thiamine has been researched along with Friedreich Disease in 8 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Some observations indicate that all symptoms of FRDA ataxia could be the manifestation of a thiamine deficiency because of enzymatic abnormalities." | 7.79 | High-dose thiamine improves the symptoms of Friedreich's ataxia. ( Costantini, A; D'Agostino, S; Giorgi, R; Pala, MI, 2013) |
| "Thiamine (vitamin B1) is a cofactor of fundamental enzymes of cell energetic metabolism; its deficiency causes disorders affecting both the peripheral and central nervous system." | 5.43 | Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia. ( Brusco, A; Cavalieri, S; Colangeli, M; Costantini, A; Fancellu, R; Laureti, T; Pala, MI; Pozzi, E; Salvarani, S; Serrati, C, 2016) |
| " Some observations indicate that all symptoms of FRDA ataxia could be the manifestation of a thiamine deficiency because of enzymatic abnormalities." | 3.79 | High-dose thiamine improves the symptoms of Friedreich's ataxia. ( Costantini, A; D'Agostino, S; Giorgi, R; Pala, MI, 2013) |
| "Thiamine (vitamin B1) is a cofactor of fundamental enzymes of cell energetic metabolism; its deficiency causes disorders affecting both the peripheral and central nervous system." | 1.43 | Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia. ( Brusco, A; Cavalieri, S; Colangeli, M; Costantini, A; Fancellu, R; Laureti, T; Pala, MI; Pozzi, E; Salvarani, S; Serrati, C, 2016) |
| "in Friedreich's ataxia (FA) and olivopontocerebellar atrophy (OPCA) are discussed in relation to (i) the serotoninergic theory; (ii) the excitotoxic action of glutamate; and (iii) cerebrospinal fluid thiamine deficiency in ataxic patients." | 1.30 | The treatment of spinocerebellar ataxias: facts and hypotheses. ( Botez, MI; Botez-Marquard, T; Lalonde, R; Marchand, L; Mayer, P; Reader, TA, 1998) |
| "Both OPCA and Friedreich's ataxia patients presented significantly lower cerebrospinal fluid thiamine levels than their controls (p less than 0." | 1.28 | Thiamine status in inherited degenerative ataxias. ( Botez, MI; Pedraza, OL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Costantini, A | 2 |
| Giorgi, R | 1 |
| D'Agostino, S | 1 |
| Pala, MI | 2 |
| Laureti, T | 1 |
| Colangeli, M | 1 |
| Cavalieri, S | 1 |
| Pozzi, E | 1 |
| Brusco, A | 1 |
| Salvarani, S | 1 |
| Serrati, C | 1 |
| Fancellu, R | 1 |
| Bettendorff, L | 1 |
| Mastrogiacomo, F | 1 |
| LaMarche, J | 1 |
| Dozić, S | 1 |
| Kish, SJ | 1 |
| Botez, MI | 4 |
| Mayer, P | 2 |
| Bellemare, F | 1 |
| Couture, J | 1 |
| Botez-Marquard, T | 1 |
| Marchand, L | 1 |
| Lalonde, R | 1 |
| Reader, TA | 1 |
| Young, SN | 1 |
| Ngo, TT | 1 |
| Tunnicliff, G | 1 |
| Yam, CF | 1 |
| Charbonneau, M | 1 |
| Barbeau, A | 1 |
| Pedraza, OL | 1 |
8 other studies available for thiamine and Friedreich Disease
| Article | Year |
|---|---|
High-dose thiamine improves the symptoms of Friedreich's ataxia.
Topics: Adult; Ataxia; Female; Friedreich Ataxia; Humans; Male; Thiamine; Thiamine Deficiency; Vitamin B Com | 2013 |
Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia.
Topics: Adult; Analysis of Variance; Echocardiography; Female; Friedreich Ataxia; Gene Expression; Humans; L | 2016 |
Brain levels of thiamine and its phosphate esters in Friedreich's ataxia and spinocerebellar ataxia type 1.
Topics: Adolescent; Adult; Cerebellar Cortex; Cerebral Cortex; Child; Child, Preschool; Female; Friedreich A | 1996 |
Can we treat respiratory failure in Friedreich ataxia?
Topics: 5-Hydroxytryptophan; Adult; Amantadine; Dopamine Agents; Friedreich Ataxia; Humans; Male; Respirator | 1997 |
The treatment of spinocerebellar ataxias: facts and hypotheses.
Topics: Animals; Friedreich Ataxia; Humans; Models, Neurological; Olivopontocerebellar Atrophies; Receptors, | 1998 |
Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias.
Topics: Adult; Aged; Female; Friedreich Ataxia; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Magneti | 2001 |
The inhibition of human plasma acetylcholinesterase by some naturally occurring compounds.
Topics: Acetylcholinesterase; Adolescent; Adult; Carnitine; Child; Cholinesterase Inhibitors; Female; Friedr | 1978 |
Thiamine status in inherited degenerative ataxias.
Topics: Adult; Female; Friedreich Ataxia; Humans; Male; Olivopontocerebellar Atrophies; Spinocerebellar Dege | 1992 |