theophylline has been researched along with Parkinson Disease in 15 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "theophylline were compared before and after a 4-week period of oral treatment with ropinirole (2 mg t." | 2.69 | Lack of pharmacokinetic interaction between ropinirole and theophylline in patients with Parkinson's disease. ( Brefel-Courbon, C; Eagle, S; Fitzpatrick, K; Rascol, O; Taylor, A; Thalamas, C, 1999) |
| "This tremor is normally recordable at a stable frequency of 8-10 Hz, though this can be influenced by age, the amplitude can vary substantially." | 2.39 | [Most frequent causes for hand tremor in clinical practice]. ( Málly, J, 1995) |
| "Caffeine has been considered a neuroprotective agent against Parkinson's disease (PD)." | 1.48 | Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson's disease. ( Ishii, R; Kasai, T; Kosaka, T; Mizuno, T; Ohmichi, T; Shikata, K; Shinomoto, M; Tatebe, H; Tokuda, T, 2018) |
| "Caffeine half-life was also estimated from salivary concentrations of caffeine at 2 and 5 h post dose." | 1.31 | Parkinson's disease and CYP1A2 activity. ( Forsyth, JT; Grünewald, RA; Lennard, MS; Rostami-Hodjegan, A; Sagar, HJ; Tucker, GT, 2000) |
| " In the therapeutic use of theophylline monitoring of the serum theophylline concentration is generally advised because of the elsewhere reported variability in the biological half-life of the compound." | 1.26 | Pharmacokinetics of theophylline in ten elderly patients. ( Jakobsen, P; Magnussen, I; Nielsen-Kudsk, F, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumura, N | 1 |
| Aoyama, K | 1 |
| Maclagan, LC | 1 |
| Visanji, NP | 1 |
| Cheng, Y | 1 |
| Tadrous, M | 1 |
| Lacoste, AMB | 1 |
| Kalia, LV | 1 |
| Bronskill, SE | 1 |
| Marras, C | 1 |
| Rohilla, S | 1 |
| Bansal, R | 1 |
| Chauhan, P | 1 |
| Kachler, S | 1 |
| Klotz, KN | 1 |
| Janitschke, D | 1 |
| Lauer, AA | 1 |
| Bachmann, CM | 1 |
| Grimm, HS | 1 |
| Hartmann, T | 1 |
| Grimm, MOW | 1 |
| Ohmichi, T | 1 |
| Kasai, T | 1 |
| Kosaka, T | 1 |
| Shikata, K | 1 |
| Tatebe, H | 1 |
| Ishii, R | 1 |
| Shinomoto, M | 1 |
| Mizuno, T | 1 |
| Tokuda, T | 1 |
| Málly, J | 2 |
| Stone, TW | 1 |
| Kostic, VS | 1 |
| Svetel, M | 1 |
| Sternic, N | 1 |
| Dragasevic, N | 1 |
| Przedborski, S | 1 |
| Thalamas, C | 1 |
| Taylor, A | 1 |
| Brefel-Courbon, C | 1 |
| Eagle, S | 1 |
| Fitzpatrick, K | 1 |
| Rascol, O | 1 |
| Forsyth, JT | 1 |
| Grünewald, RA | 1 |
| Rostami-Hodjegan, A | 1 |
| Lennard, MS | 1 |
| Sagar, HJ | 1 |
| Tucker, GT | 1 |
| Kanda, A | 1 |
| Ebihara, S | 1 |
| Arai, H | 1 |
| Takeda, A | 1 |
| Sasaki, H | 1 |
| Nielsen-Kudsk, F | 1 |
| Magnussen, I | 1 |
| Jakobsen, P | 1 |
| Nelson, SR | 1 |
| Walaszek, EJ | 1 |
| Hidaka, H | 1 |
| Shibuya, M | 1 |
| Diemath, HE | 1 |
| Enge, S | 1 |
| Lechner, H | 1 |
4 reviews available for theophylline and Parkinson Disease
| Article | Year |
|---|---|
Glutathione-Mediated Neuroprotective Effect of Purine Derivatives.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Brain; Caffeine; Cysteine; Excitatory Amino Ac | 2023 |
Methylxanthines and Neurodegenerative Diseases: An Update.
Topics: Alzheimer Disease; Animals; Caffeine; Coffee; Humans; Multiple Sclerosis; Neurodegenerative Diseases | 2021 |
[Most frequent causes for hand tremor in clinical practice].
Topics: Aged; Aged, 80 and over; Aging; Female; Hand; Humans; Hypokinesia; Male; Parkinson Disease; Posture; | 1995 |
Pharmacology of the central nervous system.
Topics: Abnormalities, Drug-Induced; Acetylcholine; Adrenocorticotropic Hormone; Amphetamine; Anger; Angiote | 1968 |
2 trials available for theophylline and Parkinson Disease
| Article | Year |
|---|---|
The effect of theophylline on parkinsonian symptoms.
Topics: Administration, Oral; Aged; Aged, 80 and over; Delayed-Action Preparations; Disability Evaluation; F | 1994 |
Lack of pharmacokinetic interaction between ropinirole and theophylline in patients with Parkinson's disease.
Topics: Administration, Oral; Aged; Antiparkinson Agents; Cytochrome P-450 CYP1A2; Dopamine Agonists; Drug I | 1999 |
9 other studies available for theophylline and Parkinson Disease
| Article | Year |
|---|---|
Identifying drugs with disease-modifying potential in Parkinson's disease using artificial intelligence and pharmacoepidemiology.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Artificial Intelligence; Case-Control Studies; Dexame | 2020 |
A New Series of 1,3-Dimethylxanthine Based Adenosine A
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Animals; Molecular Docking Simulation; Parkinson Disea | 2021 |
Biomarker repurposing: Therapeutic drug monitoring of serum theophylline offers a potential diagnostic biomarker of Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Caffeine; Central Nervous System Stimulants; Female; Hum | 2018 |
Theophylline increases "on" time in advanced parkinsonian patients.
Topics: Adult; Humans; Middle Aged; Parkinson Disease; Theophylline; Time Factors | 1999 |
Parkinson's disease and CYP1A2 activity.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Cytochrome P-450 CYP1A2; Female; Humans; Male; Middle Aged | 2000 |
Parkinson's disease and impaired chemosensitivity to hypoxia.
Topics: Caffeine; Humans; Parkinson Disease; Phosphodiesterase Inhibitors; Respiration; Theophylline | 2000 |
Pharmacokinetics of theophylline in ten elderly patients.
Topics: Age Factors; Aged; Female; Half-Life; Hemiplegia; Humans; Injections, Intravenous; Male; Middle Aged | 1978 |
A new assay of cyclic nucleotide phosphodiesterase; its application to human serum.
Topics: Adult; Animals; Brain; Chromatography, Ion Exchange; Cyclic AMP; Cyclic GMP; Glioblastoma; Humans; H | 1974 |
EEG depth leads during stereotaxic brain surgery. A report on 117 cases (5 target points, effects of 13 different drugs).
Topics: Amides; Amygdala; Antimetabolites; Asparagine; Benzoates; Brain; Brain Diseases; Cerebrovascular Cir | 1970 |