Page last updated: 2024-10-22

theophylline and Syncope

theophylline has been researched along with Syncope in 23 studies

Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)

Research Excerpts

ExcerptRelevanceReference
"In this study, both acute electrophysiologic actions of intravenously administered theophylline and clinical effects of chronic oral theophylline therapy were assessed in 10 young patients (aged 9 to 41 years) without clinically significant cardiac disease, in whom recurrent symptoms of syncope and dizziness were attributed to transient bradyarrhythmias (sinus pauses, marked sinus bradycardia or paroxysmal atrioventricular [AV] block)."9.05Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. ( Benditt, DG; Benson, DW; Crouse, L; Dunnigan, A; Kreitt, J; Pritzker, MR; Scheinman, MM, 1983)
"Theophylline was effective in preventing recurrences in patients with syncope without prodromes, normal heart, and normal ECG."8.12Theophylline in patients with syncope without prodrome, normal heart, and normal electrocardiogram: a propensity-score matched study verified by implantable cardiac monitor. ( Brignole, M; Carretta, D; Deharo, JC; Guieu, R; Iori, M; Napoli, P; Rivasi, G; Solari, D; Strano, S; Tomaino, M; Ungar, A, 2022)
"In a consecutive case-series of 16 patients (mean age 47 ± 25 years, 9 females) who had ECG documentation of asystolic syncope, we compared the incidence of syncopal recurrence during a period without and a period with tailored theophylline therapy."7.91Efficacy of theophylline in patients with syncope without prodromes with normal heart and normal ECG. ( Bottoni, N; Brignole, M; Deharo, JC; Guieu, R; Iori, M; Rivasi, G; Solari, D; Ungar, A, 2019)
"In patients with symptomatic SSS, therapy with theophylline or dual-chamber pacemaker is associated with a lower incidence of heart failure; pacemaker therapy is also associated with a lower incidence of syncope."5.08Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial. ( Alboni, P; Brignole, M; Cappato, R; Gaggioli, G; Lolli, G; Menozzi, C; Paparella, N, 1997)
"To study the efficacy of medical treatment for preventing syncopal recurrences in patients affected by tilt-induced neurally mediated syncope, a randomized placebo-treatment prospective study was performed in 30 patients (10 men and 20 women, mean age 42 +/- 21 years) who had syncope reproduced in 2 consecutive head-up tilt-table tests without pharmacologic intervention (n = 20) or during isoproterenol infusion (n = 10)."5.07A controlled trial of acute and long-term medical therapy in tilt-induced neurally mediated syncope. ( Bottoni, N; Brignole, M; Gianfranchi, L; Lolli, G; Menozzi, C; Oddone, D, 1992)
"In this study, both acute electrophysiologic actions of intravenously administered theophylline and clinical effects of chronic oral theophylline therapy were assessed in 10 young patients (aged 9 to 41 years) without clinically significant cardiac disease, in whom recurrent symptoms of syncope and dizziness were attributed to transient bradyarrhythmias (sinus pauses, marked sinus bradycardia or paroxysmal atrioventricular [AV] block)."5.05Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. ( Benditt, DG; Benson, DW; Crouse, L; Dunnigan, A; Kreitt, J; Pritzker, MR; Scheinman, MM, 1983)
"Theophylline was effective in preventing recurrences in patients with syncope without prodromes, normal heart, and normal ECG."4.12Theophylline in patients with syncope without prodrome, normal heart, and normal electrocardiogram: a propensity-score matched study verified by implantable cardiac monitor. ( Brignole, M; Carretta, D; Deharo, JC; Guieu, R; Iori, M; Napoli, P; Rivasi, G; Solari, D; Strano, S; Tomaino, M; Ungar, A, 2022)
"In a consecutive case-series of 16 patients (mean age 47 ± 25 years, 9 females) who had ECG documentation of asystolic syncope, we compared the incidence of syncopal recurrence during a period without and a period with tailored theophylline therapy."3.91Efficacy of theophylline in patients with syncope without prodromes with normal heart and normal ECG. ( Bottoni, N; Brignole, M; Deharo, JC; Guieu, R; Iori, M; Rivasi, G; Solari, D; Ungar, A, 2019)
"The purpose of this study was to gain insight into the mechanism of vasovagal syncope and to test the efficacy of theophylline to prevent syncope."3.69Excessive myocardial contraction in vasovagal syncope demonstrated by echocardiography during head-up tilt test. ( Chao, CL; Chen, MF; Lee, TM; Lee, YT; Liau, CS; Su, SF, 1996)
"If cardiac syncope is unlikely, reflex (neurally mediated) syncope and orthostatic hypotension are the most frequent causes of transient loss of consciousness."2.72New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope. ( Brignole, M; Rivasi, G, 2021)
"The underlying etiology of a syncopal episode remains not infrequently unknown despite intensive and sometimes costly diagnostic procedures."2.39[Neurocardiac syncope: pathophysiology, diagnosis, therapy]. ( Hohnloser, SH; Klingenheben, T, 1995)
" In our case, the theophylline dosage was approximately half the amount described in previous reports."1.62Severe pallid breath-holding spells treated with low-dose theophylline. ( Asakai, H; Oda, Y; Sato, A, 2021)
"No further syncope has occurred for 16 months during the therapy with theophyllin."1.29[Pre-syncope and syncope at the operating table--diagnostic and therapeutic possibilities]. ( Heck, KF; Hust, MH; Keim, MW, 1996)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's9 (39.13)18.2507
2000's1 (4.35)29.6817
2010's8 (34.78)24.3611
2020's3 (13.04)2.80

Authors

AuthorsStudies
Brignole, M7
Iori, M4
Strano, S1
Tomaino, M2
Rivasi, G3
Ungar, A3
Carretta, D1
Solari, D3
Napoli, P1
Deharo, JC3
Guieu, R4
Sato, A1
Oda, Y1
Asakai, H1
Bottoni, N4
Mitro, P1
Carano, N1
Bo, I1
Zanetti, E1
Tchana, B1
Barbato, G1
Agnetti, A1
Vallurupalli, S1
Aggarwal, C1
Sewani, A1
Paydak, H1
Treseder, JR1
Jung, S1
La Rocca, R1
Campedel, F1
Materia, V1
Saggese, MP1
Patanè, S1
Bertolone, C1
Unterhuber, M1
Tesi, F1
Claude Deharo, J1
BREATHNACH, CS1
Park, HW1
Cho, JG1
Yum, JH1
Hong, YJ1
Lim, JH1
Kim, HG1
Kim, JH1
Ahn, YK1
Jeong, MH1
Park, JC1
Kang, JC1
Benditt, DG1
Benson, DW1
Kreitt, J1
Dunnigan, A1
Pritzker, MR1
Crouse, L1
Scheinman, MM1
Natale, A1
Sra, J1
Dhala, A2
Wase, A1
Jazayeri, M1
Deshpande, S2
Blanck, Z2
Akhtar, M2
Klingenheben, T1
Hohnloser, SH1
Sra, JS1
Jazayeri, MR1
Avitall, B1
Keim, MW1
Heck, KF1
Hust, MH1
Grubb, BP1
Kosinski, D1
Mouhaffel, A1
Pothoulakis, A1
Lee, TM1
Chen, MF1
Su, SF1
Chao, CL1
Liau, CS1
Lee, YT1
Alboni, P1
Menozzi, C2
Paparella, N1
Gaggioli, G1
Lolli, G2
Cappato, R1
Gianfranchi, L1
Oddone, D1
Nelson, SD1
Stanley, M1
Love, CJ1
Coyne, KS1
Schaal, SF1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Theophylline in Patients With Unexplained Syncope and Low Adenosine. Study Verified by ICM, Controlled by Propensity-score Matching[NCT03803215]77 participants (Actual)Observational2016-05-11Completed
Assessment of the Mechanism of Non-cardiac Syncope by 24-hour Ambulatory Blood Pressure Monitoring (ABPM) and Tilt-table Short Cardiovascular Autonomic Function Battery (SCAFB)[NCT05728255]275 participants (Anticipated)Observational2023-04-30Not yet recruiting
Efficacy of Transcatheter Ablation of Ganglionic Plexuses (Cardioneuroablation) in Right Atrium in Patients With Asystolic Neuromediated Syncope[NCT05751330]24 participants (Anticipated)Interventional2022-09-20Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for theophylline and Syncope

ArticleYear
New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope.
    Heart (British Cardiac Society), 2021, Volume: 107, Issue:11

    Topics: Accidental Falls; Adenosine; Antihypertensive Agents; Atomoxetine Hydrochloride; Atrioventricular No

2021
[Neurocardiac syncope: pathophysiology, diagnosis, therapy].
    Zeitschrift fur Kardiologie, 1995, Volume: 84, Issue:2

    Topics: Adrenergic beta-Antagonists; Autonomic Nervous System; Diagnosis, Differential; Heart; Hemodynamics;

1995

Trials

4 trials available for theophylline and Syncope

ArticleYear
Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias.
    The American journal of cardiology, 1983, Dec-01, Volume: 52, Issue:10

    Topics: Adolescent; Adult; Atrioventricular Node; Bradycardia; Cardiac Pacing, Artificial; Clinical Trials a

1983
Efficacy of different treatment strategies for neurocardiogenic syncope.
    Pacing and clinical electrophysiology : PACE, 1995, Volume: 18, Issue:4 Pt 1

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Disopyramide; Ephedrine; Fe

1995
Effects of permanent pacemaker and oral theophylline in sick sinus syndrome the THEOPACE study: a randomized controlled trial.
    Circulation, 1997, Jul-01, Volume: 96, Issue:1

    Topics: Administration, Oral; Aged; Atrial Fibrillation; Cardiac Output, Low; Female; Follow-Up Studies; Hea

1997
A controlled trial of acute and long-term medical therapy in tilt-induced neurally mediated syncope.
    The American journal of cardiology, 1992, Aug-01, Volume: 70, Issue:3

    Topics: Adult; Atenolol; Bandages; Dihydroergotamine; Domperidone; Female; Humans; Isoproterenol; Male; Midd

1992

Other Studies

17 other studies available for theophylline and Syncope

ArticleYear
Theophylline in patients with syncope without prodrome, normal heart, and normal electrocardiogram: a propensity-score matched study verified by implantable cardiac monitor.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2022, 07-21, Volume: 24, Issue:7

    Topics: Atrioventricular Block; Electrocardiography; Heart Arrest; Humans; Propensity Score; Recurrence; Syn

2022
Severe pallid breath-holding spells treated with low-dose theophylline.
    Brain & development, 2021, Volume: 43, Issue:2

    Topics: Apnea; Breath Holding; Dose-Response Relationship, Drug; Heart Arrest; Humans; Infant; Male; Seizure

2021
Efficacy of theophylline in patients with syncope without prodromes with normal heart and normal ECG.
    International journal of cardiology, 2019, 08-15, Volume: 289

    Topics: Adenosine; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Child; Dose-Response Relationship

2019
Asystolic syncope - To pace or not to pace, that is the question.
    International journal of cardiology, 2019, 08-15, Volume: 289

    Topics: Electrocardiography; Heart Arrest; Humans; Syncope; Theophylline

2019
Glycopyrrolate and theophylline for the treatment of severe pallid breath-holding spells.
    Pediatrics, 2013, Volume: 131, Issue:4

    Topics: Apnea; Breath Holding; Female; Glycopyrrolate; Humans; Infant; Muscarinic Antagonists; Phosphodieste

2013
Oral theophylline as temporizing treatment of neck mass induced carotid sinus syncope.
    International journal of cardiology, 2013, Aug-20, Volume: 167, Issue:4

    Topics: Administration, Oral; Head and Neck Neoplasms; Humans; Male; Middle Aged; Syncope; Theophylline; Tre

2013
Efficacy of theophylline in patients affected by low adenosine syncope.
    Heart rhythm, 2016, Volume: 13, Issue:5

    Topics: Adenosine; Adult; Aged; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Stu

2016
ECG of the Month.
    Journal of the American Veterinary Medical Association, 2016, Apr-01, Volume: 248, Issue:7

    Topics: Animals; Dog Diseases; Dogs; Electrocardiography; Female; Pacemaker, Artificial; Sick Sinus Syndrome

2016
Theophylline and syncope.
    International journal of cardiology, 2016, Nov-15, Volume: 223

    Topics: Adult; Atrioventricular Block; Bradycardia; Electrocardiography; Heart Rate; Humans; Male; Purinergi

2016
Mechanism of syncope without prodromes with normal heart and normal electrocardiogram.
    Heart rhythm, 2017, Volume: 14, Issue:2

    Topics: Aged; Atrioventricular Block; Cardiac Pacing, Artificial; Electrocardiography, Ambulatory; Female; H

2017
COUGH SYNCOPE--THE MECHANISM IN TWO CASES.
    Journal of the Irish Medical Association, 1964, Volume: 55

    Topics: Cough; Humans; Syncope; Theophylline; Toxicology

1964
Clinical characteristics of hypervagotonic sinus node dysfunction.
    The Korean journal of internal medicine, 2004, Volume: 19, Issue:3

    Topics: Dizziness; Dyspnea; Female; Humans; Male; Middle Aged; Muscle Weakness; Sick Sinus Syndrome; Syncope

2004
Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia or asystole.
    The New England journal of medicine, 1993, Apr-15, Volume: 328, Issue:15

    Topics: Adolescent; Adult; Aged; Bradycardia; Cardiac Pacing, Artificial; Disopyramide; Female; Follow-Up St

1993
[Pre-syncope and syncope at the operating table--diagnostic and therapeutic possibilities].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1996, Volume: 67, Issue:3

    Topics: Adult; Diagnosis, Differential; General Surgery; Humans; Male; Occupational Diseases; Syncope; Theop

1996
The use of methylphenidate in the treatment of refractory neurocardiogenic syncope.
    Pacing and clinical electrophysiology : PACE, 1996, Volume: 19, Issue:5

    Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Bradycardia; Central Nervous S

1996
Excessive myocardial contraction in vasovagal syncope demonstrated by echocardiography during head-up tilt test.
    Clinical cardiology, 1996, Volume: 19, Issue:2

    Topics: Adrenergic beta-Agonists; Adult; Aged; Analysis of Variance; Echocardiography; Female; Humans; Isopr

1996
The autonomic and hemodynamic effects of oral theophylline in patients with vasodepressor syncope.
    Archives of internal medicine, 1991, Volume: 151, Issue:12

    Topics: Administration, Oral; Adult; Autonomic Nervous System; Bradycardia; Female; Heart; Heart Rate; Human

1991