thiamine has been researched along with Critical Illness in 40 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis." | 9.41 | Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. ( Bernard, GR; Brown, SM; Buchman, TG; Busse, LW; Coopersmith, CM; DeWilde, C; Ely, EW; Eyzaguirre, LM; Fowler, AA; Gaieski, DF; Gong, MN; Hager, DN; Hall, A; Hinson, JS; Hooper, MH; Kelen, GD; Khan, A; Levine, MA; Lewis, RJ; Lindsell, CJ; Marlin, JS; Martin, GS; McGlothlin, A; Moore, BL; Nugent, KL; Nwosu, S; Polito, CC; Rice, TW; Ricketts, EP; Rothman, RE; Rudolph, CC; Sanfilippo, F; Sevransky, JE; Viele, K; Wright, DW, 2021) |
| "In critically ill enterally-fed patients who developed hypophosphatemia, intravenous thiamine did not cause measurable differences in blood lactate or clinical outcomes." | 9.41 | A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial). ( Ali Abdelhamid, Y; Bellomo, R; Byrne, KM; Clancy, A; Collie, JT; Deane, AM; Douglas, JS; Fetterplace, K; Finnis, ME; Fujii, T; Greaves, R; Jiang, A; Maiden, MJ; Nichol, A; Plummer, MP; Russo, G; Tascone, B; Udy, AA; Yanase, F; Young, M, 2021) |
| "gov databases were searched using relevant keywords that focus on the use of thiamine to prevent or treat delirium in critically ill patients." | 9.12 | Delirium in Critical Illness Patients and the Potential Role of Thiamine Therapy in Prevention and Treatment: Findings from a Scoping Review with Implications for Evidence-Based Practice. ( Friganovic, A; Krupa, S; Lange, S; Mędrzycka-Dąbrowska, W; Oomen, B, 2021) |
| "To compare the prevalence of delirium among ICU patients who received thiamine with those who did not and to compare morbidity and mortality." | 8.31 | Thiamine Administration and the Prevalence of Delirium in the Intensive Care Unit: A Retrospective Before and After Interventional Study. ( Dana, E; Dichtwald, S; Fredman, B; Ifrach, N; Varbarbut, N; Zohar, E, 2023) |
| "To describe thiamine supplementation incidence in patients with AUD and various critical illnesses (alcohol withdrawal, septic shock, traumatic brain injury [TBI], and diabetic ketoacidosis [DKA]) in the United States." | 8.12 | Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study. ( Balaji, L; Berg, KM; Donnino, MW; Grossestreuer, AV; Holmberg, MJ; Issa, MS; Kronen, R; Moskowitz, A; Patel, PV; Pawar, RD; Thompson, G, 2022) |
| "To determine the prevalence and time course of thiamine deficiency (TD) in PICU patients." | 8.12 | Prevalence and Time Course of Thiamine Deficiency in Critically Ill Children: A Multicenter, Prospective Cohort Study in Turkey. ( Akkuzu, E; Bayrakci, B; Kalkan, G; Kendirli, T; Ozcan, S; Pasaoglu, H; Sincar, S; Yavuz, S, 2022) |
| "This review will provide evidence for the effectiveness of parental thiamine in the prevention or treatment of delirium in critical care." | 7.96 | Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol. ( Blackwood, B; McAuley, DF; McKenzie, CA; Ostermann, M; Page, VJ; Spronk, PE; Strain, WD; Taylor, D, 2020) |
| "The 3 cases demonstrated the rapidity of the reversal of severe thiamine deficiency, achieved by appropriate replacement in different hospitalized patients." | 7.81 | Rapid reversal of severe lactic acidosis after thiamine administration in critically ill adults: a report of 3 cases. ( Abramo, A; Forfori, F; Giacalone, M; Giunta, F; Iacconi, P; Martinelli, R; Pavoni, V; Rubino, A, 2015) |
| " We also identified a potential association between thiamine levels and lactic acidosis in patients without significant liver injury." | 7.76 | Thiamine deficiency in critically ill patients with sepsis. ( Barbash, I; Carney, E; Chase, M; Chou, PP; Cocchi, MN; Donnino, MW; Joyce, N; Ngo, L, 2010) |
| " Administration of a single 200-mg dose of intravenous thiamine achieved supraphysiological concentrations of thiamine pyrophosphate, with repeated dosing sustaining this effect." | 7.30 | Relationship of blood thiamine pyrophosphate to plasma phosphate and the response to enteral nutrition plus co-administration of intravenous thiamine during critical illness. ( Abdelhamid, YA; Ankravs, M; Bellomo, R; Byrne, KM; Clancy, A; Collie, JTB; Deane, AM; Finnis, ME; Greaves, R; Jiang, A; Tascone, B, 2023) |
| " Our examination of the most up-to-date evidence concludes that Recommended Daily Allowance supplementation is relatively safe for thiamine-deficient patients." | 7.01 | Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy. ( Hardy, G; Manzanares, W; Novoa, J, 2023) |
| " However, many questions remain regarding the optimal dosing regimens and plasma concentrations, timing of administration, and adverse effects of vitamin C and thiamine." | 6.66 | Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir. ( Halpern, NA; Obi, J; Pastores, SM; Ramanathan, LV; Yang, J, 2020) |
| "Dogs with critical illness had nonseptic (n = 24) or septic (n = 13) etiologies." | 5.72 | Evaluation of blood thiamine concentration in hospitalized dogs with and without critical illness. ( Brainard, BM; Dowgos, NM; Lane, SL, 2022) |
| "In critically ill enterally-fed patients who developed hypophosphatemia, intravenous thiamine did not cause measurable differences in blood lactate or clinical outcomes." | 5.41 | A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial). ( Ali Abdelhamid, Y; Bellomo, R; Byrne, KM; Clancy, A; Collie, JT; Deane, AM; Douglas, JS; Fetterplace, K; Finnis, ME; Fujii, T; Greaves, R; Jiang, A; Maiden, MJ; Nichol, A; Plummer, MP; Russo, G; Tascone, B; Udy, AA; Yanase, F; Young, M, 2021) |
| "To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis." | 5.41 | Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. ( Bernard, GR; Brown, SM; Buchman, TG; Busse, LW; Coopersmith, CM; DeWilde, C; Ely, EW; Eyzaguirre, LM; Fowler, AA; Gaieski, DF; Gong, MN; Hager, DN; Hall, A; Hinson, JS; Hooper, MH; Kelen, GD; Khan, A; Levine, MA; Lewis, RJ; Lindsell, CJ; Marlin, JS; Martin, GS; McGlothlin, A; Moore, BL; Nugent, KL; Nwosu, S; Polito, CC; Rice, TW; Ricketts, EP; Rothman, RE; Rudolph, CC; Sanfilippo, F; Sevransky, JE; Viele, K; Wright, DW, 2021) |
| "Sepsis trials examined 6 g/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone." | 5.22 | Update on vitamin C administration in critical illness. ( Bellomo, R; Fujii, T; Lankadeva, YR, 2022) |
| "gov databases were searched using relevant keywords that focus on the use of thiamine to prevent or treat delirium in critically ill patients." | 5.12 | Delirium in Critical Illness Patients and the Potential Role of Thiamine Therapy in Prevention and Treatment: Findings from a Scoping Review with Implications for Evidence-Based Practice. ( Friganovic, A; Krupa, S; Lange, S; Mędrzycka-Dąbrowska, W; Oomen, B, 2021) |
| " In clinical settings, high-dose selenium administration in sepsis has been disappointing." | 5.05 | Do micronutrient deficiencies contribute to mitochondrial failure in critical illness? ( Berger, MM, 2020) |
| "Thiamine has a crucial role in energy production, and consequently thiamine deficiency (TD) has been associated with cardiac failure, neurological disorders, oxidative stress (lactic acidosis and sepsis) and refeeding syndrome (RFS)." | 4.95 | Vitamin B1 in critically ill patients: needs and challenges. ( Bellomo, R; Collie, JTB; Eastwood, GM; Greaves, RF; Jones, OAH; Lam, Q, 2017) |
| "To compare the prevalence of delirium among ICU patients who received thiamine with those who did not and to compare morbidity and mortality." | 4.31 | Thiamine Administration and the Prevalence of Delirium in the Intensive Care Unit: A Retrospective Before and After Interventional Study. ( Dana, E; Dichtwald, S; Fredman, B; Ifrach, N; Varbarbut, N; Zohar, E, 2023) |
| "To determine the prevalence and time course of thiamine deficiency (TD) in PICU patients." | 4.12 | Prevalence and Time Course of Thiamine Deficiency in Critically Ill Children: A Multicenter, Prospective Cohort Study in Turkey. ( Akkuzu, E; Bayrakci, B; Kalkan, G; Kendirli, T; Ozcan, S; Pasaoglu, H; Sincar, S; Yavuz, S, 2022) |
| "To describe thiamine supplementation incidence in patients with AUD and various critical illnesses (alcohol withdrawal, septic shock, traumatic brain injury [TBI], and diabetic ketoacidosis [DKA]) in the United States." | 4.12 | Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study. ( Balaji, L; Berg, KM; Donnino, MW; Grossestreuer, AV; Holmberg, MJ; Issa, MS; Kronen, R; Moskowitz, A; Patel, PV; Pawar, RD; Thompson, G, 2022) |
| "This review will provide evidence for the effectiveness of parental thiamine in the prevention or treatment of delirium in critical care." | 3.96 | Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol. ( Blackwood, B; McAuley, DF; McKenzie, CA; Ostermann, M; Page, VJ; Spronk, PE; Strain, WD; Taylor, D, 2020) |
| "Thiamine deficiency was detected in 61 patients within the first 10 d of ICU stay, 57 cases being diagnosed on admission and 4 new cases on the 5th d." | 3.88 | Effect of blood thiamine concentrations on mortality: Influence of nutritional status. ( de Lima, LFP; Leite, HP; Paes, ÂT; Taddei, JAAC, 2018) |
| "Intensive insulin therapy does not appear to cause or worsen thiamine deficiency." | 3.85 | Thiamine Levels During Intensive Insulin Therapy in Critically Ill Patients. ( de Vos, R; Hofhuis, JGM; Kamphuis, S; Reijnders, MGJ; Spronk, PE; van Snippenburg, W, 2017) |
| "The 3 cases demonstrated the rapidity of the reversal of severe thiamine deficiency, achieved by appropriate replacement in different hospitalized patients." | 3.81 | Rapid reversal of severe lactic acidosis after thiamine administration in critically ill adults: a report of 3 cases. ( Abramo, A; Forfori, F; Giacalone, M; Giunta, F; Iacconi, P; Martinelli, R; Pavoni, V; Rubino, A, 2015) |
| " We also identified a potential association between thiamine levels and lactic acidosis in patients without significant liver injury." | 3.76 | Thiamine deficiency in critically ill patients with sepsis. ( Barbash, I; Carney, E; Chase, M; Chou, PP; Cocchi, MN; Donnino, MW; Joyce, N; Ngo, L, 2010) |
| " Our examination of the most up-to-date evidence concludes that Recommended Daily Allowance supplementation is relatively safe for thiamine-deficient patients." | 3.01 | Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy. ( Hardy, G; Manzanares, W; Novoa, J, 2023) |
| " However, many questions remain regarding the optimal dosing regimens and plasma concentrations, timing of administration, and adverse effects of vitamin C and thiamine." | 2.66 | Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir. ( Halpern, NA; Obi, J; Pastores, SM; Ramanathan, LV; Yang, J, 2020) |
| "However, refeeding hypophosphatemia is commonly encountered during critical illness." | 2.58 | Is refeeding syndrome relevant for critically ill patients? ( Koekkoek, WAC; Van Zanten, ARH, 2018) |
| "Sepsis is associated with an acute deficiency of vitamin C." | 2.58 | Vitamin C for the treatment of sepsis: The scientific rationale. ( Marik, PE, 2018) |
| "Dogs with critical illness had nonseptic (n = 24) or septic (n = 13) etiologies." | 1.72 | Evaluation of blood thiamine concentration in hospitalized dogs with and without critical illness. ( Brainard, BM; Dowgos, NM; Lane, SL, 2022) |
| "Thiamine is a precursor of the essential coenzyme thiamine pyrophosphate required for glucose metabolism; it improves the immune system function and has shown to reduce the risk of several diseases." | 1.62 | Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study. ( Al Bekairy, AM; Al Dossari, M; Al Eidan, F; Al Ghamdi, G; Al Harbi, S; Al Jeraisy, M; Al Katheri, A; Al Muqrin, M; Al Qahtani, N; Al Sulaiman, K; Algarni, R; Alharbi, A; Aljuhani, O; Alshahrani, A; Vishwakarma, R, 2021) |
| "This retrospective study included 132 polytrauma patients admitted to the ICU-CA between January 2013 and December 2014." | 1.43 | Modulation of the Redox Expression and Inflammation Response in the Critically Ill Polytrauma Patient with Thoracic Injury. Statistical Correlations between Antioxidant Therapy. ( Bedreag, OH; Cradigati, CA; Dumache, R; Horhat, FG; Luca, L; Papurica, M; Popovici, SE; Rogobete, AF; Sandesc, D; Sarandan, M; Sima, LV; Vernic, C, 2016) |
| "An 11-year-old male with autism became less responsive and was hospitalized with hepatomegaly and liver dysfunction, as well as severe lactic acidosis." | 1.42 | Vitamin B deficiencies in a critically ill autistic child with a restricted diet. ( Baird, JS; Ravindranath, TM, 2015) |
| "Thiamine plays a fundamental role in cellular metabolism." | 1.42 | Shoshin Beriberi in Critically-Ill patients: case series. ( Dabar, G; Habr, B; Harmouche, C; Jaber, B; Riachi, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.50) | 29.6817 |
| 2010's | 20 (50.00) | 24.3611 |
| 2020's | 19 (47.50) | 2.80 |
| Authors | Studies |
|---|---|
| Breik, L | 1 |
| Tatucu-Babet, OA | 1 |
| Ridley, EJ | 1 |
| Pawar, RD | 1 |
| Balaji, L | 1 |
| Grossestreuer, AV | 1 |
| Thompson, G | 1 |
| Holmberg, MJ | 1 |
| Issa, MS | 1 |
| Patel, PV | 1 |
| Kronen, R | 1 |
| Berg, KM | 2 |
| Moskowitz, A | 1 |
| Donnino, MW | 3 |
| Akkuzu, E | 1 |
| Yavuz, S | 1 |
| Ozcan, S | 1 |
| Sincar, S | 1 |
| Bayrakci, B | 1 |
| Kendirli, T | 1 |
| Pasaoglu, H | 1 |
| Kalkan, G | 1 |
| Fujii, T | 2 |
| Lankadeva, YR | 1 |
| Bellomo, R | 4 |
| Lane, SL | 1 |
| Dowgos, NM | 1 |
| Brainard, BM | 1 |
| Suárez-de-la-Rica, A | 3 |
| Croes, B | 3 |
| Ciudad, L | 3 |
| Vallejo, I | 3 |
| Mújica, J | 3 |
| Díaz-Almirón, M | 3 |
| Maseda, E | 3 |
| Novoa, J | 1 |
| Hardy, G | 1 |
| Manzanares, W | 1 |
| Collie, JTB | 2 |
| Jiang, A | 2 |
| Abdelhamid, YA | 1 |
| Ankravs, M | 1 |
| Byrne, KM | 2 |
| Clancy, A | 2 |
| Finnis, ME | 2 |
| Greaves, R | 2 |
| Tascone, B | 2 |
| Deane, AM | 2 |
| Dichtwald, S | 1 |
| Varbarbut, N | 1 |
| Dana, E | 1 |
| Zohar, E | 1 |
| Ifrach, N | 1 |
| Fredman, B | 1 |
| Berger, MM | 2 |
| Obi, J | 1 |
| Pastores, SM | 1 |
| Ramanathan, LV | 1 |
| Yang, J | 1 |
| Halpern, NA | 1 |
| McKenzie, CA | 1 |
| Page, VJ | 1 |
| Strain, WD | 1 |
| Blackwood, B | 1 |
| Ostermann, M | 1 |
| Taylor, D | 1 |
| Spronk, PE | 2 |
| McAuley, DF | 1 |
| Legouis, D | 1 |
| Ricksten, SE | 1 |
| Faivre, A | 1 |
| Verissimo, T | 1 |
| Gariani, K | 1 |
| Verney, C | 1 |
| Galichon, P | 1 |
| Berchtold, L | 1 |
| Feraille, E | 1 |
| Fernandez, M | 1 |
| Placier, S | 1 |
| Koppitch, K | 1 |
| Hertig, A | 1 |
| Martin, PY | 1 |
| Naesens, M | 1 |
| Pugin, J | 1 |
| McMahon, AP | 1 |
| Cippà, PE | 1 |
| de Seigneux, S | 1 |
| Maley, JH | 1 |
| Law, AC | 1 |
| Stevens, JP | 1 |
| Sevransky, JE | 1 |
| Rothman, RE | 1 |
| Hager, DN | 1 |
| Bernard, GR | 1 |
| Brown, SM | 1 |
| Buchman, TG | 1 |
| Busse, LW | 1 |
| Coopersmith, CM | 1 |
| DeWilde, C | 1 |
| Ely, EW | 1 |
| Eyzaguirre, LM | 1 |
| Fowler, AA | 1 |
| Gaieski, DF | 1 |
| Gong, MN | 1 |
| Hall, A | 1 |
| Hinson, JS | 1 |
| Hooper, MH | 1 |
| Kelen, GD | 1 |
| Khan, A | 1 |
| Levine, MA | 1 |
| Lewis, RJ | 1 |
| Lindsell, CJ | 1 |
| Marlin, JS | 1 |
| McGlothlin, A | 1 |
| Moore, BL | 1 |
| Nugent, KL | 1 |
| Nwosu, S | 1 |
| Polito, CC | 1 |
| Rice, TW | 1 |
| Ricketts, EP | 1 |
| Rudolph, CC | 1 |
| Sanfilippo, F | 1 |
| Viele, K | 1 |
| Martin, GS | 1 |
| Wright, DW | 1 |
| Sedhai, YR | 1 |
| Shrestha, DB | 1 |
| Budhathoki, P | 1 |
| Jha, V | 1 |
| Mandal, SK | 1 |
| Karki, S | 1 |
| Baniya, R | 1 |
| Cable, CA | 1 |
| Kashiouris, MG | 1 |
| Al Sulaiman, K | 1 |
| Aljuhani, O | 1 |
| Al Dossari, M | 1 |
| Alshahrani, A | 1 |
| Alharbi, A | 1 |
| Algarni, R | 1 |
| Al Jeraisy, M | 1 |
| Al Harbi, S | 1 |
| Al Katheri, A | 1 |
| Al Eidan, F | 1 |
| Al Bekairy, AM | 1 |
| Al Qahtani, N | 1 |
| Al Muqrin, M | 1 |
| Vishwakarma, R | 1 |
| Al Ghamdi, G | 1 |
| Collie, JT | 1 |
| Douglas, JS | 1 |
| Nichol, A | 1 |
| Udy, AA | 1 |
| Young, M | 1 |
| Russo, G | 1 |
| Fetterplace, K | 1 |
| Maiden, MJ | 1 |
| Plummer, MP | 1 |
| Yanase, F | 1 |
| Ali Abdelhamid, Y | 1 |
| Lange, S | 1 |
| Mędrzycka-Dąbrowska, W | 1 |
| Friganovic, A | 1 |
| Oomen, B | 1 |
| Krupa, S | 1 |
| Greaves, RF | 1 |
| Jones, OAH | 1 |
| Lam, Q | 1 |
| Eastwood, GM | 1 |
| Kamel, AY | 1 |
| Dave, NJ | 2 |
| Zhao, VM | 1 |
| Griffith, DP | 2 |
| Connor, MJ | 1 |
| Ziegler, TR | 2 |
| Hiffler, L | 1 |
| Adamolekun, B | 1 |
| Fischer, PR | 1 |
| Fattal-Vavleski, A | 1 |
| Koekkoek, WAC | 1 |
| Van Zanten, ARH | 1 |
| Leite, HP | 1 |
| de Lima, LFP | 1 |
| Taddei, JAAC | 1 |
| Paes, ÂT | 1 |
| Amrein, K | 1 |
| Oudemans-van Straaten, HM | 1 |
| Marik, PE | 1 |
| Woolum, JA | 1 |
| Abner, EL | 1 |
| Kelly, A | 1 |
| Thompson Bastin, ML | 1 |
| Morris, PE | 1 |
| Flannery, AH | 1 |
| Gundogan, K | 1 |
| Akbudak, IH | 1 |
| Bulut, K | 1 |
| Temel, S | 1 |
| Sungur, M | 1 |
| Guven, M | 1 |
| Carr, AC | 1 |
| Day, GS | 1 |
| del Campo, CM | 1 |
| Baird, JS | 1 |
| Ravindranath, TM | 1 |
| Gautam, S | 1 |
| Salciccioli, JD | 1 |
| Giberson, T | 1 |
| Saindon, B | 1 |
| Giacalone, M | 1 |
| Martinelli, R | 1 |
| Abramo, A | 1 |
| Rubino, A | 1 |
| Pavoni, V | 1 |
| Iacconi, P | 1 |
| Giunta, F | 1 |
| Forfori, F | 1 |
| Frank, LL | 1 |
| Gardiner, S | 1 |
| Hartzell, T | 1 |
| Dabar, G | 1 |
| Harmouche, C | 1 |
| Habr, B | 1 |
| Riachi, M | 1 |
| Jaber, B | 1 |
| van Snippenburg, W | 1 |
| Reijnders, MGJ | 1 |
| Hofhuis, JGM | 1 |
| de Vos, R | 1 |
| Kamphuis, S | 1 |
| Bedreag, OH | 1 |
| Rogobete, AF | 1 |
| Sandesc, D | 1 |
| Cradigati, CA | 1 |
| Sarandan, M | 1 |
| Popovici, SE | 1 |
| Dumache, R | 1 |
| Horhat, FG | 1 |
| Vernic, C | 1 |
| Sima, LV | 1 |
| Luca, L | 1 |
| Papurica, M | 1 |
| Corcoran, TB | 1 |
| O'Neill, MP | 1 |
| Webb, SA | 1 |
| Ho, KM | 1 |
| Carney, E | 1 |
| Cocchi, MN | 1 |
| Barbash, I | 1 |
| Chase, M | 1 |
| Joyce, N | 1 |
| Chou, PP | 1 |
| Ngo, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Thiamine Supplementation on Mortality in Septic Shock. A Controlled Before-and-after Study.[NCT05840718] | 80 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| A Multi-center, Randomized, Placebo-controlled, Double-blind, Adaptive Clinical Trial of Vitamin C, Thiamine and Steroids as Combination Therapy in Patients With Sepsis.[NCT03509350] | Phase 3 | 501 participants (Actual) | Interventional | 2018-08-22 | Completed | ||
| The Thiamine Administration After Cardiac Surgery Trial[NCT04641104] | Phase 4 | 200 participants (Actual) | Interventional | 2020-11-20 | Completed | ||
| The Effect of Thiamine on VO2 Levels in Critically Ill Patients[NCT01462279] | 20 participants (Actual) | Interventional | 2011-09-30 | Completed | |||
| Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock[NCT03380507] | Phase 2/Phase 3 | 106 participants (Actual) | Interventional | 2018-03-17 | Terminated (stopped due to The research is no longer funded and terminated due to futility) | ||
| Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans[NCT05480943] | 300 participants (Anticipated) | Observational | 2022-07-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Language is assessed with the Controlled Oral Word Association Test (COWAT). Participants generate words beginning with selected letters within 60 seconds. Generating a higher number of words indicates greater language skills. (NCT03509350)
Timeframe: Day 180
| Intervention | words (Mean) |
|---|---|
| Treatment Protocol | 40 |
| Control Protocol | 40 |
The Digit Span Test is used to assesses attention. In the Digit Span Test, participants are read a series of numbers and are asked to repeat them back in the same order. The Digit Span test is scored by the number of digits the participant is able to remember in each test. Higher scores indicate greater ability to pay attention and to remember sequences. The average adult can remember about 7 numbers, plus or minus two, without making an error. (NCT03509350)
Timeframe: Day 180
| Intervention | numbers recalled (Mean) |
|---|---|
| Treatment Protocol | 8.3 |
| Control Protocol | 9.5 |
Quality of life is assessed with the Visual Analog Scale of the EuroQol, 5 dimension (EQ-5D) questionnaire. The EQ-5D asks about 5 dimensions of health (mobility, self-care, usual activities, pain, and depression). The questionnaire includes a visual analog scale where respondents rate their current health where 0 = worst health imaginable and 100 = best health imaginable. (NCT03509350)
Timeframe: Day 180
| Intervention | units on a scale (Mean) |
|---|---|
| Treatment Protocol | 66 |
| Control Protocol | 67 |
Instrumental activities of daily living is assessed with the Functional Activities Questionnaire (FAQ). The FAQ includes 10 items which are scored on a scale from 0 to 3 where 0 = normal and 3 = dependent. Total scores range from 0 to 30 and lower scores indicate that the respondent is able to perform daily activities. A score of 9 (where the person is dependent in 3 activities) is used as a cut-point indicating impairments with functioning. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 9.5 |
| Control Protocol | 7.7 |
Executive function is assessed with the Hayling Test. The Hayling Test includes two parts of 15 items each where participants complete sentences by providing the missing word. The test is scored as the amount of time it takes, in seconds, to recite a correct response and the appropriateness of the response (in Part 2). Scaled scores range from 1 to 10 where 1 = impaired, 6 = average, and 10 = very superior. (NCT03509350)
Timeframe: Day 180
| Intervention | units on a scale (Mean) |
|---|---|
| Treatment Protocol | 4.2 |
| Control Protocol | 4.2 |
The number of participants who died while in the ICU is compared between study arms. (NCT03509350)
Timeframe: Day 30
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 52 |
| Control Protocol | 49 |
Activities of daily living is assessed with the Katz ADL instrument. The Katz ADL has 6 items asking if participants can perform daily tasks independently. Responses are scored as 1 = yes and 0 = no. Total scores range from 0 to 6 with higher scores indicating greater independence. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 2.8 |
| Control Protocol | 2.4 |
The number of days that participants were in the hospital is compared between study arms. (NCT03509350)
Timeframe: Day 30
| Intervention | days (Mean) |
|---|---|
| Treatment Protocol | 12.6 |
| Control Protocol | 13.5 |
The number of days that participants were in the ICU is compared between study arms. (NCT03509350)
Timeframe: Day 30
| Intervention | days (Mean) |
|---|---|
| Treatment Protocol | 6.7 |
| Control Protocol | 6.4 |
The number of participants who did not survive until Day 180 is compared between study arms. (NCT03509350)
Timeframe: Day 180
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 102 |
| Control Protocol | 94 |
The number of participants who did not survive until Day 30 is compared between study arms. (NCT03509350)
Timeframe: Day 30
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 56 |
| Control Protocol | 60 |
The Employment Questionnaire is a brief measure of the participant's employment history and ability or capacity to work. The number of participants who indicated being employed are presented here. (NCT03509350)
Timeframe: Day 180
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 17 |
| Control Protocol | 25 |
The Telephone CAM evaluates dementia with 9-items, where additional questions are asked if symptoms are present. Rather than providing a summary score, if participants exhibit signs of a change in mental status which fluctuates and they experience inattention, along with disorganized thinking or altered level of consciousness, delirium is suggested. (NCT03509350)
Timeframe: Day 180
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 0 |
| Control Protocol | 0 |
Depression is assessed with the PROMIS Depression 6 instrument. This tool includes 6 items with response options on a scale of 1 to 5. Total raw scores range from 6 to 30 with higher scores indicating greater symptoms of depression. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 11.9 |
| Control Protocol | 11.9 |
Posttraumatic Stress Disorder (PTSD) is assessed with the Posttraumatic Stress Disorder - 8 instrument. The PTSD-8 includes 8 items which are answered on a 4 point scale where 01 = not at all and 3 = all of the time. Total scores range from 0 to 24 where higher scores indicate greater symptoms of PTSD. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 5.7 |
| Control Protocol | 5.2 |
The Telephone Interview for Cognitive Status (TICS) is an 11-item instrument assessing orientation. Correct responses to the items are scored in a variety of ways, depending on how much of the response is correct. Total scores range from 0 to 41 with higher scores indicating increased cognitive orientation. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 30.6 |
| Control Protocol | 31.2 |
The primary outcome measure is VVFD in the first 30 days after the start of treatment. The endpoint was recorded to the nearest day. Participants who died are scored zero days, even if there was a period during which the participant was alive and free of vasopressors and mechanical ventilation. Participants who must return to ventilation and/or vasopressors had their counters reset at zero days. (NCT03509350)
Timeframe: Up to Day 30
| Intervention | days (Median) |
|---|---|
| Treatment Protocol | 25 |
| Control Protocol | 26 |
Reasoning is assessed with the WAIS-IV Similarities instrument. Participants were asked to explain how two words are alike. Responses are scored according to how correct they are, with a score of 0 for incorrect answers. After 3 consecutive scores of 0 the survey is stopped. Total raw scores vary depending on the number of word pairs presented. Higher scores indicate better performance. Scores will be compared between study arms. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 7.7 |
| Control Protocol | 8.2 |
Memory is assessed with the Logical Memory subtest from the Wechsler Memory Scale III. Participants listened to two short paragraphs and were asked to recall details from each story after 30 minutes. Scores represent the number of correctly remembered details. Total scores range from 0 to 25 with higher scores reflecting better memory. (NCT03509350)
Timeframe: Day 180
| Intervention | correct story details (Mean) |
|---|---|
| Treatment Protocol | 6.9 |
| Control Protocol | 8.1 |
VO2 measurements are taken at baseline and VO2 is continuously monitored over 9 hours. Thiamine is administered three hours after baseline measurements are taken. (NCT01462279)
Timeframe: Baseline to 9 Hours
| Intervention | ml/min (Mean) |
|---|---|
| Thiamine | 16.9 |
13 reviews available for thiamine and Critical Illness
| Article | Year |
|---|---|
Micronutrient intake from enteral nutrition in critically ill adults: A systematic review of randomised controlled trials.
Topics: Adult; Antioxidants; Ascorbic Acid; Critical Illness; Eating; Enteral Nutrition; Humans; Micronutrie | 2022 |
Update on vitamin C administration in critical illness.
Topics: Animals; Ascorbic Acid; Critical Illness; Humans; Hydrocortisone; Sepsis; Sheep; Thiamine; Vitamins | 2022 |
Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy.
Topics: Adult; Ascorbic Acid; Critical Illness; Humans; Micronutrients; Sepsis; Shock, Septic; Thiamine; Tra | 2023 |
Do micronutrient deficiencies contribute to mitochondrial failure in critical illness?
Topics: Animals; Antioxidants; Ascorbic Acid; Critical Care; Critical Care Outcomes; Critical Illness; Human | 2020 |
Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir.
Topics: Adrenal Cortex Hormones; Ascorbic Acid; Ascorbic Acid Deficiency; Clinical Protocols; Critical Illne | 2020 |
Effect of thiamine supplementation in critically ill patients: A systematic review and meta-analysis.
Topics: Critical Illness; Dietary Supplements; Humans; Intensive Care Units; Thiamine | 2021 |
Delirium in Critical Illness Patients and the Potential Role of Thiamine Therapy in Prevention and Treatment: Findings from a Scoping Review with Implications for Evidence-Based Practice.
Topics: Critical Illness; Delirium; Evidence-Based Practice; Humans; Intensive Care Units; Length of Stay; T | 2021 |
Vitamin B1 in critically ill patients: needs and challenges.
Topics: Acidosis; Chromatography, High Pressure Liquid; Critical Illness; Humans; Refeeding Syndrome; Refere | 2017 |
Thiamine content of F-75 therapeutic milk for complicated severe acute malnutrition: time for a change?
Topics: Animals; Critical Illness; Food, Fortified; Humans; Milk; Severe Acute Malnutrition; Thiamine; Thiam | 2017 |
Is refeeding syndrome relevant for critically ill patients?
Topics: Caloric Restriction; Critical Illness; Humans; Hypophosphatemia; Intensive Care Units; Magnesium; Ph | 2018 |
Vitamin therapy in critically ill patients: focus on thiamine, vitamin C, and vitamin D.
Topics: Ascorbic Acid; Critical Illness; Humans; Thiamine; Vitamin D; Vitamins | 2018 |
Vitamin C for the treatment of sepsis: The scientific rationale.
Topics: Adrenal Cortex Hormones; Animals; Antioxidants; Ascorbic Acid; Critical Illness; Humans; Sepsis; Thi | 2018 |
Wernicke encephalopathy: a medical emergency.
Topics: Critical Illness; Early Diagnosis; Emergencies; Female; Humans; Magnetic Resonance Imaging; Male; Pr | 2014 |
4 trials available for thiamine and Critical Illness
| Article | Year |
|---|---|
Relationship of blood thiamine pyrophosphate to plasma phosphate and the response to enteral nutrition plus co-administration of intravenous thiamine during critical illness.
Topics: Critical Illness; Enteral Nutrition; Humans; Phosphates; Thiamine; Thiamine Pyrophosphate | 2023 |
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
Topics: Adult; Aged; Anti-Inflammatory Agents; Ascorbic Acid; Critical Illness; Double-Blind Method; Drug Th | 2021 |
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
Topics: Adult; Aged; Anti-Inflammatory Agents; Ascorbic Acid; Critical Illness; Double-Blind Method; Drug Th | 2021 |
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
Topics: Adult; Aged; Anti-Inflammatory Agents; Ascorbic Acid; Critical Illness; Double-Blind Method; Drug Th | 2021 |
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.
Topics: Adult; Aged; Anti-Inflammatory Agents; Ascorbic Acid; Critical Illness; Double-Blind Method; Drug Th | 2021 |
A multicenter randomized clinical trial of pharmacological vitamin B1 administration to critically ill patients who develop hypophosphatemia during enteral nutrition (The THIAMINE 4 HYPOPHOSPHATEMIA trial).
Topics: Administration, Intravenous; Adult; Aged; Biomarkers; Critical Illness; Enteral Nutrition; Female; H | 2021 |
Intravenous thiamine is associated with increased oxygen consumption in critically ill patients with preserved cardiac index.
Topics: Adolescent; Adult; Aged; Critical Illness; Dose-Response Relationship, Drug; Female; Follow-Up Studi | 2014 |
23 other studies available for thiamine and Critical Illness
| Article | Year |
|---|---|
Thiamine Supplementation in Patients With Alcohol Use Disorder Presenting With Acute Critical Illness : A Nationwide Retrospective Observational Study.
Topics: Adult; Alcoholism; Critical Illness; Dietary Supplements; Humans; Male; Middle Aged; Retrospective S | 2022 |
Prevalence and Time Course of Thiamine Deficiency in Critically Ill Children: A Multicenter, Prospective Cohort Study in Turkey.
Topics: Child; Cohort Studies; Critical Illness; Humans; Intensive Care Units, Pediatric; Prevalence; Prospe | 2022 |
Evaluation of blood thiamine concentration in hospitalized dogs with and without critical illness.
Topics: Animals; Critical Illness; DNA-Binding Proteins; Dog Diseases; Dogs; Hospitalization; Hospitals, Ani | 2022 |
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study.
Topics: Ascorbic Acid; Critical Illness; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Shock, | 2023 |
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study.
Topics: Ascorbic Acid; Critical Illness; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Shock, | 2023 |
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study.
Topics: Ascorbic Acid; Critical Illness; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Shock, | 2023 |
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study.
Topics: Ascorbic Acid; Critical Illness; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Shock, | 2023 |
Thiamine Administration and the Prevalence of Delirium in the Intensive Care Unit: A Retrospective Before and After Interventional Study.
Topics: Critical Illness; Delirium; Humans; Intensive Care Units; Length of Stay; Prevalence; Prospective St | 2023 |
Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol.
Topics: Adult; Critical Care; Critical Illness; Delirium; Humans; Multicenter Studies as Topic; Respiration, | 2020 |
Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality.
Topics: Acute Kidney Injury; Adult; Aged; Animals; Critical Illness; Female; Gluconeogenesis; Glucose; Human | 2020 |
Evidence and Our Daily Risk Trade-offs in the Care of Critically Ill Patients.
Topics: Adult; Ascorbic Acid; Critical Illness; Humans; Hydrocortisone; Patients; Shock, Septic; Thiamine | 2020 |
Evaluation of thiamine as adjunctive therapy in COVID-19 critically ill patients: a two-center propensity score matched study.
Topics: Adult; COVID-19; COVID-19 Drug Treatment; Critical Illness; Female; Hospital Mortality; Humans; Inte | 2021 |
Micronutrient Alterations During Continuous Renal Replacement Therapy in Critically Ill Adults: A Retrospective Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ascorbic Acid; Body Mass Index; Copper; Critical Illness | 2018 |
Effect of blood thiamine concentrations on mortality: Influence of nutritional status.
Topics: Brazil; Child; Child Nutrition Disorders; Child, Preschool; Critical Illness; Female; Humans; Incide | 2018 |
Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock.
Topics: Adult; Aged; Cohort Studies; Critical Illness; Female; Follow-Up Studies; Humans; Intensive Care Uni | 2018 |
Thiamin Status in Adults Receiving Chronic Diuretic Therapy Prior to Admission to a Medical Intensive Care Unit: A Pilot Study.
Topics: Adult; Aged; Case-Control Studies; Critical Illness; Diuretics; Female; Furosemide; Hospitalization; | 2019 |
Vitamin C administration in the critically ill: a summary of recent meta-analyses.
Topics: Ascorbic Acid; Controlled Before-After Studies; Critical Illness; Humans; Hydrocortisone; Retrospect | 2019 |
Vitamin B deficiencies in a critically ill autistic child with a restricted diet.
Topics: Acidosis, Lactic; Autistic Disorder; Child; Critical Illness; Diet; Fast Foods; Feeding Behavior; He | 2015 |
Rapid reversal of severe lactic acidosis after thiamine administration in critically ill adults: a report of 3 cases.
Topics: Acidosis, Lactic; Administration, Intravenous; Adult; Aged; Critical Illness; Female; Humans; Nervou | 2015 |
Thiamin in Clinical Practice.
Topics: Adult; Child; Clinical Protocols; Critical Illness; Female; Humans; Male; Nutritional Support; Pregn | 2015 |
Thiamine deficiency: a cause of profound hypotension and hypothermia after plastic surgery.
Topics: Abdominoplasty; Administration, Intravenous; Aged; Critical Illness; Female; Humans; Hypotension; Hy | 2015 |
Shoshin Beriberi in Critically-Ill patients: case series.
Topics: Acidosis, Lactic; Beriberi; Critical Illness; Female; Humans; Infant; Infant, Newborn; Male; Parente | 2015 |
Thiamine Levels During Intensive Insulin Therapy in Critically Ill Patients.
Topics: Aged; Critical Care; Critical Illness; Female; Hospitalization; Humans; Hypoglycemic Agents; Insulin | 2017 |
Modulation of the Redox Expression and Inflammation Response in the Critically Ill Polytrauma Patient with Thoracic Injury. Statistical Correlations between Antioxidant Therapy.
Topics: Abbreviated Injury Scale; Acetylcysteine; Adult; Aged; Antioxidants; Ascorbic Acid; Critical Illness | 2016 |
Inflammation, vitamin deficiencies and organ failure in critically ill patients.
Topics: Adult; Aged; APACHE; Avitaminosis; Biomarkers; C-Reactive Protein; Cohort Studies; Critical Illness; | 2009 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |