theophylline has been researched along with Syncope in 23 studies
Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, both acute electrophysiologic actions of intravenously administered theophylline and clinical effects of chronic oral theophylline therapy were assessed in 10 young patients (aged 9 to 41 years) without clinically significant cardiac disease, in whom recurrent symptoms of syncope and dizziness were attributed to transient bradyarrhythmias (sinus pauses, marked sinus bradycardia or paroxysmal atrioventricular [AV] block)." | 9.05 | Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. ( Benditt, DG; Benson, DW; Crouse, L; Dunnigan, A; Kreitt, J; Pritzker, MR; Scheinman, MM, 1983) |
| "Theophylline was effective in preventing recurrences in patients with syncope without prodromes, normal heart, and normal ECG." | 8.12 | Theophylline in patients with syncope without prodrome, normal heart, and normal electrocardiogram: a propensity-score matched study verified by implantable cardiac monitor. ( Brignole, M; Carretta, D; Deharo, JC; Guieu, R; Iori, M; Napoli, P; Rivasi, G; Solari, D; Strano, S; Tomaino, M; Ungar, A, 2022) |
| "In a consecutive case-series of 16 patients (mean age 47 ± 25 years, 9 females) who had ECG documentation of asystolic syncope, we compared the incidence of syncopal recurrence during a period without and a period with tailored theophylline therapy." | 7.91 | Efficacy of theophylline in patients with syncope without prodromes with normal heart and normal ECG. ( Bottoni, N; Brignole, M; Deharo, JC; Guieu, R; Iori, M; Rivasi, G; Solari, D; Ungar, A, 2019) |
| "In patients with symptomatic SSS, therapy with theophylline or dual-chamber pacemaker is associated with a lower incidence of heart failure; pacemaker therapy is also associated with a lower incidence of syncope." | 5.08 | Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial. ( Alboni, P; Brignole, M; Cappato, R; Gaggioli, G; Lolli, G; Menozzi, C; Paparella, N, 1997) |
| "To study the efficacy of medical treatment for preventing syncopal recurrences in patients affected by tilt-induced neurally mediated syncope, a randomized placebo-treatment prospective study was performed in 30 patients (10 men and 20 women, mean age 42 +/- 21 years) who had syncope reproduced in 2 consecutive head-up tilt-table tests without pharmacologic intervention (n = 20) or during isoproterenol infusion (n = 10)." | 5.07 | A controlled trial of acute and long-term medical therapy in tilt-induced neurally mediated syncope. ( Bottoni, N; Brignole, M; Gianfranchi, L; Lolli, G; Menozzi, C; Oddone, D, 1992) |
| "In this study, both acute electrophysiologic actions of intravenously administered theophylline and clinical effects of chronic oral theophylline therapy were assessed in 10 young patients (aged 9 to 41 years) without clinically significant cardiac disease, in whom recurrent symptoms of syncope and dizziness were attributed to transient bradyarrhythmias (sinus pauses, marked sinus bradycardia or paroxysmal atrioventricular [AV] block)." | 5.05 | Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. ( Benditt, DG; Benson, DW; Crouse, L; Dunnigan, A; Kreitt, J; Pritzker, MR; Scheinman, MM, 1983) |
| "Theophylline was effective in preventing recurrences in patients with syncope without prodromes, normal heart, and normal ECG." | 4.12 | Theophylline in patients with syncope without prodrome, normal heart, and normal electrocardiogram: a propensity-score matched study verified by implantable cardiac monitor. ( Brignole, M; Carretta, D; Deharo, JC; Guieu, R; Iori, M; Napoli, P; Rivasi, G; Solari, D; Strano, S; Tomaino, M; Ungar, A, 2022) |
| "In a consecutive case-series of 16 patients (mean age 47 ± 25 years, 9 females) who had ECG documentation of asystolic syncope, we compared the incidence of syncopal recurrence during a period without and a period with tailored theophylline therapy." | 3.91 | Efficacy of theophylline in patients with syncope without prodromes with normal heart and normal ECG. ( Bottoni, N; Brignole, M; Deharo, JC; Guieu, R; Iori, M; Rivasi, G; Solari, D; Ungar, A, 2019) |
| "The purpose of this study was to gain insight into the mechanism of vasovagal syncope and to test the efficacy of theophylline to prevent syncope." | 3.69 | Excessive myocardial contraction in vasovagal syncope demonstrated by echocardiography during head-up tilt test. ( Chao, CL; Chen, MF; Lee, TM; Lee, YT; Liau, CS; Su, SF, 1996) |
| "If cardiac syncope is unlikely, reflex (neurally mediated) syncope and orthostatic hypotension are the most frequent causes of transient loss of consciousness." | 2.72 | New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope. ( Brignole, M; Rivasi, G, 2021) |
| "The underlying etiology of a syncopal episode remains not infrequently unknown despite intensive and sometimes costly diagnostic procedures." | 2.39 | [Neurocardiac syncope: pathophysiology, diagnosis, therapy]. ( Hohnloser, SH; Klingenheben, T, 1995) |
| " In our case, the theophylline dosage was approximately half the amount described in previous reports." | 1.62 | Severe pallid breath-holding spells treated with low-dose theophylline. ( Asakai, H; Oda, Y; Sato, A, 2021) |
| "No further syncope has occurred for 16 months during the therapy with theophyllin." | 1.29 | [Pre-syncope and syncope at the operating table--diagnostic and therapeutic possibilities]. ( Heck, KF; Hust, MH; Keim, MW, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 9 (39.13) | 18.2507 |
| 2000's | 1 (4.35) | 29.6817 |
| 2010's | 8 (34.78) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Brignole, M | 7 |
| Iori, M | 4 |
| Strano, S | 1 |
| Tomaino, M | 2 |
| Rivasi, G | 3 |
| Ungar, A | 3 |
| Carretta, D | 1 |
| Solari, D | 3 |
| Napoli, P | 1 |
| Deharo, JC | 3 |
| Guieu, R | 4 |
| Sato, A | 1 |
| Oda, Y | 1 |
| Asakai, H | 1 |
| Bottoni, N | 4 |
| Mitro, P | 1 |
| Carano, N | 1 |
| Bo, I | 1 |
| Zanetti, E | 1 |
| Tchana, B | 1 |
| Barbato, G | 1 |
| Agnetti, A | 1 |
| Vallurupalli, S | 1 |
| Aggarwal, C | 1 |
| Sewani, A | 1 |
| Paydak, H | 1 |
| Treseder, JR | 1 |
| Jung, S | 1 |
| La Rocca, R | 1 |
| Campedel, F | 1 |
| Materia, V | 1 |
| Saggese, MP | 1 |
| Patanè, S | 1 |
| Bertolone, C | 1 |
| Unterhuber, M | 1 |
| Tesi, F | 1 |
| Claude Deharo, J | 1 |
| BREATHNACH, CS | 1 |
| Park, HW | 1 |
| Cho, JG | 1 |
| Yum, JH | 1 |
| Hong, YJ | 1 |
| Lim, JH | 1 |
| Kim, HG | 1 |
| Kim, JH | 1 |
| Ahn, YK | 1 |
| Jeong, MH | 1 |
| Park, JC | 1 |
| Kang, JC | 1 |
| Benditt, DG | 1 |
| Benson, DW | 1 |
| Kreitt, J | 1 |
| Dunnigan, A | 1 |
| Pritzker, MR | 1 |
| Crouse, L | 1 |
| Scheinman, MM | 1 |
| Natale, A | 1 |
| Sra, J | 1 |
| Dhala, A | 2 |
| Wase, A | 1 |
| Jazayeri, M | 1 |
| Deshpande, S | 2 |
| Blanck, Z | 2 |
| Akhtar, M | 2 |
| Klingenheben, T | 1 |
| Hohnloser, SH | 1 |
| Sra, JS | 1 |
| Jazayeri, MR | 1 |
| Avitall, B | 1 |
| Keim, MW | 1 |
| Heck, KF | 1 |
| Hust, MH | 1 |
| Grubb, BP | 1 |
| Kosinski, D | 1 |
| Mouhaffel, A | 1 |
| Pothoulakis, A | 1 |
| Lee, TM | 1 |
| Chen, MF | 1 |
| Su, SF | 1 |
| Chao, CL | 1 |
| Liau, CS | 1 |
| Lee, YT | 1 |
| Alboni, P | 1 |
| Menozzi, C | 2 |
| Paparella, N | 1 |
| Gaggioli, G | 1 |
| Lolli, G | 2 |
| Cappato, R | 1 |
| Gianfranchi, L | 1 |
| Oddone, D | 1 |
| Nelson, SD | 1 |
| Stanley, M | 1 |
| Love, CJ | 1 |
| Coyne, KS | 1 |
| Schaal, SF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Theophylline in Patients With Unexplained Syncope and Low Adenosine. Study Verified by ICM, Controlled by Propensity-score Matching[NCT03803215] | 77 participants (Actual) | Observational | 2016-05-11 | Completed | |||
| Assessment of the Mechanism of Non-cardiac Syncope by 24-hour Ambulatory Blood Pressure Monitoring (ABPM) and Tilt-table Short Cardiovascular Autonomic Function Battery (SCAFB)[NCT05728255] | 275 participants (Anticipated) | Observational | 2023-04-30 | Not yet recruiting | |||
| Efficacy of Transcatheter Ablation of Ganglionic Plexuses (Cardioneuroablation) in Right Atrium in Patients With Asystolic Neuromediated Syncope[NCT05751330] | 24 participants (Anticipated) | Interventional | 2022-09-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for theophylline and Syncope
| Article | Year |
|---|---|
New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope.
Topics: Accidental Falls; Adenosine; Antihypertensive Agents; Atomoxetine Hydrochloride; Atrioventricular No | 2021 |
[Neurocardiac syncope: pathophysiology, diagnosis, therapy].
Topics: Adrenergic beta-Antagonists; Autonomic Nervous System; Diagnosis, Differential; Heart; Hemodynamics; | 1995 |
4 trials available for theophylline and Syncope
| Article | Year |
|---|---|
Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias.
Topics: Adolescent; Adult; Atrioventricular Node; Bradycardia; Cardiac Pacing, Artificial; Clinical Trials a | 1983 |
Efficacy of different treatment strategies for neurocardiogenic syncope.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Disopyramide; Ephedrine; Fe | 1995 |
Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial.
Topics: Administration, Oral; Aged; Atrial Fibrillation; Cardiac Output, Low; Female; Follow-Up Studies; Hea | 1997 |
A controlled trial of acute and long-term medical therapy in tilt-induced neurally mediated syncope.
Topics: Adult; Atenolol; Bandages; Dihydroergotamine; Domperidone; Female; Humans; Isoproterenol; Male; Midd | 1992 |
17 other studies available for theophylline and Syncope
| Article | Year |
|---|---|
Theophylline in patients with syncope without prodrome, normal heart, and normal electrocardiogram: a propensity-score matched study verified by implantable cardiac monitor.
Topics: Atrioventricular Block; Electrocardiography; Heart Arrest; Humans; Propensity Score; Recurrence; Syn | 2022 |
Severe pallid breath-holding spells treated with low-dose theophylline.
Topics: Apnea; Breath Holding; Dose-Response Relationship, Drug; Heart Arrest; Humans; Infant; Male; Seizure | 2021 |
Efficacy of theophylline in patients with syncope without prodromes with normal heart and normal ECG.
Topics: Adenosine; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Child; Dose-Response Relationship | 2019 |
Asystolic syncope - To pace or not to pace, that is the question.
Topics: Electrocardiography; Heart Arrest; Humans; Syncope; Theophylline | 2019 |
Glycopyrrolate and theophylline for the treatment of severe pallid breath-holding spells.
Topics: Apnea; Breath Holding; Female; Glycopyrrolate; Humans; Infant; Muscarinic Antagonists; Phosphodieste | 2013 |
Oral theophylline as temporizing treatment of neck mass induced carotid sinus syncope.
Topics: Administration, Oral; Head and Neck Neoplasms; Humans; Male; Middle Aged; Syncope; Theophylline; Tre | 2013 |
Efficacy of theophylline in patients affected by low adenosine syncope.
Topics: Adenosine; Adult; Aged; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Stu | 2016 |
ECG of the Month.
Topics: Animals; Dog Diseases; Dogs; Electrocardiography; Female; Pacemaker, Artificial; Sick Sinus Syndrome | 2016 |
Theophylline and syncope.
Topics: Adult; Atrioventricular Block; Bradycardia; Electrocardiography; Heart Rate; Humans; Male; Purinergi | 2016 |
Mechanism of syncope without prodromes with normal heart and normal electrocardiogram.
Topics: Aged; Atrioventricular Block; Cardiac Pacing, Artificial; Electrocardiography, Ambulatory; Female; H | 2017 |
COUGH SYNCOPE--THE MECHANISM IN TWO CASES.
Topics: Cough; Humans; Syncope; Theophylline; Toxicology | 1964 |
Clinical characteristics of hypervagotonic sinus node dysfunction.
Topics: Dizziness; Dyspnea; Female; Humans; Male; Middle Aged; Muscle Weakness; Sick Sinus Syndrome; Syncope | 2004 |
Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia or asystole.
Topics: Adolescent; Adult; Aged; Bradycardia; Cardiac Pacing, Artificial; Disopyramide; Female; Follow-Up St | 1993 |
[Pre-syncope and syncope at the operating table--diagnostic and therapeutic possibilities].
Topics: Adult; Diagnosis, Differential; General Surgery; Humans; Male; Occupational Diseases; Syncope; Theop | 1996 |
The use of methylphenidate in the treatment of refractory neurocardiogenic syncope.
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Bradycardia; Central Nervous S | 1996 |
Excessive myocardial contraction in vasovagal syncope demonstrated by echocardiography during head-up tilt test.
Topics: Adrenergic beta-Agonists; Adult; Aged; Analysis of Variance; Echocardiography; Female; Humans; Isopr | 1996 |
The autonomic and hemodynamic effects of oral theophylline in patients with vasodepressor syncope.
Topics: Administration, Oral; Adult; Autonomic Nervous System; Bradycardia; Female; Heart; Heart Rate; Human | 1991 |