theophylline has been researched along with Reperfusion Injury in 22 studies
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction." | 7.77 | Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. ( Aoyama, T; Bai, Y; Iwasa, M; Minatoguchi, S; Murakami, H; Nishigaki, K; Sumi, S; Takemura, G; Uno, B; Ushikoshi, H; Yamada, Y, 2011) |
| "Pretreatment with adenosine receptor antagonists, theophylline or 8-cyclopentyl-1,3-dipropyl xanthine (DPCPX) prior to ischemic preconditioning or adenosine preconditioning abolished the protective effects of preconditioning by ischemic preconditioning and adenosine preconditioning." | 5.34 | Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors. ( Demiryürek, AT; Gümüşel, B; Lippton, H; Yildiz, G, 2007) |
| " The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction." | 3.77 | Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. ( Aoyama, T; Bai, Y; Iwasa, M; Minatoguchi, S; Murakami, H; Nishigaki, K; Sumi, S; Takemura, G; Uno, B; Ushikoshi, H; Yamada, Y, 2011) |
| "To investigate the dose-related effects of theophylline in prevention of ischemia-reperfusion injury of the lung." | 3.72 | Dose-related effects of theophylline added to modified Euro-Collins solution used for hypothermic preservation of lung. ( Aykac-Toker, G; Bayrak, Y; Bostanci, K; Dilege, S; Senturk, M; Toker, A; Tugrul, M, 2003) |
| "We examined the effect of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (ibudilast), which has been clinically used for bronchial asthma and cerebrovascular disorders, on cell viability induced in a model of reperfusion injury." | 3.71 | Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model. ( Baba, A; Enomoto, R; Lee, E; Matsuda, T; Mori, K; Takuma, K, 2001) |
| " In 10-day-old rats, mucosal permeability to 51Cr EDTA was measured after subjecting the animals to 10-minute ischemia-reperfusion injury, 30 minutes of hypoxia (14% oxygen), cold stress (4 degree C for 4 minutes), and intraperitoneal indomethacin (0." | 3.68 | Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs. ( Langer, JC; Mumford, DA; Sohal, SS, 1993) |
| "Pretreatment with adenosine receptor antagonists, theophylline or 8-cyclopentyl-1,3-dipropyl xanthine (DPCPX) prior to ischemic preconditioning or adenosine preconditioning abolished the protective effects of preconditioning by ischemic preconditioning and adenosine preconditioning." | 1.34 | Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors. ( Demiryürek, AT; Gümüşel, B; Lippton, H; Yildiz, G, 2007) |
| "Brief ischemia was reported to protect various cells against injury induced by subsequent ischemia-reperfusion, and this phenomenon is known as ischemic preconditioning." | 1.32 | Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina. ( Ishii, K; Kuwagata, M; Nakahara, T; Saito, M; Sakamoto, K; Yonoki, Y, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 9 (40.91) | 29.6817 |
| 2010's | 5 (22.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozturk, SA | 1 |
| Ceylan, C | 1 |
| Serel, TA | 1 |
| Doluoglu, OG | 1 |
| Soyupek, AS | 1 |
| Guzel, A | 1 |
| Özorak, A | 1 |
| Uz, E | 1 |
| Savas, HB | 1 |
| Baspinar, S | 1 |
| Eldaif, SM | 1 |
| Deneve, JA | 1 |
| Wang, NP | 1 |
| Jiang, R | 1 |
| Mosunjac, M | 1 |
| Mutrie, CJ | 1 |
| Guyton, RA | 1 |
| Zhao, ZQ | 1 |
| Vinten-Johansen, J | 1 |
| Wever, KE | 1 |
| Warlé, MC | 1 |
| Wagener, FA | 1 |
| van der Hoorn, JW | 1 |
| Masereeuw, R | 1 |
| van der Vliet, JA | 1 |
| Rongen, GA | 1 |
| Bai, Y | 1 |
| Murakami, H | 1 |
| Iwasa, M | 1 |
| Sumi, S | 1 |
| Yamada, Y | 1 |
| Ushikoshi, H | 1 |
| Aoyama, T | 1 |
| Nishigaki, K | 1 |
| Takemura, G | 1 |
| Uno, B | 1 |
| Minatoguchi, S | 1 |
| Yan, XF | 1 |
| Zhang, ZM | 1 |
| Yao, HY | 1 |
| Guan, Y | 1 |
| Zhu, JP | 1 |
| Zhang, LH | 1 |
| Jia, YL | 1 |
| Wang, RW | 1 |
| Genescà, M | 1 |
| Sola, A | 1 |
| Miquel, R | 1 |
| Pi, F | 1 |
| Xaus, C | 1 |
| Alfaro, V | 1 |
| Hotter, G | 1 |
| Bostanci, K | 1 |
| Toker, A | 1 |
| Bayrak, Y | 1 |
| Dilege, S | 1 |
| Aykac-Toker, G | 1 |
| Senturk, M | 1 |
| Tugrul, M | 1 |
| Sakamoto, K | 1 |
| Yonoki, Y | 1 |
| Kuwagata, M | 1 |
| Saito, M | 1 |
| Nakahara, T | 1 |
| Ishii, K | 1 |
| Grenz, A | 1 |
| Baier, D | 1 |
| Petroktistis, F | 1 |
| Wehrmann, M | 1 |
| Köhle, C | 1 |
| Schenk, M | 1 |
| Sessler, M | 1 |
| Gleiter, CH | 1 |
| Fandrich, F | 1 |
| Osswald, H | 1 |
| Yildiz, G | 1 |
| Demiryürek, AT | 1 |
| Gümüşel, B | 1 |
| Lippton, H | 1 |
| Langer, JC | 1 |
| Sohal, SS | 1 |
| Mumford, DA | 1 |
| Kawashima, Y | 1 |
| Takeyoshi, I | 1 |
| Furukawa, H | 1 |
| Lee, RG | 1 |
| Todo, S | 1 |
| Bari, F | 1 |
| Louis, TM | 1 |
| Busija, DW | 1 |
| Dunne, JB | 1 |
| Alexander, B | 1 |
| Williams, R | 1 |
| Tredger, JM | 1 |
| Schreieck, J | 1 |
| Richardt, G | 1 |
| Featherstone, RL | 2 |
| Kelly, FJ | 2 |
| Chambers, DJ | 2 |
| Takuma, K | 1 |
| Lee, E | 1 |
| Enomoto, R | 1 |
| Mori, K | 1 |
| Baba, A | 1 |
| Matsuda, T | 1 |
| Pajdo, R | 1 |
| Brzozowski, T | 1 |
| Konturek, PC | 1 |
| Kwiecien, S | 1 |
| Konturek, SJ | 1 |
| Sliwowski, Z | 1 |
| Pawlik, M | 1 |
| Ptak, A | 1 |
| Drozdowicz, D | 1 |
| Hahn, EG | 1 |
| Sugino, H | 1 |
| Shimada, H | 1 |
| Tsuchimoto, K | 1 |
| Kaminski, PM | 1 |
| Proctor, KG | 1 |
| Angello, DA | 1 |
| Headrick, JP | 1 |
| Coddington, NM | 1 |
| Berne, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Perioperative Aminophylline to Improve High Risk Renal Graft Outcome- a Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT01759862] | 50 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| A Multi-Center, Open-Label Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS)[NCT02714036] | Phase 1/Phase 2 | 35 participants (Actual) | Interventional | 2016-05-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The investigators will measure blood creatinine on post-operative day 5 and using the Schwartz equation will calculate estimated glomerular filtration rate (GFR) to determine kidney function. (NCT01759862)
Timeframe: 5 days
| Intervention | ml/min/1.73m2 (Mean) |
|---|---|
| Aminophylline | 67.39 |
| Control | 80.48 |
The investigators will use the same cores that are obtained during routine 6 months protocol biopsies to quantify the amount of fibrosis (NCT01759862)
Timeframe: 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Aminophylline | 11 |
| Control | 14 |
urinary NGAL(Neutrophil gelatinase-associated lipocalin) is a biomarker for kidney injury. NGAL levels 12h post-transplant were found to be a marker for development of delayed graft function and need for dialysis post-transplant. NGAL levels are corrected for urine creatinine. (NCT01759862)
Timeframe: 12 hours post transplant
| Intervention | ng/mg (Median) |
|---|---|
| Aminophylline | 300.5 |
| Control | 425.4 |
22 other studies available for theophylline and Reperfusion Injury
| Article | Year |
|---|---|
Protective effect of theophylline on renal functions in experimental pneumoperitoneum model.
Topics: Acute Kidney Injury; Animals; Biomarkers; Biopsy, Needle; Creatine; Cystatin C; Disease Models, Anim | 2015 |
Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation.
Topics: Animals; Apoptosis; Benzophenanthridines; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; E | 2010 |
Remote ischaemic preconditioning by brief hind limb ischaemia protects against renal ischaemia-reperfusion injury: the role of adenosine.
Topics: Adenosine; Animals; Hindlimb; Ischemic Preconditioning; Kidney; Male; Purinergic P1 Receptor Antagon | 2011 |
Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels.
Topics: Adenosine; Animals; Cardiotonic Agents; Cilostazol; Decanoic Acids; Disease Models, Animal; Drug Eva | 2011 |
Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors.
Topics: Animals; Antioxidants; Cardiotonic Agents; Cordyceps; Glutathione; Glutathione Disulfide; Heart; In | 2013 |
Role of changes in tissular nucleotides on the development of apoptosis during ischemia/reperfusion in rat small bowel.
Topics: Adenosine; Animals; Apoptosis; Caspase 3; Caspases; Cold Temperature; Intestinal Mucosa; Intestine, | 2002 |
Dose-related effects of theophylline added to modified Euro-Collins solution used for hypothermic preservation of lung.
Topics: Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Hypertonic Solutions; Hypothermia, | 2003 |
Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina.
Topics: Adrenergic alpha-Antagonists; Animals; Enzyme Inhibitors; Intraocular Pressure; Ischemia; Ischemic P | 2004 |
Theophylline improves early allograft function in rat kidney transplantation.
Topics: Animals; Cytokines; Disease Models, Animal; Erythropoietin; Glomerular Filtration Rate; Immunohistoc | 2006 |
Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Ischemic Preconditioning; Lung; Male; Malondi | 2007 |
Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs.
Topics: Animals; Animals, Newborn; Cell Membrane Permeability; Cold Temperature; Dose-Response Relationship, | 1993 |
Ischemia and reperfusion injury of the human colon and ileum.
Topics: Adenosine; Allopurinol; Biomarkers; Colon; Glutathione; Humans; Ileum; Insulin; Intestinal Mucosa; M | 1996 |
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excit | 1997 |
Evidence that S-adenosyl-L-methionine diastereoisomers may reduce ischaemia-reperfusion injury by interacting with purinoceptors in isolated rat liver.
Topics: Animals; Bile; Blood Flow Velocity; Enzyme Inhibitors; Glucose; Lactic Acid; Liver; Male; omega-N-Me | 1998 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiogra | 1999 |
Theophylline improves functional recovery of isolated rat lungs after hypothermic preservation.
Topics: Animals; Dose-Response Relationship, Drug; Lung; Lung Compliance; Male; Organ Preservation; Organ Si | 1999 |
Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas' hospital cardioplegic solution used for hypothermic preservation of rat lungs.
Topics: Animals; Bicarbonates; Calcium Chloride; Hypothermia, Induced; Lung; Lung Transplantation; Magnesium | 2000 |
Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model.
Topics: Alkaloids; Animals; Animals, Newborn; Apoptosis; Astrocytes; Carbazoles; Cell Survival; Cyclic GMP; | 2001 |
Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves.
Topics: Adenosine; Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; | 2001 |
Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats.
Topics: Adenosine; Animals; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Ischemia; Ischemic Preco | 2001 |
Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine.
Topics: 2-Chloroadenosine; Adenosine; Aminoimidazole Carboxamide; Animals; Dipyridamole; Intestines; Male; P | 1992 |
Adenosine antagonism decreases metabolic but not functional recovery from ischemia.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Disease; Heart; Hemodynamics; Male; Myocardium; | 1991 |