine, which became apparent in a young Chinese woman with polyneuropathy, distal oedema and epigastralgia."3.68[A case of beriberi on the threshold of the year 2000]. ( Carpinteri, F; Renzi, A; Sampalmieri, M; Servi, M, 1992)
"Erythrocyte transketolase activity (ETKA) and the effect of adding thiamine pyrophosphate have been measured in a group of 27 healthy individuals and in 37 patients diagnosed as having diabetes mellitus, anemia, polyneuritis, or malnourishment secondary to vascular disease of the brain."3.65The transketolase assay of thiamine in some diseases. ( Kjosen, B; Seim, SH, 1977)
" Currently, there are only few pathogenetically oriented pharmacotherapies for DSPN, one of which is benfotiamine, a prodrug of thiamine with a high bioavailability and favourable safety profile."3.11BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy. ( Al-Hasani, H; Bönhof, GJ; Herder, C; Icks, A; Knebel, B; Kuss, O; Reule, C; Roden, M; Sipola, G; Strassburger, K; Strom, A; Wollmann, JC; Ziegler, D, 2022)
"Peripheral polyneuritis is not a disease entity but a mystery."1.23Evaluation of therapy of peripheral polyneuritis. ( IVES, ER, 1950)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199020 (64.52)18.7374
1990's1 (3.23)18.2507
2000's3 (9.68)29.6817
2010's3 (9.68)24.3611
2020's4 (12.90)2.80

Authors

AuthorsStudies
Samur, BM1
Gümüş, G1
Canpolat, M1
Gümüş, H1
Per, H1
Cağlayan, AO1
Bönhof, GJ1
Sipola, G1
Strom, A1
Herder, C1
Strassburger, K1
Knebel, B1
Reule, C1
Wollmann, JC1
Icks, A1
Al-Hasani, H1
Roden, M1
Kuss, O1
Ziegler, D2
Iravani, S1
Kazemi Motlagh, AH1
Emami Razavi, SZ1
Shahi, F1
Wang, J1
Hou, L1
Sun, W1
Afshari Fard, MR1
Aghili, M1
Karimi, M1
Rezaeizadeh, H1
Zhao, B1
Stirban, OA1
Zeller-Stefan, H1
Schumacher, J1
Gaus, W1
Schuerholz, T1
Pop-Busui, R1
Tsao, WC1
Ro, LS1
Chen, CM1
Chang, HS1
Kuo, HC1
Gowda, VK1
Srinivasan, VM1
Jehta, K1
Bhat, MD1
STEPHEN, EH1
Kempler, P1
Ishibashi, S1
Yokota, T1
Shiojiri, T1
Matunaga, T1
Tanaka, H1
Nishina, K1
Hirota, H1
Inaba, A1
Yamada, M1
Kanda, T1
Mizusawa, H1
KANTARJIAN, AD1
SHAHEEN, AS1
EBRAHIM, GJ1
HADDOCK, DR1
SCHILDKNECHT, O1
MEISTER, P1
Nakamura, K1
Roberson, ED1
Reilly, LG1
Tsao, JW1
IVES, ER1
Caster, WO1
Meadows, JS1
Meyer, JG1
Neundörfer, B1
Rethel, R1
Walker, G1
Bayerl, J1
Majoor, CL1
de Vries, LA1
Koike, H1
Misu, K1
Hattori, N1
Ito, S1
Ichimura, M1
Ito, H1
Hirayama, M1
Nagamatsu, M1
Sasaki, I1
Sobue, G1
Dreyfus, PM1
Kjosen, B1
Seim, SH1
Sampalmieri, M1
Carpinteri, F1
Renzi, A1
Servi, M1
Schiffter, R1
Pluvinage, R1
Martynov, IuS1
Gaft, PG1
Malkova, EV1
Koshelov, IuI1
Kuznetsov, VN1
Francesconi, G1
Mellina, S1
Charles, OW1
Roland, DA1
Edwards, HM1
Luvarà, A1
Victor, M1
Selaimen, F1
da Motta, PE1
Cunha, DF1
Duché, G1
Perles, R1
Boettcher, D1
Stoerger, R1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Efficacy of Social Media Assisted Home-based Transcutaneous Electrical Acupoint Stimulation on Symptoms Associated With Chemotherapy Induced Peripheral Neuropathy in Patients With Breast Cancer[NCT05904340]86 participants (Anticipated)Interventional2023-07-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for thiamine and Polyneuropathies

ArticleYear
Clinical and genetic studies of thiamine metabolism dysfunction syndrome-4: case series and review of the literature.
    Clinical dysmorphology, 2022, Jul-01, Volume: 31, Issue:3

    Topics: Brain Diseases; Exome Sequencing; Humans; Mitochondrial Membrane Transport Proteins; Mutation; Polyn

2022
Thiamine and the nervous system: an overview.
    Journal of nutritional science and vitaminology, 1976, Volume: 22 SUPPL

    Topics: Action Potentials; Animals; Brain Diseases; Central Nervous System; Humans; Membranes; Nervous Syste

1976
[Review on antivitamins B1].
    Acta vitaminologica et enzymologica, 1970, Volume: 24, Issue:1

    Topics: Acetylcholine; Animals; Fruit; Heart; Lactobacillus; Methods; Mice; Muscles; Nerve Tissue; Phenols;

1970

Trials

3 trials available for thiamine and Polyneuropathies

ArticleYear
BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy.
    BMJ open, 2022, Feb-03, Volume: 12, Issue:2

    Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Humans; Polyneuropathies; Qua

2022
Effectiveness of Acupuncture Treatment on Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized, Assessor-Blinded, Controlled Trial.
    Pain research & management, 2020, Volume: 2020

    Topics: Acupuncture Therapy; Adult; Analgesics; Antineoplastic Agents; China; Female; Gabapentin; Humans; Ir

2020
Treatment with benfotiamine in patients with diabetic sensorimotor polyneuropathy: A double-blind, randomized, placebo-controlled, parallel group pilot study over 12 months.
    Journal of diabetes and its complications, 2020, Volume: 34, Issue:12

    Topics: Diabetes Mellitus; Diabetic Neuropathies; Double-Blind Method; Humans; Pilot Projects; Polyneuropath

2020

Other Studies

25 other studies available for thiamine and Polyneuropathies

ArticleYear
Non-alcoholic Wernicke's encephalopathy with cortical involvement and polyneuropathy following gastrectomy.
    Metabolic brain disease, 2017, Volume: 32, Issue:5

    Topics: Aged; Cerebral Cortex; Female; Gait Disorders, Neurologic; Gastrectomy; Gastric Bypass; Humans; Magn

2017
Bilateral Striatal Necrosis with Polyneuropathy with a Novel SLC25A19 (Mitochondrial Thiamine Pyrophosphate Carrier OMIMI*606521) Mutation: Treatable Thiamine Metabolic Disorder-A Report of Two Indian Cases.
    Neuropediatrics, 2019, Volume: 50, Issue:5

    Topics: Child, Preschool; Corpus Striatum; Female; Humans; India; Male; Metabolic Diseases; Mitochondrial Me

2019
Thiamine in pink disease.
    The Medical journal of Australia, 1948, Jul-31, Volume: 2, Issue:5

    Topics: Acrodynia; Humans; Polyneuropathies; Thiamine

1948
[Treatment of neuropathies].
    Orvosi hetilap, 2010, Jan-10, Volume: 151, Issue:2

    Topics: Adjuvants, Immunologic; Adrenergic Uptake Inhibitors; Amines; Analgesics; Antioxidants; Capsaicin; C

2010
Reversible acute axonal polyneuropathy associated with Wernicke-Korsakoff syndrome: impaired physiological nerve conduction due to thiamine deficiency?
    Journal of neurology, neurosurgery, and psychiatry, 2003, Volume: 74, Issue:5

    Topics: Acute Disease; Adult; Axons; Humans; Korsakoff Syndrome; Male; Middle Aged; Neural Conduction; Polyn

2003
METHYL BROMIDE POISONING WITH NERVOUS SYSTEM MANIFESTATIONS RESEMBLING POLYNEUROPATHY.
    Neurology, 1963, Volume: 13

    Topics: Bromides; Folic Acid; Humans; Hydrocarbons, Brominated; Neurology; Physical Therapy Modalities; Poly

1963
POLYNEUROPATHY OF PROBABLE NUTRITIONAL ORIGIN IN DAR-ES-SALAAM, TANGANYIKA.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1964, Volume: 58

    Topics: Ataxia; Deficiency Diseases; Humans; Muscular Diseases; Niacin; Nicotinic Acids; Nutrition Surveys;

1964
[PERIPHERAL POLYNEUROPATHY ASSOCIATED WITH SUBUREMIA AND NITROFURANTOIN TREATMENT].
    Schweizerische medizinische Wochenschrift, 1964, Mar-21, Volume: 94

    Topics: Neuritis; Nitrofurantoin; Peripheral Nervous System Diseases; Polyneuropathies; Thiamine; Toxicology

1964
Polyneuropathy following gastric bypass surgery.
    The American journal of medicine, 2003, Dec-01, Volume: 115, Issue:8

    Topics: Adult; Anastomosis, Roux-en-Y; Female; Gastric Bypass; Humans; Injections, Intravenous; Polyneuropat

2003
Evaluation of therapy of peripheral polyneuritis.
    California medicine, 1950, Volume: 73, Issue:4

    Topics: Folic Acid; Humans; Neuritis; Niacin; Polyneuropathies; Pyridoxine; Riboflavin; Thiamine; Vitamin B

1950
The three thiamin requirements of the rat.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1980, Volume: 50, Issue:2

    Topics: Animals; Body Weight; Cardiomegaly; Dose-Response Relationship, Drug; Heart Rate; Male; Nutritional

1980
[Levels of vitamin B1 and B12 and of folic acid in alcoholic polyneuropathy (author's transl)].
    Der Nervenarzt, 1981, Volume: 52, Issue:6

    Topics: Adult; Alcoholism; Folic Acid; Humans; Hypesthesia; Muscle Cramp; Neural Conduction; Polyneuropathie

1981
[The development of cardiac beriberi with polyneuritis after protracted use of large amounts of magnesium trisilicate. An unpublished observation by Dr. J. G. G. Borst].
    Nederlands tijdschrift voor geneeskunde, 1980, Aug-23, Volume: 124, Issue:34

    Topics: Antacids; Beriberi; Heart Failure; Humans; Male; Middle Aged; Polyneuropathies; Self Administration;

1980
Postgastrectomy polyneuropathy with thiamine deficiency.
    Journal of neurology, neurosurgery, and psychiatry, 2001, Volume: 71, Issue:3

    Topics: Activities of Daily Living; Adult; Aged; Biopsy; Diagnosis, Differential; Disease Progression; Femal

2001
The transketolase assay of thiamine in some diseases.
    The American journal of clinical nutrition, 1977, Volume: 30, Issue:10

    Topics: Anemia, Macrocytic; Anemia, Pernicious; Apoenzymes; Diabetes Mellitus; Diabetes Mellitus, Type 1; Er

1977
[A case of beriberi on the threshold of the year 2000].
    La Clinica terapeutica, 1992, Volume: 141, Issue:10

    Topics: Adult; Beriberi; China; Female; Humans; Italy; Polyneuropathies; Thiamine

1992
[Bilateral horizontal gaze paralyses. Clinical analysis of three cases].
    Zeitschrift fur Neurologie, 1971, Volume: 200, Issue:4

    Topics: Abducens Nerve; Adult; Alcohol Amnestic Disorder; Ataxia; Diplopia; Female; Humans; Male; Middle Age

1971
[Study of the therapeutic action of a combination of vitamins B1, B6 and hydroxocobalamin in large doses].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1968, Jan-20, Volume: 44, Issue:4

    Topics: Adult; Aged; Anemia; Brain Diseases; Epilepsy; Facial Paralysis; Fatty Liver; Female; Hemiplegia; He

1968
[Peripheral nervous system lesions in diseases of the digestive organs].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:11

    Topics: Adolescent; Adult; Arachnoid; Celiac Plexus; Cholecystitis; Chronic Disease; Colitis; Duodenal Ulcer

1974
[Clinical trial of a new coenzymatic complex (Ro 8-0743-4)].
    La Clinica terapeutica, 1972, Aug-15, Volume: 62, Issue:3

    Topics: Adult; Aged; Anorexia Nervosa; Cobamides; Coenzymes; Drug Combinations; Evaluation Studies as Topic;

1972
Thiamine deficiency identification and treatment in commercial turkeys and Coturnix quail.
    Poultry science, 1972, Volume: 51, Issue:2

    Topics: Animals; Female; Folic Acid; Injections, Subcutaneous; Male; Pantothenic Acid; Polyneuropathies; Pou

1972
Deficiency diseases of the nervous system secondary to alcoholism.
    Postgraduate medicine, 1971, Volume: 50, Issue:3

    Topics: Alcohol Amnestic Disorder; Alcoholism; Amblyopia; Beriberi; Cerebellar Diseases; Deficiency Diseases

1971
[Use of B6, B1, B12 vitamins in polyneuritis due to the use of isonicotinic acid hydrazine].
    Hospital (Rio de Janeiro, Brazil), 1970, Volume: 77, Issue:2

    Topics: Adult; Female; Humans; Hydrazines; Injections, Intramuscular; Isoniazid; Isonicotinic Acids; Male; M

1970
[A new treatment for alcoholic polyneuritis].
    La Presse medicale, 1970, Nov-07, Volume: 78, Issue:47

    Topics: Alcoholic Intoxication; Arginine; Humans; Polyneuropathies; Pyruvates; Thiamine; Thiamine Deficiency

1970
[Clinical experiences with Neurogrisevit in neurologic diseases].
    Die Medizinische Welt, 1966, Nov-26, Volume: 48

    Topics: Facial Paralysis; Humans; Hydroxocobalamin; Polyneuropathies; Pyridoxine; Thiamine; Trigeminal Neura

1966