Page last updated: 2024-10-20

thiamine and Idiopathic Parkinson Disease

thiamine has been researched along with Idiopathic Parkinson Disease in 9 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Research Excerpts

ExcerptRelevanceReference
"To investigate the potential clinical, restorative, and neuroprotective effects of long-term treatment with thiamine in Parkinson disease (PD)."7.81Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study. ( Cardelli, LE; Colangeli, M; Costantini, A; Fancellu, R; Grossi, E; Jenner, C; Mondonico, S; Pala, MI; Proietti, S, 2015)
"To investigate the potential clinical, restorative, and neuroprotective effects of long-term treatment with thiamine in Parkinson disease (PD)."3.81Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study. ( Cardelli, LE; Colangeli, M; Costantini, A; Fancellu, R; Grossi, E; Jenner, C; Mondonico, S; Pala, MI; Proietti, S, 2015)
"Thiamine has also been implicated in PD through its effects on L-type voltage-sensitive calcium channels (L-VSCC), matrix metalloproteinases (MMPs), prostaglandins (PGs), cyclooxygenase-2 (COX-2), reactive oxygen species (ROS), and nitric oxide synthase (NOS)."2.48Thiamine and Parkinson's disease. ( Lu'o'ng, Kv; Nguyên, LT, 2012)
"We performed the Unified Parkinson's Disease Rating Scale (UPDRS) and started a parenteral therapy with high doses of thiamine."1.39High-dose thiamine as initial treatment for Parkinson's disease. ( Colangeli, M; Compagnoni, L; Costantini, A; Pala, MI, 2013)
"Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC), pyruvate-dehydrogenase complex, and transketolase."1.30Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease. ( Barcenilla, B; Berbel, A; de Bustos, F; Fernández-Vivancos, E; Gómez-Escalonilla, C; Hernánz, A; Jiménez-Jiménez, FJ; Molina, JA; Villanueva, C; Zurdo, M, 1999)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's1 (11.11)29.6817
2010's5 (55.56)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Håglin, L1
Domellöf, M1
Bäckman, L1
Forsgren, L1
Luong, KV1
Nguyễn, LT2
Costantini, A2
Pala, MI2
Compagnoni, L1
Colangeli, M2
Grossi, E1
Mondonico, S1
Cardelli, LE1
Jenner, C1
Proietti, S1
Fancellu, R1
Santos-García, D1
Macías, M1
Llaneza, M1
Grande, M1
de la Fuente-Fernández, R1
Lu'o'ng, Kv1
Balk, E1
Chung, M1
Raman, G1
Tatsioni, A1
Chew, P1
Ip, S1
DeVine, D1
Lau, J1
Gold, M1
Hauser, RA1
Chen, MF1
Jiménez-Jiménez, FJ1
Molina, JA1
Hernánz, A1
Fernández-Vivancos, E1
de Bustos, F1
Barcenilla, B1
Gómez-Escalonilla, C1
Zurdo, M1
Berbel, A1
Villanueva, C1

Reviews

3 reviews available for thiamine and Idiopathic Parkinson Disease

ArticleYear
The beneficial role of thiamine in Parkinson disease.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:7

    Topics: Animals; Humans; Parkinson Disease; Signal Transduction; Thiamine; Vitamins

2013
Thiamine and Parkinson's disease.
    Journal of the neurological sciences, 2012, May-15, Volume: 316, Issue:1-2

    Topics: Animals; Biomarkers; Cyclooxygenase 2; Humans; Oxidative Stress; Parkinson Disease; Reactive Oxygen

2012
B vitamins and berries and age-related neurodegenerative disorders.
    Evidence report/technology assessment, 2006, Issue:134

    Topics: Aging; Alzheimer Disease; Animals; Blueberry Plants; Cognition; Disease Models, Animal; Folic Acid;

2006

Other Studies

6 other studies available for thiamine and Idiopathic Parkinson Disease

ArticleYear
Low plasma thiamine and phosphate in male patients with Parkinson's disease is associated with mild cognitive impairment.
    Clinical nutrition ESPEN, 2020, Volume: 37

    Topics: Case-Control Studies; Cognitive Dysfunction; Female; Humans; Male; Parkinson Disease; Phosphates; Th

2020
High-dose thiamine as initial treatment for Parkinson's disease.
    BMJ case reports, 2013, Aug-28, Volume: 2013

    Topics: Aged; Female; Humans; Male; Parkinson Disease; Thiamine; Treatment Outcome; Vitamin B Complex

2013
Long-Term Treatment with High-Dose Thiamine in Parkinson Disease: An Open-Label Pilot Study.
    Journal of alternative and complementary medicine (New York, N.Y.), 2015, Volume: 21, Issue:12

    Topics: Aged; Antiparkinson Agents; Disease Management; Dose-Response Relationship, Drug; Humans; Male; Midd

2015
Serum vitamin B(12) and folate levels in Parkinson's disease patients treated with duodenal levodopa infusion.
    Movement disorders : official journal of the Movement Disorder Society, 2011, Feb-15, Volume: 26, Issue:3

    Topics: Aged; Antiparkinson Agents; Female; Folic Acid; Humans; Infusions, Parenteral; Levodopa; Male; Middl

2011
Plasma thiamine deficiency associated with Alzheimer's disease but not Parkinson's disease.
    Metabolic brain disease, 1998, Volume: 13, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Female; Humans; Male; Middle Aged; Parkinson Dise

1998
Cerebrospinal fluid levels of thiamine in patients with Parkinson's disease.
    Neuroscience letters, 1999, Aug-13, Volume: 271, Issue:1

    Topics: Antiparkinson Agents; Dopamine Agonists; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Dise

1999