thiamine has been researched along with Hyperglycemia in 30 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the effect of thiamine disulfide (TD) on the pancreas in terms of hyperglycemia improvement and insulin sensitivity increase in diabetic male rats." | 8.12 | The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide. ( Meamar, R; Rad, MG; Sharifi, M; Soltani, N, 2022) |
| "Thiamine is a coenzyme important in intracellular glucose metabolism." | 6.72 | Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. ( Abularrage, CJ; Arora, S; Kellicut, D; Lidor, A; Nylen, E; Sidawy, AN; Weiswasser, JM, 2006) |
| "Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient." | 6.47 | Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. ( Cummings, MH; Laight, D; Page, GL, 2011) |
| "Insulin resistance is the first step in glucose intolerance and the development of type 2 diabetes mellitus, thus effective prevention strategies should also include dietary interventions to enhance insulin sensitivity." | 5.38 | Effects of combined dietary chromium(III) propionate complex and thiamine supplementation on insulin sensitivity, blood biochemical indices, and mineral levels in high-fructose-fed rats. ( Bogdański, P; Krejpcio, Z; Król, E; Michalak, S; Wójciak, RW, 2012) |
| "The present study investigated the effect of thiamine disulfide (TD) on the pancreas in terms of hyperglycemia improvement and insulin sensitivity increase in diabetic male rats." | 4.12 | The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide. ( Meamar, R; Rad, MG; Sharifi, M; Soltani, N, 2022) |
| "Low thiamine levels are associated with elevated blood glucose and hypertension in Saudi adults." | 3.79 | Thiamine and its phosphate esters in relation to cardiometabolic risk factors in Saudi Arabs. ( Abd-Alrahman, SH; Al-Attas, OS; Al-Daghri, NM; Alkharfy, KM; Alokail, MS; Sabico, S, 2013) |
| "To determine the effect of high dose thiamine on dyslipidemia in diabetic rats." | 3.75 | Effect of thiamine on lipid profile in diabetic rats. ( Ahmad, I; Malik, MM; Naveed, AK; Qamar, T; Raheem, A, 2009) |
| " We aimed at investigating whether pulsed exposure to different glucose concentrations influences apoptosis in human retinal pericytes (HRP) versus bovine retinal pericytes (BRP), with consequences on the onset of diabetic retinopathy, and the possible protective role of thiamine." | 3.75 | Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine. ( Beltramo, E; Berrone, E; Porta, M; Tarallo, S, 2009) |
| "In patients with septic shock, the combination of ascorbic acid, corticosteroids, and thiamine, compared with placebo, did not result in a statistically significant reduction in SOFA score during the first 72 hours after enrollment." | 2.94 | Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial. ( Andersen, LW; Becker, LB; Berg, KM; Chase, M; Cocchi, MN; Donnino, MW; Doshi, PB; Gong, J; Grossestreuer, AV; Hershey, M; Hilewitz, A; Hou, PC; Huang, DT; Korotun, M; McCannon, JB; Moskowitz, A; Ngo, L; Otero, RM; Sen, A; Sherwin, RL; Uduman, J, 2020) |
| "Male participants with and without type 1 diabetes were studied in the General Clinical Research Centre of the Albert Einstein College of Medicine." | 2.73 | Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. ( Brownlee, M; Du, X; Edelstein, D, 2008) |
| "Thiamine is a coenzyme important in intracellular glucose metabolism." | 2.72 | Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. ( Abularrage, CJ; Arora, S; Kellicut, D; Lidor, A; Nylen, E; Sidawy, AN; Weiswasser, JM, 2006) |
| "Thirteen people with type 2 diabetes were given a heat-processed test meal with a high AGE content (HAGE; 15." | 2.72 | Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. ( Gawlowski, T; Götting, C; Horstmann, T; Kleesiek, K; Koschinsky, T; Mueller-Roesel, M; Negrean, M; Stirban, A; Stratmann, B; Tschoepe, D; Uribarri, J; Vlassara, H, 2006) |
| "Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient." | 2.47 | Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease. ( Cummings, MH; Laight, D; Page, GL, 2011) |
| "Insulin resistance is the first step in glucose intolerance and the development of type 2 diabetes mellitus, thus effective prevention strategies should also include dietary interventions to enhance insulin sensitivity." | 1.38 | Effects of combined dietary chromium(III) propionate complex and thiamine supplementation on insulin sensitivity, blood biochemical indices, and mineral levels in high-fructose-fed rats. ( Bogdański, P; Krejpcio, Z; Król, E; Michalak, S; Wójciak, RW, 2012) |
| "Hyperglycemia is a causal factor in the development of the vascular complications of diabetes." | 1.33 | Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. ( Ape, AU; Beltramo, E; Berrone, E; Porta, M; Solimine, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (40.00) | 29.6817 |
| 2010's | 9 (30.00) | 24.3611 |
| 2020's | 6 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yako, H | 1 |
| Niimi, N | 1 |
| Kato, A | 1 |
| Takaku, S | 1 |
| Tatsumi, Y | 1 |
| Nishito, Y | 1 |
| Kato, K | 2 |
| Sango, K | 1 |
| Rad, MG | 1 |
| Sharifi, M | 1 |
| Meamar, R | 1 |
| Soltani, N | 1 |
| Dhanani, LY | 1 |
| Totton, RR | 1 |
| Jara-Quijada, E | 1 |
| Pérez-Won, M | 1 |
| Tabilo-Munizaga, G | 1 |
| Lemus-Mondaca, R | 1 |
| González-Cavieres, L | 1 |
| Palma-Acevedo, A | 1 |
| Herrera-Lavados, C | 1 |
| Milovanovic, S | 1 |
| Grzegorczyk, A | 1 |
| Świątek, Ł | 1 |
| Grzęda, A | 1 |
| Dębczak, A | 1 |
| Tyskiewicz, K | 1 |
| Konkol, M | 1 |
| Li, Y | 3 |
| Chang, P | 1 |
| Sankaran, S | 1 |
| Jang, H | 1 |
| Nie, Y | 1 |
| Zeng, A | 1 |
| Hussain, S | 1 |
| Wu, JY | 1 |
| Chen, X | 2 |
| Shi, L | 2 |
| Senapati, A | 1 |
| Chetri, BK | 1 |
| Mitra, S | 1 |
| Shelke, RG | 1 |
| Rangan, L | 1 |
| Chauhan, AS | 1 |
| Tiwari, M | 1 |
| Indoliya, Y | 1 |
| Mishra, SK | 1 |
| Lavania, UC | 1 |
| Chauhan, PS | 1 |
| Chakrabarty, D | 1 |
| Tripathi, RD | 1 |
| Akaputra, R | 1 |
| Hatta, M | 1 |
| Massi, MN | 1 |
| Djaharuddin, I | 1 |
| Bukhari, A | 1 |
| Aminuddin, A | 1 |
| Santoso, A | 1 |
| Natzir, R | 1 |
| Bahar, B | 1 |
| Fachri, M | 1 |
| Farsida, F | 1 |
| Fathimah, A | 1 |
| Ubaidah, FM | 1 |
| Sridiana, E | 1 |
| Dwiyanti, R | 1 |
| Syukri, A | 1 |
| Junita, AR | 1 |
| Febrianti, A | 1 |
| Primaguna, MR | 1 |
| Azhar, A | 1 |
| Rajaure, YS | 1 |
| Thapa, B | 1 |
| Budhathoki, L | 1 |
| Rana, SR | 1 |
| Khadka, M | 1 |
| Batchu, UR | 1 |
| Surapaneni, JR | 1 |
| Cheemalamarri, C | 1 |
| Mandava, K | 1 |
| Puvvada, N | 1 |
| Shetty, PR | 1 |
| Mv, S | 1 |
| Ranjbarian, P | 1 |
| Goudarzi, F | 1 |
| Akya, A | 1 |
| Heidarinia, H | 1 |
| Farasat, A | 1 |
| Rostamian, M | 1 |
| Suri, K | 1 |
| Rajput, N | 1 |
| Sharma, P | 1 |
| Omble, AD | 1 |
| Kulkarni, K | 1 |
| Gahlay, GK | 1 |
| Fernandez Garcia, E | 1 |
| Paudel, U | 1 |
| Noji, MC | 1 |
| Bowman, CE | 1 |
| Rustgi, AK | 1 |
| Pitarresi, JR | 1 |
| Wellen, KE | 1 |
| Arany, Z | 1 |
| Weissenrieder, JS | 1 |
| Foskett, JK | 1 |
| Lee, MS | 1 |
| Han, HJ | 1 |
| Choi, TI | 1 |
| Lee, KH | 1 |
| Baasankhuu, A | 1 |
| Kim, HT | 1 |
| Kim, CH | 1 |
| Redd, PS | 1 |
| Payero, L | 1 |
| Gilbert, DM | 1 |
| Page, CA | 1 |
| King, R | 1 |
| McAssey, EV | 1 |
| Bodie, D | 1 |
| Diaz, S | 1 |
| Hancock, CN | 1 |
| Lee, HS | 1 |
| Jung, S | 1 |
| Lee, SW | 1 |
| Kim, YT | 1 |
| Lee, J | 1 |
| Ren, T | 1 |
| Yu, Z | 1 |
| Yu, H | 1 |
| Deng, K | 1 |
| Wang, Z | 1 |
| Li, X | 1 |
| Wang, H | 1 |
| Wang, L | 2 |
| Xu, Y | 1 |
| Lascano, J | 1 |
| Riley, L | 1 |
| Khodayari, N | 1 |
| Brantly, M | 1 |
| Gupta, R | 1 |
| Pradhan, J | 1 |
| Haldar, A | 1 |
| Murapaka, C | 1 |
| Chandra Mondal, P | 1 |
| Gao, R | 1 |
| Dai, TY | 1 |
| Meng, Z | 1 |
| Sun, XF | 1 |
| Liu, DX | 1 |
| Shi, MM | 1 |
| Li, HR | 1 |
| Kang, X | 1 |
| Bi, B | 1 |
| Zhang, YT | 1 |
| Xu, TW | 1 |
| Yan, JM | 1 |
| Jiang, Q | 1 |
| Helmchen, G | 1 |
| Guo, H | 1 |
| Xiang, W | 1 |
| Fang, Y | 1 |
| Li, J | 4 |
| Lin, Y | 1 |
| An, X | 1 |
| Jiang, D | 1 |
| Cao, Q | 1 |
| Xu, F | 1 |
| Shiigi, H | 1 |
| Wang, W | 1 |
| Chen, Z | 1 |
| Akosman, I | 1 |
| Kumar, N | 1 |
| Mortenson, R | 1 |
| Lans, A | 1 |
| De La Garza Ramos, R | 1 |
| Eleswarapu, A | 1 |
| Yassari, R | 1 |
| Fourman, MS | 1 |
| Jana, S | 1 |
| Evans, EGB | 1 |
| Jang, HS | 1 |
| Zhang, S | 2 |
| Zhang, H | 1 |
| Rajca, A | 1 |
| Gordon, SE | 1 |
| Zagotta, WN | 1 |
| Stoll, S | 1 |
| Mehl, RA | 1 |
| Miller, S | 1 |
| Lee, DA | 1 |
| Muhimpundu, S | 1 |
| Maxwell, CA | 1 |
| Liu, Z | 1 |
| Shen, F | 1 |
| Tong, Q | 1 |
| Tang, M | 1 |
| Peng, M | 1 |
| Jiao, Z | 1 |
| Jiang, Y | 1 |
| Ao, L | 1 |
| Fu, W | 1 |
| Lv, X | 1 |
| Jiang, G | 1 |
| Hou, L | 1 |
| Tu, WC | 1 |
| McManamen, AM | 1 |
| Su, X | 1 |
| Jeacopello, I | 1 |
| Takezawa, MG | 1 |
| Hieber, DL | 1 |
| Hassan, GW | 1 |
| Lee, UN | 1 |
| Anana, EV | 1 |
| Locknane, MP | 1 |
| Stephenson, MW | 1 |
| Shinkawa, VAM | 1 |
| Wald, ER | 1 |
| DeMuri, GP | 1 |
| Adams, KN | 1 |
| Berthier, E | 1 |
| Thongpang, S | 1 |
| Theberge, AB | 1 |
| Jiang, L | 1 |
| Li, Z | 1 |
| Dong, Q | 1 |
| Rong, X | 1 |
| Dong, G | 1 |
| Huang, J | 1 |
| Liang, Y | 1 |
| Sun, S | 1 |
| Zhang, R | 1 |
| Miao, Z | 1 |
| Senju, C | 1 |
| Nakazawa, Y | 1 |
| Oso, T | 1 |
| Shimada, M | 1 |
| Matsuse, M | 1 |
| Tsujimoto, M | 1 |
| Masaki, T | 1 |
| Miyazaki, Y | 1 |
| Fukushima, S | 1 |
| Tateishi, S | 1 |
| Utani, A | 1 |
| Murota, H | 1 |
| Tanaka, K | 1 |
| Mitsutake, N | 1 |
| Moriwaki, S | 1 |
| Nishigori, C | 1 |
| Ogi, T | 1 |
| Liu, C | 1 |
| Zhang, X | 2 |
| Wang, B | 1 |
| Luo, Z | 1 |
| Qian, D | 1 |
| Liu, J | 1 |
| Waterhouse, GIN | 1 |
| Barbosa, M | 1 |
| Marques-Sá, J | 1 |
| Carvalho, C | 1 |
| Fernandes, V | 1 |
| Grilli, D | 1 |
| Smetana, V | 1 |
| Ahmed, SJ | 1 |
| Shtender, V | 1 |
| Pani, M | 1 |
| Manfrinetti, P | 1 |
| Mudring, AV | 1 |
| Kuang, Y | 1 |
| Yang, D | 1 |
| Gai, S | 1 |
| He, F | 1 |
| An, B | 1 |
| Yang, P | 1 |
| Notini, L | 1 |
| Schulz, K | 1 |
| Kubeneck, LJ | 1 |
| Grigg, ARC | 1 |
| Rothwell, KA | 1 |
| Fantappiè, G | 1 |
| ThomasArrigo, LK | 1 |
| Kretzschmar, R | 1 |
| Siswanto, FM | 1 |
| Okukawa, K | 1 |
| Tamura, A | 1 |
| Oguro, A | 1 |
| Imaoka, S | 1 |
| Kim, CG | 1 |
| Jung, M | 1 |
| Kim, HS | 1 |
| Lee, CK | 1 |
| Jeung, HC | 1 |
| Koo, DH | 1 |
| Bae, WK | 1 |
| Zang, DY | 1 |
| Kim, BJ | 1 |
| Kim, H | 1 |
| Yun, UJ | 1 |
| Che, J | 1 |
| Park, S | 1 |
| Kim, TS | 1 |
| Kwon, WS | 1 |
| Park, J | 1 |
| Cho, SW | 1 |
| Nam, CM | 1 |
| Chung, HC | 1 |
| Rha, SY | 1 |
| Colombo, N | 1 |
| Van Gorp, T | 1 |
| Matulonis, UA | 1 |
| Oaknin, A | 1 |
| Grisham, RN | 1 |
| Fleming, GF | 1 |
| Olawaiye, AB | 1 |
| Nguyen, DD | 1 |
| Greenstein, AE | 1 |
| Custodio, JM | 1 |
| Pashova, HI | 1 |
| Tudor, IC | 1 |
| Lorusso, D | 1 |
| Zhou, F | 1 |
| Jiang, Z | 1 |
| Liang, H | 1 |
| Ru, S | 1 |
| Bettiol, AA | 1 |
| Gao, W | 1 |
| Lipsyc-Sharf, M | 1 |
| Jain, E | 1 |
| Collins, LC | 1 |
| Rosenberg, SM | 1 |
| Ruddy, KJ | 1 |
| Tamimi, RM | 1 |
| Schapira, L | 1 |
| Come, SE | 1 |
| Peppercorn, JM | 1 |
| Borges, VF | 1 |
| Warner, E | 1 |
| Snow, C | 1 |
| Krop, IE | 1 |
| Kim, D | 1 |
| Weiss, J | 1 |
| Zanudo, JGT | 1 |
| Partridge, AH | 1 |
| Wagle, N | 1 |
| Waks, AG | 1 |
| Moskowitz, A | 2 |
| Berg, KM | 2 |
| Grossestreuer, AV | 2 |
| Balaji, L | 1 |
| Liu, X | 1 |
| Cocchi, MN | 2 |
| Chase, M | 2 |
| Gong, MN | 1 |
| Gong, J | 2 |
| Parikh, SM | 1 |
| Ngo, L | 2 |
| Berlin, N | 1 |
| Donnino, MW | 2 |
| Zhou, Y | 1 |
| Chen, Q | 1 |
| Zhong, S | 1 |
| Liu, H | 1 |
| Koh, K | 1 |
| Chen, H | 1 |
| He, J | 1 |
| Chen, J | 1 |
| Liu, S | 1 |
| Lin, L | 1 |
| Zhang, Y | 1 |
| Xiao, S | 1 |
| Cao, S | 1 |
| Yan, B | 2 |
| Deng, J | 1 |
| Gu, J | 1 |
| Tao, Y | 1 |
| Huang, C | 1 |
| Lai, C | 1 |
| Yong, Q | 1 |
| Shen, Y | 1 |
| Gong, Z | 1 |
| Cao, J | 1 |
| Mao, W | 1 |
| Yao, Y | 1 |
| Zhao, J | 1 |
| Li, Q | 1 |
| Liu, K | 1 |
| Liu, B | 1 |
| Feng, S | 1 |
| Chandran, V | 1 |
| Kunjan, C | 1 |
| Veerapandian, V | 1 |
| Kannan, R | 1 |
| Zhang, T | 1 |
| von Gunten, U | 1 |
| Caruso, FR | 1 |
| Goulart, CDL | 1 |
| Jr, JCB | 1 |
| de Oliveira, CR | 1 |
| Mendes, RG | 1 |
| Arena, R | 1 |
| Borghi-Silva, A | 1 |
| Carrasco-Nuñes, N | 1 |
| Romano, M | 1 |
| Cabeza, M | 1 |
| Jiang, B | 1 |
| Chen, D | 1 |
| Zhao, C | 1 |
| Ma, Y | 1 |
| Yang, W | 1 |
| Shen, X | 1 |
| Satheeshkumar, K | 1 |
| Saravanakumar, P | 1 |
| Kalavathi, A | 1 |
| Vennila, KN | 1 |
| Elango, KP | 1 |
| Mues Genannt Koers, L | 1 |
| Prevost, D | 1 |
| Paulssen, E | 1 |
| Hoehr, C | 1 |
| Ulhassan, Z | 1 |
| Yang, S | 1 |
| He, D | 1 |
| Khan, AR | 1 |
| Salam, A | 1 |
| Azhar, W | 1 |
| Muhammad, S | 1 |
| Ali, S | 1 |
| Hamid, Y | 1 |
| Khan, I | 1 |
| Sheteiwy, MS | 1 |
| Zhou, W | 1 |
| Wang, X | 1 |
| Xie, Q | 1 |
| Wang, Y | 1 |
| Lü, H | 1 |
| Fu, M | 1 |
| Wang, D | 1 |
| Qin, YY | 1 |
| Ye, Y | 1 |
| Lin, FQ | 1 |
| Biró, A | 1 |
| Markovics, A | 1 |
| Fazekas, MÉ | 1 |
| Fidler, G | 1 |
| Szalóki, G | 1 |
| Paholcsek, M | 1 |
| Lukács, J | 1 |
| Stündl, L | 1 |
| Remenyik, J | 1 |
| Huang, DT | 1 |
| Hou, PC | 1 |
| Doshi, PB | 1 |
| Andersen, LW | 1 |
| Sherwin, RL | 1 |
| McCannon, JB | 1 |
| Hershey, M | 1 |
| Hilewitz, A | 1 |
| Korotun, M | 1 |
| Becker, LB | 1 |
| Otero, RM | 1 |
| Uduman, J | 1 |
| Sen, A | 1 |
| Chalásová, K | 1 |
| Pácal, L | 1 |
| Pleskačová, A | 1 |
| Knopfová, L | 1 |
| Řehořová, J | 1 |
| Tomandlová, M | 1 |
| Tomandl, J | 1 |
| Kaňková, K | 1 |
| Souki, FG | 1 |
| Ghaffaripour, S | 1 |
| Martinez-Lu, K | 1 |
| Mahmoudi, H | 1 |
| Stirban, A | 2 |
| Pop, A | 1 |
| Fischer, A | 1 |
| Heckermann, S | 1 |
| Tschoepe, D | 2 |
| Al-Daghri, NM | 1 |
| Al-Attas, OS | 1 |
| Alkharfy, KM | 1 |
| Alokail, MS | 1 |
| Abd-Alrahman, SH | 1 |
| Sabico, S | 1 |
| Du, X | 2 |
| Edelstein, D | 2 |
| Brownlee, M | 2 |
| Naveed, AK | 1 |
| Qamar, T | 1 |
| Ahmad, I | 1 |
| Raheem, A | 1 |
| Malik, MM | 1 |
| Wang, C | 1 |
| Zhu, K | 1 |
| Dong, YM | 1 |
| Sun, CH | 1 |
| Beltramo, E | 3 |
| Berrone, E | 3 |
| Tarallo, S | 2 |
| Porta, M | 3 |
| Nizheradze, K | 1 |
| Balakumar, P | 1 |
| Rohilla, A | 1 |
| Krishan, P | 1 |
| Solairaj, P | 1 |
| Thangathirupathi, A | 1 |
| Page, GL | 1 |
| Laight, D | 1 |
| Cummings, MH | 1 |
| Król, E | 1 |
| Krejpcio, Z | 1 |
| Michalak, S | 1 |
| Wójciak, RW | 1 |
| Bogdański, P | 1 |
| Engelen, L | 1 |
| Stehouwer, CD | 1 |
| Schalkwijk, CG | 1 |
| Teodoro, JS | 1 |
| Gomes, AP | 1 |
| Varela, AT | 1 |
| Duarte, FV | 1 |
| Rolo, AP | 1 |
| Palmeira, CM | 1 |
| Hammes, HP | 1 |
| Taguchi, T | 1 |
| Matsumura, T | 1 |
| Ju, Q | 1 |
| Lin, J | 1 |
| Bierhaus, A | 1 |
| Nawroth, P | 1 |
| Hannak, D | 1 |
| Neumaier, M | 1 |
| Bergfeld, R | 1 |
| Giardino, I | 1 |
| Obrenovich, ME | 1 |
| Monnier, VM | 1 |
| YAMAMOTO, I | 1 |
| Solimine, C | 1 |
| Ape, AU | 1 |
| Arora, S | 1 |
| Lidor, A | 1 |
| Abularrage, CJ | 1 |
| Weiswasser, JM | 1 |
| Nylen, E | 1 |
| Kellicut, D | 1 |
| Sidawy, AN | 1 |
| Negrean, M | 1 |
| Stratmann, B | 1 |
| Gawlowski, T | 1 |
| Horstmann, T | 1 |
| Götting, C | 1 |
| Kleesiek, K | 1 |
| Mueller-Roesel, M | 1 |
| Koschinsky, T | 1 |
| Uribarri, J | 1 |
| Vlassara, H | 1 |
| Ahmed, N | 1 |
| Thornalley, PJ | 2 |
| Jahan, I | 1 |
| Ng, R | 1 |
| Schreier, K | 1 |
| Porath, U | 1 |
| Juhász, W | 1 |
| Molnár, L | 1 |
| Mészáros, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Thiamine Supplementation on Mortality in Septic Shock. A Controlled Before-and-after Study.[NCT05840718] | 80 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients, A Retrospective Cohort Study[NCT04710329] | 78 participants (Actual) | Observational | 2021-01-16 | Completed | |||
| Ascorbic Ccid, Hydrocortisone, and Thiamine in Sepsis and Septic Shock - A Randomized, Double-Blind, Placebo-Controlled Trial[NCT03389555] | Phase 2/Phase 3 | 205 participants (Actual) | Interventional | 2018-02-09 | Completed | ||
| Corticosteroids to Reduce Inflammation in Severe Pancreatitis: A Randomized, Controlled Study[NCT05160506] | Phase 2 | 86 participants (Anticipated) | Interventional | 2022-03-06 | Recruiting | ||
| The Role of the Glucosamine Pathway and Reactive Oxygen Species in the Pathogenesis of Diabetic Complications[NCT00703989] | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | |||
| A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318] | Phase 4 | 86 participants (Anticipated) | Interventional | 2007-12-31 | Completed | ||
| Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System[NCT00446810] | Phase 4 | 30 participants (Anticipated) | Interventional | 2007-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Mortality rate (NCT03389555)
Timeframe: Enrollment until 30-days after enrollment
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 35 |
| Placebo | 29 |
Home hospital disposition in patients who survive to discharge (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days, whichever comes first.
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 34 |
| Placebo | 35 |
Hospital mortality rate (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days. Whichever comes first.
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 28 |
| Placebo | 23 |
Number of days that the patient was not in the ICU. Timeframe listed below. (NCT03389555)
Timeframe: From enrollment until 28 days after enrollment
| Intervention | Days (Median) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 22 |
| Placebo | 21 |
ICU mortality rate (NCT03389555)
Timeframe: Enrollment until ICU discharge, death, or 30-days. Whichever comes first.
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 23 |
| Placebo | 20 |
"Describes if patient has delirium as defined by the Confusion Assessment Method (CAM)-ICU. The CAM-ICU method requires that the patient have 3 features to qualify for delirium:~Acute Onset of Changes or Fluctuations in the Course of Mental Status (AND )~Inattention (AND)~Disorganized thinking (OR) Altered Level of Consciousness" (NCT03389555)
Timeframe: On day 3 (at approximately 72 hours) after the first study drug dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 31 |
| Placebo | 35 |
"Development of renal failure as defined by a Kidney Disease Improving Global Outcomes [KDIGO] stage 3 or higher. There are 3 stages in the KDIGO scale with stage 3 being the worst (corresponds to renal failure).~Stage 1- serum creatinine 1.5 to 1.9 times baseline OR an increase in serum creatinine ≥ 0.3 mg/dL OR urine output < 0.5ml/kg/hour for 6-12 hours. Stage 2- serum creatinine 2.0-2.9 times baseline OR urine output <0.5mg/kg/hour for ≥ 12 hours Stage 3- serum creatinine 3.0 times baseline (or serum creatinine of more than or equal to 4.0 mg/dl with an acute increase of at least 0.5 mg/dl) (OR) Urine output less than 0.3 ml/kg/hour for 24 hours or anuria for 12 hours or new renal replacement therapy" (NCT03389555)
Timeframe: Enrollment until 7-days or discharge from the ICU
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 32 |
| Placebo | 27 |
Days not receiving vasopressor (NCT03389555)
Timeframe: Vasopressor free days over the first 7-days after enrollment
| Intervention | Days (Median) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 5 |
| Placebo | 4 |
Days not receiving invasive mechanical ventilation (NCT03389555)
Timeframe: Ventilator free days over the first 7-days after enrollment
| Intervention | Days (Median) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 6 |
| Placebo | 6 |
Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours. The SOFA score ranges from a minimum of 0 to a maximum of 24, with higher scores meaning worse outcomes. (NCT03389555)
Timeframe: Enrollment to 72-hours
| Intervention | Units on a scale (Mean) | |
|---|---|---|
| Enrollment SOFA score | 72 hour SOFA score | |
| Placebo | 9.2 | 5.1 |
| Vitamin C, Vitamin B1, Corticosteroids | 9.1 | 4.4 |
5 reviews available for thiamine and Hyperglycemia
| Article | Year |
|---|---|
The multifaceted therapeutic potential of benfotiamine.
Topics: Animals; Diabetes Mellitus; Glycation End Products, Advanced; Humans; Hyperglycemia; Hypoglycemic Ag | 2010 |
Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease.
Topics: Animals; Blood Glucose; Diabetic Angiopathies; Dietary Supplements; Endothelium, Vascular; Humans; H | 2011 |
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2013 |
Advanced glycation endproducts: what is their relevance to diabetic complications?
Topics: Blood Glucose; Diabetes Complications; Glycation End Products, Advanced; Glycosylation; Humans; Hype | 2007 |
[Congenital metabolic acidosis in the postnatal period].
Topics: Acidosis; Amino Acid Metabolism, Inborn Errors; Fructose-1,6-Diphosphatase Deficiency; Glutarates; G | 1978 |
7 trials available for thiamine and Hyperglycemia
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Acute Kidney Injury; Adult; Aged; Albumins; Alloys; Amides; Amino Acids; Animals; Antineoplastic Com | 2023 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence of benfotiamine treatment.
Topics: Adult; Aged; Chelating Agents; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus, Type 2 | 2013 |
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabe | 2008 |
Effects of supplementation with multivitamin and mineral on blood pressure and C-reactive protein in obese Chinese women with increased cardiovascular disease risk.
Topics: Adolescent; Blood Pressure; C-Reactive Protein; Calcium; China; Dietary Supplements; Double-Blind Me | 2009 |
Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia.
Topics: Adult; Aged; Blood Flow Velocity; Blood Glucose; Brachial Artery; Diabetes Mellitus, Type 2; Endothe | 2006 |
Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.
Topics: Adjuvants, Immunologic; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; En | 2006 |
18 other studies available for thiamine and Hyperglycemia
| Article | Year |
|---|---|
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Survival; Citric Acid Cycle; Diabetic Nephropathies | 2021 |
The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Insulin; Male; Pan | 2022 |
Endoplasmic Reticulum Stress in the Pathogenesis of Hyperglycemia Induced by Thiamine-Responsive Megaloblastic Anemia.
Topics: Anemia, Pernicious; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; HEK293 Cells; | 2023 |
Allithiamine Alleviates Hyperglycaemia-Induced Endothelial Dysfunction.
Topics: Anti-Inflammatory Agents; Antioxidants; Cytokines; Endothelium, Vascular; Garlic; Glycation End Prod | 2020 |
Transketolase Activity but not Thiamine Membrane Transport Change in Response to Hyperglycaemia and Kidney Dysfunction.
Topics: Adult; Aged; Biological Transport; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Erythrocytes; | 2018 |
Severe type B lactic acidosis and insulin-resistant hyperglycemia related to cadaveric kidney transplantation.
Topics: Acidosis, Lactic; Blood Glucose; Hemofiltration; Humans; Hyperglycemia; Insulin; Kidney Failure, Chr | 2018 |
Thiamine and its phosphate esters in relation to cardiometabolic risk factors in Saudi Arabs.
Topics: Adult; Aging; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Diastole; Esters; Female; Hu | 2013 |
Effect of thiamine on lipid profile in diabetic rats.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Dyslipidemias; Hyperglycemia; Lipi | 2009 |
Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cattle; Cell Line; Cells, Cultured; Di | 2009 |
Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cytopr | 2009 |
Effects of combined dietary chromium(III) propionate complex and thiamine supplementation on insulin sensitivity, blood biochemical indices, and mineral levels in high-fructose-fed rats.
Topics: Animals; Chromium; Copper; Dietary Supplements; Fructose; Glucose Intolerance; Hyperglycemia; Hyperl | 2012 |
Uncovering the beginning of diabetes: the cellular redox status and oxidative stress as starting players in hyperglycemic damage.
Topics: Azaserine; Diabetes Mellitus; Glucose; Glycolysis; Hep G2 Cells; Hexosamines; Humans; Hyperglycemia; | 2013 |
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Topics: Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium | 2003 |
Vitamin B1 blocks damage caused by hyperglycemia.
Topics: Aging; Animals; Cattle; Diabetic Angiopathies; Glucose Intolerance; Glycation End Products, Advanced | 2003 |
THIAMINE AS A NICOTINE ANTAGONIST.
Topics: Animals; Antimetabolites; Anura; Blood Pressure; Blood Pressure Determination; Bufonidae; Cats; Dogs | 1963 |
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.
Topics: Aldehyde Reductase; Animals; Cattle; Cell Culture Techniques; Chelating Agents; Diabetic Retinopathy | 2006 |
Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitro.
Topics: Deoxyglucose; Diabetes Complications; Diabetes Mellitus; Erythrocytes; Glucose; Glycolysis; Humans; | 2001 |
[Evaluation of glycosuria occurring in the postoperative stage].
Topics: Carbohydrate Metabolism; Fructose; Glucose; Glycosuria; Humans; Hyperglycemia; Insulin; Postoperativ | 1967 |