thiamine has been researched along with Health Care Associated Infection in 1 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Excerpt | Relevance | Reference |
---|---|---|
"In patients with septic shock, the combination of ascorbic acid, corticosteroids, and thiamine, compared with placebo, did not result in a statistically significant reduction in SOFA score during the first 72 hours after enrollment." | 2.94 | Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial. ( Andersen, LW; Becker, LB; Berg, KM; Chase, M; Cocchi, MN; Donnino, MW; Doshi, PB; Gong, J; Grossestreuer, AV; Hershey, M; Hilewitz, A; Hou, PC; Huang, DT; Korotun, M; McCannon, JB; Moskowitz, A; Ngo, L; Otero, RM; Sen, A; Sherwin, RL; Uduman, J, 2020) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (100.00) | 2.80 |
Authors | Studies |
---|---|
Moskowitz, A | 1 |
Huang, DT | 1 |
Hou, PC | 1 |
Gong, J | 1 |
Doshi, PB | 1 |
Grossestreuer, AV | 1 |
Andersen, LW | 1 |
Ngo, L | 1 |
Sherwin, RL | 1 |
Berg, KM | 1 |
Chase, M | 1 |
Cocchi, MN | 1 |
McCannon, JB | 1 |
Hershey, M | 1 |
Hilewitz, A | 1 |
Korotun, M | 1 |
Becker, LB | 1 |
Otero, RM | 1 |
Uduman, J | 1 |
Sen, A | 1 |
Donnino, MW | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Impact of Thiamine Supplementation on Mortality in Septic Shock. A Controlled Before-and-after Study.[NCT05840718] | 80 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients, A Retrospective Cohort Study[NCT04710329] | 78 participants (Actual) | Observational | 2021-01-16 | Completed | |||
Ascorbic Ccid, Hydrocortisone, and Thiamine in Sepsis and Septic Shock - A Randomized, Double-Blind, Placebo-Controlled Trial[NCT03389555] | Phase 2/Phase 3 | 205 participants (Actual) | Interventional | 2018-02-09 | Completed | ||
Corticosteroids to Reduce Inflammation in Severe Pancreatitis: A Randomized, Controlled Study[NCT05160506] | Phase 2 | 86 participants (Anticipated) | Interventional | 2022-03-06 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Mortality rate (NCT03389555)
Timeframe: Enrollment until 30-days after enrollment
Intervention | Participants (Count of Participants) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 35 |
Placebo | 29 |
Home hospital disposition in patients who survive to discharge (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days, whichever comes first.
Intervention | Participants (Count of Participants) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 34 |
Placebo | 35 |
Hospital mortality rate (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days. Whichever comes first.
Intervention | Participants (Count of Participants) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 28 |
Placebo | 23 |
Number of days that the patient was not in the ICU. Timeframe listed below. (NCT03389555)
Timeframe: From enrollment until 28 days after enrollment
Intervention | Days (Median) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 22 |
Placebo | 21 |
ICU mortality rate (NCT03389555)
Timeframe: Enrollment until ICU discharge, death, or 30-days. Whichever comes first.
Intervention | Participants (Count of Participants) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 23 |
Placebo | 20 |
"Describes if patient has delirium as defined by the Confusion Assessment Method (CAM)-ICU. The CAM-ICU method requires that the patient have 3 features to qualify for delirium:~Acute Onset of Changes or Fluctuations in the Course of Mental Status (AND )~Inattention (AND)~Disorganized thinking (OR) Altered Level of Consciousness" (NCT03389555)
Timeframe: On day 3 (at approximately 72 hours) after the first study drug dose
Intervention | Participants (Count of Participants) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 31 |
Placebo | 35 |
"Development of renal failure as defined by a Kidney Disease Improving Global Outcomes [KDIGO] stage 3 or higher. There are 3 stages in the KDIGO scale with stage 3 being the worst (corresponds to renal failure).~Stage 1- serum creatinine 1.5 to 1.9 times baseline OR an increase in serum creatinine ≥ 0.3 mg/dL OR urine output < 0.5ml/kg/hour for 6-12 hours. Stage 2- serum creatinine 2.0-2.9 times baseline OR urine output <0.5mg/kg/hour for ≥ 12 hours Stage 3- serum creatinine 3.0 times baseline (or serum creatinine of more than or equal to 4.0 mg/dl with an acute increase of at least 0.5 mg/dl) (OR) Urine output less than 0.3 ml/kg/hour for 24 hours or anuria for 12 hours or new renal replacement therapy" (NCT03389555)
Timeframe: Enrollment until 7-days or discharge from the ICU
Intervention | Participants (Count of Participants) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 32 |
Placebo | 27 |
Days not receiving vasopressor (NCT03389555)
Timeframe: Vasopressor free days over the first 7-days after enrollment
Intervention | Days (Median) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 5 |
Placebo | 4 |
Days not receiving invasive mechanical ventilation (NCT03389555)
Timeframe: Ventilator free days over the first 7-days after enrollment
Intervention | Days (Median) |
---|---|
Vitamin C, Vitamin B1, Corticosteroids | 6 |
Placebo | 6 |
Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours. The SOFA score ranges from a minimum of 0 to a maximum of 24, with higher scores meaning worse outcomes. (NCT03389555)
Timeframe: Enrollment to 72-hours
Intervention | Units on a scale (Mean) | |
---|---|---|
Enrollment SOFA score | 72 hour SOFA score | |
Placebo | 9.2 | 5.1 |
Vitamin C, Vitamin B1, Corticosteroids | 9.1 | 4.4 |
1 trial available for thiamine and Health Care Associated Infection
Article | Year |
---|---|
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |
Effect of Ascorbic Acid, Corticosteroids, and Thiamine on Organ Injury in Septic Shock: The ACTS Randomized Clinical Trial.
Topics: Adrenal Cortex Hormones; Adult; Aged; Ascorbic Acid; Cross Infection; Drug Therapy, Combination; Fem | 2020 |