Page last updated: 2024-10-20

thiamine and Cognition Disorders

thiamine has been researched along with Cognition Disorders in 35 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"The effects of chronic EtOH consumption, associated or not with thiamine deficiency (TD), on cognitive impairment, oxidative damage, and β-amyloid (Aβ) peptide accumulation in the brain were investigated in male C57BL/6 mice."7.85Comparative effects of EtOH consumption and thiamine deficiency on cognitive impairment, oxidative damage, and β-amyloid peptide overproduction in the brain. ( Gao, YQ; Gong, YS; Guo, J; Hou, FL; Hu, K; Liang, CY; Song, FL; Yang, LQ, 2017)
"This study explored the effect of thiamine deficiency during early infancy on the development of syntax and lexical retrieval."7.77The crucial role of thiamine in the development of syntax and lexical retrieval: a study of infantile thiamine deficiency. ( Fattal, I; Fattal-Valevski, A; Friedmann, N, 2011)
"Thiamine levels were selectively related to memory performance in the alcoholics."5.37Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndrome. ( Jackson, K; Pfefferbaum, A; Pitel, AL; Rosenbloom, MJ; Sassoon, SA; Sullivan, EV; Zahr, NM, 2011)
"The effects of chronic EtOH consumption, associated or not with thiamine deficiency (TD), on cognitive impairment, oxidative damage, and β-amyloid (Aβ) peptide accumulation in the brain were investigated in male C57BL/6 mice."3.85Comparative effects of EtOH consumption and thiamine deficiency on cognitive impairment, oxidative damage, and β-amyloid peptide overproduction in the brain. ( Gao, YQ; Gong, YS; Guo, J; Hou, FL; Hu, K; Liang, CY; Song, FL; Yang, LQ, 2017)
"Thiamine deficiency in patients who abuse alcohol can cause Wernicke's encephalopathy (WE)."3.79A novel scoring system to guide risk assessment of Wernicke's encephalopathy. ( Green, A; Parker, R; Williams, TM, 2013)
"This study explored the effect of thiamine deficiency during early infancy on the development of syntax and lexical retrieval."3.77The crucial role of thiamine in the development of syntax and lexical retrieval: a study of infantile thiamine deficiency. ( Fattal, I; Fattal-Valevski, A; Friedmann, N, 2011)
"Maternal thiamine deficiency causes changes in cellular energy metabolism that can interfere with offspring brain development."3.76Maternal thiamine restriction during lactation induces cognitive impairments and changes in glutamate and GABA concentrations in brain of rat offspring. ( de Freitas-Silva, DM; Franco, GC; Pereira, SR; Resende, Lde S; Ribeiro, AM, 2010)
" Here, we report that long-term administration of benfotiamine improved the cognitive ability of patients with AD."1.43Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease. ( Bao, W; Chen, Z; Fei, G; Guan, Y; Pan, S; Pan, X; Ren, S; Zhong, C, 2016)
"Thiamine levels were selectively related to memory performance in the alcoholics."1.37Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndrome. ( Jackson, K; Pfefferbaum, A; Pitel, AL; Rosenbloom, MJ; Sassoon, SA; Sullivan, EV; Zahr, NM, 2011)
" Here, we tested the effect of benfotiamine, a thiamine derivative with better bioavailability than thiamine, on cognitive impairment and pathology alterations in a mouse model of Alzheimer's disease, the amyloid precursor protein/presenilin-1 transgenic mouse."1.36Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. ( Chen, J; Dong, W; Fei, G; Gong, N; Gu, F; Pan, X; Qin, Y; Sun, X; Xu, TL; Xu, Z; Yu, M; Yu, Z; Zhao, J; Zhao, L; Zhong, C, 2010)
"The clinical features included confusion and/or clouding of consciousness, marked oppositional hypertonus ('gegenhalten') and myoclonus."1.27The clinical spectrum of alcoholic pellagra encephalopathy. A retrospective analysis of 22 cases studied pathologically. ( Buge, A; Castaigne, P; Goulon, M; Hausser-Hauw, C; Hauw, JJ; Laplane, D; Lhermitte, F; Serdaru, M, 1988)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.57)18.7374
1990's8 (22.86)18.2507
2000's6 (17.14)29.6817
2010's17 (48.57)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Orio, L1
Arias, F1
Escudero, B1
Gong, YS1
Hu, K1
Yang, LQ1
Guo, J1
Gao, YQ1
Song, FL1
Hou, FL1
Liang, CY1
Gautron, MA1
Questel, F1
Lejoyeux, M1
Bellivier, F1
Vorspan, F1
Chakraborty, PP1
Ghosh, S1
Dingwall, KM1
Delima, JF1
Gent, D1
Batey, RG1
Koh, F1
Charlton, K1
Walton, K1
McMahon, AT1
Pan, X2
Chen, Z1
Fei, G2
Pan, S1
Bao, W1
Ren, S1
Guan, Y1
Zhong, C2
Markova, N1
Bazhenova, N1
Anthony, DC1
Vignisse, J1
Svistunov, A1
Lesch, KP1
Bettendorff, L1
Strekalova, T1
de Freitas-Silva, DM1
Resende, Lde S1
Pereira, SR1
Franco, GC1
Ribeiro, AM2
Gong, N1
Zhao, J1
Yu, Z1
Gu, F1
Chen, J1
Sun, X1
Zhao, L1
Yu, M1
Xu, Z1
Dong, W1
Qin, Y1
Xu, TL1
Pitel, AL1
Zahr, NM1
Jackson, K1
Sassoon, SA1
Rosenbloom, MJ1
Pfefferbaum, A1
Sullivan, EV1
Fattal, I1
Friedmann, N1
Fattal-Valevski, A1
Sharma, TR1
Kavuru, B1
Iskandar, JW1
Coffman, A1
Johnson, K1
Endevelt, R1
Lemberger, J1
Bregman, J1
Kowen, G1
Berger-Fecht, I1
Lander, H1
Karpati, T1
Shahar, DR1
Srivastava, A1
Yadav, SK1
Borkar, VV1
Yadav, A1
Yachha, SK1
Thomas, MA1
Rathore, RK1
Pandey, CM1
Gupta, RK1
Dias, FM1
Silva, DM1
Doyle, FC1
Geisler, F1
Smyth, M1
Oechtering, J1
Tuetuencue, S1
Klostermann, F1
Nolte, CH1
Green, A1
Parker, R1
Williams, TM1
Heap, LC1
Pratt, OE1
Ward, RJ1
Waller, S1
Thomson, AD1
Shaw, GK1
Peters, TJ1
Buscaglia, J1
Faris, J1
Meador, KJ2
Nichols, ME1
Franke, P1
Durkin, MW1
Oberzan, RL1
Moore, EE1
Loring, DW1
Kanofsky, JD1
Bowden, S1
Bardenhagen, F1
Ambrose, M1
Whelan, G1
Eisinger, J1
Bates, CJ1
Zubaran, C1
Fernandes, J1
Martins, F1
Souza, J1
Machado, R1
Cadore, M1
Rodríguez-Martín, JL2
López-Arrieta, JM2
Qizilbash, N2
Bowden, SC1
Crews, FT1
Bates, ME1
Fals-Stewart, W1
Ambrose, ML1
Murata, T1
Fujito, T1
Kimura, H1
Omori, M1
Itoh, H1
Wada, Y1
Bell, IR1
Edman, JS1
Morrow, FD1
Marby, DW1
Perrone, G1
Kayne, HL1
Greenwald, M1
Cole, JO1
Vischer, A1
Hell, D1
Day, JJ1
Bayer, AJ1
McMahon, M1
Pathy, MS1
Spragg, BP1
Rowlands, DC1
Serdaru, M1
Hausser-Hauw, C1
Laplane, D1
Buge, A1
Castaigne, P1
Goulon, M1
Lhermitte, F1
Hauw, JJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Placebo-controlled, Crossover Study to Investigate the Safety and Efficacy of Qualia Mind on Cognition in a Healthy Population[NCT04389723]60 participants (Actual)Interventional2020-05-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for thiamine and Cognition Disorders

ArticleYear
Role of dietary protein and thiamine intakes on cognitive function in healthy older people: a systematic review.
    Nutrients, 2015, Apr-02, Volume: 7, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Cognition; Cognition Disorders; Databases, Factual; Dietary Proteins

2015
Treatment strategies for the cognitive deficits of Alzheimer's disease.
    Journal of the South Carolina Medical Association (1975), 1994, Volume: 90, Issue:11

    Topics: Alzheimer Disease; Amyloid; Antidepressive Agents; Cholinergic Agonists; Cognition Disorders; Humans

1994
Thiamine for Alzheimer's disease.
    The Cochrane database of systematic reviews, 2000, Issue:2

    Topics: Alzheimer Disease; Cognition Disorders; Humans; Thiamine

2000
Neurotoxicity and neurocognitive impairments with alcohol and drug-use disorders: potential roles in addiction and recovery.
    Alcoholism, clinical and experimental research, 2001, Volume: 25, Issue:2

    Topics: Alcoholism; Animals; Brain; Cognition Disorders; Humans; Nervous System Diseases; Substance-Related

2001
Thiamine for Alzheimer's disease.
    The Cochrane database of systematic reviews, 2001, Issue:2

    Topics: Alzheimer Disease; Cognition Disorders; Humans; Thiamine

2001

Trials

5 trials available for thiamine and Cognition Disorders

ArticleYear
Intensive dietary intervention by a dietitian as a case manager among community dwelling older adults: the EDIT study.
    The journal of nutrition, health & aging, 2011, Volume: 15, Issue:8

    Topics: Aged; Aged, 80 and over; Case Management; Cognition; Cognition Disorders; Depression; Dietary Carboh

2011
Evidence for a central cholinergic effect of high-dose thiamine.
    Annals of neurology, 1993, Volume: 34, Issue:5

    Topics: Adult; Cognition Disorders; Double-Blind Method; Electroencephalography; Female; Humans; Male; Memor

1993
Alcohol, thiamin deficiency, and neuropsychological disorders.
    Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1994, Volume: 2

    Topics: Adult; Alcohol Amnestic Disorder; Alcoholism; Brain Injuries; Cognition Disorders; Double-Blind Meth

1994
Brief communication. Vitamin B1, B2, and B6 augmentation of tricyclic antidepressant treatment in geriatric depression with cognitive dysfunction.
    Journal of the American College of Nutrition, 1992, Volume: 11, Issue:2

    Topics: Aged; Cognition Disorders; Depressive Disorder; Drug Therapy, Combination; Female; Folic Acid; Human

1992
Thiamine status, vitamin supplements and postoperative confusion.
    Age and ageing, 1988, Volume: 17, Issue:1

    Topics: Aged; Aged, 80 and over; Ascorbic Acid; Cognition Disorders; Confusion; Female; Femoral Fractures; H

1988

Other Studies

25 other studies available for thiamine and Cognition Disorders

ArticleYear
A case of Wernicke's encephalopathy that maintains long-term cognitive deterioration but not inflammation in spite of thiamine supplementation.
    Psychiatry and clinical neurosciences, 2022, Volume: 76, Issue:9

    Topics: Cognition; Cognition Disorders; Dietary Supplements; Humans; Thiamine; Thiamine Deficiency; Wernicke

2022
Comparative effects of EtOH consumption and thiamine deficiency on cognitive impairment, oxidative damage, and β-amyloid peptide overproduction in the brain.
    Free radical biology & medicine, 2017, Volume: 108

    Topics: Alcohol Drinking; Alcoholism; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Diet Thera

2017
Nutritional Status During Inpatient Alcohol Detoxification.
    Alcohol and alcoholism (Oxford, Oxfordshire), 2018, Jan-01, Volume: 53, Issue:1

    Topics: Adult; Aged; Alcoholism; Avitaminosis; Body Mass Index; Cognition Disorders; Female; Humans; Inpatie

2018
Wernicke's encephalopathy.
    The Journal of the Association of Physicians of India, 2013, Volume: 61, Issue:11

    Topics: Adult; Cognition Disorders; Humans; Magnetic Resonance Imaging; Male; Thiamine; Vitamin B Complex; W

2013
Hypomagnesaemia and its potential impact on thiamine utilisation in patients with alcohol misuse at the Alice Springs Hospital.
    Drug and alcohol review, 2015, Volume: 34, Issue:3

    Topics: Adult; Alcoholism; Cognition Disorders; Cross-Sectional Studies; Female; Humans; Male; Middle Aged;

2015
Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease.
    Neuroscience bulletin, 2016, Volume: 32, Issue:6

    Topics: Adjuvants, Immunologic; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Chromatograph

2016
Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2017, 04-03, Volume: 75

    Topics: Animals; Avoidance Learning; Brain; Cognition Disorders; Conditioning, Psychological; Disease Models

2017
Maternal thiamine restriction during lactation induces cognitive impairments and changes in glutamate and GABA concentrations in brain of rat offspring.
    Behavioural brain research, 2010, Jul-29, Volume: 211, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Suckling; Brain; Cognition Disorders; Energy Metabolism; Fem

2010
Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.
    Brain : a journal of neurology, 2010, Volume: 133, Issue:Pt 5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebral Cortex; Cognition; Cognition Diso

2010
Signs of preclinical Wernicke's encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff's syndrome.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011, Volume: 36, Issue:3

    Topics: Adult; Alcohol Amnestic Disorder; Alcoholism; Analysis of Variance; Cognition Disorders; Female; Fol

2011
The crucial role of thiamine in the development of syntax and lexical retrieval: a study of infantile thiamine deficiency.
    Brain : a journal of neurology, 2011, Volume: 134, Issue:Pt 6

    Topics: Association Learning; Chi-Square Distribution; Child; Child, Preschool; Cognition Disorders; Compreh

2011
A case of confabulation and abnormal eye movements.
    JAAPA : official journal of the American Academy of Physician Assistants, 2011, Volume: 24, Issue:9

    Topics: Adult; Cognition Disorders; Delirium; Eye Movements; Humans; Magnetic Resonance Imaging; Male; Neuro

2011
Serial evaluation of children with ALF with advanced MRI, serum proinflammatory cytokines, thiamine, and cognition assessment.
    Journal of pediatric gastroenterology and nutrition, 2012, Volume: 55, Issue:5

    Topics: Brain; Brain Edema; Case-Control Studies; Child; Child, Preschool; Choline; Cognition; Cognition Dis

2012
The connection between maternal thiamine shortcoming and offspring cognitive damage and poverty perpetuation in underprivileged communities across the world.
    Medical hypotheses, 2013, Volume: 80, Issue:1

    Topics: Central Nervous System; Cognition Disorders; Female; Humans; Poverty; Pregnancy; Prenatal Exposure D

2013
Auto-antibody-negative limbic-like encephalitis as the first manifestation of Neurosyphilis.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:8

    Topics: Aged; Alcoholism; Anticonvulsants; Autoantibodies; Cognition Disorders; Epilepsy, Generalized; Human

2013
A novel scoring system to guide risk assessment of Wernicke's encephalopathy.
    Alcoholism, clinical and experimental research, 2013, Volume: 37, Issue:5

    Topics: Cognition Disorders; Diet; Humans; Nausea; Retrospective Studies; Risk Assessment; Thiamine; Thiamin

2013
Individual susceptibility to Wernicke-Korsakoff syndrome and alcoholism-induced cognitive deficit: impaired thiamine utilization found in alcoholics and alcohol abusers.
    Psychiatric genetics, 2002, Volume: 12, Issue:4

    Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Brain Damage, Chronic; Cognition Disorders; Genetic Predi

2002
Unsteady, unfocused, and unable to hear.
    The American journal of medicine, 2005, Volume: 118, Issue:11

    Topics: Adolescent; Cognition Disorders; Combined Modality Therapy; Female; Fluid Therapy; Gait Disorders, N

2005
Thiamin status and cognitive impairment in the elderly.
    Journal of the American College of Nutrition, 1996, Volume: 15, Issue:3

    Topics: Aged; Alzheimer Disease; Cognition Disorders; Humans; Thiamine; Thiamine Deficiency

1996
Thiamin and cognitive impairment.
    Journal of the American College of Nutrition, 1997, Volume: 16, Issue:1

    Topics: Cognition Disorders; Humans; Thiamine

1997
Nutrition and cognitive function in the elderly.
    The American journal of clinical nutrition, 1997, Volume: 66, Issue:2

    Topics: Aged; Aged, 80 and over; Cognition; Cognition Disorders; Frail Elderly; Humans; Nutrition Policy; Nu

1997
[Clinical and neuropathological aspects of Wernicke-Korsakoff syndrome].
    Revista de saude publica, 1996, Volume: 30, Issue:6

    Topics: Alcohol Amnestic Disorder; Animals; Cognition Disorders; Humans; Prognosis; Rats; Syndrome; Thiamine

1996
Serial MRI and (1)H-MRS of Wernicke's encephalopathy: report of a case with remarkable cerebellar lesions on MRI.
    Psychiatry research, 2001, Nov-05, Volume: 108, Issue:1

    Topics: Aged; Cerebellum; Cognition Disorders; Humans; Magnetic Resonance Spectroscopy; Male; Neuropsycholog

2001
[Cognitive deficits, vitamin status and controlled thiamine substitution in alcohol dependent patients in withdrawal treatment].
    Der Nervenarzt, 1989, Volume: 60, Issue:10

    Topics: Adult; Alcoholism; Cognition Disorders; Ethanol; Follow-Up Studies; Humans; Male; Middle Aged; Neuro

1989
The clinical spectrum of alcoholic pellagra encephalopathy. A retrospective analysis of 22 cases studied pathologically.
    Brain : a journal of neurology, 1988, Volume: 111 ( Pt 4)

    Topics: Adult; Aged; Alcoholism; Cognition Disorders; Confusion; Consciousness Disorders; Female; Humans; Ma

1988