theophylline has been researched along with Pancreatic Neoplasms in 17 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oxidative drug metabolizing capacity has been assessed by oral antipyrine and/or theophylline tests in consecutive patients with chronic pancreatitis (CP; alcoholic 24, idiopathic 47), acute pancreatitis (AP; 28) and pancreatic cancer (CA; 11)." | 5.06 | Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease. ( Acheson, DW; Braganza, JM; Houston, JB; Hunt, LP; Rose, P, 1989) |
| "The cell line In-R1-G9 is one of the clones from the hamster insulinoma cell line, In-111-R1, and it produces glucagon." | 3.67 | Effect of phorbol esters on glucagon secretion from a glucagon-secreting clonal cell line. Synergistic effects of A23187 and theophylline. ( Kumae, S; Ono, J; Sato, Y; Takaki, R, 1986) |
| "Cancer cachexia is a multifactorial syndrome characterized by progressive loss of weight and muscle atrophy." | 2.79 | Metabolomics evaluation of serum markers for cachexia and their intra-day variation in patients with advanced pancreatic cancer. ( Azuma, T; Chayahara, N; Fujiwara, Y; Imamura, Y; Kiyota, N; Kobayashi, T; Minami, H; Mukohara, T; Nishiumi, S; Toyoda, M; Yoshida, M, 2014) |
| "The carbachol-induced increase in cAMP levels was inhibited by atropine." | 1.28 | Interaction between phosphoinositide turnover system and cyclic AMP pathway for the secretion of pancreastatin and somatostatin from QGP-1N cells. ( Funakoshi, A; Kitayama, N; Matsuoka, Y; Tateishi, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (52.94) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fujiwara, Y | 1 |
| Kobayashi, T | 1 |
| Chayahara, N | 1 |
| Imamura, Y | 1 |
| Toyoda, M | 1 |
| Kiyota, N | 1 |
| Mukohara, T | 1 |
| Nishiumi, S | 1 |
| Azuma, T | 1 |
| Yoshida, M | 1 |
| Minami, H | 1 |
| Robinette, CD | 1 |
| Sopwith, AM | 1 |
| Hutton, JC | 1 |
| Naber, SP | 1 |
| Chick, WL | 1 |
| Hales, CN | 2 |
| Estival, A | 1 |
| Clemente, F | 1 |
| Ribet, A | 1 |
| Yasunami, Y | 1 |
| Funakoshi, A | 2 |
| Ryu, S | 1 |
| Shinozaki, H | 1 |
| Jimi, A | 1 |
| Miyazaki, K | 1 |
| Ikeda, S | 1 |
| Sjöholm, A | 1 |
| Arkhammar, P | 2 |
| Welsh, N | 1 |
| Bokvist, K | 1 |
| Rorsman, P | 2 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 2 |
| Ku, JC | 1 |
| Liu, MY | 1 |
| Wu, MC | 1 |
| Tateishi, K | 1 |
| Kitayama, N | 1 |
| Matsuoka, Y | 1 |
| Jeng, YJ | 1 |
| Townsend, CM | 1 |
| Nagasawa, S | 1 |
| Chuo, S | 1 |
| Kern, K | 1 |
| Yanaihara, N | 1 |
| Ferrar, RS | 1 |
| Hill, FL | 1 |
| Thompson, JC | 1 |
| Greeley, GH | 1 |
| Iguchi, H | 1 |
| Hayashi, I | 1 |
| Kono, A | 1 |
| Ishihara, K | 1 |
| Taniguchi, H | 1 |
| Ejiri, K | 1 |
| Baba, S | 1 |
| Acheson, DW | 2 |
| Hunt, LP | 1 |
| Rose, P | 2 |
| Houston, JB | 2 |
| Braganza, JM | 2 |
| Flatt, PR | 2 |
| Swanston-Flatt, SK | 2 |
| Powell, CJ | 1 |
| Marks, V | 1 |
| Abrahamsson, H | 1 |
| Carrington, CA | 1 |
| Rubery, ED | 1 |
| Pearson, EC | 1 |
| Ono, J | 1 |
| Kumae, S | 1 |
| Sato, Y | 1 |
| Takaki, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for theophylline and Pancreatic Neoplasms
| Article | Year |
|---|---|
Metabolomics evaluation of serum markers for cachexia and their intra-day variation in patients with advanced pancreatic cancer.
Topics: Adult; Aged; Biomarkers; Cachexia; Female; Humans; Interleukin-6; Leptin; Male; Metabolomics; Middle | 2014 |
Factors contributing to the accelerated clearance of theophylline and antipyrine in adults with exocrine pancreatic disease.
Topics: Adult; Aged; Alcohol Drinking; Antipyrine; Enzyme Induction; Female; Humans; Male; Metabolic Clearan | 1989 |
15 other studies available for theophylline and Pancreatic Neoplasms
| Article | Year |
|---|---|
Methylated xanthines and pancreatic cancer.
Topics: Bronchodilator Agents; Coffee; Humans; Male; Methylation; Pancreatic Neoplasms; Theophylline; Xanthi | 1981 |
Insulin secretion by a transplantable rat islet cell tumour.
Topics: Adenoma, Islet Cell; Animals; Colchicine; Epinephrine; Glucagon; Glucose; Insulin; Insulin Secretion | 1981 |
Adenocarcinoma of the human exocrine pancreas: presence of secretin and caerulein receptors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenocarcinoma; Animals; C | 1981 |
In vitro release of vasoactive intestinal polypeptide and pancreatic polypeptide from human VIPoma cells and its inhibition by somatostatin analogue (SMS 201-995).
Topics: Adult; Atropine; Carbachol; Ceruletide; Dose-Response Relationship, Drug; Female; Humans; Immunohist | 1994 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Stimulation of macrophage colony-stimulating factor synthesis by interleukin-1.
Topics: Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; Gene Expression Regulation, Neoplastic; Humans; I | 1992 |
Interaction between phosphoinositide turnover system and cyclic AMP pathway for the secretion of pancreastatin and somatostatin from QGP-1N cells.
Topics: Adenoma, Islet Cell; Atropine; Bucladesine; Calcimycin; Carbachol; Cell Line; Chromogranin A; Colfor | 1992 |
Regulation of pancreastatin release from a human pancreatic carcinoid cell line in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Carcinoid Tumor; Cell Line; Chr | 1991 |
A somatostatin-secreting cell line established from a human pancreatic islet cell carcinoma (somatostatinoma): release experiment and immunohistochemical study.
Topics: Adenoma, Islet Cell; Animals; Carcinoembryonic Antigen; Glucagon; Humans; Insulin; Insulin Secretion | 1990 |
Effect of the cooling rate on insulin release from frozen-thawed In-111 cells.
Topics: Animals; Cell Line; Cold Temperature; Cricetinae; Freezing; Glucose; Insulin; Insulin Secretion; Ins | 1991 |
Defective regulation of insulin release and transmembrane Ca2+ fluxes by human islet cell tumours.
Topics: Adenoma, Islet Cell; Adolescent; Calcium; Female; Humans; Insulin; Insulin Secretion; Insulinoma; Io | 1987 |
Measurements of membrane potential, transmembrane 45Ca fluxes, cytoplasmic free Ca2+ concentration and insulin release by transplantable rat insulinoma cells maintained in tissue culture.
Topics: Adenoma, Islet Cell; Animals; Bucladesine; Calcium; Calcium Channel Blockers; Cytoplasm; Glucose; In | 1988 |
Five new insulin-producing cell lines with differing secretory properties.
Topics: Adenoma, Islet Cell; Animals; Calcium; Cell Line; Glucagon; Glucose; Insulin; Insulin Secretion; Leu | 1986 |
Effect of phorbol esters on glucagon secretion from a glucagon-secreting clonal cell line. Synergistic effects of A23187 and theophylline.
Topics: Adenoma, Islet Cell; Animals; Calcimycin; Cell Line; Clone Cells; Cricetinae; Drug Synergism; Glucag | 1986 |
Induction of cytochromes P-450 in pancreatic disease: consequence, coincidence or cause?
Topics: Adolescent; Adult; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Half-Life; | 1985 |