Page last updated: 2024-10-20

thiamine and Multiple Organ Failure

thiamine has been researched along with Multiple Organ Failure in 6 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.

Research Excerpts

ExcerptRelevanceReference
"In patients with septic shock, the combination of ascorbic acid, corticosteroids, and thiamine, compared with placebo, did not result in a statistically significant reduction in SOFA score during the first 72 hours after enrollment."2.94Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial. ( Andersen, LW; Becker, LB; Berg, KM; Chase, M; Cocchi, MN; Donnino, MW; Doshi, PB; Gong, J; Grossestreuer, AV; Hershey, M; Hilewitz, A; Hou, PC; Huang, DT; Korotun, M; McCannon, JB; Moskowitz, A; Ngo, L; Otero, RM; Sen, A; Sherwin, RL; Uduman, J, 2020)
"This retrospective study included 132 polytrauma patients admitted to the ICU-CA between January 2013 and December 2014."1.43Modulation of the Redox Expression and Inflammation Response in the Critically Ill Polytrauma Patient with Thoracic Injury. Statistical Correlations between Antioxidant Therapy. ( Bedreag, OH; Cradigati, CA; Dumache, R; Horhat, FG; Luca, L; Papurica, M; Popovici, SE; Rogobete, AF; Sandesc, D; Sarandan, M; Sima, LV; Vernic, C, 2016)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Jazayeri, A1
Nonga, D1
Rao, M1
Moskowitz, A1
Huang, DT1
Hou, PC1
Gong, J1
Doshi, PB1
Grossestreuer, AV1
Andersen, LW1
Ngo, L1
Sherwin, RL1
Berg, KM1
Chase, M1
Cocchi, MN1
McCannon, JB1
Hershey, M1
Hilewitz, A1
Korotun, M1
Becker, LB1
Otero, RM1
Uduman, J1
Sen, A1
Donnino, MW1
Lei, Y1
Zheng, MH1
Huang, W1
Zhang, J1
Lu, Y1
Bedreag, OH1
Rogobete, AF1
Sandesc, D1
Cradigati, CA1
Sarandan, M1
Popovici, SE1
Dumache, R1
Horhat, FG1
Vernic, C1
Sima, LV1
Luca, L1
Papurica, M1
Corcoran, TB1
O'Neill, MP1
Webb, SA1
Ho, KM1
Kountchev, J1
Bijuklic, K1
Bellmann, R1
Joannidis, M1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Thiamine Supplementation on Mortality in Septic Shock. A Controlled Before-and-after Study.[NCT05840718]80 participants (Anticipated)Observational2023-09-30Not yet recruiting
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients, A Retrospective Cohort Study[NCT04710329]78 participants (Actual)Observational2021-01-16Completed
Ascorbic Ccid, Hydrocortisone, and Thiamine in Sepsis and Septic Shock - A Randomized, Double-Blind, Placebo-Controlled Trial[NCT03389555]Phase 2/Phase 3205 participants (Actual)Interventional2018-02-09Completed
Corticosteroids to Reduce Inflammation in Severe Pancreatitis: A Randomized, Controlled Study[NCT05160506]Phase 286 participants (Anticipated)Interventional2022-03-06Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

30-day Mortality

Mortality rate (NCT03389555)
Timeframe: Enrollment until 30-days after enrollment

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids35
Placebo29

Hospital Disposition: Survivors Discharged Home

Home hospital disposition in patients who survive to discharge (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days, whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids34
Placebo35

Hospital Mortality

Hospital mortality rate (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days. Whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids28
Placebo23

ICU Free Days

Number of days that the patient was not in the ICU. Timeframe listed below. (NCT03389555)
Timeframe: From enrollment until 28 days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids22
Placebo21

Intensive Care Unit (ICU) Mortality

ICU mortality rate (NCT03389555)
Timeframe: Enrollment until ICU discharge, death, or 30-days. Whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids23
Placebo20

Number of Participants With Delirium

"Describes if patient has delirium as defined by the Confusion Assessment Method (CAM)-ICU. The CAM-ICU method requires that the patient have 3 features to qualify for delirium:~Acute Onset of Changes or Fluctuations in the Course of Mental Status (AND )~Inattention (AND)~Disorganized thinking (OR) Altered Level of Consciousness" (NCT03389555)
Timeframe: On day 3 (at approximately 72 hours) after the first study drug dose

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids31
Placebo35

Renal Failure

"Development of renal failure as defined by a Kidney Disease Improving Global Outcomes [KDIGO] stage 3 or higher. There are 3 stages in the KDIGO scale with stage 3 being the worst (corresponds to renal failure).~Stage 1- serum creatinine 1.5 to 1.9 times baseline OR an increase in serum creatinine ≥ 0.3 mg/dL OR urine output < 0.5ml/kg/hour for 6-12 hours. Stage 2- serum creatinine 2.0-2.9 times baseline OR urine output <0.5mg/kg/hour for ≥ 12 hours Stage 3- serum creatinine 3.0 times baseline (or serum creatinine of more than or equal to 4.0 mg/dl with an acute increase of at least 0.5 mg/dl) (OR) Urine output less than 0.3 ml/kg/hour for 24 hours or anuria for 12 hours or new renal replacement therapy" (NCT03389555)
Timeframe: Enrollment until 7-days or discharge from the ICU

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids32
Placebo27

Shock Free Days

Days not receiving vasopressor (NCT03389555)
Timeframe: Vasopressor free days over the first 7-days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids5
Placebo4

Ventilator Free Days

Days not receiving invasive mechanical ventilation (NCT03389555)
Timeframe: Ventilator free days over the first 7-days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids6
Placebo6

Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours

Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours. The SOFA score ranges from a minimum of 0 to a maximum of 24, with higher scores meaning worse outcomes. (NCT03389555)
Timeframe: Enrollment to 72-hours

,
InterventionUnits on a scale (Mean)
Enrollment SOFA score72 hour SOFA score
Placebo9.25.1
Vitamin C, Vitamin B1, Corticosteroids9.14.4

Reviews

1 review available for thiamine and Multiple Organ Failure

ArticleYear
Wet beriberi with multiple organ failure remarkably reversed by thiamine administration: A case report and literature review.
    Medicine, 2018, Volume: 97, Issue:9

    Topics: Adult; Alcoholism; Beriberi; Cardiac Output; Humans; Male; Multiple Organ Failure; Prisoners; Thiami

2018

Trials

1 trial available for thiamine and Multiple Organ Failure

ArticleYear
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020

Other Studies

4 other studies available for thiamine and Multiple Organ Failure

ArticleYear
The Key to a Boy's Heart Is Through His Intestine.
    Gastroenterology, 2020, Volume: 158, Issue:5

    Topics: Acute Kidney Injury; Anti-Bacterial Agents; Beriberi; Biopsy; Cardiotonic Agents; Child; Colon, Tran

2020
Modulation of the Redox Expression and Inflammation Response in the Critically Ill Polytrauma Patient with Thoracic Injury. Statistical Correlations between Antioxidant Therapy.
    Clinical laboratory, 2016, Sep-01, Volume: 62, Issue:9

    Topics: Abbreviated Injury Scale; Acetylcysteine; Adult; Aged; Antioxidants; Ascorbic Acid; Critical Illness

2016
Inflammation, vitamin deficiencies and organ failure in critically ill patients.
    Anaesthesia and intensive care, 2009, Volume: 37, Issue:5

    Topics: Adult; Aged; APACHE; Avitaminosis; Biomarkers; C-Reactive Protein; Cohort Studies; Critical Illness;

2009
A patient with severe lactic acidosis and rapidly evolving multiple organ failure: a case of shoshin beri-beri.
    Intensive care medicine, 2005, Volume: 31, Issue:7

    Topics: Acidosis, Lactic; Alcoholism; Beriberi; Humans; Male; Middle Aged; Multiple Organ Failure; Thiamine

2005