thiamine has been researched along with Mitochondrial Diseases in 7 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The diabetic states that associate with these genetic variants are MODY 2, thiamine responsive anaemia syndrome (TRAS) and mitochondrial diabetes." | 8.81 | Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology? ( Maassen, JA, 2002) |
| "Wolfram syndrome, Kearns-Sayre syndrome, thiamine-responsive megaloblastic anemia, and maternally inherited diabetes and deafness are genetic disorders characterized by diabetes, impaired hearing, and vision." | 5.22 | Diabetes Out-of-the-Box: Diabetes Mellitus and Impairment in Hearing and Vision. ( Gruber, N; Pinhas-Hamiel, O, 2022) |
| " The diabetic states that associate with these genetic variants are MODY 2, thiamine responsive anaemia syndrome (TRAS) and mitochondrial diabetes." | 4.81 | Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology? ( Maassen, JA, 2002) |
| "We reviewed the medical records of all patients with confirmed mitochondrial diseases treated with any or all of thiamin, riboflavin, coenzyme Q, vitamin C (approximately 10 mg/kg per day) and a high-fat diet (50-60% of caloric intake) between 1997 and 2003." | 3.72 | Effect of high-dose vitamins, coenzyme Q and high-fat diet in paediatric patients with mitochondrial diseases. ( Boneh, A; Panetta, J; Smith, LJ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Gruber, N | 1 |
| Pinhas-Hamiel, O | 1 |
| Tinsa, F | 1 |
| Hechmi, M | 1 |
| Hadj, IB | 1 |
| Khalsi, F | 1 |
| Chargui, M | 1 |
| Kefi, R | 1 |
| Azouz, H | 1 |
| Boussetta, K | 1 |
| Abdelhak, S | 1 |
| Jungtrakoon, P | 1 |
| Shirakawa, J | 1 |
| Buranasupkajorn, P | 1 |
| Gupta, MK | 1 |
| De Jesus, DF | 1 |
| Pezzolesi, MG | 1 |
| Panya, A | 1 |
| Hastings, T | 1 |
| Chanprasert, C | 1 |
| Mendonca, C | 1 |
| Kulkarni, RN | 1 |
| Doria, A | 1 |
| Maassen, JA | 1 |
| Panetta, J | 1 |
| Smith, LJ | 1 |
| Boneh, A | 1 |
| Suzuki, S | 1 |
| Kuroda, Y | 1 |
| Naito, E | 1 |
| Touda, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Label Pilot Study Using Hydroxytyrosol (HT) as a Dietary Supplement in Patients With Mitochondrial Diseases (MDs)[NCT04543968] | 12 participants (Anticipated) | Interventional | 2022-07-05 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for thiamine and Mitochondrial Diseases
| Article | Year |
|---|---|
Diabetes Out-of-the-Box: Diabetes Mellitus and Impairment in Hearing and Vision.
Topics: Anemia, Megaloblastic; Deafness; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hearing; Hearing Loss | 2022 |
Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology?
Topics: Anemia, Megaloblastic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Mitochondrial Diseases; | 2002 |
[Role of mitochondrial dysfunction in pathogenesis of diabetic microangiopathy].
Topics: Antioxidants; Coenzymes; Diabetic Angiopathies; DNA Damage; DNA, Mitochondrial; Drug Design; Electro | 2005 |
[Drug therapy for mitochondrial diseases].
Topics: Carnitine; Coenzymes; Cytochrome c Group; Cytochromes c; Dichloroacetic Acid; Drug Combinations; Dru | 2002 |
3 other studies available for thiamine and Mitochondrial Diseases
| Article | Year |
|---|---|
Thiamine responsive megaloblastic anemia mimicking mitochondrial disorders.
Topics: Anemia, Megaloblastic; Child, Preschool; Diagnosis, Differential; Humans; Male; Mitochondrial Diseas | 2019 |
Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes.
Topics: Anemia, Megaloblastic; Cell Cycle Checkpoints; Diabetes Mellitus; Humans; Insulin; Membrane Transpor | 2019 |
Effect of high-dose vitamins, coenzyme Q and high-fat diet in paediatric patients with mitochondrial diseases.
Topics: Adolescent; Ascorbic Acid; Child; Child, Preschool; Dietary Fats; DNA, Mitochondrial; Female; Humans | 2004 |