thiamine has been researched along with Blood Poisoning in 91 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To describe observed differences in long-term cognitive, psychological, and functional outcomes of vitamin C, thiamine, and hydrocortisone between the intervention and control groups in the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) randomized clinical trial." | 9.69 | Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial. ( Bastarache, J; Collar, EM; Ely, EW; Harrison, FE; Jackson, JC; Kiehl, AL; Lindsell, CJ; Mart, MF; Nwosu, S; Sevransky, JE; Williams Roberson, S; Wilson, JE, 2023) |
| " The mean malondialdehyde level was higher in patients of sepsis (1." | 9.51 | Effect of Supplementation of Vitamin C and Thiamine on the Outcome in Sepsis: South East Asian Region. ( Ap, GR; Daga, MK; Koner, BC; Kumar, N; Mawari, G; Mishra, R; Rohatgi, I; Singh, VK, 2022) |
| "This study explored the efficacy of hydrocortisone combined with vitamin C and thiamine (HVT) in the treatment of sepsis/septic shock." | 9.41 | Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis. ( Lu, D; Mao, W, 2023) |
| "To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis." | 9.41 | Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. ( Bernard, GR; Brown, SM; Buchman, TG; Busse, LW; Coopersmith, CM; DeWilde, C; Ely, EW; Eyzaguirre, LM; Fowler, AA; Gaieski, DF; Gong, MN; Hager, DN; Hall, A; Hinson, JS; Hooper, MH; Kelen, GD; Khan, A; Levine, MA; Lewis, RJ; Lindsell, CJ; Marlin, JS; Martin, GS; McGlothlin, A; Moore, BL; Nugent, KL; Nwosu, S; Polito, CC; Rice, TW; Ricketts, EP; Rothman, RE; Rudolph, CC; Sanfilippo, F; Sevransky, JE; Viele, K; Wright, DW, 2021) |
| "VICTAS is a large, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled trial that will test the efficacy of vitamin C, thiamine, and hydrocortisone as a combined therapy in patients with respiratory or circulatory dysfunction (or both) resulting from sepsis." | 9.30 | The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. ( Bernard, GR; Busse, LW; Ely, EW; Fowler, AA; Gaieski, DF; Hager, DN; Hall, A; Hinson, JS; Hooper, MH; Jackson, JC; Kelen, GD; Levine, M; Lindsell, CJ; Malone, RE; Martin, GS; McGlothlin, A; Rothman, RE; Sevransky, JE; Viele, K; Wright, DW, 2019) |
| "The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a multicenter, double-blind, adaptive sample size, randomized, placebo-controlled trial designed to test the efficacy of combination therapy with vitamin C (1." | 9.30 | Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. ( Bernard, GR; Busse, LW; Ely, EW; Fowler, AA; Gaieski, DF; Hager, DN; Hall, A; Hinson, JS; Hooper, MH; Jackson, JC; Kelen, GD; Levine, M; Lindsell, CJ; Martin, GS; McGlothlin, A; Nwosu, S; Rice, TW; Rothman, RE; Sevransky, JE; Viele, K; Wright, DW, 2019) |
| "There is a conflicting body of evidence regarding the benefit of vitamin C, thiamine, and hydrocortisone in combination as an adjunctive therapy for sepsis with or without septic shock." | 9.22 | Vitamin C, Thiamine, and Hydrocortisone in the Treatment of Sepsis: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. ( Alzghoul, BN; Banifadel, M; Borok, Z; Hyde, R; Jantz, M; Khasawneh, M; Reddy, R; Sutchu, S; Urbine, D; Venigandla, H; Zayed, Y, 2022) |
| "Among patients with sepsis and septic shock, a combination therapy of hydrocortisone, ascorbic acid, and thiamine, compared with placebo, could reduce the duration of vasopressor use and SOFA scores during the first 72 h." | 9.12 | Effect of Combined Hydrocortisone, Ascorbic Acid and Thiamine for Patients with Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. ( Hu, B; Hu, C; Huang, W; Li, J; Wu, T; Xu, Q, 2021) |
| "The trials compared a combination of thiamine, ascorbic acid, and hydrocortisone to standard care or placebo in patients admitted to ICU with sepsis or septic shock." | 9.12 | Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. ( Assouline, B; Bendjelid, K; Berchtold, L; de Seigneux, S; Elia, N; Faivre, A; Giraud, R; Legouis, D; Pugin, J; Sangla, F; Sgardello, S; Verissimo, T, 2021) |
| "To assess the effect from individual component in combinations of steroid, ascorbic acid, and thiamine on outcomes in adults with sepsis and septic shock with component network meta-analysis (NMA)." | 9.12 | Steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock: a systematic review and component network meta-analysis. ( Au, SY; Fong, KM; Ng, GWY, 2021) |
| "Despite widespread enthusiasm for thiamine combined with vitamin C for sepsis and septic shock, we only found an association with reduced SOFA score and time of vasopressor use." | 9.12 | Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis. ( Gao, Y; Ge, Z; Huang, J; Li, Y; Liu, Y; Lu, X; Walline, JH; Xiang, J; Yu, S; Zhao, L, 2021) |
| "Initial studies in patients with sepsis and septic shock demonstrated beneficial effects of ascorbic acid, thiamine, and steroids as monotherapy or in combination without safety concerns." | 9.05 | Vitamin C, Thiamine, and Steroids in the Sepsis Conquest: Replete to Defeat. ( Grace, Y; Guirguis, E; Maarsingh, H; Tkachuk, E; Tran, TC, 2020) |
| "The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock." | 8.98 | Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation. ( Andersen, LW; Becker, LB; Berg, KM; Cocchi, MN; Donnino, MW; Doshi, P; Gong, J; Grossestreuer, AV; Hou, PC; Huang, DT; Marik, PE; Moskowitz, A; Sen, A; Sherwin, RL, 2018) |
| "Evidence is emerging that parenteral administration of high-dose vitamin C and thiamine may be a beneficial adjuvant therapy of severe sepsis and septic shock." | 8.98 | Emerging Adjunctive Approach for the Treatment of Sepsis: Vitamin C and Thiamine. ( Badeaux, JE; Martin, JB, 2018) |
| "To determine circulating levels of ascorbic acid (VitC) and thiamine (VitB1) in neonates and children with blood culture-proven sepsis." | 8.12 | Serum Ascorbic Acid and Thiamine Concentrations in Sepsis: Secondary Analysis of the Swiss Pediatric Sepsis Study. ( Agyeman, PKA; Equey, L; Giannoni, E; Rezzi, S; Schlapbach, LJ; Veraguth, R, 2022) |
| "The efficacy of vitamin C (VitC) and thiamine (THMN) in patients admitted to the intensive care unit (ICU) with sepsis is unclear." | 7.96 | Vitamin C and thiamine are associated with lower mortality in sepsis. ( Byerly, S; Lee, EE; Mantero, A; Namias, N; Parks, JJ; Parreco, JP; Rattan, R; Shnaydman, I; Soe-Lin, H; Yeh, DD, 2020) |
| " Though further investigation is warranted, utilization of IV vitamin C, thiamine, and hydrocortisone in patients with sepsis or septic shock may be a treatment option worth considering." | 7.96 | Vitamin C and Thiamine for Sepsis and Septic Shock. ( Gillion, AR; Mitchell, AB; Muthiah, MP; Ryan, TE; Wells, LD, 2020) |
| "Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock." | 7.85 | Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. ( Catravas, J; Hooper, MH; Khangoora, V; Marik, PE; Rivera, R, 2017) |
| "The objective of the study was to determine the prevalence of absolute thiamine deficiency (TD) in critically ill patients with sepsis and to examine the association between thiamine levels and lactic acidosis." | 7.76 | Thiamine deficiency in critically ill patients with sepsis. ( Barbash, I; Carney, E; Chase, M; Chou, PP; Cocchi, MN; Donnino, MW; Joyce, N; Ngo, L, 2010) |
| "Sepsis is a life-threatening condition characterized by multiorgan dysfunction due to an exaggerated host response to infection associated with a homeostatic failure." | 7.01 | Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy. ( Hardy, G; Manzanares, W; Novoa, J, 2023) |
| "Sepsis and septic shock are severe medical conditions that can damage multiple organs with a higher risk of mortality." | 6.82 | Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review. ( Lee, YR; Varughese, JT; Vo, K, 2022) |
| " However, many questions remain regarding the optimal dosing regimens and plasma concentrations, timing of administration, and adverse effects of vitamin C and thiamine." | 6.66 | Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir. ( Halpern, NA; Obi, J; Pastores, SM; Ramanathan, LV; Yang, J, 2020) |
| "Sepsis is defined as the dysregulated host response to an infection resulting in life-threatening organ dysfunction." | 6.58 | A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. ( Belsky, JB; Jacob, V; Lee, PJ; Sather, JE; Wira, CR, 2018) |
| "Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost." | 6.58 | Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid. ( Marik, PE, 2018) |
| "Sepsis is a clinical syndrome characterised by a severe disorder of pathophysiology caused by infection of pathogenic micro-organisms." | 5.91 | Thiamine supplementation may be associated with improved prognosis in patients with sepsis. ( Huang, T; Li, S; Lyu, J; Xu, F; Yin, H; Zhang, F; Zhang, L; Zheng, X, 2023) |
| "Methods: Sepsis was induced using the cecal ligation and puncture (CLP) model of sepsis with fluid and antibiotic support." | 5.72 | HYDROCORTISONE, ASCORBIC ACID, AND THIAMINE THERAPY DECREASE RENAL OXIDATIVE STRESS AND ACUTE KIDNEY INJURY IN MURINE SEPSIS. ( Kim, J; Remick, D; Stolarski, A; Wee, K; Zhang, Q, 2022) |
| "To describe observed differences in long-term cognitive, psychological, and functional outcomes of vitamin C, thiamine, and hydrocortisone between the intervention and control groups in the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) randomized clinical trial." | 5.69 | Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial. ( Bastarache, J; Collar, EM; Ely, EW; Harrison, FE; Jackson, JC; Kiehl, AL; Lindsell, CJ; Mart, MF; Nwosu, S; Sevransky, JE; Williams Roberson, S; Wilson, JE, 2023) |
| "Sepsis is a common cause of death in intensive care unit." | 5.62 | [The controversy and value of the combination of hydrocortisone, ascorbic acid and thiamine in treating sepsis]. ( Song, WL; Wu, JF, 2021) |
| "Sepsis was induced in female mice using the cecal ligation and puncture (CLP) model." | 5.56 | Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) Therapy Decreases Oxidative Stress, Improves Cardiovascular Function, and Improves Survival in Murine Sepsis. ( Arnaout, L; Kim, J; Remick, D, 2020) |
| "Thiamine is an essential co-factor for aerobic metabolism." | 5.56 | Thiamine status and lactate concentration in sepsis: A prospective observational study. ( Annane, D; Bounab, R; Chevret, S; Heming, N; Meng, P; Salah, A; Sivanandamoorthy, S, 2020) |
| " The mean malondialdehyde level was higher in patients of sepsis (1." | 5.51 | Effect of Supplementation of Vitamin C and Thiamine on the Outcome in Sepsis: South East Asian Region. ( Ap, GR; Daga, MK; Koner, BC; Kumar, N; Mawari, G; Mishra, R; Rohatgi, I; Singh, VK, 2022) |
| "This study explored the efficacy of hydrocortisone combined with vitamin C and thiamine (HVT) in the treatment of sepsis/septic shock." | 5.41 | Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis. ( Lu, D; Mao, W, 2023) |
| "To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo in patients with sepsis." | 5.41 | Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. ( Bernard, GR; Brown, SM; Buchman, TG; Busse, LW; Coopersmith, CM; DeWilde, C; Ely, EW; Eyzaguirre, LM; Fowler, AA; Gaieski, DF; Gong, MN; Hager, DN; Hall, A; Hinson, JS; Hooper, MH; Kelen, GD; Khan, A; Levine, MA; Lewis, RJ; Lindsell, CJ; Marlin, JS; Martin, GS; McGlothlin, A; Moore, BL; Nugent, KL; Nwosu, S; Polito, CC; Rice, TW; Ricketts, EP; Rothman, RE; Rudolph, CC; Sanfilippo, F; Sevransky, JE; Viele, K; Wright, DW, 2021) |
| "The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) trial is a multicenter, double-blind, adaptive sample size, randomized, placebo-controlled trial designed to test the efficacy of combination therapy with vitamin C (1." | 5.30 | Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. ( Bernard, GR; Busse, LW; Ely, EW; Fowler, AA; Gaieski, DF; Hager, DN; Hall, A; Hinson, JS; Hooper, MH; Jackson, JC; Kelen, GD; Levine, M; Lindsell, CJ; Martin, GS; McGlothlin, A; Nwosu, S; Rice, TW; Rothman, RE; Sevransky, JE; Viele, K; Wright, DW, 2019) |
| "VICTAS is a large, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled trial that will test the efficacy of vitamin C, thiamine, and hydrocortisone as a combined therapy in patients with respiratory or circulatory dysfunction (or both) resulting from sepsis." | 5.30 | The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. ( Bernard, GR; Busse, LW; Ely, EW; Fowler, AA; Gaieski, DF; Hager, DN; Hall, A; Hinson, JS; Hooper, MH; Jackson, JC; Kelen, GD; Levine, M; Lindsell, CJ; Malone, RE; Martin, GS; McGlothlin, A; Rothman, RE; Sevransky, JE; Viele, K; Wright, DW, 2019) |
| "Sepsis trials examined 6 g/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone." | 5.22 | Update on vitamin C administration in critical illness. ( Bellomo, R; Fujii, T; Lankadeva, YR, 2022) |
| "There is a conflicting body of evidence regarding the benefit of vitamin C, thiamine, and hydrocortisone in combination as an adjunctive therapy for sepsis with or without septic shock." | 5.22 | Vitamin C, Thiamine, and Hydrocortisone in the Treatment of Sepsis: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. ( Alzghoul, BN; Banifadel, M; Borok, Z; Hyde, R; Jantz, M; Khasawneh, M; Reddy, R; Sutchu, S; Urbine, D; Venigandla, H; Zayed, Y, 2022) |
| "The trials compared a combination of thiamine, ascorbic acid, and hydrocortisone to standard care or placebo in patients admitted to ICU with sepsis or septic shock." | 5.12 | Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis. ( Assouline, B; Bendjelid, K; Berchtold, L; de Seigneux, S; Elia, N; Faivre, A; Giraud, R; Legouis, D; Pugin, J; Sangla, F; Sgardello, S; Verissimo, T, 2021) |
| "Among patients with sepsis and septic shock, a combination therapy of hydrocortisone, ascorbic acid, and thiamine, compared with placebo, could reduce the duration of vasopressor use and SOFA scores during the first 72 h." | 5.12 | Effect of Combined Hydrocortisone, Ascorbic Acid and Thiamine for Patients with Sepsis and Septic Shock: A Systematic Review and Meta-Analysis. ( Hu, B; Hu, C; Huang, W; Li, J; Wu, T; Xu, Q, 2021) |
| "Despite widespread enthusiasm for thiamine combined with vitamin C for sepsis and septic shock, we only found an association with reduced SOFA score and time of vasopressor use." | 5.12 | Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis. ( Gao, Y; Ge, Z; Huang, J; Li, Y; Liu, Y; Lu, X; Walline, JH; Xiang, J; Yu, S; Zhao, L, 2021) |
| "To assess the effect from individual component in combinations of steroid, ascorbic acid, and thiamine on outcomes in adults with sepsis and septic shock with component network meta-analysis (NMA)." | 5.12 | Steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock: a systematic review and component network meta-analysis. ( Au, SY; Fong, KM; Ng, GWY, 2021) |
| "Evidence from high-quality research is still insufficient to support the use of vitamin C, thiamine, and vitamin D as metabolic support in sepsis treatment." | 5.05 | Metabolic support in sepsis: corticosteroids and vitamins: the why, the when, the how. ( Deane, AM; Fujii, T; Nair, P, 2020) |
| " In clinical settings, high-dose selenium administration in sepsis has been disappointing." | 5.05 | Do micronutrient deficiencies contribute to mitochondrial failure in critical illness? ( Berger, MM, 2020) |
| "Initial studies in patients with sepsis and septic shock demonstrated beneficial effects of ascorbic acid, thiamine, and steroids as monotherapy or in combination without safety concerns." | 5.05 | Vitamin C, Thiamine, and Steroids in the Sepsis Conquest: Replete to Defeat. ( Grace, Y; Guirguis, E; Maarsingh, H; Tkachuk, E; Tran, TC, 2020) |
| "The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock." | 4.98 | Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation. ( Andersen, LW; Becker, LB; Berg, KM; Cocchi, MN; Donnino, MW; Doshi, P; Gong, J; Grossestreuer, AV; Hou, PC; Huang, DT; Marik, PE; Moskowitz, A; Sen, A; Sherwin, RL, 2018) |
| "Evidence is emerging that parenteral administration of high-dose vitamin C and thiamine may be a beneficial adjuvant therapy of severe sepsis and septic shock." | 4.98 | Emerging Adjunctive Approach for the Treatment of Sepsis: Vitamin C and Thiamine. ( Badeaux, JE; Martin, JB, 2018) |
| "Thiamine has a crucial role in energy production, and consequently thiamine deficiency (TD) has been associated with cardiac failure, neurological disorders, oxidative stress (lactic acidosis and sepsis) and refeeding syndrome (RFS)." | 4.95 | Vitamin B1 in critically ill patients: needs and challenges. ( Bellomo, R; Collie, JTB; Eastwood, GM; Greaves, RF; Jones, OAH; Lam, Q, 2017) |
| "Hydrocortisone, ascorbic acid, and thiamine therapy has minimal benefits in pneumonia." | 4.12 | Machine learning and murine models explain failures of clinical sepsis trials. ( Kim, J; Remick, DG; Rop, K; Stolarski, AE; Wee, K; Zhang, Q, 2022) |
| "To determine circulating levels of ascorbic acid (VitC) and thiamine (VitB1) in neonates and children with blood culture-proven sepsis." | 4.12 | Serum Ascorbic Acid and Thiamine Concentrations in Sepsis: Secondary Analysis of the Swiss Pediatric Sepsis Study. ( Agyeman, PKA; Equey, L; Giannoni, E; Rezzi, S; Schlapbach, LJ; Veraguth, R, 2022) |
| "Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis were limited by short-term vitamin C administration, heterogeneous populations, and the failure to evaluate each component's effect." | 4.12 | Vitamin C for ≥ 5 days is associated with decreased hospital mortality in sepsis subgroups: a nationwide cohort study. ( Baek, MS; Jung, SY; Kim, WY; Lee, MT, 2022) |
| "Triple therapy with steroids, vitamin C and thiamine has been recently proposed as a safe and beneficial in patients with sepsis." | 3.96 | Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study. ( Biagioni, E; Brugioni, L; Coloretti, I; Gelmini, R; Girardis, M; Munari, E; Roat, E; Tosi, M; Venturelli, C; Venturelli, S, 2020) |
| "The efficacy of vitamin C (VitC) and thiamine (THMN) in patients admitted to the intensive care unit (ICU) with sepsis is unclear." | 3.96 | Vitamin C and thiamine are associated with lower mortality in sepsis. ( Byerly, S; Lee, EE; Mantero, A; Namias, N; Parks, JJ; Parreco, JP; Rattan, R; Shnaydman, I; Soe-Lin, H; Yeh, DD, 2020) |
| " Though further investigation is warranted, utilization of IV vitamin C, thiamine, and hydrocortisone in patients with sepsis or septic shock may be a treatment option worth considering." | 3.96 | Vitamin C and Thiamine for Sepsis and Septic Shock. ( Gillion, AR; Mitchell, AB; Muthiah, MP; Ryan, TE; Wells, LD, 2020) |
| "Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine, are effective in preventing progressive organ dysfunction, including acute kidney injury, and in reducing the mortality of patients with severe sepsis and septic shock." | 3.85 | Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. ( Catravas, J; Hooper, MH; Khangoora, V; Marik, PE; Rivera, R, 2017) |
| "Thiamine deficiency has been associated with poorer clinical outcomes." | 3.77 | Low blood thiamine concentrations in children upon admission to the intensive care unit: risk factors and prognostic significance. ( Leite, HP; Lima, LF; Taddei, JA, 2011) |
| "The objective of the study was to determine the prevalence of absolute thiamine deficiency (TD) in critically ill patients with sepsis and to examine the association between thiamine levels and lactic acidosis." | 3.76 | Thiamine deficiency in critically ill patients with sepsis. ( Barbash, I; Carney, E; Chase, M; Chou, PP; Cocchi, MN; Donnino, MW; Joyce, N; Ngo, L, 2010) |
| "Sepsis is a life-threatening condition characterized by multiorgan dysfunction due to an exaggerated host response to infection associated with a homeostatic failure." | 3.01 | Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy. ( Hardy, G; Manzanares, W; Novoa, J, 2023) |
| "Sepsis and septic shock are severe medical conditions that can damage multiple organs with a higher risk of mortality." | 2.82 | Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review. ( Lee, YR; Varughese, JT; Vo, K, 2022) |
| "Sepsis is a condition characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection." | 2.82 | Beyond the bundle: Clinical controversies in the management of sepsis in emergency medicine patients. ( Bonderski, V; Krishnan, K; Rech, MA; Tednes, P; Wassermann, TB, 2022) |
| "Hydrocortisone combined with vitamin C and vitamin B1 can shorten the duration of vasoactive drugs in patients with sepsis or septic shock, but it cannot effectively reduce the SOFA score, mortality, new AKI patients, length of stay in ICU and in hospital." | 2.72 | [Therapeutic effect of hydrocortisone combined with vitamin C and vitamin B1 on patients with sepsis: a Meta-analysis]. ( Chang, C; Deng, G; Gao, Q; Luo, K; Zhu, H, 2021) |
| " However, many questions remain regarding the optimal dosing regimens and plasma concentrations, timing of administration, and adverse effects of vitamin C and thiamine." | 2.66 | Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir. ( Halpern, NA; Obi, J; Pastores, SM; Ramanathan, LV; Yang, J, 2020) |
| "Sepsis is associated with an acute deficiency of vitamin C." | 2.58 | Vitamin C for the treatment of sepsis: The scientific rationale. ( Marik, PE, 2018) |
| "Sepsis is defined as the dysregulated host response to an infection resulting in life-threatening organ dysfunction." | 2.58 | A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D. ( Belsky, JB; Jacob, V; Lee, PJ; Sather, JE; Wira, CR, 2018) |
| "Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost." | 2.58 | Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid. ( Marik, PE, 2018) |
| "Sepsis is a clinical syndrome characterised by a severe disorder of pathophysiology caused by infection of pathogenic micro-organisms." | 1.91 | Thiamine supplementation may be associated with improved prognosis in patients with sepsis. ( Huang, T; Li, S; Lyu, J; Xu, F; Yin, H; Zhang, F; Zhang, L; Zheng, X, 2023) |
| "Methods: Sepsis was induced using the cecal ligation and puncture (CLP) model of sepsis with fluid and antibiotic support." | 1.72 | HYDROCORTISONE, ASCORBIC ACID, AND THIAMINE THERAPY DECREASE RENAL OXIDATIVE STRESS AND ACUTE KIDNEY INJURY IN MURINE SEPSIS. ( Kim, J; Remick, D; Stolarski, A; Wee, K; Zhang, Q, 2022) |
| "Sepsis is common in foals and several treatments are used to facilitate recovery." | 1.62 | Blood thiamine (vitamin B ( Dembek, KA; Wong, DM; Young, L, 2021) |
| " These results demonstrate that RJX-P and RJX-B are bioequivalent relative to their pharmacodynamic effects on tissue SOD and ascorbic acid levels." | 1.62 | Non-clinical safety profile and pharmacodynamics of two formulations of the anti-sepsis drug candidate Rejuveinix (RJX). ( Orhan, C; Ozercan, IH; Powell, J; Sahin, E; Sahin, K; Uckun, FM; Volk, M, 2021) |
| "Sepsis is an extremely complex clinical syndrome, usually involving an excessive inflammatory response including an overshooting cytokine release that damages tissue and organs of the patient." | 1.62 | Ex Vivo Evaluation of the Sepsis Triple Therapy High-Dose Vitamin C in Combination with Vitamin B1 and Hydrocortisone in a Human Peripheral Blood Mononuclear Cells (PBMCs) Model. ( Burkard, M; Busch, C; Lauer, A; Leischner, C; Michels, H; Niessner, H; Renner, O; Sinnberg, T; Venturelli, S; Vollbracht, C, 2021) |
| "Sepsis is a common cause of death in intensive care unit." | 1.62 | [The controversy and value of the combination of hydrocortisone, ascorbic acid and thiamine in treating sepsis]. ( Song, WL; Wu, JF, 2021) |
| "Survivors and non-survivors of septic shock were similar." | 1.62 | Thiamine Status in Children with Septic Shock from a Developing Country: A Prospective Case-Control Study. ( Attri, SV; Baranwal, AK; Jayashree, M; Kumar-M, P; Patial, A; Raj, KM; Saini, AG, 2021) |
| "Sepsis was induced in female mice using the cecal ligation and puncture (CLP) model." | 1.56 | Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) Therapy Decreases Oxidative Stress, Improves Cardiovascular Function, and Improves Survival in Murine Sepsis. ( Arnaout, L; Kim, J; Remick, D, 2020) |
| "Thiamine is an essential co-factor for aerobic metabolism." | 1.56 | Thiamine status and lactate concentration in sepsis: A prospective observational study. ( Annane, D; Bounab, R; Chevret, S; Heming, N; Meng, P; Salah, A; Sivanandamoorthy, S, 2020) |
| "Sepsis was induced by cecal ligation and puncture with the cecum ligated below the cecal valve at 25%, 50%, and 75% of cecal length, defined as severe, moderate, and mild sepsis, respectively." | 1.43 | Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis. ( Fang, L; Said, HM; Sassoon, CS; Subramanian, VS; Zhu, E, 2016) |
| "This retrospective study included 132 polytrauma patients admitted to the ICU-CA between January 2013 and December 2014." | 1.43 | Modulation of the Redox Expression and Inflammation Response in the Critically Ill Polytrauma Patient with Thoracic Injury. Statistical Correlations between Antioxidant Therapy. ( Bedreag, OH; Cradigati, CA; Dumache, R; Horhat, FG; Luca, L; Papurica, M; Popovici, SE; Rogobete, AF; Sandesc, D; Sarandan, M; Sima, LV; Vernic, C, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.20) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 33 (36.26) | 24.3611 |
| 2020's | 56 (61.54) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, T | 1 |
| Hu, C | 1 |
| Huang, W | 1 |
| Xu, Q | 1 |
| Hu, B | 1 |
| Li, J | 1 |
| Assouline, B | 1 |
| Faivre, A | 1 |
| Verissimo, T | 1 |
| Sangla, F | 1 |
| Berchtold, L | 1 |
| Giraud, R | 1 |
| Bendjelid, K | 1 |
| Sgardello, S | 1 |
| Elia, N | 1 |
| Pugin, J | 1 |
| de Seigneux, S | 1 |
| Legouis, D | 1 |
| Fujii, T | 5 |
| Salanti, G | 1 |
| Belletti, A | 1 |
| Bellomo, R | 3 |
| Carr, A | 1 |
| Furukawa, TA | 1 |
| Luethi, N | 1 |
| Luo, Y | 1 |
| Putzu, A | 1 |
| Sartini, C | 1 |
| Tsujimoto, Y | 1 |
| Udy, AA | 2 |
| Yanase, F | 1 |
| Young, PJ | 1 |
| Krishnan, K | 1 |
| Wassermann, TB | 1 |
| Tednes, P | 1 |
| Bonderski, V | 1 |
| Rech, MA | 1 |
| Chang, C | 1 |
| Luo, K | 1 |
| Zhu, H | 1 |
| Deng, G | 1 |
| Gao, Q | 1 |
| Song, WL | 1 |
| Wu, JF | 1 |
| Jung, SY | 1 |
| Lee, MT | 1 |
| Baek, MS | 1 |
| Kim, WY | 1 |
| Ap, GR | 1 |
| Daga, MK | 1 |
| Mawari, G | 1 |
| Koner, BC | 1 |
| Singh, VK | 1 |
| Kumar, N | 1 |
| Rohatgi, I | 1 |
| Mishra, R | 1 |
| Wang, K | 1 |
| Yin, L | 1 |
| Song, Y | 1 |
| Zhang, M | 1 |
| Lu, Y | 1 |
| Wang, S | 1 |
| Equey, L | 1 |
| Agyeman, PKA | 1 |
| Veraguth, R | 1 |
| Rezzi, S | 1 |
| Schlapbach, LJ | 1 |
| Giannoni, E | 1 |
| Ragoonanan, D | 1 |
| Tran, N | 1 |
| Modi, V | 1 |
| Morgan Nickelsen, P | 1 |
| Lankadeva, YR | 1 |
| Stolarski, AE | 1 |
| Kim, J | 5 |
| Rop, K | 1 |
| Wee, K | 4 |
| Zhang, Q | 4 |
| Remick, DG | 1 |
| Uckun, FM | 2 |
| Saeed, M | 1 |
| Awili, M | 1 |
| Ozercan, IH | 2 |
| Qazi, S | 1 |
| Lee, C | 1 |
| Shibli, A | 1 |
| Skolnick, AW | 1 |
| Prusmack, A | 1 |
| Varon, J | 1 |
| Barrera, CI | 1 |
| Orhan, C | 2 |
| Volk, M | 2 |
| Sahin, K | 2 |
| Zhang, L | 1 |
| Zhang, F | 1 |
| Li, S | 1 |
| Xu, F | 1 |
| Zheng, X | 1 |
| Huang, T | 1 |
| Lyu, J | 1 |
| Yin, H | 1 |
| Suárez-de-la-Rica, A | 3 |
| Croes, B | 3 |
| Ciudad, L | 3 |
| Vallejo, I | 3 |
| Mújica, J | 3 |
| Díaz-Almirón, M | 3 |
| Maseda, E | 3 |
| Stolarski, A | 3 |
| Remick, D | 4 |
| Blakeslee, PA | 1 |
| Hyrkäs, K | 1 |
| Williams Roberson, S | 1 |
| Nwosu, S | 4 |
| Collar, EM | 1 |
| Kiehl, AL | 1 |
| Harrison, FE | 1 |
| Bastarache, J | 1 |
| Wilson, JE | 1 |
| Mart, MF | 1 |
| Sevransky, JE | 6 |
| Ely, EW | 5 |
| Lindsell, CJ | 5 |
| Jackson, JC | 4 |
| Novoa, J | 1 |
| Hardy, G | 1 |
| Manzanares, W | 1 |
| Lu, D | 1 |
| Mao, W | 1 |
| Jia, W | 1 |
| Zhang, X | 1 |
| Li, P | 1 |
| Song, C | 1 |
| Mitchell, AB | 1 |
| Ryan, TE | 1 |
| Gillion, AR | 1 |
| Wells, LD | 1 |
| Muthiah, MP | 1 |
| Scott, HF | 1 |
| Ho, VP | 1 |
| Kaafarani, H | 1 |
| Rattan, R | 2 |
| Namias, N | 2 |
| Evans, H | 1 |
| Zakrison, TL | 1 |
| McGlothlin, A | 4 |
| Rice, TW | 3 |
| Hall, A | 4 |
| Bernard, GR | 4 |
| Busse, LW | 4 |
| Fowler, AA | 4 |
| Gaieski, DF | 5 |
| Hinson, JS | 4 |
| Hooper, MH | 8 |
| Kelen, GD | 4 |
| Levine, M | 3 |
| Martin, GS | 5 |
| Rothman, RE | 4 |
| Viele, K | 4 |
| Wright, DW | 4 |
| Hager, DN | 5 |
| Spoelstra-de Man, AME | 3 |
| Oudemans-van Straaten, HM | 3 |
| Berger, MM | 2 |
| Kalil, AC | 2 |
| Byerly, S | 1 |
| Parreco, JP | 1 |
| Soe-Lin, H | 1 |
| Parks, JJ | 1 |
| Lee, EE | 1 |
| Shnaydman, I | 1 |
| Mantero, A | 1 |
| Yeh, DD | 1 |
| Heming, N | 1 |
| Salah, A | 1 |
| Meng, P | 1 |
| Sivanandamoorthy, S | 1 |
| Bounab, R | 1 |
| Chevret, S | 1 |
| Annane, D | 1 |
| Obi, J | 1 |
| Pastores, SM | 1 |
| Ramanathan, LV | 1 |
| Yang, J | 1 |
| Halpern, NA | 1 |
| Iglesias, J | 1 |
| Vassallo, AV | 1 |
| Patel, VV | 1 |
| Sullivan, JB | 1 |
| Cavanaugh, J | 1 |
| Elbaga, Y | 1 |
| Carr, AC | 2 |
| Frommelt, MA | 1 |
| Kory, P | 1 |
| Long, MT | 1 |
| Deane, AM | 1 |
| Nair, P | 1 |
| Coloretti, I | 1 |
| Biagioni, E | 1 |
| Venturelli, S | 2 |
| Munari, E | 1 |
| Tosi, M | 1 |
| Roat, E | 1 |
| Brugioni, L | 1 |
| Gelmini, R | 1 |
| Venturelli, C | 1 |
| Girardis, M | 1 |
| Files, DC | 1 |
| Liu, KD | 1 |
| Matthay, M | 1 |
| Fowler, R | 1 |
| Vincent, JL | 1 |
| Riessen, R | 1 |
| Choi, EJ | 1 |
| Jeon, CH | 1 |
| Park, DH | 1 |
| Kwon, TH | 1 |
| Raj, KM | 1 |
| Baranwal, AK | 1 |
| Attri, SV | 1 |
| Jayashree, M | 1 |
| Kumar-M, P | 1 |
| Patial, A | 1 |
| Saini, AG | 1 |
| Zayed, Y | 1 |
| Alzghoul, BN | 1 |
| Banifadel, M | 1 |
| Venigandla, H | 1 |
| Hyde, R | 1 |
| Sutchu, S | 1 |
| Khasawneh, M | 1 |
| Borok, Z | 1 |
| Urbine, D | 1 |
| Jantz, M | 1 |
| Reddy, R | 1 |
| Bauchner, H | 1 |
| Fontanarosa, PB | 1 |
| Golub, RM | 1 |
| Walter, KL | 1 |
| Seymour, CW | 1 |
| Brown, SM | 1 |
| Buchman, TG | 1 |
| Coopersmith, CM | 1 |
| DeWilde, C | 1 |
| Eyzaguirre, LM | 1 |
| Gong, MN | 1 |
| Khan, A | 1 |
| Levine, MA | 1 |
| Lewis, RJ | 1 |
| Marlin, JS | 1 |
| Moore, BL | 1 |
| Nugent, KL | 1 |
| Polito, CC | 1 |
| Ricketts, EP | 1 |
| Rudolph, CC | 1 |
| Sanfilippo, F | 1 |
| Ge, Z | 1 |
| Huang, J | 1 |
| Liu, Y | 1 |
| Xiang, J | 1 |
| Gao, Y | 1 |
| Walline, JH | 1 |
| Lu, X | 1 |
| Yu, S | 1 |
| Zhao, L | 1 |
| Li, Y | 1 |
| Müller, S | 1 |
| Wiesmann, T | 1 |
| Wulf, H | 1 |
| Arndt, C | 1 |
| Lee, YR | 1 |
| Vo, K | 1 |
| Varughese, JT | 1 |
| Wong, DM | 1 |
| Young, L | 1 |
| Dembek, KA | 1 |
| Powell, J | 1 |
| Sahin, E | 1 |
| Prasad, N | 1 |
| Grossestreuer, AV | 2 |
| Meyer, NJ | 1 |
| Perman, SM | 1 |
| Mikkelsen, ME | 1 |
| Hollander, J | 1 |
| Fong, KM | 1 |
| Au, SY | 1 |
| Ng, GWY | 1 |
| Lauer, A | 1 |
| Burkard, M | 1 |
| Niessner, H | 1 |
| Leischner, C | 1 |
| Renner, O | 1 |
| Vollbracht, C | 1 |
| Michels, H | 1 |
| Busch, C | 1 |
| Sinnberg, T | 1 |
| Collie, JTB | 1 |
| Greaves, RF | 1 |
| Jones, OAH | 1 |
| Lam, Q | 1 |
| Eastwood, GM | 1 |
| Elbers, PWG | 2 |
| Møller, MH | 1 |
| Laake, JH | 1 |
| Myburgh, JA | 1 |
| Alhazzani, W | 1 |
| Perner, A | 1 |
| Marik, PE | 8 |
| Khangoora, V | 3 |
| Rivera, R | 3 |
| Catravas, J | 3 |
| Flannery, AH | 2 |
| Bastin, MLT | 1 |
| Magee, CA | 1 |
| Bensadoun, ES | 1 |
| Johnson, DW | 1 |
| Cawcutt, KA | 1 |
| Gritsenko, D | 1 |
| Papadopoulos, J | 1 |
| Altshuler, D | 1 |
| Lee, YI | 1 |
| Altshuler, J | 1 |
| Thomas, M | 1 |
| Michelow, IC | 1 |
| Alhinai, Z | 1 |
| Dennehy, PH | 1 |
| Walter, JM | 1 |
| Singer, BD | 1 |
| Belsky, JB | 1 |
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| Jacob, V | 1 |
| Sather, JE | 1 |
| Lee, PJ | 1 |
| Woolum, JA | 1 |
| Abner, EL | 1 |
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| Huang, DT | 1 |
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| Cocchi, MN | 2 |
| Doshi, P | 1 |
| Gong, J | 1 |
| Sen, A | 1 |
| Donnino, MW | 2 |
| Nunnally, ME | 1 |
| Patel, A | 1 |
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| Parikh, R | 1 |
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| Tran, TC | 1 |
| Tkachuk, E | 1 |
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| Zhu, E | 1 |
| Fang, L | 1 |
| Subramanian, VS | 1 |
| Said, HM | 1 |
| Bedreag, OH | 1 |
| Rogobete, AF | 1 |
| Sandesc, D | 1 |
| Cradigati, CA | 1 |
| Sarandan, M | 1 |
| Popovici, SE | 1 |
| Dumache, R | 1 |
| Horhat, FG | 1 |
| Vernic, C | 1 |
| Sima, LV | 1 |
| Luca, L | 1 |
| Papurica, M | 1 |
| SCHATTENSTEIN, DI | 1 |
| GOTZMAN, RM | 1 |
| ALEKSANDROV, AF | 1 |
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| PECHNIKOVA, VN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1, Double-blind, Placebo-controlled, Randomized, Two-Part, Ascending Dose-escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Rejuveinix (RJX) in Healthy Participants[NCT03680105] | Phase 1 | 76 participants (Actual) | Interventional | 2018-08-24 | Completed | ||
| Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock: a Randomized Clinical Study (VITAMIN TRIAL)[NCT05192213] | Phase 3 | 1,090 participants (Anticipated) | Interventional | 2021-08-01 | Recruiting | ||
| A Multi-center, Randomized, Placebo-controlled, Double-blind, Adaptive Clinical Trial of Vitamin C, Thiamine and Steroids as Combination Therapy in Patients With Sepsis.[NCT03509350] | Phase 3 | 501 participants (Actual) | Interventional | 2018-08-22 | Completed | ||
| Outcomes of Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in the Early Treatment of Sepsis.[NCT03422159] | Phase 2 | 140 participants (Actual) | Interventional | 2018-02-05 | Completed | ||
| Impact of Thiamine Supplementation on Mortality in Septic Shock. A Controlled Before-and-after Study.[NCT05840718] | 80 participants (Anticipated) | Observational | 2023-09-30 | Not yet recruiting | |||
| The Thiamine Administration After Cardiac Surgery Trial[NCT04641104] | Phase 4 | 200 participants (Actual) | Interventional | 2020-11-20 | Completed | ||
| Effect of Intravenous Vitamin C on Sequential Organ Failure Assessment (SOFA) Score Among Septic Patients: Randomized Controlled Trial[NCT04137276] | 33 participants (Actual) | Interventional | 2019-04-01 | Completed | |||
| Effects of Enriched Oxygen Mixtures and Exercise on Oxidative Stress and Stem Cells Proliferation in Athletes.[NCT04366427] | Phase 2 | 42 participants (Actual) | Interventional | 2020-09-15 | Completed | ||
| Effect of Combined Vitamin C, Stress-dose Steroids, and Thiamine on Cerebral Autoregulation and Functional Outcomes of Patients With Septic Shock[NCT03649633] | Phase 1/Phase 2 | 100 participants (Anticipated) | Interventional | 2018-09-06 | Recruiting | ||
| Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock[NCT03828929] | Phase 3 | 3 participants (Actual) | Interventional | 2019-10-15 | Terminated (stopped due to Recent similar studies have been completed and published showing no benefit to the intervention.) | ||
| Early High-dose Vitamin C in Post-cardiac Arrest Syndrome[NCT03509662] | Phase 2 | 270 participants (Anticipated) | Interventional | 2019-10-07 | Recruiting | ||
| Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock[NCT03380507] | Phase 2/Phase 3 | 106 participants (Actual) | Interventional | 2018-03-17 | Terminated (stopped due to The research is no longer funded and terminated due to futility) | ||
| Ascorbic Ccid, Hydrocortisone, and Thiamine in Sepsis and Septic Shock - A Randomized, Double-Blind, Placebo-Controlled Trial[NCT03389555] | Phase 2/Phase 3 | 205 participants (Actual) | Interventional | 2018-02-09 | Completed | ||
| Combination Therapy of Vitamin C and Thiamine for Septic Shock: Multi-center, Double-blinded, Randomized, Controlled Study[NCT03756220] | Phase 2 | 116 participants (Actual) | Interventional | 2018-12-01 | Completed | ||
| A Randomized, Double Blind, Placebo-Controlled Trial to Investigate the Effect of Vitamin C, Hydrocortisone and Thiamine on the Outcome of Patients With Septic Shock[NCT03592693] | Phase 2 | 400 participants (Anticipated) | Interventional | 2018-09-06 | Recruiting | ||
| Effects of Vitamin C Administration on Extravascular Lung Water in Patients With Severe Features of Preeclampsia: a Randomized, Placebo-controlled Trial[NCT03451266] | Phase 1 | 34 participants (Actual) | Interventional | 2018-04-07 | Completed | ||
| A Randomized, Double Blind, Placebo-Controlled Study to Investigate the Effects of Vitamin C, Hydrocortisone and Thiamine on the Outcome of Patients With Severe Sepsis and Septic Shock[NCT03335124] | Phase 4 | 5 participants (Actual) | Interventional | 2017-09-26 | Terminated (stopped due to Due to insufficient recruitment) | ||
| Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock: A Prospective Study[NCT03258684] | 80 participants (Actual) | Interventional | 2017-09-25 | Completed | |||
| Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans[NCT05480943] | 300 participants (Anticipated) | Observational | 2022-07-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants with abnormal and clinically significant findings based on ECG. (NCT03680105)
Timeframe: Up to Day 2 for Part 1 and Up to Day 8 for Part 2
| Intervention | Participants (Count of Participants) |
|---|---|
| Part 1; Placebo | 0 |
| Part 1; Cohort 1; RJX | 0 |
| Part 1; Cohort 2; RJX | 0 |
| Part 1; Cohort 3; RJX | 0 |
| Part 1; Cohort 4; RJX | 0 |
| Part 1; Cohort 5; RJX | 0 |
| Part 1; Cohort 6; RJX | 0 |
| Part 2; Placebo | 0 |
| Part 2; Cohort 1; RJX | 0 |
| Part 2; Cohort 2; RJX | 0 |
| Part 2; Cohort 3; RJX | 0 |
Number of participants with clinically significant values and actual changes from baseline of continuous neurological assessments. (NCT03680105)
Timeframe: Up to Day 5 for Part 1 and Up to Day 12 for Part 2
| Intervention | Participants (Count of Participants) |
|---|---|
| Part 1; Placebo | 0 |
| Part 1; Cohort 1; RJX | 0 |
| Part 1; Cohort 2; RJX | 0 |
| Part 1; Cohort 3; RJX | 0 |
| Part 1; Cohort 4; RJX | 0 |
| Part 1; Cohort 5; RJX | 0 |
| Part 1; Cohort 6; RJX | 0 |
| Part 2; Placebo | 0 |
| Part 2; Cohort 1; RJX | 0 |
| Part 2; Cohort 2; RJX | 1 |
| Part 2; Cohort 3; RJX | 0 |
Number of participants with indicated AEs receiving RJX as assessed by CTCAE v4 03 (NCT03680105)
Timeframe: Up to Day 5 for Part 1 and Up to Day 12 for Part 2
| Intervention | Participants (Count of Participants) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mild TEAE72191553 | Mild TEAE72191554 | Mild TEAE72191555 | Mild TEAE72191556 | Mild TEAE72191557 | Mild TEAE72191558 | Mild TEAE72191559 | Mild TEAE72191560 | Mild TEAE72191562 | Mild TEAE72191563 | Mild TEAE72191561 | Moderate TEAE72191553 | Moderate TEAE72191554 | Moderate TEAE72191555 | Moderate TEAE72191556 | Moderate TEAE72191557 | Moderate TEAE72191558 | Moderate TEAE72191559 | Moderate TEAE72191560 | Moderate TEAE72191561 | Moderate TEAE72191562 | Moderate TEAE72191563 | Severe TEAE72191553 | Severe TEAE72191554 | Severe TEAE72191555 | Severe TEAE72191556 | Severe TEAE72191557 | Severe TEAE72191558 | Severe TEAE72191559 | Severe TEAE72191560 | Severe TEAE72191561 | Severe TEAE72191562 | Severe TEAE72191563 | Related TEAE72191553 | Related TEAE72191554 | Related TEAE72191555 | Related TEAE72191556 | Related TEAE72191558 | Related TEAE72191559 | Related TEAE72191560 | Related TEAE72191561 | Related TEAE72191562 | Related TEAE72191563 | Related TEAE72191557 | |||||||||||||||||||||||||||||||||||||||||||||
| Without TEAE | With TEAE | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Placebo | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 1; RJX | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 2; RJX | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 3; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 4; RJX | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 5; RJX | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 6; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Placebo | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 1; RJX | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 2; RJX | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 3; RJX | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Placebo | 11 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 1; RJX | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 2; RJX | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 3; RJX | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 5; RJX | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 6; RJX | 9 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Placebo | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 1; RJX | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 3; RJX | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Placebo | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 1; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 4; RJX | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 5; RJX | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 1; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 2; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 3; RJX | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Placebo | 13 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 1; RJX | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 2; RJX | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 4; RJX | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 5; RJX | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 1; RJX | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 2; RJX | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 3; RJX | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 2; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 4; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 5; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Placebo | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 4; RJX | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 5; RJX | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Placebo | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 2; RJX | 1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 2; RJX | 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 3; RJX | 0 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 2; RJX | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 1; Cohort 4; RJX | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 2; RJX | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Part 2; Cohort 3; RJX | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Language is assessed with the Controlled Oral Word Association Test (COWAT). Participants generate words beginning with selected letters within 60 seconds. Generating a higher number of words indicates greater language skills. (NCT03509350)
Timeframe: Day 180
| Intervention | words (Mean) |
|---|---|
| Treatment Protocol | 40 |
| Control Protocol | 40 |
The Digit Span Test is used to assesses attention. In the Digit Span Test, participants are read a series of numbers and are asked to repeat them back in the same order. The Digit Span test is scored by the number of digits the participant is able to remember in each test. Higher scores indicate greater ability to pay attention and to remember sequences. The average adult can remember about 7 numbers, plus or minus two, without making an error. (NCT03509350)
Timeframe: Day 180
| Intervention | numbers recalled (Mean) |
|---|---|
| Treatment Protocol | 8.3 |
| Control Protocol | 9.5 |
Quality of life is assessed with the Visual Analog Scale of the EuroQol, 5 dimension (EQ-5D) questionnaire. The EQ-5D asks about 5 dimensions of health (mobility, self-care, usual activities, pain, and depression). The questionnaire includes a visual analog scale where respondents rate their current health where 0 = worst health imaginable and 100 = best health imaginable. (NCT03509350)
Timeframe: Day 180
| Intervention | units on a scale (Mean) |
|---|---|
| Treatment Protocol | 66 |
| Control Protocol | 67 |
Instrumental activities of daily living is assessed with the Functional Activities Questionnaire (FAQ). The FAQ includes 10 items which are scored on a scale from 0 to 3 where 0 = normal and 3 = dependent. Total scores range from 0 to 30 and lower scores indicate that the respondent is able to perform daily activities. A score of 9 (where the person is dependent in 3 activities) is used as a cut-point indicating impairments with functioning. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 9.5 |
| Control Protocol | 7.7 |
Executive function is assessed with the Hayling Test. The Hayling Test includes two parts of 15 items each where participants complete sentences by providing the missing word. The test is scored as the amount of time it takes, in seconds, to recite a correct response and the appropriateness of the response (in Part 2). Scaled scores range from 1 to 10 where 1 = impaired, 6 = average, and 10 = very superior. (NCT03509350)
Timeframe: Day 180
| Intervention | units on a scale (Mean) |
|---|---|
| Treatment Protocol | 4.2 |
| Control Protocol | 4.2 |
The number of participants who died while in the ICU is compared between study arms. (NCT03509350)
Timeframe: Day 30
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 52 |
| Control Protocol | 49 |
Activities of daily living is assessed with the Katz ADL instrument. The Katz ADL has 6 items asking if participants can perform daily tasks independently. Responses are scored as 1 = yes and 0 = no. Total scores range from 0 to 6 with higher scores indicating greater independence. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 2.8 |
| Control Protocol | 2.4 |
The number of days that participants were in the hospital is compared between study arms. (NCT03509350)
Timeframe: Day 30
| Intervention | days (Mean) |
|---|---|
| Treatment Protocol | 12.6 |
| Control Protocol | 13.5 |
The number of days that participants were in the ICU is compared between study arms. (NCT03509350)
Timeframe: Day 30
| Intervention | days (Mean) |
|---|---|
| Treatment Protocol | 6.7 |
| Control Protocol | 6.4 |
The number of participants who did not survive until Day 180 is compared between study arms. (NCT03509350)
Timeframe: Day 180
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 102 |
| Control Protocol | 94 |
The number of participants who did not survive until Day 30 is compared between study arms. (NCT03509350)
Timeframe: Day 30
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 56 |
| Control Protocol | 60 |
The Employment Questionnaire is a brief measure of the participant's employment history and ability or capacity to work. The number of participants who indicated being employed are presented here. (NCT03509350)
Timeframe: Day 180
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 17 |
| Control Protocol | 25 |
The Telephone CAM evaluates dementia with 9-items, where additional questions are asked if symptoms are present. Rather than providing a summary score, if participants exhibit signs of a change in mental status which fluctuates and they experience inattention, along with disorganized thinking or altered level of consciousness, delirium is suggested. (NCT03509350)
Timeframe: Day 180
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Protocol | 0 |
| Control Protocol | 0 |
Depression is assessed with the PROMIS Depression 6 instrument. This tool includes 6 items with response options on a scale of 1 to 5. Total raw scores range from 6 to 30 with higher scores indicating greater symptoms of depression. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 11.9 |
| Control Protocol | 11.9 |
Posttraumatic Stress Disorder (PTSD) is assessed with the Posttraumatic Stress Disorder - 8 instrument. The PTSD-8 includes 8 items which are answered on a 4 point scale where 01 = not at all and 3 = all of the time. Total scores range from 0 to 24 where higher scores indicate greater symptoms of PTSD. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 5.7 |
| Control Protocol | 5.2 |
The Telephone Interview for Cognitive Status (TICS) is an 11-item instrument assessing orientation. Correct responses to the items are scored in a variety of ways, depending on how much of the response is correct. Total scores range from 0 to 41 with higher scores indicating increased cognitive orientation. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 30.6 |
| Control Protocol | 31.2 |
The primary outcome measure is VVFD in the first 30 days after the start of treatment. The endpoint was recorded to the nearest day. Participants who died are scored zero days, even if there was a period during which the participant was alive and free of vasopressors and mechanical ventilation. Participants who must return to ventilation and/or vasopressors had their counters reset at zero days. (NCT03509350)
Timeframe: Up to Day 30
| Intervention | days (Median) |
|---|---|
| Treatment Protocol | 25 |
| Control Protocol | 26 |
Reasoning is assessed with the WAIS-IV Similarities instrument. Participants were asked to explain how two words are alike. Responses are scored according to how correct they are, with a score of 0 for incorrect answers. After 3 consecutive scores of 0 the survey is stopped. Total raw scores vary depending on the number of word pairs presented. Higher scores indicate better performance. Scores will be compared between study arms. (NCT03509350)
Timeframe: Day 180
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Protocol | 7.7 |
| Control Protocol | 8.2 |
Memory is assessed with the Logical Memory subtest from the Wechsler Memory Scale III. Participants listened to two short paragraphs and were asked to recall details from each story after 30 minutes. Scores represent the number of correctly remembered details. Total scores range from 0 to 25 with higher scores reflecting better memory. (NCT03509350)
Timeframe: Day 180
| Intervention | correct story details (Mean) |
|---|---|
| Treatment Protocol | 6.9 |
| Control Protocol | 8.1 |
Defined as the day 4 post-randomization SOFA score minus the initial SOFA score. The Sequential Organ Failure Assessment (SOFA) Score is a mortality prediction score that is based on the degree of dysfunction of six organ systems. The score is calculated on admission and every 24 hours until discharge using the worst parameters measured during the prior 24 hours SOFA score ranges from 0 (no organ dysfunction) to 24 (highest possible score / organ dysfunction). (NCT03422159)
Timeframe: 4 days post-randomization
| Intervention | score on a scale (Mean) |
|---|---|
| Treatment Arm | 2.9 |
| Placebo Arm | 1.93 |
Time from admitting to discharge of hospital stay. (NCT03422159)
Timeframe: From admission to the hospital until final discharge, up to 28 days.
| Intervention | Days (Mean) |
|---|---|
| Treatment Arm | 11.5 |
| Placebo Arm | 11 |
In-hospital mortality rate. (NCT03422159)
Timeframe: Survival until hospital discharge, up to 28 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Arm | 11 |
| Placebo Arm | 13 |
Time from admitting to ICU to discharge. (NCT03422159)
Timeframe: From admission to the ICU until final discharge from the ICU, up to an average of 7 days.
| Intervention | days (Mean) |
|---|---|
| Treatment Arm | 4.76 |
| Placebo Arm | 4.66 |
ICU mortality rate (NCT03422159)
Timeframe: From admission to hospital until final discharge from the ICU, up to 28 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Treatment Arm | 6 |
| Placebo Arm | 10 |
PCT at 96 hours minus initial PCT, divided by the initial PCT multiplied by 100. (NCT03422159)
Timeframe: 4 days post-randomization
| Intervention | Percent (Mean) |
|---|---|
| Treatment Arm | 63 |
| Placebo Arm | 58 |
Defined as the time from starting the active treatment/placebo to discontinuation of all pressors. (NCT03422159)
Timeframe: From start of vasopressor medication to final discontinuation of vasopressor medication, up to 7 days.
| Intervention | hours (Mean) |
|---|---|
| HAT Treatment | 27 |
| Comparator | 53 |
Number of days alive and off of the ventilator at day 28. (NCT03422159)
Timeframe: 28 Days post-randomization
| Intervention | Days (Mean) |
|---|---|
| Treatment Arm | 22 |
| Placebo Arm | 22.4 |
Mortality rate (NCT03389555)
Timeframe: Enrollment until 30-days after enrollment
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 35 |
| Placebo | 29 |
Home hospital disposition in patients who survive to discharge (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days, whichever comes first.
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 34 |
| Placebo | 35 |
Hospital mortality rate (NCT03389555)
Timeframe: Enrollment until hospital discharge, death, or 30-days. Whichever comes first.
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 28 |
| Placebo | 23 |
Number of days that the patient was not in the ICU. Timeframe listed below. (NCT03389555)
Timeframe: From enrollment until 28 days after enrollment
| Intervention | Days (Median) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 22 |
| Placebo | 21 |
ICU mortality rate (NCT03389555)
Timeframe: Enrollment until ICU discharge, death, or 30-days. Whichever comes first.
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 23 |
| Placebo | 20 |
"Describes if patient has delirium as defined by the Confusion Assessment Method (CAM)-ICU. The CAM-ICU method requires that the patient have 3 features to qualify for delirium:~Acute Onset of Changes or Fluctuations in the Course of Mental Status (AND )~Inattention (AND)~Disorganized thinking (OR) Altered Level of Consciousness" (NCT03389555)
Timeframe: On day 3 (at approximately 72 hours) after the first study drug dose
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 31 |
| Placebo | 35 |
"Development of renal failure as defined by a Kidney Disease Improving Global Outcomes [KDIGO] stage 3 or higher. There are 3 stages in the KDIGO scale with stage 3 being the worst (corresponds to renal failure).~Stage 1- serum creatinine 1.5 to 1.9 times baseline OR an increase in serum creatinine ≥ 0.3 mg/dL OR urine output < 0.5ml/kg/hour for 6-12 hours. Stage 2- serum creatinine 2.0-2.9 times baseline OR urine output <0.5mg/kg/hour for ≥ 12 hours Stage 3- serum creatinine 3.0 times baseline (or serum creatinine of more than or equal to 4.0 mg/dl with an acute increase of at least 0.5 mg/dl) (OR) Urine output less than 0.3 ml/kg/hour for 24 hours or anuria for 12 hours or new renal replacement therapy" (NCT03389555)
Timeframe: Enrollment until 7-days or discharge from the ICU
| Intervention | Participants (Count of Participants) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 32 |
| Placebo | 27 |
Days not receiving vasopressor (NCT03389555)
Timeframe: Vasopressor free days over the first 7-days after enrollment
| Intervention | Days (Median) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 5 |
| Placebo | 4 |
Days not receiving invasive mechanical ventilation (NCT03389555)
Timeframe: Ventilator free days over the first 7-days after enrollment
| Intervention | Days (Median) |
|---|---|
| Vitamin C, Vitamin B1, Corticosteroids | 6 |
| Placebo | 6 |
Sequential Organ Failure Assessment (SOFA) Score at Baseline and 72 Hours. The SOFA score ranges from a minimum of 0 to a maximum of 24, with higher scores meaning worse outcomes. (NCT03389555)
Timeframe: Enrollment to 72-hours
| Intervention | Units on a scale (Mean) | |
|---|---|---|
| Enrollment SOFA score | 72 hour SOFA score | |
| Placebo | 9.2 | 5.1 |
| Vitamin C, Vitamin B1, Corticosteroids | 9.1 | 4.4 |
27 reviews available for thiamine and Blood Poisoning
| Article | Year |
|---|---|
Effect of Combined Hydrocortisone, Ascorbic Acid and Thiamine for Patients with Sepsis and Septic Shock: A Systematic Review and Meta-Analysis.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Sepsis; Shock, Septic; Thiamine | 2021 |
Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis.
Topics: Ascorbic Acid; Drug Combinations; Humans; Hydrocortisone; Metabolism; Ontario; Randomized Controlled | 2021 |
Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis.
Topics: Adult; Ascorbic Acid; Glucocorticoids; Humans; Network Meta-Analysis; Sepsis; Shock, Septic; Thiamin | 2022 |
Beyond the bundle: Clinical controversies in the management of sepsis in emergency medicine patients.
Topics: Angiotensin II; Ascorbic Acid; Crystalloid Solutions; Disease Management; Drug Therapy, Combination; | 2022 |
[Therapeutic effect of hydrocortisone combined with vitamin C and vitamin B1 on patients with sepsis: a Meta-analysis].
Topics: Ascorbic Acid; Humans; Hydrocortisone; Intensive Care Units; Sepsis; Thiamine | 2021 |
The Use of Hydrocortisone, Ascorbic Acid and Thiamine in Patients with Sepsis and Septic Shock - A Systematic Review.
Topics: Ascorbic Acid; Drug Therapy, Combination; Humans; Hydrocortisone; Sepsis; Shock, Septic; Thiamine | 2023 |
Unanswered questions on the use of hydrocortisone, ascorbic acid, and thiamine therapy in sepsis and septic shock.
Topics: Ascorbic Acid; Drug Therapy, Combination; Humans; Hydrocortisone; Retrospective Studies; Sepsis; Sho | 2022 |
Update on vitamin C administration in critical illness.
Topics: Animals; Ascorbic Acid; Critical Illness; Humans; Hydrocortisone; Sepsis; Sheep; Thiamine; Vitamins | 2022 |
Impact of supplemental thiamin on lactate levels in adults with septic shock.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Lactic Acid; Observational Studies as Topic; Retrospective St | 2023 |
Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy.
Topics: Adult; Ascorbic Acid; Critical Illness; Humans; Micronutrients; Sepsis; Shock, Septic; Thiamine; Tra | 2023 |
Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Intensive Care Units; Sepsis; Shock, Septic; Thiamine | 2023 |
Sepsis 2019: What Surgeons Need to Know.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Angiotensin II; Anti-Bacterial Agents; Antioxidan | 2020 |
Do micronutrient deficiencies contribute to mitochondrial failure in critical illness?
Topics: Animals; Antioxidants; Ascorbic Acid; Critical Care; Critical Care Outcomes; Critical Illness; Human | 2020 |
Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir.
Topics: Adrenal Cortex Hormones; Ascorbic Acid; Ascorbic Acid Deficiency; Clinical Protocols; Critical Illne | 2020 |
Metabolic support in sepsis: corticosteroids and vitamins: the why, the when, the how.
Topics: Adrenal Cortex Hormones; Ascorbic Acid; Humans; Sepsis; Thiamine; Vitamins | 2020 |
Vitamin C, Thiamine, and Hydrocortisone in the Treatment of Sepsis: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials.
Topics: Aged; Aged, 80 and over; Ascorbic Acid; Female; Humans; Hydrocortisone; Male; Middle Aged; Randomize | 2022 |
Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis.
Topics: Ascorbic Acid; Humans; Sepsis; Shock, Septic; Thiamine; Vitamins | 2021 |
Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in sepsis and septic shock: A systematic review.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Sepsis; Shock, Septic; Thiamine | 2022 |
Steroid, ascorbic acid, and thiamine in adults with sepsis and septic shock: a systematic review and component network meta-analysis.
Topics: Ascorbic Acid; Drug Therapy, Combination; Female; Fludrocortisone; Glucocorticoids; Humans; Male; Ra | 2021 |
Vitamin B1 in critically ill patients: needs and challenges.
Topics: Acidosis; Chromatography, High Pressure Liquid; Critical Illness; Humans; Refeeding Syndrome; Refere | 2017 |
Vitamin C for the treatment of sepsis: The scientific rationale.
Topics: Adrenal Cortex Hormones; Animals; Antioxidants; Ascorbic Acid; Critical Illness; Humans; Sepsis; Thi | 2018 |
A review of micronutrients in sepsis: the role of thiamine, l-carnitine, vitamin C, selenium and vitamin D.
Topics: Ascorbic Acid; Carnitine; Deficiency Diseases; Dietary Supplements; Humans; Micronutrients; Nutritio | 2018 |
Emerging Adjunctive Approach for the Treatment of Sepsis: Vitamin C and Thiamine.
Topics: Antioxidants; Ascorbic Acid; Critical Care; Hospital Mortality; Humans; Intensive Care Units; Sepsis | 2018 |
Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Ascorbic Acid; Drug Therapy, Combination; Humans; Hy | 2018 |
Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid.
Topics: Ascorbic Acid; Drug Therapy, Combination; Humans; Hydrocortisone; Sepsis; Thiamine | 2018 |
Sepsis - What's new in 2019?
Topics: Angiotensin II; Anti-Bacterial Agents; Ascorbic Acid; Biomarkers; Combined Modality Therapy; Critica | 2019 |
Vitamin C, Thiamine, and Steroids in the Sepsis Conquest: Replete to Defeat.
Topics: Ascorbic Acid; Humans; Sepsis; Shock, Septic; Thiamine; Vitamins | 2020 |
6 trials available for thiamine and Blood Poisoning
58 other studies available for thiamine and Blood Poisoning
| Article | Year |
|---|---|
[The controversy and value of the combination of hydrocortisone, ascorbic acid and thiamine in treating sepsis].
Topics: Ascorbic Acid; Humans; Hydrocortisone; Retrospective Studies; Sepsis; Thiamine | 2021 |
Vitamin C for ≥ 5 days is associated with decreased hospital mortality in sepsis subgroups: a nationwide cohort study.
Topics: Adolescent; Adult; Aged; Ascorbic Acid; Cohort Studies; Drug Therapy, Combination; Hospital Mortalit | 2022 |
Serum Ascorbic Acid and Thiamine Concentrations in Sepsis: Secondary Analysis of the Swiss Pediatric Sepsis Study.
Topics: Adolescent; Ascorbic Acid; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Sepsis; Switzer | 2022 |
Machine learning and murine models explain failures of clinical sepsis trials.
Topics: Animals; Ascorbic Acid; Biomarkers; Cecum; Cytokines; Disease Models, Animal; Hydrocortisone; Ligati | 2022 |
Evaluation of the potential of Rejuveinix plus dexamethasone against sepsis.
Topics: Animals; Anti-Inflammatory Agents; Ascorbic Acid; COVID-19 Drug Treatment; Dexamethasone; Disease Mo | 2022 |
Thiamine supplementation may be associated with improved prognosis in patients with sepsis.
Topics: Dietary Supplements; Humans; Prognosis; Retrospective Studies; Sepsis; Thiamine | 2023 |
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study.
Topics: Ascorbic Acid; Critical Illness; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Shock, | 2023 |
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study.
Topics: Ascorbic Acid; Critical Illness; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Shock, | 2023 |
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study.
Topics: Ascorbic Acid; Critical Illness; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Shock, | 2023 |
Vitamin C and thiamine for the treatment of refractory septic shock in surgical critically ill patients: a retrospective before-and-after study.
Topics: Ascorbic Acid; Critical Illness; Humans; Intensive Care Units; Retrospective Studies; Sepsis; Shock, | 2023 |
HYDROCORTISONE, ASCORBIC ACID, AND THIAMINE THERAPY DECREASE RENAL OXIDATIVE STRESS AND ACUTE KIDNEY INJURY IN MURINE SEPSIS.
Topics: Acute Kidney Injury; Animals; Ascorbic Acid; Hydrocortisone; Kidney; Mice; Oxidative Stress; Sepsis; | 2022 |
HYDROCORTISONE, ASCORBIC ACID, AND THIAMINE THERAPY DECREASE RENAL OXIDATIVE STRESS AND ACUTE KIDNEY INJURY IN MURINE SEPSIS.
Topics: Acute Kidney Injury; Animals; Ascorbic Acid; Hydrocortisone; Kidney; Mice; Oxidative Stress; Sepsis; | 2022 |
HYDROCORTISONE, ASCORBIC ACID, AND THIAMINE THERAPY DECREASE RENAL OXIDATIVE STRESS AND ACUTE KIDNEY INJURY IN MURINE SEPSIS.
Topics: Acute Kidney Injury; Animals; Ascorbic Acid; Hydrocortisone; Kidney; Mice; Oxidative Stress; Sepsis; | 2022 |
HYDROCORTISONE, ASCORBIC ACID, AND THIAMINE THERAPY DECREASE RENAL OXIDATIVE STRESS AND ACUTE KIDNEY INJURY IN MURINE SEPSIS.
Topics: Acute Kidney Injury; Animals; Ascorbic Acid; Hydrocortisone; Kidney; Mice; Oxidative Stress; Sepsis; | 2022 |
Changes and Clinical Significance of Vitamin B1 in Children with Sepsis.
Topics: Child; Clinical Relevance; Humans; Sepsis; Thiamine; Vitamin D | 2023 |
Vitamin C and Thiamine for Sepsis and Septic Shock.
Topics: Aged; Ascorbic Acid; Clinical Protocols; Critical Care; Female; Humans; Hydrocortisone; Infusions, I | 2020 |
Thiamine in Pediatric Sepsis: A Motivating Study.
Topics: Child; Humans; Hyperlactatemia; Retrospective Studies; Sepsis; Shock, Septic; Thiamine; Thiamine Def | 2019 |
Adjuvant vitamin C for sepsis: mono or triple?
Topics: Antioxidants; Ascorbic Acid; Humans; Reactive Oxygen Species; Sepsis; Survival Analysis; Thiamine | 2019 |
Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Sepsis; Shock, Septic; Thiamine; Vitamins | 2020 |
Vitamin C and thiamine are associated with lower mortality in sepsis.
Topics: Aged; APACHE; Ascorbic Acid; Female; Hospital Mortality; Humans; Intensive Care Units; Lactates; Mal | 2020 |
Thiamine status and lactate concentration in sepsis: A prospective observational study.
Topics: Adult; Aged; Female; Humans; Intensive Care Units; Lactic Acid; Male; Middle Aged; Prospective Studi | 2020 |
Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C?
Topics: Adrenal Cortex Hormones; Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Ret | 2020 |
In response: Letter on update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol.
Topics: Anti-Inflammatory Agents; Ascorbic Acid; Drug Therapy, Combination; Humans; Hydrocortisone; Sepsis; | 2020 |
Letter on Update to the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Protocol.
Topics: Ascorbic Acid; Humans; Intensive Care Units; Randomized Controlled Trials as Topic; Sepsis; Steroids | 2020 |
Adjunctive therapy with vitamin c and thiamine in patients treated with steroids for refractory septic shock: A propensity matched before-after, case-control study.
Topics: Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Ascorbic Acid; Case-Control Stud | 2020 |
Additional Trials of Vitamin C in Septic Shock: A Bag of Mixed Fruit.
Topics: Ascorbic Acid; Citrus sinensis; Fruit; Glucocorticoids; Humans; Sepsis; Shock, Septic; Thiamine | 2020 |
Need for Additional Trials of Vitamin C for Sepsis.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Sepsis; Thiamine; Vitamins | 2020 |
Vitamin C and thiamine for sepsis: time to go back to fundamental principles.
Topics: Ascorbic Acid; Humans; Sepsis; Shock, Septic; Thiamine; Vitamins | 2020 |
[Ascorbic acid, corticosteroids, and thiamine-effect on organ injury in septic shock].
Topics: Adrenal Cortex Hormones; Ascorbic Acid; Humans; Hydrocortisone; Sepsis; Shock, Septic; Thiamine | 2021 |
Allithiamine Exerts Therapeutic Effects on Sepsis by Modulating Metabolic Flux during Dendritic Cell Activation.
Topics: Animals; Dendritic Cells; Humans; Male; Mice; Sepsis; Thiamine | 2020 |
Thiamine Status in Children with Septic Shock from a Developing Country: A Prospective Case-Control Study.
Topics: Aftercare; Case-Control Studies; Child; Developing Countries; Humans; Patient Discharge; Prospective | 2021 |
Funding and DSMB Membership in the VICTAS Clinical Trial.
Topics: Ascorbic Acid; Clinical Trials Data Monitoring Committees; Humans; Hydrocortisone; Sepsis; Thiamine; | 2021 |
Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Sepsis; Thiamine; Ventilators, Mechanical | 2021 |
[Vitamin C - New Option in Sepsis Therapy?]
Topics: Ascorbic Acid; Humans; Hydrocortisone; Sepsis; Thiamine; Vitamins | 2021 |
Blood thiamine (vitamin B
Topics: Animals; Animals, Newborn; Ascorbic Acid; Horse Diseases; Horses; Hydrocortisone; Prospective Studie | 2021 |
Non-clinical safety profile and pharmacodynamics of two formulations of the anti-sepsis drug candidate Rejuveinix (RJX).
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Dr | 2021 |
The relationship between vitamin C or thiamine levels and outcomes for severe sepsis patients admitted to the ICU.
Topics: Ascorbic Acid; Female; Hospital Mortality; Hospitalization; Humans; Intensive Care Units; Male; Midd | 2021 |
Ex Vivo Evaluation of the Sepsis Triple Therapy High-Dose Vitamin C in Combination with Vitamin B1 and Hydrocortisone in a Human Peripheral Blood Mononuclear Cells (PBMCs) Model.
Topics: Adult; Anti-Inflammatory Agents; Ascorbic Acid; Cells, Cultured; Cytokines; Drug Therapy, Combinatio | 2021 |
How to Give Vitamin C a Cautious but Fair Chance in Severe Sepsis.
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2017 |
The Magic Bullet in Sepsis or the Inflation of Chance Findings?
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2017 |
Response.
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2017 |
Vitamin C in Sepsis: When It Seems Too Sweet, It Might (Literally) Be.
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2017 |
Vitamin C Is Not Ready for Prime Time in Sepsis but a Solution Is Close.
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2017 |
The Unsung Hero: Role of Thiamine in the 'Vitamin C Cocktail'.
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2017 |
Thiamine: Why No Chance in Severe Sepsis?
Topics: Ascorbic Acid; Humans; Sepsis; Thiamine; Vitamin B Complex | 2017 |
Response.
Topics: Humans; Probability; Sepsis; Thiamine | 2017 |
Response.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Sepsis; Thiamine; Vitamins | 2017 |
Hydrocortisone, Vitamin C and Thiamine for Sepsis: Whither the Ethics in Research?
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2017 |
Vitamin C and Sepsis: Framing the Postpublication Discussion.
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2017 |
Effect of Thiamine Administration on Lactate Clearance and Mortality in Patients With Septic Shock.
Topics: Adult; Aged; Cohort Studies; Critical Illness; Female; Follow-Up Studies; Humans; Intensive Care Uni | 2018 |
Glucometry When Using Vitamin C in Sepsis: A Note of Caution.
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2018 |
Response.
Topics: Ascorbic Acid; Controlled Before-After Studies; Humans; Hydrocortisone; Retrospective Studies; Sepsi | 2018 |
Adjunctive Therapies in the Management of Septic Shock.
Topics: Alcohol-Related Disorders; Humans; Pilot Projects; Sepsis; Shock, Septic; Thiamine | 2019 |
Procalcitonin is an essential biomarker for hydrocortisone, ascorbic acid, and thiamine (HAT) therapy in patients with sepsis.
Topics: Ascorbic Acid; Biomarkers; Humans; Hydrocortisone; Procalcitonin; Sepsis; Thiamine | 2019 |
Hydrocortisone, Ascorbic Acid, and Thiamine (HAT) Therapy Decreases Oxidative Stress, Improves Cardiovascular Function, and Improves Survival in Murine Sepsis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Blood Pressure; Disease Models, Anim | 2020 |
Ascorbic Acid, Thiamine, and Steroids in Septic Shock: Propensity Matched Analysis.
Topics: Ascorbic Acid; Humans; Hydrocortisone; Intensive Care Units; Retrospective Studies; Sepsis; Shock, S | 2020 |
Vitamin C administration in the critically ill: a summary of recent meta-analyses.
Topics: Ascorbic Acid; Controlled Before-After Studies; Critical Illness; Humans; Hydrocortisone; Retrospect | 2019 |
Inhibition of Intestinal Thiamin Transport in Rat Model of Sepsis.
Topics: Animals; Disease Models, Animal; Gastrointestinal Absorption; Intestinal Mucosa; Membrane Transport | 2016 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study.
Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Aged; Anti-Inflammatory Agents; Antioxidant | 2017 |
Modulation of the Redox Expression and Inflammation Response in the Critically Ill Polytrauma Patient with Thoracic Injury. Statistical Correlations between Antioxidant Therapy.
Topics: Abbreviated Injury Scale; Acetylcysteine; Adult; Aged; Antioxidants; Ascorbic Acid; Critical Illness | 2016 |
[Experiment on the immediate influence of vitamin B1 on nerve centers in septic complications following gunshot wounds].
Topics: Humans; Nervous System; Nervous System Physiological Phenomena; Sepsis; Thiamine; Wound Infection; W | 1946 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Thiamine deficiency in critically ill patients with sepsis.
Topics: Acidosis, Lactic; Adult; Critical Illness; Female; Humans; Male; Middle Aged; Prospective Studies; S | 2010 |
Low blood thiamine concentrations in children upon admission to the intensive care unit: risk factors and prognostic significance.
Topics: C-Reactive Protein; Child; Child, Preschool; Cohort Studies; Female; Humans; Infant; Intensive Care | 2011 |
[THIAMINE CONTENT OF THE ORGANS IN DIFFERENT DISEASES].
Topics: Adolescent; Anemia; Anemia, Aplastic; Child; Histocytochemistry; Humans; Infant; Infant Nutrition Di | 1963 |