thiamine has been researched along with Depression in 19 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study aimed to determine thiamine intake levels and the association between thiamine intake, diabetes, cardiovascular diseases and mental health." | 8.02 | Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study. ( Duc, HN; Kim, MS; Oh, H; Yoon, IM, 2021) |
| "Severe alcoholism can be associated with significant nutritional and vitamin deficiency, especially vitamin B1 (thiamine) which is associated with neurological deficits impacting mood and cognition." | 5.20 | Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity. ( Butler, MG; Manzardo, AM; Pendleton, T; Penick, EC; Poje, A, 2015) |
| "The present study aimed to determine thiamine intake levels and the association between thiamine intake, diabetes, cardiovascular diseases and mental health." | 4.02 | Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study. ( Duc, HN; Kim, MS; Oh, H; Yoon, IM, 2021) |
| "Despite the absence of thiamine deficiency, whole blood thiamine was lower in patients with dementia and delirium compared to those without." | 3.91 | Blood Thiamine Level and Cognitive Function in Older Hospitalized Patients. ( Angersbach, B; Klimek, CN; Lueg, G; Pourhassan, M; Wirth, R, 2019) |
| "Thiamine has been hypothesized to play an important role in mental health; however, few studies have investigated the association between thiamine nutritional status and depression in the general population." | 3.79 | Thiamine nutritional status and depressive symptoms are inversely associated among older Chinese adults. ( Chen, H; Ding, H; Ke, Z; Li, H; Lin, X; Ye, X; Zhang, G, 2013) |
| " On the 20th day after the start of TD feeding, the increased duration of immobility time induced by TD was shortened by chronic administration of the tricyclic antidepressant imipramine (10 mg/kg, i." | 1.31 | Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice. ( Esashi, A; Hozumi, S; Kisara, K; Nakagawasai, O; Niijima, F; Tadano, T; Tan-No, K; Taniguchi, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 5 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, HD | 1 |
| Oh, H | 2 |
| Kim, MS | 2 |
| Ortí, JER | 1 |
| Cuerda-Ballester, M | 1 |
| Drehmer, E | 1 |
| Carrera-Juliá, S | 1 |
| Motos-Muñoz, M | 1 |
| Cunha-Pérez, C | 1 |
| Benlloch, M | 1 |
| López-Rodríguez, MM | 1 |
| Wu, Y | 2 |
| Zhang, L | 1 |
| Li, S | 3 |
| Zhang, D | 2 |
| Duc, HN | 1 |
| Yoon, IM | 1 |
| Wang, W | 1 |
| Pavlov, D | 2 |
| Markova, N | 1 |
| Bettendorff, L | 2 |
| Chekhonin, V | 1 |
| Pomytkin, I | 1 |
| Lioudyno, V | 1 |
| Svistunov, A | 1 |
| Ponomarev, E | 1 |
| Lesch, KP | 1 |
| Strekalova, T | 2 |
| Pourhassan, M | 1 |
| Angersbach, B | 1 |
| Lueg, G | 1 |
| Klimek, CN | 1 |
| Wirth, R | 1 |
| Gorlova, A | 1 |
| Anthony, DC | 1 |
| Ponomarev, ED | 1 |
| Sambon, M | 1 |
| Proshin, A | 1 |
| Shafarevich, I | 1 |
| Babaevskaya, D | 1 |
| Lesсh, KP | 1 |
| Manzardo, AM | 1 |
| Pendleton, T | 1 |
| Poje, A | 1 |
| Penick, EC | 1 |
| Butler, MG | 1 |
| Xiao, D | 1 |
| Meng, FH | 1 |
| Dai, W | 1 |
| Yong, Z | 1 |
| Liu, JQ | 1 |
| Zhou, XB | 1 |
| Endevelt, R | 1 |
| Lemberger, J | 1 |
| Bregman, J | 1 |
| Kowen, G | 1 |
| Berger-Fecht, I | 1 |
| Lander, H | 1 |
| Karpati, T | 1 |
| Shahar, DR | 1 |
| Nikseresht, S | 1 |
| Etebary, S | 1 |
| Karimian, M | 1 |
| Nabavizadeh, F | 1 |
| Zarrindast, MR | 1 |
| Sadeghipour, HR | 1 |
| Zhang, G | 1 |
| Ding, H | 1 |
| Chen, H | 1 |
| Ye, X | 1 |
| Li, H | 1 |
| Lin, X | 1 |
| Ke, Z | 1 |
| ACUNA, JC | 1 |
| Vendittelli, F | 1 |
| Alain, J | 1 |
| Nouaille, Y | 1 |
| Brosset, A | 1 |
| Tabaste, JL | 1 |
| Nakagawasai, O | 1 |
| Tadano, T | 1 |
| Hozumi, S | 1 |
| Taniguchi, R | 1 |
| Tan-No, K | 1 |
| Esashi, A | 1 |
| Niijima, F | 1 |
| Kisara, K | 1 |
| Anderson, KE | 1 |
| Bodansky, O | 1 |
| Kappas, A | 1 |
| Kellner, H | 1 |
| Gaudeau, S | 1 |
| Derrida, JP | 1 |
| Tillement, JP | 1 |
| Vernant, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effectiveness of Benfotiamine in Reducing Abusive Drinking Among Family History Positive and Negative Alcoholics[NCT00680121] | Phase 4 | 120 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The alcoholism severity scale measures the severity of a person's dependence to alcohol. The scale ranges from a score of 0 (least severe) to 33 (most severe). The higher the score the worse the dependence. (NCT00680121)
Timeframe: 6 Months
| Intervention | scores on a scale (Mean) |
|---|---|
| Control Group | 14.0 |
| Benfotiamine | 10.7 |
Scale measures impulsiveness. It includes 30 items that are scored to yield six first-order factors (attention, motor, self-control, cognitive complexity, perseverance, and cognitive instability impulsiveness) and three second-order factors (attentional, motor, and non-planning impulsiveness). Items are scored on a 4 point scale with 1 point equaling rarely/never up to 4 points equaling almost always/always. Total impulsivity score ranges from 30 (least impulsive) to 120 (most impulsive). The higher the score the higher the level of impulsiveness. (NCT00680121)
Timeframe: 6 Months
| Intervention | scores on a scale (Mean) |
|---|---|
| Control Group | 65.0 |
| Benfotiamine | 65.4 |
measured as standard drinks of alcohol per day (SD/day) (NCT00680121)
Timeframe: Change from Baseline to 6 Months
| Intervention | alcoholic drinks per day (Mean) |
|---|---|
| Control Group | -3.4 |
| Benfotiamine | -3.0 |
The SCL-90 is a brief multidimensional self-report inventory that screens for nine symptoms of psychopathology and provides three global distress indicators. It provides an overview of symptom severity and intensity. The outcome measures psychiatric symptoms using a 30-item scale reported as t-scores relative to a normative population. (NCT00680121)
Timeframe: 6 Months
| Intervention | t-score (Mean) |
|---|---|
| Control Group | 1.02 |
| Benfotiamine | 1.04 |
2 reviews available for thiamine and Depression
| Article | Year |
|---|---|
Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis.
Topics: Depression; Female; Folic Acid; Humans; Male; Observational Studies as Topic; Riboflavin; Thiamine; | 2022 |
Effects of oral contraceptives on vitamin metabolism.
Topics: Ascorbic Acid; Blood Platelets; Contraceptives, Oral; Depression; Female; Folic Acid; Humans; Leukoc | 1976 |
3 trials available for thiamine and Depression
| Article | Year |
|---|---|
Change in psychiatric symptomatology after benfotiamine treatment in males is related to lifetime alcoholism severity.
Topics: Adult; Alcoholism; Depression; Double-Blind Method; Humans; Male; Middle Aged; Psychiatric Status Ra | 2015 |
Intensive dietary intervention by a dietitian as a case manager among community dwelling older adults: the EDIT study.
Topics: Aged; Aged, 80 and over; Case Management; Cognition; Cognition Disorders; Depression; Dietary Carboh | 2011 |
[Treatment of cerebral degenerative symptoms due to age. Double blind trial on the effect of Juston (author's transl)].
Topics: Activities of Daily Living; Aged; Aging; Ascorbic Acid; Cachexia; Central Nervous System Diseases; D | 1975 |
14 other studies available for thiamine and Depression
| Article | Year |
|---|---|
Mixtures modeling identifies vitamin B1 and B3 intakes associated with depression.
Topics: Adult; Bayes Theorem; Cross-Sectional Studies; Depression; Humans; Thiamine; Vitamin B 12; Vitamins | 2022 |
Vitamin B1 Intake in Multiple Sclerosis Patients and its Impact on Depression Presence: A Pilot Study.
Topics: Adult; Cross-Sectional Studies; Depression; Diet; Dietary Carbohydrates; Dietary Supplements; Fast F | 2020 |
Association between levels of thiamine intake, diabetes, cardiovascular diseases and depression in Korea: a national cross-sectional study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Child; Child, Preschool; Cross- | 2021 |
Associations of dietary B vitamins intakes with depression in adults.
Topics: Adult; Depression; Eating; Female; Folic Acid; Humans; Male; Niacin; Nutrition Surveys; Riboflavin; | 2023 |
Elucidating the functions of brain GSK3α: Possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Glycogen Synthase Kinase | 2017 |
Blood Thiamine Level and Cognitive Function in Older Hospitalized Patients.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Cognition; Cognitive Dysfunction; Cross-Section | 2019 |
Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice.
Topics: Aggression; Animals; Antioxidants; Brain; Depression; Male; Mice, Inbred BALB C; Neuronal Plasticity | 2019 |
Design, Synthesis and Biological Evaluation of Brain-Targeted Thiamine Disulfide Prodrugs of Ampakine Compound LCX001.
Topics: Animals; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Depression; Mice; Opiate | 2016 |
Acute administration of Zn, Mg, and thiamine improves postpartum depression conditions in mice.
Topics: Animals; Anxiety; Behavior, Animal; Depression; Depression, Postpartum; Depressive Disorder, Major; | 2012 |
Thiamine nutritional status and depressive symptoms are inversely associated among older Chinese adults.
Topics: Aged; Aging; China; Cross-Sectional Studies; Depression; Erythrocytes; Female; Humans; Male; Middle | 2013 |
[THERAPEUTIC APPLICATIONS OF HYDROXOCOBALAMINE, THIAMINE AND PYRIDOXINE IN A CONJOINED FORM].
Topics: Anemia; Child; Depression; Depressive Disorder; Feeding and Eating Disorders; Geriatrics; Humans; Hy | 1963 |
A case of lipomeningocele reported with fluoxetine (and alprazolam, vitamins B1 and B6, heptaminol) prescribed during pregnancy.
Topics: Adult; Alprazolam; Depression; Drug Therapy, Combination; Female; Fluoxetine; Heptaminol; Humans; In | 1995 |
Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Weight; Depression; Diet; Disease | 2001 |
[A case of myocardiopathy with hypothiaminemia exacerbated by imiparmine].
Topics: Cardiomyopathies; Depression; Electrocardiography; Female; Humans; Imipramine; Middle Aged; Thiamine | 1976 |