theophylline has been researched along with Seizures in 213 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures." | 8.85 | Seizures associated with levofloxacin: case presentation and literature review. ( Bellon, A; Chacko, RC; Coverdale, JH; Perez-Garcia, G, 2009) |
| "Theophylline-associated seizures (TAS) are considered a neurologic emergency, as they can sometimes be intractable and difficult to stop with standard treatments such as intravenous administration of diazepam." | 8.84 | First-line therapy for theophylline-associated seizures. ( Yoshikawa, H, 2007) |
| "Oral theophylline augmentation can be considered as an effective treatment option for patients undergoing ECT with inadequate seizures." | 8.12 | Oral theophylline augmentation for patients with missed or inadequate seizures with electroconvulsive therapy. ( Gon, J; Iwamoto, T; Kurata, A; Shimizu, H; Wada, K, 2022) |
| " She had bronchial asthma, was previously diagnosed with cerebral infarction, had experienced two events of convulsive status epilepticus, and was undergoing treatment with theophylline, levetiracetam, and clopidogrel." | 8.02 | [Nonconvulsive Status Epilepticus Associated with Theophylline: A Case Report]. ( Inoue, T; Kurokawa, K; Uemura, J; Yagita, Y; Yamashita, S, 2021) |
| "Theophylline-associated seizures (TAS) often progress to prolonged or treatment-resistant convulsions." | 7.76 | Adenosine A1 receptor blockage mediates theophylline-associated seizures. ( Fukuda, M; Hino, H; Ishii, E; Kuzume, K; Morimoto, T; Suzuki, Y, 2010) |
| "We report a 70-year-old man who developed theophylline-associated seizure with postictal fever and postictal pleocytosis." | 7.76 | [A case of theophylline-associated seizures with postictal fever and postictal pleocytosis]. ( Mouri, W; Yaguchi, H; Yaguchi, M, 2010) |
| "We presume it necessary to pay heed to fever and neurologic predispositions in order to prevent sequelae or death that may occur subsequently to seizures that developed during theophylline administration." | 7.74 | [Clinical review of patients with seizures that developed during theophylline administration--(III) Safety of theophylline examined in patients who had sequelae or died]. ( Kato, T; Nakano, H; Odajima, Y; Okada, K, 2008) |
| "Theophylline-associated seizures (TAS) are considered a neurologic emergency, as they can sometimes be intractable and difficult to stop with standard treatments such as intravenous administration of diazepam." | 7.74 | First-line therapy for theophylline-associated seizures. ( Yoshikawa, H, 2007) |
| "To elucidate the basic mechanism of theophylline-associated seizures (TAS), the clinical symptoms, electroencephalogram (EEG) and neuroradiological imaging of eight pediatric patients were all retrospectively evaluated." | 7.74 | Theophylline-associated seizures and their clinical characterizations. ( Izumi, T; Korematsu, S; Miyahara, H; Nagakura, T; Suenobu, S, 2008) |
| "We report an 81-year-old woman who suffered from theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency." | 7.74 | [Case of an 81-year-old woman with theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency]. ( Inaba, A; Kuwahara, H; Mizusawa, H; Noguchi, Y, 2008) |
| "In the present study, we investigated the effects of micro-injecting 2-chloroadenosine (2-CADO; an adenosine receptor agonist) into the thalamus alone and with theophylline (a nonspecific adenosine receptor antagonist) pretreatment on pentylenetetrazol (PTZ)-induced tonic-clonic seizures in male Wistar albino rats." | 7.73 | Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application. ( Ates, N; Ilbay, G; Sahin, D, 2005) |
| "The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats." | 7.71 | Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. ( Chaudhary, G; Gupta, YK; Srivastava, AK, 2002) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 7.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| "Effects of Saiko-ka-ryukotsu-borei-to (SRBT) on theophylline-induced tachycardia in anesthetized rats and theophylline-induced locomotion and convulsions in mice were examined." | 7.70 | Effects of Saiko-ka-ryukotsu-borei-to, a Japanese Kampo medicine, on tachycardia and central nervous system stimulation induced by theophylline in rats and mice. ( Chisaki, K; Hayashi, H; Komatsu, Y; Sanae, F, 1999) |
| "Isoniazid-induced seizures respond poorly to anticonvulsants but well to pyridoxine (Vitamin B6); theophylline produces difficult-to-treat seizures with substantial morbidity and mortality." | 7.70 | Seizures induced by theophylline and isoniazid in mice. ( Bonner, AB; Peterson, SL; Weir, MR, 1999) |
| "Seizures is a major toxicity of theophylline." | 7.70 | Influence of adenosine agonists and antiepileptic drugs on theophylline-induced seizures in rats. ( Gupta, YK; Malhotra, J, 1998) |
| "In order to study whether a theophylline-related seizure is caused by a decrease in serum vitamin B6, serum pyridoxal (PAL) levels were measured in children with bronchial asthma treated with theophylline." | 7.70 | [Depression of serum pyridoxal levels in theophylline-related seizures]. ( Furukawa, K; Hattori, H; Hayashi, K; Inada, H; Isshiki, G; Kobayashi, N; Matsuoka, O; Seto, T; Tada, H, 2000) |
| "To evaluate the potential anticonvulsant effects of Adenocard in theophylline-induced seizures, we developed a rodent model of theophylline neurotoxicity with resultant convulsions." | 7.69 | Anticonvulsant effects of intracerebroventricular adenocard in theophylline-induced seizures. ( Maher, T; Shannon, M, 1995) |
| "One of the most dangerous aspects of theophylline toxicity is seizures." | 7.69 | Adenosine receptors are not involved in theophylline-induced seizures. ( Hornfeldt, CS; Larson, AA, 1994) |
| "Two patients developed a disabling amnesic syndrome after seizures associated with oral theophylline treatment." | 7.69 | Amnesic syndrome after theophylline associated seizures: iatrogenic brain injury. ( FitzGerald, MX; Hutchinson, J; Hutchinson, M; O'Riordan, JI, 1994) |
| "Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat." | 7.69 | Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995) |
| " The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats." | 7.69 | Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "Seizures, often with fatal outcome, are a manifestation of pronounced theophylline toxicity." | 7.68 | Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat. ( Gilhar, D; Hoffman, A; Pinto, E, 1993) |
| "The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline." | 7.68 | Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993) |
| "We report 12 adults with seizures associated with serum theophylline levels between 14 and 35 mg/l." | 7.68 | Theophylline-associated seizures with "therapeutic" or low toxic serum concentrations: risk factors for serious outcome in adults. ( Bahls, FH; Bird, TD; Ma, KK, 1991) |
| "The anticonvulsant actions of the adenosine receptor agonists, 1-phenylisopropyladenosine, 2-chloroadenosine and cyclohexyl-adenosine, against DMCM (methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate)-induced seizures in mice were studied with an infusion technique." | 7.68 | Selective protection by adenosine receptor agonists against DMCM-induced seizures. ( Petersen, EN, 1991) |
| "Five patients had apparently drug-induced seizures while simultaneously receiving theophylline and either imipenem (three patients), ciprofloxacin (one patient), or ciprofloxacin and metronidazole (one patient)." | 7.68 | Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. ( Allen, N; Semel, JD, 1991) |
| " Its protective efficacy against theophylline-induced seizures was determined in this investigation in view of the limited effectiveness of presently available anticonvulsants against this manifestation of serious theophylline intoxication." | 7.68 | Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "Caffeine as well as the antiasthmatic drug theophylline can cause seizures when administered to humans or animals in excessive doses." | 7.68 | Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "Hippocampal and neocortical blood flows and tissue pO2 were investigated by mass spectrometry in unanaesthetized spontaneously breathing rats during kainic acid-induced seizures to determine whether adenosine is involved in the coupling of cerebral blood flow to metabolism during enhanced metabolic demand." | 7.68 | Theophylline reduces cerebral hyperaemia and enhances brain damage induced by seizures. ( Pinard, E; Puiroud, S; Riche, D; Seylaz, J, 1990) |
| "Kainic acid (KA), microinjected unilaterally into the rat prepiriform cortex (PC), produces generalized motor seizures in a dose-dependent manner." | 7.68 | Anticonvulsant effect of N-ethylcarboxamidoadenosine against kainic acid-induced behavioral seizures in the rat prepiriform cortex. ( Franklin, PH; Murray, TF; Zhang, G, 1990) |
| " infusion of theophylline until the onset of maximal seizures had no significant effect on the total dose and the serum and cerebrospinal fluid concentrations of theophylline at the pharmacologic endpoint." | 7.67 | Aspartame and phenylalanine do not enhance theophylline-induced seizures in rats. ( Levy, G; Zhi, JQ, 1989) |
| " The effects of papaverine, an adenosine uptake inhibitor, were tested against theophylline-induced seizures." | 7.67 | Proconvulsant effect of papaverine on theophylline-induced seizures in rats. ( Ramzan, I, 1989) |
| "This investigation was designed to determine the effect of fever on the neurotoxicity of theophylline as reflected by the concentrations of this drug that cause convulsions in experimental animals." | 7.67 | Kinetics of drug action in disease states. XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Yasuhara, M, 1988) |
| "We evaluated the efficacy of pretreatment with phenytoin and phenobarbital to prevent seizures in mice given convulsive doses of theophylline." | 7.67 | Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice. ( Blake, KV; Hendeles, L; Massey, KL; Neims, A; Nickerson, D, 1988) |
| "Generalized seizures may be associated with therapeutic or intentional theophylline overdose." | 7.67 | The effect of serum potassium on theophylline-induced seizures. ( Adler, S; Borok, Z; Fraley, DS; Schneider, SM, 1988) |
| "Seizures, often with fatal outcome, are a manifestation of pronounced theophylline intoxication." | 7.67 | Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Ramzan, IM, 1986) |
| "Theophylline, the widely used antiasthmatic drug, can cause life-threatening, generalized seizures when administered in excessive doses." | 7.67 | Chronic theophylline administration has no apparent effect on theophylline concentrations required to produce seizures in rats. ( Levy, G; Ramzan, IM, 1986) |
| " If no cause is found, the diagnosis of idiopathic infantile apnea is made." | 7.67 | Infantile apnea. ( McCulloch, K; Vidyasagar, D, 1986) |
| "To determine the effect of phenobarbital sodium therapy and subependymal intraventricular hemorrhage (SEp-IVH) on the theophylline requirement of premature infants suffering with apnea and seizure activity, we compared three groups of patients as follows: group 1, those with apnea of prematurity (ten patients); group 2, those with apnea and SEp-IVH (ten patients); and group 3, those with apnea, SEp-IVH, and seizure activity for which they were receiving phenobarbital therapy (nine patients)." | 7.67 | Phenobarbital increases the theophylline requirement of premature infants being treated for apnea. ( Gottschalk, SK; Kissling, GE; Schuth, CR; Tran, TH; Yazdani, M, 1987) |
| "Theophylline, the bronchodilating agent, can cause life-threatening, generalized seizures when plasma concentrations exceed the usual therapeutic concentration range." | 7.67 | Kinetics of drug action in disease states. XVIII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Ramzan, IM, 1987) |
| "Four patients are reported who experienced seizures in association with serum theophylline concentrations which were in the mildly toxic range." | 7.67 | Theophylline-associated seizures in children. ( Brent, DK; Church, JA; Richards, W, 1985) |
| "Fifteen patients experienced theophylline-related seizures at our institution over the past 3 years." | 7.67 | Predisposing factors to apparent theophylline-induced seizures. ( Covelli, HD; Heppner, BT; Knodel, AR, 1985) |
| "This study investigates the ability of adenosine antagonists to reverse the anticonvulsant effects of carbamazepine on amygdala-kindled seizures in order to elucidate the possible physiological relevance of the potent effects of carbamazepine on adenosine receptors." | 7.67 | Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine. ( Marangos, PJ; Patel, J; Post, RM; Weiss, SR, 1985) |
| "The clinical features and management of theophylline-induced seizures are not well appreciated in spite of their unique aspects." | 7.66 | Theophylline-induced seizures: clinical and pathophysiologic aspects. ( Kwee, IL; Lerner, AM; Nakada, T; Remler, MP, 1983) |
| "Theophylline-induced seizures are reported in two neonates." | 7.66 | Theophylline-induced seizures in accidentally overdosed neonates. ( Erkan, NV; Gal, P; Robinson, H; Roop, C, 1980) |
| "Eight patients developed grand mal seizures during intravenous theophylline therapy." | 7.65 | Theophylline-induced seizures in adults. Correlation with serum concentrations. ( Cohn, WM; Matthay, RA; Neff, TA; Sutton, FD; Weinberger, MM; Zwillich, CW, 1975) |
| " Its positive impact in patients with lower maximum sustained coherence, in addition to the potential existence of a dose-response relationship, should be further investigated." | 5.42 | Impact of an oral theophylline loading dose pre-electroconvulsive therapy: a retrospective study in patients with missed or inadequate seizures. ( Allard, J; Kemp, MF; Marcotte, P; Pâquet, M, 2015) |
| "rats with a pentylenetetrazole-induced seizure score of 3 or more on a seizure scale ranging from 0 to 6) and death rate compared with those obtained for rats pre-treated with an equivalent intraperitoneal dose (140 mg kg-1) of acepifylline ('equivalent dose' referred to here denotes the theophylline content of the two preparations)." | 5.30 | A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1997) |
| " We report that cimetidine in doses that may cause pharmacokinetic interactions did not affect the concentration-effect relationship of either the stimulating action of theophylline or the depressant activity of ethanol." | 5.30 | The effect of cimetidine on the pharmacodynamics of theophylline-induced seizures and ethanol hypnotic activity. ( Gilhar, D; Habib, G; Hoffman, A; Perlstein, I; Pinto, E, 1999) |
| "When isbufylline-pretreated rats were challenged with pentylenetetrazole, the EEG was characterized by a short run of wave discharges (whose duration was shorter than that of other groups)." | 5.28 | Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study. ( Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S, 1992) |
| "The seizures were thought to be induced by theophylline toxicity, since serum theophylline concentration was high at 69." | 5.28 | [Theophylline toxicity in a patient with status asthmaticus]. ( Bando, T; Ishizaki, T; Kanamori, K; Mifune, J; Miyabo, S; Saitoh, Y; Sasaki, F, 1992) |
| " Pharmacokinetic studies demonstrated that THEO serum levels and elimination were not altered by concurrent CP administration." | 5.28 | Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. ( Schwark, WS; Vancutsem, PM, 1992) |
| "We induced generalized seizures by cortical injection of penicillin in anesthetized, paralyzed cats." | 5.28 | Role of endogenous adenosine in recurrent generalized seizures. ( Dowell, RT; Eldridge, FL; Paydarfar, D; Scott, SC, 1989) |
| "A wide spectrum of cardiac arrhythmias was observed during and following the seizures." | 5.26 | Caffeine- and aminophylline-induced seizures. ( Chu, NS, 1981) |
| ", doses of individual drugs) that induced seizure-like events, and identified diphenhydramine, enoxacin, strychnine and theophylline as "seizure-inducing" drugs, which have indeed been reported to induce seizures in clinical situations." | 4.98 | [Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect]. ( Gao, M; Ikegaya, Y; Sato, M, 2018) |
| "Clinical evidence, in particular the wide use of theophylline as a bronchodilator, suggests that methylxanthines can cause seizures in patients without known underlying epilepsy." | 4.87 | Methylxanthines, seizures, and excitotoxicity. ( Boison, D, 2011) |
| "Afebrile seizures associated with rotavirus gastroenteritis, respiratory syncytial virus bronchiolitis, influenza infection, asthma, blood transfusions, and intake of a number of drugs (including theophylline, cephalosporins, metronidazole, and acyclovir) with therapeutic drug levels are uncommonly encountered in clinical practice." | 4.85 | Common causes of uncommon seizures. ( Boustany, RM; El-Bitar, MK, 2009) |
| "We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures." | 4.85 | Seizures associated with levofloxacin: case presentation and literature review. ( Bellon, A; Chacko, RC; Coverdale, JH; Perez-Garcia, G, 2009) |
| "Theophylline-associated seizures (TAS) are considered a neurologic emergency, as they can sometimes be intractable and difficult to stop with standard treatments such as intravenous administration of diazepam." | 4.84 | First-line therapy for theophylline-associated seizures. ( Yoshikawa, H, 2007) |
| "Oral theophylline augmentation can be considered as an effective treatment option for patients undergoing ECT with inadequate seizures." | 4.12 | Oral theophylline augmentation for patients with missed or inadequate seizures with electroconvulsive therapy. ( Gon, J; Iwamoto, T; Kurata, A; Shimizu, H; Wada, K, 2022) |
| " She had bronchial asthma, was previously diagnosed with cerebral infarction, had experienced two events of convulsive status epilepticus, and was undergoing treatment with theophylline, levetiracetam, and clopidogrel." | 4.02 | [Nonconvulsive Status Epilepticus Associated with Theophylline: A Case Report]. ( Inoue, T; Kurokawa, K; Uemura, J; Yagita, Y; Yamashita, S, 2021) |
| "Treatment of apnea of prematurity with methylxanthines like caffeine, aminophylline or theophylline can evoke hippocampal seizures." | 3.81 | Methylxanthine-evoked perturbation of spontaneous and evoked activities in isolated newborn rat hippocampal networks. ( Ballanyi, K; Kantor, C; Kilb, W; Kuribayashi, J; Luhmann, HJ; Mildenberger, E; Ruangkittisakul, A; Sharopov, S, 2015) |
| "Adenosine has anticonvulsant effects in various models of seizures." | 3.80 | The role of alpha-2 adrenoceptors in the anticonvulsant effects of adenosine on pentylenetetrazole-induced seizure threshold in mice. ( Mansoori, E; Moezi, L; Niknahad, H; Shafaroodi, H, 2014) |
| "Clinical stimulation of preterm infant breathing with methylxanthines like caffeine and theophylline can evoke seizures." | 3.79 | Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons. ( Ballanyi, K; Iizuka, M; Kuribayashi, J; Leung, V; Panaitescu, B; Ruangkittisakul, A, 2013) |
| "Theophylline-associated convulsions are frequently exacerbated by fever, but the mechanisms behind it are still not completely understood." | 3.77 | Effect of heat exposure on aminophylline-induced convulsions in mice. ( Araki, H; Kawasaki, H; Ochi, R; Suemaru, K; Takechi, K; Watanabe, S; Yamaguchi, T, 2011) |
| "Theophylline-associated seizures (TAS) often progress to prolonged or treatment-resistant convulsions." | 3.76 | Adenosine A1 receptor blockage mediates theophylline-associated seizures. ( Fukuda, M; Hino, H; Ishii, E; Kuzume, K; Morimoto, T; Suzuki, Y, 2010) |
| "Theophylline can induce life-threatening seizures in humans, especially in infants, but the mechanism of induction remains unknown." | 3.76 | Theophylline-induced changes in mouse electroencephalograms. ( Kawakami, Y; Koizumi, S; Murashima, YL; Saito, K, 2010) |
| "We report a 70-year-old man who developed theophylline-associated seizure with postictal fever and postictal pleocytosis." | 3.76 | [A case of theophylline-associated seizures with postictal fever and postictal pleocytosis]. ( Mouri, W; Yaguchi, H; Yaguchi, M, 2010) |
| " Also, it was found to be protective against picrotoxin- and kainic acid-induced seizures." | 3.75 | Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog. ( Jain, R; Kaur, N; Krishnamoorthy, S; Meena, CL; Monga, V; Pawar, C; Rajput, SK; Sharma, SS, 2009) |
| "We presume it necessary to pay heed to fever and neurologic predispositions in order to prevent sequelae or death that may occur subsequently to seizures that developed during theophylline administration." | 3.74 | [Clinical review of patients with seizures that developed during theophylline administration--(III) Safety of theophylline examined in patients who had sequelae or died]. ( Kato, T; Nakano, H; Odajima, Y; Okada, K, 2008) |
| "Theophylline-associated seizures (TAS) are considered a neurologic emergency, as they can sometimes be intractable and difficult to stop with standard treatments such as intravenous administration of diazepam." | 3.74 | First-line therapy for theophylline-associated seizures. ( Yoshikawa, H, 2007) |
| "To elucidate the basic mechanism of theophylline-associated seizures (TAS), the clinical symptoms, electroencephalogram (EEG) and neuroradiological imaging of eight pediatric patients were all retrospectively evaluated." | 3.74 | Theophylline-associated seizures and their clinical characterizations. ( Izumi, T; Korematsu, S; Miyahara, H; Nagakura, T; Suenobu, S, 2008) |
| "We report an 81-year-old woman who suffered from theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency." | 3.74 | [Case of an 81-year-old woman with theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency]. ( Inaba, A; Kuwahara, H; Mizusawa, H; Noguchi, Y, 2008) |
| "In the present study, we investigated the effects of micro-injecting 2-chloroadenosine (2-CADO; an adenosine receptor agonist) into the thalamus alone and with theophylline (a nonspecific adenosine receptor antagonist) pretreatment on pentylenetetrazol (PTZ)-induced tonic-clonic seizures in male Wistar albino rats." | 3.73 | Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application. ( Ates, N; Ilbay, G; Sahin, D, 2005) |
| " The model was used to characterize the additivity (or non-additivity) of norfloxacin, pefloxacin, and theophylline in causing maximal seizures in male Sprague Dawley rats." | 3.72 | Extension of the isobolographic approach to interactions studies between more than two drugs: illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats. ( Bois, FY; Brochot, C; Couet, W; Gelman, A; Marchand, S, 2004) |
| " In the presence of 8-cyclopentyl-1,3-dimethylxanthine (CPT), an adenosine A(1) receptor antagonist, the occurrence of spontaneous seizure activity was greatly increased as was the duration and intensity of evoked seizures, whilst the postictal depression of basal synaptic transmission was greatly attenuated." | 3.72 | Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. ( Etherington, LA; Frenguelli, BG, 2004) |
| "The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats." | 3.71 | Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. ( Chaudhary, G; Gupta, YK; Srivastava, AK, 2002) |
| " The estimates of a suggested a Loewe antagonistic interaction between pefloxacin and theophylline at the induction of maximal seizures in rats." | 3.70 | Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats. ( Bouquet, S; Couet, W; Delon, A; Faury, P; Greco, WR; Levasseur, LM, 1998) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 3.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| "Effects of Saiko-ka-ryukotsu-borei-to (SRBT) on theophylline-induced tachycardia in anesthetized rats and theophylline-induced locomotion and convulsions in mice were examined." | 3.70 | Effects of Saiko-ka-ryukotsu-borei-to, a Japanese Kampo medicine, on tachycardia and central nervous system stimulation induced by theophylline in rats and mice. ( Chisaki, K; Hayashi, H; Komatsu, Y; Sanae, F, 1999) |
| "Despite the declining use of theophylline, episodes of intoxication continue to occur, producing seizures, arrhythmias, and death." | 3.70 | Life-threatening events after theophylline overdose: a 10-year prospective analysis. ( Shannon, M, 1999) |
| " The present study was conducted to determine if the adenosinergic system and adenosine A1 receptors are involved in the anticonvulsant action of the antiepileptic drugs phenobarbitone and carbamazepine, in pentylenetetrazole (PTZ)-induced seizures in rats." | 3.70 | Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine. ( Gupta, YK; Malhotra, J, 1999) |
| "Isoniazid-induced seizures respond poorly to anticonvulsants but well to pyridoxine (Vitamin B6); theophylline produces difficult-to-treat seizures with substantial morbidity and mortality." | 3.70 | Seizures induced by theophylline and isoniazid in mice. ( Bonner, AB; Peterson, SL; Weir, MR, 1999) |
| "Seizures is a major toxicity of theophylline." | 3.70 | Influence of adenosine agonists and antiepileptic drugs on theophylline-induced seizures in rats. ( Gupta, YK; Malhotra, J, 1998) |
| "In order to study whether a theophylline-related seizure is caused by a decrease in serum vitamin B6, serum pyridoxal (PAL) levels were measured in children with bronchial asthma treated with theophylline." | 3.70 | [Depression of serum pyridoxal levels in theophylline-related seizures]. ( Furukawa, K; Hattori, H; Hayashi, K; Inada, H; Isshiki, G; Kobayashi, N; Matsuoka, O; Seto, T; Tada, H, 2000) |
| "To evaluate the potential anticonvulsant effects of Adenocard in theophylline-induced seizures, we developed a rodent model of theophylline neurotoxicity with resultant convulsions." | 3.69 | Anticonvulsant effects of intracerebroventricular adenocard in theophylline-induced seizures. ( Maher, T; Shannon, M, 1995) |
| "The purpose of the present investigation was to evaluate whether antiinflammatory drugs affect the pharmacodynamics of theophylline-induced seizures." | 3.69 | Differential effects of various antiinflammatory drugs on theophylline neurotoxicity. ( Afargan, M; Backon, J; Gilhar, D; Hoffman, A; Pinto, E, 1994) |
| "One of the most dangerous aspects of theophylline toxicity is seizures." | 3.69 | Adenosine receptors are not involved in theophylline-induced seizures. ( Hornfeldt, CS; Larson, AA, 1994) |
| " In particular, theophylline-induced seizures, which are often fatal and occur unpredictably over a wide range of serum theophylline concentrations, may be precipitated." | 3.69 | Cyclosporine enhances theophylline neurotoxicity in rats. ( Afargan, M; Hoffman, A; Pinto, E; Schattner, A, 1994) |
| "Two patients developed a disabling amnesic syndrome after seizures associated with oral theophylline treatment." | 3.69 | Amnesic syndrome after theophylline associated seizures: iatrogenic brain injury. ( FitzGerald, MX; Hutchinson, J; Hutchinson, M; O'Riordan, JI, 1994) |
| "Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat." | 3.69 | Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995) |
| " The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats." | 3.69 | Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "Seizures, often with fatal outcome, are a manifestation of pronounced theophylline toxicity." | 3.68 | Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat. ( Gilhar, D; Hoffman, A; Pinto, E, 1993) |
| "The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline." | 3.68 | Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993) |
| "4 nmol) against bicuculline methiodide-induced seizures, and these anticonvulsant effects were significantly potentiated by treatment with an adenosine kinase inhibitor, 5'-amino-5'-deoxyadenosine; by the adenosine transport blockers, dilazep or nitrobenzylthioinosine 5'-monophosphate; and by an adenosine deaminase inhibitor, 2'-deoxycoformycin." | 3.68 | Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility. ( Franklin, PH; Murray, TF; Zhang, G, 1993) |
| "We report 12 adults with seizures associated with serum theophylline levels between 14 and 35 mg/l." | 3.68 | Theophylline-associated seizures with "therapeutic" or low toxic serum concentrations: risk factors for serious outcome in adults. ( Bahls, FH; Bird, TD; Ma, KK, 1991) |
| "The anticonvulsant actions of the adenosine receptor agonists, 1-phenylisopropyladenosine, 2-chloroadenosine and cyclohexyl-adenosine, against DMCM (methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate)-induced seizures in mice were studied with an infusion technique." | 3.68 | Selective protection by adenosine receptor agonists against DMCM-induced seizures. ( Petersen, EN, 1991) |
| "Five patients had apparently drug-induced seizures while simultaneously receiving theophylline and either imipenem (three patients), ciprofloxacin (one patient), or ciprofloxacin and metronidazole (one patient)." | 3.68 | Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole. ( Allen, N; Semel, JD, 1991) |
| " Its protective efficacy against theophylline-induced seizures was determined in this investigation in view of the limited effectiveness of presently available anticonvulsants against this manifestation of serious theophylline intoxication." | 3.68 | Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "Two aged patients with bronchial asthma and chronic obstructive pulmonary disease who suffered convulsions that resulted in permanent brain damage during treatment with the recommended therapeutic dose of theophylline are presented here." | 3.68 | Permanent brain damage possibly caused by theophylline in two elderly patients with airway obstruction. ( Aikawa, T; Fukushima, T; Itabashi, S; Sasaki, H; Sekizawa, K; Yanai, M, 1990) |
| "The mechanism of action of aminophylline in prolonging seizures was tested in amygdala-kindled rats." | 3.68 | Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. ( Dragunow, M, 1990) |
| "To identify risk factors for the development of seizures and cardiac arrhythmias after chronic, unintentional theophylline intoxication we monitored the clinical course of 72 consecutive patients referred to a regional poison center with chronic theophylline intoxication (serum theophylline concentration, greater than or equal to 167 mumol/L after protracted use)." | 3.68 | The influence of age vs peak serum concentration on life-threatening events after chronic theophylline intoxication. ( Lovejoy, FH; Shannon, M, 1990) |
| "Caffeine as well as the antiasthmatic drug theophylline can cause seizures when administered to humans or animals in excessive doses." | 3.68 | Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats. ( Levy, G; Zhi, JG, 1990) |
| "Hippocampal and neocortical blood flows and tissue pO2 were investigated by mass spectrometry in unanaesthetized spontaneously breathing rats during kainic acid-induced seizures to determine whether adenosine is involved in the coupling of cerebral blood flow to metabolism during enhanced metabolic demand." | 3.68 | Theophylline reduces cerebral hyperaemia and enhances brain damage induced by seizures. ( Pinard, E; Puiroud, S; Riche, D; Seylaz, J, 1990) |
| "Kainic acid (KA), microinjected unilaterally into the rat prepiriform cortex (PC), produces generalized motor seizures in a dose-dependent manner." | 3.68 | Anticonvulsant effect of N-ethylcarboxamidoadenosine against kainic acid-induced behavioral seizures in the rat prepiriform cortex. ( Franklin, PH; Murray, TF; Zhang, G, 1990) |
| "The presenting symptoms, course, and treatment of 10 patients with severe theophylline toxicity (heart rate above 120, multifocal atrial tachycardia or premature ventricular contractions, hypotension, seizures) are described." | 3.67 | Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents, and charcoal hemoperfusion. ( Greenberg, A; Kroboth, PD; Piraino, BH; Weiss, J, 1984) |
| " infusion of theophylline until the onset of maximal seizures had no significant effect on the total dose and the serum and cerebrospinal fluid concentrations of theophylline at the pharmacologic endpoint." | 3.67 | Aspartame and phenylalanine do not enhance theophylline-induced seizures in rats. ( Levy, G; Zhi, JQ, 1989) |
| " The effects of papaverine, an adenosine uptake inhibitor, were tested against theophylline-induced seizures." | 3.67 | Proconvulsant effect of papaverine on theophylline-induced seizures in rats. ( Ramzan, I, 1989) |
| "Six patients treated with theophylline, including five with advanced chronic obstructive pulmonary disease, developed generalized seizures with serum theophylline concentrations ranging from 7 to 21 mg/l." | 3.67 | [Onset of convulsive crises with theophylline therapy at therapeutic doses]. ( Furet, Y; Ged, E; Ginies, G; Lebret, P; Perrotin, D, 1988) |
| "The effects of various metabolically-stable analogs of adenosine on the threshold for seizures in rats was determined by measuring the dose of pentylenetetrazol (PTZ), infused through a tail vein, required to elicit a myoclonic jerk." | 3.67 | Purinergic modulation of the seizure threshold for pentylenetetrazol in the rat. ( Murray, TF; Schultz, CS; Sylvester, D; Szot, P, 1985) |
| "This investigation was designed to determine the effect of fever on the neurotoxicity of theophylline as reflected by the concentrations of this drug that cause convulsions in experimental animals." | 3.67 | Kinetics of drug action in disease states. XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Yasuhara, M, 1988) |
| "We evaluated the efficacy of pretreatment with phenytoin and phenobarbital to prevent seizures in mice given convulsive doses of theophylline." | 3.67 | Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice. ( Blake, KV; Hendeles, L; Massey, KL; Neims, A; Nickerson, D, 1988) |
| "Generalized seizures may be associated with therapeutic or intentional theophylline overdose." | 3.67 | The effect of serum potassium on theophylline-induced seizures. ( Adler, S; Borok, Z; Fraley, DS; Schneider, SM, 1988) |
| "Theophylline can cause life-threatening seizures when administered in excessive doses." | 3.67 | Caffeine as a potential risk factor for theophylline neurotoxicity. ( Levy, G; Yasuhara, M, 1988) |
| "The purpose of this investigation was to determine whether the neurotoxicity of theophylline is altered in advanced pregnancy." | 3.67 | Theophylline neurotoxicity in pregnant rats. ( DeDonato, V; Ramzan, I, 1988) |
| "Seizures, often with fatal outcome, are a manifestation of pronounced theophylline intoxication." | 3.67 | Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Ramzan, IM, 1986) |
| "There are pronounced interindividual differences in the neurotoxicity of theophylline in humans as reflected by the wide range of plasma theophylline concentrations associated with the occurrence of life-threatening, generalized seizures in patients treated with this widely used bronchodilator." | 3.67 | Kinetics of drug action in disease states. XIX. Effect of experimental liver disease on the neurotoxicity of theophylline in rats. ( Levy, G; Ramzan, IM; Yasuhara, M, 1987) |
| "Theophylline, the widely used antiasthmatic drug, can cause life-threatening, generalized seizures when administered in excessive doses." | 3.67 | Chronic theophylline administration has no apparent effect on theophylline concentrations required to produce seizures in rats. ( Levy, G; Ramzan, IM, 1986) |
| "As in humans, theophylline intoxication in rabbits causes seizures and death." | 3.67 | Phenobarbital improves survival in theophylline-intoxicated rabbits. ( Goldberg, MJ; Miller, G; Spector, R, 1986) |
| " If no cause is found, the diagnosis of idiopathic infantile apnea is made." | 3.67 | Infantile apnea. ( McCulloch, K; Vidyasagar, D, 1986) |
| "To determine the effect of phenobarbital sodium therapy and subependymal intraventricular hemorrhage (SEp-IVH) on the theophylline requirement of premature infants suffering with apnea and seizure activity, we compared three groups of patients as follows: group 1, those with apnea of prematurity (ten patients); group 2, those with apnea and SEp-IVH (ten patients); and group 3, those with apnea, SEp-IVH, and seizure activity for which they were receiving phenobarbital therapy (nine patients)." | 3.67 | Phenobarbital increases the theophylline requirement of premature infants being treated for apnea. ( Gottschalk, SK; Kissling, GE; Schuth, CR; Tran, TH; Yazdani, M, 1987) |
| "Theophylline, the bronchodilating agent, can cause life-threatening, generalized seizures when plasma concentrations exceed the usual therapeutic concentration range." | 3.67 | Kinetics of drug action in disease states. XVIII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Ramzan, IM, 1987) |
| "Four patients are reported who experienced seizures in association with serum theophylline concentrations which were in the mildly toxic range." | 3.67 | Theophylline-associated seizures in children. ( Brent, DK; Church, JA; Richards, W, 1985) |
| "Fifteen patients experienced theophylline-related seizures at our institution over the past 3 years." | 3.67 | Predisposing factors to apparent theophylline-induced seizures. ( Covelli, HD; Heppner, BT; Knodel, AR, 1985) |
| "Ten ambulatory subjects with asthma experienced a seizure while they were receiving oral theophylline preparations and were evaluated prospectively according to a set protocol." | 3.67 | The relationship of cerebrospinal fluid and plasma theophylline concentrations in children and adolescents taking theophylline. ( Auritt, WA; Mansmann, HC; McGeady, SJ, 1985) |
| "This study investigates the ability of adenosine antagonists to reverse the anticonvulsant effects of carbamazepine on amygdala-kindled seizures in order to elucidate the possible physiological relevance of the potent effects of carbamazepine on adenosine receptors." | 3.67 | Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine. ( Marangos, PJ; Patel, J; Post, RM; Weiss, SR, 1985) |
| "A pediatric patient who was taking carefully monitored doses of theophylline for chronic asthma, was placed on erythromycin base for bronchitis." | 3.66 | Interaction of theophylline with erythromycin base in a patient with seizure activity. ( Burns, RM; Haulman, NJ; Parish, RA, 1983) |
| "The clinical features and management of theophylline-induced seizures are not well appreciated in spite of their unique aspects." | 3.66 | Theophylline-induced seizures: clinical and pathophysiologic aspects. ( Kwee, IL; Lerner, AM; Nakada, T; Remler, MP, 1983) |
| "During the 1980 influenza B outbreak in King County, Washington, 11 children whose asthma had previously been controlled with a stable theophylline dose, developed theophylline toxicity on this same dose." | 3.66 | Altered theophylline clearance during an influenza B outbreak. ( Bierman, CW; Furukawa, CT; Koup, JR; Kraemer, MJ; Pierson, WE; Shapiro, GG, 1982) |
| "Theophylline-induced seizures are reported in two neonates." | 3.66 | Theophylline-induced seizures in accidentally overdosed neonates. ( Erkan, NV; Gal, P; Robinson, H; Roop, C, 1980) |
| "Eight patients developed grand mal seizures during intravenous theophylline therapy." | 3.65 | Theophylline-induced seizures in adults. Correlation with serum concentrations. ( Cohn, WM; Matthay, RA; Neff, TA; Sutton, FD; Weinberger, MM; Zwillich, CW, 1975) |
| "Fenethylline is a theophylline derivative of amphetamine having stimulant effects similar to those of other amphetamine-type derivatives." | 2.53 | Fenethylline (Captagon) Abuse - Local Problems from an Old Drug Become Universal. ( Athanaselis, S; Katselou, M; Nikolaou, P; Papoutsis, I; Qammaz, S; Spiliopoulou, C, 2016) |
| "Seizures are commonly encountered in patients who do not have epilepsy." | 2.40 | Medical causes of seizures. ( Delanty, N; French, JA; Vaughan, CJ, 1998) |
| "Drug-induced seizures are a potentially serious adverse effect." | 2.39 | Drug-induced seizures in the elderly. Causative agents and optimal management. ( Chatel, DM; Dahdal, WY; Franson, KL; Grossberg, GT; Hay, DP; Kotegal, S; Mirza, WU; Neppe, V; Szwabo, PA, 1995) |
| " One or more toxic manifestations were present in 109 (94%) cases." | 2.38 | Theophylline toxicity: clinical features of 116 consecutive cases. ( Sessler, CN, 1990) |
| "Enprofylline is a more potent smooth muscle relaxant and antiasthmatic drug than theophylline but does not produce, e." | 2.37 | Effects of enprofylline and theophylline may show the role of adenosine. ( Andersson, KE; Kjellin, G; Persson, CG, 1986) |
| "Cardiac monitoring and seizure precautions are recommended." | 2.37 | Evaluation of theophylline overdoses and toxicities. ( Paloucek, FP; Rodvold, KA, 1988) |
| " In our case, the theophylline dosage was approximately half the amount described in previous reports." | 1.62 | Severe pallid breath-holding spells treated with low-dose theophylline. ( Asakai, H; Oda, Y; Sato, A, 2021) |
| "Congestive cardiac failure, congestive liver disease and polypharmacy were factors isolated from this case that expedited the patients' development of theophylline toxicity." | 1.43 | Case Report: The risks associated with chronic theophylline therapy and measures designed to improve monitoring and management. ( Hopkins, ME; MacKenzie-Ross, RV, 2016) |
| "Theophylline poisoning generally occurs due to acute high dose intake as well as chronic intake of the medication." | 1.43 | Severe theophylline poisoning treated with continuous venovenous hemodialysis in a child. ( Azapağası, E; Erkol, H; Kendirli, T; Ödek, Ç; Pişkin, İE; Teber-Tıraş, S; Yalçınkaya, F; Yaman, A, 2016) |
| " Its positive impact in patients with lower maximum sustained coherence, in addition to the potential existence of a dose-response relationship, should be further investigated." | 1.42 | Impact of an oral theophylline loading dose pre-electroconvulsive therapy: a retrospective study in patients with missed or inadequate seizures. ( Allard, J; Kemp, MF; Marcotte, P; Pâquet, M, 2015) |
| "During drug development, seizure threshold tests are widely used to identify potential proconvulsant activity of investigational drugs." | 1.38 | Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models. ( Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W, 2012) |
| "Adenosine is an endogenous inhibitor of excitatory synaptic transmission with potent anticonvulsant properties in the mammalian brain." | 1.35 | Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. ( Boison, D; Dale, N; Etherington, LA; Frenguelli, BG; Irving, AJ; Meechan, L; Patterson, GE, 2009) |
| " Theophylline, a re-emerging drug for the treatment of obstructive airway disease, has a narrow therapeutic index which precludes its safe use." | 1.34 | Free radicals and theophylline neurotoxicity : an experimental study. ( Gulati, K; Ray, A; Vijayan, VK, 2007) |
| "in untreated and in theophylline-treated male mice (50 mg/kg i." | 1.31 | Long-term theophylline treatment changes the effects of angiotensin II and adenosinergic agents on the seizure threshold. ( Georgiev, V; Kambourova, T; Tchekalarova, J, 2000) |
| "The cause of theophylline-induced convulsions is not clear, but antagonism of the inhibitory nervous system may be implicated, so we examined the effects of theophylline on GABA-induced currents using recombinant GABA(A) receptor (GABA(A)-R)." | 1.31 | Inhibitory effect of theophylline on recombinant GABA(A) receptor. ( Mashimo, T; Okada, S; Sugimoto, M; Sugimoto, T; Uchida, I, 2001) |
| "These findings showed that the quantitative isobolographic approach is appropriate to assess the nature and intensity of the pharmacodynamic interaction between two drugs when data are collected within the biophase, but that data interpretation outside the biophase can be risky due to further pharmacokinetic complexities, in particular slow or/and nonlinear diffusion into the biophase." | 1.31 | Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin-theophylline convulsant interaction in rats. ( Bouquet, S; Cadart, M; Couet, W; Marchand, S; Pariat, C, 2002) |
| "We tested the effects of electrographic seizures (EGSs) elicited in a remote site (area CA3) on the induction of long-term potentiation (LTP) in area CA1 of the rat hippocampal slice." | 1.30 | Post-ictal depression transiently inhibits induction of LTP in area CA1 of the rat hippocampal slice. ( Barr, DS; Hoyt, KL; Moore, SD; Wilson, WA, 1997) |
| "rats with a pentylenetetrazole-induced seizure score of 3 or more on a seizure scale ranging from 0 to 6) and death rate compared with those obtained for rats pre-treated with an equivalent intraperitoneal dose (140 mg kg-1) of acepifylline ('equivalent dose' referred to here denotes the theophylline content of the two preparations)." | 1.30 | A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1997) |
| " We report that cimetidine in doses that may cause pharmacokinetic interactions did not affect the concentration-effect relationship of either the stimulating action of theophylline or the depressant activity of ethanol." | 1.30 | The effect of cimetidine on the pharmacodynamics of theophylline-induced seizures and ethanol hypnotic activity. ( Gilhar, D; Habib, G; Hoffman, A; Perlstein, I; Pinto, E, 1999) |
| "8-CPT did not antagonize the seizure protection afforded by CBZ or SV." | 1.29 | Involvement of adenosine in postictal events in rats given electroshock. ( David, J; Joseph, T; Kulkarni, C, 1994) |
| "Of 233 charts coded as involving seizures, 191 occurred in humans and were available for analysis." | 1.29 | Seizures associated with poisoning and drug overdose. ( Benowitz, NL; Blanc, PD; Dyer, JE; Kearney, TE; Olson, KR, 1993) |
| "Theophylline has been a mainstay of asthma therapy despite its narrow therapeutic index, which makes toxicity a common problem." | 1.29 | Theophylline toxicity in children: a retrospective review. ( Powell, EC; Reynolds, SL; Rubenstein, JS, 1993) |
| "All compounds studied induced clonic convulsion in a dose-dependent manner, and the ED50 values for convulsion were 490, 546, 1107, 360 and 620 nmol/kg for theophylline, 1-MX, 3-MX, 1,3-DMUA and 1-MUA, respectively." | 1.29 | Neurotoxic convulsions induced by theophylline and its metabolites in mice. ( Iga, T; Kawakami, J; Sawada, Y; Toyama, E; Yamamoto, K, 1996) |
| "Nitric oxide may be involved in seizure phenomena even though data often seem to be contradictory." | 1.29 | NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice. ( Borowicz, KK; Błaszczak, P; Czuczwar, SJ; Drelewska, E; Kleinrok, Z; Urbańska, EM, 1996) |
| "When isbufylline-pretreated rats were challenged with pentylenetetrazole, the EEG was characterized by a short run of wave discharges (whose duration was shorter than that of other groups)." | 1.28 | Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study. ( Bortot, L; Cutrufo, C; Giachetti, A; Manzini, S, 1992) |
| "The seizures were thought to be induced by theophylline toxicity, since serum theophylline concentration was high at 69." | 1.28 | [Theophylline toxicity in a patient with status asthmaticus]. ( Bando, T; Ishizaki, T; Kanamori, K; Mifune, J; Miyabo, S; Saitoh, Y; Sasaki, F, 1992) |
| " Pharmacokinetic studies demonstrated that THEO serum levels and elimination were not altered by concurrent CP administration." | 1.28 | Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study. ( Schwark, WS; Vancutsem, PM, 1992) |
| "To report unusually high theophylline dosing requirements in a smoker receiving concomitant therapy with phenytoin and phenobarbital." | 1.28 | Massive theophylline dosing in a heavy smoker receiving both phenytoin and phenobarbital. ( Basile, SA; Cury, JD; Nicholson, JP, 1992) |
| "Severe vomiting was present in 34 (89%) and proved to be a serious obstacle to the administration of enteral charcoal." | 1.28 | Management of theophylline overdose patients in the intensive care unit. ( Henderson, A; Pond, SM; Wright, DM, 1992) |
| "Although life-threatening events (seizures or arrhythmias) occurred at a similar rate across categories, the (theo) at which these events occurred was significantly higher in patients with acute intoxication than in those with chronic intoxication (100 vs 42 micrograms/ml; p = 0." | 1.28 | Effect of acute versus chronic intoxication on clinical features of theophylline poisoning in children. ( Lovejoy, FH; Shannon, M, 1992) |
| "Pretreatment with adenosinergic agents and MK-801 markedly enhanced the protective effect of the stable analogs of adenosine namely, 2-chloroadenosine and N6-cyclohexyladenosine." | 1.28 | Effect of MK-801 and its interaction with adenosinergic agents and carbamazepine against hypoxic stress-induced convulsions and death in mice. ( Kulkarni, SK; Thorat, SN, 1990) |
| "Glycerol acute renal failure (ARF) was examined to see if it alters theophylline (Th) neurotoxicity in rats." | 1.28 | Theophylline neurotoxicity is unaffected by glycerol-induced renal failure. ( Ramzan, I, 1990) |
| "Seven patients had new supraventricular arrhythmias with levels of 21 to 40 micrograms/mL." | 1.28 | Risk of toxicity in patients with elevated theophylline levels. ( Connors, AF; Devlin, C; Emerman, CL, 1990) |
| "Ciprofloxacin has been reported to cause theophylline toxicity by inhibiting theophylline metabolism." | 1.28 | Seizure with ciprofloxacin and theophylline combined therapy. ( Bentley, DW; Karki, SD; Raghavan, M, 1990) |
| "Theophylline was markedly less potent than any of the other agents." | 1.28 | Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig. ( Cowlrick, IS; Paciorek, PM; Perkins, RS; Taylor, JC; Waterfall, JF; Wilkinson, GF, 1990) |
| "When phenobarbital was infused about 2." | 1.28 | Kinetics of drug action in disease states. XXXVII. Effects of acute fluid overload and water deprivation on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline in rats. ( Levy, G; Zhi, JG, 1989) |
| "Alterations in seizure threshold followed a similar temporal pattern of development." | 1.28 | Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats. ( Murray, TF; Sanders, RC, 1989) |
| "Concomitant use of the bronchodilator theophylline and the antibacterial agent enoxacin has been associated with significant neurologic and other adverse effects." | 1.28 | Effect of enoxacin on theophylline neurotoxicity. ( Hoffman, A; Levy, G, 1989) |
| "We induced generalized seizures by cortical injection of penicillin in anesthetized, paralyzed cats." | 1.28 | Role of endogenous adenosine in recurrent generalized seizures. ( Dowell, RT; Eldridge, FL; Paydarfar, D; Scott, SC, 1989) |
| "Theophylline pretreatment failed to alter anticonvulsant protection by trimethadione and sodium valproate, but significantly decreased the anticonvulsant effects of carbamazepine and phenobarbital." | 1.27 | Interactions of the anticonvulsant carbamazepine with adenosine receptors. 2. Pharmacological studies. ( Chow, SC; Johnston, GA; Skerritt, JH, 1983) |
| " Dosing errors accounted for the majority of cases." | 1.27 | Theophylline toxicity in children. ( Baker, MD, 1986) |
| " No relationship between the serum concentrations and the severity of toxic effect was seen." | 1.27 | Reassessment of theophylline toxicity. Serum concentrations, clinical course, and treatment. ( Bertino, JS; Walker, JW, 1987) |
| "To evaluate empiric dosing guidelines for aminophylline and phenytoin in the management of acute exacerbations of obstructive lung disease and seizure disorders, we utilized an emergency department (ED)-based EMIT system to measure stat plasma theophylline and phenytoin levels in patients intended to receive these drugs." | 1.27 | Effect of empiric dosing on blood levels of theophylline and phenytoin. ( Bederka, J; Curtis, RA; Hutchinson, RA; Troyer, WG, 1985) |
| "Prolonged focal seizures with secondary generalization resulted in hemiparesis and developmental retardation, and CT demonstrated cerebral hemiatrophy." | 1.27 | Theophylline neurotoxicity resulting in significant unilateral brain-damage. ( Noetzel, MJ, 1985) |
| "Four patients had seizures attributable to theophylline toxicity; all four had serum theophylline concentrations above 40 micrograms/ml." | 1.26 | Evaluation of "toxic" serum theophylline concentrations. ( Burkle, WS; Gwizdala, CJ, 1981) |
| "Theophylline has not been proved effective for the treatment of bronchiolitis." | 1.26 | Theophylline toxicity in term infants. ( Friesen, FR; Simons, FE; Simons, KJ, 1980) |
| "A wide spectrum of cardiac arrhythmias was observed during and following the seizures." | 1.26 | Caffeine- and aminophylline-induced seizures. ( Chu, NS, 1981) |
| "Papaverine in low doses was ineffective, but in higher doses lowered PSAT; it antagonized the effect of GAMA, elevating the threshold." | 1.26 | [Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam]. ( Georgiev, V, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 91 (42.72) | 18.7374 |
| 1990's | 75 (35.21) | 18.2507 |
| 2000's | 26 (12.21) | 29.6817 |
| 2010's | 17 (7.98) | 24.3611 |
| 2020's | 4 (1.88) | 2.80 |
| Authors | Studies |
|---|---|
| Wada, K | 1 |
| Kurata, A | 1 |
| Iwamoto, T | 1 |
| Gon, J | 1 |
| Shimizu, H | 2 |
| Dai, AI | 1 |
| Demiryürek, AT | 1 |
| Sato, A | 1 |
| Oda, Y | 1 |
| Asakai, H | 1 |
| Uemura, J | 1 |
| Yamashita, S | 1 |
| Kurokawa, K | 1 |
| Yagita, Y | 1 |
| Inoue, T | 1 |
| Tzabazis, A | 1 |
| Wiernik, ME | 1 |
| Wielopolski, J | 1 |
| Sperling, W | 1 |
| Ihmsen, H | 1 |
| Schmitt, HJ | 1 |
| Münster, T | 1 |
| Gao, M | 2 |
| Sato, M | 1 |
| Ikegaya, Y | 2 |
| Carano, N | 1 |
| Bo, I | 1 |
| Zanetti, E | 1 |
| Tchana, B | 1 |
| Barbato, G | 1 |
| Agnetti, A | 1 |
| Panaitescu, B | 1 |
| Kuribayashi, J | 2 |
| Ruangkittisakul, A | 2 |
| Leung, V | 1 |
| Iizuka, M | 1 |
| Ballanyi, K | 2 |
| Kemp, MF | 1 |
| Allard, J | 1 |
| Pâquet, M | 1 |
| Marcotte, P | 1 |
| Moezi, L | 1 |
| Mansoori, E | 1 |
| Niknahad, H | 1 |
| Shafaroodi, H | 1 |
| Sharopov, S | 1 |
| Kantor, C | 1 |
| Mildenberger, E | 1 |
| Luhmann, HJ | 1 |
| Kilb, W | 1 |
| Hopkins, ME | 1 |
| MacKenzie-Ross, RV | 1 |
| Katselou, M | 1 |
| Papoutsis, I | 1 |
| Nikolaou, P | 1 |
| Qammaz, S | 1 |
| Spiliopoulou, C | 1 |
| Athanaselis, S | 1 |
| Igata, H | 1 |
| Takeuchi, A | 1 |
| Sato, K | 1 |
| Yaman, A | 1 |
| Kendirli, T | 1 |
| Ödek, Ç | 1 |
| Azapağası, E | 1 |
| Erkol, H | 1 |
| Pişkin, İE | 1 |
| Teber-Tıraş, S | 1 |
| Yalçınkaya, F | 1 |
| Odajima, Y | 2 |
| Nakano, H | 2 |
| Kato, T | 2 |
| Okada, K | 2 |
| Rajput, SK | 1 |
| Krishnamoorthy, S | 1 |
| Pawar, C | 1 |
| Kaur, N | 1 |
| Monga, V | 1 |
| Meena, CL | 1 |
| Jain, R | 1 |
| Sharma, SS | 1 |
| Etherington, LA | 2 |
| Patterson, GE | 1 |
| Meechan, L | 1 |
| Boison, D | 2 |
| Irving, AJ | 1 |
| Dale, N | 1 |
| Frenguelli, BG | 2 |
| El-Bitar, MK | 1 |
| Boustany, RM | 1 |
| Bellon, A | 1 |
| Perez-Garcia, G | 1 |
| Coverdale, JH | 1 |
| Chacko, RC | 1 |
| Fukuda, M | 1 |
| Suzuki, Y | 1 |
| Hino, H | 1 |
| Kuzume, K | 1 |
| Morimoto, T | 1 |
| Ishii, E | 1 |
| Koizumi, S | 1 |
| Saito, K | 1 |
| Murashima, YL | 1 |
| Kawakami, Y | 1 |
| Yaguchi, M | 1 |
| Yaguchi, H | 1 |
| Mouri, W | 1 |
| Ochi, R | 1 |
| Suemaru, K | 1 |
| Watanabe, S | 1 |
| Yamaguchi, T | 1 |
| Takechi, K | 1 |
| Kawasaki, H | 1 |
| Araki, H | 1 |
| Bankstahl, M | 1 |
| Bankstahl, JP | 1 |
| Bloms-Funke, P | 1 |
| Löscher, W | 1 |
| Pawłowski, M | 1 |
| Katlabi, J | 1 |
| Jurczyk, S | 1 |
| Malec, D | 1 |
| Modzelewski, J | 1 |
| Srivastava, AK | 2 |
| Malhotra, J | 4 |
| Gupta, YK | 5 |
| FROEHLICH, A | 1 |
| MCCOLL, JD | 1 |
| PARKER, JM | 1 |
| FERGUSON, JK | 1 |
| HAMZA, B | 1 |
| JEDIDI, H | 1 |
| BOUHAHA, M | 1 |
| BESSON, H | 1 |
| DEBAY, A | 1 |
| BRAUDE, MC | 1 |
| KRANTZ, JC | 1 |
| MUELLER, WK | 1 |
| Brochot, C | 1 |
| Marchand, S | 2 |
| Couet, W | 3 |
| Gelman, A | 1 |
| Bois, FY | 1 |
| JOHNS, RJ | 1 |
| BALES, PD | 1 |
| HIMWICH, HE | 1 |
| Ates, N | 1 |
| Ilbay, G | 1 |
| Sahin, D | 1 |
| Rezvani, ME | 1 |
| Mirnajafi-Zadeh, J | 1 |
| Fathollahi, Y | 1 |
| Palizvan, MR | 1 |
| Yoshikawa, H | 3 |
| Gulati, K | 1 |
| Ray, A | 1 |
| Vijayan, VK | 1 |
| Korematsu, S | 1 |
| Miyahara, H | 1 |
| Nagakura, T | 1 |
| Suenobu, S | 1 |
| Izumi, T | 1 |
| Kuwahara, H | 1 |
| Noguchi, Y | 1 |
| Inaba, A | 1 |
| Mizusawa, H | 1 |
| Jensen, MH | 1 |
| Jørgensen, S | 1 |
| Nielsen, H | 1 |
| Sanchez, R | 1 |
| Andersen, PK | 1 |
| Bauman, JH | 1 |
| Kimelblatt, BJ | 1 |
| Caraccio, TR | 1 |
| Silverman, HM | 1 |
| Simon, GI | 1 |
| Beck, GJ | 1 |
| Stirt, JA | 1 |
| Sullivan, SF | 1 |
| Folbergrová, J | 2 |
| Persson, CG | 3 |
| Skerritt, JH | 1 |
| Johnston, GA | 1 |
| Chow, SC | 1 |
| Hall, KW | 1 |
| Dobson, KE | 1 |
| Dalton, JG | 1 |
| Ghignone, MC | 1 |
| Penner, SB | 1 |
| Woo, OF | 2 |
| Pond, SM | 3 |
| Benowitz, NL | 3 |
| Olson, KR | 3 |
| Parish, RA | 1 |
| Haulman, NJ | 1 |
| Burns, RM | 1 |
| Greenberg, A | 1 |
| Piraino, BH | 1 |
| Kroboth, PD | 1 |
| Weiss, J | 1 |
| Weinberger, M | 1 |
| Gaudreault, P | 1 |
| Wason, S | 1 |
| Lovejoy, FH | 3 |
| Sahney, S | 1 |
| Abarzua, J | 1 |
| Sessums, L | 1 |
| Nakada, T | 1 |
| Kwee, IL | 1 |
| Lerner, AM | 1 |
| Remler, MP | 1 |
| Park, GD | 1 |
| Spector, R | 2 |
| Roberts, RJ | 1 |
| Goldberg, MJ | 2 |
| Weismann, D | 1 |
| Stillerman, A | 1 |
| Flanigan, MJ | 1 |
| Haddad, ZH | 1 |
| Sakai, R | 1 |
| Kraemer, MJ | 1 |
| Furukawa, CT | 1 |
| Koup, JR | 1 |
| Shapiro, GG | 1 |
| Pierson, WE | 1 |
| Bierman, CW | 1 |
| Marquis, JF | 1 |
| Carruthers, SG | 1 |
| Spence, JD | 1 |
| Brownstone, YS | 1 |
| Toogood, JH | 1 |
| Erjefält, I | 1 |
| Burkle, WS | 1 |
| Gwizdala, CJ | 1 |
| Simons, FE | 1 |
| Friesen, FR | 1 |
| Simons, KJ | 1 |
| Gal, P | 1 |
| Roop, C | 1 |
| Robinson, H | 1 |
| Erkan, NV | 1 |
| Chu, NS | 1 |
| Franson, KL | 1 |
| Hay, DP | 1 |
| Neppe, V | 1 |
| Dahdal, WY | 1 |
| Mirza, WU | 1 |
| Grossberg, GT | 1 |
| Chatel, DM | 1 |
| Szwabo, PA | 1 |
| Kotegal, S | 1 |
| Shannon, M | 4 |
| Maher, T | 1 |
| Hoffman, A | 10 |
| Afargan, M | 2 |
| Pinto, E | 5 |
| Gilhar, D | 3 |
| Backon, J | 1 |
| Hornfeldt, CS | 1 |
| Larson, AA | 1 |
| Schattner, A | 1 |
| Alfon, J | 1 |
| Habib, G | 2 |
| Gorodetsky, R | 1 |
| Zhi, J | 1 |
| Nightingale, CH | 1 |
| Kulkarni, C | 2 |
| David, J | 2 |
| Joseph, T | 2 |
| Kearney, TE | 1 |
| Dyer, JE | 1 |
| Blanc, PD | 1 |
| O'Riordan, JI | 1 |
| Hutchinson, J | 1 |
| FitzGerald, MX | 2 |
| Hutchinson, M | 1 |
| Borowicz, K | 1 |
| Kozicka, M | 1 |
| Kleinrok, Z | 3 |
| Czuczwar, SJ | 3 |
| Powell, EC | 1 |
| Reynolds, SL | 1 |
| Rubenstein, JS | 1 |
| Levy, G | 17 |
| Zhang, G | 2 |
| Franklin, PH | 2 |
| Murray, TF | 4 |
| Blasco Navalpotro, MA | 1 |
| Zaragoza Crespo, R | 1 |
| Corrales Rodríguez de Tembleque, M | 1 |
| Rábago Sociats, R | 1 |
| Glenn, GM | 1 |
| Krober, MS | 1 |
| Kelly, P | 1 |
| McCarty, J | 1 |
| Weir, M | 1 |
| Jira, PE | 1 |
| Semmekrot, BA | 1 |
| Vree, TB | 1 |
| Monnens, LA | 1 |
| Yamamoto, K | 1 |
| Toyama, E | 1 |
| Kawakami, J | 1 |
| Sawada, Y | 1 |
| Iga, T | 1 |
| Urbańska, EM | 1 |
| Drelewska, E | 1 |
| Borowicz, KK | 1 |
| Błaszczak, P | 1 |
| Barr, DS | 1 |
| Hoyt, KL | 1 |
| Moore, SD | 1 |
| Wilson, WA | 1 |
| Yokoyama, H | 1 |
| Onodera, K | 1 |
| Yagi, T | 1 |
| Iinuma, K | 1 |
| Chakrabarti, A | 1 |
| Saini, HK | 1 |
| Garg, SK | 1 |
| Levasseur, LM | 1 |
| Delon, A | 1 |
| Greco, WR | 1 |
| Faury, P | 1 |
| Bouquet, S | 2 |
| Delanty, N | 1 |
| Vaughan, CJ | 1 |
| French, JA | 1 |
| Fink, M | 1 |
| Sackeim, HA | 1 |
| Amabeoku, GJ | 1 |
| Sanae, F | 1 |
| Hayashi, H | 1 |
| Chisaki, K | 1 |
| Komatsu, Y | 1 |
| Bonner, AB | 1 |
| Peterson, SL | 1 |
| Weir, MR | 1 |
| Maegaki, Y | 1 |
| Hahn, IH | 1 |
| Varney, S | 1 |
| Perlstein, I | 1 |
| Tchekalarova, J | 1 |
| Kambourova, T | 1 |
| Georgiev, V | 3 |
| Miura, T | 1 |
| Kimura, K | 1 |
| Seto, T | 1 |
| Inada, H | 1 |
| Kobayashi, N | 1 |
| Tada, H | 1 |
| Furukawa, K | 1 |
| Hayashi, K | 1 |
| Hattori, H | 1 |
| Matsuoka, O | 1 |
| Isshiki, G | 1 |
| Vanpee, D | 1 |
| Dive, A | 1 |
| Ossemann, M | 1 |
| Gillet, JB | 1 |
| Sugimoto, T | 1 |
| Sugimoto, M | 1 |
| Uchida, I | 1 |
| Mashimo, T | 1 |
| Okada, S | 1 |
| Kockler, DR | 1 |
| McCarthy, MW | 1 |
| Lawson, CL | 1 |
| Cadart, M | 1 |
| Pariat, C | 1 |
| Chaudhary, G | 1 |
| Zwillich, CW | 1 |
| Sutton, FD | 1 |
| Neff, TA | 1 |
| Cohn, WM | 1 |
| Matthay, RA | 1 |
| Weinberger, MM | 1 |
| Van Dellen, RG | 2 |
| Lawyer, C | 1 |
| Aitchison, J | 1 |
| Sutton, J | 1 |
| Bennett, W | 1 |
| Wolff, ED | 1 |
| Driessen, OM | 1 |
| Markovska, V | 1 |
| Markovska, VL | 1 |
| Georgiev, VP | 1 |
| Cutrufo, C | 1 |
| Bortot, L | 1 |
| Giachetti, A | 1 |
| Manzini, S | 1 |
| Saitoh, Y | 1 |
| Bando, T | 1 |
| Kanamori, K | 1 |
| Mifune, J | 1 |
| Sasaki, F | 1 |
| Ishizaki, T | 1 |
| Miyabo, S | 1 |
| Grasela, TH | 1 |
| Dreis, MW | 1 |
| Vancutsem, PM | 1 |
| Schwark, WS | 1 |
| Hendeles, L | 2 |
| Wlaź, P | 1 |
| Roliński, Z | 1 |
| Williams, KG | 1 |
| Nicholson, JP | 1 |
| Basile, SA | 1 |
| Cury, JD | 1 |
| Scheller, JM | 1 |
| Henderson, A | 1 |
| Wright, DM | 1 |
| Mori, H | 1 |
| Mizutani, T | 1 |
| Yoshimura, M | 1 |
| Yamanouchi, H | 1 |
| Shimada, H | 1 |
| O'Mahony, MS | 1 |
| Morimoto, K | 1 |
| Nii, Y | 1 |
| Hayakawa, T | 1 |
| Hada, J | 1 |
| Shimada, N | 1 |
| Hayashi, Y | 1 |
| Bahls, FH | 1 |
| Ma, KK | 1 |
| Bird, TD | 1 |
| Petersen, EN | 1 |
| Semel, JD | 1 |
| Allen, N | 1 |
| Bigler, ED | 1 |
| Zhi, JG | 4 |
| Thorat, SN | 1 |
| Kulkarni, SK | 1 |
| Ramzan, I | 4 |
| Sekizawa, K | 1 |
| Aikawa, T | 1 |
| Yanai, M | 1 |
| Itabashi, S | 1 |
| Fukushima, T | 1 |
| Sasaki, H | 1 |
| Christ, W | 1 |
| Sessler, CN | 1 |
| Dragunow, M | 1 |
| Whitcomb, K | 1 |
| Lupica, CR | 1 |
| Rosen, JB | 1 |
| Berman, RF | 1 |
| Klicpera, JA | 1 |
| Pinard, E | 1 |
| Riche, D | 1 |
| Puiroud, S | 1 |
| Seylaz, J | 1 |
| Emerman, CL | 1 |
| Devlin, C | 1 |
| Connors, AF | 1 |
| Karki, SD | 1 |
| Bentley, DW | 1 |
| Raghavan, M | 1 |
| Paciorek, PM | 1 |
| Cowlrick, IS | 1 |
| Perkins, RS | 1 |
| Taylor, JC | 1 |
| Wilkinson, GF | 1 |
| Waterfall, JF | 1 |
| Sato, S | 1 |
| Andersen, KH | 1 |
| Perry, PJ | 1 |
| Sherman, AD | 1 |
| Kathol, RG | 1 |
| Zhi, JQ | 1 |
| García Panhón, E | 1 |
| Jolis, R | 1 |
| Rodríguez Froján, G | 1 |
| Hernández Flix, S | 1 |
| Sanders, RC | 1 |
| Morgan, PF | 1 |
| Deckert, J | 1 |
| Jacobson, KA | 1 |
| Marangos, PJ | 2 |
| Daly, JW | 1 |
| Schneider, SM | 2 |
| Borok, Z | 2 |
| Michelson, EA | 1 |
| Eldridge, FL | 1 |
| Paydarfar, D | 1 |
| Scott, SC | 1 |
| Dowell, RT | 1 |
| DeDonato, V | 2 |
| Perrotin, D | 1 |
| Lebret, P | 1 |
| Furet, Y | 1 |
| Ged, E | 1 |
| Ginies, G | 1 |
| Andersson, KE | 1 |
| Kjellin, G | 1 |
| Sylvester, D | 1 |
| Schultz, CS | 1 |
| Szot, P | 1 |
| Marks, MB | 1 |
| Yasuhara, M | 5 |
| Blake, KV | 1 |
| Massey, KL | 1 |
| Nickerson, D | 1 |
| Neims, A | 1 |
| Fraley, DS | 1 |
| Adler, S | 1 |
| Kretz, M | 1 |
| Fischbach, M | 1 |
| Simeoni, U | 1 |
| Farge, A | 1 |
| Burtscher, A | 1 |
| Geisert, J | 1 |
| Juif, JG | 1 |
| Paloucek, FP | 1 |
| Rodvold, KA | 1 |
| Ramzan, IM | 4 |
| Napal, J | 1 |
| Echevarría, S | 1 |
| Riancho, JA | 1 |
| Macías, JG | 1 |
| Miller, G | 1 |
| Baker, MD | 1 |
| McCulloch, K | 1 |
| Vidyasagar, D | 1 |
| Yazdani, M | 1 |
| Kissling, GE | 1 |
| Tran, TH | 1 |
| Gottschalk, SK | 1 |
| Schuth, CR | 1 |
| Aitken, ML | 1 |
| Martin, TR | 1 |
| Bertino, JS | 1 |
| Walker, JW | 1 |
| Curtis, RA | 1 |
| Hutchinson, RA | 1 |
| Bederka, J | 1 |
| Troyer, WG | 1 |
| Clancy, RR | 1 |
| Kaplan, KM | 1 |
| Baumgart, S | 1 |
| Rosenberry, KR | 1 |
| Richards, W | 1 |
| Church, JA | 1 |
| Brent, DK | 1 |
| Covelli, HD | 1 |
| Knodel, AR | 1 |
| Heppner, BT | 1 |
| Noetzel, MJ | 1 |
| Auritt, WA | 1 |
| McGeady, SJ | 1 |
| Mansmann, HC | 1 |
| Weiss, SR | 1 |
| Post, RM | 1 |
| Patel, J | 1 |
| Rietveld, AP | 1 |
| Diderich, PP | 1 |
| Herman, ZS | 1 |
| Sattin, A | 1 |
| Roussinov, KS | 1 |
| Lazarova, MB | 1 |
| Atanassova-Shopova, S | 1 |
| Sternberg, B | 1 |
| Lerique-Koechlin, A | 1 |
| Mises, J | 1 |
| Dietz, AJ | 1 |
| Burgison, RM | 1 |
15 reviews available for theophylline and Seizures
| Article | Year |
|---|---|
[Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect].
Topics: Animals; Diphenhydramine; Drug Discovery; Drug Evaluation, Preclinical; Drug-Related Side Effects an | 2018 |
Fenethylline (Captagon) Abuse - Local Problems from an Old Drug Become Universal.
Topics: Amphetamines; Central Nervous System Stimulants; Humans; Middle East; Seizures; Substance-Related Di | 2016 |
Common causes of uncommon seizures.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antiviral Agents; Asthma; Brain; Bronchiolitis; Child; | 2009 |
Seizures associated with levofloxacin: case presentation and literature review.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteremia; Cytochrome | 2009 |
Methylxanthines, seizures, and excitotoxicity.
Topics: Adenosine; Animals; Caffeine; Humans; Neurotoxins; Seizures; Theophylline; Xanthines | 2011 |
First-line therapy for theophylline-associated seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Interactions; Female; Humans; Infant; Male; Pyrones; | 2007 |
Aminophylline.
Topics: Adult; Aminophylline; Anesthesia; Animals; Anticonvulsants; Arrhythmias, Cardiac; Asthma; Biotransfo | 1981 |
Drug-induced seizures in the elderly. Causative agents and optimal management.
Topics: Aging; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsants; Antidepressive Agents; Antipsy | 1995 |
Medical causes of seizures.
Topics: Acute Kidney Injury; Anticonvulsants; Antitubercular Agents; Blood Pressure; Brain Diseases; Broncho | 1998 |
[Adverse-effects of theophylline on the central nervous system; clinical characteristics of theophylline-associated seizures].
Topics: Bronchodilator Agents; Cerebrovascular Circulation; Humans; Prognosis; Purinergic P1 Receptor Antago | 1999 |
Clinical pharmacology. Series on pharmacology in practice. 4. Theophylline. Practical application of new knowledge.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aminophylline; Bronchi; Child; Child, Preschool; Dela | 1979 |
Theophylline toxicity: clinical features of 116 consecutive cases.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Charcoal; Chromatography, High Pressure Liquid; Drug Overdo | 1990 |
Effects of enprofylline and theophylline may show the role of adenosine.
Topics: Adenosine; Animals; Asthma; Brain; Bronchodilator Agents; Caffeine; Diuresis; Fatty Acids, Nonesteri | 1986 |
Theophylline: primary or tertiary drug? A brief review.
Topics: Asthma; Child, Preschool; Cromolyn Sodium; Humans; Seizures; Theophylline | 1987 |
Evaluation of theophylline overdoses and toxicities.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Charcoal; Child; Child, Preschool; Female; Hemoperfusion | 1988 |
198 other studies available for theophylline and Seizures
| Article | Year |
|---|---|
Oral theophylline augmentation for patients with missed or inadequate seizures with electroconvulsive therapy.
Topics: Aged; Electroconvulsive Therapy; Female; Humans; Male; Middle Aged; Retrospective Studies; Seizures; | 2022 |
Effectiveness Oral Theophylline, Piracetam, and Iron Treatments in Children With Simple Breath-Holding Spells.
Topics: Breath Holding; Child, Preschool; Female; Humans; Iron; Male; Piracetam; Retrospective Studies; Seiz | 2020 |
Severe pallid breath-holding spells treated with low-dose theophylline.
Topics: Apnea; Breath Holding; Dose-Response Relationship, Drug; Heart Arrest; Humans; Infant; Male; Seizure | 2021 |
[Nonconvulsive Status Epilepticus Associated with Theophylline: A Case Report].
Topics: Aged, 80 and over; Cerebral Infarction; Female; Hemiplegia; Humans; Seizures; Status Epilepticus; Th | 2021 |
Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy.
Topics: Anesthetics, Intravenous; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroconvul | 2017 |
Glycopyrrolate and theophylline for the treatment of severe pallid breath-holding spells.
Topics: Apnea; Breath Holding; Female; Glycopyrrolate; Humans; Infant; Muscarinic Antagonists; Phosphodieste | 2013 |
Methylxanthines do not affect rhythmogenic preBötC inspiratory network activity but impair bursting of preBötC-driven motoneurons.
Topics: Animals; Caffeine; Inhalation; Interneurons; Motor Neurons; Neural Pathways; Organ Culture Technique | 2013 |
Impact of an oral theophylline loading dose pre-electroconvulsive therapy: a retrospective study in patients with missed or inadequate seizures.
Topics: Adult; Electroconvulsive Therapy; Electroencephalography; Female; Humans; Male; Middle Aged; Puriner | 2015 |
The role of alpha-2 adrenoceptors in the anticonvulsant effects of adenosine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic | 2014 |
Methylxanthine-evoked perturbation of spontaneous and evoked activities in isolated newborn rat hippocampal networks.
Topics: Animals; Animals, Newborn; CA3 Region, Hippocampal; Caffeine; Calcium; Nerve Net; Pyramidal Cells; R | 2015 |
Case Report: The risks associated with chronic theophylline therapy and measures designed to improve monitoring and management.
Topics: Bronchodilator Agents; Combined Modality Therapy; Delayed Diagnosis; Drug Interactions; Drug Monitor | 2016 |
Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds.
Topics: Animals; CA1 Region, Hippocampal; Diphenhydramine; Enoxacin; In Vitro Techniques; Male; Mice; Mice, | 2017 |
Severe theophylline poisoning treated with continuous venovenous hemodialysis in a child.
Topics: Bronchodilator Agents; Child, Preschool; Female; Humans; Intensive Care Units, Pediatric; Renal Dial | 2016 |
[Clinical review of patients with seizures that developed during theophylline administration--(III) Safety of theophylline examined in patients who had sequelae or died].
Topics: Age Factors; Child; Child, Preschool; Communicable Diseases; Drug-Related Side Effects and Adverse R | 2008 |
Antiepileptic potential and behavioral profile of L-pGlu-(2-propyl)-L-His-L-ProNH2, a newer thyrotropin-releasing hormone analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Blood Pressure; Cardiovascular System; Central Nervous S | 2009 |
Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.
Topics: Adenosine; Adenosine Kinase; Animals; Animals, Newborn; Astrocytes; Electric Stimulation; Enzyme Inh | 2009 |
Adenosine A1 receptor blockage mediates theophylline-associated seizures.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Anim | 2010 |
Theophylline-induced changes in mouse electroencephalograms.
Topics: Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Electroencephalography; Male; Mice | 2010 |
[A case of theophylline-associated seizures with postictal fever and postictal pleocytosis].
Topics: Aged; Bronchodilator Agents; Fever; Humans; Leukocytosis; Male; Seizures; Theophylline | 2010 |
Effect of heat exposure on aminophylline-induced convulsions in mice.
Topics: Aminophylline; Animals; Dizocilpine Maleate; Fever; Male; Mice; Muscimol; Seizures; Theophylline | 2011 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; | 2012 |
Synthesis and preliminary pharmacological screening of novel imidazo[2,1-f]theophylline derivatives.
Topics: Amphetamine; Animals; Apomorphine; Central Nervous System Stimulants; Dopamine Agonists; Drug Antago | 2002 |
Adenosine receptors do not mediate the melatonin protection against pentylenetetrazole induced seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Male; Melatonin; Pentylenetetrazole; Purinergic P1 Receptor Ant | 2001 |
[Cutaneous changes and prevention of convulsions under vitamin D2 hypervitaminosis in albino rats].
Topics: Administration, Cutaneous; Animals; Cholestanes; Ergocalciferols; Rats; Seizures; Skin; Theophylline | 1953 |
A comparison of the relative toxic, emetic and convulsive actions of a series of methylated xanthine derivatives.
Topics: Emetics; Poisoning; Seizures; Theophylline; Vomiting; Xanthine; Xanthines | 1956 |
[Intoxication by rectal theophylline in the young infant. Apropos of a case].
Topics: Child; Humans; Infant; Seizures; Theophylline | 1960 |
[POTENTIATION BY THEOPHYLLINE AND CAFFEINE OF THE CONVULSANT EFFECTS AND TOXICITY OF ISONIAZID].
Topics: Caffeine; Convulsants; Isoniazid; Pharmacology; Rats; Research; Seizures; Theophylline; Toxicology | 1964 |
TOXICITY AND CONVULSIVE ACTIVITY OF A SERIES OF THEOPHYLLINE DERIVATIVES.
Topics: Aminophylline; Animals; Cats; Cricetinae; Dogs; Haplorhini; Mice; Pharmacology; Rats; Research; Seiz | 1965 |
[On the treatment of "apoplectic attacks" with apoplectal].
Topics: Aesculus; Fagaceae; Seizures; Stroke; Theophylline | 1960 |
Extension of the isobolographic approach to interactions studies between more than two drugs: illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats.
Topics: Animals; Drug Interactions; Male; Norfloxacin; Pefloxacin; Rats; Rats, Sprague-Dawley; Seizures; The | 2004 |
The effects of DFP on the convulsant dose of theophylline, theophylline-ethylenediamine and 8-chlorotheophylline.
Topics: Aminophylline; Convulsants; Humans; Isoflurophate; Organophosphonates; Phosphorous Acids; Seizures; | 1951 |
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner.
Topics: Adenosine; Animals; Animals, Newborn; Dihydropyridines; Dose-Response Relationship, Drug; Drug Inter | 2004 |
Suppression of generalized seizures activity by intrathalamic 2-chloroadenosine application.
Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Electroencephalography; Male; Pentylenetetrazole; Purin | 2005 |
Changes in neuromodulatory effect of adenosine A1 receptors on piriform cortex field potentials in amygdala kindled rats.
Topics: Adenosine; Amygdala; Animals; Excitatory Postsynaptic Potentials; Kindling, Neurologic; Male; Olfact | 2007 |
Free radicals and theophylline neurotoxicity : an experimental study.
Topics: alpha-Tocopherol; Aminophylline; Animals; Antioxidants; Arginine; Ascorbic Acid; Dose-Response Relat | 2007 |
[A clinical review of patients with convulsions during theophylline administration II: points to consider in administration and prognosis as determined in patients with theophyline toxicosis].
Topics: Asthma; Bronchodilator Agents; Child; Child, Preschool; Female; Humans; Infant; Male; Prognosis; Sei | 2007 |
First-line therapy for theophylline-associated seizures.
Topics: Age of Onset; Animals; Anticonvulsants; Barbiturates; Brain Damage, Chronic; Child; Child, Preschool | 2007 |
Theophylline-associated seizures and their clinical characterizations.
Topics: Bronchodilator Agents; Child; Child, Preschool; Electroencephalography; Female; Humans; Infant; Magn | 2008 |
[Case of an 81-year-old woman with theophylline-associated seizures followed by partial seizures due to vitamin B6 deficiency].
Topics: Aged, 80 and over; Bronchodilator Agents; Epilepsies, Partial; Female; Humans; Seizures; Theophyllin | 2008 |
[Treatment for seizures during theophylline medication].
Topics: Anticonvulsants; Barbiturates; Bronchodilator Agents; Child, Preschool; Diazepam; Drug Resistance; H | 2008 |
Is theophylline-induced seizures in man caused by inhibition of cerebral 5'-nucleotidase activity?
Topics: Adenosine Triphosphate; Brain; Energy Metabolism; Humans; Nucleotidases; Purines; Seizures; Theophyl | 1984 |
Cimetidine-theophylline interaction: report of four patients.
Topics: Adrenergic beta-Agonists; Aged; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Lung Dise | 1982 |
Homocysteine-induced seizures in the mouse cerebral cortex after propranolol pretreatment. Lack of correlation between cyclic adenosine monophosphate levels and phosphorylase activation.
Topics: Animals; Cerebral Cortex; Cyclic AMP; Homocysteine; Male; Mice; Mice, Inbred Strains; Phosphorylases | 1981 |
Universal adenosine receptor antagonism is neither necessary nor desirable with xanthine antiasthmatics.
Topics: Adenosine; Airway Resistance; Animals; Asthma; Central Nervous System; Diuresis; Dose-Response Relat | 1982 |
Interactions of the anticonvulsant carbamazepine with adenosine receptors. 2. Pharmacological studies.
Topics: Animals; Carbamazepine; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Nicotine; Purines; Rec | 1983 |
Metabolic abnormalities associated with intentional theophylline overdose.
Topics: Acid-Base Imbalance; Adolescent; Adult; Female; Humans; Hyperglycemia; Hypokalemia; Insulin; Leukocy | 1984 |
Benefit of hemoperfusion in acute theophylline intoxication.
Topics: Adolescent; Adult; Aged; Blood Pressure; Charcoal; Female; Heart Rate; Hemoperfusion; Humans; Male; | 1984 |
Interaction of theophylline with erythromycin base in a patient with seizure activity.
Topics: Asthma; Bronchitis; Child; Drug Interactions; Erythromycin; Female; Half-Life; Humans; Metabolic Cle | 1983 |
Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents, and charcoal hemoperfusion.
Topics: Aged; Heart Rate; Hemoperfusion; Humans; Hypotension; Kinetics; Male; Middle Aged; Propranolol; Seiz | 1984 |
Theophylline poisoning.
Topics: Charcoal; Hemoperfusion; Humans; Seizures; Theophylline | 1984 |
Acute pediatric theophylline overdose: a summary of 28 cases.
Topics: Acute Disease; Adolescent; Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Female; Humans; Inf | 1983 |
Hemoperfusion in theophylline neurotoxicity.
Topics: Age Factors; Central Nervous System Diseases; Child, Preschool; Female; Hemoperfusion; Humans; Infan | 1983 |
Theophylline-induced seizures: clinical and pathophysiologic aspects.
Topics: Aged; Female; Humans; Male; Seizures; Theophylline | 1983 |
Use of hemoperfusion for treatment of theophylline intoxication.
Topics: Adolescent; Adult; Aged; Blood; Charcoal; Child; Child, Preschool; Half-Life; Humans; Infant; Middle | 1983 |
Massive accidental theophylline ingestion: linear first order elimination kinetics in an infant.
Topics: Dose-Response Relationship, Drug; Female; Humans; Hyperglycemia; Infant; Kinetics; Pneumonia, Aspira | 1982 |
Altered theophylline clearance during an influenza B outbreak.
Topics: Asthma; Child; Disease Outbreaks; Headache; Humans; Influenza, Human; Male; Metabolic Clearance Rate | 1982 |
Phenytoin-theophylline interaction.
Topics: Asthma; Drug Interactions; Half-Life; Humans; Male; Middle Aged; Phenytoin; Seizures; Theophylline | 1982 |
Risks of theophylline therapy in asthma.
Topics: Asthma; Child; Humans; Risk; Seizures; Theophylline | 1981 |
Convulsive effect of theophylline in conscious and anaesthetized guinea-pigs.
Topics: Administration, Oral; Anesthesia, General; Animals; Blood Pressure; Dose-Response Relationship, Drug | 1981 |
Evaluation of "toxic" serum theophylline concentrations.
Topics: Heart Failure; Humans; Seizures; Theophylline | 1981 |
Theophylline toxicity in term infants.
Topics: Bronchopneumonia; Half-Life; Humans; Infant; Infant, Newborn; Infant, Premature; Injections, Intrave | 1980 |
I.V. dosage guidelines for theophylline products.
Topics: Humans; Injections, Intravenous; Seizures; Theophylline | 1980 |
Theophylline-induced seizures in accidentally overdosed neonates.
Topics: Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Seizures; Theophylline | 1980 |
Caffeine- and aminophylline-induced seizures.
Topics: Aminophylline; Animals; Arrhythmias, Cardiac; Caffeine; Cerebral Cortex; Electrocardiography; Electr | 1981 |
Anticonvulsant effects of intracerebroventricular adenocard in theophylline-induced seizures.
Topics: Adenosine; Aminophylline; Animals; Cerebral Ventricles; Male; Rats; Rats, Sprague-Dawley; Seizures; | 1995 |
Differential effects of various antiinflammatory drugs on theophylline neurotoxicity.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; | 1994 |
Adenosine receptors are not involved in theophylline-induced seizures.
Topics: Adenosine; Animals; Carbamazepine; Dipyridamole; Dose-Response Relationship, Drug; Injections, Intra | 1994 |
Cyclosporine enhances theophylline neurotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Proteins; Blood Urea Nitrogen; Chr | 1994 |
The effect of immunosuppression by total-body irradiation on the pharmacodynamics of centrally active drugs in rats.
Topics: Animals; Brain; Central Nervous System Agents; Central Nervous System Depressants; Ethanol; Female; | 1994 |
Biphenylacetate, but not theophylline, lethally interacts with ciprofloxacin in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ciprofloxacin; Drug Interactions; Female; Mice; Ph | 1993 |
Involvement of adenosine in postictal events in rats given electroshock.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Electroshock; Female; Hindlimb | 1994 |
Seizures associated with poisoning and drug overdose.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Caus | 1993 |
Amnesic syndrome after theophylline associated seizures: iatrogenic brain injury.
Topics: Adolescent; Aged; Amnesia; Brain; Female; Humans; Magnetic Resonance Imaging; Male; Seizures; Syndro | 1994 |
Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; | 1993 |
Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat.
Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Ani | 1993 |
Chronopharmacodynamics of theophylline neurotoxicity in rats.
Topics: Animals; Brain; Chronobiology Phenomena; Male; Rats; Seizures; Theophylline | 1993 |
Theophylline toxicity in children: a retrospective review.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Male; Retrospective Studies; Seizures; | 1993 |
Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats.
Topics: Adrenalectomy; Animals; Blood Proteins; Corticosterone; Male; Pain; Pain Threshold; Phenobarbital; R | 1993 |
Manipulation of endogenous adenosine in the rat prepiriform cortex modulates seizure susceptibility.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Kinase; Animals; Bicucul | 1993 |
[Theophylline-induced convulsions].
Topics: Aged; Humans; Lung Diseases, Obstructive; Male; Poisoning; Seizures; Theophylline | 1993 |
Pyridoxine as therapy in theophylline-induced seizures.
Topics: Aminophylline; Animals; Bronchodilator Agents; Disease Models, Animal; Electroencephalography; Femal | 1995 |
[Theophylline poisoning in children].
Topics: Akathisia, Drug-Induced; Female; Humans; Infant, Newborn; Medication Errors; Peritoneal Dialysis; Po | 1996 |
Neurotoxic convulsions induced by theophylline and its metabolites in mice.
Topics: Animals; Blood-Brain Barrier; Brain; Infusions, Intravenous; Injections, Intraventricular; Male; Mic | 1996 |
NG-nitro-L-arginine, a nitric oxide synthase inhibitor, and seizure susceptibility in four seizure models in mice.
Topics: Aminooxyacetic Acid; Aminophylline; Animals; Convulsants; Drug Synergism; Electroshock; Enzyme Inhib | 1996 |
Post-ictal depression transiently inhibits induction of LTP in area CA1 of the rat hippocampal slice.
Topics: Animals; Electric Stimulation; Electroshock; Hippocampus; In Vitro Techniques; Long-Term Potentiatio | 1997 |
Influence of adenosine, dipyridamole, adenosine antagonists and antiepileptic drugs on EEG after discharge following cortical stimulation.
Topics: Adenosine; Aminophylline; Animals; Anticonvulsants; Cerebral Cortex; Dipyridamole; Electric Stimulat | 1997 |
Therapeutic doses of theophylline exert proconvulsant effects in developing mice.
Topics: Aging; Animals; Anticonvulsants; Bronchodilator Agents; Dose-Response Relationship, Drug; Electrosho | 1997 |
A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats.
Topics: Aminophylline; Animals; Bronchodilator Agents; Convulsants; Disease Models, Animal; Drug Interaction | 1997 |
Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats.
Topics: Animals; Anti-Infective Agents; Drug Interactions; Male; Mathematical Computing; Models, Biological; | 1998 |
Theophylline and ECT.
Topics: Adult; Aged; Electroconvulsive Therapy; Electroencephalography; Female; Humans; Risk Assessment; Sei | 1998 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cl | 1999 |
Effects of Saiko-ka-ryukotsu-borei-to, a Japanese Kampo medicine, on tachycardia and central nervous system stimulation induced by theophylline in rats and mice.
Topics: Anesthesia; Animals; Atrial Function, Right; Blood Pressure; Cardiotonic Agents; Central Nervous Sys | 1999 |
Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Interactions; Male; Pentylenetetrazole; Protec | 1997 |
Life-threatening events after theophylline overdose: a 10-year prospective analysis.
Topics: Acute Disease; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Bronchodilator Agents; Chronic Disease | 1999 |
Effect of adenosinergic modulation on the anticonvulsant effect of phenobarbitone and carbamazepine.
Topics: Adenosine; Animals; Anticonvulsants; Carbamazepine; Convulsants; Drug Combinations; Male; Pentylenet | 1999 |
Seizures induced by theophylline and isoniazid in mice.
Topics: Animals; Antitubercular Agents; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Iso | 1999 |
Pyridoxine treatment for seizures induced by theophylline and isoniazid?
Topics: Animals; Drug Interactions; Isoniazid; Mice; Pyridoxine; Seizures; Theophylline | 1999 |
The effect of cimetidine on the pharmacodynamics of theophylline-induced seizures and ethanol hypnotic activity.
Topics: Animals; Anti-Ulcer Agents; Brain; Cimetidine; Drug Interactions; Ethanol; Female; Hypnosis; Posture | 1999 |
Long-term theophylline treatment changes the effects of angiotensin II and adenosinergic agents on the seizure threshold.
Topics: Adenosine; Angiotensin II; Animals; Convulsants; Differential Threshold; Male; Mice; Mice, Inbred IC | 2000 |
Theophylline-induced convulsions in children with epilepsy.
Topics: Asthma; Bronchodilator Agents; Child; Epilepsy; Humans; Infant; Retrospective Studies; Seizures; The | 2000 |
Influence of adenosine agonists and antiepileptic drugs on theophylline-induced seizures in rats.
Topics: Adenosine; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Male; Phosphodiesterase Inhibitors; Pur | 1998 |
[Depression of serum pyridoxal levels in theophylline-related seizures].
Topics: Adolescent; Adult; Asthma; Biomarkers; Child; Child, Preschool; Humans; Male; Pyridoxal; Seizures; T | 2000 |
Refractory seizure with hypokalaemia.
Topics: Aged; Bronchodilator Agents; Diagnosis, Differential; Drug Overdose; Female; Humans; Hypokalemia; Me | 2001 |
Inhibitory effect of theophylline on recombinant GABA(A) receptor.
Topics: Animals; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gene Expression; Ion Cha | 2001 |
Seizure activity and unresponsiveness after hydroxycut ingestion.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Citrates; Drug Combinations; Drugs, Chinese Herb | 2001 |
Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin-theophylline convulsant interaction in rats.
Topics: Algorithms; Animals; Anti-Infective Agents; Bronchodilator Agents; Chromatography, High Pressure Liq | 2002 |
Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system.
Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2002 |
Changes of cyclic AMP and phosphorylase a in mouse cerebral cortex during seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Animals; Cerebral Cortex; Cyclic AMP; Male; Mice; Phenobarbital; Phosphory | 1977 |
Theophylline-induced seizures in adults. Correlation with serum concentrations.
Topics: Adult; Aged; Creatinine; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Hydrogen-Ion Co | 1975 |
Intravenous aminophylline.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aminophylline; Asthma; Body Weight; Child; Half-Life | 1979 |
Treatment of theophylline neurotoxicity with resin hemoperfusion.
Topics: Female; Hemoperfusion; Humans; Middle Aged; Resins, Plant; Seizures; Theophylline | 1978 |
[Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam].
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; gamma-Amino | 1978 |
A child with theophylline poisoning.
Topics: Asthma; Blood Circulation; Blood Transfusion; Brain Edema; Child, Preschool; Coma; Digoxin; Heart Ma | 1977 |
Effects of apomorphine, pimoside, theophylline, meta-tolylcarbamide and diazepam on the picrotoxin convulsive-seizure threshold.
Topics: Animals; Apomorphine; Brain; Diazepam; Male; Mice; Phenylurea Compounds; Picrotoxin; Pimozide; Seizu | 1976 |
Are the central dopaminergic synapses related to the convulsive-seizure threshold?--Effects of central dopaminergic drugs on the picrotoxin convulsive-seizure threshold. Interaction with diazepam, meta-tolylcarbamide and theophylline.
Topics: Animals; Apomorphine; Diazepam; Drug Interactions; Male; Mice; Phenylurea Compounds; Picrotoxin; Pim | 1976 |
Differential effects of various xanthines on pentylenetetrazole-induced seizures in rats: an EEG and behavioural study.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, | 1992 |
[Theophylline toxicity in a patient with status asthmaticus].
Topics: Aged; Female; Humans; Seizures; Status Asthmaticus; Theophylline | 1992 |
An evaluation of the quinolone-theophylline interaction using the Food and Drug Administration spontaneous reporting system.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anti-Bacterial Agents; Drug | 1992 |
Effects of fluoroquinolone antimicrobials alone and in conjunction with theophylline on seizures in amygdaloid kindled rats. Mechanistic and pharmacokinetic study.
Topics: 2-Chloroadenosine; Amygdala; Animals; Anti-Infective Agents; Chromatography, High Pressure Liquid; D | 1992 |
Theophylline and seizures.
Topics: Aged; Humans; Osmolar Concentration; Seizures; Serum Albumin; Theophylline | 1992 |
Anticonvulsant activity of carbamazepine and diphenylhydantoin against maximal electroshock in mice chronically treated with aminophylline.
Topics: Aminophylline; Animals; Anticonvulsants; Carbamazepine; Electroshock; Male; Mice; Phenytoin; Seizure | 1992 |
Potential pharmacodynamic effect of charcoal on theophylline neurotoxicity in normal rats.
Topics: Animals; Brain; Charcoal; Male; Nervous System Diseases; Rats; Seizures; Theophylline | 1992 |
Pharmacists' duty to warn of drug interactions. Dooley v. Everett.
Topics: Child; Drug Interactions; Duty to Warn; Erythromycin; Humans; Liability, Legal; Male; Pharmacists; S | 1992 |
Massive theophylline dosing in a heavy smoker receiving both phenytoin and phenobarbital.
Topics: Adult; Asthma; Drug Administration Schedule; Female; Humans; Phenobarbital; Phenytoin; Seizures; Smo | 1992 |
Seizures during theophylline therapy.
Topics: Child; Female; Humans; Infant; Male; Seizures; Theophylline | 1992 |
Management of theophylline overdose patients in the intensive care unit.
Topics: Absorption; Adolescent; Adult; Arrhythmias, Cardiac; Charcoal; Critical Care; Drug Overdose; Female; | 1992 |
Unilateral brain damage after prolonged hemiconvulsions in the elderly associated with theophylline administration.
Topics: Aged; Brain; Brain Injuries; Epilepsy; Humans; Male; Nerve Degeneration; Seizures; Thalamus; Theophy | 1992 |
Effect of acute versus chronic intoxication on clinical features of theophylline poisoning in children.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Arrhythmias, Cardiac; Bicarbonates; Child; Child, Pre | 1992 |
Cystic fibrosis and seizures.
Topics: Adult; Ciprofloxacin; Cystic Fibrosis; Humans; Seizures; Theophylline | 1991 |
Effect of adenosine agonist (propentofylline) on rat hippocampal seizures induced by microdialysis with potassium: analysis using compressed EEG power spectrum array.
Topics: Adenosine; Animals; Electroencephalography; Evoked Potentials; Hippocampus; Male; Potassium; Rats; R | 1991 |
Theophylline-associated seizures with "therapeutic" or low toxic serum concentrations: risk factors for serious outcome in adults.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Nervous Syste | 1991 |
Selective protection by adenosine receptor agonists against DMCM-induced seizures.
Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Female | 1991 |
Seizures in patients simultaneously receiving theophylline and imipenem or ciprofloxacin or metronidazole.
Topics: Aged; Ciprofloxacin; Drug Interactions; Drug Therapy, Combination; Epilepsies, Partial; Female; Huma | 1991 |
Theophylline neurotoxicity resulting in diffuse brain damage.
Topics: Dose-Response Relationship, Drug; Humans; Hyaline Membrane Disease; Infant; Infant, Newborn; Male; M | 1991 |
Kinetics of drug action in disease states. XL. Effect of the dialyzable component(s) of uremic blood on theophylline neurotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Central Nervous System; Creatinine; Kidney; Male; Rats; Rats, Inbred L | 1991 |
Effect of orally administered dextromethorphan on theophylline- and pentylenetetrazol-induced seizures in rats.
Topics: Administration, Oral; Animals; Dextromethorphan; Female; Pentylenetetrazole; Premedication; Rats; Ra | 1990 |
Effect of MK-801 and its interaction with adenosinergic agents and carbamazepine against hypoxic stress-induced convulsions and death in mice.
Topics: 2-Chloroadenosine; Adenosine; Animals; Carbamazepine; Dipyridamole; Dizocilpine Maleate; Drug Intera | 1990 |
Theophylline neurotoxicity is unaffected by glycerol-induced renal failure.
Topics: Acute Kidney Injury; Animals; Glycerol; Male; Nervous System Diseases; Rats; Rats, Inbred Strains; S | 1990 |
Permanent brain damage possibly caused by theophylline in two elderly patients with airway obstruction.
Topics: Aged; Asthma; Brain Diseases; Female; Humans; Lung Diseases, Obstructive; Male; Seizures; Theophylli | 1990 |
Central nervous system toxicity of quinolones: human and animal findings.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Cip | 1990 |
Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline.
Topics: Adenosine; Aminophylline; Amygdala; Animals; Brain; Carbolines; Diazepam; Flumazenil; Kindling, Neur | 1990 |
The influence of age vs peak serum concentration on life-threatening events after chronic theophylline intoxication.
Topics: Age Factors; Arrhythmias, Cardiac; Boston; Chronic Disease; Humans; Longitudinal Studies; Middle Age | 1990 |
Adenosine involvement in postictal events in amygdala-kindled rats.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Amygdala; Animals; Anticonvulsants; Caffeine; Electric | 1990 |
Theophylline toxicity.
Topics: Humans; Seizures; Theophylline | 1990 |
Effect of chronic caffeine administration on theophylline concentrations required to produce seizures in rats.
Topics: Animals; Caffeine; Drug Interactions; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizur | 1990 |
Theophylline reduces cerebral hyperaemia and enhances brain damage induced by seizures.
Topics: Adenosine; Animals; Cerebrovascular Circulation; Kainic Acid; Male; Rats; Rats, Inbred Strains; Seiz | 1990 |
Risk of toxicity in patients with elevated theophylline levels.
Topics: Aged; Arrhythmias, Cardiac; Causality; Female; Heart Failure; Humans; Hypotension; Intensive Care Un | 1990 |
Seizure with ciprofloxacin and theophylline combined therapy.
Topics: Aged; Aged, 80 and over; Ciprofloxacin; Drug Therapy, Combination; Female; Humans; Male; Seizures; T | 1990 |
Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig.
Topics: Albuterol; Anesthesia; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Decerebrate State; D | 1990 |
Effect of ephedrine and hydrocortisone on theophylline-induced seizures in rats.
Topics: Animals; Drug Interactions; Ephedrine; Hydrocortisone; Infusions, Intravenous; Male; Rats; Rats, Inb | 1990 |
Anticonvulsant effect of N-ethylcarboxamidoadenosine against kainic acid-induced behavioral seizures in the rat prepiriform cortex.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dilazep; Kainic Acid; Limbic System; Male; Ra | 1990 |
Systemic effect of ipecac on acute toxicity of phenobarbital and theophylline in rats.
Topics: Animals; Cardiovascular Diseases; Ipecac; Male; Nervous System Diseases; Phenobarbital; Rats; Rats, | 1989 |
Behavioral performance and seizure activity of lithium-intoxicated Sprague-Dawley rats treated with theophylline.
Topics: 3-Mercaptopropionic Acid; Animals; Drug Interactions; Lithium; Male; Metabolic Clearance Rate; Motor | 1989 |
Kinetics of drug action in disease states. XXXVII. Effects of acute fluid overload and water deprivation on the hypnotic activity of phenobarbital and the neurotoxicity of theophylline in rats.
Topics: Animals; Dehydration; Glucose; Male; Phenobarbital; Rats; Rats, Inbred Lew; Seizures; Theophylline; | 1989 |
Aspartame and phenylalanine do not enhance theophylline-induced seizures in rats.
Topics: Animals; Aspartame; Body Temperature; Body Weight; Dipeptides; Drug Interactions; Female; Phenylalan | 1989 |
[Convulsions and multifocal auricular tachycardia induced by theophylline].
Topics: Aged; Aged, 80 and over; Female; Heart Atria; Humans; Seizures; Tachycardia; Theophylline | 1989 |
Proconvulsant effect of papaverine on theophylline-induced seizures in rats.
Topics: Animals; Behavior, Animal; Convulsants; Male; Papaverine; Rats; Rats, Inbred Strains; Seizures; Theo | 1989 |
Temporal relationship between A1 adenosine receptor upregulation and alterations in bicuculline seizure susceptibility in rats.
Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; | 1989 |
Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC).
Topics: Animals; Caffeine; Convulsants; Diazepam; Dipyridamole; Male; Mice; Purinergic Antagonists; Random A | 1989 |
Effect of enoxacin on theophylline neurotoxicity.
Topics: Animals; Body Temperature; Body Weight; Chromatography, High Pressure Liquid; Drug Interactions; Eno | 1989 |
Beta-blockade for acute theophylline-induced seizures.
Topics: Adrenergic beta-Antagonists; Animals; Blood Glucose; Male; Potassium; Propranolol; Rats; Rats, Inbre | 1987 |
Role of endogenous adenosine in recurrent generalized seizures.
Topics: Adenosine; Animals; Bicuculline; Blood Pressure; Cats; Cerebral Cortex; Dipyridamole; Doxapram; Nalo | 1989 |
Effect of nicotinamide on theophylline seizures in rats.
Topics: Animals; Male; Niacinamide; Rats; Rats, Inbred Strains; Seizures; Theophylline | 1988 |
[Onset of convulsive crises with theophylline therapy at therapeutic doses].
Topics: Aged; Blood Gas Analysis; Brain; Chronic Disease; Electroencephalography; Female; Humans; Male; Midd | 1988 |
Purinergic modulation of the seizure threshold for pentylenetetrazol in the rat.
Topics: 2-Chloroadenosine; Adenosine; Animals; Kinetics; Male; Pentylenetetrazole; Phenylisopropyladenosine; | 1985 |
Kinetics of drug action in disease states. XXVI: Effect of fever on the pharmacodynamics of theophylline-induced seizures in rats.
Topics: Animals; Blood Proteins; Fever; Male; Rats; Seizures; Theophylline | 1988 |
Relative efficacy of phenytoin and phenobarbital for the prevention of theophylline-induced seizures in mice.
Topics: Animals; Dose-Response Relationship, Drug; Lethal Dose 50; Male; Mice; Phenobarbital; Phenytoin; Sei | 1988 |
The effect of serum potassium on theophylline-induced seizures.
Topics: Animals; Male; Potassium; Rats; Rats, Inbred Strains; Seizures; Species Specificity; Theophylline | 1988 |
Kinetics of drug action in disease states XXVIII: Effect of acute hypovolemia on theophylline-induced neurotoxicity in rats.
Topics: Animals; Male; Nervous System Diseases; Rats; Rats, Inbred Strains; Seizures; Shock; Theophylline | 1988 |
Caffeine as a potential risk factor for theophylline neurotoxicity.
Topics: Animals; Blood Proteins; Brain; Caffeine; Dialysis; Injections, Intravenous; Male; Nervous System Di | 1988 |
[Severe theophylline poisoning in children. Value of hemodialysis with high permeability membrane].
Topics: Child, Preschool; Hemodialysis Solutions; Humans; Male; Membranes, Artificial; Renal Dialysis; Seizu | 1988 |
Rapid development of functional tolerance to caffeine-induced seizures in rats.
Topics: Animals; Brain; Caffeine; Drug Tolerance; Kinetics; Male; Rats; Rats, Inbred Lew; Seizures; Theobrom | 1988 |
Theophylline neurotoxicity in pregnant rats.
Topics: Animals; Female; Fetal Blood; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Seizures; Th | 1988 |
Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Rats; Rats, Inbred Le | 1986 |
Kinetics of drug action in disease states. XIX. Effect of experimental liver disease on the neurotoxicity of theophylline in rats.
Topics: Acute Kidney Injury; Animals; Carbon Tetrachloride Poisoning; Cholestasis, Extrahepatic; Female; Kin | 1987 |
[Convulsions induced by theophylline in adults. Presentation of 4 cases].
Topics: Aged; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Seizures; Theophylline | 1987 |
Chronic theophylline administration has no apparent effect on theophylline concentrations required to produce seizures in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Metabolic Cl | 1986 |
Phenobarbital improves survival in theophylline-intoxicated rabbits.
Topics: Animals; Injections, Intravenous; Phenobarbital; Phenytoin; Rabbits; Seizures; Theophylline | 1986 |
Theophylline toxicity in children.
Topics: Abdomen; Adolescent; Child; Child, Preschool; Female; Humans; Infant; Male; Pain; Seizures; Tachycar | 1986 |
Infantile apnea.
Topics: Apnea; Breast Feeding; Diagnosis, Differential; Gastroesophageal Reflux; Humans; Infant; Infant, New | 1986 |
Phenobarbital increases the theophylline requirement of premature infants being treated for apnea.
Topics: Apnea; Cerebral Hemorrhage; Drug Interactions; Humans; Infant, Newborn; Infant, Premature; Phenobarb | 1987 |
Life-threatening theophylline toxicity is not predictable by serum levels.
Topics: Aged; Arrhythmias, Cardiac; Female; Humans; Male; Medical Records; Middle Aged; Seizures; Theophylli | 1987 |
Kinetics of drug action in disease states. XVIII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats.
Topics: Animals; Brain; Disease Models, Animal; Female; Kidney Failure, Chronic; Protein Binding; Rats; Seiz | 1987 |
Reassessment of theophylline toxicity. Serum concentrations, clinical course, and treatment.
Topics: Aged; Arrhythmias, Cardiac; Blood Glucose; Charcoal; Humans; Leukocyte Count; Middle Aged; Potassium | 1987 |
Effect of empiric dosing on blood levels of theophylline and phenytoin.
Topics: Critical Care; Drug Administration Schedule; Humans; Immunoenzyme Techniques; Lung Diseases, Obstruc | 1985 |
Neonatal theophylline neurotoxicity.
Topics: Bronchopulmonary Dysplasia; Half-Life; Hepatitis; Humans; Infant; Infant, Newborn; Kinetics; Male; S | 1985 |
Theophylline-associated seizures in children.
Topics: Child; Erythromycin; Female; Humans; Male; Seizures; Theophylline | 1985 |
Predisposing factors to apparent theophylline-induced seizures.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Seizures; Theophylline | 1985 |
Theophylline neurotoxicity resulting in significant unilateral brain-damage.
Topics: Brain Damage, Chronic; Female; Hemiplegia; Humans; Infant; Seizures; Theophylline | 1985 |
The relationship of cerebrospinal fluid and plasma theophylline concentrations in children and adolescents taking theophylline.
Topics: Adolescent; Adult; Asthma; Blood-Brain Barrier; Child; Child, Preschool; Electroencephalography; Hum | 1985 |
Adenosine antagonists. Lack of effect on the inhibition of kindled seizures in rats by carbamazepine.
Topics: Adenosine; Animals; Caffeine; Carbamazepine; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains; | 1985 |
Theophylline overdose: acute single ingestion versus chronic repeated overmedication.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Chronic Disease; Delay | 1985 |
[A patient with severe theophylline poisoning].
Topics: Acidosis; Adult; Arrhythmias, Cardiac; Hemoperfusion; Humans; Male; Rhabdomyolysis; Seizures; Suicid | 1985 |
Behavioural effects of dibutyryl cyclic 3',5' AMP, noradrenaline and cyclic 3',5' AMP in rats.
Topics: Animals; Behavior, Animal; Cerebral Ventricles; Cyclic AMP; Dimethyl Sulfoxide; Drug Interactions; I | 1973 |
Increase in the content of adenosine 3',5'-monophosphate in mouse forebrain during seizures and prevention of the increase by methylxanthines.
Topics: Adenine Nucleotides; Caffeine; Central Nervous System Stimulants; Cyclic AMP; Electroshock; Ethers; | 1971 |
Experimental study of the effect of lithium, haloperidol, caffeine and theophylline on convulsive seizure reactions.
Topics: Animals; Caffeine; Drug Synergism; Haloperidol; Lithium; Male; Rats; Seizures; Theophylline | 1974 |
[The electroencephalogram in acute intoxications of children].
Topics: Age Factors; Alcoholic Intoxication; Aldehydes; Central Nervous System Diseases; Child; Child, Presc | 1969 |
The synthesis and pharmacologic evaluation of a series of 8-alkylthio-thiated theophyllines.
Topics: Animals; Central Nervous System; Chemistry, Organic; Diuresis; Heart Rate; Intestines; Male; Muscle, | 1966 |