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thiamine and Nerve Degeneration

thiamine has been researched along with Nerve Degeneration in 15 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
" Chronic alcoholism is usually associated with thiamine deficiency (TD) which is known to induce selective neurodegeneration in the brain."7.75Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase. ( Fan, Z; Ke, ZJ; Luo, J; Wang, X, 2009)
"Wernicke's encephalopathy (WE) is characterized by lesions in thalamus, hypothalamus (including mammillary nuclei), and inferior colliculi, results in serious disabilities, has an etiology of thiamine deficiency, is treatable with thiamine, and occurs most commonly with alcoholism."7.74Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study. ( Adalsteinsson, E; Bell, RL; Pfefferbaum, A; Sullivan, EV, 2007)
" Thiamine deficiency (TD) in rats is a model for the study of cellular and molecular mechanisms that lead to selective neuronal loss caused by chronic oxidative deficits."3.76Neurodegeneration in thiamine deficient rats-A longitudinal MRI study. ( Assaf, Y; Biton, IE; Dror, V; Eliash, S; Fattal-Valevski, A; Rehavi, M, 2010)
" Chronic alcoholism is usually associated with thiamine deficiency (TD) which is known to induce selective neurodegeneration in the brain."3.75Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase. ( Fan, Z; Ke, ZJ; Luo, J; Wang, X, 2009)
"Wernicke's encephalopathy (WE) is characterized by lesions in thalamus, hypothalamus (including mammillary nuclei), and inferior colliculi, results in serious disabilities, has an etiology of thiamine deficiency, is treatable with thiamine, and occurs most commonly with alcoholism."3.74Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study. ( Adalsteinsson, E; Bell, RL; Pfefferbaum, A; Sullivan, EV, 2007)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19905 (33.33)18.7374
1990's2 (13.33)18.2507
2000's6 (40.00)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mouton-Liger, F1
Rebillat, AS1
Gourmaud, S1
Paquet, C1
Leguen, A1
Dumurgier, J1
Bernadelli, P1
Taupin, V1
Pradier, L1
Rooney, T1
Hugon, J1
Bâ, A1
Ke, ZJ1
Wang, X1
Fan, Z1
Luo, J1
Dror, V1
Eliash, S1
Rehavi, M1
Assaf, Y1
Biton, IE1
Fattal-Valevski, A1
UMRATH, K1
Pfefferbaum, A1
Adalsteinsson, E1
Bell, RL1
Sullivan, EV1
Oliveira, FA1
Galan, DT1
Ribeiro, AM1
Santos Cruz, J1
Carlton, WW1
Bettendorff, L1
Mastrogiacomo, F1
Wins, P1
Kish, SJ1
Grisar, T1
Ball, MJ1
Gibson, GE1
Zhang, H1
Hayashi, T1
Tanohata, K1
Kunimoto, M1
Inoue, K1
Becker, KW1
Kienecker, EW1
Dick, P1
Ramos Seisdedos, G1
Casas, P1
Beltrán de Heredia, J1
Morgan, KT1
Yonezawa, T1
Iwanami, H1

Reviews

2 reviews available for thiamine and Nerve Degeneration

ArticleYear
Metabolic and structural role of thiamine in nervous tissues.
    Cellular and molecular neurobiology, 2008, Volume: 28, Issue:7

    Topics: Animals; Apoptosis; Brain; Cell Membrane; Hippocampus; Humans; Nerve Degeneration; Neurogenesis; Neu

2008
Interactions of oxidative stress with thiamine homeostasis promote neurodegeneration.
    Neurochemistry international, 2002, Volume: 40, Issue:6

    Topics: Animals; Brain Chemistry; Homeostasis; Humans; Nerve Degeneration; Oxidative Stress; Phosphates; Thi

2002

Other Studies

13 other studies available for thiamine and Nerve Degeneration

ArticleYear
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.
    Cell death & disease, 2015, Jan-15, Volume: 6

    Topics: Amyloid; Amyloid beta-Peptides; Animals; Brain; Caspase 3; Disease Models, Animal; Down-Regulation;

2015
Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase.
    Alcoholism, clinical and experimental research, 2009, Volume: 33, Issue:6

    Topics: Alcoholism; Amprolium; Animals; Cell Death; Cells, Cultured; Central Nervous System Depressants; Coc

2009
Neurodegeneration in thiamine deficient rats-A longitudinal MRI study.
    Brain research, 2010, Jan-13, Volume: 1308

    Topics: Analysis of Variance; Animals; Anisotropy; Brain Mapping; Diffusion Tensor Imaging; Disease Progress

2010
[Aneurin and acetylcholine in nerve degeneration].
    Zeitschrift fur Vitamin-, Hormon- und Fermentforschung, 1951, Volume: 4, Issue:1

    Topics: Acetylcholine; Nerve Degeneration; Peripheral Nerves; Thiamine

1951
Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:5

    Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Antimetabolites; Biomarkers; Brain;

2007
Thiamine deficiency during pregnancy leads to cerebellar neuronal death in rat offspring: role of voltage-dependent K+ channels.
    Brain research, 2007, Feb-23, Volume: 1134, Issue:1

    Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Female; Fetal Nutrition Disorders; Membrane Pot

2007
Studies on the induction of hydrocephalus and spongy degeneration by cuprizone feeding and attempts to antidote the toxicity.
    Life sciences, 1967, Jan-01, Volume: 6, Issue:1

    Topics: Animals; Chelating Agents; Chlorothiazide; Copper; Folic Acid; Hydrocephalus; Male; Mice; Nerve Dege

1967
Low thiamine diphosphate levels in brains of patients with frontal lobe degeneration of the non-Alzheimer's type.
    Journal of neurochemistry, 1997, Volume: 69, Issue:5

    Topics: Adult; Age of Onset; Aged; Analysis of Variance; Autopsy; Cerebral Cortex; Citrate (si)-Synthase; Fe

1997
Marchiafava-Bignami disease with resolving symmetrical putaminal lesion.
    Journal of neurology, 2002, Volume: 249, Issue:2

    Topics: Aged; Alcohol-Induced Disorders, Nervous System; Apraxias; Atrophy; Chronic Disease; Corpus Callosum

2002
A contribution to the scientific assessment of degenerative and regenerative processes of peripheral nerve fibers following axonotmesis under the systemic administration of vitamins B1, B6 and B12--light and electron microscopy findings of the saphenous n
    Neurochirurgia, 1990, Volume: 33, Issue:4

    Topics: Animals; Axons; Dose-Response Relationship, Drug; Hindlimb; Microscopy, Electron; Nerve Degeneration

1990
[Peripheral nerve injury and its muscular repercussions. Experimental study of various therapeutic methods].
    International surgery, 1970, Volume: 53, Issue:6

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Muscles; Nerve Degeneration; Nerve Regen

1970
An ultrastructural study of ovine polio-encephalomalacia.
    The Journal of pathology, 1973, Volume: 110, Issue:2

    Topics: Animals; Blood Proteins; Cerebral Cortex; Cytoplasmic Granules; Edema; Encephalomalacia; Endothelium

1973
An experimental study of thiamine deficiency in nervous tissue, using tissue culture technics.
    Journal of neuropathology and experimental neurology, 1966, Volume: 25, Issue:3

    Topics: Animals; Antimetabolites; Cerebellum; Ganglia, Spinal; In Vitro Techniques; Mice; Myelin Sheath; Ner

1966