thiamine has been researched along with Alloxan Diabetes in 46 studies
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the effect of thiamine disulfide (TD) on the pancreas in terms of hyperglycemia improvement and insulin sensitivity increase in diabetic male rats." | 8.12 | The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide. ( Meamar, R; Rad, MG; Sharifi, M; Soltani, N, 2022) |
| "The present study investigated the effect of thiamine disulfide (TD) on the pancreas in terms of hyperglycemia improvement and insulin sensitivity increase in diabetic male rats." | 4.12 | The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide. ( Meamar, R; Rad, MG; Sharifi, M; Soltani, N, 2022) |
| "To determine the effect of high dose thiamine on dyslipidemia in diabetic rats." | 3.75 | Effect of thiamine on lipid profile in diabetic rats. ( Ahmad, I; Malik, MM; Naveed, AK; Qamar, T; Raheem, A, 2009) |
| "Adenosine thiamine triphosphate (AThTP) is a nucleotide discovered in bacteria and some other living organisms more than a decade ago." | 1.72 | Synthesis, physico-chemical properties and effect of adenosine thiamine triphosphate on vitamin B ( Kolas, IK; Kudyrka, TG; Luchko, TA; Makar, AA; Makarchikov, AF; Rusina, IM; Usanov, SA; Yantsevich, AV, 2022) |
| "Thiamine treatment reduced plasma and tissue MDA levels, serum glucose, total cholesterol and triglyceride levels, and increased serum high density lipoprotein- cholesterol and insulin levels, serum PON and AE, erythrocyte SOD and blood GSH-Px activities." | 1.56 | Effects of thiamine treatment on oxidative stress in experimental diabetes. ( Dirican, M; Sarandol, E; Serdar, Z; Tas, S, 2020) |
| "Treatment with fenofibrate normalizes the altered lipid profile in diabetic rats, whereas benfotiamine treatment has no effect on lipid alteration in diabetic rats." | 1.35 | Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat. ( Balakumar, P; Chakkarwar, VA; Singh, M, 2009) |
| "Neuropathic pain was induced by either ligation of left L5/L6 spinal nerves or administration of streptozotocin (50 mg/kg, i." | 1.33 | Benfotiamine relieves inflammatory and neuropathic pain in rats. ( Caram-Salas, NL; Granados-Soto, V; Medina-Santillán, R; Reyes-García, G; Rocha-González, HI; Sánchez-Ramírez, GM; Vidal-Cantú, GC, 2006) |
| "Thiamine was given 50 mg/kg/day." | 1.33 | Protective effect of high-dose thiamine (B1) on rat detrusor contractility in streptozotocin-induced diabetes mellitus. ( Aydin, Y; Erkul, A; Ozçifçi, M; Turgut, M; Uzuner, K; Yenilmez, A, 2006) |
| "Treatment with thiamine did not significantly affect AGE or cmL levels." | 1.31 | Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats. ( Bitsch, I; Bretzel, RG; Federlin, KF; Geyer, J; Hammes, HP; Köpcke, W; Mavrakis, K; Netzel, M; Sauerland, C; Stracke, H; Werkmann, D, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (36.96) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (30.43) | 29.6817 |
| 2010's | 11 (23.91) | 24.3611 |
| 2020's | 4 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Makarchikov, AF | 1 |
| Kudyrka, TG | 1 |
| Luchko, TA | 1 |
| Yantsevich, AV | 1 |
| Rusina, IM | 1 |
| Makar, AA | 1 |
| Kolas, IK | 1 |
| Usanov, SA | 1 |
| Rad, MG | 1 |
| Sharifi, M | 1 |
| Meamar, R | 1 |
| Soltani, N | 1 |
| Ghaiad, HR | 1 |
| Ali, SO | 1 |
| Al-Mokaddem, AK | 1 |
| Abdelmonem, M | 1 |
| Sarandol, E | 1 |
| Tas, S | 1 |
| Serdar, Z | 1 |
| Dirican, M | 1 |
| Amiri, A | 1 |
| Dehkordi, RAF | 1 |
| Heidarnejad, MS | 1 |
| Dehkordi, MJ | 1 |
| Liang, X | 1 |
| Yee, SW | 1 |
| Chien, HC | 1 |
| Chen, EC | 1 |
| Luo, Q | 1 |
| Zou, L | 1 |
| Piao, M | 1 |
| Mifune, A | 1 |
| Chen, L | 1 |
| Calvert, ME | 1 |
| King, S | 1 |
| Norheim, F | 1 |
| Abad, J | 1 |
| Krauss, RM | 1 |
| Giacomini, KM | 1 |
| Nacitarhan, C | 1 |
| Minareci, E | 1 |
| Sadan, G | 1 |
| Jung, KH | 1 |
| Lee, JH | 1 |
| Park, JW | 1 |
| Paik, JY | 1 |
| Quach, CH | 1 |
| Lee, EJ | 1 |
| Lee, KH | 1 |
| Joseph, D | 1 |
| Essop, MF | 1 |
| Ahmed El-Shazly, S | 1 |
| Ahmed, MM | 1 |
| Ibrahim, ZS | 1 |
| Refat, MS | 1 |
| Kohda, Y | 1 |
| Shirakawa, H | 1 |
| Yamane, K | 1 |
| Otsuka, K | 1 |
| Kono, T | 1 |
| Terasaki, F | 1 |
| Tanaka, T | 1 |
| Balakumar, P | 1 |
| Chakkarwar, VA | 1 |
| Singh, M | 1 |
| JANES, RG | 2 |
| BRADY, J | 1 |
| Naveed, AK | 1 |
| Qamar, T | 1 |
| Ahmad, I | 1 |
| Raheem, A | 1 |
| Malik, MM | 1 |
| Katare, RG | 1 |
| Caporali, A | 1 |
| Oikawa, A | 2 |
| Meloni, M | 2 |
| Emanueli, C | 3 |
| Madeddu, P | 3 |
| BRADY, JM | 1 |
| Karachalias, N | 4 |
| Babaei-Jadidi, R | 4 |
| Rabbani, N | 2 |
| Thornalley, PJ | 5 |
| Du, Y | 1 |
| Kowluru, A | 1 |
| Kern, TS | 1 |
| Katare, R | 1 |
| Cesselli, D | 1 |
| Beltrami, AP | 1 |
| Avolio, E | 1 |
| Muthukrishnan, D | 1 |
| Munasinghe, PE | 1 |
| Angelini, G | 1 |
| Hammes, HP | 2 |
| Du, X | 1 |
| Edelstein, D | 1 |
| Taguchi, T | 1 |
| Matsumura, T | 1 |
| Ju, Q | 1 |
| Lin, J | 1 |
| Bierhaus, A | 1 |
| Nawroth, P | 1 |
| Hannak, D | 1 |
| Neumaier, M | 1 |
| Bergfeld, R | 1 |
| Giardino, I | 1 |
| Brownlee, M | 1 |
| Ahmed, N | 3 |
| Battah, S | 1 |
| FOA, PP | 1 |
| WEINSTEIN, HR | 1 |
| SMITH, JA | 1 |
| GREENBERG, M | 1 |
| DE BASTIANI, G | 1 |
| PERISSINOTTO, B | 1 |
| ZATTI, P | 1 |
| Roux, H | 1 |
| JacquetFrancillon, ML | 1 |
| MACHIDA, K | 2 |
| SILIPRANDI, D | 1 |
| SILIPRANDI, N | 1 |
| Kupich, C | 2 |
| Ceylan-Isik, AF | 1 |
| Wu, S | 2 |
| Li, Q | 1 |
| Li, SY | 1 |
| Ren, J | 2 |
| Sánchez-Ramírez, GM | 1 |
| Caram-Salas, NL | 1 |
| Rocha-González, HI | 1 |
| Vidal-Cantú, GC | 1 |
| Medina-Santillán, R | 1 |
| Reyes-García, G | 1 |
| Granados-Soto, V | 1 |
| Gadau, S | 1 |
| Van Linthout, S | 1 |
| Graiani, G | 1 |
| Todaro, M | 1 |
| Campesi, I | 1 |
| Invernici, G | 1 |
| Spillmann, F | 1 |
| Ward, K | 1 |
| Yenilmez, A | 1 |
| Ozçifçi, M | 1 |
| Aydin, Y | 1 |
| Turgut, M | 1 |
| Uzuner, K | 1 |
| Erkul, A | 1 |
| BRADA, Z | 1 |
| ABELIN, I | 1 |
| Hobara, R | 1 |
| Kato, H | 1 |
| Sakamoto, K | 1 |
| Stracke, H | 1 |
| Werkmann, D | 1 |
| Mavrakis, K | 1 |
| Bitsch, I | 1 |
| Netzel, M | 1 |
| Geyer, J | 1 |
| Köpcke, W | 1 |
| Sauerland, C | 1 |
| Bretzel, RG | 1 |
| Federlin, KF | 1 |
| Scaffidi, L | 1 |
| Rotolo, G | 1 |
| Scaffidi, A | 1 |
| Berant, M | 1 |
| Berkovitz, D | 1 |
| Mandel, H | 1 |
| Zinder, O | 1 |
| Mordohovich, D | 1 |
| Miyoshi, T | 1 |
| Goto, I | 1 |
| Machii, B | 1 |
| Cappelli, V | 2 |
| Ceriani, T | 2 |
| Panagia, V | 2 |
| Deptula, S | 1 |
| Paczek, K | 1 |
| Tautt, J | 1 |
| Stroev', EA | 1 |
| Ukhov, IuI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318] | Phase 4 | 86 participants (Anticipated) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thiamine and Alloxan Diabetes
| Article | Year |
|---|---|
Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropat | 2011 |
45 other studies available for thiamine and Alloxan Diabetes
| Article | Year |
|---|---|
Synthesis, physico-chemical properties and effect of adenosine thiamine triphosphate on vitamin B
Topics: Adenosine Triphosphate; Alloxan; Animals; Diabetes Mellitus, Experimental; Liver; Mammals; Rats; Thi | 2022 |
The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Hyperglycemia; Insulin; Male; Pan | 2022 |
Regulation of PKC/TLR-4/NF-kB signaling by sulbutiamine improves diabetic nephropathy in rats.
Topics: Animals; Anti-Inflammatory Agents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; | 2023 |
Effects of thiamine treatment on oxidative stress in experimental diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Malondialdehyde; Oxidative St | 2020 |
Effect of the Zinc Oxide Nanoparticles and Thiamine for the Management of Diabetes in Alloxan-Induced Mice: a Stereological and Biochemical Study.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Lipids; Mice; Mice, Inbred | 2018 |
Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
Topics: Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Diabete | 2018 |
The effect of benfotiamine on mu-opioid receptor mediated antinociception in experimental diabetes.
Topics: Analgesics; Analgesics, Opioid; Animals; Body Weight; Diabetes Mellitus, Experimental; Fentanyl; For | 2014 |
Annexin V imaging detects diabetes-accelerated apoptosis and monitors the efficacy of benfotiamine treatment in ischemic limbs of mice.
Topics: Animals; Annexin A5; Apoptosis; Cell Line, Tumor; Diabetes Mellitus, Experimental; Hindlimb; Ischemi | 2014 |
The effects of thiamine treatment on pre-diabetic versus overt diabetic rat hearts: role of non-oxidative glucose pathways.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Male; Oxidation-Reduction; Prediabetic State; Ran | 2014 |
Synthesis, characterization, and efficacy evaluation of a new anti-diabetic vanadyl(II) thiamine hydrochloride complex in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; Liver; Male; | 2015 |
Prevention of incipient diabetic cardiomyopathy by high-dose thiamine.
Topics: Animals; Blood Glucose; Cardiomyopathies; Diabetes Mellitus, Experimental; Fibrosis; Glycosylation; | 2008 |
Ameliorative effect of combination of benfotiamine and fenofibrate in diabetes-induced vascular endothelial dysfunction and nephropathy in the rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Chelating Agents; Diabetes Mellitu | 2009 |
Thiamine deficiency in normal rats and in rats made diabetic with alloxan.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Rats; Thiamine; Thiamine Deficiency | 1948 |
Effect of thiamine on lipid profile in diabetic rats.
Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Dyslipidemias; Hyperglycemia; Lipi | 2009 |
Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway.
Topics: Analysis of Variance; Animals; Apoptosis; Blood Flow Velocity; Blotting, Western; Carrier Proteins; | 2010 |
Thiamine deficiency in adult normal and diabetic rats as studied under paired-feeding conditions.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet; Feeding and Eating Disorders; Rat | 1947 |
Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes.
Topics: Adjuvants, Immunologic; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Kidney Glo | 2010 |
PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine.
Topics: Analysis of Variance; Animals; Aorta; Blotting, Western; Cattle; Cell Death; Cells, Cultured; Diabet | 2010 |
Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes.
Topics: Animals; Antigens, CD; Antigens, Ly; Apoptosis; Biomarkers; Blood Glucose; Cell Proliferation; Cell | 2013 |
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Topics: Animals; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelium | 2003 |
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.
Topics: Albuminuria; Animals; Chelating Agents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dos | 2003 |
Effects of insulin on thiamine phosphorylation and dephosphorylation in liver homogenates of normal, thiamine-deficient, and alloxan-diabetic rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Insulin; Liver; Phosphorylation; Rats; Thiamine; | 1952 |
[Vitamin B1 and alloxan diabetes in rabbit].
Topics: Animals; Diabetes Mellitus, Experimental; Rabbits; Thiamine | 1952 |
[On the biochemical action of polyphosphoric amide esters of aneurine and sodium polyphosphates. VII. Polyphosphoric amide esters and alloxanic diabetes].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Thiamine | 1955 |
The effect of thiamine on the content of insulin-like substance in mouse serum.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Insulin; Mice; Muscles; Thiamine; Thiamine Defici | 1956 |
The effect of thiamine on the content of insulin-like substance in mouse serum.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Insulin; Mice; Muscles; Thiamine; Thiamine Defici | 1956 |
The effect of thiamine on the content of insulin-like substance in mouse serum.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Insulin; Mice; Muscles; Thiamine; Thiamine Defici | 1956 |
The effect of thiamine on the content of insulin-like substance in mouse serum.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose; Insulin; Mice; Muscles; Thiamine; Thiamine Defici | 1956 |
Action of insulin on thiamine phosphorylation.
Topics: Animals; Diabetes Mellitus, Experimental; Insulin; Phosphorylation; Thiamine; Vitamin B Complex; Vit | 1952 |
[Diabetes mellitus. Retinal lesions should not exist!].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme Activation; Glycated Hemoglob | 2004 |
High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats.
Topics: Animals; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Experimental; Hyperlipidemias; Insulin; R | 2004 |
High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Complications; Diabetes Mellitus, Experimental; Gly | 2005 |
High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus.
Topics: Adjuvants, Immunologic; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Rel | 2006 |
Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of advanced glycation end-product, tissue factor and TNF-alpha.
Topics: Adjuvants, Immunologic; Analysis of Variance; Animals; Blood Glucose; Diabetes Mellitus, Experimenta | 2006 |
Benfotiamine relieves inflammatory and neuropathic pain in rats.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Diabetes Mellitus, Experimental; Dose-Respons | 2006 |
Benfotiamine accelerates the healing of ischaemic diabetic limbs in mice through protein kinase B/Akt-mediated potentiation of angiogenesis and inhibition of apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Body Weight; Caspase 3; Caspase Inhibitors; Caspases; Cell Pr | 2006 |
Protective effect of high-dose thiamine (B1) on rat detrusor contractility in streptozotocin-induced diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Carbachol; Diabetes Mellitus, Experimental; Diuresis; Male; Mus | 2006 |
About the Influence of the B1 Vitamin on the sugar turnover in alloxan diabetes.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Thiamine | 1948 |
Effect of thiamine and thiamine levels on experimental alloxan induced diabetes mellitus.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diet; Male; Mice; Mice, Inbred | 1983 |
Efficacy of benfotiamine versus thiamine on function and glycation products of peripheral nerves in diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Glycosyla | 2001 |
[Research on the possible protective action of ascorbic acid, thiamine and cyanocobalamin on testicular damage in alloxan diabetes in the rat].
Topics: Animals; Ascorbic Acid; Diabetes Mellitus, Experimental; Male; Rats; Testicular Diseases; Testis; Th | 1979 |
Thiamin status of the offspring of diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Erythrocytes; Female; Insulin; Pregnancy; P | 1988 |
Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes.
Topics: Animals; Body Temperature; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, A | 1973 |
[Experimental studies on the effects of various vitamins on blood sugar in rats and the mechanism of action].
Topics: Animals; Ascorbic Acid; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Flavono | 1966 |
[Endocrine factors and metabolism of thiamine. I. Uptake and phosphorylation of thiamine in the liver of rats with alloxan diabetes and pancreatectomy].
Topics: Animals; Diabetes Mellitus, Experimental; Liver; Pancreas; Pancreatectomy; Rats; Thiamine | 1972 |
[Endocrine factors and metabolism of thiamine. I. Effect of adrenalectomy on the uptake and phosphorylation of thiamine in the liver of (alloxan) diabetic and nondiabetic rats]].
Topics: Adrenal Glands; Adrenalectomy; Animals; Diabetes Mellitus, Experimental; Liver; Rats; Thiamine | 1972 |
[Determination of the content of some vitamins, pyruvic acid or degree of acetylation in rabbits in alloxan hyperglycemia].
Topics: Animals; Ascorbic Acid; Diabetes Mellitus, Experimental; Kidney; Liver; Male; Pyruvates; Rabbits; Th | 1969 |
[On the metabolism of the myocardium in alloxan diabetes and in combination with thyroxine toxicosis or hypothyrosis].
Topics: Animals; Citrates; Coenzyme A; Diabetes Mellitus, Experimental; Histocytochemistry; Hyperthyroidism; | 1969 |