thiamine has been researched along with Neuroblastoma in 16 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Culture of neuroblastoma cells in a medium of low-thiamine concentration (6 nM) and in the presence of the transport inhibitor amprolium leads to the appearance of overt signs of necrosis; i." | 7.69 | Thiamine deficiency--induced partial necrosis and mitochondrial uncoupling in neuroblastoma cells are rapidly reversed by addition of thiamine. ( Bettendorff, L; Goessens, G; Grisar, T; Sluse, F; Wins, P, 1995) |
| "When neuroblastoma cells were transferred to a medium of low (6 nM) thiamine concentration, a 16-fold decrease in total intracellular thiamine content occurred within 8 days." | 7.69 | Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors. ( Bettendorff, L; Bureau, M; Goessens, G; Grisar, T; Laschet, J; Sluse, F; Wins, P, 1995) |
| "We recently showed that thiamine uptake by neuroblastoma cells is mediated by two saturable transport system: the first with high affinity for thiamine (Km = 35 nM) is blocked by veratridine; the other, with low affinity is blocked by Ca2+." | 7.69 | Thiamine homeostasis in neuroblastoma cells. ( Bettendorff, L, 1995) |
| "Thiamine transport in cultured neuroblastoma cells is mediated by a high-affinity carrier (KM = 40 nM)." | 7.69 | The compartmentation of phosphorylated thiamine derivatives in cultured neuroblastoma cells. ( Bettendorff, L, 1994) |
| "C-6 glioma and C-1300 neuroblastoma cells were cultured in thiamine deficient and control media." | 7.65 | Glycolytic metabolism in cultured cells of the nervous system. IV. The effects of thiamine deficiency on thiamine levels, metabolites and thiamine-dependent enzymes on the C-6 glioma and C-1300 neuroblastoma cell lines. ( McCandless, DW; Schwartz, JP, 1976) |
| "The effects of thiamine deficiency and of the antithiamine drug pyrithiamine on the C-6 glioma and the C-1300 neuroblastoma cell lines have been studied." | 7.65 | Glycolytic metabolism in cultured cells of the nervous system. III. The effects of thiamine deficiency and pyrithiamine on the C-6 glioma and C-1300 neuroblastoma cell lines. ( Lust, WD; Passonneau, JV; Schwartz, JP; Shirazawa, R, 1975) |
| "Culture of neuroblastoma cells in a medium of low-thiamine concentration (6 nM) and in the presence of the transport inhibitor amprolium leads to the appearance of overt signs of necrosis; i." | 3.69 | Thiamine deficiency--induced partial necrosis and mitochondrial uncoupling in neuroblastoma cells are rapidly reversed by addition of thiamine. ( Bettendorff, L; Goessens, G; Grisar, T; Sluse, F; Wins, P, 1995) |
| "When neuroblastoma cells were transferred to a medium of low (6 nM) thiamine concentration, a 16-fold decrease in total intracellular thiamine content occurred within 8 days." | 3.69 | Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors. ( Bettendorff, L; Bureau, M; Goessens, G; Grisar, T; Laschet, J; Sluse, F; Wins, P, 1995) |
| "We recently showed that thiamine uptake by neuroblastoma cells is mediated by two saturable transport system: the first with high affinity for thiamine (Km = 35 nM) is blocked by veratridine; the other, with low affinity is blocked by Ca2+." | 3.69 | Thiamine homeostasis in neuroblastoma cells. ( Bettendorff, L, 1995) |
| "Thiamine transport in cultured neuroblastoma cells is mediated by a high-affinity carrier (KM = 40 nM)." | 3.69 | The compartmentation of phosphorylated thiamine derivatives in cultured neuroblastoma cells. ( Bettendorff, L, 1994) |
| "C-6 glioma and C-1300 neuroblastoma cells were cultured in thiamine deficient and control media." | 3.65 | Glycolytic metabolism in cultured cells of the nervous system. IV. The effects of thiamine deficiency on thiamine levels, metabolites and thiamine-dependent enzymes on the C-6 glioma and C-1300 neuroblastoma cell lines. ( McCandless, DW; Schwartz, JP, 1976) |
| "The effects of thiamine deficiency and of the antithiamine drug pyrithiamine on the C-6 glioma and the C-1300 neuroblastoma cell lines have been studied." | 3.65 | Glycolytic metabolism in cultured cells of the nervous system. III. The effects of thiamine deficiency and pyrithiamine on the C-6 glioma and C-1300 neuroblastoma cell lines. ( Lust, WD; Passonneau, JV; Schwartz, JP; Shirazawa, R, 1975) |
| "Thiamine exhibited a lower IC50 value in both cell lines compared with DCA." | 1.40 | High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate. ( Berger, R; Hanberry, BS; Zastre, JA, 2014) |
| " We investigated the toxic effects of excess extracellular copper on motor neuronal cells expressing human mutant SOD1 (G93A), and evaluated the neuroprotective effects of energy metabolism intermediates or cofactors." | 1.33 | Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity. ( Kim, HJ; Kim, JM; Kim, M; Lee, KW; Park, JH; Sung, JJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Ramamoorthy, K | 1 |
| Yoshimura, R | 1 |
| Al-Juburi, S | 1 |
| Anandam, KY | 1 |
| Kapadia, R | 1 |
| Alachkar, A | 1 |
| Abbott, GW | 1 |
| Said, HM | 1 |
| Girgin, M | 1 |
| Isik, S | 1 |
| Kantarci-Carsibasi, N | 1 |
| Hanberry, BS | 1 |
| Berger, R | 1 |
| Zastre, JA | 1 |
| Darlington, WS | 1 |
| Pinto, N | 1 |
| Hecktman, HM | 1 |
| Cohn, SL | 1 |
| LaBelle, JL | 1 |
| Zhang, Q | 1 |
| Yang, G | 1 |
| Li, W | 1 |
| Fan, Z | 1 |
| Sun, A | 1 |
| Luo, J | 1 |
| Ke, ZJ | 1 |
| Kim, HJ | 1 |
| Kim, JM | 1 |
| Park, JH | 1 |
| Sung, JJ | 1 |
| Kim, M | 1 |
| Lee, KW | 1 |
| Szyniarowski, P | 1 |
| Bettendorff, L | 7 |
| Schweingruber, ME | 1 |
| Sluse, F | 2 |
| Goessens, G | 2 |
| Wins, P | 3 |
| Grisar, T | 2 |
| Bureau, M | 1 |
| Laschet, J | 1 |
| Volpe, JJ | 1 |
| Marasa, JC | 1 |
| Schwartz, JP | 2 |
| McCandless, DW | 1 |
| Lust, WD | 1 |
| Shirazawa, R | 1 |
| Passonneau, JV | 1 |
1 review available for thiamine and Neuroblastoma
| Article | Year |
|---|---|
A non-cofactor role of thiamine derivatives in excitable cells?
Topics: Animals; Chloride Channels; Electrophysiology; Ketoglutarate Dehydrogenase Complex; Models, Biologic | 1996 |
1 trial available for thiamine and Neuroblastoma
| Article | Year |
|---|---|
Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma.
Topics: Autografts; Child, Preschool; Female; Humans; Neuroblastoma; Skin; Stem Cell Transplantation; Thiami | 2015 |
14 other studies available for thiamine and Neuroblastoma
| Article | Year |
|---|---|
Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation.
Topics: Acinar Cells; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cytokines; Humans; Membrane Transpo | 2022 |
Proposing novel natural compounds against Alzheimer's disease targeting acetylcholinesterase.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Galantamine; | 2023 |
High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate.
Topics: Caspase 3; Cell Line, Tumor; Cell Proliferation; Dichloroacetic Acid; Glucose; Humans; Lactic Acid; | 2014 |
Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysi | 2011 |
Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity.
Topics: Amyotrophic Lateral Sclerosis; Cell Death; Cell Line, Tumor; Copper; Energy Metabolism; Free Radical | 2005 |
The antitrypanosomal drug melarsoprol competitively inhibits thiamin uptake in mouse neuroblastoma cells.
Topics: Animals; Cell Line, Tumor; Melarsoprol; Mice; Neuroblastoma; Thiamine; Trypanocidal Agents | 2006 |
Thiamine deficiency--induced partial necrosis and mitochondrial uncoupling in neuroblastoma cells are rapidly reversed by addition of thiamine.
Topics: Amprolium; Microscopy, Electron; Mitochondria; Necrosis; Neuroblastoma; Thiamine; Thiamine Deficienc | 1995 |
Thiamine deficiency in cultured neuroblastoma cells: effect on mitochondrial function and peripheral benzodiazepine receptors.
Topics: Adenosine Triphosphate; Amprolium; Animals; Cell Death; Culture Media; Isoquinolines; Lactates; Lact | 1995 |
Thiamine homeostasis in neuroblastoma cells.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chromatography, High Pressure Liquid; Homeostasi | 1995 |
Mechanism of thiamine transport in neuroblastoma cells. Inhibition of a high affinity carrier by sodium channel activators and dependence of thiamine uptake on membrane potential and intracellular ATP.
Topics: Aconitine; Adenosine Triphosphate; Amiloride; Animals; Batrachotoxins; Binding, Competitive; Biologi | 1994 |
The compartmentation of phosphorylated thiamine derivatives in cultured neuroblastoma cells.
Topics: Animals; Carbon Radioisotopes; Cell Compartmentation; Mice; Neuroblastoma; Temperature; Thiamine; Th | 1994 |
A role for thiamine in the regulation of fatty acid and cholesterol biosynthesis in cultured cells of neural origin.
Topics: Acetyl-CoA Carboxylase; Cell Line; Cholesterol; Fatty Acid Synthases; Fatty Acids; Glioma; Kinetics; | 1978 |
Glycolytic metabolism in cultured cells of the nervous system. IV. The effects of thiamine deficiency on thiamine levels, metabolites and thiamine-dependent enzymes on the C-6 glioma and C-1300 neuroblastoma cell lines.
Topics: Cell Line; Glioma; Glycolysis; Neuroblastoma; Pyruvate Decarboxylase; Thiamine; Thiamine Deficiency; | 1976 |
Glycolytic metabolism in cultured cells of the nervous system. III. The effects of thiamine deficiency and pyrithiamine on the C-6 glioma and C-1300 neuroblastoma cell lines.
Topics: Animals; Antimetabolites; Brain; Cell Division; Cell Line; Glioma; Glycolysis; Lactates; Mice; Neuro | 1975 |