Page last updated: 2024-10-20

thiamine and Diabetes Mellitus, Type 2

thiamine has been researched along with Diabetes Mellitus, Type 2 in 52 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Research Excerpts

ExcerptRelevanceReference
"During weight loss, erythrocyte thiamine pyrophosphate (TPP) decreased (221±52 to 195±39 nmol/L, P<0."9.16Increased thiamine intake may be required to maintain thiamine status during weight loss in patients with type 2 diabetes. ( Brinkworth, GD; Cleanthous, X; Clifton, PM; Keogh, JB; Noakes, M; Wycherley, TP, 2012)
"High-dose supplements of thiamine prevent the development of microalbuminuria in experimental diabetes."9.14High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. ( Akhtar, MW; Alam, SS; Larkin, JR; Rabbani, N; Riaz, S; Shafi, T; Thornalley, PJ, 2009)
" The diabetic states that associate with these genetic variants are MODY 2, thiamine responsive anaemia syndrome (TRAS) and mitochondrial diabetes."8.81Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology? ( Maassen, JA, 2002)
" We herein report a case of cardiac dysfunction due to thiamine deficiency after hemodialysis in a patient with suspected biguanide-related lactic acidosis."8.12Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis. ( Jimura, F; Kachi, N; Tamaki, H; Tsushima, H, 2022)
"The present study aimed to determine thiamine intake levels and the association between thiamine intake, diabetes, cardiovascular diseases and mental health."8.02Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study. ( Duc, HN; Kim, MS; Oh, H; Yoon, IM, 2021)
" We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency."7.85The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation. ( Fujita, M; Godo, S; Kudo, D; Kushimoto, S; Nomura, R; Shimokawa, H; Yoshida, Y, 2017)
"Thiamine is a coenzyme important in intracellular glucose metabolism."6.72Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. ( Abularrage, CJ; Arora, S; Kellicut, D; Lidor, A; Nylen, E; Sidawy, AN; Weiswasser, JM, 2006)
"Thiamine deficiency has been linked to microvascular complications in patients with diabetes mellitus (DM)."5.38Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria. ( Abd-Alrahman, SH; Al-Attas, OS; Al-Daghri, NM; Alfadda, AA; Sabico, S, 2012)
"Wolfram syndrome, Kearns-Sayre syndrome, thiamine-responsive megaloblastic anemia, and maternally inherited diabetes and deafness are genetic disorders characterized by diabetes, impaired hearing, and vision."5.22Diabetes Out-of-the-Box: Diabetes Mellitus and Impairment in Hearing and Vision. ( Gruber, N; Pinhas-Hamiel, O, 2022)
"Twelve hyperglycemic subjects (10 cases of impaired glucose tolerance and 2 new cases of type 2 diabetes) completed this randomized, double-blind trial, where all participants received both placebo and thiamine capsules (3 × 100 mg/day) for 6 weeks in a cross-over manner."5.17High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial. ( Alaei Shahmiri, F; Sherriff, J; Soares, MJ; Zhao, Y, 2013)
"During weight loss, erythrocyte thiamine pyrophosphate (TPP) decreased (221±52 to 195±39 nmol/L, P<0."5.16Increased thiamine intake may be required to maintain thiamine status during weight loss in patients with type 2 diabetes. ( Brinkworth, GD; Cleanthous, X; Clifton, PM; Keogh, JB; Noakes, M; Wycherley, TP, 2012)
"High-dose supplements of thiamine prevent the development of microalbuminuria in experimental diabetes."5.14High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. ( Akhtar, MW; Alam, SS; Larkin, JR; Rabbani, N; Riaz, S; Shafi, T; Thornalley, PJ, 2009)
" The diabetic states that associate with these genetic variants are MODY 2, thiamine responsive anaemia syndrome (TRAS) and mitochondrial diabetes."4.81Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology? ( Maassen, JA, 2002)
" We herein report a case of cardiac dysfunction due to thiamine deficiency after hemodialysis in a patient with suspected biguanide-related lactic acidosis."4.12Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis. ( Jimura, F; Kachi, N; Tamaki, H; Tsushima, H, 2022)
"The present study aimed to determine thiamine intake levels and the association between thiamine intake, diabetes, cardiovascular diseases and mental health."4.02Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study. ( Duc, HN; Kim, MS; Oh, H; Yoon, IM, 2021)
" We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency."3.85The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation. ( Fujita, M; Godo, S; Kudo, D; Kushimoto, S; Nomura, R; Shimokawa, H; Yoshida, Y, 2017)
" Currently, there are only few pathogenetically oriented pharmacotherapies for DSPN, one of which is benfotiamine, a prodrug of thiamine with a high bioavailability and favourable safety profile."3.11BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy. ( Al-Hasani, H; Bönhof, GJ; Herder, C; Icks, A; Knebel, B; Kuss, O; Reule, C; Roden, M; Sipola, G; Strassburger, K; Strom, A; Wollmann, JC; Ziegler, D, 2022)
"In people with Type 2 diabetes and markedly impaired fasting flow-mediated dilatation, a mixed test meal does not further deteriorate flow-mediated dilatation or variables of microvascular or autonomic nervous function."2.78A randomized, double-blind, crossover, placebo-controlled trial of 6 weeks benfotiamine treatment on postprandial vascular function and variables of autonomic nerve function in Type 2 diabetes. ( Pop, A; Stirban, A; Tschoepe, D, 2013)
"Patients with type 2 diabetes and urinary albumin excretion in the high-normal and microalbuminuric range (15-300 mg/24h) were randomized to receive benfotiamine (n = 39) or placebo (n = 43)."2.77Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy. ( Alkhalaf, A; Bakker, SJ; Bilo, HJ; Gans, RO; Groenier, KH; Heeringa, P; Kleefstra, N; Navis, GJ; Schalkwijk, CG; Scheijen, JL, 2012)
"Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to 12 weeks of benfotiamine (900 mg/day) (n = 39) or placebo (n = 43)."2.75A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy. ( Achenbach, U; Alkhalaf, A; Bakker, SJ; Bilo, HJ; Gans, RO; Kleefstra, N; Klooster, A; Mijnhout, GS; Navis, GJ; Slingerland, RJ; van Oeveren, W, 2010)
"165 patients with symmetrical, distal diabetic polyneuropathy were randomised to one of three treatment groups entering the wash-out phase and 133/124 patients were analysed in the ITT/PP analysis: Benfotiamine 600 mg per day (n=47/43), benfotiamine 300 mg per day (n=45/42) or placebo (n=41/39)."2.73Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. ( Achenbach, U; Bretzel, RG; Federlin, K; Gaus, W; Stracke, H, 2008)
"Thiamine is a coenzyme important in intracellular glucose metabolism."2.72Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. ( Abularrage, CJ; Arora, S; Kellicut, D; Lidor, A; Nylen, E; Sidawy, AN; Weiswasser, JM, 2006)
"Thirteen people with type 2 diabetes were given a heat-processed test meal with a high AGE content (HAGE; 15."2.72Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. ( Gawlowski, T; Götting, C; Horstmann, T; Kleesiek, K; Koschinsky, T; Mueller-Roesel, M; Negrean, M; Stirban, A; Stratmann, B; Tschoepe, D; Uribarri, J; Vlassara, H, 2006)
"Type 2 diabetes was defined as a fasting serum HbA1c level of 6."1.72Associations between Adherence to the Taiwan Dietary Reference Intakes of Micronutrients and the Risk of Type 2 Diabetes. ( Li, MC, 2022)
"Thiamine deficiency was highly prevalent in all groups, whereas low vitamin B₁₂ and elevated methylmalonic acid were rare."1.42Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. ( Bangert, V; Hostalek, U; Kaiser, RP; Nix, WA; Obeid, R; Schilling, M; Zirwes, R, 2015)
"A 59-year-old man with type 2 diabetes mellitus (without treatment two weeks before the intoxication) intentionally ingested a substantial amount of ethanol along with ~750 mL of laminate floor cleaner containing citric acid."1.40Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake. ( Beijnen, JH; Brandjes, DP; Daling, R; Hendrikx, JJ; Hooijberg, JH; Huitema, AD; Lagas, JS; Schellens, JH, 2014)
"Thiamine deficiency has been linked to microvascular complications in patients with diabetes mellitus (DM)."1.38Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria. ( Abd-Alrahman, SH; Al-Attas, OS; Al-Daghri, NM; Alfadda, AA; Sabico, S, 2012)
"One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited."1.38Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation. ( Adaikalakoteswari, A; Adam, JM; Kariadi, SH; Rabbani, N; Thornalley, PJ; Tjokroprawiro, A; Waspadji, S, 2012)
"The presence of Wernicke encephalopathy in alcoholics with diabetic ketoacidosis, suggests that metabolic decompensation is essential in the onset of the disease."1.35Wernicke encephalopathy in alcoholics with diabetic ketoacidosis. ( Chamorro, AJ; Garcia-Diez, LC; Luna, G; Marcos-Martin, M; Martin-Polo, J, 2009)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (3.85)18.2507
2000's17 (32.69)29.6817
2010's25 (48.08)24.3611
2020's8 (15.38)2.80

Authors

AuthorsStudies
Bönhof, GJ1
Sipola, G1
Strom, A1
Herder, C1
Strassburger, K1
Knebel, B1
Reule, C1
Wollmann, JC1
Icks, A1
Al-Hasani, H1
Roden, M1
Kuss, O1
Ziegler, D1
Tamaki, H1
Tsushima, H1
Kachi, N1
Jimura, F1
Zheng, Y1
Xu, Z1
Chen, X1
Ma, W1
Cai, J1
Ma, A1
Gruber, N1
Pinhas-Hamiel, O1
Li, MC1
Wang, L1
Yang, C1
Song, F1
Liu, Z1
Liu, S1
Piuri, G1
Zocchi, M1
Della Porta, M1
Ficara, V1
Manoni, M1
Zuccotti, GV1
Pinotti, L1
Maier, JA1
Cazzola, R1
Duc, HN1
Oh, H1
Yoon, IM1
Kim, MS1
Chalásová, K1
Pácal, L1
Pleskačová, A1
Knopfová, L1
Řehořová, J1
Tomandlová, M1
Tomandl, J1
Kaňková, K1
Liang, X1
Yee, SW1
Chien, HC1
Chen, EC1
Luo, Q1
Zou, L1
Piao, M1
Mifune, A1
Chen, L1
Calvert, ME1
King, S1
Norheim, F1
Abad, J1
Krauss, RM1
Giacomini, KM1
Karkabounas, S1
Papadopoulos, N1
Anastasiadou, C1
Gubili, C1
Peschos, D1
Daskalou, T1
Fikioris, N1
Simos, YV1
Kontargiris, E1
Gianakopoulos, X1
Ragos, V1
Chatzidimitriou, M1
Stirban, A5
Pop, A2
Tschoepe, D4
Alaei Shahmiri, F1
Soares, MJ1
Zhao, Y1
Sherriff, J1
Chen, Z1
Zhong, C1
Fischer, A1
Heckermann, S1
Sergienko, VA1
Segin, VB1
Samir, A1
Sergienko, AA1
Hendrikx, JJ1
Lagas, JS1
Daling, R1
Hooijberg, JH1
Schellens, JH1
Beijnen, JH1
Brandjes, DP1
Huitema, AD1
Nix, WA1
Zirwes, R1
Bangert, V1
Kaiser, RP1
Schilling, M1
Hostalek, U1
Obeid, R1
Ruiz Bajo, B1
Moreno García, MP1
Rueda Mena, E1
González Chinchón, G1
Riaz, S3
Luo, G1
He, J1
Wu, T1
Huang, Y1
Miao, Z1
Zhao, Z1
Wang, X1
Wang, Y1
Godo, S1
Yoshida, Y1
Fujita, M1
Kudo, D1
Nomura, R1
Shimokawa, H1
Kushimoto, S1
Vindedzis, SA1
Stanton, KG1
Sherriff, JL1
Dhaliwal, SS1
Wong, CY1
Qiuwaxi, J1
Chen, H1
Li, SW1
Chan, HT1
Tam, S1
Shu, XO1
Lau, CP1
Kwong, YL1
Tse, HF1
Rabbani, N4
Alam, SS1
Larkin, JR1
Akhtar, MW1
Shafi, T1
Thornalley, PJ4
Alkhalaf, A3
Kleefstra, N3
Groenier, KH2
Bakker, SJ3
Navis, GJ3
Bilo, HJ3
Chamorro, AJ1
Marcos-Martin, M1
Martin-Polo, J1
Garcia-Diez, LC1
Luna, G1
Klooster, A1
van Oeveren, W1
Achenbach, U2
Slingerland, RJ1
Mijnhout, GS1
Gans, RO2
González-Ortiz, M1
Martínez-Abundis, E1
Robles-Cervantes, JA1
Ramírez-Ramírez, V1
Ramos-Zavala, MG1
Skinner, V1
Srai, SK1
Al-Attas, OS1
Al-Daghri, NM1
Alfadda, AA1
Abd-Alrahman, SH1
Sabico, S1
Adaikalakoteswari, A1
Waspadji, S1
Tjokroprawiro, A1
Kariadi, SH1
Adam, JM1
Polizzi, FC1
Andican, G2
Çetin, E2
Civelek, S2
Yumuk, V2
Burçak, G2
Heeringa, P1
Scheijen, JL1
Schalkwijk, CG2
Keogh, JB1
Cleanthous, X1
Wycherley, TP1
Brinkworth, GD1
Noakes, M1
Clifton, PM1
Engelen, L1
Stehouwer, CD1
Candan Polizzi, F1
Maassen, JA1
Muroyama, K1
Murosaki, S1
Yamamoto, Y1
Odaka, H1
Chung, HC1
Miyoshi, M1
Haupt, E1
Ledermann, H1
Köpcke, W1
Agte, VV1
Nagmote, RV1
Tarwadi, KV1
Arora, S1
Lidor, A1
Abularrage, CJ1
Weiswasser, JM1
Nylen, E1
Kellicut, D1
Sidawy, AN1
Negrean, M2
Stratmann, B2
Gawlowski, T1
Horstmann, T1
Götting, C2
Kleesiek, K2
Mueller-Roesel, M1
Koschinsky, T1
Uribarri, J1
Vlassara, H1
Jermendy, G1
Salomon, J1
Babaei-Jadidi, R1
Al Ali, H1
Antonysunil, A1
Larkin, J1
Ahmed, A1
Rayman, G1
Bodmer, CW1
Stracke, H1
Gaus, W1
Federlin, K1
Bretzel, RG1
Straub, RH1
Rokitzki, L1
Schumacher, T1
Hillmann, C1
Palitzsch, KD1
Schölmerich, J1
Sadekov, RA1
Danilov, AB1
Veĭn, AM1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Serum Magnesium Level in Type 2 Diabetes Mellitus[NCT06059833]120 participants (Anticipated)Observational2023-09-30Not yet recruiting
Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS) in Perioperative Stress Response[NCT05663164]30 participants (Actual)Interventional2022-10-01Completed
Pirofosfato de Tiamina Como Coadyuvante de la Metformina en el Tratamiento de Pacientes Con Diabetes Mellitus Tipo 2[NCT04053621]92 participants (Anticipated)Interventional2021-01-31Not yet recruiting
The Vitamin B Status in Type 2 Diabetes (VITA) Study[NCT03447275]174 participants (Actual)Observational2011-01-31Completed
A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318]Phase 486 participants (Anticipated)Interventional2007-12-31Completed
Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System[NCT00446810]Phase 430 participants (Anticipated)Interventional2007-09-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for thiamine and Diabetes Mellitus, Type 2

ArticleYear
Diabetes Out-of-the-Box: Diabetes Mellitus and Impairment in Hearing and Vision.
    Current diabetes reports, 2022, Volume: 22, Issue:9

    Topics: Anemia, Megaloblastic; Deafness; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hearing; Hearing Loss

2022
Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes.
    Nutrients, 2021, Jan-22, Volume: 13, Issue:2

    Topics: Adult; Child; Diabetes Mellitus, Type 2; Dietary Supplements; Gastrointestinal Microbiome; Humans; M

2021
Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies.
    Progress in neurobiology, 2013, Volume: 108

    Topics: Alzheimer Disease; Biomarkers; Brain Chemistry; Diabetes Mellitus, Type 2; Glucose; Glucose Transpor

2013
Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1.
    Journal of diabetes research, 2015, Volume: 2015

    Topics: Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Gene Expression

2015
Drugs for the treatment of diabetes complications. Zycose: a new player in the field?
    Drugs of today (Barcelona, Spain : 1998), 2008, Volume: 44, Issue:10

    Topics: 4-Aminobenzoic Acid; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus, T

2008
Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy.
    Diabetes, obesity & metabolism, 2011, Volume: 13, Issue:7

    Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropat

2011
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
    Diabetes, obesity & metabolism, 2013, Volume: 15, Issue:8

    Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie

2013
Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology?
    Panminerva medica, 2002, Volume: 44, Issue:4

    Topics: Anemia, Megaloblastic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Mitochondrial Diseases;

2002

Trials

18 trials available for thiamine and Diabetes Mellitus, Type 2

ArticleYear
BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy.
    BMJ open, 2022, Feb-03, Volume: 12, Issue:2

    Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Humans; Polyneuropathies; Qua

2022
Effects of α-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study.
    Journal of medicinal food, 2018, Volume: 21, Issue:12

    Topics: Administration, Oral; Blood Glucose; Carnosine; Diabetes Mellitus, Type 2; Dietary Supplements; Doub

2018
A randomized, double-blind, crossover, placebo-controlled trial of 6 weeks benfotiamine treatment on postprandial vascular function and variables of autonomic nerve function in Type 2 diabetes.
    Diabetic medicine : a journal of the British Diabetic Association, 2013, Volume: 30, Issue:10

    Topics: Adult; Aged; Antioxidants; Autonomic Pathways; Biomarkers; Blood Glucose; Cross-Over Studies; Diabet

2013
High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial.
    European journal of nutrition, 2013, Volume: 52, Issue:7

    Topics: Adult; Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Supplements; Dose

2013
Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence of benfotiamine treatment.
    Diabetes technology & therapeutics, 2013, Volume: 15, Issue:9

    Topics: Adult; Aged; Chelating Agents; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus, Type 2

2013
High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study.
    Diabetologia, 2009, Volume: 52, Issue:2

    Topics: Albuminuria; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Glomerular Filtration R

2009
A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy.
    Diabetes care, 2010, Volume: 33, Issue:7

    Topics: Adjuvants, Immunologic; Adult; Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotens

2010
Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes.
    European journal of nutrition, 2011, Volume: 50, Issue:2

    Topics: Adult; Aged; Biomarkers; Blood Glucose; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Cyto

2011
Effect of high dose thiamine on the levels of urinary protein biomarkers in diabetes mellitus type 2.
    Journal of pharmaceutical and biomedical analysis, 2011, Mar-25, Volume: 54, Issue:4

    Topics: Adult; Aged; Albuminuria; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type

2011
Increased DNA-glycation in type 2 diabetic patients: the effect of thiamine and pyridoxine therapy.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2012, Volume: 120, Issue:6

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; DNA; Female; Glycated Hemogl

2012
Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Aged; Biomarkers; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endoth

2012
Increased thiamine intake may be required to maintain thiamine status during weight loss in patients with type 2 diabetes.
    Diabetes research and clinical practice, 2012, Volume: 98, Issue:3

    Topics: Animals; Body Mass Index; Diabetes Mellitus, Type 2; Diet, Reducing; Dietary Proteins; Erythrocytes;

2012
Plasma AGE-peptides and C-peptide in early-stage diabetic nephropathy patients on thiamine and pyridoxine therapy.
    Minerva medica, 2013, Volume: 104, Issue:1

    Topics: Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Diabetic Nephropathies

2013
Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study).
    International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:2

    Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type

2005
Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia.
    Annals of vascular surgery, 2006, Volume: 20, Issue:5

    Topics: Adult; Aged; Blood Flow Velocity; Blood Glucose; Brachial Artery; Diabetes Mellitus, Type 2; Endothe

2006
Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.
    Diabetes care, 2006, Volume: 29, Issue:9

    Topics: Adjuvants, Immunologic; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; En

2006
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2008, Volume: 116, Issue:10

    Topics: Adjuvants, Immunologic; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic

2008
[Diabetic polyneuropathy treatment by milgamma-100 preparation].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1998, Volume: 98, Issue:9

    Topics: Adult; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Therapy, Combination

1998

Other Studies

26 other studies available for thiamine and Diabetes Mellitus, Type 2

ArticleYear
Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis.
    Internal medicine (Tokyo, Japan), 2022, Oct-01, Volume: 61, Issue:19

    Topics: Acidosis, Lactic; Beriberi; Biguanides; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypoglyce

2022
Thiamin and riboflavin status with related enzyme activities in pulmonary tuberculosis with diabetes mellitus in Shandong province of China.
    Asia Pacific journal of clinical nutrition, 2022, Volume: 31, Issue:2

    Topics: China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Riboflavin; Riboflavin Deficiency

2022
Associations between Adherence to the Taiwan Dietary Reference Intakes of Micronutrients and the Risk of Type 2 Diabetes.
    International journal of environmental research and public health, 2022, 09-27, Volume: 19, Issue:19

    Topics: Calcium; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet; Female; Glycated Hemoglobin; Huma

2022
Therapeutic Effectiveness of
    Journal of agricultural and food chemistry, 2020, Sep-09, Volume: 68, Issue:36

    Topics: Amino Acids; Animals; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Gardenia; Humans; Male; Meta

2020
Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study.
    Journal of nutritional science, 2021, Volume: 10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Child; Child, Preschool; Cross-

2021
Transketolase Activity but not Thiamine Membrane Transport Change in Response to Hyperglycaemia and Kidney Dysfunction.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2018, Volume: 126, Issue:4

    Topics: Adult; Aged; Biological Transport; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Erythrocytes;

2018
Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
    PLoS biology, 2018, Volume: 16, Issue:4

    Topics: Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Diabete

2018
[The effect of long-chain polyunsaturated higher ω-3 fatty acids, benfotiamine and α-lipoic acid on the lipid metabolism in patients with diabetes mellitus type 2 and cardiovascular autonomic neuropathy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2013, Volume: 113, Issue:11

    Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; D

2013
Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake.
    Basic & clinical pharmacology & toxicology, 2014, Volume: 115, Issue:5

    Topics: Acidosis; Acidosis, Lactic; Alcoholic Intoxication; Citric Acid; Diabetes Mellitus, Type 2; Humans;

2014
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.
    Diabetes research and clinical practice, 2015, Volume: 107, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Biomarkers; Case-Control Studies; Diabetes Mellitus, Ty

2015
Atypical presentation of Wernicke syndrome with magnetic resonance imaging showing cerebellar involvement and no changes in typical regions.
    Neurologia (Barcelona, Spain), 2016, Volume: 31, Issue:7

    Topics: Cerebellum; Diabetes Mellitus, Type 2; Female; Humans; Liver Diseases, Alcoholic; Magnetic Resonance

2016
The Therapeutic Effect of Stellate Ganglion Block on Facial Nerve Palsy in Patients with Type 2 Diabetes Mellitus.
    European neurology, 2015, Volume: 74, Issue:1-2

    Topics: Adult; Anesthetics, Local; Antipyrine; Aspirin; Autonomic Nerve Block; Blood Glucose; Dexamethasone;

2015
The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation.
    Internal medicine (Tokyo, Japan), 2017, Volume: 56, Issue:4

    Topics: Acidosis, Lactic; Aged; Biguanides; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Humans;

2017
Thiamine deficiency in diabetes - is diet relevant?
    Diabetes & vascular disease research, 2008, Volume: 5, Issue:3

    Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diet; Dietary Supplements; Female

2008
Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes.
    Molecular nutrition & food research, 2008, Volume: 52, Issue:12

    Topics: Brachial Artery; Cell Count; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelial Cells; En

2008
Thiamine in diabetic nephropathy: a novel treatment modality?
    Diabetologia, 2009, Volume: 52, Issue:6

    Topics: Albuminuria; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin;

2009
Wernicke encephalopathy in alcoholics with diabetic ketoacidosis.
    Internal medicine (Tokyo, Japan), 2009, Volume: 48, Issue:13

    Topics: Aged; Alcoholism; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Insulin; Magnetic Resona

2009
Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:11

    Topics: Adolescent; Adult; Aged; Albuminuria; Blood Glucose; Child; Child, Preschool; Cholesterol; Chromatog

2012
Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation.
    Diabetes research and clinical practice, 2012, Volume: 95, Issue:3

    Topics: Albuminuria; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Indonesia; In

2012
Anti-obesity effects of a mixture of thiamin, arginine, caffeine, and citric acid in non-insulin dependent diabetic KK mice.
    Journal of nutritional science and vitaminology, 2003, Volume: 49, Issue:1

    Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Arginine; Caffeine; Citric Acid; Diabetes Mellitus, Ty

2003
[Oral benfotiamine therapy. Thus you protect the nerves of diabetic patients].
    MMW Fortschritte der Medizin, 2004, Jan-29, Volume: 146, Issue:5

    Topics: Administration, Oral; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Melli

2004
Comparative in vitro uptake of zinc by erythrocytes of normal vs Type 2 diabetic individuals and the associated factors.
    Diabetes, nutrition & metabolism, 2004, Volume: 17, Issue:6

    Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Blood Glucose; Ceruloplasmin; Diabetes Mellitus, Type 2; E

2004
Evaluating thiamine deficiency in patients with diabetes.
    Diabetes & vascular disease research, 2006, Volume: 3, Issue:2

    Topics: Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Male; Mi

2006
Adiponectin decreases postprandially following a heat-processed meal in individuals with type 2 diabetes: an effect prevented by benfotiamine and cooking method.
    Diabetes care, 2007, Volume: 30, Issue:10

    Topics: Adiponectin; Analysis of Variance; Body Mass Index; Chelating Agents; Cooking; Diabetes Mellitus, Ty

2007
High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease.
    Diabetologia, 2007, Volume: 50, Issue:10

    Topics: Albuminuria; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies

2007
[Patients with type-II diabetes mellitus and neuropathy have no deficiency of vitamins A, E, beta-carotene, B1, B2, B6, B12 and folic acid].
    Medizinische Klinik (Munich, Germany : 1983), 1993, Aug-15, Volume: 88, Issue:8

    Topics: Aged; Avitaminosis; beta Carotene; Carotenoids; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Fe

1993