thiamine has been researched along with Down Syndrome in 4 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirdly, the peculiar pathology of trisomy 21 allows to find also a cholinergic disturbance and a disturbance close to the 10 formyl-tetrahydrololate entry of the folate cycle." | 1.26 | [Biochemical investigations and trisomy 21 (author's transl)]. ( Lejeune, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reading, CM | 1 |
| Matin, MA | 1 |
| Sylvester, PE | 1 |
| Edwards, D | 1 |
| Dickerson, JW | 1 |
| Schmid, F | 1 |
| Christeller, S | 1 |
| Rehm, W | 1 |
| Lejeune, J | 1 |
1 review available for thiamine and Down Syndrome
| Article | Year |
|---|---|
Down's syndrome: nutritional intervention.
Topics: Adolescent; Adult; Autoimmune Diseases; Blood Glucose; Child; Child, Preschool; Chromatin; Down Synd | 1984 |
3 other studies available for thiamine and Down Syndrome
| Article | Year |
|---|---|
Vitamin and zinc status in Down syndrome.
Topics: Adult; Ascorbic Acid; Down Syndrome; Female; Humans; Middle Aged; Nicotinic Acids; Skin Diseases; Th | 1981 |
[Studies on the state of vitamins B1, B2 and B6 in Down's syndrome].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Child; Down Syndrome; Electrolytes; Female; Human | 1975 |
[Biochemical investigations and trisomy 21 (author's transl)].
Topics: Down Syndrome; Folic Acid; Glyoxylates; Humans; Hydrogen Peroxide; Intellectual Disability; Oxalates | 1979 |