Page last updated: 2024-10-20

thiamine and Electrolytes

thiamine has been researched along with Electrolytes in 27 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)

Research Excerpts

ExcerptRelevanceReference
" The initial measurement of thiamine level and serum electrolytes, including phosphate and magnesium, their supplementation if necessary, and a slow increase in nutritional intake along with close monitoring of serum electrolytes play an important role."4.98[Refeeding syndrome : Pathophysiology, risk factors, prevention, and treatment]. ( Diekmann, R; Fleiter, O; Fricke, L; Janssen, G; Kreilkamp, A; Marburger, C; Modreker, MK; Nels, S; Pourhassan, M; Schaefer, R; Volkert, D; Willschrei, HP; Wirth, R, 2018)
"The effect of high dietary sulfur (S) supplementation on blood thiamine (B1) concentration, biochemical indices of liver, muscle and kidney damage and selected plasma electrolytes was studied in six sheep."3.67Sulfur-induced polioencephalomalacia in sheep: some biochemical changes. ( Christensen, DA; Gooneratne, SR; Olkowski, AA, 1989)
"If alcoholic ketoacidosis is suspected, dextrose-containing fluids are recommended over normal saline."2.53Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU. ( Adkins, DA; Cook, AM; Flannery, AH, 2016)
"The objective of this study was to determine the relationship between glucose dosage in parenteral nutrition and reductions in levels of body thiamine in rats."1.51Influence of Glucose Dosage in Parenteral Nutrition on Body Thiamine Levels in Rats. ( Harada, D; Nakayama, M, 2019)
"Low thiamine levels were infrequent affecting 3/29 (10%)."1.40Refeeding syndrome is uncommon in alcoholics admitted to a hospital detoxification unit. ( Gilmour, M; Manning, S; Robinson, GM; Weatherall, M, 2014)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199016 (59.26)18.7374
1990's3 (11.11)18.2507
2000's1 (3.70)29.6817
2010's6 (22.22)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Bradley, C1
Hansen, A1
Levy, P1
Hashim, E1
Wirth, R1
Diekmann, R1
Janssen, G1
Fleiter, O1
Fricke, L1
Kreilkamp, A1
Modreker, MK1
Marburger, C1
Nels, S1
Pourhassan, M1
Schaefer, R1
Willschrei, HP1
Volkert, D1
Harada, D1
Nakayama, M1
Manning, S1
Gilmour, M1
Weatherall, M1
Robinson, GM1
Uccello-Barretta, G1
Balzano, F1
Aiello, F1
Falugiani, N1
Desideri, I1
Flannery, AH1
Adkins, DA1
Cook, AM1
Baś, B1
Jakubowska, M1
Górski, Ł1
PICCOLI, P1
FERRARI, M1
DANIELE, E1
Okudaira, K1
PECORA, LJ1
O'Hara, TM1
Bennett, L1
McCoy, CP1
Jack, SW1
Fleming, S1
Allwood, MC1
Martin, H1
Yoshino, M1
Aoki, K1
Akeda, H1
Hashimoto, K1
Ikeda, T1
Inoue, F1
Ito, M1
Kawamura, M1
Kohno, Y1
Koga, Y1
Kuroda, Y1
Maesaka, H1
Murakamisoda, H1
Sugiyama, N1
Suzuki, Y1
Yano, S1
Yoshioka, A1
Talbott, GD1
Schmid, F1
Christeller, S1
Rehm, W1
Wysokiński, A1
Struzak-Wysokińska, M1
Gooneratne, SR1
Olkowski, AA1
Christensen, DA1
Savina, AS1
Dvorina, VM1
Carstensen, JT1
Girolami, M1
Mizuhira, B1
Loew, FM1
Dunlop, RH1
Christian, RG1
White, JR1
Kaim, SC1
Caccuri, S1
Fati, S1
Sauli, M1
D'Alessandro, R1
Faelli, U1
Violani, M1
Bonazzi, L1
Sireci, V1
Franchi, G1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Thiamine Administration After Cardiac Surgery Trial[NCT04641104]Phase 4200 participants (Actual)Interventional2020-11-20Completed
Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.[NCT03422159]Phase 2140 participants (Actual)Interventional2018-02-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Sequential Organ Failure Assessment (SOFA) Score

Defined as the day 4 post-randomization SOFA score minus the initial SOFA score. The Sequential Organ Failure Assessment (SOFA) Score is a mortality prediction score that is based on the degree of dysfunction of six organ systems. The score is calculated on admission and every 24 hours until discharge using the worst parameters measured during the prior 24 hours SOFA score ranges from 0 (no organ dysfunction) to 24 (highest possible score / organ dysfunction). (NCT03422159)
Timeframe: 4 days post-randomization

Interventionscore on a scale (Mean)
Treatment Arm2.9
Placebo Arm1.93

Hospital Length of Stay

Time from admitting to discharge of hospital stay. (NCT03422159)
Timeframe: From admission to the hospital until final discharge, up to 28 days.

InterventionDays (Mean)
Treatment Arm11.5
Placebo Arm11

Hospital Mortality

In-hospital mortality rate. (NCT03422159)
Timeframe: Survival until hospital discharge, up to 28 days.

InterventionParticipants (Count of Participants)
Treatment Arm11
Placebo Arm13

ICU Length of Stay

Time from admitting to ICU to discharge. (NCT03422159)
Timeframe: From admission to the ICU until final discharge from the ICU, up to an average of 7 days.

Interventiondays (Mean)
Treatment Arm4.76
Placebo Arm4.66

ICU Mortality

ICU mortality rate (NCT03422159)
Timeframe: From admission to hospital until final discharge from the ICU, up to 28 days.

InterventionParticipants (Count of Participants)
Treatment Arm6
Placebo Arm10

Procalcitonin (PCT) Clearance

PCT at 96 hours minus initial PCT, divided by the initial PCT multiplied by 100. (NCT03422159)
Timeframe: 4 days post-randomization

InterventionPercent (Mean)
Treatment Arm63
Placebo Arm58

Time to Vasopressor Independence (Hours)

Defined as the time from starting the active treatment/placebo to discontinuation of all pressors. (NCT03422159)
Timeframe: From start of vasopressor medication to final discontinuation of vasopressor medication, up to 7 days.

Interventionhours (Mean)
HAT Treatment27
Comparator53

Ventilator Free Days

Number of days alive and off of the ventilator at day 28. (NCT03422159)
Timeframe: 28 Days post-randomization

InterventionDays (Mean)
Treatment Arm22
Placebo Arm22.4

Reviews

3 reviews available for thiamine and Electrolytes

ArticleYear
[Refeeding syndrome : Pathophysiology, risk factors, prevention, and treatment].
    Der Internist, 2018, Volume: 59, Issue:4

    Topics: Blood Glucose; Electrolytes; Energy Metabolism; Fasting; Humans; Hunger; Insulin; Magnesium; Malnutr

2018
Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU.
    Critical care medicine, 2016, Volume: 44, Issue:8

    Topics: Alcohol-Induced Disorders; Dietary Supplements; Electrolytes; Folic Acid; Humans; Intensive Care Uni

2016
Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU.
    Critical care medicine, 2016, Volume: 44, Issue:8

    Topics: Alcohol-Induced Disorders; Dietary Supplements; Electrolytes; Folic Acid; Humans; Intensive Care Uni

2016
Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU.
    Critical care medicine, 2016, Volume: 44, Issue:8

    Topics: Alcohol-Induced Disorders; Dietary Supplements; Electrolytes; Folic Acid; Humans; Intensive Care Uni

2016
Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU.
    Critical care medicine, 2016, Volume: 44, Issue:8

    Topics: Alcohol-Induced Disorders; Dietary Supplements; Electrolytes; Folic Acid; Humans; Intensive Care Uni

2016
[Late withdrawal syndrome].
    Ryoikibetsu shokogun shirizu, 2003, Issue:40

    Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Diagnosis, Differential; Electrolytes; Ethanol; Fluid

2003

Trials

2 trials available for thiamine and Electrolytes

ArticleYear
Management of acute metabolic decompensation in maple syrup urine disease: a multi-center study.
    Pediatrics international : official journal of the Japan Pediatric Society, 1999, Volume: 41, Issue:2

    Topics: Acute Disease; Adolescent; Child; Child, Preschool; Electrolytes; Female; Glucose; Health Care Surve

1999
[Possible clinical cure in a high percentage of cases of liver cirrhosis with a treatment based on high doses of testosterone and vitamin B 1 ].
    Minerva medica, 1973, May-02, Volume: 64, Issue:30

    Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Bilirubin; Blood Proteins; Blood Sedimentation; Child

1973

Other Studies

22 other studies available for thiamine and Electrolytes

ArticleYear
Recognizing neonatal refeeding syndrome and thiamin supplementation: A case report.
    JPEN. Journal of parenteral and enteral nutrition, 2023, Volume: 47, Issue:3

    Topics: Adult; Child; Dietary Supplements; Electrolytes; Humans; Infant, Newborn; Refeeding Syndrome; Thiami

2023
Influence of Glucose Dosage in Parenteral Nutrition on Body Thiamine Levels in Rats.
    International journal of medical sciences, 2019, Volume: 16, Issue:1

    Topics: Amino Acids; Animals; Brain; Electrolytes; Glucose; Japan; Liver; Male; Muscle, Skeletal; Organ Spec

2019
Refeeding syndrome is uncommon in alcoholics admitted to a hospital detoxification unit.
    Internal medicine journal, 2014, Volume: 44, Issue:5

    Topics: Adult; Aged; Alcoholism; Blood Chemical Analysis; Diagnostic Tests, Routine; Diet; Electrolytes; Fem

2014
Stability of hydrophilic vitamins mixtures in the presence of electrolytes and trace elements for parenteral nutrition: a nuclear magnetic resonance spectroscopy investigation.
    Journal of pharmaceutical and biomedical analysis, 2015, Mar-25, Volume: 107

    Topics: Drug Stability; Electrolytes; Flavin Mononucleotide; Hydrophobic and Hydrophilic Interactions; Magne

2015
Application of renewable silver amalgam annular band electrode to voltammetric determination of vitamins C, B1 and B2.
    Talanta, 2011, May-30, Volume: 84, Issue:4

    Topics: Alloys; Ascorbic Acid; Beverages; Buffers; Calibration; Electrochemistry; Electrodes; Electrolytes;

2011
[Acute experimental triorthocresylphosphate poisoning. II. Behavior of the electrolytes and vitamin B-1].
    Folia medica. Folia medica (Naples, Italy), 1962, Volume: 45

    Topics: Electrolytes; Organophosphate Poisoning; Phosphorus; Poisons; Thiamine; Vitamins

1962
Electrolyte changes in tissues of chronic thiamine deficient rats and influence of certain steroids.
    The American journal of physiology, 1952, Volume: 169, Issue:3

    Topics: Animals; Electrolytes; Rats; Steroids; Thiamine; Thiamine Deficiency; Vitamin B Deficiency

1952
Lead poisoning and toxicokinetics in a heifer and fetus treated with CaNa2 EDTA and thiamine.
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc, 1995, Volume: 7, Issue:4

    Topics: Animals; Antidotes; Brain; Calcium; Cattle; Cattle Diseases; Copper; Edetic Acid; Electrolytes; Fece

1995
Stability of cocarboxylase in parenteral nutrition mixtures stored in multilayer bags.
    Clinical nutrition (Edinburgh, Scotland), 1998, Volume: 17, Issue:5

    Topics: Amino Acids; Chromatography, High Pressure Liquid; Drug Stability; Electrolytes; Glucose; Humans; Pa

1998
Primary alcoholic heart disease.
    Annals of the New York Academy of Sciences, 1975, Apr-25, Volume: 252

    Topics: Alcoholism; Cardiomegaly; Cell Membrane Permeability; Diagnosis, Differential; Diet Therapy; Digital

1975
[Studies on the state of vitamins B1, B2 and B6 in Down's syndrome].
    Fortschritte der Medizin, 1975, Sep-11, Volume: 93, Issue:25

    Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Down Syndrome; Electrolytes; Female; Human

1975
[Rapid replacement of fluid loss during work at high temperatures].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1978, Jul-01, Volume: 31, Issue:13

    Topics: Ascorbic Acid; Drinking; Electrolytes; Humans; Physical Exertion; Sweating; Temperature; Thiamine; W

1978
Sulfur-induced polioencephalomalacia in sheep: some biochemical changes.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 1989, Volume: 53, Issue:4

    Topics: Animals; Aspartate Aminotransferases; Creatine Kinase; Electrolytes; Encephalomalacia; gamma-Glutamy

1989
[EKG changes in acute pachycarpine poisoning].
    Kardiologiia, 1973, Volume: 13, Issue:4

    Topics: Acute Disease; Adenosine Triphosphate; Adult; Alkaloids; Electrocardiography; Electrolytes; Erythroc

1973
Kinetic salt effect in pharmaceutical investigations.
    Journal of pharmaceutical sciences, 1970, Volume: 59, Issue:8

    Topics: Chemical Phenomena; Chemistry; Chlorpromazine; Echothiophate Iodide; Electrolytes; Ions; Kinetics; M

1970
[Electron-microscopic detection of intracellular electrolytes and its physiological significance (4)].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1969, Volume: 14, Issue:12

    Topics: Animals; Autoradiography; Birds; Chlorine; Electrolytes; Gastric Mucosa; Histocytochemistry; Intesti

1969
Biochemical aspects of an outbreak of bovine polioencephalomalacia.
    The Canadian veterinary journal = La revue veterinaire canadienne, 1970, Volume: 11, Issue:3

    Topics: Animals; Cattle; Cattle Diseases; Electrolytes; Encephalomalacia; Lactates; Pyruvates; Rumen; Thiami

1970
Thiamine deficiency in an Atlantic bottle-nosed dolphin (Tursiops truncatus) on a diet of raw fish.
    Journal of the American Veterinary Medical Association, 1970, Sep-01, Volume: 157, Issue:5

    Topics: Alkaline Phosphatase; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Aspartate Am

1970
Optimal therapy of the alcohol withdrawal state.
    Current psychiatric therapies, 1970, Volume: 10

    Topics: Adult; Chlordiazepoxide; Chlorpromazine; Electrolytes; Female; Humans; Hydroxyzine; Male; Paraldehyd

1970
[Pathology caused by tri-orthocresylphosphate. Experimental research].
    Minerva medica, 1968, Sep-29, Volume: 59, Issue:78

    Topics: Animals; Brain Diseases; Cholinesterases; Cresols; Electroencephalography; Electrolytes; Electromyog

1968
[Clinical study of some metabolic parameters after administration of thiamine in high doses].
    Acta anaesthesiologica, 1968, Volume: 19

    Topics: Acid Phosphatase; Acid-Base Equilibrium; Adult; Alkaline Phosphatase; Carbohydrate Metabolism; Elect

1968
[On some plasma electrolytes during NLA II associated with thiaminic synaptolysis].
    Acta anaesthesiologica, 1968, Volume: 19

    Topics: Adult; Aged; Calcium; Chlorine; Electrolytes; Humans; Middle Aged; Neuroleptanalgesia; Potassium; So

1968