Page last updated: 2024-10-20

thiamine and Albuminuria

thiamine has been researched along with Albuminuria in 13 studies

thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.

Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.

Research Excerpts

ExcerptRelevanceReference
"High-dose supplements of thiamine prevent the development of microalbuminuria in experimental diabetes."9.14High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. ( Akhtar, MW; Alam, SS; Larkin, JR; Rabbani, N; Riaz, S; Shafi, T; Thornalley, PJ, 2009)
"Thiamine deficiency has been linked to microvascular complications in patients with diabetes mellitus (DM)."5.38Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria. ( Abd-Alrahman, SH; Al-Attas, OS; Al-Daghri, NM; Alfadda, AA; Sabico, S, 2012)
"High-dose supplements of thiamine prevent the development of microalbuminuria in experimental diabetes."5.14High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study. ( Akhtar, MW; Alam, SS; Larkin, JR; Rabbani, N; Riaz, S; Shafi, T; Thornalley, PJ, 2009)
" Thiamine was found to be beneficial for reduction in albuminuria in a single study; however, there was lack of any improvement in kidney function or blood pressure following the use of vitamin B preparations used alone or in combination."4.91Vitamin B and its derivatives for diabetic kidney disease. ( Gor, D; Rangoonwala, AN; Raval, AD; Thakker, D; Walia, R, 2015)
"Thiamine (vitamin B1) is an essential cofactor in glucose metabolism, but it remains unclear whether thiamine status is lower in individuals with diabetes compared to individuals with normal glucose metabolism."3.01Association between diabetes and thiamine status - A systematic review and meta-analysis. ( Obeid, R; Reiners, K; Strom, A; Ziegler, D, 2023)
"Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to 12 weeks of benfotiamine (900 mg/day) (n = 39) or placebo (n = 43)."2.75A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy. ( Achenbach, U; Alkhalaf, A; Bakker, SJ; Bilo, HJ; Gans, RO; Kleefstra, N; Klooster, A; Mijnhout, GS; Navis, GJ; Slingerland, RJ; van Oeveren, W, 2010)
"Thiamine deficiency was highly prevalent in all groups, whereas low vitamin B₁₂ and elevated methylmalonic acid were rare."1.42Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. ( Bangert, V; Hostalek, U; Kaiser, RP; Nix, WA; Obeid, R; Schilling, M; Zirwes, R, 2015)
"Thiamine deficiency has been linked to microvascular complications in patients with diabetes mellitus (DM)."1.38Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria. ( Abd-Alrahman, SH; Al-Attas, OS; Al-Daghri, NM; Alfadda, AA; Sabico, S, 2012)
"One hundred and fifteen patients with type 2 diabetes with and without microalbuminuria or albuminuria and 39 healthy people were recruited."1.38Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation. ( Adaikalakoteswari, A; Adam, JM; Kariadi, SH; Rabbani, N; Thornalley, PJ; Tjokroprawiro, A; Waspadji, S, 2012)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (30.77)29.6817
2010's8 (61.54)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Ziegler, D1
Reiners, K1
Strom, A1
Obeid, R2
Nix, WA1
Zirwes, R1
Bangert, V1
Kaiser, RP1
Schilling, M1
Hostalek, U1
Raval, AD1
Thakker, D1
Rangoonwala, AN1
Gor, D1
Walia, R1
Rabbani, N4
Alam, SS1
Riaz, S2
Larkin, JR1
Akhtar, MW1
Shafi, T1
Thornalley, PJ6
Alkhalaf, A2
Kleefstra, N2
Groenier, KH1
Bakker, SJ2
Navis, GJ2
Bilo, HJ2
Klooster, A1
van Oeveren, W1
Achenbach, U1
Slingerland, RJ1
Mijnhout, GS1
Gans, RO1
Skinner, V1
Srai, SK1
Kihm, LP1
Müller-Krebs, S1
Klein, J1
Ehrlich, G1
Mertes, L1
Gross, ML1
Adaikalakoteswari, A2
Hammes, HP1
Nawroth, PP1
Zeier, M1
Schwenger, V1
Al-Attas, OS1
Al-Daghri, NM1
Alfadda, AA1
Abd-Alrahman, SH1
Sabico, S1
Waspadji, S1
Tjokroprawiro, A1
Kariadi, SH1
Adam, JM1
Babaei-Jadidi, R2
Karachalias, N1
Ahmed, N1
Battah, S1
Al Ali, H1
Antonysunil, A1
Larkin, J1
Ahmed, A1
Rayman, G1
Bodmer, CW1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Vitamin B Status in Type 2 Diabetes (VITA) Study[NCT03447275]174 participants (Actual)Observational2011-01-31Completed
A Double-Blind Clinical Trial of Benfotiamine Treatment in Diabetic Nephropathy[NCT00565318]Phase 486 participants (Anticipated)Interventional2007-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for thiamine and Albuminuria

ArticleYear
Association between diabetes and thiamine status - A systematic review and meta-analysis.
    Metabolism: clinical and experimental, 2023, Volume: 144

    Topics: Albuminuria; Diabetes Mellitus; Glucose; Humans; Thiamine; Thiamine Pyrophosphate

2023
Vitamin B and its derivatives for diabetic kidney disease.
    The Cochrane database of systematic reviews, 2015, Jan-12, Volume: 1

    Topics: Albuminuria; Diabetic Nephropathies; Folic Acid; Humans; Pyridoxamine; Randomized Controlled Trials

2015
Emerging role of thiamine therapy for prevention and treatment of early-stage diabetic nephropathy.
    Diabetes, obesity & metabolism, 2011, Volume: 13, Issue:7

    Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropat

2011

Trials

3 trials available for thiamine and Albuminuria

ArticleYear
High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study.
    Diabetologia, 2009, Volume: 52, Issue:2

    Topics: Albuminuria; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Glomerular Filtration R

2009
A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy.
    Diabetes care, 2010, Volume: 33, Issue:7

    Topics: Adjuvants, Immunologic; Adult; Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotens

2010
Effect of high dose thiamine on the levels of urinary protein biomarkers in diabetes mellitus type 2.
    Journal of pharmaceutical and biomedical analysis, 2011, Mar-25, Volume: 54, Issue:4

    Topics: Adult; Aged; Albuminuria; Biomarkers; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type

2011

Other Studies

7 other studies available for thiamine and Albuminuria

ArticleYear
Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.
    Diabetes research and clinical practice, 2015, Volume: 107, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Albuminuria; Biomarkers; Case-Control Studies; Diabetes Mellitus, Ty

2015
Thiamine in diabetic nephropathy: a novel treatment modality?
    Diabetologia, 2009, Volume: 52, Issue:6

    Topics: Albuminuria; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glycated Hemoglobin;

2009
Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis.
    Journal of the American Society of Nephrology : JASN, 2011, Volume: 22, Issue:5

    Topics: Albuminuria; Animals; Fibrosis; Glycation End Products, Advanced; Kidney; Male; Peritoneal Dialysis;

2011
Blood thiamine and its phosphate esters as measured by high-performance liquid chromatography: levels and associations in diabetes mellitus patients with varying degrees of microalbuminuria.
    Journal of endocrinological investigation, 2012, Volume: 35, Issue:11

    Topics: Adolescent; Adult; Aged; Albuminuria; Blood Glucose; Child; Child, Preschool; Cholesterol; Chromatog

2012
Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation.
    Diabetes research and clinical practice, 2012, Volume: 95, Issue:3

    Topics: Albuminuria; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Indonesia; In

2012
Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine.
    Diabetes, 2003, Volume: 52, Issue:8

    Topics: Albuminuria; Animals; Chelating Agents; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dos

2003
High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease.
    Diabetologia, 2007, Volume: 50, Issue:10

    Topics: Albuminuria; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies

2007