thiamine has been researched along with Drug Withdrawal Symptoms in 35 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe thiamine supplementation incidence in patients with AUD and various critical illnesses (alcohol withdrawal, septic shock, traumatic brain injury [TBI], and diabetic ketoacidosis [DKA]) in the United States." | 8.12 | Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study. ( Balaji, L; Berg, KM; Donnino, MW; Grossestreuer, AV; Holmberg, MJ; Issa, MS; Kronen, R; Moskowitz, A; Patel, PV; Pawar, RD; Thompson, G, 2022) |
| "We found no cases of Wernicke Encephalopathy (WE) and only one case of thiamine deficiency." | 4.31 | Further evidence of relationship between thiamine blood level and cognition in chronic alcohol-dependent adults: Prospective Pilot Study of an inpatient detoxification with oral supplementation protocol. ( Bonnet, U; Claus, BB; McAnally, H; Pohlmann, L, 2023) |
| "To describe thiamine supplementation incidence in patients with AUD and various critical illnesses (alcohol withdrawal, septic shock, traumatic brain injury [TBI], and diabetic ketoacidosis [DKA]) in the United States." | 4.12 | Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study. ( Balaji, L; Berg, KM; Donnino, MW; Grossestreuer, AV; Holmberg, MJ; Issa, MS; Kronen, R; Moskowitz, A; Patel, PV; Pawar, RD; Thompson, G, 2022) |
| " It was not associated with gross liver disease, phenothiazine administration, or familial chorea, and no consistent abnormalities in whole blood thiamine or nicotinic acid, in serum magnesium, or in serum vitamin B(12) levels were present." | 3.65 | Choreoathetotic movement disorder in alcoholism. ( Bolt, JM; Kershaw, PW; Mullin, PJ, 1970) |
| "Thiamine was found to significantly improve recognition accuracy and P300 amplitude, at the midline parietal (Pz) electrode." | 2.68 | Beneficial effects of thiamine on recognition memory and P300 in abstinent cocaine-dependent patients. ( Bauer, LO; Easton, CJ, 1997) |
| " Dosage should be individualized, based on withdrawal severity measured by withdrawal scales, comorbid illness, and history of withdrawal seizures." | 2.40 | Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. ( Mayo-Smith, MF, 1997) |
| "The role of alcohol abuse is common in the onset of cancer of the upper aerodigestive tract, especially that affecting the tongue, floor of the mouth, palatine tonsil and piriform sinus." | 1.56 | Prevention of withdrawal symptoms in alcoholic patients with head and neck cancer. ( Crescenzi, D; Croce, A; Laus, M; Radici, M; Trignani, M, 2020) |
| "The magnesium deficiency is discussed for longstanding malnutrition in both groups, the vitamin B-1 deficiency for an unusual high intake of alcohol before delirium tremens started." | 1.26 | The significance of the serum levels of vitamin B-1 and magnesium in delirium tremens and alcoholism. ( Hoes, MJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (45.71) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 6 (17.14) | 24.3611 |
| 2020's | 5 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Pawar, RD | 1 |
| Balaji, L | 1 |
| Grossestreuer, AV | 1 |
| Thompson, G | 1 |
| Holmberg, MJ | 1 |
| Issa, MS | 1 |
| Patel, PV | 1 |
| Kronen, R | 1 |
| Berg, KM | 1 |
| Moskowitz, A | 1 |
| Donnino, MW | 1 |
| Ganatra, RB | 1 |
| Breu, AC | 1 |
| Ronan, MV | 1 |
| Bonnet, U | 1 |
| Pohlmann, L | 1 |
| McAnally, H | 1 |
| Claus, BB | 1 |
| Maguire, D | 1 |
| Talwar, D | 1 |
| Burns, A | 1 |
| Catchpole, A | 1 |
| Stefanowicz, F | 1 |
| Robson, G | 1 |
| Ross, DP | 1 |
| Young, D | 1 |
| Ireland, A | 1 |
| Forrest, E | 1 |
| Galloway, P | 1 |
| Adamson, M | 1 |
| Colgan, E | 1 |
| Bell, H | 1 |
| Orr, L | 1 |
| Kerr, JL | 1 |
| Roussis, X | 1 |
| McMillan, DC | 1 |
| McLean, C | 1 |
| Tapsell, L | 1 |
| Grafenauer, S | 1 |
| McMahon, AT | 1 |
| Laus, M | 1 |
| Trignani, M | 1 |
| Crescenzi, D | 1 |
| Radici, M | 1 |
| Croce, A | 1 |
| Längle, G | 1 |
| Pollmächer, T | 1 |
| Cresce, ND | 1 |
| McManus, KA | 1 |
| Sifri, CD | 1 |
| Wilson, BB | 1 |
| Zahr, NM | 2 |
| Mayer, D | 1 |
| Vinco, S | 1 |
| Orduna, J | 1 |
| Luong, R | 2 |
| Sullivan, EV | 2 |
| Pfefferbaum, A | 2 |
| Ward, D | 1 |
| Murch, N | 1 |
| Agarwal, G | 1 |
| Bell, D | 1 |
| Damsgaard, L | 1 |
| Ulrichsen, J | 1 |
| Nielsen, MK | 1 |
| Alvarado, MX | 1 |
| Rodriguez Morera, J | 1 |
| Martin Fernandez, X | 1 |
| Juanós Iborra, M | 1 |
| Okudaira, K | 1 |
| Emerton, T | 1 |
| Holloway, HC | 1 |
| Hales, RE | 1 |
| Watanabe, HK | 1 |
| Everett, G | 1 |
| Hughes, JR | 1 |
| Higgins, ST | 1 |
| Bickel, WK | 1 |
| Hayashida, M | 1 |
| Easton, CJ | 1 |
| Bauer, LO | 1 |
| Mayo-Smith, MF | 1 |
| Talbott, GD | 1 |
| Hoes, MJ | 1 |
| Robertson, CC | 1 |
| Sellers, EM | 1 |
| Mileĭkovskiĭ, IuA | 1 |
| Vischer, A | 1 |
| Hell, D | 1 |
| Kaim, SC | 4 |
| Mullin, PJ | 1 |
| Kershaw, PW | 1 |
| Bolt, JM | 1 |
| Houillon, G | 1 |
| Samulak, G | 1 |
| Houillon, P | 1 |
| Rothstein, E | 1 |
| Kreisberg, RA | 1 |
| Sapira, JD | 1 |
| Klett, CJ | 2 |
| Rothfeld, B | 1 |
| Hollister, LE | 1 |
| Caffey, EM | 1 |
| Jancy, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acamprosate for Central Nervous System Hyperexcitability and Neuroadaptation in Alcohol Withdrawal[NCT00106106] | Phase 2 | 56 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The ratio of glutamate to creatine was determined using magnetic resonance spectroscopy (MRS), a technique that complements magnetic resonance imaging (MRI). MRS is used to determine the concentration of brain metabolites, such as glutamate, in brain tissue. MRS utilizes a magnetic field to look at magnetic nuclei, which absorb and re-emit electromagnetic energy in the presence of the magnetic field. By looking at the peaks in the resultant spectra the structure and concentration of metabolites can be determined. (NCT00106106)
Timeframe: Day 25
| Intervention | Ratio of glutamate to creatine (Mean) |
|---|---|
| Placebo | 1.350375 |
| Acamprosate | 1.166667 |
The ratio of glutamate to creatine was determined using magnetic resonance spectroscopy (MRS), a technique that complements magnetic resonance imaging (MRI). MRS is used to determine the concentration of brain metabolites, such as glutamate, in brain tissue. MRS utilizes a magnetic field to look at magnetic nuclei, which absorb and re-emit electromagnetic energy in the presence of the magnetic field. By looking at the peaks in the resultant spectra the structure and concentration of metabolites can be determined. (NCT00106106)
Timeframe: Day 4
| Intervention | Ratio of glutamate to creatine (Mean) |
|---|---|
| Placebo | 1.256772 |
| Acamprosate | 1.294178 |
4 reviews available for thiamine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
[Late withdrawal syndrome].
Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Diagnosis, Differential; Electrolytes; Ethanol; Fluid | 2003 |
Common errors in the pharmacologic treatment of drug dependence and withdrawal.
Topics: Behavior Therapy; Buprenorphine; Clonidine; Humans; Lithium; Methadone; Narcotics; Nicotine; Psychot | 1994 |
[Inpatient treatment of alcohol dependence].
Topics: Alcohol Deterrents; Alcoholism; Anti-Anxiety Agents; Benzodiazepines; Disulfiram; Ethanol; Hospitali | 1997 |
Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal.
Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Antipsychotic Agents; Benzodiazepines; Car | 1997 |
4 trials available for thiamine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Beneficial effects of thiamine on recognition memory and P300 in abstinent cocaine-dependent patients.
Topics: Adult; Attention; Cerebral Cortex; Cocaine; Double-Blind Method; Electroencephalography; Event-Relat | 1997 |
Prevention of delirium tremens: use of phenothiazines versus drugs cross-dependent with alcohol.
Topics: Antipsychotic Agents; Biogenic Amines; Brain Chemistry; Chlordiazepoxide; Chlorpromazine; Drug Toler | 1974 |
Treatment of the acute alcohol withdrawal state: a comparison of four drugs.
Topics: Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Humans; Hydroxyzine; Middle Aged; Placeb | 1969 |
Evaluating changes in symptoms during acute alcohol withdrawal.
Topics: Affect; Alcoholism; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Female; Humans; Hydr | 1971 |
27 other studies available for thiamine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study.
Topics: Adult; Alcoholism; Critical Illness; Dietary Supplements; Humans; Male; Middle Aged; Retrospective S | 2022 |
Which patients hospitalized with alcohol withdrawal syndrome should receive high-dose parenteral thiamine?
Topics: Alcoholism; Humans; Substance Withdrawal Syndrome; Thiamine; Thiamine Deficiency | 2023 |
Further evidence of relationship between thiamine blood level and cognition in chronic alcohol-dependent adults: Prospective Pilot Study of an inpatient detoxification with oral supplementation protocol.
Topics: Adult; Alcoholism; Cognition; Dietary Supplements; Female; Humans; Inpatients; Male; Middle Aged; Pi | 2023 |
A prospective evaluation of thiamine and magnesium status in relation to clinicopathological characteristics and 1-year mortality in patients with alcohol withdrawal syndrome.
Topics: Adult; Alcoholism; Female; Humans; Magnesium; Male; Middle Aged; Prospective Studies; Substance With | 2019 |
Nutritional Care of Patients Admitted to Hospital for Alcohol Withdrawal: A 5-Year Retrospective Audit.
Topics: Adult; Aged; Alcohol Abstinence; Ethanol; Female; Humans; Length of Stay; Male; Middle Aged; Nutriti | 2020 |
Prevention of withdrawal symptoms in alcoholic patients with head and neck cancer.
Topics: Alcoholism; Antipsychotic Agents; Cancer Care Facilities; Cultural Characteristics; Head and Neck Ne | 2020 |
[Reports from the Federal Conference of German Psychiatry and Psychotherapy Clinics].
Topics: Alcoholism; Ambulatory Care; Caregivers; Combined Modality Therapy; Ethanol; Germany; Hospitals, Psy | 2013 |
Encephalopathy despite thiamine repletion during alcohol withdrawal.
Topics: Alcoholism; Humans; Male; Middle Aged; Niacin; Pellagra; Substance Withdrawal Syndrome; Thiamine; Th | 2014 |
In vivo evidence for alcohol-induced neurochemical changes in rat brain without protracted withdrawal, pronounced thiamine deficiency, or severe liver damage.
Topics: Animals; Basal Ganglia; Choline; Ethanol; Fatty Liver; Glutamic Acid; Glutamine; Glycogen Storage Di | 2009 |
A multi-centre survey of inpatient pharmacological management strategies for alcohol withdrawal.
Topics: Alcoholism; Guideline Adherence; Health Care Surveys; Hospitalization; Humans; Hypnotics and Sedativ | 2009 |
[Wernicke's encephalopathy in patients with alcohol withdrawal symptoms].
Topics: Adult; Ethanol; Female; Humans; Male; Middle Aged; Prospective Studies; Substance Withdrawal Syndrom | 2010 |
Measurement of serum, liver, and brain cytokine induction, thiamine levels, and hepatopathology in rats exposed to a 4-day alcohol binge protocol.
Topics: Alcoholism; Alkaline Phosphatase; Animals; Behavior, Animal; Body Weight; Brain Chemistry; Chemical | 2010 |
[Lactic acidosis due to thiamine deficiency].
Topics: Acidosis, Lactic; Anorexia; Asthenia; Buprenorphine; Cachexia; Humans; Male; Methadone; Middle Aged; | 2012 |
AOD expertise.
Topics: Alcohol-Induced Disorders; Buprenorphine; Humans; Infusions, Parenteral; Narcotic Antagonists; Narco | 2005 |
Recognition and treatment of acute alcohol withdrawal syndromes.
Topics: Acute Disease; Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Chloral Hydrate; Ethanol; F | 1984 |
Alcohol withdrawal syndrome: prevention and treatment.
Topics: Administration, Oral; Alcohol Drinking; Alcohol Withdrawal Delirium; Benzodiazepines; Ethanol; Human | 1981 |
Primary alcoholic heart disease.
Topics: Alcoholism; Cardiomegaly; Cell Membrane Permeability; Diagnosis, Differential; Diet Therapy; Digital | 1975 |
The significance of the serum levels of vitamin B-1 and magnesium in delirium tremens and alcoholism.
Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Humans; Magnesium; Magnesium Deficiency; Middl | 1979 |
Alcohol intoxication and the alcohol withdrawal syndrome.
Topics: Alcoholic Intoxication; Alcoholism; Benzodiazepines; Chlordiazepoxide; Hallucinations; Humans; Pheny | 1978 |
[Thiamine deficit in acute alcoholic psychoses].
Topics: Acute Disease; Citrates; Erythrocytes; Female; Humans; Male; Psychoses, Alcoholic; Pyruvates; Sex Fa | 1976 |
[Cognitive deficits, vitamin status and controlled thiamine substitution in alcohol dependent patients in withdrawal treatment].
Topics: Adult; Alcoholism; Cognition Disorders; Ethanol; Follow-Up Studies; Humans; Male; Middle Aged; Neuro | 1989 |
Choreoathetotic movement disorder in alcoholism.
Topics: Adult; Aged; Alcoholism; Athetosis; Chorea; Female; Humans; Huntington Disease; Liver Diseases; Magn | 1970 |
[Apropos of a case of Gayet-Wernicke's encephalopathy in a latent epileptic. Centrophenoxine and thiamine. Electro-clinical contraindications].
Topics: Acetates; Adult; Central Nervous System Stimulants; Epilepsy, Tonic-Clonic; Humans; Hydroxocobalamin | 1968 |
Prevention of alcohol withdrawal seizures: the roles of diphenylhydantoin and chlordiazepoxide.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; Neurons; Phe | 1973 |
Medical grand rounds from the University of Alabama Medical Center. Alcoholism.
Topics: Alcohol Amnestic Disorder; Alcohol Oxidoreductases; Alcoholism; Barbiturates; Drug Interactions; Eth | 1973 |
Lack of sobering effect of fructose-vitamin tablets.
Topics: Alcohol Drinking; Caffeine; Chlorophyll; Ethanol; Fructose; Humans; Pyridoxine; Substance Withdrawal | 1970 |
Optimal therapy of the alcohol withdrawal state.
Topics: Adult; Chlordiazepoxide; Chlorpromazine; Electrolytes; Female; Humans; Hydroxyzine; Male; Paraldehyd | 1970 |