thiamine has been researched along with Diabetic Retinopathy in 11 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human microvascular endothelial cells (HMECs), retinal pericytes (HRPs) and Müller cells (MIO-M1) were cultured in intermittent high glucose (intHG) and/or hypoxia, with addition of fenofibrate or thiamine." | 7.96 | Effects of thiamine and fenofibrate on high glucose and hypoxia-induced damage in cell models of the inner blood-retinal barrier. ( Beltramo, E; Gai, C; Mazzeo, A; Porta, M; Trento, M, 2020) |
| "Human microvascular endothelial cells (HMECs), retinal pericytes (HRPs) and Müller cells (MIO-M1) were cultured in intermittent high glucose (intHG) and/or hypoxia, with addition of fenofibrate or thiamine." | 3.96 | Effects of thiamine and fenofibrate on high glucose and hypoxia-induced damage in cell models of the inner blood-retinal barrier. ( Beltramo, E; Gai, C; Mazzeo, A; Porta, M; Trento, M, 2020) |
| " We aimed at investigating whether pulsed exposure to different glucose concentrations influences apoptosis in human retinal pericytes (HRP) versus bovine retinal pericytes (BRP), with consequences on the onset of diabetic retinopathy, and the possible protective role of thiamine." | 3.75 | Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine. ( Beltramo, E; Berrone, E; Porta, M; Tarallo, S, 2009) |
| "Hyperglycemia is a causal factor in the development of the vascular complications of diabetes." | 1.33 | Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. ( Ape, AU; Beltramo, E; Berrone, E; Porta, M; Solimine, C, 2006) |
| "Thiamine treatment limited this inhibitory effect of elevated glucose levels on BAECs." | 1.31 | Thiamine reverses hyperglycemia-induced dysfunction in cultured endothelial cells. ( Ascher, E; Gade, PV; Hingorani, A; Jacob, T; Kallakuri, S; Puthukkeril, S; Scheinman, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Mazzeo, A | 1 |
| Gai, C | 1 |
| Trento, M | 1 |
| Porta, M | 5 |
| Beltramo, E | 5 |
| Berrone, E | 4 |
| Tarallo, S | 3 |
| Nizheradze, K | 1 |
| Hammes, HP | 1 |
| Du, X | 1 |
| Edelstein, D | 1 |
| Taguchi, T | 1 |
| Matsumura, T | 1 |
| Ju, Q | 1 |
| Lin, J | 1 |
| Bierhaus, A | 1 |
| Nawroth, P | 1 |
| Hannak, D | 1 |
| Neumaier, M | 1 |
| Bergfeld, R | 1 |
| Giardino, I | 1 |
| Brownlee, M | 1 |
| Watanabe, D | 1 |
| Takagi, H | 1 |
| Solimine, C | 1 |
| Ape, AU | 1 |
| Rieder, HP | 1 |
| Berger, W | 1 |
| Fridrich, R | 1 |
| Ascher, E | 1 |
| Gade, PV | 1 |
| Hingorani, A | 1 |
| Puthukkeril, S | 1 |
| Kallakuri, S | 1 |
| Scheinman, M | 1 |
| Jacob, T | 1 |
| Taniguchi, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318] | Phase 4 | 86 participants (Anticipated) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thiamine and Diabetic Retinopathy
| Article | Year |
|---|---|
[Potential pharmacological treatments for diabetic retinopathy].
Topics: Aldehyde Reductase; Antioxidants; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diabetic Reti | 2005 |
10 other studies available for thiamine and Diabetic Retinopathy
| Article | Year |
|---|---|
Effects of thiamine and fenofibrate on high glucose and hypoxia-induced damage in cell models of the inner blood-retinal barrier.
Topics: Blood-Retinal Barrier; Cell Hypoxia; Cells, Cultured; Diabetic Retinopathy; Dose-Response Relationsh | 2020 |
Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cattle; Cell Line; Cells, Cultured; Di | 2009 |
Thiamine and benfotiamine prevent apoptosis induced by high glucose-conditioned extracellular matrix in human retinal pericytes.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Adhesion; Cell Proliferation; Cells, Cultured; Cytopr | 2009 |
Human pericyte-endothelial cell interactions in co-culture models mimicking the diabetic retinal microvascular environment.
Topics: Apoptosis; Cell Communication; Cell Proliferation; Cells, Cultured; Coculture Techniques; Diabetic R | 2012 |
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Topics: Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium | 2003 |
[Diabetes mellitus. Retinal lesions should not exist!].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Activation; Glycated Hemoglob | 2004 |
Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose.
Topics: Aldehyde Reductase; Animals; Cattle; Cell Culture Techniques; Chelating Agents; Diabetic Retinopathy | 2006 |
[Vitamin status in diabetic neuropathy (thiamine, riboflavin, pyridoxin, cobalamin and tocopherol)].
Topics: Diabetes Complications; Diabetes Mellitus; Diabetic Neuropathies; Diabetic Retinopathy; Female; Huma | 1980 |
Thiamine reverses hyperglycemia-induced dysfunction in cultured endothelial cells.
Topics: Animals; Cattle; Cell Count; Cell Division; Cell Movement; Cells, Cultured; Diabetic Retinopathy; En | 2001 |
[Experiences with miscellaneous medical treatments of diabetic retinopathy].
Topics: Anticholesteremic Agents; Dextrans; Diabetic Retinopathy; Humans; Inositol; Nicotinic Acids; Sulfate | 1969 |