thiamine has been researched along with Diabetes Mellitus, Type 2 in 52 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "During weight loss, erythrocyte thiamine pyrophosphate (TPP) decreased (221±52 to 195±39 nmol/L, P<0." | 9.16 | Increased thiamine intake may be required to maintain thiamine status during weight loss in patients with type 2 diabetes. ( Brinkworth, GD; Cleanthous, X; Clifton, PM; Keogh, JB; Noakes, M; Wycherley, TP, 2012) |
| "High-dose supplements of thiamine prevent the development of microalbuminuria in experimental diabetes." | 9.14 | High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. ( Akhtar, MW; Alam, SS; Larkin, JR; Rabbani, N; Riaz, S; Shafi, T; Thornalley, PJ, 2009) |
| " The diabetic states that associate with these genetic variants are MODY 2, thiamine responsive anaemia syndrome (TRAS) and mitochondrial diabetes." | 8.81 | Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology? ( Maassen, JA, 2002) |
| " We herein report a case of cardiac dysfunction due to thiamine deficiency after hemodialysis in a patient with suspected biguanide-related lactic acidosis." | 8.12 | Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis. ( Jimura, F; Kachi, N; Tamaki, H; Tsushima, H, 2022) |
| "The present study aimed to determine thiamine intake levels and the association between thiamine intake, diabetes, cardiovascular diseases and mental health." | 8.02 | Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study. ( Duc, HN; Kim, MS; Oh, H; Yoon, IM, 2021) |
| " We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency." | 7.85 | The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation. ( Fujita, M; Godo, S; Kudo, D; Kushimoto, S; Nomura, R; Shimokawa, H; Yoshida, Y, 2017) |
| "Thiamine is a coenzyme important in intracellular glucose metabolism." | 6.72 | Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. ( Abularrage, CJ; Arora, S; Kellicut, D; Lidor, A; Nylen, E; Sidawy, AN; Weiswasser, JM, 2006) |
| "Thiamine deficiency has been linked to microvascular complications in patients with diabetes mellitus (DM)." | 5.38 | Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria. ( Abd-Alrahman, SH; Al-Attas, OS; Al-Daghri, NM; Alfadda, AA; Sabico, S, 2012) |
| "Wolfram syndrome, Kearns-Sayre syndrome, thiamine-responsive megaloblastic anemia, and maternally inherited diabetes and deafness are genetic disorders characterized by diabetes, impaired hearing, and vision." | 5.22 | Diabetes Out-of-the-Box: Diabetes Mellitus and Impairment in Hearing and Vision. ( Gruber, N; Pinhas-Hamiel, O, 2022) |
| "Twelve hyperglycemic subjects (10 cases of impaired glucose tolerance and 2 new cases of type 2 diabetes) completed this randomized, double-blind trial, where all participants received both placebo and thiamine capsules (3 × 100 mg/day) for 6 weeks in a cross-over manner." | 5.17 | High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial. ( Alaei Shahmiri, F; Sherriff, J; Soares, MJ; Zhao, Y, 2013) |
| "During weight loss, erythrocyte thiamine pyrophosphate (TPP) decreased (221±52 to 195±39 nmol/L, P<0." | 5.16 | Increased thiamine intake may be required to maintain thiamine status during weight loss in patients with type 2 diabetes. ( Brinkworth, GD; Cleanthous, X; Clifton, PM; Keogh, JB; Noakes, M; Wycherley, TP, 2012) |
| "High-dose supplements of thiamine prevent the development of microalbuminuria in experimental diabetes." | 5.14 | High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. ( Akhtar, MW; Alam, SS; Larkin, JR; Rabbani, N; Riaz, S; Shafi, T; Thornalley, PJ, 2009) |
| " The diabetic states that associate with these genetic variants are MODY 2, thiamine responsive anaemia syndrome (TRAS) and mitochondrial diabetes." | 4.81 | Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology? ( Maassen, JA, 2002) |
| " We herein report a case of cardiac dysfunction due to thiamine deficiency after hemodialysis in a patient with suspected biguanide-related lactic acidosis." | 4.12 | Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis. ( Jimura, F; Kachi, N; Tamaki, H; Tsushima, H, 2022) |
| "The present study aimed to determine thiamine intake levels and the association between thiamine intake, diabetes, cardiovascular diseases and mental health." | 4.02 | Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study. ( Duc, HN; Kim, MS; Oh, H; Yoon, IM, 2021) |
| " We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency." | 3.85 | The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation. ( Fujita, M; Godo, S; Kudo, D; Kushimoto, S; Nomura, R; Shimokawa, H; Yoshida, Y, 2017) |
| " Currently, there are only few pathogenetically oriented pharmacotherapies for DSPN, one of which is benfotiamine, a prodrug of thiamine with a high bioavailability and favourable safety profile." | 3.11 | BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy. ( Al-Hasani, H; Bönhof, GJ; Herder, C; Icks, A; Knebel, B; Kuss, O; Reule, C; Roden, M; Sipola, G; Strassburger, K; Strom, A; Wollmann, JC; Ziegler, D, 2022) |
| "In people with Type 2 diabetes and markedly impaired fasting flow-mediated dilatation, a mixed test meal does not further deteriorate flow-mediated dilatation or variables of microvascular or autonomic nervous function." | 2.78 | A randomized, double-blind, crossover, placebo-controlled trial of 6 weeks benfotiamine treatment on postprandial vascular function and variables of autonomic nerve function in Type 2 diabetes. ( Pop, A; Stirban, A; Tschoepe, D, 2013) |
| "Patients with type 2 diabetes and urinary albumin excretion in the high-normal and microalbuminuric range (15-300 mg/24h) were randomized to receive benfotiamine (n = 39) or placebo (n = 43)." | 2.77 | Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy. ( Alkhalaf, A; Bakker, SJ; Bilo, HJ; Gans, RO; Groenier, KH; Heeringa, P; Kleefstra, N; Navis, GJ; Schalkwijk, CG; Scheijen, JL, 2012) |
| "Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to 12 weeks of benfotiamine (900 mg/day) (n = 39) or placebo (n = 43)." | 2.75 | A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy. ( Achenbach, U; Alkhalaf, A; Bakker, SJ; Bilo, HJ; Gans, RO; Kleefstra, N; Klooster, A; Mijnhout, GS; Navis, GJ; Slingerland, RJ; van Oeveren, W, 2010) |
| "165 patients with symmetrical, distal diabetic polyneuropathy were randomised to one of three treatment groups entering the wash-out phase and 133/124 patients were analysed in the ITT/PP analysis: Benfotiamine 600 mg per day (n=47/43), benfotiamine 300 mg per day (n=45/42) or placebo (n=41/39)." | 2.73 | Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. ( Achenbach, U; Bretzel, RG; Federlin, K; Gaus, W; Stracke, H, 2008) |
| "Thiamine is a coenzyme important in intracellular glucose metabolism." | 2.72 | Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia. ( Abularrage, CJ; Arora, S; Kellicut, D; Lidor, A; Nylen, E; Sidawy, AN; Weiswasser, JM, 2006) |
| "Thirteen people with type 2 diabetes were given a heat-processed test meal with a high AGE content (HAGE; 15." | 2.72 | Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. ( Gawlowski, T; Götting, C; Horstmann, T; Kleesiek, K; Koschinsky, T; Mueller-Roesel, M; Negrean, M; Stirban, A; Stratmann, B; Tschoepe, D; Uribarri, J; Vlassara, H, 2006) |
| "Type 2 diabetes was defined as a fasting serum HbA1c level of 6." | 1.72 | Associations between Adherence to the Taiwan Dietary Reference Intakes of Micronutrients and the Risk of Type 2 Diabetes. ( Li, MC, 2022) |
| "Thiamine deficiency was highly prevalent in all groups, whereas low vitamin B₁₂ and elevated methylmalonic acid were rare." | 1.42 | Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. ( Bangert, V; Hostalek, U; Kaiser, RP; Nix, WA; Obeid, R; Schilling, M; Zirwes, R, 2015) |
| "A 59-year-old man with type 2 diabetes mellitus (without treatment two weeks before the intoxication) intentionally ingested a substantial amount of ethanol along with ~750 mL of laminate floor cleaner containing citric acid." | 1.40 | Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake. ( Beijnen, JH; Brandjes, DP; Daling, R; Hendrikx, JJ; Hooijberg, JH; Huitema, AD; Lagas, JS; Schellens, JH, 2014) |
| "Thiamine deficiency has been linked to microvascular complications in patients with diabetes mellitus (DM)." | 1.38 | Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria. ( Abd-Alrahman, SH; Al-Attas, OS; Al-Daghri, NM; Alfadda, AA; Sabico, S, 2012) |
| "One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited." | 1.38 | Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation. ( Adaikalakoteswari, A; Adam, JM; Kariadi, SH; Rabbani, N; Thornalley, PJ; Tjokroprawiro, A; Waspadji, S, 2012) |
| "The presence of Wernicke encephalopathy in alcoholics with diabetic ketoacidosis, suggests that metabolic decompensation is essential in the onset of the disease." | 1.35 | Wernicke encephalopathy in alcoholics with diabetic ketoacidosis. ( Chamorro, AJ; Garcia-Diez, LC; Luna, G; Marcos-Martin, M; Martin-Polo, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (3.85) | 18.2507 |
| 2000's | 17 (32.69) | 29.6817 |
| 2010's | 25 (48.08) | 24.3611 |
| 2020's | 8 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Bönhof, GJ | 1 |
| Sipola, G | 1 |
| Strom, A | 1 |
| Herder, C | 1 |
| Strassburger, K | 1 |
| Knebel, B | 1 |
| Reule, C | 1 |
| Wollmann, JC | 1 |
| Icks, A | 1 |
| Al-Hasani, H | 1 |
| Roden, M | 1 |
| Kuss, O | 1 |
| Ziegler, D | 1 |
| Tamaki, H | 1 |
| Tsushima, H | 1 |
| Kachi, N | 1 |
| Jimura, F | 1 |
| Zheng, Y | 1 |
| Xu, Z | 1 |
| Chen, X | 1 |
| Ma, W | 1 |
| Cai, J | 1 |
| Ma, A | 1 |
| Gruber, N | 1 |
| Pinhas-Hamiel, O | 1 |
| Li, MC | 1 |
| Wang, L | 1 |
| Yang, C | 1 |
| Song, F | 1 |
| Liu, Z | 1 |
| Liu, S | 1 |
| Piuri, G | 1 |
| Zocchi, M | 1 |
| Della Porta, M | 1 |
| Ficara, V | 1 |
| Manoni, M | 1 |
| Zuccotti, GV | 1 |
| Pinotti, L | 1 |
| Maier, JA | 1 |
| Cazzola, R | 1 |
| Duc, HN | 1 |
| Oh, H | 1 |
| Yoon, IM | 1 |
| Kim, MS | 1 |
| Chalásová, K | 1 |
| Pácal, L | 1 |
| Pleskačová, A | 1 |
| Knopfová, L | 1 |
| Řehořová, J | 1 |
| Tomandlová, M | 1 |
| Tomandl, J | 1 |
| Kaňková, K | 1 |
| Liang, X | 1 |
| Yee, SW | 1 |
| Chien, HC | 1 |
| Chen, EC | 1 |
| Luo, Q | 1 |
| Zou, L | 1 |
| Piao, M | 1 |
| Mifune, A | 1 |
| Chen, L | 1 |
| Calvert, ME | 1 |
| King, S | 1 |
| Norheim, F | 1 |
| Abad, J | 1 |
| Krauss, RM | 1 |
| Giacomini, KM | 1 |
| Karkabounas, S | 1 |
| Papadopoulos, N | 1 |
| Anastasiadou, C | 1 |
| Gubili, C | 1 |
| Peschos, D | 1 |
| Daskalou, T | 1 |
| Fikioris, N | 1 |
| Simos, YV | 1 |
| Kontargiris, E | 1 |
| Gianakopoulos, X | 1 |
| Ragos, V | 1 |
| Chatzidimitriou, M | 1 |
| Stirban, A | 5 |
| Pop, A | 2 |
| Tschoepe, D | 4 |
| Alaei Shahmiri, F | 1 |
| Soares, MJ | 1 |
| Zhao, Y | 1 |
| Sherriff, J | 1 |
| Chen, Z | 1 |
| Zhong, C | 1 |
| Fischer, A | 1 |
| Heckermann, S | 1 |
| Sergienko, VA | 1 |
| Segin, VB | 1 |
| Samir, A | 1 |
| Sergienko, AA | 1 |
| Hendrikx, JJ | 1 |
| Lagas, JS | 1 |
| Daling, R | 1 |
| Hooijberg, JH | 1 |
| Schellens, JH | 1 |
| Beijnen, JH | 1 |
| Brandjes, DP | 1 |
| Huitema, AD | 1 |
| Nix, WA | 1 |
| Zirwes, R | 1 |
| Bangert, V | 1 |
| Kaiser, RP | 1 |
| Schilling, M | 1 |
| Hostalek, U | 1 |
| Obeid, R | 1 |
| Ruiz Bajo, B | 1 |
| Moreno García, MP | 1 |
| Rueda Mena, E | 1 |
| González Chinchón, G | 1 |
| Riaz, S | 3 |
| Luo, G | 1 |
| He, J | 1 |
| Wu, T | 1 |
| Huang, Y | 1 |
| Miao, Z | 1 |
| Zhao, Z | 1 |
| Wang, X | 1 |
| Wang, Y | 1 |
| Godo, S | 1 |
| Yoshida, Y | 1 |
| Fujita, M | 1 |
| Kudo, D | 1 |
| Nomura, R | 1 |
| Shimokawa, H | 1 |
| Kushimoto, S | 1 |
| Vindedzis, SA | 1 |
| Stanton, KG | 1 |
| Sherriff, JL | 1 |
| Dhaliwal, SS | 1 |
| Wong, CY | 1 |
| Qiuwaxi, J | 1 |
| Chen, H | 1 |
| Li, SW | 1 |
| Chan, HT | 1 |
| Tam, S | 1 |
| Shu, XO | 1 |
| Lau, CP | 1 |
| Kwong, YL | 1 |
| Tse, HF | 1 |
| Rabbani, N | 4 |
| Alam, SS | 1 |
| Larkin, JR | 1 |
| Akhtar, MW | 1 |
| Shafi, T | 1 |
| Thornalley, PJ | 4 |
| Alkhalaf, A | 3 |
| Kleefstra, N | 3 |
| Groenier, KH | 2 |
| Bakker, SJ | 3 |
| Navis, GJ | 3 |
| Bilo, HJ | 3 |
| Chamorro, AJ | 1 |
| Marcos-Martin, M | 1 |
| Martin-Polo, J | 1 |
| Garcia-Diez, LC | 1 |
| Luna, G | 1 |
| Klooster, A | 1 |
| van Oeveren, W | 1 |
| Achenbach, U | 2 |
| Slingerland, RJ | 1 |
| Mijnhout, GS | 1 |
| Gans, RO | 2 |
| González-Ortiz, M | 1 |
| Martínez-Abundis, E | 1 |
| Robles-Cervantes, JA | 1 |
| Ramírez-Ramírez, V | 1 |
| Ramos-Zavala, MG | 1 |
| Skinner, V | 1 |
| Srai, SK | 1 |
| Al-Attas, OS | 1 |
| Al-Daghri, NM | 1 |
| Alfadda, AA | 1 |
| Abd-Alrahman, SH | 1 |
| Sabico, S | 1 |
| Adaikalakoteswari, A | 1 |
| Waspadji, S | 1 |
| Tjokroprawiro, A | 1 |
| Kariadi, SH | 1 |
| Adam, JM | 1 |
| Polizzi, FC | 1 |
| Andican, G | 2 |
| Çetin, E | 2 |
| Civelek, S | 2 |
| Yumuk, V | 2 |
| Burçak, G | 2 |
| Heeringa, P | 1 |
| Scheijen, JL | 1 |
| Schalkwijk, CG | 2 |
| Keogh, JB | 1 |
| Cleanthous, X | 1 |
| Wycherley, TP | 1 |
| Brinkworth, GD | 1 |
| Noakes, M | 1 |
| Clifton, PM | 1 |
| Engelen, L | 1 |
| Stehouwer, CD | 1 |
| Candan Polizzi, F | 1 |
| Maassen, JA | 1 |
| Muroyama, K | 1 |
| Murosaki, S | 1 |
| Yamamoto, Y | 1 |
| Odaka, H | 1 |
| Chung, HC | 1 |
| Miyoshi, M | 1 |
| Haupt, E | 1 |
| Ledermann, H | 1 |
| Köpcke, W | 1 |
| Agte, VV | 1 |
| Nagmote, RV | 1 |
| Tarwadi, KV | 1 |
| Arora, S | 1 |
| Lidor, A | 1 |
| Abularrage, CJ | 1 |
| Weiswasser, JM | 1 |
| Nylen, E | 1 |
| Kellicut, D | 1 |
| Sidawy, AN | 1 |
| Negrean, M | 2 |
| Stratmann, B | 2 |
| Gawlowski, T | 1 |
| Horstmann, T | 1 |
| Götting, C | 2 |
| Kleesiek, K | 2 |
| Mueller-Roesel, M | 1 |
| Koschinsky, T | 1 |
| Uribarri, J | 1 |
| Vlassara, H | 1 |
| Jermendy, G | 1 |
| Salomon, J | 1 |
| Babaei-Jadidi, R | 1 |
| Al Ali, H | 1 |
| Antonysunil, A | 1 |
| Larkin, J | 1 |
| Ahmed, A | 1 |
| Rayman, G | 1 |
| Bodmer, CW | 1 |
| Stracke, H | 1 |
| Gaus, W | 1 |
| Federlin, K | 1 |
| Bretzel, RG | 1 |
| Straub, RH | 1 |
| Rokitzki, L | 1 |
| Schumacher, T | 1 |
| Hillmann, C | 1 |
| Palitzsch, KD | 1 |
| Schölmerich, J | 1 |
| Sadekov, RA | 1 |
| Danilov, AB | 1 |
| Veĭn, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Serum Magnesium Level in Type 2 Diabetes Mellitus[NCT06059833] | 120 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| Effect of Thiamine on Serum Glucagon And Reactive Oxygen Species (ROS) in Perioperative Stress Response[NCT05663164] | 30 participants (Actual) | Interventional | 2022-10-01 | Completed | |||
| Pirofosfato de Tiamina Como Coadyuvante de la Metformina en el Tratamiento de Pacientes Con Diabetes Mellitus Tipo 2[NCT04053621] | 92 participants (Anticipated) | Interventional | 2021-01-31 | Not yet recruiting | |||
| The Vitamin B Status in Type 2 Diabetes (VITA) Study[NCT03447275] | 174 participants (Actual) | Observational | 2011-01-31 | Completed | |||
| A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318] | Phase 4 | 86 participants (Anticipated) | Interventional | 2007-12-31 | Completed | ||
| Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System[NCT00446810] | Phase 4 | 30 participants (Anticipated) | Interventional | 2007-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for thiamine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Diabetes Out-of-the-Box: Diabetes Mellitus and Impairment in Hearing and Vision.
Topics: Anemia, Megaloblastic; Deafness; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hearing; Hearing Loss | 2022 |
Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes.
Topics: Adult; Child; Diabetes Mellitus, Type 2; Dietary Supplements; Gastrointestinal Microbiome; Humans; M | 2021 |
Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies.
Topics: Alzheimer Disease; Biomarkers; Brain Chemistry; Diabetes Mellitus, Type 2; Glucose; Glucose Transpor | 2013 |
Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1.
Topics: Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Gene Expression | 2015 |
Drugs for the treatment of diabetes complications. Zycose: a new player in the field?
Topics: 4-Aminobenzoic Acid; Animals; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus, T | 2008 |
Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2011 |
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2013 |
Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology?
Topics: Anemia, Megaloblastic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Mitochondrial Diseases; | 2002 |
18 trials available for thiamine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; Humans; Polyneuropathies; Qua | 2022 |
Effects of α-Lipoic Acid, Carnosine, and Thiamine Supplementation in Obese Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind Study.
Topics: Administration, Oral; Blood Glucose; Carnosine; Diabetes Mellitus, Type 2; Dietary Supplements; Doub | 2018 |
A randomized, double-blind, crossover, placebo-controlled trial of 6 weeks benfotiamine treatment on postprandial vascular function and variables of autonomic nerve function in Type 2 diabetes.
Topics: Adult; Aged; Antioxidants; Autonomic Pathways; Biomarkers; Blood Glucose; Cross-Over Studies; Diabet | 2013 |
High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial.
Topics: Adult; Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Supplements; Dose | 2013 |
Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence of benfotiamine treatment.
Topics: Adult; Aged; Chelating Agents; Cross-Over Studies; Diabetes Complications; Diabetes Mellitus, Type 2 | 2013 |
High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study.
Topics: Albuminuria; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Glomerular Filtration R | 2009 |
A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy.
Topics: Adjuvants, Immunologic; Adult; Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotens | 2010 |
Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes.
Topics: Adult; Aged; Biomarkers; Blood Glucose; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Cyto | 2011 |
Effect of high dose thiamine on the levels of urinary protein biomarkers in diabetes mellitus type 2.
Topics: Adult; Aged; Albuminuria; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type | 2011 |
Increased DNA-glycation in type 2 diabetic patients: the effect of thiamine and pyridoxine therapy.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; DNA; Female; Glycated Hemogl | 2012 |
Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy.
Topics: Aged; Biomarkers; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Endoth | 2012 |
Increased thiamine intake may be required to maintain thiamine status during weight loss in patients with type 2 diabetes.
Topics: Animals; Body Mass Index; Diabetes Mellitus, Type 2; Diet, Reducing; Dietary Proteins; Erythrocytes; | 2012 |
Plasma AGE-peptides and C-peptide in early-stage diabetic nephropathy patients on thiamine and pyridoxine therapy.
Topics: Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Diabetic Nephropathies | 2013 |
Benfotiamine in the treatment of diabetic polyneuropathy--a three-week randomized, controlled pilot study (BEDIP study).
Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 2005 |
Thiamine (vitamin B1) improves endothelium-dependent vasodilatation in the presence of hyperglycemia.
Topics: Adult; Aged; Blood Flow Velocity; Blood Glucose; Brachial Artery; Diabetes Mellitus, Type 2; Endothe | 2006 |
Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes.
Topics: Adjuvants, Immunologic; Biomarkers; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; En | 2006 |
Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study.
Topics: Adjuvants, Immunologic; Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic | 2008 |
[Diabetic polyneuropathy treatment by milgamma-100 preparation].
Topics: Adult; Chelating Agents; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Therapy, Combination | 1998 |
26 other studies available for thiamine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Cardiac Dysfunction Due to Thiamine Deficiency after Hemodialysis for Biguanide-related Lactic Acidosis.
Topics: Acidosis, Lactic; Beriberi; Biguanides; Diabetes Mellitus, Type 2; Heart Diseases; Humans; Hypoglyce | 2022 |
Thiamin and riboflavin status with related enzyme activities in pulmonary tuberculosis with diabetes mellitus in Shandong province of China.
Topics: China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Humans; Riboflavin; Riboflavin Deficiency | 2022 |
Associations between Adherence to the Taiwan Dietary Reference Intakes of Micronutrients and the Risk of Type 2 Diabetes.
Topics: Calcium; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diet; Female; Glycated Hemoglobin; Huma | 2022 |
Therapeutic Effectiveness of
Topics: Amino Acids; Animals; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Gardenia; Humans; Male; Meta | 2020 |
Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Child; Child, Preschool; Cross- | 2021 |
Transketolase Activity but not Thiamine Membrane Transport Change in Response to Hyperglycaemia and Kidney Dysfunction.
Topics: Adult; Aged; Biological Transport; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Erythrocytes; | 2018 |
Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
Topics: Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Diabete | 2018 |
[The effect of long-chain polyunsaturated higher ω-3 fatty acids, benfotiamine and α-lipoic acid on the lipid metabolism in patients with diabetes mellitus type 2 and cardiovascular autonomic neuropathy].
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; D | 2013 |
Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake.
Topics: Acidosis; Acidosis, Lactic; Alcoholic Intoxication; Citric Acid; Diabetes Mellitus, Type 2; Humans; | 2014 |
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.
Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Biomarkers; Case-Control Studies; Diabetes Mellitus, Ty | 2015 |
Atypical presentation of Wernicke syndrome with magnetic resonance imaging showing cerebellar involvement and no changes in typical regions.
Topics: Cerebellum; Diabetes Mellitus, Type 2; Female; Humans; Liver Diseases, Alcoholic; Magnetic Resonance | 2016 |
The Therapeutic Effect of Stellate Ganglion Block on Facial Nerve Palsy in Patients with Type 2 Diabetes Mellitus.
Topics: Adult; Anesthetics, Local; Antipyrine; Aspirin; Autonomic Nerve Block; Blood Glucose; Dexamethasone; | 2015 |
The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation.
Topics: Acidosis, Lactic; Aged; Biguanides; Diabetes Mellitus, Type 2; Dietary Supplements; Female; Humans; | 2017 |
Thiamine deficiency in diabetes - is diet relevant?
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diet; Dietary Supplements; Female | 2008 |
Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes.
Topics: Brachial Artery; Cell Count; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelial Cells; En | 2008 |
Thiamine in diabetic nephropathy: a novel treatment modality?
Topics: Albuminuria; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin; | 2009 |
Wernicke encephalopathy in alcoholics with diabetic ketoacidosis.
Topics: Aged; Alcoholism; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Humans; Insulin; Magnetic Resona | 2009 |
Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria.
Topics: Adolescent; Adult; Aged; Albuminuria; Blood Glucose; Child; Child, Preschool; Cholesterol; Chromatog | 2012 |
Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation.
Topics: Albuminuria; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Indonesia; In | 2012 |
Anti-obesity effects of a mixture of thiamin, arginine, caffeine, and citric acid in non-insulin dependent diabetic KK mice.
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Arginine; Caffeine; Citric Acid; Diabetes Mellitus, Ty | 2003 |
[Oral benfotiamine therapy. Thus you protect the nerves of diabetic patients].
Topics: Administration, Oral; Controlled Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Melli | 2004 |
Comparative in vitro uptake of zinc by erythrocytes of normal vs Type 2 diabetic individuals and the associated factors.
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Blood Glucose; Ceruloplasmin; Diabetes Mellitus, Type 2; E | 2004 |
Evaluating thiamine deficiency in patients with diabetes.
Topics: Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Male; Mi | 2006 |
Adiponectin decreases postprandially following a heat-processed meal in individuals with type 2 diabetes: an effect prevented by benfotiamine and cooking method.
Topics: Adiponectin; Analysis of Variance; Body Mass Index; Chelating Agents; Cooking; Diabetes Mellitus, Ty | 2007 |
High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease.
Topics: Albuminuria; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies | 2007 |
[Patients with type-II diabetes mellitus and neuropathy have no deficiency of vitamins A, E, beta-carotene, B1, B2, B6, B12 and folic acid].
Topics: Aged; Avitaminosis; beta Carotene; Carotenoids; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Fe | 1993 |