theophylline has been researched along with Obesity in 82 studies
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since passage of the Dietary Supplement Health and Education Act of 1994, the sale of herbal dietary supplements containing caffeine and ephedrine for weight loss has become widespread in the United States." | 8.81 | The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent. ( Greenway, FL, 2001) |
| "The effect of ephedrine (E) and theophylline (T), administered alone and in combination (E/T), on weight loss, resting energy expenditure and post-heparin lipoprotein lipase activity in plasma (PHLA) and in adipose tissue (ATLP) were investigated in obese over-fed rats, who had been diet restricted (-40% of normal caloric intake) for three weeks." | 7.68 | Effect of ephedrine and theophylline on weight loss, resting energy expenditure and lipoprotein lipase activity in obese over-fed rats. ( Malecka-Tendera, E, 1993) |
| "The volume of distribution (Vd) of theophylline and the relevant aminophylline loading dose (LD) are usually calculated on the basis of total body weight (TBW)." | 7.67 | Effect of body weight on the volume of distribution of theophylline. ( Bonanno, A; Mirabella, A; Rizzo, A, 1988) |
| "Administration of a thermogenic mixture of ephedrine, caffeine and theophylline to grossly obese (11-12 mo old) fa/fa Zucker rats led to a rapid decline in their body weight, which reached lean levels within 9-10 wk, and this postobese weight was maintained for another 5-6 wk." | 7.67 | Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture. ( Dulloo, AG; Miller, DS, 1987) |
| "The effect of obesity on the total body clearance (Cltot) of theophylline was evaluated in nonsmokers and smokers with and without congestive heart failure (CHF)." | 7.66 | Theophylline clearance in obese patients in relation to smoking and congestive heart failure. ( Lanc, RA; Slaughter, RL, 1983) |
| "Theophylline preparations have long been the mainstay in the management of asthma." | 7.66 | Intravenous theophylline therapy in asthma: a clinical update. ( Rothstein, RJ, 1980) |
| "Total body clearance (ClT) of theophylline was examined in 12 markedly obese patients and related to total body weight (TBW) and ideal body weight (IBW)." | 7.66 | Theophylline clearance: effect of marked obesity. ( Bauer, LA; Blouin, RA; Elgert, JF, 1980) |
| "Theophylline disposition was examined in 14 obese subjects and 57 normal subjects." | 5.26 | Theophylline disposition in obesity. ( Franklin, BA; Gal, P; Jusko, WJ; Yurchak, AM, 1978) |
| " Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline." | 5.12 | Effect of obesity on clinical presentation and response to treatment in asthma. ( Allayee, H; Cohen, RI; Dixon, AE; Holbrook, JT; Irvin, CG; Lima, JJ; Shade, DM; Skloot, GS; Smith, LJ; Wise, RA, 2006) |
| "Theophylline plasma levels and FEV1 were measured in patients affected by chronic obstructive pulmonary disease and a concomitant disease state (congestive heart failure, chronic cor pulmonale, obesity, peptic disease, hepatic cirrhosis, chronic renal failure) and treated with a sustained release theophylline preparation." | 5.06 | Effect of various disease states on theophylline plasma levels and on pulmonary function in patients with chronic airway obstruction treated with a sustained release theophylline preparation. ( Dal Negro, R; Monici-Preti, P; Pomari, C; Turco, P, 1987) |
| "The thermogenic effect of an over-the-counter preparation containing 22 mg ephedrine, 30 mg caffeine and 50 mg theophylline was investigated in human volunteers with a predisposition to obesity and also in the lean." | 5.06 | The thermogenic properties of ephedrine/methylxanthine mixtures: human studies. ( Dulloo, AG; Miller, DS, 1986) |
| "Since passage of the Dietary Supplement Health and Education Act of 1994, the sale of herbal dietary supplements containing caffeine and ephedrine for weight loss has become widespread in the United States." | 4.81 | The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent. ( Greenway, FL, 2001) |
| " Although more controlled studies would be helpful, relatively clear-cut indications for the use of ventilatory stimulants exist for hypercapnic obesity-hypoventilation patients (medroxyprogesterone), myxedema (thyroid replacement), central apnea (acetazolamide), and periodic breathing in congestive heart failure (theophylline)." | 4.80 | Pharmacologic treatment of sleep-disordered breathing. ( Hudgel, DW; Thanakitcharu, S, 1998) |
| "This study does not support an increased risk of childhood obesity with increasing maternal caffeine consumption during pregnancy." | 3.81 | Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years. ( Keim, SA; Klebanoff, MA, 2015) |
| "Our findings indicate that obese rats possess altered adenosinergic modulation of ventilatory responses to acute and sustained hypoxia in two opposite ways." | 3.73 | Adenosinergic modulation of ventilation in obese zucker rats. ( Farkas, GA; Lee, SD; Nakano, H, 2005) |
| "The effect of ephedrine (E) and theophylline (T), administered alone and in combination (E/T), on weight loss, resting energy expenditure and post-heparin lipoprotein lipase activity in plasma (PHLA) and in adipose tissue (ATLP) were investigated in obese over-fed rats, who had been diet restricted (-40% of normal caloric intake) for three weeks." | 3.68 | Effect of ephedrine and theophylline on weight loss, resting energy expenditure and lipoprotein lipase activity in obese over-fed rats. ( Malecka-Tendera, E, 1993) |
| " Verofylline, a lipophilic polysubstituted methylxanthine, was utilized to examine how severely altered body composition in obesity affects drug disposition; the role of fat-free mass, fat mass and protein binding in determining the volume of distribution (Vss) was investigated." | 3.68 | Verofylline pharmacokinetics in dietary-induced obese rats: role of fat mass and protein binding in determining volume of distribution. ( Jusko, WJ; Shum, L, 1991) |
| "A dietary-induced animal model of obesity was examined to assess the mechanisms of obesity-altered changes in theophylline clearance and distribution." | 3.67 | Theophylline disposition in obese rats. ( Jusko, WJ; Shum, L, 1984) |
| "The volume of distribution (Vd) of theophylline and the relevant aminophylline loading dose (LD) are usually calculated on the basis of total body weight (TBW)." | 3.67 | Effect of body weight on the volume of distribution of theophylline. ( Bonanno, A; Mirabella, A; Rizzo, A, 1988) |
| "Administration of a thermogenic mixture of ephedrine, caffeine and theophylline to grossly obese (11-12 mo old) fa/fa Zucker rats led to a rapid decline in their body weight, which reached lean levels within 9-10 wk, and this postobese weight was maintained for another 5-6 wk." | 3.67 | Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture. ( Dulloo, AG; Miller, DS, 1987) |
| "The effect of obesity on the total body clearance (Cltot) of theophylline was evaluated in nonsmokers and smokers with and without congestive heart failure (CHF)." | 3.66 | Theophylline clearance in obese patients in relation to smoking and congestive heart failure. ( Lanc, RA; Slaughter, RL, 1983) |
| "Theophylline preparations have long been the mainstay in the management of asthma." | 3.66 | Intravenous theophylline therapy in asthma: a clinical update. ( Rothstein, RJ, 1980) |
| "Total body clearance (ClT) of theophylline was examined in 12 markedly obese patients and related to total body weight (TBW) and ideal body weight (IBW)." | 3.66 | Theophylline clearance: effect of marked obesity. ( Bauer, LA; Blouin, RA; Elgert, JF, 1980) |
| " Safety with long-term use requires further investigation." | 2.70 | An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. ( Boozer, CN; Chen, G; Heymsfield, SB; Nasser, JA; Solomon, JL; Wang, V, 2001) |
| "Body weight reductions were 0." | 2.70 | Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients. ( Andersen, T; Fogh, J, 2001) |
| "Treatment of GERD is mainly drug therapy; however, it is believed that providing guidance in changing life-style and providing information about the disease will permit long-lasting relief of the symptoms." | 2.42 | [GERD: guidance in changing life-style]. ( Harasawa, S; Nagoshi, A, 2004) |
| "He was subsequently diagnosed with sleep apnea associated with frequent and significant sinus pauses." | 1.42 | Sleep apnea and severe bradyarrhythmia--an alternative treatment option: a case report. ( Ahmed, W; Al-Faifi, SM; Alsheikh-Ali, AA; Asrar, F; Daoulah, A; Lotfi, A; Ocheltree, S, 2015) |
| " Incorporation of the relevant physiological and biochemical changes into predictive bottom-up pharmacokinetic models in order to optimize dosage regimens may offer a logical way forward for the cases where no clinical data exist." | 1.37 | Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance. ( Aarabi, M; Allabi, AC; Almond, LM; Ghobadi, C; Jamei, M; Johnson, TN; Rostami-Hodjegan, A; Rowland-Yeo, K, 2011) |
| " This study suggests that the long-term intake of the dietary supplement inducing CYP1A2 may increase the incidence of colorectal cancers caused by procarcinogens activated by CYP1A2 in rapid N-acetyltransferase-2 acetylators and of lung adenocarcinoma in slow acetylators." | 1.32 | Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans. ( Chung, WG; Ryu, SD, 2003) |
| " Frequent dosage adjustments were required to maintain theophylline concentrations within the range of 8." | 1.27 | Intrasubject variability of theophylline clearance in a morbidly obese patient. ( Nairn, D; Slaughter, RL, 1986) |
| "Obesity is a circumstance characterized in the dog fat cell by a modification of the balance between alpha-2 and beta receptors." | 1.26 | Alpha-2 adrenergic antilipolytic effect in dog fat cells: incidence of obesity and adipose tissue localization. ( Berlan, M; Carpene, C; Dang-Tran, L; Lafontan, M, 1982) |
| "Theophylline disposition was examined in 14 obese subjects and 57 normal subjects." | 1.26 | Theophylline disposition in obesity. ( Franklin, BA; Gal, P; Jusko, WJ; Yurchak, AM, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (70.73) | 18.7374 |
| 1990's | 9 (10.98) | 18.2507 |
| 2000's | 9 (10.98) | 29.6817 |
| 2010's | 4 (4.88) | 24.3611 |
| 2020's | 2 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, TT | 1 |
| Liu, XT | 1 |
| Huang, GL | 1 |
| Liu, L | 1 |
| Chen, QX | 1 |
| Wang, Q | 1 |
| Qu, W | 1 |
| Chen, Z | 1 |
| Hu, X | 1 |
| Zou, T | 1 |
| Huang, Y | 1 |
| Zhang, Y | 1 |
| Hu, Y | 1 |
| Tian, S | 1 |
| Wan, J | 1 |
| Liao, R | 1 |
| Bai, L | 1 |
| Xue, J | 1 |
| Ding, Y | 1 |
| Hu, M | 1 |
| Zhang, XJ | 1 |
| Zhang, X | 1 |
| Zhao, J | 1 |
| Cheng, X | 1 |
| She, ZG | 1 |
| Li, H | 1 |
| Klebanoff, MA | 1 |
| Keim, SA | 1 |
| Daoulah, A | 1 |
| Ocheltree, S | 1 |
| Al-Faifi, SM | 1 |
| Ahmed, W | 1 |
| Alsheikh-Ali, AA | 1 |
| Asrar, F | 1 |
| Lotfi, A | 1 |
| Bojko, B | 1 |
| Sułkowska, A | 1 |
| Maciazek-Jurczyk, M | 1 |
| Równicka, J | 1 |
| Sułkowski, WW | 1 |
| Ghobadi, C | 1 |
| Johnson, TN | 1 |
| Aarabi, M | 1 |
| Almond, LM | 1 |
| Allabi, AC | 1 |
| Rowland-Yeo, K | 1 |
| Jamei, M | 1 |
| Rostami-Hodjegan, A | 1 |
| Greenway, FL | 1 |
| Ryu, SD | 1 |
| Chung, WG | 1 |
| DUMON, G | 1 |
| BROUILLET-GABRIEL, MT | 1 |
| PASQUET, P | 1 |
| Nagoshi, A | 1 |
| Harasawa, S | 1 |
| Lee, SD | 1 |
| Nakano, H | 1 |
| Farkas, GA | 1 |
| Flechtner-Mors, M | 1 |
| Jenkinson, CP | 1 |
| Alt, A | 1 |
| Biesalski, HK | 1 |
| Adler, G | 1 |
| Ditschuneit, HH | 1 |
| Dixon, AE | 1 |
| Shade, DM | 1 |
| Cohen, RI | 1 |
| Skloot, GS | 1 |
| Holbrook, JT | 1 |
| Smith, LJ | 1 |
| Lima, JJ | 1 |
| Allayee, H | 1 |
| Irvin, CG | 1 |
| Wise, RA | 1 |
| Berlan, M | 3 |
| Dang-Tran, L | 2 |
| Lafontan, M | 2 |
| Denard, Y | 1 |
| Carpene, C | 1 |
| Challis, RA | 1 |
| Budohoski, L | 1 |
| McManus, B | 1 |
| Newsholme, EA | 1 |
| Shum, L | 2 |
| Jusko, WJ | 4 |
| Rozen, R | 1 |
| Banegas, E | 1 |
| Davilla, M | 1 |
| Apfelbaum, M | 1 |
| Slaughter, RL | 2 |
| Lanc, RA | 1 |
| Rohrbaugh, TM | 1 |
| Danish, M | 2 |
| Ragni, MC | 1 |
| Yaffe, SJ | 2 |
| Rothstein, RJ | 1 |
| Blouin, RA | 1 |
| Elgert, JF | 1 |
| Bauer, LA | 1 |
| Malecka-Tendera, E | 1 |
| Zahorska-Markiewicz, B | 1 |
| Waluga, M | 1 |
| Zieliñski, M | 1 |
| Klin, M | 1 |
| Hudgel, DW | 1 |
| Thanakitcharu, S | 1 |
| Mauriège, P | 2 |
| Brochu, M | 1 |
| Prud'homme, D | 1 |
| Tremblay, A | 2 |
| Nadeau, A | 1 |
| Lemieux, S | 1 |
| Després, JP | 1 |
| Stich, V | 1 |
| de Glisezinski, I | 1 |
| Galitzky, J | 1 |
| Hejnova, J | 1 |
| Crampes, F | 1 |
| Rivière, D | 1 |
| Imbeault, P | 1 |
| Després, J | 1 |
| Boozer, CN | 1 |
| Nasser, JA | 1 |
| Heymsfield, SB | 1 |
| Wang, V | 1 |
| Chen, G | 1 |
| Solomon, JL | 1 |
| Andersen, T | 1 |
| Fogh, J | 1 |
| Gardner, MJ | 1 |
| Mangione, A | 1 |
| Schentag, JJ | 1 |
| Koup, JR | 1 |
| Vance, JW | 1 |
| Burns, TW | 1 |
| Terry, BE | 1 |
| Langley, PE | 1 |
| Robison, GA | 1 |
| Dehaye, JP | 1 |
| Winand, J | 1 |
| Poloczek, P | 1 |
| Christophe, J | 1 |
| Chiodini, G | 1 |
| Bertolini, S | 1 |
| Elicio, N | 1 |
| Valice, S | 1 |
| Reggiani, E | 1 |
| Di Marco, E | 1 |
| Pronzato, P | 1 |
| Gal, P | 1 |
| Yurchak, AM | 1 |
| Franklin, BA | 1 |
| Prosinska-Kibler, M | 1 |
| Wiemann, J | 1 |
| Sanner, B | 1 |
| Sturm, A | 1 |
| Atef, N | 1 |
| Brulé, C | 1 |
| Bihoreau, MT | 1 |
| Ktorza, A | 1 |
| Picon, L | 1 |
| Pénicaud, L | 1 |
| Lebrazi, H | 1 |
| Chomard, P | 1 |
| Dumas, P | 1 |
| Autissier, N | 1 |
| Vannucci, SJ | 1 |
| Klim, CM | 1 |
| Martin, LF | 1 |
| LaNoue, KF | 1 |
| Lombard, RM | 1 |
| Zwillich, CW | 1 |
| Rizzo, A | 1 |
| Mirabella, A | 1 |
| Bonanno, A | 1 |
| Dal Negro, R | 1 |
| Turco, P | 1 |
| Pomari, C | 1 |
| Monici-Preti, P | 1 |
| Juan, D | 1 |
| Shin, SG | 1 |
| Holmes, T | 1 |
| Hughes, RL | 1 |
| Richelsen, B | 1 |
| Miller, DS | 4 |
| Dulloo, AG | 3 |
| Visram, N | 1 |
| Friesen, EG | 1 |
| Jamali, F | 1 |
| Nairn, D | 1 |
| Herberg, L | 2 |
| Berger, M | 2 |
| Gries, FA | 3 |
| Hellman, B | 5 |
| Idahl, LA | 5 |
| Lernmark, A | 4 |
| Sehlin, J | 3 |
| Täljedal, IB | 3 |
| Mengel, K | 1 |
| Schwabe, U | 1 |
| Steinmetz, J | 2 |
| Lowry, L | 1 |
| Yen, TT | 3 |
| Hesse-Wortmann, C | 2 |
| Bray, GA | 1 |
| Mothon, S | 1 |
| Cohen, AS | 1 |
| Kjellberg, J | 1 |
| Ostman, J | 2 |
| Neumann, M | 1 |
| Preiss, H | 1 |
| Liebermeister, H | 1 |
| Jahnke, K | 1 |
| Shah, PP | 1 |
| English, PD | 1 |
| Bunyan, J | 1 |
| Lovell-Smith, CJ | 1 |
| Sneyd, JG | 1 |
| Backman, L | 1 |
| Hallberg, D | 1 |
| Wolff, GL | 1 |
| Gutzeit, A | 1 |
| Rabinovitch, A | 1 |
| Karakash, C | 1 |
| Stauffacher, W | 1 |
| Renold, AE | 1 |
| Cerasi, E | 1 |
| Atkins, T | 1 |
| Matty, AJ | 1 |
| Tulloch, BR | 1 |
| Vydelingum, N | 1 |
| Galton, DJ | 1 |
| Chiumello, G | 1 |
| Del Guercio, MJ | 1 |
| Di Natale, B | 1 |
| Devetta, M | 1 |
| Caccamo, A | 1 |
| Steinmetz, JA | 1 |
| Meigen, B | 1 |
| Fallen, H | 1 |
| Di Maria, G | 1 |
| Ciammaichella, A | 1 |
| Goldrick, RB | 1 |
| McLoughlin, GM | 1 |
| Vague, J | 1 |
| Miller, G | 1 |
| Teitelbaum, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Diet and Treatment With a Combination of Ephedrine and Caffeine on Thermogenesis, Cardiac Function and on Uncoupling Proteins Expression in Adipose and Muscle Tissue of Morbid Obese Patients Undergoing Bariatric Surgery.[NCT02048215] | Phase 3 | 13 participants (Actual) | Interventional | 2000-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for theophylline and Obesity
| Article | Year |
|---|---|
The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent.
Topics: Aminophylline; Animals; Caffeine; Ephedrine; Humans; Obesity; Plant Preparations; Theophylline; Weig | 2001 |
[GERD: guidance in changing life-style].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Constipation; Diet; Gastroesophag | 2004 |
Pharmacologic treatment of sleep-disordered breathing.
Topics: Acetazolamide; Antihypertensive Agents; Apnea; Bronchodilator Agents; Diuretics; Dyspnea; Evidence-B | 1998 |
[Sleep apnea syndrome].
Topics: Diagnosis, Differential; Electrocardiography; Female; Heart Diseases; Humans; Male; Middle Aged; Obe | 1992 |
Medical therapy of obstructive sleep apnea.
Topics: Almitrine; Central Nervous System Stimulants; Diet, Reducing; Humans; Intubation; Male; Naloxone; Na | 1985 |
The role of calcium in insulin secretion.
Topics: Animals; Butyrates; Calcium; Calcium Isotopes; Cyclic AMP; Glucose; Glyburide; Hyperglycemia; Insuli | 1973 |
8 trials available for theophylline and Obesity
| Article | Year |
|---|---|
Studies of phosphodiesterase effects on adipose tissue metabolism in obese subjects by the microdialysis technique.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adult; Cyclic AMP; Electric Impedance; Female; Glucose; G | 2005 |
Effect of obesity on clinical presentation and response to treatment in asthma.
Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Cyclopropanes; Cytokines; Dis | 2006 |
An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial.
Topics: Adult; Anthropometry; Blood Pressure; Caffeine; Dietary Supplements; Double-Blind Method; Drug Combi | 2001 |
Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients.
Topics: Caffeine; Double-Blind Method; Female; Gastric Emptying; Humans; Ilex paraguariensis; Male; Obesity; | 2001 |
Effect of various disease states on theophylline plasma levels and on pulmonary function in patients with chronic airway obstruction treated with a sustained release theophylline preparation.
Topics: Clinical Trials as Topic; Delayed-Action Preparations; Digestive System Diseases; Heart Diseases; Hu | 1987 |
A controlled trial using ephedrine in the treatment of obesity.
Topics: Caffeine; Clinical Trials as Topic; Drug Combinations; Ephedrine; Humans; Obesity; Theophylline | 1986 |
The thermogenic properties of ephedrine/methylxanthine mixtures: human studies.
Topics: Adult; Basal Metabolism; Body Temperature Regulation; Caffeine; Calorimetry; Disease Susceptibility; | 1986 |
[Experiences with Metabolan in the therapy of fatty liver].
Topics: Adult; Aged; Diet, Reducing; Drug Combinations; Fatty Liver; Humans; Male; Middle Aged; Nicotinic Ac | 1973 |
68 other studies available for theophylline and Obesity
| Article | Year |
|---|---|
Theophylline Extracted from Fu Brick Tea Affects the Metabolism of Preadipocytes and Body Fat in Mice as a Pancreatic Lipase Inhibitor.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Diet, High-Fat; Humans; Lipase; Mice; Mice, Obese; Obesity; R | 2022 |
Profound Perturbation in the Metabolome of a Canine Obesity and Metabolic Disorder Model.
Topics: Animals; Caffeine; Dogs; Harmine; Male; Metabolic Diseases; Metabolome; Obesity; Theophylline | 2022 |
Maternal serum paraxanthine during pregnancy and offspring body mass index at ages 4 and 7 years.
Topics: Adult; Biomarkers; Body Mass Index; Caffeine; Case-Control Studies; Child; Child, Preschool; Female; | 2015 |
Sleep apnea and severe bradyarrhythmia--an alternative treatment option: a case report.
Topics: Bradycardia; Humans; Male; Middle Aged; Obesity; Polysomnography; Sleep Apnea Syndromes; Theophyllin | 2015 |
The influence of dietary habits and pathological conditions on the binding of theophylline to serum albumin.
Topics: Binding Sites; Diabetes Mellitus; Fatty Acids; Feeding Behavior; Humans; Kinetics; Nuclear Magnetic | 2010 |
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
Topics: Adolescent; Adult; Aged; Benzodiazepines; Body Weights and Measures; Caffeine; Chlorzoxazone; Comput | 2011 |
Induction of the procarcinogen-activating CYP1A2 by a herbal dietary supplement in rats and humans.
Topics: Animals; Blotting, Western; Caffeine; Carcinogens; Cytochrome P-450 CYP1A2; Dietary Supplements; Dos | 2003 |
[1ST CLINICAL CONSIDERATIONS ON THE ASSOCIATION OF A SULFAMIDE DIURETIC AND A XANTHINE DERIVATIVE IN TREATMENT OF CARDIOPULMONARY DISEASES].
Topics: Biomedical Research; Diuretics; Drug Therapy; Heart Diseases; Humans; Obesity; Piperazines; Respirat | 1964 |
Adenosinergic modulation of ventilation in obese zucker rats.
Topics: Adenosine; Aminophylline; Animals; Carbon Dioxide; Hypercapnia; Hypoxia; Male; Obesity; Oxygen; Oxyg | 2005 |
Influence of hypocaloric diet on alpha-adrenergic responsiveness of obese human subcutaneous adipocytes.
Topics: Adipose Tissue; Adolescent; Adult; Diet, Reducing; Energy Intake; Epinephrine; Female; Glucose Toler | 1981 |
Alpha-2 adrenergic antilipolytic effect in dog fat cells: incidence of obesity and adipose tissue localization.
Topics: Adipose Tissue; Animals; Clonidine; Dogs; Epinephrine; Isoproterenol; Lipolysis; Obesity; Prazosin; | 1982 |
Effects of an adenosine-receptor antagonist on insulin-resistance in soleus muscle from obese Zucker rats.
Topics: Animals; Glycogen; Glycolysis; In Vitro Techniques; Insulin; Lactates; Lactic Acid; Male; Muscles; O | 1984 |
Theophylline disposition in obese rats.
Topics: Animals; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Fats; Female; | 1984 |
Effects of a very-low-calorie diet on adrenergic responsiveness in human adipose tissue.
Topics: Adipose Tissue; Adult; Clonidine; Diet, Reducing; Female; Humans; Isoproterenol; Lipolysis; Middle A | 1984 |
Theophylline clearance in obese patients in relation to smoking and congestive heart failure.
Topics: Adult; Aged; Body Weight; Female; Heart Failure; Humans; Male; Metabolic Clearance Rate; Middle Aged | 1983 |
The effect of obesity on apparent volume of distribution of theophylline.
Topics: Adipose Tissue; Adult; Female; Half-Life; Humans; Kinetics; Male; Obesity; Theophylline; Time Factor | 1982 |
Intravenous theophylline therapy in asthma: a clinical update.
Topics: Adenosine Monophosphate; Age Factors; Asthma; Diet; Drug Interactions; Humans; Injections, Intraveno | 1980 |
Theophylline clearance: effect of marked obesity.
Topics: Adult; Aged; Body Weight; Female; Heart Failure; Humans; Kidney Diseases; Male; Metabolic Clearance | 1980 |
Effect of ephedrine and theophylline on weight loss, resting energy expenditure and lipoprotein lipase activity in obese over-fed rats.
Topics: Animals; Basal Metabolism; Cholesterol; Diet; Energy Intake; Energy Metabolism; Ephedrine; Lipoprote | 1993 |
Pharmacokinetics of theophylline in obesity.
Topics: Adult; Bronchodilator Agents; Diet; Female; Humans; Middle Aged; Obesity; Theophylline; Weight Loss | 1996 |
Is visceral adiposity a significant correlate of subcutaneous adipose cell lipolysis in men?
Topics: Abdomen; Adenosine Deaminase; Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Adult; Body Cons | 1999 |
Endurance training increases the beta-adrenergic lipolytic response in subcutaneous adipose tissue in obese subjects.
Topics: Adipose Tissue; Adrenergic beta-Agonists; Adult; Exercise; Fatty Acids, Nonesterified; Glucose Toler | 1999 |
beta-adrenoceptor-stimulated lipolysis of subcutaneous abdominal adipocytes as a determinant of fat oxidation in obese men.
Topics: Abdomen; Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Adult; Bucladesine; Cells, Cultured; | 2000 |
Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol.
Topics: Adult; Aging; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Cannabis; Contraceptives, Oral, Ho | 1979 |
In-vitro observations on isolated adipose tissue cells from hyperobese subjects.
Topics: Adipose Tissue; Adult; Cyclic AMP; Epinephrine; Female; Glycerol; Humans; Insulin; Lipid Metabolism; | 1977 |
Relationship between lipolysis and calcium in epididymal adipose tissue of obese-hyperglycaemic mice.
Topics: Adenosine Triphosphate; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Bucladesine; Calcium; | 1979 |
[Fat cell lipolysis induced by theophylline in obese subjects before and after caloric restriction].
Topics: Adipose Tissue; Adolescent; Adult; Diet, Reducing; Female; Humans; Lipid Metabolism; Lipolysis; Male | 1979 |
Theophylline disposition in obesity.
Topics: Adult; Aminophylline; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Obesity; Theophylline | 1978 |
Problems of drug administration in the pediatric patient.
Topics: Age Factors; Child; Disease; Drug Interactions; Humans; Intestinal Absorption; Obesity; Patient Comp | 1978 |
[A case of bradycardia].
Topics: Bradycardia; Electrocardiography; Humans; Hypertension; Male; Middle Aged; Obesity; Theophylline | 1975 |
Verofylline pharmacokinetics in dietary-induced obese rats: role of fat mass and protein binding in determining volume of distribution.
Topics: Adipose Tissue; Animals; Blood Proteins; Body Composition; Muscles; Obesity; Protein Binding; Rats; | 1991 |
Enhanced insulin secretory response to acetylcholine by perifused pancreas of 5-day-old preobese Zucker rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Arginine; Disease Susceptibility; Glucose; Insulin; Insuli | 1991 |
Lipolysis in isolated epididymal adipocytes from genetically obese Zucker rat treated with 3,5,3'-L-triiodothyronine.
Topics: Adipose Tissue; Animals; Epididymis; Epinephrine; Glycerol; Isoproterenol; Lipolysis; Male; Obesity; | 1990 |
A1-adenosine receptor-mediated inhibition of adipocyte adenylate cyclase and lipolysis in Zucker rats.
Topics: Adenosine; Adenosine Deaminase; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adipose Tissue | 1989 |
Effect of body weight on the volume of distribution of theophylline.
Topics: Adult; Aged; Asthma; Body Weight; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Age | 1988 |
Diet-induced changes in trough theophylline concentrations in an elderly asthmatic patient.
Topics: Aged; Asthma; Diet, Reducing; Humans; Male; Obesity; Theophylline | 1988 |
Prostaglandin E2 action and binding in human adipocytes: effects of sex, age, and obesity.
Topics: Adenosine Deaminase; Adipose Tissue; Adolescent; Adult; Age Factors; Aged; Clonidine; Dinoprostone; | 1988 |
Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture.
Topics: Animals; Body Temperature Regulation; Body Weight; Caffeine; Drug Therapy, Combination; Eating; Ener | 1987 |
Theophylline loading dose in obese patients.
Topics: Adult; Aminophylline; Body Weight; Female; Humans; Hypotension; Obesity; Theophylline | 1987 |
Intrasubject variability of theophylline clearance in a morbidly obese patient.
Topics: Female; Humans; Middle Aged; Obesity; Theophylline | 1986 |
Prevention of genetic fa/fa obesity with an ephedrine-methylxanthines thermogenic mixture.
Topics: Animals; Body Composition; Body Temperature Regulation; Caffeine; Energy Intake; Energy Metabolism; | 1987 |
Comparative investigations on lipolysis and re-esterification in adipose tissue of man and various species of mice.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Adult; Animals; Cyclic AMP; Epididymis; Fasting; Fatty | 1974 |
Iodoacetamide-induced sensitization of the pancreatic beta-cells to glucose stimulation.
Topics: Amides; Animals; Calcium; Carbon Isotopes; Dithiothreitol; Epinephrine; Female; Fructosephosphates; | 1973 |
The pancreatic beta-cell recognition of insulin secretagogues. Comparisons of glucose with glyceraldehyde isomers and dihydroxyacetone.
Topics: Acetone; Animals; Arginine; Calcium; Carbon Radioisotopes; Dinitrophenols; Epinephrine; Female; Gluc | 1974 |
[Lipolysis on isolated fat cells of obese mice].
Topics: Adenylyl Cyclases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; In Vitro Techniques; Mice; | 1968 |
[Control of ATP levels in stimulated pancreatic B-cells].
Topics: Adenosine Triphosphate; Animals; Butyrates; Carbutamide; Cyclic AMP; Diazoxide; Epinephrine; Glucago | 1969 |
An analysis of the lipolysis in vitro of obese-hyperglycaemic and diabetic mice.
Topics: Adenine Nucleotides; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Blood Glucose; Cyclic AMP | 1969 |
Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic mice.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Body Weight; Disease Models, Animal; Epididymi | 1970 |
Mobilization of fatty acids in genetically obese rats.
Topics: Adipose Tissue; Animals; Body Weight; Butyrates; Cyclic AMP; Epinephrine; Fasting; Fatty Acids, None | 1970 |
Regulation of pancreatic beta-cell glycogen through cyclic-3,5-AMP.
Topics: Adenine Nucleotides; Animals; Cyclic AMP; Epinephrine; Female; Glucagon; Glucose; Glycogen; Hypergly | 1971 |
Lipolysis and glucose tolerance in obese subjects during prolonged starvation.
Topics: Adipose Tissue; Adult; Blood Glucose; Body Height; Body Weight; Culture Techniques; Cyclic AMP; Diet | 1971 |
Effects of norepinephrine, theophylline and dibutyryl cyclic AMP on in vitro lipolysis of human adipose tissue in obesity.
Topics: Adipose Tissue; Adult; Aged; Body Weight; Cyclic AMP; Fatty Acids; Fatty Acids, Nonesterified; Femal | 1972 |
Lipolysis in the adipose tissue of mice made obese with goldthioglucose.
Topics: Adipose Tissue; Animals; Body Weight; Butyrates; Cell Count; Cyclic AMP; Epinephrine; Glucose; Gold; | 1972 |
Lipolysis and adenosine 3',5'-cyclic monophosphate in adipose tissue of the New Zealand obese mouse.
Topics: Adipose Tissue; Age Factors; Animals; Body Weight; Cyclic AMP; Glycerol; Isoproterenol; Lipid Metabo | 1973 |
Cell size and lipolysis by human subcutaneous adipose tissue.
Topics: Adipose Tissue; Adolescent; Adult; Biopsy; Body Weight; Cholecystectomy; Cyclic AMP; Female; Glycero | 1973 |
Lipolysis in genetically obese and diabetes-prone mice.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Blood Glucose; Body Weight; Butyrates; Cyclic AMP; Dieta | 1970 |
Evidence for decreased sensitivity to glucose of isolated islets from spiny mice. (Acomys cahirinus).
Topics: Animals; Antigens; Arginine; Cyclic AMP; Cytochalasin B; Diabetes Mellitus; Disease Models, Animal; | 1974 |
The preparation of, and studies on, free cell suspensions from mouse pancreatic islets.
Topics: Animals; Cell Count; Cell Separation; Cell Survival; Culture Media; Cytological Techniques; Cytoplas | 1974 |
[Six years' experience with a musculoplastic technic].
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists | 1971 |
Cyclic adenosine monophosphate in human adipose tissue.
Topics: Acetanilides; Adenylyl Cyclases; Adipose Tissue; Adrenal Glands; Adrenergic beta-Antagonists; Amino | 1972 |
B-pancreatic function in obese and diabetic children.
Topics: Arginine; Blood Glucose; Child; Diabetes Mellitus, Type 1; Ethylenediamines; Female; Glucagon; Gluco | 1972 |
The pancreatic -cell recognition of insulin secretagogues. V. Binding and stimulatory action of phlorizin.
Topics: Animals; Antimycin A; Arginine; Carbon Isotopes; Chloromercuribenzoates; Chlorpromazine; Diabetes Me | 1972 |
Dynamics of pancreatic beta-cell responses to glucose.
Topics: Adenosine Triphosphate; Animals; Culture Media; Fasting; Female; Fructosephosphates; Glucose; Glucos | 1973 |
Lipolysis of genetically obese and-or hyperglycemic mice with reference to insulin response of adipose tissue.
Topics: Adipose Tissue; Animals; Diabetes Mellitus; Epididymis; Epinephrine; Fatty Acids, Nonesterified; Gen | 1972 |
[Use of radionuclides in the study of the regional distribution of pulmonary perfusion and ventilation].
Topics: Acetylcholine; Age Factors; Ethylenediamines; Humans; Hypertension; Hypoxia; Lung; Lung Compliance; | 1971 |
[On the treatment of hyperlipemia with theophylline nicotinate].
Topics: Aged; Arteriosclerosis; Cerebrovascular Disorders; Coronary Disease; Embolism; Humans; Hyperlipidemi | 1969 |
Lipolysis and lipogenesis from glucose in human fat cells of different sizes. Effects of insulin, epinephrine, and theophylline.
Topics: Adipose Tissue; Adult; Age Factors; Aged; Epinephrine; Fatty Acids; Female; Glucose; Glycerides; Gly | 1970 |
[Importance of the association of a salidiuretic and a theophylline derivative in the treatment of obesity with respiratory insufficiency].
Topics: Humans; Hydrochlorothiazide; Obesity; Respiratory Insufficiency; Theophylline | 1965 |