Compounds > thiamine
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thiamine and Intellectual Disability

thiamine has been researched along with Intellectual Disability in 30 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)

Research Excerpts

ExcerptRelevanceReference
"Although thiamine deficiency (TD) and Wernicke encephalopathy (WE) are not rare in cancer patients, the cases reported to date developed TD and/or WE after treatment had started."7.91Subclinical thiamine deficiency identified by preoperative evaluation in an ovarian cancer patient: Diagnosis and the need for preoperative thiamine measurement. ( Akechi, T; Fujiwara, K; Hasegawa, K; Ishida, M; Nishikawa, T; Onishi, H; Shintani, D; Uchida, N, 2019)
" This infant was found to have lactic acidosis, low cerebrospinal fluid glucose, hyperalaninemia, and increased levels of urine lactate, pyruvate and alanine."7.65Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid. ( Komiya, K; Maesaka, H; Misugi, K; Tada, K, 1976)
"Although thiamine deficiency (TD) and Wernicke encephalopathy (WE) are not rare in cancer patients, the cases reported to date developed TD and/or WE after treatment had started."3.91Subclinical thiamine deficiency identified by preoperative evaluation in an ovarian cancer patient: Diagnosis and the need for preoperative thiamine measurement. ( Akechi, T; Fujiwara, K; Hasegawa, K; Ishida, M; Nishikawa, T; Onishi, H; Shintani, D; Uchida, N, 2019)
" This infant was found to have lactic acidosis, low cerebrospinal fluid glucose, hyperalaninemia, and increased levels of urine lactate, pyruvate and alanine."3.65Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid. ( Komiya, K; Maesaka, H; Misugi, K; Tada, K, 1976)
"Thirdly, the peculiar pathology of trisomy 21 allows to find also a cholinergic disturbance and a disturbance close to the 10 formyl-tetrahydrololate entry of the folate cycle."1.26[Biochemical investigations and trisomy 21 (author's transl)]. ( Lejeune, J, 1979)
"Treatment with thiamine derivatives may have a beneficial effect on the clinical course."1.25[Subacute necrotizing encephalomyelopathy (Leigh's disease) (author's transl)]. ( Förster, C; Murken, JD, 1975)
"Thiamine treatment was followed by a decrease of serum alanine and blood pyruvate and lactate, but there was no clinical improvement during a period of 17 months."1.25Subacute necrotizing encephalomyelopathy. Clinical, ultrastructural, biochemical and therapeutic studies in an infant. ( Bassewitz, DB; Dominick, HC; Gröbe, H; Pfeiffer, RA, 1975)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199028 (93.33)18.7374
1990's1 (3.33)18.2507
2000's0 (0.00)29.6817
2010's1 (3.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Onishi, H1
Ishida, M1
Uchida, N1
Shintani, D1
Nishikawa, T1
Hasegawa, K1
Fujiwara, K1
Akechi, T1
MOURIQUAND, G1
EDEL, V1
CAMPIONI, T1
DONELLI, A1
ISRAELS, S1
HAWORTH, JC1
GOURLEY, B1
FORD, JD1
LOUTTIT, RT1
RUDOLF, Gde M2
Takusa, Y1
Hanaoka, S1
Lejeune, J1
Maesaka, H1
Komiya, K1
Misugi, K1
Tada, K1
Förster, C1
Murken, JD1
Gröbe, H1
Bassewitz, DB1
Dominick, HC1
Pfeiffer, RA1
Murphy, JV3
Perper, JA1
Schmitz, KW1
Grimm, U1
Schulz, M1
Smetan, M1
Knapp, A1
Schmitz, W1
Brunette, MG1
Delvin, E1
Hazel, B1
Scriver, CR1
Pincus, JH4
Grover, WD1
Auerbach, VH1
Patel, MS1
Cooper, JR3
Rabe, EF1
Lonsdale, D1
Dunn, HG2
de Groot, CJ1
Hommes, FA2
Berger, R1
Luit-de-Haan, G1
Mortier, W1
Michaelis, E1
Gordon, N1
Marsden, HB1
Lewis, DM1
Leiber, B1
Hövels, O1
Piros, K1
Turner, V1
Dolman, CL1
Itokawa, Y1
Gumbinas, M1
Vincze, RM1

Other Studies

30 other studies available for thiamine and Intellectual Disability

ArticleYear
Subclinical thiamine deficiency identified by preoperative evaluation in an ovarian cancer patient: Diagnosis and the need for preoperative thiamine measurement.
    Palliative & supportive care, 2019, Volume: 17, Issue:5

    Topics: Adult; Female; Humans; Intellectual Disability; Ovarian Neoplasms; Preoperative Care; Thiamine; Thia

2019
[Hormone-vitamin medication; association of thyroxin and thiamin in mental and physical retardation].
    Pediatrie, 1953, Volume: 8, Issue:3

    Topics: Diet, Reducing; Humans; Intellectual Disability; Thiamine; Thyroxine; Vitamins

1953
[Therapeutic study of glutamic acid combined with a new organic phosphorus compound, ditetraethylammonium phosphate].
    Rassegna di studi psichiatrici, 1954, Volume: 43, Issue:4

    Topics: Diet, Reducing; Glutamates; Glutamic Acid; Intellectual Disability; Neurotic Disorders; Organophosph

1954
[Clinical and psychological data on therapeutics of oligophrenia in children; treatment with a preparation of glutamic acid, ditetraethylammonium phosphate and vitamin B1].
    Gazzetta medica italiana, 1957, Volume: 116, Issue:3

    Topics: Coal Tar; Diet, Reducing; Glutamates; Glutamic Acid; Intellectual Disability; Mental Disorders; Phos

1957
CHRONIC ACIDOSIS DUE TO AN ERROR IN LACTATE AND PYRUVATE METABOLISM. REPORT OF TWO CASES.
    Pediatrics, 1964, Volume: 34

    Topics: Acetoacetates; Acidosis; Blood; Blood Gas Analysis; Carbohydrate Metabolism; Carbohydrate Metabolism

1964
CHEMICAL FACILITATION OF INTELLIGENCE AMONG THE MENTALLY RETARDED.
    American journal of mental deficiency, 1965, Volume: 69

    Topics: Autonomic Agents; Central Nervous System Stimulants; Chlorpromazine; Chorionic Gonadotropin; Drug Th

1965
Changes continuing after the termination of treatment of mental defectives with aneurin.
    The Journal of mental science, 1950, Volume: 96, Issue:404

    Topics: Intellectual Disability; Thiamine

1950
The treatment of mental defectives with thiamine.
    The Journal of mental science, 1949, Volume: 95, Issue:401

    Topics: Intellectual Disability; Thiamine

1949
TREATMENT of mental defectives with thiamine.
    Nutrition reviews, 1950, Volume: 8, Issue:8

    Topics: Humans; Intellectual Disability; Thiamine

1950
[Magnetic resonance imaging in thiamine responsive pyruvate dehydrogenase complex deficiency].
    No to shinkei = Brain and nerve, 1996, Volume: 48, Issue:12

    Topics: Acidosis, Lactic; Brain; Child, Preschool; Female; Humans; Intellectual Disability; Magnetic Resonan

1996
[Biochemical investigations and trisomy 21 (author's transl)].
    Annales de genetique, 1979, Volume: 22, Issue:2

    Topics: Down Syndrome; Folic Acid; Glyoxylates; Humans; Hydrogen Peroxide; Intellectual Disability; Oxalates

1979
Hyperalaninemia hyperpyruvicemia and lactic acidosis due to pyruvate carboxylase deficiency of the liver; treatment with thiamine and lipoic acid.
    European journal of pediatrics, 1976, May-04, Volume: 122, Issue:2

    Topics: Acidosis; Alanine; Female; Glucose; Humans; Infant; Intellectual Disability; Lactates; Liver; Metabo

1976
[Subacute necrotizing encephalomyelopathy (Leigh's disease) (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1975, Volume: 123, Issue:2

    Topics: Age Factors; Ataxia; Athetosis; Autopsy; Brain Stem; Child; Child, Preschool; Chorea; Encephalomalac

1975
Subacute necrotizing encephalomyelopathy. Clinical, ultrastructural, biochemical and therapeutic studies in an infant.
    Acta paediatrica Scandinavica, 1975, Volume: 64, Issue:5

    Topics: Alanine; Brain Stem; Encephalomalacia; Female; Glycogen; Humans; Infant; Intellectual Disability; La

1975
Crib-death syndrome.
    Lancet (London, England), 1973, Mar-17, Volume: 1, Issue:7803

    Topics: Brain Chemistry; Brain Stem; Death, Sudden; Encephalomalacia; Humans; Infant; Infant, Newborn; Intel

1973
[Studies on tryptophan metabolism in oligophrenic children. 2. Vitamin-dependent enzyme patterns (B1, B2, B6) and excretion of the tryptophan metabolites kynurenin, xanthurenic acid, trigonellinamide, and N-methylpyridone].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1974, Volume: 26, Issue:6

    Topics: Child; Female; Humans; Hydrolases; Intellectual Disability; Kynurenine; Liver; Male; NADP; Pyridoxin

1974
Thiamine-responsive lactice acidosis in a patient with deficient low-KM pyruvate carboxylase activity in liver.
    Pediatrics, 1972, Volume: 50, Issue:5

    Topics: Acidosis; Adrenocorticotropic Hormone; Alanine; Amino Acids; Diet Therapy; Female; Gluconeogenesis;

1972
Efficacy of recommended therapeutic regimens in Leigh's disease.
    Developmental medicine and child neurology, 1974, Volume: 16, Issue:3

    Topics: Brain Stem; Drug Therapy, Combination; Encephalomalacia; Glutamine; Humans; Intellectual Disability;

1974
Subacute necrotizing encephalomyelopathy (Leigh's disease): a consideration of clinical features and etiology.
    Developmental medicine and child neurology, 1972, Volume: 14, Issue:1

    Topics: Age Factors; Brain Stem; Carbon Dioxide; Chronic Disease; Encephalomalacia; Humans; Infant; Infant,

1972
Biochemical studies and therapy in subacute necrotizing encephalomyelopathy (Leigh's syndrome).
    The Journal of pediatrics, 1972, Volume: 81, Issue:1

    Topics: Biotin; Brain; Brain Stem; Carboxy-Lyases; Encephalomalacia; Humans; Infant; Intellectual Disability

1972
Thiamine derivatives in subacute necrotizing encephalomyelopathy. A preliminary report.
    Pediatrics, 1973, Volume: 51, Issue:4

    Topics: Autopsy; Brain Stem; Child; Encephalomalacia; Humans; Intellectual Disability; Medical Records; Psyc

1973
Further speculation on the pathogenesis of Leigh's encephalomyelopathy.
    The Journal of pediatrics, 1973, Volume: 82, Issue:3

    Topics: Aspartic Acid; Brain Stem; Citric Acid Cycle; Encephalomalacia; Humans; Intellectual Disability; Lig

1973
The effect of thiamine treatment on the activity of pyruvate dehydrogenase: relation of the treatment of Leigh's encephalomyelopathy.
    Pediatric research, 1973, Volume: 7, Issue:7

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Brain Stem; Encephalomalacia; Female; Humans

1973
[Subacute necrotizing encephalomyelopathy in identical twins. Pathogenetic and therapeutic aspects].
    Monatsschrift fur Kinderheilkunde, 1973, Volume: 121, Issue:7

    Topics: Brain Stem; Child, Preschool; Diseases in Twins; Encephalomalacia; Female; Humans; Infant; Intellect

1973
Subacute necrotising encephalomyelopathy in three siblings.
    Developmental medicine and child neurology, 1974, Volume: 16, Issue:1

    Topics: Age Factors; Alanine; Brain; Brain Stem; Child, Preschool; Encephalomalacia; Female; Gluconeogenesis

1974
[Leigh's syndrome].
    Monatsschrift fur Kinderheilkunde, 1974, Volume: 122, Issue:1

    Topics: Brain Stem; Encephalomalacia; Female; Humans; Infant; Intellectual Disability; Male; Psychomotor Dis

1974
Specificity of the urine inhibitor test for Leigh's disease.
    Neurology, 1974, Volume: 24, Issue:9

    Topics: Brain Stem; Diagnosis, Differential; Diagnostic Errors; Encephalomalacia; False Negative Reactions;

1974
Necrotizing encephalomyelopathy. Report of a case with manifestations resembling Behr's syndrome.
    European neurology, 1972, Volume: 7, Issue:1

    Topics: Autopsy; Brain; Brain Stem; Cerebellar Ataxia; Child; Diagnosis, Differential; Encephalomalacia; Hum

1972
Subacute necrotizing encephalomyelopathy. Effects of thiamine and thiamine propyl disulfide.
    Archives of neurology, 1971, Volume: 24, Issue:6

    Topics: Body Weight; Brain Stem; Encephalomalacia; Formates; Humans; Infant; Intellectual Disability; Male;

1971
[First results with Calbion in the psychosomatic treatment of exceptional children].
    Hospital (Rio de Janeiro, Brazil), 1967, Volume: 72, Issue:3

    Topics: Adolescent; Aminobutyrates; Child; Child, Preschool; Female; Humans; Intellectual Disability; Male;

1967