Page last updated: 2024-10-22

theophylline and Reperfusion Injury

theophylline has been researched along with Reperfusion Injury in 22 studies

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

ExcerptRelevanceReference
" The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction."7.77Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. ( Aoyama, T; Bai, Y; Iwasa, M; Minatoguchi, S; Murakami, H; Nishigaki, K; Sumi, S; Takemura, G; Uno, B; Ushikoshi, H; Yamada, Y, 2011)
"Pretreatment with adenosine receptor antagonists, theophylline or 8-cyclopentyl-1,3-dipropyl xanthine (DPCPX) prior to ischemic preconditioning or adenosine preconditioning abolished the protective effects of preconditioning by ischemic preconditioning and adenosine preconditioning."5.34Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors. ( Demiryürek, AT; Gümüşel, B; Lippton, H; Yildiz, G, 2007)
" The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction."3.77Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. ( Aoyama, T; Bai, Y; Iwasa, M; Minatoguchi, S; Murakami, H; Nishigaki, K; Sumi, S; Takemura, G; Uno, B; Ushikoshi, H; Yamada, Y, 2011)
"To investigate the dose-related effects of theophylline in prevention of ischemia-reperfusion injury of the lung."3.72Dose-related effects of theophylline added to modified Euro-Collins solution used for hypothermic preservation of lung. ( Aykac-Toker, G; Bayrak, Y; Bostanci, K; Dilege, S; Senturk, M; Toker, A; Tugrul, M, 2003)
"We examined the effect of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (ibudilast), which has been clinically used for bronchial asthma and cerebrovascular disorders, on cell viability induced in a model of reperfusion injury."3.71Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model. ( Baba, A; Enomoto, R; Lee, E; Matsuda, T; Mori, K; Takuma, K, 2001)
" In 10-day-old rats, mucosal permeability to 51Cr EDTA was measured after subjecting the animals to 10-minute ischemia-reperfusion injury, 30 minutes of hypoxia (14% oxygen), cold stress (4 degree C for 4 minutes), and intraperitoneal indomethacin (0."3.68Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs. ( Langer, JC; Mumford, DA; Sohal, SS, 1993)
"Pretreatment with adenosine receptor antagonists, theophylline or 8-cyclopentyl-1,3-dipropyl xanthine (DPCPX) prior to ischemic preconditioning or adenosine preconditioning abolished the protective effects of preconditioning by ischemic preconditioning and adenosine preconditioning."1.34Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors. ( Demiryürek, AT; Gümüşel, B; Lippton, H; Yildiz, G, 2007)
"Brief ischemia was reported to protect various cells against injury induced by subsequent ischemia-reperfusion, and this phenomenon is known as ischemic preconditioning."1.32Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina. ( Ishii, K; Kuwagata, M; Nakahara, T; Saito, M; Sakamoto, K; Yonoki, Y, 2004)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (36.36)18.2507
2000's9 (40.91)29.6817
2010's5 (22.73)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ozturk, SA1
Ceylan, C1
Serel, TA1
Doluoglu, OG1
Soyupek, AS1
Guzel, A1
Özorak, A1
Uz, E1
Savas, HB1
Baspinar, S1
Eldaif, SM1
Deneve, JA1
Wang, NP1
Jiang, R1
Mosunjac, M1
Mutrie, CJ1
Guyton, RA1
Zhao, ZQ1
Vinten-Johansen, J1
Wever, KE1
Warlé, MC1
Wagener, FA1
van der Hoorn, JW1
Masereeuw, R1
van der Vliet, JA1
Rongen, GA1
Bai, Y1
Murakami, H1
Iwasa, M1
Sumi, S1
Yamada, Y1
Ushikoshi, H1
Aoyama, T1
Nishigaki, K1
Takemura, G1
Uno, B1
Minatoguchi, S1
Yan, XF1
Zhang, ZM1
Yao, HY1
Guan, Y1
Zhu, JP1
Zhang, LH1
Jia, YL1
Wang, RW1
Genescà, M1
Sola, A1
Miquel, R1
Pi, F1
Xaus, C1
Alfaro, V1
Hotter, G1
Bostanci, K1
Toker, A1
Bayrak, Y1
Dilege, S1
Aykac-Toker, G1
Senturk, M1
Tugrul, M1
Sakamoto, K1
Yonoki, Y1
Kuwagata, M1
Saito, M1
Nakahara, T1
Ishii, K1
Grenz, A1
Baier, D1
Petroktistis, F1
Wehrmann, M1
Köhle, C1
Schenk, M1
Sessler, M1
Gleiter, CH1
Fandrich, F1
Osswald, H1
Yildiz, G1
Demiryürek, AT1
Gümüşel, B1
Lippton, H1
Langer, JC1
Sohal, SS1
Mumford, DA1
Kawashima, Y1
Takeyoshi, I1
Furukawa, H1
Lee, RG1
Todo, S1
Bari, F1
Louis, TM1
Busija, DW1
Dunne, JB1
Alexander, B1
Williams, R1
Tredger, JM1
Schreieck, J1
Richardt, G1
Featherstone, RL2
Kelly, FJ2
Chambers, DJ2
Takuma, K1
Lee, E1
Enomoto, R1
Mori, K1
Baba, A1
Matsuda, T1
Pajdo, R1
Brzozowski, T1
Konturek, PC1
Kwiecien, S1
Konturek, SJ1
Sliwowski, Z1
Pawlik, M1
Ptak, A1
Drozdowicz, D1
Hahn, EG1
Sugino, H1
Shimada, H1
Tsuchimoto, K1
Kaminski, PM1
Proctor, KG1
Angello, DA1
Headrick, JP1
Coddington, NM1
Berne, RM1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Perioperative Aminophylline to Improve High Risk Renal Graft Outcome- a Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT01759862]50 participants (Actual)Interventional2012-11-30Completed
A Multi-Center, Open-Label Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS)[NCT02714036]Phase 1/Phase 235 participants (Actual)Interventional2016-05-06Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Calculated Estimated Glomerular Filtration Rate (eGFR)

The investigators will measure blood creatinine on post-operative day 5 and using the Schwartz equation will calculate estimated glomerular filtration rate (GFR) to determine kidney function. (NCT01759862)
Timeframe: 5 days

Interventionml/min/1.73m2 (Mean)
Aminophylline67.39
Control80.48

Presence of Fibrosis Measured on Protocol Biopsy

The investigators will use the same cores that are obtained during routine 6 months protocol biopsies to quantify the amount of fibrosis (NCT01759862)
Timeframe: 6 months

InterventionParticipants (Count of Participants)
Aminophylline11
Control14

Urinary NGAL (Neutrophil Gelatinase-associated Lipocalin)/ Creatinine Ratio

urinary NGAL(Neutrophil gelatinase-associated lipocalin) is a biomarker for kidney injury. NGAL levels 12h post-transplant were found to be a marker for development of delayed graft function and need for dialysis post-transplant. NGAL levels are corrected for urine creatinine. (NCT01759862)
Timeframe: 12 hours post transplant

Interventionng/mg (Median)
Aminophylline300.5
Control425.4

Other Studies

22 other studies available for theophylline and Reperfusion Injury

ArticleYear
Protective effect of theophylline on renal functions in experimental pneumoperitoneum model.
    Renal failure, 2015, Volume: 37, Issue:6

    Topics: Acute Kidney Injury; Animals; Biomarkers; Biopsy, Needle; Creatine; Cystatin C; Disease Models, Anim

2015
Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation.
    Transplant international : official journal of the European Society for Organ Transplantation, 2010, Volume: 23, Issue:2

    Topics: Animals; Apoptosis; Benzophenanthridines; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; E

2010
Remote ischaemic preconditioning by brief hind limb ischaemia protects against renal ischaemia-reperfusion injury: the role of adenosine.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:10

    Topics: Adenosine; Animals; Hindlimb; Ischemic Preconditioning; Kidney; Male; Purinergic P1 Receptor Antagon

2011
Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels.
    Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:10

    Topics: Adenosine; Animals; Cardiotonic Agents; Cilostazol; Decanoic Acids; Disease Models, Animal; Drug Eva

2011
Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors.
    Phytotherapy research : PTR, 2013, Volume: 27, Issue:11

    Topics: Animals; Antioxidants; Cardiotonic Agents; Cordyceps; Glutathione; Glutathione Disulfide; Heart; In

2013
Role of changes in tissular nucleotides on the development of apoptosis during ischemia/reperfusion in rat small bowel.
    The American journal of pathology, 2002, Volume: 161, Issue:5

    Topics: Adenosine; Animals; Apoptosis; Caspase 3; Caspases; Cold Temperature; Intestinal Mucosa; Intestine,

2002
Dose-related effects of theophylline added to modified Euro-Collins solution used for hypothermic preservation of lung.
    Journal of cardiothoracic and vascular anesthesia, 2003, Volume: 17, Issue:6

    Topics: Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Hypertonic Solutions; Hypothermia,

2003
Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina.
    Brain research, 2004, Jul-23, Volume: 1015, Issue:1-2

    Topics: Adrenergic alpha-Antagonists; Animals; Enzyme Inhibitors; Intraocular Pressure; Ischemia; Ischemic P

2004
Theophylline improves early allograft function in rat kidney transplantation.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:2

    Topics: Animals; Cytokines; Disease Models, Animal; Erythropoietin; Glomerular Filtration Rate; Immunohistoc

2006
Ischemic preconditioning modulates ischemia-reperfusion injury in the rat lung: role of adenosine receptors.
    European journal of pharmacology, 2007, Feb-05, Volume: 556, Issue:1-3

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Ischemic Preconditioning; Lung; Male; Malondi

2007
Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs.
    Journal of pediatric surgery, 1993, Volume: 28, Issue:10

    Topics: Animals; Animals, Newborn; Cell Membrane Permeability; Cold Temperature; Dose-Response Relationship,

1993
Ischemia and reperfusion injury of the human colon and ileum.
    Transplantation proceedings, 1996, Volume: 28, Issue:5

    Topics: Adenosine; Allopurinol; Biomarkers; Colon; Glutathione; Humans; Ileum; Insulin; Intestinal Mucosa; M

1996
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets.
    Stroke, 1997, Volume: 28, Issue:6

    Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excit

1997
Evidence that S-adenosyl-L-methionine diastereoisomers may reduce ischaemia-reperfusion injury by interacting with purinoceptors in isolated rat liver.
    British journal of pharmacology, 1998, Volume: 125, Issue:1

    Topics: Animals; Bile; Blood Flow Velocity; Enzyme Inhibitors; Glucose; Lactic Acid; Liver; Male; omega-N-Me

1998
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1

    Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiogra

1999
Theophylline improves functional recovery of isolated rat lungs after hypothermic preservation.
    The Annals of thoracic surgery, 1999, Volume: 67, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Lung; Lung Compliance; Male; Organ Preservation; Organ Si

1999
Comparison of phosphodiesterase inhibitors of differing isoenzyme selectivity added to St. Thomas' hospital cardioplegic solution used for hypothermic preservation of rat lungs.
    American journal of respiratory and critical care medicine, 2000, Volume: 162, Issue:3 Pt 1

    Topics: Animals; Bicarbonates; Calcium Chloride; Hypothermia, Induced; Lung; Lung Transplantation; Magnesium

2000
Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model.
    British journal of pharmacology, 2001, Volume: 133, Issue:6

    Topics: Alkaloids; Animals; Animals, Newborn; Apoptosis; Astrocytes; Carbazoles; Cell Survival; Cyclic GMP;

2001
Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves.
    European journal of pharmacology, 2001, Sep-21, Volume: 427, Issue:3

    Topics: Adenosine; Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1;

2001
Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats.
    Japanese journal of pharmacology, 2001, Volume: 87, Issue:2

    Topics: Adenosine; Animals; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Ischemia; Ischemic Preco

2001
Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine.
    Circulation research, 1992, Volume: 71, Issue:3

    Topics: 2-Chloroadenosine; Adenosine; Aminoimidazole Carboxamide; Animals; Dipyridamole; Intestines; Male; P

1992
Adenosine antagonism decreases metabolic but not functional recovery from ischemia.
    The American journal of physiology, 1991, Volume: 260, Issue:1 Pt 2

    Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Disease; Heart; Hemodynamics; Male; Myocardium;

1991