thiamine and Disease Models, Animal studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

Excerpt	Relevance	Reference
"At present, thiamine deficiency (TD) is managed with administration of high doses of thiamine."	8.02	Thiamine deficiency and recovery: impact of recurrent episodes and beneficial effect of treatment with Trolox and dimethyl sulfoxide. ( da Silva Aguiar, HQ; de Araújo, SS; de Cordova, CAS; de Cordova, FM; Gomes, KC; Lima, FWB, 2021)
" The study looked at how the thiamine supplement impacted pentylenetetrazole (PTZ)-induced seizures in rats and pentylenetetrazole-induced neurotoxicity in the SH-SY5Y cell line."	8.02	The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. ( Ergul, M; Taskiran, AS, 2021)
"The effects of chronic EtOH consumption, associated or not with thiamine deficiency (TD), on cognitive impairment, oxidative damage, and β-amyloid (Aβ) peptide accumulation in the brain were investigated in male C57BL/6 mice."	7.85	Comparative effects of EtOH consumption and thiamine deficiency on cognitive impairment, oxidative damage, and β-amyloid peptide overproduction in the brain. ( Gao, YQ; Gong, YS; Guo, J; Hou, FL; Hu, K; Liang, CY; Song, FL; Yang, LQ, 2017)
"The effect of oral thiamine supplementation (2%) on hepatocellular carcinoma induced by Cu(2+) accumulation in the livers of Atp7b animals at 4, 6, 9, 12, 16, and 21 months was demonstrated using gross morphology and multi-nucleate analysis."	7.77	Thiamine supplementation attenuated hepatocellular carcinoma in the Atp7b mouse model of Wilson's disease. ( Sheline, CT, 2011)
"Thiamine deficiency caused death of CGNs but ethanol did not."	7.75	Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase. ( Fan, Z; Ke, ZJ; Luo, J; Wang, X, 2009)
"Wernicke's encephalopathy (WE) is characterized by lesions in thalamus, hypothalamus (including mammillary nuclei), and inferior colliculi, results in serious disabilities, has an etiology of thiamine deficiency, is treatable with thiamine, and occurs most commonly with alcoholism."	7.74	Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study. ( Adalsteinsson, E; Bell, RL; Pfefferbaum, A; Sullivan, EV, 2007)
" A rodent model of Wernicke-Korsakoff Syndrome (WKS), acute pyrithiamine-induced thiamine deficiency (PTD), produces diencephalic damage and impairments of memory similar to what is seen in WKS patients."	7.72	Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult. ( Pitkin, SR; Savage, LM, 2004)
"Neurodegenerative diseases are characterized by abnormalities in oxidative processes, region-selective neuron loss, and diminished thiamine-dependent enzymes."	7.72	Reversal of thiamine deficiency-induced neurodegeneration. ( DeGiorgio, LA; Gibson, GE; Ke, ZJ; Volpe, BT, 2003)
"We produced thiamine deficiency by treating mice with a thiamine deficient (TD) diet, but not with pyrithiamine, a thiamine antagonist."	7.71	Antinociceptive effect following dietary-induced thiamine deficiency in mice: involvement of substance P and somatostatin. ( Arai, Y; Asao, T; Hozumi, S; Kinemuchi, H; Kisara, K; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Taniguchi, R; Yasuhara, H, 2001)
"Rats that had recovered from pyrithiamine-induced thiamine deficiency (PTD) were trained on tasks motivated by escape from mild footshock."	7.68	Analysis of aversively conditioned learning and memory in rats recovered from pyrithiamine-induced thiamine deficiency. ( Knoth, RL; Langlais, PJ; Mair, RG; Otto, TA; Rabchenuk, SA, 1991)
"The [14C]deoxyglucose technique was used to determine local cerebral glucose utilization (LCGU) in the rat at various times in two models of thiamine deficiency: pyrithiamine administration in addition to dietary deprivation, and dietary deprivation alone."	7.66	Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency. ( Hakim, AM; Pappius, HM, 1983)
"Thiamine/biotin treatment of R6/1 HD mice to compensate for TPK1 dysregulation restores OL maturation and rescues neuronal pathology."	5.72	Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation. ( Adam, M; Al-Dalahmah, O; Casaccia, P; Dansu, DK; Davidson, S; Flowers, XE; Fraenkel, E; Gold, MP; Goldman, JE; Hickman, RA; Khan, F; Lau, A; Lim, RG; McClure, N; Menon, V; Michael, N; Miramontes, R; Miyoshi, E; Ofori, K; Park, HJ; Paryani, F; Reidling, JC; Reyes-Ortiz, AM; Swarup, V; Tang, A; Tang, G; Thompson, LM; Vonsattel, JP; Wu, J, 2022)
"Sepsis was induced in female mice using the cecal ligation and puncture (CLP) model."	5.56	Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) Therapy Decreases Oxidative Stress, Improves Cardiovascular Function, and Improves Survival in Murine Sepsis. ( Arnaout, L; Kim, J; Remick, D, 2020)
"Hydrocortisone, ascorbic acid, and thiamine therapy has minimal benefits in pneumonia."	4.12	Machine learning and murine models explain failures of clinical sepsis trials. ( Kim, J; Remick, DG; Rop, K; Stolarski, AE; Wee, K; Zhang, Q, 2022)
"At present, thiamine deficiency (TD) is managed with administration of high doses of thiamine."	4.02	Thiamine deficiency and recovery: impact of recurrent episodes and beneficial effect of treatment with Trolox and dimethyl sulfoxide. ( da Silva Aguiar, HQ; de Araújo, SS; de Cordova, CAS; de Cordova, FM; Gomes, KC; Lima, FWB, 2021)
" The study looked at how the thiamine supplement impacted pentylenetetrazole (PTZ)-induced seizures in rats and pentylenetetrazole-induced neurotoxicity in the SH-SY5Y cell line."	4.02	The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. ( Ergul, M; Taskiran, AS, 2021)
" The present study was designed to investigate the effect of acute and chronic administration of thiamine alone and in combination with sub-effective dose of diazepam on pentylenetetrazole (PTZ)-induced tonic-clonic seizures in mice."	3.91	Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. ( Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A, 2019)
"The effects of chronic EtOH consumption, associated or not with thiamine deficiency (TD), on cognitive impairment, oxidative damage, and β-amyloid (Aβ) peptide accumulation in the brain were investigated in male C57BL/6 mice."	3.85	Comparative effects of EtOH consumption and thiamine deficiency on cognitive impairment, oxidative damage, and β-amyloid peptide overproduction in the brain. ( Gao, YQ; Gong, YS; Guo, J; Hou, FL; Hu, K; Liang, CY; Song, FL; Yang, LQ, 2017)
"The effect of oral thiamine supplementation (2%) on hepatocellular carcinoma induced by Cu(2+) accumulation in the livers of Atp7b animals at 4, 6, 9, 12, 16, and 21 months was demonstrated using gross morphology and multi-nucleate analysis."	3.77	Thiamine supplementation attenuated hepatocellular carcinoma in the Atp7b mouse model of Wilson's disease. ( Sheline, CT, 2011)
"Thiamine deficiency caused death of CGNs but ethanol did not."	3.75	Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase. ( Fan, Z; Ke, ZJ; Luo, J; Wang, X, 2009)
"Wernicke's encephalopathy (WE) is characterized by lesions in thalamus, hypothalamus (including mammillary nuclei), and inferior colliculi, results in serious disabilities, has an etiology of thiamine deficiency, is treatable with thiamine, and occurs most commonly with alcoholism."	3.74	Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study. ( Adalsteinsson, E; Bell, RL; Pfefferbaum, A; Sullivan, EV, 2007)
" Since dietary thiamine deficiency (TD) in mice is considered as a putative model of WKS, it was used in the present study to investigate the function of serotonergic neurons in this disorder."	3.74	Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice. ( Arai, Y; Mitazaki, S; Murata, A; Nakagawasai, O; Niijima, F; Ohba, A; Tadano, T; Tan-No, K; Wakui, K, 2007)
"Long-term thiamine deficiency has been largely documented, whilst little is known about effects of short-term depletion/repletion periods on thiamine vitamers status."	3.74	Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model. ( Batifoulier, F; Besson, C; Chanliaud, E; Demigné, C; Rémésy, C; Verny, MA, 2007)
"Neurodegenerative diseases are characterized by abnormalities in oxidative processes, region-selective neuron loss, and diminished thiamine-dependent enzymes."	3.72	Reversal of thiamine deficiency-induced neurodegeneration. ( DeGiorgio, LA; Gibson, GE; Ke, ZJ; Volpe, BT, 2003)
" A rodent model of Wernicke-Korsakoff Syndrome (WKS), acute pyrithiamine-induced thiamine deficiency (PTD), produces diencephalic damage and impairments of memory similar to what is seen in WKS patients."	3.72	Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult. ( Pitkin, SR; Savage, LM, 2004)
"We produced thiamine deficiency by treating mice with a thiamine deficient (TD) diet, but not with pyrithiamine, a thiamine antagonist."	3.71	Antinociceptive effect following dietary-induced thiamine deficiency in mice: involvement of substance P and somatostatin. ( Arai, Y; Asao, T; Hozumi, S; Kinemuchi, H; Kisara, K; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Taniguchi, R; Yasuhara, H, 2001)
"Rats that had recovered from pyrithiamine-induced thiamine deficiency (PTD) were trained on tasks motivated by escape from mild footshock."	3.68	Analysis of aversively conditioned learning and memory in rats recovered from pyrithiamine-induced thiamine deficiency. ( Knoth, RL; Langlais, PJ; Mair, RG; Otto, TA; Rabchenuk, SA, 1991)
"The [14C]deoxyglucose technique was used to determine local cerebral glucose utilization (LCGU) in the rat at various times in two models of thiamine deficiency: pyrithiamine administration in addition to dietary deprivation, and dietary deprivation alone."	3.66	Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency. ( Hakim, AM; Pappius, HM, 1983)
"Neuroinflammation is caused due to the activation of microglia along with pro-inflammatory cytokines."	1.91	Neuroprotective effects of vitamin B1 on memory impairment and suppression of pro-inflammatory cytokines in traumatic brain injury. ( Ali, Y; Amin, Z; Husn, M; Kanwal, L; Sabir, K; Shah, SA; Shah, SF, 2023)
"The neurodegeneration of Alzheimer's disease (AD) affects not only brain structures associate with cognition early in the progression of the disease, but other areas such as the hypothalamus, a region involved in the control of metabolism and appetite."	1.72	Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in rats. ( Cardinali, CAEF; Donato, J; Gonçalves, AC; Guerra-Shinohara, EM; Kleinridders, A; Leboucher, A; Lima, GCA; Moraes, RCM; Portari, GV; Torrão, ADS, 2022)
"Thiamine/biotin treatment of R6/1 HD mice to compensate for TPK1 dysregulation restores OL maturation and rescues neuronal pathology."	1.72	Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation. ( Adam, M; Al-Dalahmah, O; Casaccia, P; Dansu, DK; Davidson, S; Flowers, XE; Fraenkel, E; Gold, MP; Goldman, JE; Hickman, RA; Khan, F; Lau, A; Lim, RG; McClure, N; Menon, V; Michael, N; Miramontes, R; Miyoshi, E; Ofori, K; Park, HJ; Paryani, F; Reidling, JC; Reyes-Ortiz, AM; Swarup, V; Tang, A; Tang, G; Thompson, LM; Vonsattel, JP; Wu, J, 2022)
"On the 15th day, the seizure was induced (except the control group) by intraperitoneal injection of PTZ."	1.62	Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress. ( Dehdashtian, E; Fatemi, I; Hemati, K; Hosseinzadeh, A; Karimi, MY; Mehrzadi, S, 2021)
"Sepsis was induced in female mice using the cecal ligation and puncture (CLP) model."	1.56	Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) Therapy Decreases Oxidative Stress, Improves Cardiovascular Function, and Improves Survival in Murine Sepsis. ( Arnaout, L; Kim, J; Remick, D, 2020)
"The major adverse effect associated with systemic administration of Fluconazole (FLZ), is hepatic toxicity."	1.51	Vitamin B combination reduces fluconazole toxicity in Wistar rats. ( Al-Abbasi, FA; Anwar, F; Mushtaq, G; Sadath, S, 2019)
" The present data suggest that thiamine precursors with high bioavailability might be useful as a complementary therapy in several neuropsychiatric disorders."	1.46	Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. ( Anthony, DC; Bazhenova, N; Bettendorff, L; Caron, N; Coumans, B; Gorlova, A; Lakaye, B; Malgrange, B; Markova, N; Pavlov, D; Sambon, M; Shevtsova, E; Strekalova, T; Svistunov, A; Vignisse, J; Wins, P, 2017)
"Human study: Post-cardiac arrest patients had lower PDH activity in mononuclear cells than did healthy volunteers (estimated difference: -5."	1.43	Thiamine as a neuroprotective agent after cardiac arrest. ( Andersen, LW; Bagchi, A; Berg, KM; Cocchi, MN; Donnino, MW; Hirai, S; Ichinose, F; Ikeda, K; Kida, K; Liu, X; Marutani, E; Sakaguchi, M, 2016)
"Sepsis was induced by cecal ligation and puncture with the cecum ligated below the cecal valve at 25%, 50%, and 75% of cecal length, defined as severe, moderate, and mild sepsis, respectively."	1.43	Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. ( Fang, L; Said, HM; Sassoon, CS; Subramanian, VS; Zhu, E, 2016)
" On the 20th day after the start of TD feeding, the increased duration of immobility time induced by TD was shortened by chronic administration of the tricyclic antidepressant imipramine (10 mg/kg, i."	1.31	Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice. ( Esashi, A; Hozumi, S; Kisara, K; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Taniguchi, R, 2001)
"Because several previous authors have repeatedly described treatment with thiamine as one of the sufficient prophylactic measures in slowing the development of viscerocranial malformations, especially cleft alveolus and palate, it is of utmost importance that the timing of treatment and dosage of thiamine be taken into consideration not only in animal experiments but also when applying results to humans."	1.30	Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats. ( Bienengräber, V; Fanghänel, J; Kundt, G; Malek, FA, 1997)
"Thiamine treatment of symptomatic rats led to reversal of neurological signs and to concomitant reductions of the cerebral PDHC abnormalities."	1.27	Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy: 1. The pyruvate dehydrogenase complex. ( Besnard, AM; Butterworth, RF; Giguere, JF, 1985)

Research

Studies (76)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Safety and Tolerability of RJX as Assessed by Electrocardiograms (ECGs).

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (18.42)	18.7374
1990's	3 (3.95)	18.2507
2000's	13 (17.11)	29.6817
2010's	31 (40.79)	24.3611
2020's	15 (19.74)	2.80

Authors	Studies
Gomes, KC	1
Lima, FWB	1
da Silva Aguiar, HQ	1
de Araújo, SS	1
de Cordova, CAS	1
de Cordova, FM	1
Yako, H	1
Niimi, N	1
Kato, A	1
Takaku, S	1
Tatsumi, Y	1
Nishito, Y	1
Kato, K	1
Sango, K	1
Zheng, Y	1
Chen, ZY	1
Ma, WJ	1
Wang, QZ	1
Liang, H	1
Ma, AG	1
Stolarski, AE	1
Kim, J	2
Rop, K	1
Wee, K	1
Zhang, Q	2
Remick, DG	1
Moraes, RCM	1
Lima, GCA	1
Cardinali, CAEF	1
Gonçalves, AC	1
Portari, GV	2
Guerra-Shinohara, EM	1
Leboucher, A	1
Donato, J	1
Kleinridders, A	1
Torrão, ADS	1
Uckun, FM	1
Saeed, M	1
Awili, M	1
Ozercan, IH	1
Qazi, S	1
Lee, C	1
Shibli, A	1
Skolnick, AW	1
Prusmack, A	1
Varon, J	1
Barrera, CI	1
Orhan, C	1
Volk, M	1
Sahin, K	1
Vitali, R	1
Prioreschi, C	1
Lorenzo Rebenaque, L	1
Colantoni, E	1
Giovannini, D	1
Frusciante, S	1
Diretto, G	1
Marco-Jiménez, F	1
Mancuso, M	1
Casciati, A	1
Pazzaglia, S	1
Lim, RG	1
Al-Dalahmah, O	1
Wu, J	1
Gold, MP	1
Reidling, JC	1
Tang, G	1
Adam, M	1
Dansu, DK	1
Park, HJ	1
Casaccia, P	1
Miramontes, R	1
Reyes-Ortiz, AM	1
Lau, A	1
Hickman, RA	1
Khan, F	1
Paryani, F	1
Tang, A	1
Ofori, K	1
Miyoshi, E	1
Michael, N	1
McClure, N	1
Flowers, XE	1
Vonsattel, JP	1
Davidson, S	1
Menon, V	1
Swarup, V	1
Fraenkel, E	1
Goldman, JE	1
Thompson, LM	1
Husn, M	1
Amin, Z	1
Ali, Y	1
Kanwal, L	1
Sabir, K	1
Shah, SA	1
Shah, SF	1
Li, EY	1
Zhao, PJ	1
Jian, J	1
Yin, BQ	1
Sun, ZY	1
Xu, CX	1
Tang, YC	1
Wu, H	1
Lewis, MJ	1
Ahmed, LA	1
Hassan, OF	1
Galal, O	1
Mansour, DF	1
El-Khatib, A	1
Taskiran, AS	1
Ergul, M	1
Dehdashtian, E	1
Hosseinzadeh, A	1
Hemati, K	1
Karimi, MY	1
Fatemi, I	1
Mehrzadi, S	1
Gong, YS	1
Hu, K	1
Yang, LQ	1
Guo, J	1
Gao, YQ	1
Song, FL	1
Hou, FL	1
Liang, CY	1
Vignisse, J	3
Sambon, M	1
Gorlova, A	1
Pavlov, D	2
Caron, N	1
Malgrange, B	1
Shevtsova, E	1
Svistunov, A	3
Anthony, DC	2
Markova, N	3
Bazhenova, N	2
Coumans, B	1
Lakaye, B	1
Wins, P	1
Strekalova, T	3
Bettendorff, L	4
Mesdaghinia, A	1
Alinejad, M	1
Abed, A	1
Heydari, A	1
Banafshe, HR	1
Chekhonin, V	1
Pomytkin, I	1
Lioudyno, V	1
Ponomarev, E	1
Lesch, KP	2
Abdel-Haleem, AM	1
Hefzi, H	1
Mineta, K	1
Gao, X	1
Gojobori, T	1
Palsson, BO	1
Lewis, NE	1
Jamshidi, N	1
Onk, D	1
Mammadov, R	1
Suleyman, B	1
Cimen, FK	1
Cankaya, M	1
Gul, V	1
Altuner, D	1
Senol, O	1
Kadioglu, Y	1
Malkoc, I	1
Suleyman, H	2
Sang, S	1
Pan, X	1
Chen, Z	1
Zeng, F	1
Pan, S	1
Liu, H	1
Jin, L	1
Fei, G	1
Wang, C	1
Ren, S	1
Jiao, F	1
Bao, W	1
Zhou, W	1
Guan, Y	1
Zhang, Y	1
Shi, H	1
Wang, Y	3
Yu, X	1
Zhong, C	1
Liu, J	1
Gao, W	1
Pu, L	1
Wei, J	1
Xin, Z	1
Shi, T	1
Guo, C	1
Evans, E	1
Piccio, L	1
Cross, AH	1
Tapias, V	1
Jainuddin, S	1
Ahuja, M	1
Stack, C	1
Elipenahli, C	1
Gerges, M	1
Starkova, N	1
Xu, H	1
Starkov, AA	1
Hushpulian, DM	1
Smirnova, NA	1
Gazaryan, IG	1
Kaidery, NA	1
Wakade, S	1
Calingasan, NY	1
Thomas, B	1
Gibson, GE	2
Dumont, M	1
Beal, MF	1
Scheller, K	3
Quitzke, V	1
Kappler, M	1
Al-Abbasi, FA	1
Sadath, S	1
Mushtaq, G	1
Anwar, F	1
Arnaout, L	1
Remick, D	1
Radonjic, T	1
Rankovic, M	1
Ravic, M	1
Zivkovic, V	1
Srejovic, I	1
Jeremic, J	1
Jeremic, N	1
Sretenovic, J	1
Matic, S	1
Jakovljevic, V	1
Nikolic Turnic, T	1
Röckl, T	1
Scheller, C	1
Schubert, J	2
Hamada, S	1
Hirashima, H	1
Imaeda, M	1
Okamoto, Y	1
Hamaguchi-Hamada, K	1
Kurumata-Shigeto, M	1
Turan, MI	1
Tan, H	1
Cetin, N	1
Cayir, A	1
Zahr, NM	1
Alt, C	1
Mayer, D	1
Rohlfing, T	1
Manning-Bog, A	1
Luong, R	1
Sullivan, EV	2
Pfefferbaum, A	2
Mouton-Liger, F	1
Rebillat, AS	1
Gourmaud, S	1
Paquet, C	1
Leguen, A	1
Dumurgier, J	1
Bernadelli, P	1
Taupin, V	1
Pradier, L	1
Rooney, T	1
Hugon, J	1
E Dief, A	1
M Samy, D	1
I Dowedar, F	1
Kalmring, F	1
Sassoon, CS	1
Zhu, E	1
Fang, L	1
Subramanian, VS	1
Said, HM	1
Ikeda, K	1
Liu, X	1
Kida, K	1
Marutani, E	1
Hirai, S	1
Sakaguchi, M	1
Andersen, LW	1
Bagchi, A	1
Cocchi, MN	1
Berg, KM	1
Ichinose, F	1
Donnino, MW	1
Liu, L	1
Ma, SH	1
Xia, LJ	1
Ovidio, PP	1
Deminice, R	1
Jordão, AA	1
Hazell, AS	1
Afadlal, S	1
Cheresh, DA	1
Azar, A	1
Yang, G	1
Li, W	1
Fan, Z	2
Sun, A	1
Luo, J	2
Ke, ZJ	3
Wang, X	1
Katare, RG	1
Caporali, A	1
Oikawa, A	1
Meloni, M	1
Emanueli, C	1
Madeddu, P	1
Karachalias, N	1
Babaei-Jadidi, R	1
Rabbani, N	1
Thornalley, PJ	1
Sheline, CT	1
Nikseresht, S	1
Etebary, S	1
Karimian, M	1
Nabavizadeh, F	1
Zarrindast, MR	1
Sadeghipour, HR	1
DeGiorgio, LA	1
Volpe, BT	1
Pitkin, SR	1
Savage, LM	1
Wu, S	1
Ren, J	1
Adalsteinsson, E	1
Bell, RL	1
Nakagawasai, O	3
Murata, A	1
Arai, Y	2
Ohba, A	1
Wakui, K	1
Mitazaki, S	1
Niijima, F	3
Tan-No, K	3
Tadano, T	3
Balk, E	1
Chung, M	1
Raman, G	1
Tatsioni, A	1
Chew, P	1
Ip, S	1
DeVine, D	1
Lau, J	1
Batifoulier, F	1
Verny, MA	1
Besson, C	1
Chanliaud, E	1
Rémésy, C	1
Demigné, C	1
Rajaraman, G	1
Wang, G	1
Smith, HJ	1
Gong, Y	1
Burczynski, FJ	1
Petrovic, MM	1
Scepanovic, L	1
Rosic, G	1
Mitrovic, DM	1
Yonekawa, M	1
Kanaya, T	1
Sera, H	1
Sarai, K	1
Aikawa, H	1
Watanabe, IS	1
Furuse, T	1
Iwasaki, Y	1
Satoyoshi, E	1
Sumi, T	1
Moroji, T	1
Hakim, AM	1
Pappius, HM	1
Chan, AW	1
Schanley, DL	1
Leong, FW	1
Gunnison, AF	1
Dulak, L	1
Chiang, G	1
Zaccardi, J	1
Farruggella, TJ	1
Shah, RM	1
Izadnegahdar, MF	1
Hehn, BM	1
Young, AV	1
Bienengräber, V	1
Fanghänel, J	1
Malek, FA	1
Kundt, G	1
Hozumi, S	2
Taniguchi, R	2
Asao, T	1
Kinemuchi, H	1
Yasuhara, H	1
Kisara, K	2
Esashi, A	1
França, DS	1
Souza, AL	1
Almeida, KR	1
Dolabella, SS	1
Martinelli, C	1
Coelho, MM	1
Mair, RG	1
Otto, TA	1
Knoth, RL	1
Rabchenuk, SA	1
Langlais, PJ	1
Pokotilenko, GM	1
Poliachenko, LIu	1
Zenk, W	1
Wagner, T	1
Möckel, M	1
Butterworth, RF	3
Giguère, JF	2
Besnard, AM	2
Miyoshi, T	1
Goto, I	1
Manocha, SL	1
Olkowski, ZL	1
Börcsök, E	1
Földi, K	1
Wittlinger, G	1
Földi, M	1
Heggtveit, HA	1
Grice, HC	1
Wiberg, GS	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Phase 1, Double-blind, Placebo-controlled, Randomized, Two-Part, Ascending Dose-escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Rejuveinix (RJX) in Healthy Participants[NCT03680105]	Phase 1	76 participants (Actual)	Interventional	2018-08-24	Completed
Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.[NCT04284059]	Phase 4	504 participants (Anticipated)	Interventional	2021-02-25	Recruiting
Effect of Combined Vitamin C, Stress-dose Steroids, and Thiamine on Cerebral Autoregulation and Functional Outcomes of Patients With Septic Shock[NCT03649633]	Phase 1/Phase 2	100 participants (Anticipated)	Interventional	2018-09-06	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of participants with abnormal and clinically significant findings based on ECG. (NCT03680105)
Timeframe: Up to Day 2 for Part 1 and Up to Day 8 for Part 2

Safety and Tolerability of RJX as Assessed by Neurological Examinations.

Intervention	Participants (Count of Participants)
Part 1; Placebo	0
Part 1; Cohort 1; RJX	0
Part 1; Cohort 2; RJX	0
Part 1; Cohort 3; RJX	0
Part 1; Cohort 4; RJX	0
Part 1; Cohort 5; RJX	0
Part 1; Cohort 6; RJX	0
Part 2; Placebo	0
Part 2; Cohort 1; RJX	0
Part 2; Cohort 2; RJX	0
Part 2; Cohort 3; RJX	0

Number of participants with clinically significant values and actual changes from baseline of continuous neurological assessments. (NCT03680105)
Timeframe: Up to Day 5 for Part 1 and Up to Day 12 for Part 2

Treatment-related Adverse Events (TEAE) Reporting of RJX

Intervention	Participants (Count of Participants)
Part 1; Placebo	0
Part 1; Cohort 1; RJX	0
Part 1; Cohort 2; RJX	0
Part 1; Cohort 3; RJX	0
Part 1; Cohort 4; RJX	0
Part 1; Cohort 5; RJX	0
Part 1; Cohort 6; RJX	0
Part 2; Placebo	0
Part 2; Cohort 1; RJX	0
Part 2; Cohort 2; RJX	1
Part 2; Cohort 3; RJX	0

Number of participants with indicated AEs receiving RJX as assessed by CTCAE v4 03 (NCT03680105)
Timeframe: Up to Day 5 for Part 1 and Up to Day 12 for Part 2

Article	Year
Alcoholism and nutrition: a review of vitamin supplementation and treatment. Current opinion in clinical nutrition and metabolic care, 2020, Volume: 23, Issue:2 Topics: Alcoholism; Animals; Avitaminosis; Dietary Supplements; Disease Models, Animal; Humans; Niacin; Nutr	2020
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review. JAMA neurology, 2018, 08-01, Volume: 75, Issue:8 Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements;	2018
B vitamins and berries and age-related neurodegenerative disorders. Evidence report/technology assessment, 2006, Issue:134 Topics: Aging; Alzheimer Disease; Animals; Blueberry Plants; Cognition; Disease Models, Animal; Folic Acid;	2006
Cerebral thiamine-dependent enzyme changes in experimental Wernicke's encephalopathy. Metabolic brain disease, 1986, Volume: 1, Issue:3 Topics: Animals; Disease Models, Animal; Pyridinium Compounds; Pyrithiamine; Thiamine; Thiamine Deficiency;	1986

Article	Year
Thiamine deficiency and recovery: impact of recurrent episodes and beneficial effect of treatment with Trolox and dimethyl sulfoxide. Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Chromans; Dimethyl Sulfoxide; Dis	2021
Role of pyruvate in maintaining cell viability and energy production under high-glucose conditions. Scientific reports, 2021, 09-23, Volume: 11, Issue:1 Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Survival; Citric Acid Cycle; Diabetic Nephropathies	2021
B Vitamins Supplementation Can Improve Cognitive Functions and May Relate to the Enhancement of Transketolase Activity in A Rat Model of Cognitive Impairment Associated with High-fat Diets. Current medical science, 2021, Volume: 41, Issue:5 Topics: Animals; Cognitive Dysfunction; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Folic A	2021
Machine learning and murine models explain failures of clinical sepsis trials. The journal of trauma and acute care surgery, 2022, 08-01, Volume: 93, Issue:2 Topics: Animals; Ascorbic Acid; Biomarkers; Cecum; Cytokines; Disease Models, Animal; Hydrocortisone; Ligati	2022
Benfotiamine protects against hypothalamic dysfunction in a STZ-induced model of neurodegeneration in rats. Life sciences, 2022, Oct-01, Volume: 306 Topics: Alzheimer Disease; Animals; Disease Models, Animal; Rats; Streptozocin; Thiamine	2022
Evaluation of the potential of Rejuveinix plus dexamethasone against sepsis. Future microbiology, 2022, Volume: 17 Topics: Animals; Anti-Inflammatory Agents; Ascorbic Acid; COVID-19 Drug Treatment; Dexamethasone; Disease Mo	2022
Gut-Brain Axis: Insights from Hippocampal Neurogenesis and Brain Tumor Development in a Mouse Model of Experimental Colitis Induced by Dextran Sodium Sulfate. International journal of molecular sciences, 2022, Sep-29, Volume: 23, Issue:19 Topics: Amino Acids; Animals; Brain Neoplasms; Brain-Gut Axis; Carcinogenesis; Colitis; Colon; Cytokines; De	2022
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation. Nature communications, 2022, 12-21, Volume: 13, Issue:1 Topics: Animals; Biotin; Dietary Supplements; Disease Models, Animal; Humans; Huntington Disease; Mice; Mice	2022
Neuroprotective effects of vitamin B1 on memory impairment and suppression of pro-inflammatory cytokines in traumatic brain injury. Metabolic brain disease, 2023, Volume: 38, Issue:6 Topics: Animals; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Inflammation; Memory Disorder	2023
Vitamin B1 and B12 mitigates neuron apoptosis in cerebral palsy by augmenting BDNF expression through MALAT1/miR-1 axis. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:21 Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cerebral Palsy; Disease Mod	2019
Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats. PloS one, 2020, Volume: 15, Issue:5 Topics: Animals; Biomarkers; Cardiotoxins; Disease Models, Animal; Electrocardiography; Enzyme Inhibitors; H	2020
The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line. Chemico-biological interactions, 2021, May-01, Volume: 340 Topics: Animals; Anticonvulsants; Antioxidants; Apoptosis; Brain; Caspase 3; Cell Line; Disease Models, Anim	2021
Anti-convulsive Effect of Thiamine and Melatonin Combination in Mice: Involvement of Oxidative Stress. Central nervous system agents in medicinal chemistry, 2021, Volume: 21, Issue:2 Topics: Animals; Anticonvulsants; Disease Models, Animal; Male; Melatonin; Mice; Oxidative Stress; Pentylene	2021
Comparative effects of EtOH consumption and thiamine deficiency on cognitive impairment, oxidative damage, and β-amyloid peptide overproduction in the brain. Free radical biology & medicine, 2017, Volume: 108 Topics: Alcohol Drinking; Alcoholism; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Diet Thera	2017
Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels. Molecular and cellular neurosciences, 2017, Volume: 82 Topics: Animals; Dentate Gyrus; Disease Models, Animal; Glycogen Synthase Kinase 3; Hippocampus; Male; Mice,	2017
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. Nutritional neuroscience, 2019, Volume: 22, Issue:3 Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilep	2019
Elucidating the functions of brain GSK3α: Possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour. Behavioural brain research, 2017, 09-29, Volume: 335 Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Glycogen Synthase Kinase	2017
Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting. PLoS computational biology, 2018, Volume: 14, Issue:1 Topics: Animals; Choline; Culicidae; Disease Models, Animal; Food; Gene Deletion; Gene Expression Regulation	2018
The effect of thiamine and its metabolites on peripheral neuropathic pain induced by cisplatin in rats. Experimental animals, 2018, May-10, Volume: 67, Issue:2 Topics: Analgesics; Animals; Cisplatin; Disease Models, Animal; Interleukin-1beta; Male; Malondialdehyde; Ne	2018
Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer's disease, whereas amyloid deposition does not. Alzheimer's research & therapy, 2018, 03-01, Volume: 10, Issue:1 Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein	2018
Modulation of hepatic gene expression profiles by vitamin B Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2018, Volume: 43, Issue:8 Topics: Acute Disease; Animals; Dietary Supplements; Disease Models, Animal; Energy Metabolism; Gene Express	2018
Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. Human molecular genetics, 2018, 08-15, Volume: 27, Issue:16 Topics: Amyloid beta-Peptides; Animals; Antioxidant Response Elements; Brain; Disease Models, Animal; Humans	2018
New molecular aspects in the mechanism of oromaxillofacial cleft prevention by B-vitamins. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2018, Volume: 46, Issue:12 Topics: Animals; Biological Transport; Cleft Lip; Cleft Palate; Disease Models, Animal; Electrophoresis, Aga	2018
Vitamin B combination reduces fluconazole toxicity in Wistar rats. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2019, Volume: 27, Issue:1 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury;	2019
Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) Therapy Decreases Oxidative Stress, Improves Cardiovascular Function, and Improves Survival in Murine Sepsis. Shock (Augusta, Ga.), 2020, Volume: 53, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Blood Pressure; Disease Models, Anim	2020
The Effects of Thiamine Hydrochloride on Cardiac Function, Redox Status and Morphometric Alterations in Doxorubicin-Treated Rats. Cardiovascular toxicology, 2020, Volume: 20, Issue:2 Topics: Animals; Antioxidants; Cardiotoxicity; Coronary Circulation; Disease Models, Animal; Doxorubicin; Fe	2020
Lower concentrations of B-vitamin subgroups in the serum and amniotic fluid correlate to cleft lip and palate appearance in the offspring of A/WySn mice. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2013, Volume: 71, Issue:9 Topics: Adenine; Alkaline Phosphatase; Amniotic Fluid; Animals; Chromatography, High Pressure Liquid; Cleft	2013
Thiamine deficiency induces massive cell death in the olfactory bulbs of mice. Journal of neuropathology and experimental neurology, 2013, Volume: 72, Issue:12 Topics: Animals; Antimetabolites; Calcium-Binding Proteins; Caspase 3; Cell Death; Disease Models, Animal; D	2013
Effects of thiamine and thiamine pyrophosphate on epileptic episode model established with caffeine in rats. Epilepsy research, 2014, Volume: 108, Issue:3 Topics: Animals; Brain; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response R	2014
Associations between in vivo neuroimaging and postmortem brain cytokine markers in a rodent model of Wernicke's encephalopathy. Experimental neurology, 2014, Volume: 261 Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Creatine; Cytokines; Disease Models, Animal; Li	2014
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model. Cell death & disease, 2015, Jan-15, Volume: 6 Topics: Amyloid; Amyloid beta-Peptides; Animals; Brain; Caspase 3; Disease Models, Animal; Down-Regulation;	2015
Impact of exercise and vitamin B1 intake on hippocampal brain-derived neurotrophic factor and spatial memory performance in a rat model of stress. Journal of nutritional science and vitaminology, 2015, Volume: 61, Issue:1 Topics: Acetylcholine; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Hippocam	2015
Sex distribution is a factor in teratogenically induced clefts and in the anti-teratogenic effect of thiamine in mice, but not in genetically determined cleft appearance. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2016, Volume: 44, Issue:2 Topics: Animals; Cleft Lip; Cleft Palate; Disease Models, Animal; Female; Humans; Male; Mice; Mice, Inbred S	2016
Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. Critical care medicine, 2016, Volume: 44, Issue:9 Topics: Animals; Disease Models, Animal; Gastrointestinal Absorption; Intestinal Mucosa; Membrane Transport	2016
Thiamine as a neuroprotective agent after cardiac arrest. Resuscitation, 2016, Volume: 105 Topics: Animals; Biomarkers; Cardiopulmonary Resuscitation; Case-Control Studies; Cerebral Cortex; Disease M	2016
The influence of thiamin on the efficacy of pregabalin in rats with spinal nerve ligation (SNL)-induced neuropathic pain. Neurological research, 2016, Volume: 38, Issue:8 Topics: Analgesics; Analysis of Variance; Animals; Disease Models, Animal; Drug Administration Schedule; Dru	2016
Protective effect of treatment with thiamine or benfotiamine on liver oxidative damage in rat model of acute ethanol intoxication. Life sciences, 2016, Oct-01, Volume: 162 Topics: Alcoholic Intoxication; Animals; Disease Models, Animal; Liver Diseases; Male; Oxidative Stress; Rat	2016
Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice. Progress in neuro-psychopharmacology & biological psychiatry, 2017, 04-03, Volume: 75 Topics: Animals; Avoidance Learning; Brain; Cognition Disorders; Conditioning, Psychological; Disease Models	2017
Treatment of rats with the JAK-2 inhibitor fedratinib does not lead to experimental Wernicke's encephalopathy. Neuroscience letters, 2017, 03-06, Volume: 642 Topics: Animals; Disease Models, Animal; Janus Kinase 2; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sul	2017
Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides. Neurobiology of aging, 2011, Volume: 32, Issue:1 Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysi	2011
Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase. Alcoholism, clinical and experimental research, 2009, Volume: 33, Issue:6 Topics: Alcoholism; Amprolium; Animals; Cell Death; Cells, Cultured; Central Nervous System Depressants; Coc	2009
Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway. Circulation. Heart failure, 2010, Volume: 3, Issue:2 Topics: Analysis of Variance; Animals; Apoptosis; Blood Flow Velocity; Blotting, Western; Carrier Proteins;	2010
Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes. Diabetologia, 2010, Volume: 53, Issue:7 Topics: Adjuvants, Immunologic; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Kidney Glo	2010
Thiamine supplementation attenuated hepatocellular carcinoma in the Atp7b mouse model of Wilson's disease. Anticancer research, 2011, Volume: 31, Issue:10 Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Death	2011
Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice. Archives of Iranian medicine, 2012, Volume: 15, Issue:5 Topics: Animals; Anxiety; Behavior, Animal; Depression; Depression, Postpartum; Depressive Disorder, Major;	2012
Reversal of thiamine deficiency-induced neurodegeneration. Journal of neuropathology and experimental neurology, 2003, Volume: 62, Issue:2 Topics: Animals; Brain; Cell Death; Disease Models, Animal; Fluoresceins; Fluorescent Dyes; Heme Oxygenase (	2003
Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult. Behavioural brain research, 2004, Jan-05, Volume: 148, Issue:1-2 Topics: Aging; Amnesia; Animals; Antimetabolites; Behavior, Animal; Body Weight; Brain Mapping; Cell Count;	2004
Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha. Neuroscience letters, 2006, Feb-13, Volume: 394, Issue:2 Topics: Adjuvants, Immunologic; Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimenta	2006
Development and resolution of brain lesions caused by pyrithiamine- and dietary-induced thiamine deficiency and alcohol exposure in the alcohol-preferring rat: a longitudinal magnetic resonance imaging and spectroscopy study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:5 Topics: Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Antimetabolites; Biomarkers; Brain;	2007
Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice. Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:8 Topics: Amphetamines; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleran	2007
Restoration of thiamine status with white or whole wheat bread in a thiamine-depleted rat model. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2007, Volume: 77, Issue:1 Topics: Animals; Body Weight; Bread; Cerebellum; Diet; Disease Models, Animal; Glucose; Glutamic Acid; Kidne	2007
Effect of diltiazem isomers and thiamine on piglet liver microsomal peroxidation using dichlorofluorescein. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2007, Volume: 10, Issue:3 Topics: Animals; Antioxidants; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Dose-Response Re	2007
Properties of thiamine transport in isolated perfused hearts of chronically alcoholic guinea pigs. Canadian journal of physiology and pharmacology, 2008, Volume: 86, Issue:4 Topics: Alcoholism; Animals; Biological Transport, Active; Carbon Radioisotopes; Carbonyl Cyanide m-Chloroph	2008
[The effects of chronic methamphetamine and single haloperidol injections on thiamine and its phosphate ester levels in the rat brain]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1984, Volume: 4, Issue:2 Topics: Animals; Brain; Disease Models, Animal; Haloperidol; Humans; Male; Methamphetamine; Rats; Rats, Inbr	1984
Low energy levels in thiamine-deficient encephalopathy. Journal of neuropathology and experimental neurology, 1984, Volume: 43, Issue:3 Topics: Animals; Behavior, Animal; Brain; Brain Diseases; Disease Models, Animal; Energy Metabolism; Male; M	1984
Sequence of metabolic, clinical, and histological events in experimental thiamine deficiency. Annals of neurology, 1983, Volume: 13, Issue:4 Topics: Animals; Brain; Cerebrovascular Circulation; Disease Models, Animal; Glucose; Male; Rats; Rats, Inbr	1983
The adequacy of thiamine in liquid diets used in animal models of alcoholism. Experientia, 1980, Jul-15, Volume: 36, Issue:7 Topics: Alcoholism; Animals; Brain; Disease Models, Animal; Ethanol; Food, Formulated; Humans; Male; Nutriti	1980
A sulphite-oxidase-deficient rat model: subchronic toxicology. Food and cosmetics toxicology, 1981, Volume: 19, Issue:2 Topics: Adenocarcinoma; Animals; Body Weight; Diarrhea; Disease Models, Animal; Drinking; Eating; Female; Gl	1981
In vivo/in vitro studies on the effects of cyclophosphamide on growth and differentiation of hamster palate. Anti-cancer drugs, 1996, Volume: 7, Issue:2 Topics: Animals; Collagen; Cricetinae; Cyclophosphamide; Disease Models, Animal; Drug Therapy, Combination;	1996
Application of thiamine in preventing malformations, specifically cleft alveolus and palate, during the intrauterine development of rats. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 1997, Volume: 34, Issue:4 Topics: Abnormalities, Drug-Induced; Alveolar Process; Animals; Body Weight; Bone and Bones; Cleft Palate; C	1997
Antinociceptive effect following dietary-induced thiamine deficiency in mice: involvement of substance P and somatostatin. Life sciences, 2001, Jul-27, Volume: 69, Issue:10 Topics: Analgesia; Animals; Avoidance Learning; Behavior, Animal; Diet; Disease Models, Animal; Hindlimb; In	2001
Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice. Life sciences, 2001, Jul-27, Volume: 69, Issue:10 Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Weight; Depression; Diet; Disease	2001
B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice. European journal of pharmacology, 2001, Jun-15, Volume: 421, Issue:3 Topics: Acetic Acid; Animals; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Edema;	2001
Analysis of aversively conditioned learning and memory in rats recovered from pyrithiamine-induced thiamine deficiency. Behavioral neuroscience, 1991, Volume: 105, Issue:3 Topics: Alcohol Amnestic Disorder; Analysis of Variance; Animals; Avoidance Learning; Discrimination Learnin	1991
[The vitamin B1 and C content in the tissues of animals with thyrotoxicosis]. Vrachebnoe delo, 1989, Issue:10 Topics: Animals; Ascorbic Acid; Disease Models, Animal; Liver; Rats; Thiamine; Thyrotoxicosis; Thyroxine; Ti	1989
[Teratogen-modified palatogenesis in the Uje: WIST rat. 2. The effect of thiamine on the incidence of cheilognathopalatoschisis]. Zahn-, Mund-, und Kieferheilkunde mit Zentralblatt, 1987, Volume: 75, Issue:6 Topics: Animals; Cleft Lip; Cleft Palate; Disease Models, Animal; Female; Glycine; Maxilla; Palate; Pregnanc	1987
Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-Ketoglutarate dehydrogenase. Neurochemical research, 1986, Volume: 11, Issue:4 Topics: Animals; Brain; Diet; Disease Models, Animal; Ketoglutarate Dehydrogenase Complex; Ketone Oxidoreduc	1986
Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy: 1. The pyruvate dehydrogenase complex. Neurochemical research, 1985, Volume: 10, Issue:10 Topics: Animals; Brain Diseases, Metabolic; Brain Stem; Disease Models, Animal; Male; Pyrithiamine; Pyruvate	1985
Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes. Electroencephalography and clinical neurophysiology, 1973, Volume: 35, Issue:2 Topics: Animals; Body Temperature; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, A	1973
Experimental protein malnutrition in primates--cytochemistry of the nervous system. American journal of physical anthropology, 1973, Volume: 38, Issue:2 Topics: Acetylcholinesterase; Acid Phosphatase; Adenosine Triphosphatases; Animals; Central Nervous System;	1973
[Treatment of acute experimental lymphostatic edema with vitamins, with vitamin-like natural substances and with massage]. Angiologica, 1971, Volume: 8, Issue:1 Topics: Animals; Ascorbic Acid; Coumarins; Disease Models, Animal; Ligation; Lymphatic Diseases; Male; Massa	1971
Cobalt cardiomyopathy. Experimental basis for the human lesion. Pathologia et microbiologia, 1970, Volume: 35, Issue:1 Topics: Animals; Beer; Cardiomyopathies; Cobalt; Disease Models, Animal; Electrocardiography; Fatty Acids; H	1970

thiamine and Disease Models, Animal