Page last updated: 2024-10-20

thiamine and Hyperglycemia

thiamine has been researched along with Hyperglycemia in 30 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
"The present study investigated the effect of thiamine disulfide (TD) on the pancreas in terms of hyperglycemia improvement and insulin sensitivity increase in diabetic male rats."8.12The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide. ( Meamar, R; Rad, MG; Sharifi, M; Soltani, N, 2022)
"Thiamine is a coenzyme important in intracellular glucose metabolism."6.72Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. ( Abularrage, CJ; Arora, S; Kellicut, D; Lidor, A; Nylen, E; Sidawy, AN; Weiswasser, JM, 2006)
"Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient."6.47Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. ( Cummings, MH; Laight, D; Page, GL, 2011)
"Insulin resistance is the first step in glucose intolerance and the development of type 2 diabetes mellitus, thus effective prevention strategies should also include dietary interventions to enhance insulin sensitivity."5.38Effects of combined dietary chromium(III) propionate complex and thiamine supplementation on insulin sensitivity, blood biochemical indices, and mineral levels in high-fructose-fed rats. ( Bogdański, P; Krejpcio, Z; Król, E; Michalak, S; Wójciak, RW, 2012)
"The present study investigated the effect of thiamine disulfide (TD) on the pancreas in terms of hyperglycemia improvement and insulin sensitivity increase in diabetic male rats."4.12The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide. ( Meamar, R; Rad, MG; Sharifi, M; Soltani, N, 2022)
"Low thiamine levels are associated with elevated blood glucose and hypertension in Saudi adults."3.79Thiamine and its phosphate esters in relation to cardiometabolic risk factors in Saudi Arabs. ( Abd-Alrahman, SH; Al-Attas, OS; Al-Daghri, NM; Alkharfy, KM; Alokail, MS; Sabico, S, 2013)
"To determine the effect of high dose thiamine on dyslipidemia in diabetic rats."3.75Effect of thiamine on lipid profile in diabetic rats. ( Ahmad, I; Malik, MM; Naveed, AK; Qamar, T; Raheem, A, 2009)
" We aimed at investigating whether pulsed exposure to different glucose concentrations influences apoptosis in human retinal pericytes (HRP) versus bovine retinal pericytes (BRP), with consequences on the onset of diabetic retinopathy, and the possible protective role of thiamine."3.75Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine. ( Beltramo, E; Berrone, E; Porta, M; Tarallo, S, 2009)
"In patients with septic shock, the combination of ascorbic acid, corticosteroids, and thiamine, compared with placebo, did not result in a statistically significant reduction in SOFA score during the first 72 hours after enrollment."2.94Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial. ( Andersen, LW; Becker, LB; Berg, KM; Chase, M; Cocchi, MN; Donnino, MW; Doshi, PB; Gong, J; Grossestreuer, AV; Hershey, M; Hilewitz, A; Hou, PC; Huang, DT; Korotun, M; McCannon, JB; Moskowitz, A; Ngo, L; Otero, RM; Sen, A; Sherwin, RL; Uduman, J, 2020)
"Male participants with and without type 1 diabetes were studied in the General Clinical Research Centre of the Albert Einstein College of Medicine."2.73Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. ( Brownlee, M; Du, X; Edelstein, D, 2008)
"Thiamine is a coenzyme important in intracellular glucose metabolism."2.72Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. ( Abularrage, CJ; Arora, S; Kellicut, D; Lidor, A; Nylen, E; Sidawy, AN; Weiswasser, JM, 2006)
"Thirteen people with type 2 diabetes were given a heat-processed test meal with a high AGE content (HAGE; 15."2.72Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. ( Gawlowski, T; Götting, C; Horstmann, T; Kleesiek, K; Koschinsky, T; Mueller-Roesel, M; Negrean, M; Stirban, A; Stratmann, B; Tschoepe, D; Uribarri, J; Vlassara, H, 2006)
"Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient."2.47Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. ( Cummings, MH; Laight, D; Page, GL, 2011)
"Insulin resistance is the first step in glucose intolerance and the development of type 2 diabetes mellitus, thus effective prevention strategies should also include dietary interventions to enhance insulin sensitivity."1.38Effects of combined dietary chromium(III) propionate complex and thiamine supplementation on insulin sensitivity, blood biochemical indices, and mineral levels in high-fructose-fed rats. ( Bogdański, P; Krejpcio, Z; Król, E; Michalak, S; Wójciak, RW, 2012)
"Hyperglycemia is a causal factor in the development of the vascular complications of diabetes."1.33Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. ( Ape, AU; Beltramo, E; Berrone, E; Porta, M; Solimine, C, 2006)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19903 (10.00)18.7374
1990's0 (0.00)18.2507
2000's12 (40.00)29.6817
2010's9 (30.00)24.3611
2020's6 (20.00)2.80

Authors

AuthorsStudies
Yako, H1
Niimi, N1
Kato, A1
Takaku, S1
Tatsumi, Y1
Nishito, Y1
Kato, K2
Sango, K1
Rad, MG1
Sharifi, M1
Meamar, R1
Soltani, N1
Dhanani, LY1
Totton, RR1
Jara-Quijada, E1
Pérez-Won, M1
Tabilo-Munizaga, G1
Lemus-Mondaca, R1
González-Cavieres, L1
Palma-Acevedo, A1
Herrera-Lavados, C1
Milovanovic, S1
Grzegorczyk, A1
Świątek, Ł1
Grzęda, A1
Dębczak, A1
Tyskiewicz, K1
Konkol, M1
Li, Y3
Chang, P1
Sankaran, S1
Jang, H1
Nie, Y1
Zeng, A1
Hussain, S1
Wu, JY1
Chen, X2
Shi, L2
Senapati, A1
Chetri, BK1
Mitra, S1
Shelke, RG1
Rangan, L1
Chauhan, AS1
Tiwari, M1
Indoliya, Y1
Mishra, SK1
Lavania, UC1
Chauhan, PS1
Chakrabarty, D1
Tripathi, RD1
Akaputra, R1
Hatta, M1
Massi, MN1
Djaharuddin, I1
Bukhari, A1
Aminuddin, A1
Santoso, A1
Natzir, R1
Bahar, B1
Fachri, M1
Farsida, F1
Fathimah, A1
Ubaidah, FM1
Sridiana, E1
Dwiyanti, R1
Syukri, A1
Junita, AR1
Febrianti, A1
Primaguna, MR1
Azhar, A1
Rajaure, YS1
Thapa, B1
Budhathoki, L1
Rana, SR1
Khadka, M1
Batchu, UR1
Surapaneni, JR1
Cheemalamarri, C1
Mandava, K1
Puvvada, N1
Shetty, PR1
Mv, S1
Ranjbarian, P1
Goudarzi, F1
Akya, A1
Heidarinia, H1
Farasat, A1
Rostamian, M1
Suri, K1
Rajput, N1
Sharma, P1
Omble, AD1
Kulkarni, K1
Gahlay, GK1
Fernandez Garcia, E1
Paudel, U1
Noji, MC1
Bowman, CE1
Rustgi, AK1
Pitarresi, JR1
Wellen, KE1
Arany, Z1
Weissenrieder, JS1
Foskett, JK1
Lee, MS1
Han, HJ1
Choi, TI1
Lee, KH1
Baasankhuu, A1
Kim, HT1
Kim, CH1
Redd, PS1
Payero, L1
Gilbert, DM1
Page, CA1
King, R1
McAssey, EV1
Bodie, D1
Diaz, S1
Hancock, CN1
Lee, HS1
Jung, S1
Lee, SW1
Kim, YT1
Lee, J1
Ren, T1
Yu, Z1
Yu, H1
Deng, K1
Wang, Z1
Li, X1
Wang, H1
Wang, L2
Xu, Y1
Lascano, J1
Riley, L1
Khodayari, N1
Brantly, M1
Gupta, R1
Pradhan, J1
Haldar, A1
Murapaka, C1
Chandra Mondal, P1
Gao, R1
Dai, TY1
Meng, Z1
Sun, XF1
Liu, DX1
Shi, MM1
Li, HR1
Kang, X1
Bi, B1
Zhang, YT1
Xu, TW1
Yan, JM1
Jiang, Q1
Helmchen, G1
Guo, H1
Xiang, W1
Fang, Y1
Li, J4
Lin, Y1
An, X1
Jiang, D1
Cao, Q1
Xu, F1
Shiigi, H1
Wang, W1
Chen, Z1
Akosman, I1
Kumar, N1
Mortenson, R1
Lans, A1
De La Garza Ramos, R1
Eleswarapu, A1
Yassari, R1
Fourman, MS1
Jana, S1
Evans, EGB1
Jang, HS1
Zhang, S2
Zhang, H1
Rajca, A1
Gordon, SE1
Zagotta, WN1
Stoll, S1
Mehl, RA1
Miller, S1
Lee, DA1
Muhimpundu, S1
Maxwell, CA1
Liu, Z1
Shen, F1
Tong, Q1
Tang, M1
Peng, M1
Jiao, Z1
Jiang, Y1
Ao, L1
Fu, W1
Lv, X1
Jiang, G1
Hou, L1
Tu, WC1
McManamen, AM1
Su, X1
Jeacopello, I1
Takezawa, MG1
Hieber, DL1
Hassan, GW1
Lee, UN1
Anana, EV1
Locknane, MP1
Stephenson, MW1
Shinkawa, VAM1
Wald, ER1
DeMuri, GP1
Adams, KN1
Berthier, E1
Thongpang, S1
Theberge, AB1
Jiang, L1
Li, Z1
Dong, Q1
Rong, X1
Dong, G1
Huang, J1
Liang, Y1
Sun, S1
Zhang, R1
Miao, Z1
Senju, C1
Nakazawa, Y1
Oso, T1
Shimada, M1
Matsuse, M1
Tsujimoto, M1
Masaki, T1
Miyazaki, Y1
Fukushima, S1
Tateishi, S1
Utani, A1
Murota, H1
Tanaka, K1
Mitsutake, N1
Moriwaki, S1
Nishigori, C1
Ogi, T1
Liu, C1
Zhang, X2
Wang, B1
Luo, Z1
Qian, D1
Liu, J1
Waterhouse, GIN1
Barbosa, M1
Marques-Sá, J1
Carvalho, C1
Fernandes, V1
Grilli, D1
Smetana, V1
Ahmed, SJ1
Shtender, V1
Pani, M1
Manfrinetti, P1
Mudring, AV1
Kuang, Y1
Yang, D1
Gai, S1
He, F1
An, B1
Yang, P1
Notini, L1
Schulz, K1
Kubeneck, LJ1
Grigg, ARC1
Rothwell, KA1
Fantappiè, G1
ThomasArrigo, LK1
Kretzschmar, R1
Siswanto, FM1
Okukawa, K1
Tamura, A1
Oguro, A1
Imaoka, S1
Kim, CG1
Jung, M1
Kim, HS1
Lee, CK1
Jeung, HC1
Koo, DH1
Bae, WK1
Zang, DY1
Kim, BJ1
Kim, H1
Yun, UJ1
Che, J1
Park, S1
Kim, TS1
Kwon, WS1
Park, J1
Cho, SW1
Nam, CM1
Chung, HC1
Rha, SY1
Colombo, N1
Van Gorp, T1
Matulonis, UA1
Oaknin, A1
Grisham, RN1
Fleming, GF1
Olawaiye, AB1
Nguyen, DD1
Greenstein, AE1
Custodio, JM1
Pashova, HI1
Tudor, IC1
Lorusso, D1
Zhou, F1
Jiang, Z1
Liang, H1
Ru, S1
Bettiol, AA1
Gao, W1
Lipsyc-Sharf, M1
Jain, E1
Collins, LC1
Rosenberg, SM1
Ruddy, KJ1
Tamimi, RM1
Schapira, L1
Come, SE1
Peppercorn, JM1
Borges, VF1
Warner, E1
Snow, C1
Krop, IE1
Kim, D1
Weiss, J1
Zanudo, JGT1
Partridge, AH1
Wagle, N1
Waks, AG1
Moskowitz, A2
Berg, KM2
Grossestreuer, AV2
Balaji, L1
Liu, X1
Cocchi, MN2
Chase, M2
Gong, MN1
Gong, J2
Parikh, SM1
Ngo, L2
Berlin, N1
Donnino, MW2
Zhou, Y1
Chen, Q1
Zhong, S1
Liu, H1
Koh, K1
Chen, H1
He, J1
Chen, J1
Liu, S1
Lin, L1
Zhang, Y1
Xiao, S1
Cao, S1
Yan, B2
Deng, J1
Gu, J1
Tao, Y1
Huang, C1
Lai, C1
Yong, Q1
Shen, Y1
Gong, Z1
Cao, J1
Mao, W1
Yao, Y1
Zhao, J1
Li, Q1
Liu, K1
Liu, B1
Feng, S1
Chandran, V1
Kunjan, C1
Veerapandian, V1
Kannan, R1
Zhang, T1
von Gunten, U1
Caruso, FR1
Goulart, CDL1
Jr, JCB1
de Oliveira, CR1
Mendes, RG1
Arena, R1
Borghi-Silva, A1
Carrasco-Nuñes, N1
Romano, M1
Cabeza, M1
Jiang, B1
Chen, D1
Zhao, C1
Ma, Y1
Yang, W1
Shen, X1
Satheeshkumar, K1
Saravanakumar, P1
Kalavathi, A1
Vennila, KN1
Elango, KP1
Mues Genannt Koers, L1
Prevost, D1
Paulssen, E1
Hoehr, C1
Ulhassan, Z1
Yang, S1
He, D1
Khan, AR1
Salam, A1
Azhar, W1
Muhammad, S1
Ali, S1
Hamid, Y1
Khan, I1
Sheteiwy, MS1
Zhou, W1
Wang, X1
Xie, Q1
Wang, Y1
Lü, H1
Fu, M1
Wang, D1
Qin, YY1
Ye, Y1
Lin, FQ1
Biró, A1
Markovics, A1
Fazekas, MÉ1
Fidler, G1
Szalóki, G1
Paholcsek, M1
Lukács, J1
Stündl, L1
Remenyik, J1
Huang, DT1
Hou, PC1
Doshi, PB1
Andersen, LW1
Sherwin, RL1
McCannon, JB1
Hershey, M1
Hilewitz, A1
Korotun, M1
Becker, LB1
Otero, RM1
Uduman, J1
Sen, A1
Chalásová, K1
Pácal, L1
Pleskačová, A1
Knopfová, L1
Řehořová, J1
Tomandlová, M1
Tomandl, J1
Kaňková, K1
Souki, FG1
Ghaffaripour, S1
Martinez-Lu, K1
Mahmoudi, H1
Stirban, A2
Pop, A1
Fischer, A1
Heckermann, S1
Tschoepe, D2
Al-Daghri, NM1
Al-Attas, OS1
Alkharfy, KM1
Alokail, MS1
Abd-Alrahman, SH1
Sabico, S1
Du, X2
Edelstein, D2
Brownlee, M2
Naveed, AK1
Qamar, T1
Ahmad, I1
Raheem, A1
Malik, MM1
Wang, C1
Zhu, K1
Dong, YM1
Sun, CH1
Beltramo, E3
Berrone, E3
Tarallo, S2
Porta, M3
Nizheradze, K1
Balakumar, P1
Rohilla, A1
Krishan, P1
Solairaj, P1
Thangathirupathi, A1
Page, GL1
Laight, D1
Cummings, MH1
Król, E1
Krejpcio, Z1
Michalak, S1
Wójciak, RW1
Bogdański, P1
Engelen, L1
Stehouwer, CD1
Schalkwijk, CG1
Teodoro, JS1
Gomes, AP1
Varela, AT1
Duarte, FV1
Rolo, AP1
Palmeira, CM1
Hammes, HP1
Taguchi, T1
Matsumura, T1
Ju, Q1
Lin, J1
Bierhaus, A1
Nawroth, P1
Hannak, D1
Neumaier, M1
Bergfeld, R1
Giardino, I1
Obrenovich, ME1
Monnier, VM1
YAMAMOTO, I1
Solimine, C1
Ape, AU1
Arora, S1
Lidor, A1
Abularrage, CJ1
Weiswasser, JM1
Nylen, E1
Kellicut, D1
Sidawy, AN1
Negrean, M1
Stratmann, B1
Gawlowski, T1
Horstmann, T1
Götting, C1
Kleesiek, K1
Mueller-Roesel, M1
Koschinsky, T1
Uribarri, J1
Vlassara, H1
Ahmed, N1
Thornalley, PJ2
Jahan, I1
Ng, R1
Schreier, K1
Porath, U1
Juhász, W1
Molnár, L1
Mészáros, T1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Impact of Thiamine Supplementation on Mortality in Septic Shock. A Controlled Before-and-after Study.[NCT05840718]80 participants (Anticipated)Observational2023-09-30Not yet recruiting
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients, A Retrospective Cohort Study[NCT04710329]78 participants (Actual)Observational2021-01-16Completed
Ascorbic Ccid, Hydrocortisone, and Thiamine in Sepsis and Septic Shock - A Randomized, Double-Blind, Placebo-Controlled Trial[NCT03389555]Phase 2/Phase 3205 participants (Actual)Interventional2018-02-09Completed
Corticosteroids to Reduce Inflammation in Severe Pancreatitis: A Randomized, Controlled Study[NCT05160506]Phase 286 participants (Anticipated)Interventional2022-03-06Recruiting
The Role of the Glucosamine Pathway and Reactive Oxygen Species in the Pathogenesis of Diabetic Complications[NCT00703989]21 participants (Actual)Interventional2005-02-28Completed
A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318]Phase 486 participants (Anticipated)Interventional2007-12-31Completed
Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System[NCT00446810]Phase 430 participants (Anticipated)Interventional2007-09-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

30-day Mortality

Mortality rate (NCT03389555)
Timeframe: Enrollment until 30-days after enrollment

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids35
Placebo29

Hospital Disposition: Survivors Discharged Home

Home hospital disposition in patients who survive to discharge (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days, whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids34
Placebo35

Hospital Mortality

Hospital mortality rate (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days. Whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids28
Placebo23

ICU Free Days

Number of days that the patient was not in the ICU. Timeframe listed below. (NCT03389555)
Timeframe: From enrollment until 28 days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids22
Placebo21

Intensive Care Unit (ICU) Mortality

ICU mortality rate (NCT03389555)
Timeframe: Enrollment until ICU discharge, death, or 30-days. Whichever comes first.

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids23
Placebo20

Number of Participants With Delirium

"Describes if patient has delirium as defined by the Confusion Assessment Method (CAM)-ICU. The CAM-ICU method requires that the patient have 3 features to qualify for delirium:~Acute Onset of Changes or Fluctuations in the Course of Mental Status (AND )~Inattention (AND)~Disorganized thinking (OR) Altered Level of Consciousness" (NCT03389555)
Timeframe: On day 3 (at approximately 72 hours) after the first study drug dose

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids31
Placebo35

Renal Failure

"Development of renal failure as defined by a Kidney Disease Improving Global Outcomes [KDIGO] stage 3 or higher. There are 3 stages in the KDIGO scale with stage 3 being the worst (corresponds to renal failure).~Stage 1- serum creatinine 1.5 to 1.9 times baseline OR an increase in serum creatinine ≥ 0.3 mg/dL OR urine output < 0.5ml/kg/hour for 6-12 hours. Stage 2- serum creatinine 2.0-2.9 times baseline OR urine output <0.5mg/kg/hour for ≥ 12 hours Stage 3- serum creatinine 3.0 times baseline (or serum creatinine of more than or equal to 4.0 mg/dl with an acute increase of at least 0.5 mg/dl) (OR) Urine output less than 0.3 ml/kg/hour for 24 hours or anuria for 12 hours or new renal replacement therapy" (NCT03389555)
Timeframe: Enrollment until 7-days or discharge from the ICU

InterventionParticipants (Count of Participants)
Vitamin C, Vitamin B1, Corticosteroids32
Placebo27

Shock Free Days

Days not receiving vasopressor (NCT03389555)
Timeframe: Vasopressor free days over the first 7-days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids5
Placebo4

Ventilator Free Days

Days not receiving invasive mechanical ventilation (NCT03389555)
Timeframe: Ventilator free days over the first 7-days after enrollment

InterventionDays (Median)
Vitamin C, Vitamin B1, Corticosteroids6
Placebo6

Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours

Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours. The SOFA score ranges from a minimum of 0 to a maximum of 24, with higher scores meaning worse outcomes. (NCT03389555)
Timeframe: Enrollment to 72-hours

,
InterventionUnits on a scale (Mean)
Enrollment SOFA score72 hour SOFA score
Placebo9.25.1
Vitamin C, Vitamin B1, Corticosteroids9.14.4

Reviews

5 reviews available for thiamine and Hyperglycemia

ArticleYear
The multifaceted therapeutic potential of benfotiamine.
    Pharmacological research, 2010, Volume: 61, Issue:6

    Topics: Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hyperglycemia; Hypoglycemic Ag

2010
Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease.
    International journal of clinical practice, 2011, Volume: 65, Issue:6

    Topics: Animals; Blood Glucose; Diabetic Angiopathies; Dietary Supplements; Endothelium, Vascular; Humans; H

2011
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:8

    Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie

2013
Advanced glycation endproducts: what is their relevance to diabetic complications?
    Diabetes, obesity & metabolism, 2007, Volume: 9, Issue:3

    Topics: Blood Glucose; Diabetes Complications; Glycation End Products, Advanced; Glycosylation; Humans; Hype

2007
[Congenital metabolic acidosis in the postnatal period].
    Deutsche medizinische Wochenschrift (1946), 1978, Jun-02, Volume: 103, Issue:22

    Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Fructose-1,6-Diphosphatase Deficiency; Glutarates; G

1978

Trials

7 trials available for thiamine and Hyperglycemia

ArticleYear
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Sexuality research & social policy : journal of NSRC : SR & SP, 2023, Apr-05

    Topics: Acute Kidney Injury; Adult; Aged; Albumins; Alloys; Amides; Amino Acids; Animals; Antineoplastic Com

2023
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
    JAMA, 2020, Aug-18, Volume: 324, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem

2020
Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence of benfotiamine treatment.
    Diabetes technology & therapeutics, 2013, Volume: 15, Issue:9

    Topics: Adult; Aged; Chelating Agents; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus, Type 2

2013
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
    Diabetologia, 2008, Volume: 51, Issue:10

    Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabe

2008
Effects of supplementation with multivitamin and mineral on blood pressure and C-reactive protein in obese Chinese women with increased cardiovascular disease risk.
    Asia Pacific journal of clinical nutrition, 2009, Volume: 18, Issue:1

    Topics: Adolescent; Blood Pressure; C-Reactive Protein; Calcium; China; Dietary Supplements; Double-Blind Me

2009
Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia.
    Annals of vascular surgery, 2006, Volume: 20, Issue:5

    Topics: Adult; Aged; Blood Flow Velocity; Blood Glucose; Brachial Artery; Diabetes Mellitus, Type 2; Endothe

2006
Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.
    Diabetes care, 2006, Volume: 29, Issue:9

    Topics: Adjuvants, Immunologic; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; En

2006

Other Studies

18 other studies available for thiamine and Hyperglycemia

ArticleYear
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions.
    Scientific reports, 2021, 09-23, Volume: 11, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Survival; Citric Acid Cycle; Diabetic Nephropathies

2021
The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide.
    Nutrition & diabetes, 2022, 06-20, Volume: 12, Issue:1

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Insulin; Male; Pan

2022
Endoplasmic Reticulum Stress in the Pathogenesis of Hyperglycemia Induced by Thiamine-Responsive Megaloblastic Anemia.
    Clinical laboratory, 2023, Sep-01, Volume: 69, Issue:9

    Topics: Anemia, Pernicious; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; HEK293 Cells;

2023
Allithiamine Alleviates Hyperglycaemia-Induced Endothelial Dysfunction.
    Nutrients, 2020, Jun-05, Volume: 12, Issue:6

    Topics: Anti-Inflammatory Agents; Antioxidants; Cytokines; Endothelium, Vascular; Garlic; Glycation End Prod

2020
Transketolase Activity but not Thiamine Membrane Transport Change in Response to Hyperglycaemia and Kidney Dysfunction.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2018, Volume: 126, Issue:4

    Topics: Adult; Aged; Biological Transport; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Erythrocytes;

2018
Severe type B lactic acidosis and insulin-resistant hyperglycemia related to cadaveric kidney transplantation.
    Journal of clinical anesthesia, 2018, Volume: 44

    Topics: Acidosis, Lactic; Blood Glucose; Hemofiltration; Humans; Hyperglycemia; Insulin; Kidney Failure, Chr

2018
Thiamine and its phosphate esters in relation to cardiometabolic risk factors in Saudi Arabs.
    European journal of medical research, 2013, Sep-23, Volume: 18

    Topics: Adult; Aging; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Diastole; Esters; Female; Hu

2013
Effect of thiamine on lipid profile in diabetic rats.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2009, Volume: 19, Issue:3

    Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Dyslipidemias; Hyperglycemia; Lipi

2009
Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine.
    Diabetes/metabolism research and reviews, 2009, Volume: 25, Issue:6

    Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cattle; Cell Line; Cells, Cultured; Di

2009
Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes.
    Diabetes/metabolism research and reviews, 2009, Volume: 25, Issue:7

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cytopr

2009
Effects of combined dietary chromium(III) propionate complex and thiamine supplementation on insulin sensitivity, blood biochemical indices, and mineral levels in high-fructose-fed rats.
    Biological trace element research, 2012, Volume: 150, Issue:1-3

    Topics: Animals; Chromium; Copper; Dietary Supplements; Fructose; Glucose Intolerance; Hyperglycemia; Hyperl

2012
Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage.
    Molecular and cellular biochemistry, 2013, Volume: 376, Issue:1-2

    Topics: Azaserine; Diabetes Mellitus; Glucose; Glycolysis; Hep G2 Cells; Hexosamines; Humans; Hyperglycemia;

2013
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
    Nature medicine, 2003, Volume: 9, Issue:3

    Topics: Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium

2003
Vitamin B1 blocks damage caused by hyperglycemia.
    Science of aging knowledge environment : SAGE KE, 2003, Mar-12, Volume: 2003, Issue:10

    Topics: Aging; Animals; Cattle; Diabetic Angiopathies; Glucose Intolerance; Glycation End Products, Advanced

2003
THIAMINE AS A NICOTINE ANTAGONIST.
    Japanese journal of pharmacology, 1963, Volume: 13

    Topics: Animals; Antimetabolites; Anura; Blood Pressure; Blood Pressure Determination; Bufonidae; Cats; Dogs

1963
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.
    The Journal of biological chemistry, 2006, Apr-07, Volume: 281, Issue:14

    Topics: Aldehyde Reductase; Animals; Cattle; Cell Culture Techniques; Chelating Agents; Diabetic Retinopathy

2006
Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.
    Journal of biochemistry, 2001, Volume: 129, Issue:4

    Topics: Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Erythrocytes; Glucose; Glycolysis; Humans;

2001
[Evaluation of glycosuria occurring in the postoperative stage].
    Zentralblatt fur Chirurgie, 1967, Volume: 92, Issue:26a Pt 1

    Topics: Carbohydrate Metabolism; Fructose; Glucose; Glycosuria; Humans; Hyperglycemia; Insulin; Postoperativ

1967