theophylline has been researched along with Sensitivity and Specificity in 96 studies
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with chronic asthma are often treated with sustained-release theophylline preparations." | 9.08 | [Usefulness of "Biotrack Theophylline kit" for measuring serum theophylline concentration in patients with chronic asthma]. ( Iwata, T, 1996) |
| "Theophylline has also been used in the treatment of patients with asthma, although there is a perception that this drug does not offer the patient any advantages over conventional therapeutic strategies." | 6.42 | Theophylline and PDE4 inhibitors in asthma. ( Spina, D, 2003) |
| "Patients with chronic asthma are often treated with sustained-release theophylline preparations." | 5.08 | [Usefulness of "Biotrack Theophylline kit" for measuring serum theophylline concentration in patients with chronic asthma]. ( Iwata, T, 1996) |
| "The nonspecific phosphodiesterase inhibitor theophylline, widely used in asthma therapy, may cause a decrease in inflammatory responses of airways." | 5.08 | Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro. ( Berends, C; de Monchy, JG; Dijkhuizen, B; Kauffman, HF; Spoelstra, FM, 1998) |
| " We tested the hypothesis that adenosine, prostaglandins, and NO act in synergy to regulate skeletal muscle hyperemia by determining the following: (1) the effect of adenosine receptor blockade on skeletal muscle exercise hyperemia with and without simultaneous inhibition of prostaglandins (indomethacin; 0." | 3.75 | Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation. ( Hellsten, Y; Mortensen, SP; Nyberg, M; Saltin, B; Thaning, P, 2009) |
| "Caffeine has been extensively used as a probe to measure CYP1A2 activity in humans with caffeine clearance or the paraxanthine (major metabolite of caffeine) to caffeine concentration ratio being regarded as the preferred metric." | 2.75 | Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma. ( Gross, AS; McLachlan, AJ; Perera, V, 2010) |
| "Theophylline was well tolerated." | 2.70 | Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. ( Barnes, PJ; Culpitt, SV; de Matos, C; Donnelly, LE; Rogers, DF; Russell, RE, 2002) |
| "Theophylline has also been used in the treatment of patients with asthma, although there is a perception that this drug does not offer the patient any advantages over conventional therapeutic strategies." | 2.42 | Theophylline and PDE4 inhibitors in asthma. ( Spina, D, 2003) |
| " This method can be applied to the pharmacokinetic study of norfloxacin and enoxacin after repeated administration to assess changes in CYP1A2 activity in healthy subjects." | 1.37 | A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition. ( Homma, M; Kobayashi, D; Kobayashi, T; Kohda, Y; Momo, K, 2011) |
| " The developed assay method was applied to a pharmacokinetic study in human volunteers following oral administration of DFL tablet." | 1.35 | Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of doxofylline in human serum: application to a clinical pharmacokinetic study. ( Mullangi, R; Narasu, ML; Shankar, BP; Sreenivas, N, 2008) |
| "Aminophylline was administered intravenously in 13 infants with apnoea, in a loading dose of 5 mg/kg and maintenance dose of 3 mg/kg, every 8 h." | 1.34 | Reliability of salivary theophylline in monitoring the treatment for apnoea of prematurity. ( Chereches-Panta, P; Culea, M; Nanulescu, MV; Palibroda, N, 2007) |
| "Caffeine was determined in ground and instant coffee with precision and accuracy that meet Brazilian norms about such products." | 1.34 | Determination of caffeine in coffee products by dynamic complexation with 3,4-dimethoxycinnamate and separation by CZE. ( do Lago, CL; Nogueira, T, 2007) |
| "Theophylline (Th) has been selectively conjugated to the four amino groups of melittin (Mel) by solid phase peptide synthesis." | 1.31 | Selectively conjugated melittins for liposome time-resolved fluoroimmunoassay of theophylline in serum. ( Bacigalupo, MA; Ius, A; Longhi, R; Meroni, G, 2000) |
| "A capillary electrophoresis method was developed to separate and quantitate ephedrine (ED), theophylline (TP) and phenobarbital (PB) in a tablet dosage form." | 1.30 | Determination of ephedrine, theophylline and phenobarbital in a tablet dosage form by capillary electrophoresis. ( Haque, A; Stewart, JT; Xu, X, 1999) |
| "Statistical principles for analytical goal-setting were applied to two medical applications of drug-monitoring data: (a) individualizing dosage requirements by reference to a population-based therapeutic range or to a patient-specific decision value determined by Bayesian decision analysis, and (b) prospective dosing by using pharmaco-kinetic principles." | 1.28 | Analytical goals for determinations of theophylline concentration in serum. ( Jenny, RW, 1991) |
| "Theophylline was completely separated from paraxanthine, a major metabolite of caffeine which has been known to interfere with most isocratic reversed-phase HPLC methods, with a mixture of acetonitrile/tetrahydrofuran/acetate buffer (10 mM, pH 5." | 1.28 | Separation and determination of theophylline from paraxanthine in human serum by reversed-phase high-performance liquid chromatography. ( Chikuma, M; Kawai, M; Kawakatsu, K; Nishimura, K, 1989) |
| "gentamicin therapy were randomly selected and monitored for possible ADRs." | 1.27 | Sensitivity and specificity of three methods of detecting adverse drug reactions. ( Berry, LL; Fudge, KA; Segal, R; Sherrin, TP, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.08) | 18.7374 |
| 1990's | 35 (36.46) | 18.2507 |
| 2000's | 39 (40.63) | 29.6817 |
| 2010's | 19 (19.79) | 24.3611 |
| 2020's | 1 (1.04) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Mendes, VM | 1 |
| Coelho, M | 1 |
| Tomé, AR | 1 |
| Cunha, RA | 1 |
| Manadas, B | 1 |
| Ahmad, R | 1 |
| Ahmad, N | 1 |
| Al-Anaki, WS | 1 |
| Ismail, FA | 1 |
| Al-Jishi, F | 1 |
| Ma, X | 1 |
| Guo, Z | 1 |
| Mao, Z | 1 |
| Tang, Y | 1 |
| Miao, P | 1 |
| Lau, PS | 2 |
| Lai, CK | 1 |
| Li, Y | 3 |
| Peris-Vicente, J | 1 |
| Rambla-Alegre, M | 1 |
| Durgavanshi, A | 1 |
| Bose, D | 1 |
| Esteve-Romero, J | 2 |
| Marco-Peiró, S | 1 |
| Manthorpe, DP | 1 |
| Lockley, WJ | 1 |
| Park, KS | 1 |
| Oh, SS | 1 |
| Soh, HT | 1 |
| Park, HG | 1 |
| Jiang, H | 2 |
| Ling, K | 2 |
| Tao, X | 2 |
| Zhang, Q | 1 |
| Ozturk, SA | 1 |
| Ceylan, C | 1 |
| Serel, TA | 1 |
| Doluoglu, OG | 1 |
| Soyupek, AS | 1 |
| Guzel, A | 1 |
| Özorak, A | 1 |
| Uz, E | 1 |
| Savas, HB | 1 |
| Baspinar, S | 1 |
| Jordan, NY | 1 |
| Mimpen, JY | 1 |
| van den Bogaard, WJ | 1 |
| Flesch, FM | 1 |
| van de Meent, MH | 1 |
| Torano, JS | 1 |
| De Kesel, PM | 1 |
| Lambert, WE | 1 |
| Stove, CP | 1 |
| Qiu, C | 1 |
| Li, FR | 1 |
| Ogawa, A | 1 |
| Maeda, M | 1 |
| Tachi, T | 1 |
| Kaji, N | 1 |
| Tokeshi, M | 1 |
| Baba, Y | 1 |
| Xie, S | 1 |
| Walton, SP | 1 |
| Mortensen, SP | 1 |
| Nyberg, M | 1 |
| Thaning, P | 1 |
| Saltin, B | 1 |
| Hellsten, Y | 1 |
| Chen, ML | 1 |
| Zheng, MM | 1 |
| Feng, YQ | 1 |
| Kobayashi, T | 1 |
| Homma, M | 1 |
| Momo, K | 1 |
| Kobayashi, D | 1 |
| Kohda, Y | 1 |
| Coombes, BK | 1 |
| Perera, V | 1 |
| Gross, AS | 1 |
| McLachlan, AJ | 1 |
| Lam, BJ | 1 |
| Joyce, GF | 1 |
| Pinhancos, R | 1 |
| Maass, S | 1 |
| Ramanathan, DM | 1 |
| Chae, JW | 1 |
| Kim, DH | 1 |
| Lee, BY | 1 |
| Kim, Ej | 1 |
| Kwon, KI | 1 |
| Barlag, RE | 1 |
| Halsall, HB | 2 |
| Heineman, WR | 2 |
| Kim, HK | 1 |
| Song, KS | 1 |
| Lee, ES | 1 |
| Lee, YJ | 1 |
| Park, YS | 1 |
| Lee, KR | 1 |
| Lee, SN | 1 |
| Iturriaga, H | 1 |
| Coello, J | 1 |
| Maspoch, S | 1 |
| Porcel, M | 1 |
| Kress, M | 2 |
| Meissner, D | 2 |
| Kaiser, P | 2 |
| Hanke, R | 2 |
| Wood, WG | 2 |
| Sekella, PT | 1 |
| Rueda, D | 1 |
| Walter, NG | 1 |
| Spina, D | 1 |
| El-Gindy, A | 1 |
| Emara, S | 2 |
| Hadad, GM | 1 |
| Fischer, R | 1 |
| Vollmar, C | 1 |
| Thiere, M | 1 |
| Born, C | 1 |
| Leitl, M | 1 |
| Pfluger, T | 1 |
| Huber, RM | 1 |
| Christenson, A | 1 |
| Dock, E | 1 |
| Gorton, L | 2 |
| Ruzgas, T | 1 |
| Codipilly, CN | 1 |
| Wapnir, RA | 1 |
| Martinavarro-Domínguez, A | 1 |
| Boseb, D | 1 |
| Durgbanshi, A | 1 |
| Gil-Agustí, M | 1 |
| Capella-Peiró, ME | 1 |
| Broch, SC | 1 |
| Zhang, QL | 1 |
| Lian, HZ | 1 |
| Wang, WH | 1 |
| Chen, HY | 1 |
| Zhou, MX | 1 |
| Guan, CY | 1 |
| Chen, G | 1 |
| Xie, XY | 1 |
| Wu, SH | 1 |
| Saka, K | 1 |
| Uemura, K | 1 |
| Shintani-Ishida, K | 1 |
| Yoshida, K | 1 |
| Ferapontova, EE | 2 |
| Shipovskov, S | 1 |
| Begas, E | 1 |
| Kouvaras, E | 1 |
| Tsakalof, A | 1 |
| Papakosta, S | 1 |
| Asprodini, EK | 1 |
| Chereches-Panta, P | 1 |
| Nanulescu, MV | 1 |
| Culea, M | 1 |
| Palibroda, N | 1 |
| Nogueira, T | 1 |
| do Lago, CL | 1 |
| Beaudry, F | 1 |
| Vachon, P | 1 |
| Pei, R | 1 |
| Stojanovic, MN | 1 |
| Sreenivas, N | 1 |
| Narasu, ML | 1 |
| Shankar, BP | 1 |
| Mullangi, R | 1 |
| Olsen, EM | 1 |
| Gothelf, KV | 1 |
| Boylan, SM | 1 |
| Cade, JE | 1 |
| Kirk, SF | 1 |
| Greenwood, DC | 1 |
| White, KL | 1 |
| Shires, S | 1 |
| Simpson, NA | 1 |
| Wild, CP | 1 |
| Hay, AW | 1 |
| Lapenna, D | 1 |
| De Gioia, S | 1 |
| Mezzetti, A | 1 |
| Ciofani, G | 1 |
| Festi, D | 1 |
| Cuccurullo, F | 1 |
| Hieda, Y | 1 |
| Kashimura, S | 1 |
| Hara, K | 1 |
| Kageura, M | 1 |
| Thienpont, LM | 1 |
| Van Nieuwenhove, B | 1 |
| Stöckl, D | 1 |
| De Leenheer, AP | 1 |
| Yao, H | 1 |
| Jenkins, SH | 1 |
| Fozard, JR | 1 |
| Carruthers, AM | 1 |
| Jenny, RW | 2 |
| Ducharme, FM | 1 |
| Kramer, MS | 1 |
| Rubino, A | 1 |
| Ralevic, V | 1 |
| Burnstock, G | 1 |
| Oh, C | 1 |
| Kim, J | 1 |
| Kearns, B | 1 |
| Cheng, A | 1 |
| Dobashi, T | 1 |
| Davis, JD | 1 |
| Aarons, L | 1 |
| Houston, JB | 1 |
| Filinger, EJ | 1 |
| Adler-Graschinsky, E | 1 |
| Jubran, A | 1 |
| Gross, N | 1 |
| Ramsdell, J | 1 |
| Simonian, R | 1 |
| Schuttenhelm, K | 1 |
| Sax, M | 1 |
| Kaniecki, DJ | 1 |
| Arnold, RJ | 1 |
| Sonnenberg, FA | 1 |
| Schreiber-Deturmeny, E | 1 |
| Bruguerolle, B | 1 |
| Aboleneen, H | 1 |
| Simpson, J | 1 |
| Backes, D | 1 |
| Teune, TM | 1 |
| Timmers-Reker, AJ | 1 |
| Bouquet, J | 1 |
| Bijman, J | 1 |
| De Jonge, HR | 1 |
| Sinaasappel, M | 1 |
| Lutter, N | 1 |
| Engl, HG | 1 |
| Fischer, F | 1 |
| Bauer, RD | 1 |
| Iwata, T | 1 |
| Delbeke, FT | 1 |
| De Backer, P | 1 |
| Dimitriou, G | 1 |
| Greenough, A | 1 |
| Laubscher, B | 1 |
| Zimmermann, GR | 1 |
| Jenison, RD | 1 |
| Wick, CL | 1 |
| Simorre, JP | 1 |
| Pardi, A | 1 |
| Knebel, NG | 1 |
| Winkler, M | 1 |
| Chiem, NH | 1 |
| Harrison, DJ | 1 |
| Ayrton, J | 1 |
| Dear, GJ | 1 |
| Leavens, WJ | 1 |
| Mallett, DN | 1 |
| Plumb, RS | 1 |
| Spoelstra, FM | 1 |
| Berends, C | 1 |
| Dijkhuizen, B | 1 |
| de Monchy, JG | 1 |
| Kauffman, HF | 1 |
| Agasøster, T | 1 |
| Campisi, B | 1 |
| Chicco, D | 1 |
| Vojnovic, D | 1 |
| Phan-Tan-Luu, R | 1 |
| Kamberi, M | 1 |
| Hajime, N | 1 |
| Kamberi, P | 1 |
| Uemura, N | 1 |
| Nakamura, K | 1 |
| Nakano, S | 1 |
| Koch, JP | 1 |
| ten Tusscher, GW | 1 |
| Koppe, JG | 1 |
| Guchelaar, HJ | 1 |
| Scott, RJ | 1 |
| Palmer, J | 1 |
| Lewis, IA | 1 |
| Pleasance, S | 1 |
| Schult, K | 1 |
| Katerkamp, A | 1 |
| Trau, D | 1 |
| Grawe, F | 1 |
| Cammann, K | 1 |
| Meusel, M | 1 |
| Haque, A | 1 |
| Xu, X | 1 |
| Stewart, JT | 1 |
| Kanazawa, H | 2 |
| Atsumi, R | 1 |
| Matsushima, Y | 2 |
| Kizu, J | 2 |
| Stredansky, M | 1 |
| Pizzariello, A | 1 |
| Miertus, S | 1 |
| Svorc, J | 1 |
| Ius, A | 1 |
| Bacigalupo, MA | 1 |
| Longhi, R | 1 |
| Meroni, G | 1 |
| Henze, MK | 1 |
| Opfermann, G | 1 |
| Spahn-Langguth, H | 1 |
| Schänzer, W | 1 |
| Blanco, M | 1 |
| Valverde, I | 1 |
| Bispo, MS | 1 |
| Veloso, MC | 1 |
| Pinheiro, HL | 1 |
| De Oliveira, RF | 1 |
| Reis, JO | 1 |
| De Andrade, JB | 1 |
| Rabe, KF | 1 |
| Culpitt, SV | 1 |
| de Matos, C | 1 |
| Russell, RE | 1 |
| Donnelly, LE | 1 |
| Rogers, DF | 1 |
| Barnes, PJ | 1 |
| Danilova, NP | 1 |
| Beckman, NI | 1 |
| Yazynin, SA | 1 |
| Vasilov, RG | 1 |
| Jandreski, MA | 1 |
| Shah, JC | 1 |
| Garbincius, J | 1 |
| Bermes, EW | 1 |
| Amodio, P | 1 |
| Lauro, S | 1 |
| Rondana, M | 1 |
| Crema, G | 1 |
| Merkel, C | 1 |
| Gatta, A | 1 |
| Ruol, A | 1 |
| Kawakatsu, K | 1 |
| Nishimura, K | 1 |
| Kawai, M | 1 |
| Chikuma, M | 1 |
| Berry, LL | 1 |
| Segal, R | 1 |
| Sherrin, TP | 1 |
| Fudge, KA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784] | Phase 1 | 18 participants (Anticipated) | Interventional | 2024-06-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for theophylline and Sensitivity and Specificity
| Article | Year |
|---|---|
Theophylline and PDE4 inhibitors in asthma.
Topics: Administration, Oral; Asthma; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; | 2003 |
[Simultaneous determination of theophylline and its metabolites by HPLC].
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Sensitivity and Specificity; Theophylline; X | 2000 |
5 trials available for theophylline and Sensitivity and Specificity
| Article | Year |
|---|---|
Caffeine and paraxanthine HPLC assay for CYP1A2 phenotype assessment using saliva and plasma.
Topics: Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Drug Stab | 2010 |
No evidence of cerebral oedema in severe acute mountain sickness.
Topics: Acetazolamide; Altitude Sickness; Brain; Brain Edema; Cross-Over Studies; Double-Blind Method; Human | 2004 |
[Usefulness of "Biotrack Theophylline kit" for measuring serum theophylline concentration in patients with chronic asthma].
Topics: Age Factors; Asthma; Bronchodilator Agents; Child; Child, Preschool; Delayed-Action Preparations; Hu | 1996 |
Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Blood Cell Count; Cells, Cultured; Down-Regulat | 1998 |
Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease.
Topics: Aged; Chemotaxis, Leukocyte; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; | 2002 |
89 other studies available for theophylline and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve.
Topics: Caffeine; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; T | 2019 |
Solvent and temperature effect of accelerated solvent extraction (ASE) coupled with ultra-high-pressure liquid chromatography (UHPLC-PDA) for the determination of methyl xanthines in commercial tea and coffee.
Topics: Caffeine; Chromatography, High Pressure Liquid; Coffee; Sensitivity and Specificity; Solvents; Tea; | 2020 |
Colorimetric theophylline aggregation assay using an RNA aptamer and non-crosslinking gold nanoparticles.
Topics: Aptamers, Nucleotide; Biosensing Techniques; Color; Colorimetry; Gold; Humans; Metal Nanoparticles; | 2017 |
Quality control certification of RNA aptamer-based detection.
Topics: Aptamers, Nucleotide; Base Sequence; Binding Sites; Biosensing Techniques; Humans; Quality Control; | 2013 |
Xanthine derivatives quantification in serum by capillary zone electrophoresis.
Topics: Buffers; Caffeine; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Limit of Detection; Repro | 2014 |
Digitally enhanced thin layer chromatography: further development and some applications in isotopic chemistry.
Topics: Anthraquinones; Caffeine; Carotenoids; Chromatography, Thin Layer; Image Processing, Computer-Assist | 2013 |
Target-controlled formation of silver nanoclusters in abasic site-incorporated duplex DNA for label-free fluorescence detection of theophylline.
Topics: Biosensing Techniques; DNA; Equipment Design; Equipment Failure Analysis; Metal Nanoparticles; Nanoc | 2014 |
Theophylline detection in serum using a self-assembling RNA aptamer-based gold nanoparticle sensor.
Topics: Aptamers, Nucleotide; Biosensing Techniques; Bronchodilator Agents; Crystallization; Equipment Desig | 2015 |
Protective effect of theophylline on renal functions in experimental pneumoperitoneum model.
Topics: Acute Kidney Injury; Animals; Biomarkers; Biopsy, Needle; Creatine; Cystatin C; Disease Models, Anim | 2015 |
Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Linear Models; Phen | 2015 |
Does volumetric absorptive microsampling eliminate the hematocrit bias for caffeine and paraxanthine in dried blood samples? A comparative study.
Topics: Blood Specimen Collection; Caffeine; Chromatography, Gas; Dried Blood Spot Testing; Healthy Voluntee | 2015 |
A self-assembling RNA aptamer-based graphene oxide sensor for the turn-on detection of theophylline in serum.
Topics: Aptamers, Nucleotide; Biosensing Techniques; Blood Chemical Analysis; Bronchodilator Agents; Equipme | 2016 |
Simple and rapid colorimetric detection of cofactors of aptazymes using noncrosslinking gold nanoparticle aggregation.
Topics: Biosensing Techniques; Caffeine; Chemistry, Pharmaceutical; Colorimetry; Cross-Linking Reagents; DNA | 2008 |
Microchip-based homogeneous immunoassay using a cloned enzyme donor.
Topics: Bacteria; beta-Galactosidase; Fluorescence; Humans; Immunoenzyme Techniques; Microchip Analytical Pr | 2009 |
Application and analysis of structure-switching aptamers for small molecule quantification.
Topics: Aptamers, Nucleotide; Biosensing Techniques; Caffeine; Nucleic Acid Conformation; Polymerase Chain R | 2009 |
Adenosine contributes to blood flow regulation in the exercising human leg by increasing prostaglandin and nitric oxide formation.
Topics: Adenosine; Adult; Analysis of Variance; Cohort Studies; Exercise; Humans; Hyperemia; Indomethacin; L | 2009 |
Preparation of organic-inorganic hybrid silica monolith with octyl and sulfonic acid groups for capillary electrochromatograhpy and application in determination of theophylline and caffeine in beverage.
Topics: Acetonitriles; Beverages; Caffeine; Capillary Electrochromatography; Electroosmosis; Food Analysis; | 2010 |
A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-4 | 2011 |
A general approach to the construction of structure-switching reporters from RNA aptamers.
Topics: Aptamers, Nucleotide; Base Sequence; Biosensing Techniques; Fluorescence; Fluorescent Dyes; Nucleic | 2010 |
An isothermal system that couples ligand-dependent catalysis to ligand-independent exponential amplification.
Topics: Aptamers, Nucleotide; Bacteriophages; Base Sequence; Biosensing Techniques; Catalysis; DNA-Directed | 2011 |
High-resolution mass spectrometry method for the detection, characterization and quantitation of pharmaceuticals in water.
Topics: Caffeine; Chromatography, Liquid; Drinking Water; Drug Stability; Linear Models; Pharmaceutical Prep | 2011 |
Development and validation of a sensitive LC-MS/MS method for the simultaneous quantitation of theophylline and its metabolites in rat plasma.
Topics: Animals; Chromatography, Liquid; Drug Stability; Least-Squares Analysis; Rats; Reproducibility of Re | 2012 |
Amperometric homogeneous competitive immunoassay in a perfluorocarbon emulsion oxygen therapeutic (PEOT).
Topics: Anticonvulsants; Blood Substitutes; Bronchodilator Agents; Electrochemical Techniques; Enzyme Multip | 2013 |
Optimized flow cytometric assay for the measurement of platelet microparticles in plasma: pre-analytic and analytic considerations.
Topics: Adenosine; Adult; Anticoagulants; beta-Thromboglobulin; Biomarkers; Blood Platelets; Blood Preservat | 2002 |
Kinetic-spectrophotometric determination of theophylline, dyphylline, and proxyphylline by use of partial least-squares regression.
Topics: Aminophylline; Bronchodilator Agents; Chromatography, High Pressure Liquid; Dyphylline; Hydrogen-Ion | 2002 |
The measurement of theophylline in human serum or plasma using gas chromatography and isotope dilution-mass spectrometry (GC-IDMS) taking other substituted xanthines into consideration.
Topics: Acetamides; Chromatography, High Pressure Liquid; Fluoroacetates; Gas Chromatography-Mass Spectromet | 2002 |
Determination of theophylline by HPLC and GC-IDMS, the effect of chemically similar xanthine derivatives on the specificity of the method and the possibility of paracetamol as interfering substance.
Topics: Acetaminophen; Calibration; Chemical Precipitation; Chromatography, High Pressure Liquid; Gas Chroma | 2002 |
A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage.
Topics: Base Pairing; Base Sequence; Binding Sites; Biosensing Techniques; Caffeine; Fluorescence Resonance | 2002 |
Determination of two ternary mixtures containing phenobarbitone by second derivative of the ratio spectrum-zero-crossing and HPLC methods.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Mephobarbital; Papaverine; Phenobarbital; Phe | 2003 |
Direct heterogeneous electron transfer of theophylline oxidase.
Topics: Biosensing Techniques; Coated Materials, Biocompatible; Electrochemistry; Electron Transport; Oxidor | 2004 |
Simultaneous determination of caffeine, theophylline and theobromine in human plasma by on-line solid-phase extraction coupled to reversed-phase chromatography.
Topics: Buffers; Caffeine; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Methano | 2004 |
Proabsorptive action of gum arabic in isotonic solutions orally administered to rats. II. Effects on solutes under normal and secretory conditions.
Topics: Acetaminophen; Administration, Oral; Animals; Area Under Curve; Biological Availability; Disease Mod | 2004 |
Monitoring bronchodilators with direct injection.
Topics: Bronchodilator Agents; Caffeine; Calibration; Chromatography, Liquid; Humans; Reproducibility of Res | 2005 |
Separation of caffeine and theophylline in poly(dimethylsiloxane) microchannel electrophoresis with electrochemical detection.
Topics: Animals; Caffeine; Dimethylpolysiloxanes; Electrochemistry; Electrophoresis, Capillary; Hydrogen-Ion | 2005 |
Determination of theophylline concentration in serum by chemiluminescent immunoassay.
Topics: Blood Chemical Analysis; Female; Fluorescence Polarization Immunoassay; Humans; Luminescent Measurem | 2005 |
Acetic acid improves the sensitivity of theophylline analysis by gas chromatography-mass spectrometry.
Topics: Acetic Acid; Bronchodilator Agents; Calibration; Gas Chromatography-Mass Spectrometry; Sensitivity a | 2007 |
Bioelectrocatalytic detection of theophylline at theophylline oxidase electrodes.
Topics: Biosensing Techniques; Catalysis; Coated Materials, Biocompatible; Electrochemistry; Enzymes, Immobi | 2007 |
In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High | 2007 |
Reliability of salivary theophylline in monitoring the treatment for apnoea of prematurity.
Topics: Aminophylline; Apnea; Bronchodilator Agents; Drug Monitoring; Female; Humans; Infant; Infant, Newbor | 2007 |
Determination of caffeine in coffee products by dynamic complexation with 3,4-dimethoxycinnamate and separation by CZE.
Topics: Anions; Beverages; Binding Sites; Caffeine; Chlorogenic Acid; Cinnamates; Coffee; Electric Conductiv | 2007 |
Determination of glucosamine in horse plasma by liquid chromatography tandem mass spectrometry.
Topics: Acetonitriles; Animals; Carbon Isotopes; Chromatography, High Pressure Liquid; Formates; Glucosamine | 2008 |
Study of thiazole orange in aptamer-based dye-displacement assays.
Topics: Adenosine Triphosphate; Aptamers, Nucleotide; Benzothiazoles; Cyclic AMP; Fluorescent Dyes; Guanosin | 2008 |
Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of doxofylline in human serum: application to a clinical pharmacokinetic study.
Topics: Bronchodilator Agents; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducib | 2008 |
An RNA aptamer-based electrochemical biosensor for detection of theophylline in serum.
Topics: Aptamers, Nucleotide; Base Sequence; Biosensing Techniques; Electrochemistry; Electrodes; Gold; Huma | 2008 |
Assessing caffeine exposure in pregnant women.
Topics: Adult; Biomarkers; Caffeine; Diet Records; Feeding Behavior; Female; Humans; Pregnancy; Pregnancy Ou | 2008 |
Aminophylline: could it act as an antioxidant in vivo?
Topics: Aminophylline; Antioxidants; Deoxyribose; Epithelium; Free Radical Scavengers; Humans; Hydroxyl Radi | 1995 |
Highly sensitive and rapid determination of theophylline, theobromine and caffeine in human plasma and urine by gradient capillary high-performance liquid chromatography-frit-fast atom bombardment mass spectrometry.
Topics: Caffeine; Capillary Action; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results | 1995 |
Candidate reference method for determining serum theophylline applied to target-setting in external quality assessment and routine method evaluation.
Topics: Evaluation Studies as Topic; Gas Chromatography-Mass Spectrometry; Humans; Indicator Dilution Techni | 1994 |
Electrochemical dehydrogenase-based homogeneous assays in whole blood.
Topics: 2,6-Dichloroindophenol; Blood Glucose; Electrochemistry; Electrodes; Erythrocytes; Hematocrit; Hexok | 1995 |
The cardiovascular effects of selective adenosine A1 and A2 receptor agonists in the pithed rat: no role for glibenclamide-sensitive potassium channels.
Topics: Adenosine; Adrenergic alpha-Agonists; Angiotensin II; Animals; Benzopyrans; Blood Pressure; Cardiova | 1993 |
Process capability and stability of analytical systems assessed from proficiency testing data.
Topics: Chemistry, Clinical; Humans; Laboratories; Quality Control; Sensitivity and Specificity; Theophyllin | 1994 |
Relapse following emergency treatment for acute asthma: can it be predicted or prevented?
Topics: Acute Disease; Adolescent; Asthma; Canada; Child; Child, Preschool; Emergencies; Emergency Service, | 1993 |
The P1-purinoceptors that mediate the prejunctional inhibitory effect of adenosine on capsaicin-sensitive nonadrenergic noncholinergic neurotransmission in the rat mesenteric arterial bed are of the A1 subtype.
Topics: Adenosine; Adrenergic Fibers; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cholinergic Fiber | 1993 |
A rate turbidimetric immunoassay for theophylline using biotin-avidin system.
Topics: Avidin; Biotin; Evaluation Studies as Topic; Fluorescence Polarization Immunoassay; Humans; Immunoas | 1993 |
Simultaneous assay of fluoroquinolones and theophylline in plasma by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Ciprofloxacin; Enoxacin; Male; Norfloxacin; Rats; Rat | 1993 |
Pertussis toxin sensitive effects of dipyridamole on rat atrial rate.
Topics: Adenosine; Animals; Atrial Function; Depression, Chemical; Dipyridamole; Drug Interactions; Female; | 1993 |
Comparative cost-effectiveness analysis of theophylline and ipratropium bromide in chronic obstructive pulmonary disease. A three-center study.
Topics: Aged; Analysis of Variance; California; Chi-Square Distribution; Cost of Illness; Cost-Benefit Analy | 1993 |
Simultaneous high-performance liquid chromatographic determination of caffeine and theophylline for routine drug monitoring in human plasma.
Topics: Caffeine; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducibility of Resu | 1996 |
Determination of methotrexate in serum by high-performance liquid chromatography.
Topics: Acetonitriles; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Humans; Methot | 1996 |
In vivo measurement of chloride and water secretion in the jejunum of cystic fibrosis patients.
Topics: Adolescent; Adult; Bicarbonates; Body Water; Catheterization; Chlorides; Cystic Fibrosis; Electrophy | 1996 |
Noninvasive continuous blood pressure control by pulse wave velocity.
Topics: Adult; Aged; Blood Flow Velocity; Blood Pressure Monitors; Catheters, Indwelling; Female; Humans; Hy | 1996 |
Threshold level for theophylline in doping analysis.
Topics: Caffeine; Chromatography, High Pressure Liquid; Doping in Sports; Humans; Male; Reproducibility of R | 1996 |
Lung volume measurements immediately after extubation by prediction of "extubation failure" in premature infants.
Topics: Female; Functional Residual Capacity; Humans; Infant, Newborn; Infant, Premature; Intubation, Intrat | 1996 |
Interlocking structural motifs mediate molecular discrimination by a theophylline-binding RNA.
Topics: Bronchodilator Agents; Caffeine; Cytosine; Magnetic Resonance Spectroscopy; Models, Molecular; Molec | 1997 |
Rapid and automated determination of the beta2-agonist reproterol in human plasma by atmospheric pressure chemical ionisation high-performance liquid chromatography-tandem mass spectrometry.
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Chromatography, High Pre | 1997 |
Microchip systems for immunoassay: an integrated immunoreactor with electrophoretic separation for serum theophylline determination.
Topics: Automation; Electronics; Electrophoresis; Equipment Design; Fluorescent Antibody Technique; Humans; | 1998 |
Use of generic fast gradient liquid chromatography-tandem mass spectroscopy in quantitative bioanalysis.
Topics: Acetanilides; Animals; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cresols; Keton | 1998 |
Aqueous two-phase partitioning sample preparation prior to liquid chromatography of hydrophilic drugs in blood.
Topics: Acetaminophen; Animals; Blood Proteins; Buffers; Cattle; Chemical Precipitation; Chromatography, Hig | 1998 |
Experimental design for a pharmaceutical formulation: optimisation and robustness.
Topics: Chemistry, Pharmaceutical; Drug Compounding; Models, Theoretical; Reproducibility of Results; Resear | 1998 |
Simultaneous determination of grepafloxacin, ciprofloxacin, and theophylline in human plasma and urine by HPLC.
Topics: Anti-Infective Agents; Chromatography, High Pressure Liquid; Ciprofloxacin; Drug Interactions; Drug | 1999 |
Validation of a high-performance liquid chromatography assay for quantification of caffeine and paraxanthine in human serum in the context of CYP1A2 phenotyping.
Topics: Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Phenotype; Reproduc | 1999 |
Determination of a 'GW cocktail' of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry.
Topics: Automation; Caffeine; Chlorzoxazone; Chromatography, Gas; Chromatography, High Pressure Liquid; Cyto | 1999 |
Disposable optical sensor chip for medical diagnostics: new ways in bioanalysis.
Topics: Biosensing Techniques; Chorionic Gonadotropin; Diagnostic Techniques and Procedures; Female; Humans; | 1999 |
Determination of ephedrine, theophylline and phenobarbital in a tablet dosage form by capillary electrophoresis.
Topics: Calibration; Drug Combinations; Electrophoresis, Capillary; Ephedrine; Hydrogen-Ion Concentration; P | 1999 |
Determination of theophylline and its metabolites in biological samples by liquid chromatography-mass spectrometry.
Topics: Calibration; Chromatography, Liquid; Mass Spectrometry; Reproducibility of Results; Sensitivity and | 2000 |
Selective and sensitive biosensor for theophylline based on xanthine oxidase electrode.
Topics: Biosensing Techniques; Electric Conductivity; Enzymes, Immobilized; Humans; Hydrogen-Ion Concentrati | 2000 |
Selectively conjugated melittins for liposome time-resolved fluoroimmunoassay of theophylline in serum.
Topics: Amino Acid Sequence; Antibodies; Calibration; Dose-Response Relationship, Drug; Europium; Fluorescen | 2000 |
Screening of beta-2 agonists and confirmation of fenoterol, orciprenaline, reproterol and terbutaline with gas chromatography-mass spectrometry as tetrahydroisoquinoline derivatives.
Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Calibration; Drug Combinations; Fe | 2001 |
Application of micellar electrokinetic chromatography to the quality control of a pharmaceutical preparation containing three bronchodilators.
Topics: Aminophylline; Bronchodilator Agents; Chromatography, Micellar Electrokinetic Capillary; Drug Combin | 2002 |
Simultaneous determination of caffeine, theobromine, and theophylline by high-performance liquid chromatography.
Topics: Beverages; Caffeine; Calibration; Chromatography, High Pressure Liquid; Sensitivity and Specificity; | 2002 |
On theophylline, leukocytes, and chicken soup.
Topics: Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; Female; Humans; Male; Neutrophils; Pulmonar | 2002 |
Fast filtration enzyme immunoassay for haptens.
Topics: Animals; Antibodies, Monoclonal; Digoxin; Filtration; Haptens; Horseradish Peroxidase; Humans; Immun | 1992 |
Clinical evaluation of five therapeutic drugs using dry film multilayer technology on the OPUS immunoassay system.
Topics: Carbamazepine; Evaluation Studies as Topic; Humans; Immunoassay; Pharmaceutical Preparations; Phenob | 1991 |
Theophylline pharmacokinetics and liver function indexes in chronic liver disease.
Topics: Adult; Aged; Female; Hepatitis, Chronic; Humans; Liver; Liver Cirrhosis; Male; Metabolic Clearance R | 1991 |
Analytical goals for determinations of theophylline concentration in serum.
Topics: Humans; Sensitivity and Specificity; Theophylline | 1991 |
Separation and determination of theophylline from paraxanthine in human serum by reversed-phase high-performance liquid chromatography.
Topics: Aged; Aged, 80 and over; Calibration; Chromatography, High Pressure Liquid; Female; Humans; Reproduc | 1989 |
Sensitivity and specificity of three methods of detecting adverse drug reactions.
Topics: Algorithms; Computers; Data Collection; Digoxin; Drug-Related Side Effects and Adverse Reactions; Ge | 1988 |