theophylline has been researched along with Muscle Relaxation in 174 studies
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
Excerpt | Relevance | Reference |
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" The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit." | 7.69 | Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994) |
"Melatonin treatment strengthened contraction responses, but did not affect relaxation responses in rat tracheal preparations." | 5.38 | The achilles heel in melatonin: asthma. ( Belgin Yildirim, F; Karasu-Minareci, E; Kaya, Y, 2012) |
"Adenosine pretreatment (3." | 5.27 | Cellular Ca2+ monitored by aequorin in adenosine-mediated smooth muscle relaxation. ( Bradley, AB; Morgan, KG, 1985) |
"inhaled magnesium sulphate in acute asthma was shown to improve lung function measures (one trial, 60 women); intravenous theophylline in acute asthma was not associated with benefits (one trial, 65 women)." | 4.90 | Interventions for managing asthma in pregnancy. ( Bain, E; Clifton, VL; Crowther, CA; Hodyl, NA; Middleton, P; Pierides, KL; Stark, MJ, 2014) |
"Theophylline is a drug commonly used to treat asthma due to its anti-inflammatory and bronchodilatory properties." | 4.31 | Theophylline-Induced Relaxation Is Enhanced after Testosterone Treatment via Increased K ( Carbajal-García, A; Casas-Hernández, MF; Díaz-Hernández, V; Montaño, LM; Reyes-García, J; Sommer, B, 2023) |
" The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit." | 3.69 | Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994) |
" When compounds were intraduodenally administered to the guinea pig, 1-(2'-ethoxyethyl)-, 1-(3'-methoxypropyl)-, 1-(3'-butenyl)-, and 1-[(dimethylamino)-ethyl]-3-propylxanthines, 1-methyl-7-(2'-oxopropyl)-3-propylxanthine, and denbufylline (1,3-di-n-butyl-7-(2'-oxopropyl)xanthine) effectively inhibited the acetylcholine-induced bronchospasm without heart stimulation or central nervous system-stimulation at the effective dosage range." | 3.68 | Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. ( Hasegawa, T; Iwasaki, N; Konno, K; Kurita, M; Miyamoto, K; Ohshima, T; Sakai, R; Sanae, F; Takagi, K; Yamamoto, Y, 1993) |
" The rate and amplitude of smooth muscle relaxation at low PO2 were significantly decreased by tolbutamide (5 mmol l-1), which is known to inhibit cyclic AMP-dependent protein kinases." | 3.68 | Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats. ( Basilyuk, OV; Soloviev, AI, 1993) |
"We examined the effects of theophylline on contractile properties and high-frequency fatigue of canine diaphragm in vitro." | 3.68 | Theophylline minimally alters contractile properties of canine diaphragm in vitro. ( De Bock, V; Decramer, M; Derom, E; Janssens, S, 1990) |
" The autoradiographic distribution of alpha 1-adrenoceptors was investigated in non-diseased and asthmatic human lung by use of [3H]-prazosin (H-PZ)." | 3.67 | Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung. ( Goldie, RG; Paterson, JW; Rigby, PJ; Spina, D, 1989) |
"Melatonin treatment strengthened contraction responses, but did not affect relaxation responses in rat tracheal preparations." | 1.38 | The achilles heel in melatonin: asthma. ( Belgin Yildirim, F; Karasu-Minareci, E; Kaya, Y, 2012) |
"This study investigates the effect of theophylline along the rabbit gastrointestinal tract in comparison with the pharmacodynamic effect produced by the combined application of its three major metabolites." | 1.36 | The gastrointestinal effects that may follow the administration of theophylline reflect the pharmacodynamic profiles of both the parent drug and its metabolites. ( Batzias, GC; Koutsoviti-Papadopoulou, M; Peeters, TL; Psarra, TA, 2010) |
" The here obtained pharmacodynamic profiles of the drugs suggest that both milrinone and theophylline may be considered as potent relaxing agents of the lower oesophageal sphincter." | 1.35 | Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit. ( Batzias, GC; Koutsoviti-Papadopoulou, M; Psarra, TA, 2009) |
" Among them, 3,4-dipropyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-i]-purin-5-one (1c), which was the most selective and potent PDE IV inhibitor, did not cause emesis in Suncus murinus at a dosage range of 10-100 mg/kg (po), while an imidazole analogue of 1c (4c) and known PDE IV inhibitors such as rolipram and denbufylline caused emesis even at 10 or 30 mg/kg." | 1.30 | Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines. ( Kasugai, S; Miyamoto, K; Ohya, K; Sawanishi, H; Suzuki, H; Suzuki, N; Takagi, K; Waki, Y; Yamamoto, S, 1997) |
"Pretreatment with verapamil (1 or 10 microM), nifedipine (0." | 1.29 | The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine. ( Cortijo, J; Morcillo, EJ; Sanz, CM; Small, RC; Villagrasa, V, 1994) |
" The nitric oxide (NO) synthase inhibitor, L-monomethyl-L-arginine (30 microM) shifted the dose-response curve for NECA to the right in all groups suggesting that the vascular response to NECA is partially mediated through the release of NO." | 1.29 | Influence of aortic baroreceptor denervation on adenosine receptor-mediated relaxation of isolated rat aorta. ( Abdel-Rahman, AA; el-Mas, MM; Fahim, M; Mustafa, SJ, 1994) |
" Dose-response data for both agonists were best represented by two-site models." | 1.29 | A biphasic response to adenosine in the coronary vasculature of the K(+)-arrested perfused rat heart. ( Harden, FA; Harrison, GJ; Headrick, J; Jordan, LR; Willis, RJ, 1996) |
" Compound MV 8612 (8 and 16 microM) and MV 8610 (12 and 24 microM) caused a graded rightward displacement of BK dose-response curves in the isolated guinea pig trachea (dose ratio 2- to 4-fold)." | 1.28 | Effect of compounds from Mandevilla velutina on bradykinin-mediated contractile and relaxant responses of the isolated guinea pig trachea. ( Calixto, JB; Cruz, AB; Medeiros, YS; Yunes, RA, 1992) |
"Cromakalim (BRL 34915) is a potassium channel opener with therapeutic potential as a bronchodilator in asthma." | 1.28 | The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle. ( Cortijo, J; Morcillo, E; Paris, F; Pedrós, C; Perpiñá, M; Sarriá, B, 1992) |
"Adenosine analogs were tested for their ability to relax carbachol-contracted trachea in vitro." | 1.28 | Relaxant effects of adenosine analogs on guinea pig trachea in vitro: xanthine-sensitive and xanthine-insensitive mechanisms. ( Brackett, LE; Daly, JW, 1991) |
"Theophylline was markedly less potent than any of the other agents." | 1.28 | Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig. ( Cowlrick, IS; Paciorek, PM; Perkins, RS; Taylor, JC; Waterfall, JF; Wilkinson, GF, 1990) |
"Since terbutaline treatment in premature labor has been shown to increase phosphodiesterase activity in the myometrium, the phosphodiesterase-inhibiting effect of theophylline and papaverine on myometrial preparations from pregnant women has been studied." | 1.27 | In vitro study of phosphodiesterase-inhibiting drugs: a complement to beta-sympathomimetic drug therapy in premature labor? ( Andersson, RG; Berg, G; Rydén, G, 1983) |
"2 Pretreatment with theophylline (25-50 microM) had no significant effect on the concentration-response curves obtained with either purine compound." | 1.27 | Purine receptors in the guinea-pig internal anal sphincter. ( Crema, A; Frigo, GM; Lecchini, S; Manzo, L; Onori, L; Tonini, M, 1983) |
"Enprofylline was more potent than theophylline in relaxing the egg albumin- or SRS-A-induced tracheal muscle tone." | 1.27 | Potent bronchodilating effects of enprofylline and theophylline on contractions induced by egg albumin or by slow reacting substance (SRS). ( Andersson, RG; Hedman, SE, 1984) |
"Papaverine was shown to be the substance able to cause the biggest relaxation effect." | 1.27 | Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study. ( Barbanti, G; Beneforti, P; Lapini, A; Turini, D, 1988) |
" We evaluated their relaxant effects on tracheal smooth muscle isolated from guinea pigs and pharmacokinetic characteristics in rats using 1,3-dimethylxanthine (theophylline, TPH) as the reference drug." | 1.27 | Studies on alkyl-xanthine derivatives. II. Pharmacokinetic and pharmacodynamic studies of a new bronchodilator, 1-methyl-3-propylxanthine (MPX). ( Hasegawa, T; Kuzuya, T; Miyamoto, K; Nadai, M; Ogawa, K; Ruttikorn, A; Takagi, K, 1988) |
"Theophylline was less potent in relaxing the potassium induced contraction." | 1.27 | Effects of theophylline on small human placental arteries in vitro. ( Nielsen-Kudsk, JE, 1985) |
"Adenosine pretreatment (3." | 1.27 | Cellular Ca2+ monitored by aequorin in adenosine-mediated smooth muscle relaxation. ( Bradley, AB; Morgan, KG, 1985) |
"5 Indomethacin treatment reversed the isoprenaline desensitization induced by chronic treatment (0." | 1.26 | Tolerance of guinea-pig airway muscle preparations to relaxant agonists induced by chronic exposure to isoprenaline in vivo. ( Brink, C, 1981) |
"Proxyphylline was excreted in urine both an unchanged compound (12." | 1.26 | Human metabolism of 7-substituted theophyllines: N3-demethylation and lack of oxidation of proxyphylline. ( Garcia, I; Segura, J; Tarrus, E, 1981) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 70 (40.23) | 18.7374 |
1990's | 75 (43.10) | 18.2507 |
2000's | 16 (9.20) | 29.6817 |
2010's | 12 (6.90) | 24.3611 |
2020's | 1 (0.57) | 2.80 |
Authors | Studies |
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Suzuki, F | 1 |
Kuroda, T | 1 |
Kawakita, T | 1 |
Manabe, H | 1 |
Kitamura, S | 1 |
Ohmori, K | 1 |
Ichimura, M | 1 |
Kase, H | 1 |
Ichikawa, S | 1 |
Millen, J | 1 |
Riley, TN | 1 |
Waters, IW | 1 |
Hamrick, ME | 1 |
Miyamoto, K | 4 |
Yamamoto, Y | 1 |
Kurita, M | 2 |
Sakai, R | 2 |
Konno, K | 1 |
Sanae, F | 2 |
Ohshima, T | 1 |
Takagi, K | 4 |
Hasegawa, T | 2 |
Iwasaki, N | 1 |
Sawanishi, H | 1 |
Suzuki, H | 2 |
Yamamoto, S | 1 |
Waki, Y | 1 |
Kasugai, S | 1 |
Ohya, K | 1 |
Suzuki, N | 1 |
Ríos-Santamarina, I | 1 |
García-Domenech, R | 1 |
Gálvez, J | 1 |
Cortijo, J | 4 |
Santamaria, P | 1 |
Morcillo, E | 2 |
Campillo, N | 1 |
García, C | 1 |
Goya, P | 1 |
Alkorta, I | 1 |
Páez, JA | 1 |
Reyes-García, J | 1 |
Díaz-Hernández, V | 1 |
Carbajal-García, A | 1 |
Casas-Hernández, MF | 1 |
Sommer, B | 1 |
Montaño, LM | 1 |
Emami, B | 1 |
Shakeri, F | 1 |
Ghorani, V | 1 |
Boskabady, MH | 8 |
Patai, Z | 1 |
Guttman, A | 1 |
Mikus, EG | 1 |
Keyhanmanesh, R | 2 |
Saadatloo, MA | 1 |
Boskabady, M | 1 |
Bain, E | 1 |
Pierides, KL | 1 |
Clifton, VL | 1 |
Hodyl, NA | 1 |
Stark, MJ | 1 |
Crowther, CA | 1 |
Middleton, P | 1 |
Yuzkat, N | 1 |
Kati, I | 1 |
Isik, Y | 1 |
Kavak, S | 1 |
Goktas, U | 1 |
Cengiz, N | 1 |
Psarra, TA | 3 |
Batzias, GC | 3 |
Peeters, TL | 2 |
Koutsoviti-Papadopoulou, M | 3 |
Bozarov, A | 1 |
Wang, YZ | 1 |
Yu, JG | 1 |
Wunderlich, J | 1 |
Hassanain, HH | 1 |
Alhaj, M | 1 |
Cooke, HJ | 1 |
Grants, I | 1 |
Ren, T | 1 |
Christofi, FL | 1 |
Zhang, Y | 2 |
Miller, DV | 1 |
Paterson, WG | 1 |
Aronsson, P | 1 |
Andersson, M | 1 |
Ericsson, T | 1 |
Giglio, D | 2 |
Ozolua, RI | 1 |
Adejayan, A | 1 |
Aigbe, OP | 1 |
Uwaya, DO | 1 |
Argawal, A | 1 |
Tazzeo, T | 1 |
Bates, G | 1 |
Roman, HN | 1 |
Lauzon, AM | 1 |
Khasnis, MD | 1 |
Eto, M | 1 |
Janssen, LJ | 1 |
Karasu-Minareci, E | 1 |
Kaya, Y | 1 |
Belgin Yildirim, F | 1 |
Tasatargil, A | 1 |
Sadan, G | 4 |
Ozdem, SS | 1 |
Jandaghi, P | 1 |
Ramazani, M | 1 |
Tabei, T | 1 |
Usta, C | 2 |
Tuncel, B | 1 |
Delbro, DS | 1 |
Tobin, G | 1 |
Aslani, MR | 2 |
Kiani, S | 2 |
Rakhshandah, H | 1 |
Karlsson, JA | 3 |
Persson, CG | 3 |
Middleton, E | 1 |
Bergstrand, H | 1 |
Ishikawa, Y | 1 |
Takahashi, T | 2 |
Yamamura, T | 2 |
Rohner, TJ | 1 |
Hannigan, J | 1 |
Webb, RC | 1 |
Bohr, DF | 1 |
Brink, C | 2 |
Polson, JB | 3 |
Krzanowski, JJ | 3 |
Szentivanyi, A | 3 |
Berg, G | 2 |
Andersson, RG | 3 |
Rydén, G | 2 |
Crema, A | 1 |
Frigo, GM | 1 |
Lecchini, S | 1 |
Manzo, L | 1 |
Onori, L | 1 |
Tonini, M | 1 |
Mehta, AK | 1 |
Kulkarni, SK | 1 |
Kukovetz, WR | 1 |
Pöch, G | 1 |
Holzmann, S | 1 |
Collis, MG | 4 |
Brown, CM | 1 |
Darius, H | 1 |
Weiss, P | 1 |
Schrör, K | 1 |
Satchell, D | 1 |
Smith, R | 1 |
Hedman, SE | 1 |
Zuskin, E | 2 |
Duncan, PG | 2 |
Douglas, JS | 2 |
Barron, JT | 1 |
Bárány, M | 1 |
Bárány, K | 1 |
Storti, RV | 1 |
Tarrus, E | 1 |
Garcia, I | 1 |
Segura, J | 1 |
Norris, AA | 1 |
Eyre, P | 1 |
Gordon, VP | 1 |
Kimura, I | 1 |
Kimura, M | 1 |
Yoshimura, Y | 1 |
Muramatsu, I | 1 |
Fujiwara, M | 1 |
Miura, A | 1 |
Shibata, S | 3 |
Chevillard, C | 1 |
Saiag, B | 1 |
Worcel, M | 1 |
Vials, AJ | 2 |
Burnstock, G | 3 |
Hussain, T | 1 |
Leigh, JH | 1 |
Mustafa, SJ | 5 |
Prentice, DJ | 3 |
Shankley, NP | 1 |
Black, JW | 1 |
Mellemkjaer, S | 2 |
Nielsen-Kudsk, JE | 4 |
Tsunoda, R | 1 |
Okumura, K | 1 |
Ishizaka, H | 1 |
Matsunaga, T | 1 |
Tabuchi, T | 1 |
Yasue, H | 1 |
Akaike, T | 1 |
Sato, K | 1 |
Maeda, H | 1 |
Lewis, CD | 1 |
Hourani, SM | 6 |
Long, CJ | 1 |
Lin, CI | 1 |
Wu, SL | 1 |
Tao, PL | 1 |
Chen, HM | 1 |
Wei, J | 1 |
Martin, PL | 1 |
Potts, AA | 1 |
Wakusawa, S | 1 |
Jiang, C | 1 |
Collins, P | 1 |
Sanz, CM | 1 |
Villagrasa, V | 1 |
Morcillo, EJ | 1 |
Small, RC | 6 |
Kokubun, S | 1 |
Vuorinen, P | 1 |
Wu, X | 1 |
Arvola, P | 1 |
Vapaatalo, H | 1 |
Pörsti, I | 1 |
Boland, B | 1 |
Himpens, B | 1 |
Paques, C | 1 |
Casteels, R | 1 |
Gillis, JM | 1 |
Iwamoto, T | 1 |
Umemura, S | 1 |
Toya, Y | 1 |
Uchibori, T | 1 |
Kogi, K | 1 |
Takagi, N | 1 |
Ishii, M | 1 |
Najbar, A | 1 |
Li, CG | 1 |
Rand, MJ | 1 |
Sarriá, B | 2 |
Naline, E | 2 |
Brisac, AM | 1 |
Laurent, S | 1 |
Advenier, C | 4 |
Fahim, M | 1 |
el-Mas, MM | 1 |
Abdel-Rahman, AA | 1 |
Vials, A | 1 |
Fedan, JS | 1 |
Belt, JJ | 1 |
Yuan, LX | 1 |
Frazer, DG | 1 |
Soloviev, AI | 1 |
Basilyuk, OV | 1 |
Lin, CH | 1 |
Ko, FN | 1 |
Wu, YC | 1 |
Lu, ST | 1 |
Teng, CM | 1 |
Michel, A | 1 |
Laurent, F | 1 |
Chapat, JP | 1 |
Boucard, M | 1 |
Bonnet, PA | 1 |
Souccar, C | 1 |
Gonçalo, Mdo C | 1 |
Lapa, AJ | 1 |
Troncone, LR | 1 |
Lebrun, I | 1 |
Magnoli, F | 1 |
Nicholls, J | 2 |
Brownhill, VR | 1 |
Harden, FA | 1 |
Harrison, GJ | 1 |
Headrick, J | 1 |
Jordan, LR | 1 |
Willis, RJ | 1 |
Piper, AS | 1 |
Hollingsworth, M | 2 |
Planquois, JM | 1 |
Ruffin-Morin, Y | 1 |
Lagente, V | 1 |
Payne, AN | 1 |
Dahl, SG | 1 |
Kaputlu, I | 1 |
Yoshihara, S | 1 |
Lindén, A | 1 |
Kashimoto, K | 1 |
Nagano, Y | 1 |
Ichimura, T | 1 |
Nadel, JA | 1 |
Broadley, KJ | 1 |
Maddock, HL | 1 |
Thirstrup, S | 1 |
Nielsen-Kudsk, F | 1 |
Dahl, R | 1 |
Rubinstein, R | 1 |
Shalev, M | 1 |
Nissenkorn, I | 1 |
Cohen, S | 1 |
Hernández, M | 1 |
Barahona, MV | 1 |
Bustamante, S | 1 |
García-Sacristán, A | 1 |
Orensanz, LM | 1 |
Satake, N | 2 |
Imanishi, M | 1 |
Bültmann, R | 2 |
Starke, K | 2 |
Fayon, MJ | 1 |
Denis, D | 1 |
Molimard, M | 1 |
Berger, P | 1 |
Choukroun, ML | 1 |
Demarquez, JL | 1 |
Marthan, R | 1 |
Clevel, H | 1 |
Lachaud, JL | 1 |
Martinez, B | 1 |
Téchoueyres, P | 1 |
Klebroff, W | 1 |
Lefebvre, RA | 1 |
Willems, JL | 1 |
Anderson, WH | 1 |
Fitzpatrick, DF | 1 |
Hwang, DP | 1 |
Gerritsen, ME | 1 |
Mathison, R | 1 |
Lederis, K | 1 |
Lohmann, SM | 1 |
Miech, RP | 1 |
Butcher, FR | 1 |
Johansson, SR | 1 |
Anderson, RG | 1 |
Kolbeck, RC | 1 |
Speir, WA | 1 |
Carrier, GO | 1 |
Bransome, ED | 1 |
Fredholm, BB | 1 |
Brodin, K | 1 |
Strandberg, K | 1 |
Baer, HP | 1 |
Frew, R | 1 |
Ueda, S | 1 |
Ikegami, K | 1 |
Sakanashi, M | 1 |
Yonemura, KI | 1 |
Okwuasaba, FK | 1 |
Hamilton, JT | 1 |
Cook, MA | 1 |
Cambar, J | 1 |
Saurel, J | 1 |
Canellas, J | 1 |
Pfaffman, MA | 1 |
McFarland, SA | 1 |
Filbert, MG | 1 |
Moore, DH | 1 |
Adler, M | 1 |
Jenne, JW | 1 |
Yeoh, HC | 1 |
Shaughnessy, TK | 1 |
Hur, K | 1 |
Miura, M | 1 |
Belvisi, MG | 1 |
Stretton, CD | 1 |
Yacoub, MH | 1 |
Barnes, PJ | 1 |
Calixto, JB | 1 |
Yunes, RA | 1 |
Cruz, AB | 1 |
Medeiros, YS | 1 |
Berry, JL | 3 |
Foster, RW | 4 |
Hughes, SJ | 1 |
Smith, RD | 1 |
Miller, AJ | 1 |
Edwards, G | 1 |
Weston, AH | 1 |
Pedrós, C | 1 |
Perpiñá, M | 1 |
Paris, F | 1 |
Chinellato, A | 1 |
Ragazzi, E | 2 |
Pandolfo, L | 1 |
Froldi, G | 2 |
Caparrotta, L | 1 |
Fassina, G | 2 |
Koga, T | 1 |
Takata, Y | 1 |
Kobayashi, K | 1 |
Fujii, K | 1 |
Nagao, T | 1 |
Fujishima, M | 1 |
Nielsen, CB | 1 |
Postorino, A | 2 |
Serio, R | 2 |
Mulè, F | 2 |
Rinkema, LE | 1 |
Roman, CR | 1 |
Russell, WL | 1 |
Spaethe, SM | 1 |
Bemis, KG | 1 |
Henry, DP | 1 |
Marshall, WS | 1 |
Fleisch, JH | 1 |
Murray, MA | 1 |
Cook, SJ | 1 |
Green, KA | 1 |
Ingvast-Larsson, C | 1 |
Yang, JN | 1 |
Mitzner, W | 1 |
Hirshman, C | 1 |
Bailey, SJ | 1 |
Kitchen, I | 1 |
Takahashi, Y | 1 |
Ishii, N | 1 |
Lue, TF | 1 |
Tanagho, EA | 1 |
Mehta, PN | 1 |
Panitch, HB | 1 |
Wolfson, MR | 1 |
Shaffer, TH | 1 |
Labat, C | 1 |
Braunstein, G | 1 |
Devillier, P | 1 |
Blanc, M | 1 |
Gnassounou, JP | 1 |
Candenas, ML | 1 |
D'Ocón, MP | 1 |
Cortes, D | 1 |
Brackett, LE | 2 |
Daly, JW | 2 |
Sabouni, MH | 1 |
Brown, GL | 1 |
Kotake, AN | 1 |
Douglas, FL | 1 |
Bang, L | 1 |
Brønsgaard, AM | 1 |
Nikitina, EI | 1 |
Landsberg, KF | 1 |
Vaughan, LM | 1 |
Heffner, JE | 1 |
Derom, E | 1 |
Janssens, S | 1 |
De Bock, V | 1 |
Decramer, M | 1 |
Bai, TR | 1 |
Shamim, MT | 1 |
Paciorek, PM | 1 |
Cowlrick, IS | 1 |
Perkins, RS | 1 |
Taylor, JC | 1 |
Wilkinson, GF | 1 |
Waterfall, JF | 1 |
Rose'Meyer, RB | 1 |
Hope, W | 1 |
Finney, MJ | 1 |
Spina, D | 3 |
Rigby, PJ | 2 |
Paterson, JW | 3 |
Goldie, RG | 3 |
Boyle, JP | 2 |
Duty, S | 1 |
Elliott, KR | 2 |
Watt, AJ | 2 |
Wu, CC | 1 |
Chiou, WF | 1 |
Yen, MH | 1 |
Furukawa, K | 1 |
Nomoto, T | 1 |
Stoggall, SM | 1 |
Martin, FM | 1 |
Fernandes, LB | 1 |
Knight, DA | 1 |
Kantoh, M | 1 |
Kusunoki, M | 1 |
Utsunomiya, J | 1 |
Manzini, S | 1 |
Maggi, CA | 1 |
Meli, A | 1 |
Solov'ev, AI | 1 |
Nakagawa, Y | 1 |
Gudenzi, M | 1 |
Barbanti, G | 1 |
Beneforti, P | 1 |
Lapini, A | 1 |
Turini, D | 1 |
Gaion, RM | 2 |
Dorigo, P | 2 |
Trolese, B | 1 |
Borin, E | 1 |
Adami, R | 1 |
Gambarotto, L | 1 |
Santi Soncin, E | 1 |
Esau, SA | 1 |
Ruttikorn, A | 1 |
Nadai, M | 1 |
Kuzuya, T | 1 |
Ogawa, K | 1 |
Svedmyr, N | 1 |
Welford, LA | 1 |
Loizou, GD | 1 |
Cusak, NJ | 1 |
Ceroni, G | 1 |
Giacometti, A | 1 |
Valentini, E | 1 |
Maragno, I | 1 |
Achterrath-Tuckermann, U | 1 |
Szelenyi, I | 1 |
Urdaneta-Bohorquez, A | 1 |
Sakamoto, Y | 1 |
Carlsson, I | 1 |
Sollevi, A | 1 |
Wennmalm, A | 1 |
Nishida, Y | 1 |
Suzuki, S | 1 |
Miyamoto, T | 1 |
Askar, AO | 1 |
Palmer, DB | 1 |
Baxter, GS | 1 |
Bradley, AB | 1 |
Morgan, KG | 1 |
Savage, AO | 1 |
Atanga, GK | 1 |
4 reviews available for theophylline and Muscle Relaxation
Article | Year |
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Interventions for managing asthma in pregnancy.
Topics: Adrenal Cortex Hormones; Algorithms; Anti-Asthmatic Agents; Asthma; Beclomethasone; Female; Humans; | 2014 |
Airway smooth muscle, asthma, and calcium ions.
Topics: Asthma; Asthma, Exercise-Induced; Autacoids; Binding Sites; Calcium; Calcium Channel Blockers; Calmo | 1984 |
Phosphodiesterase inhibition and theophylline.
Topics: 1-Methyl-3-isobutylxanthine; Cromolyn Sodium; Histamine Release; Humans; Kinetics; Lung; Muscle Rela | 1980 |
Airway smooth muscle and disease workshop: theophylline.
Topics: Animals; Asthma; Bronchi; Bronchodilator Agents; Guinea Pigs; Humans; In Vitro Techniques; Muscle Re | 1987 |
1 trial available for theophylline and Muscle Relaxation
Article | Year |
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The effect of theophylline on respiratory muscle contractility and fatigue.
Topics: Animals; Diaphragm; Dogs; Double-Blind Method; Fatigue; Guinea Pigs; Humans; Lung Diseases, Obstruct | 1990 |
169 other studies available for theophylline and Muscle Relaxation
Article | Year |
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New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones.
Topics: Animals; Bronchodilator Agents; Drug Interactions; Guinea Pigs; Imidazoles; Male; Mice; Muscle Relax | 1992 |
2-(beta-Arylethylamino)- and 4-(beta-arylethylamino)quinazolines as phosphodiesterase inhibitors.
Topics: Animals; Cattle; Ethylamines; Female; Guinea Pigs; Muscle Relaxation; Muscle, Smooth; Myocardium; Ph | 1985 |
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.
Topics: Administration, Oral; Animals; Bronchial Spasm; Bronchodilator Agents; Guinea Pigs; Heart Rate; Male | 1993 |
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiester | 1997 |
New bronchodilators selected by molecular topology.
Topics: Animals; Bronchodilator Agents; Discriminant Analysis; Female; Guinea Pigs; In Vitro Techniques; Mal | 1998 |
Novel bronchodilators: synthesis, transamination reactions, and pharmacology of a series of pyrazino[2,3-c][1,2,6]thiadiazine 2, 2-dioxides.
Topics: Animals; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Lethal Dose 50; Magnetic Resonance | 2000 |
Theophylline-Induced Relaxation Is Enhanced after Testosterone Treatment via Increased K
Topics: Animals; Asthma; Female; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Sexual Maturation; Te | 2023 |
Relaxant effect of Curcuma longa on rat tracheal smooth muscle and its possible mechanisms.
Topics: Animals; Bronchodilator Agents; Curcuma; Dose-Response Relationship, Drug; Ethanol; Male; Methacholi | 2017 |
Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smoo | 2018 |
Contribution of water and lipid soluble substances in the relaxant effects of Tymus vulgaris extract on guinea pig tracheal smooth muscle in vitro.
Topics: Animals; Bronchodilator Agents; Guinea Pigs; In Vitro Techniques; Lamiaceae; Lipids; Muscle Relaxati | 2016 |
Effects of Theophylline with Methylprednisolone Combination Therapy on Biomechanics and Histopathology in Diaphragm Muscles of Rats.
Topics: Animals; Biomechanical Phenomena; Diaphragm; Drug Synergism; Drug Therapy, Combination; Methylpredni | 2016 |
Relaxing and contracting effects of theophylline's metabolites on the rabbit upper gastrointestinal tract.
Topics: Animals; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Muscle Contraction; Mu | 2008 |
Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit.
Topics: Animals; Bronchodilator Agents; Esophageal Sphincter, Lower; Female; Male; Milrinone; Muscle Relaxat | 2009 |
The gastrointestinal effects that may follow the administration of theophylline reflect the pharmacodynamic profiles of both the parent drug and its metabolites.
Topics: Acetylcholine; Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Gastrointes | 2010 |
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relation | 2009 |
TREK-1 channels do not mediate nitrergic neurotransmission in circular smooth muscle from the lower oesophageal sphincter.
Topics: Animals; Calcium; Colon; Esophageal Sphincter, Lower; Female; In Vitro Techniques; Male; Membrane Po | 2010 |
Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Drug Antagonism; Electr | 2010 |
Some characteristic relaxant effects of aqueous leaf extract of Andrographis paniculata and andrographolide on guinea pig tracheal rings.
Topics: Andrographis; Animals; Calcium; Carbachol; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hi | 2011 |
Caffeine relaxes smooth muscle through actin depolymerization.
Topics: Actins; Animals; Biopolymers; Caffeine; Cattle; Enzyme Assays; Humans; In Vitro Techniques; Indoles; | 2012 |
Relaxant effects of different fractions from Tymus vulgaris on guinea-pig tracheal chains.
Topics: Animals; Bronchodilator Agents; Female; Guinea Pigs; Hexanes; Male; Methanol; Methylene Chloride; Mu | 2012 |
The achilles heel in melatonin: asthma.
Topics: Acetylcholine; Animals; Asthma; Circadian Rhythm; Dose-Response Relationship, Drug; Injections, Intr | 2012 |
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Argini | 2003 |
Relaxant effects of carvacrol on guinea pig tracheal chains and its possible mechanisms.
Topics: Animals; Bronchoconstrictor Agents; Bronchodilator Agents; Central Nervous System Depressants; Cymen | 2003 |
Relaxant effects of different fractions of essential oil from Carum copticum on guinea pig tracheal chains.
Topics: Animals; Bronchodilator Agents; Carum; Chlorpheniramine; Dose-Response Relationship, Drug; Ethanol; | 2003 |
The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Guinea Pigs; Histamine; In Vitro Techniques; Indom | 2004 |
Postjunctional modulation by muscarinic M2 receptors of responses to electrical field stimulation of rat detrusor muscle preparations.
Topics: Animals; Diamines; Electric Stimulation; In Vitro Techniques; Muscarinic Antagonists; Muscle Contrac | 2005 |
Relaxant effect of Thymus vulgaris on guinea-pig tracheal chains and its possible mechanism(s).
Topics: Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Guinea Pigs; Male; Methacholine Ch | 2006 |
Relaxant effects of Rosa damascena on guinea pig tracheal chains and its possible mechanism(s).
Topics: Animals; Bronchi; Bronchodilator Agents; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle | 2006 |
Relaxant effect of Crocus sativus (saffron) on guinea-pig tracheal chains and its possible mechanisms.
Topics: Animals; Bronchi; Bronchodilator Agents; Carotenoids; Crocus; Cyclohexenes; Dose-Response Relationsh | 2006 |
Neither vasoactive intestinal peptide (VIP) nor purine derivatives may mediate non-adrenergic tracheal inhibition.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Atropine; Carbachol; Electric Stimulation; Fema | 1984 |
[Action of adenosine 5'-triphosphate and effects of various purinergic receptor blocking agents on the movements of an isolated guinea pig gallbladder].
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Apamin; Atropine; Female; Gallbladder; | 1983 |
Effect of norepinephrine and isoproterenol on in vitro detrusor muscle contractility and cyclic AMP content.
Topics: Animals; Cyclic AMP; Dogs; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Mus | 1980 |
Relaxation of vascular smooth muscle by isoproterenol, dibutyryl-cyclic AMP and theophylline.
Topics: Animals; Arteries; Bucladesine; Cats; Dogs; Female; In Vitro Techniques; Isoproterenol; Male; Muscle | 1981 |
Tolerance of guinea-pig airway muscle preparations to relaxant agonists induced by chronic exposure to isoprenaline in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Female; Guinea Pigs; Histamine; In Vitro | 1981 |
Inhibition of a high affinity cyclic AMP phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Dogs; Etazolate; Female; Male; M | 1982 |
In vitro study of phosphodiesterase-inhibiting drugs: a complement to beta-sympathomimetic drug therapy in premature labor?
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Drug Interactions; Female; Humans; Muscle Relaxation; My | 1983 |
Purine receptors in the guinea-pig internal anal sphincter.
Topics: Adenosine; Adenosine Triphosphate; Anal Canal; Animals; Dose-Response Relationship, Drug; Female; Gu | 1983 |
Evidence for the presence of P1- and P2-purinoceptors in rat caecum.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Caffeine; Cecum; Cyclic AMP; Female; | 1983 |
Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Aminophylline; Animals; Cattle; Drug Synergi | 1983 |
Adenosine relaxes the aorta by interacting with an A2 receptor and an intracellular site.
Topics: Adenosine; Animals; Aorta; Dipyridamole; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques | 1983 |
Stereospecific stimulation of coronary vascular PGI2 by organic nitrates--studies with the new compound teopranitol (KC-046).
Topics: Animals; Caffeine; Cattle; Coronary Vessels; Epoprostenol; In Vitro Techniques; Muscle Relaxation; N | 1984 |
Adenosine causes contractions in spiral strips and relaxations in transverse strips of guinea-pig trachea: studies on mechanism of action.
Topics: Adenosine; Adenosine Triphosphate; Animals; Dipyridamole; Female; Guinea Pigs; In Vitro Techniques; | 1984 |
Potent bronchodilating effects of enprofylline and theophylline on contractions induced by egg albumin or by slow reacting substance (SRS).
Topics: Adenosine Deaminase; Albumins; Animals; Bronchi; Female; Guinea Pigs; Male; Muscle Contraction; Musc | 1984 |
The pharmacological characterization of aqueous extracts of vegetable dusts.
Topics: Animals; Caffeine; Coffee; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Rela | 1983 |
Reversible phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin during the contraction-relaxation-contraction cycle of arterial smooth muscle.
Topics: Animals; Calcium; Carotid Arteries; Chlorpromazine; Egtazic Acid; Muscle Contraction; Muscle Relaxat | 1980 |
Pharmacological characterisation of extracts of coffee dusts.
Topics: Animals; Coffee; Dose-Response Relationship, Drug; Dust; Female; Guinea Pigs; Histamine; In Vitro Te | 1983 |
Human metabolism of 7-substituted theophyllines: N3-demethylation and lack of oxidation of proxyphylline.
Topics: Aminophylline; Animals; Biotransformation; Dealkylation; Guinea Pigs; Humans; In Vitro Techniques; I | 1981 |
Effects of Freund's complete adjuvant and ovalbumin sensitization on the pharmacological reactivity of isolated guinea-pig trachea.
Topics: Animals; Carbachol; Freund's Adjuvant; Guinea Pigs; Histamine; Immunization; In Vitro Techniques; Is | 1982 |
Influence of tracheal contraction on relaxant effects in vitro of theophylline and isoprenaline.
Topics: Airway Resistance; Animals; Carbachol; Drug Interactions; Female; Guinea Pigs; Hydrogen-Ion Concentr | 1981 |
Quantitization of Ca spike frequency in a single sucrose gap and mechanical relaxation induced by Ca antagonists, isoproterenol and papaverine.
Topics: Action Potentials; Calcium; Calcium Channel Blockers; Humans; In Vitro Techniques; Isoproterenol; Ma | 1981 |
Reactivity of isolated canine cerebral arteries to adenine nucleotides and adenosine.
Topics: Adenine Nucleotides; Adenosine; Animals; Cerebral Arteries; Dogs; Female; In Vitro Techniques; Male; | 1980 |
Hydralazine: mode of action at the neuroarterial junction.
Topics: Animals; Arteries; Dose-Response Relationship, Drug; Hydralazine; Hypertension; In Vitro Techniques; | 1980 |
Differential effects of ATP- and 2-methylthioATP-induced relaxation in guinea pig coronary vasculature.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Coronary Vessels; Electrophysiology; Female; G | 1994 |
Regulation of adenosine receptor function by theophylline in rat aorta.
Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic beta-Agonists; Animals; Aort | 1994 |
Pharmacological analysis of the interaction between purinoceptor agonists and antagonists in the guinea-pig taenia caecum.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cecum; Dipyridamole; Do | 1995 |
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; | 1994 |
Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies.
Topics: Animals; Arginine; Benzoates; Blood Pressure; Coronary Circulation; Cyclic N-Oxides; Dogs; Dose-Resp | 1994 |
Characterization of adenosine receptors in the rat isolated aorta.
Topics: Adenosine; Animals; Aorta, Thoracic; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, V | 1994 |
The role of cyclic AMP and phosphodiesterase activity in the mechanism of action of tetramethylpyrazine on human and dog cardiac and dog coronary arterial tissues.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Coronary Vessels; Cyclic AMP; Dogs; | 1993 |
The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxamidoadenosine and N6-cyclopentyladenosine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine; Endothelium, Vascular; Glyburide; I | 1994 |
Cyclic nucleotide phosphodiesterase isoenzymes in guinea-pig tracheal muscle and bronchorelaxation by alkylxanthines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Agonists; Albuterol; Animals; Bronchodilator Ag | 1994 |
Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Capsaicin; Coronary Vessels; Endothelium, Vasc | 1994 |
The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine.
Topics: Animals; Caffeine; Calcium Chloride; Cold Temperature; Drug Interactions; Female; Guinea Pigs; Hista | 1994 |
Subtypes of purinoceptors in rat and dog urinary bladder smooth muscles.
Topics: Acetylcholine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Dogs; Female; In V | 1994 |
Effects of P1 and P2Y purinoceptor antagonists on endothelium-dependent and -independent relaxations of rat mesenteric artery to GTP and guanosine.
Topics: Adenosine; Adenosine Triphosphate; Animals; Endothelium, Vascular; Guanosine; Guanosine Triphosphate | 1994 |
ATP induced-relaxation in the mouse bladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Calcium; Cytosol; Electric Stimulation; Fura-2; In Vitro Techniques | 1993 |
Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells.
Topics: Acetylcholine; Adenosine; Alkynes; Animals; Antihypertensive Agents; Aorta; Aorta, Thoracic; Base Se | 1994 |
The effect of suramin on vasodilator responses to ATP and 2-methylthio-ATP in the Sprague-Dawley rat coronary vasculature.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Vessels; Drug Interactions; In Vitro Techniques | 1994 |
Pharmacological actions of the coenzymes NAD(H) and NADP(H) on the rat anococcygeus muscle.
Topics: Adenosine; Animals; Arginine; Electric Stimulation; Male; Muscle Contraction; Muscle Relaxation; NAD | 1994 |
The nicardipine-isoprenaline interaction in human and guinea-pig isolated airways.
Topics: Adenosine; Animals; Bronchi; Colforsin; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pig | 1994 |
Influence of aortic baroreceptor denervation on adenosine receptor-mediated relaxation of isolated rat aorta.
Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta, Thoracic; Arginine; Blo | 1994 |
A2-purinoceptor-mediated relaxation in the guinea-pig coronary vasculature: a role for nitric oxide.
Topics: Adenosine; Animals; Antihypertensive Agents; Arginine; Coronary Vessels; Female; Guinea Pigs; In Vit | 1993 |
Relaxant effects of nucleotides in guinea pig isolated, perfused trachea: lack of involvement of prostanoids, Cl- channels and adenosine.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 1993 |
Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats.
Topics: Actin Cytoskeleton; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Chlorides; Cy | 1993 |
The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens.
Topics: Alkaloids; Animals; Benzopyrans; Calcium; Calmodulin; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; | 1993 |
Pharmacological activities of imidazo[1,2-alpha]pyrazine derivatives.
Topics: Adenosine; Animals; Calcium; Cardiovascular Agents; Cattle; Diuresis; Guinea Pigs; Heart Atria; Hear | 1995 |
Blockade of acetylcholine release at the motor endplate by a polypeptide from the venom of Phoneutria nigriventer.
Topics: Acetylcholine; Animals; Chickens; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Endpl | 1995 |
Characterization of P1-purinoceptors on rat isolated duodenum longitudinal muscle and muscularis mucosae.
Topics: Adenosine; Animals; Duodenum; Male; Muscle Relaxation; Muscle, Smooth; Rats; Receptors, Purinergic P | 1996 |
A biphasic response to adenosine in the coronary vasculature of the K(+)-arrested perfused rat heart.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Coronary Vessels; Hea | 1996 |
Activation of multiple sites by adenosine analogues in the rat isolated aorta.
Topics: Adenosine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; | 1996 |
ATP and beta,gamma-methylene ATP produce relaxation of guinea-pig isolated trachealis muscle via actions at P1 purinoceptors.
Topics: Adenosine Triphosphate; Animals; Carbachol; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; | 1996 |
Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea pig isolated trachea.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Albuterol; Animals; Drug S | 1996 |
Evidence that nitric oxide mediates non-adrenergic non-cholinergic relaxation induced by GABA and electrical stimulation in the rat isolated duodenum.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; E | 1996 |
A novel PACAP 1-27 analogue causes sustained smooth muscle relaxation in guinea-pig trachea.
Topics: Albuterol; Animals; Bronchodilator Agents; Captopril; Glycopeptides; Guinea Pigs; In Vitro Technique | 1996 |
Adenosine analogues relax guinea-pig taenia caeci via an adenosine A2B receptor and a xanthine-resistant site.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cecum; Dose-Response Relationship, Drug; Guin | 1997 |
P1-purinoceptor-mediated vasodilatation and vasoconstriction in hypoxia.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Guinea Pigs; Hypoxia; In Vitro Techniques; In | 1996 |
In vitro studies on the interactions of beta2-adrenoceptor agonists, methylxanthines, Ca2+-channel blockers, K+-channel openers and other airway smooth muscle relaxants in isolated guinea-pig trachea.
Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Drug Interacti | 1997 |
Effect of exogenous adenosine and its monophosphate on the contractile response to acetylcholine in the human isolated detrusor muscle strips.
Topics: Acetylcholine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Adrenergic beta-Agonists; | 1998 |
A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission.
Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relatio | 1999 |
Increased nitroglycerin-induced relaxation by genistein in rat aortic rings.
Topics: Animals; Aorta; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; | 1999 |
The potentiating effect of genistein on the relaxation induced by isoproterenol in rat aortic rings.
Topics: Adrenergic beta-Agonists; Animals; Aorta; Benzoflavones; Bucladesine; Colforsin; Dose-Response Relat | 1999 |
Comparison of the effects of selective III, IV and nonselective phosphodiesterase inhibitors on isolated tracheal preparations in streptozotocin-diabetic rats.
Topics: Amrinone; Animals; Carbachol; Cardiotonic Agents; Diabetes Mellitus, Experimental; Dose-Response Rel | 2000 |
Nucleotide-evoked relaxation of rat vas deferens--a possible role for endogenous ATP released upon alpha(1)-adrenoceptor stimulation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apyrase; Dose-Response Relationship, Drug; I | 2001 |
Pharmacologically induced relaxation of tracheal smooth muscle is increased in hyperoxia-exposed 15-day-old rats.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Animals, Newborn; Hyperoxia; Muscle Relaxation; Muscle | 2002 |
Nucleotide-evoked relaxation of rat vas deferens: possible mechanisms.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Diphosphate; Adenosine Triphosp | 2002 |
Gastric relaxation by apomorphine and ATP in the conscious dog.
Topics: Adenosine Triphosphate; Animals; Apomorphine; Dogs; Female; Muscle Contraction; Muscle Relaxation; M | 1979 |
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1979 |
Urotensin I induced relaxation and intracellular cAMP content in the rat tail artery.
Topics: Animals; Arteries; Cyclic AMP; Drug Interactions; Fishes; In Vitro Techniques; Male; Muscle Contract | 1977 |
Effects of isoproterenol, theophylline and carbachol on cyclic nucleotide levels and relaxation of bovine tracheal smooth muscle.
Topics: Animals; Atropine; Carbachol; Cattle; Dose-Response Relationship, Drug; Isoproterenol; Muscle Relaxa | 1977 |
Effects of isoprenaline on the time course of the cyclic AMP level in rat uterus.
Topics: Adenosine; Animals; Catechols; Corticosterone; Cyclic AMP; Dipyridamole; Female; Guanosine Triphosph | 1978 |
Apparent irrelevance of cyclic nucleotides to the relaxation of tracheal smooth muscle induced by theophylline.
Topics: Animals; Calcium; Cyclic AMP; Cyclic GMP; Dogs; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxa | 1979 |
On the mechanism of relaxation of tracheal muscle by theophylline and other cyclic nucleotide phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cyclic AMP; Cyclic GMP; Drug Interactions; | 1979 |
Relaxation of guinea-pig fundic strip by adenosine, adenosine triphosphate and electrical stimulation: lack of antagonism by theophylline or ATP treatment.
Topics: Adenosine; Adenosine Triphosphate; Animals; Electric Stimulation; Female; Guinea Pigs; In Vitro Tech | 1979 |
Effects of prostaglandin E1 on isolated dog renal artery.
Topics: Animals; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isoproteren | 1979 |
Relaxations of guinea-pig fundic strip by adenosine, adenine nucleotides and electrical stimulation: antagonsism by theophylline and desensitization to adenosine and its derivatives.
Topics: Adenine Nucleotides; Adenosine; Animals; Electric Stimulation; In Vitro Techniques; Male; Muscle Con | 1977 |
The myorelaxant effect of theophylline on smooth muscle cells of the afferent arterioles and glomerular tuft.
Topics: Animals; Arterioles; In Vitro Techniques; Kidney Glomerulus; Male; Muscle Contraction; Muscle Relaxa | 1978 |
Relationship between theophylline-induced relaxation and excitation-contraction coupling in intestinal smooth muscle.
Topics: Action Potentials; Animals; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle R | 1978 |
Relaxation of soman-induced contracture of airway smooth muscle in vitro.
Topics: Acetylcholine; Adrenergic beta-Agonists; Albuterol; Animals; Colforsin; Dogs; Dose-Response Relation | 1992 |
Theophylline produces over-additive relaxation of canine tracheal smooth muscle when combined with beta-agonists: the dose-response relationship.
Topics: Adrenergic beta-Agonists; Animals; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Epitheliu | 1992 |
Role of potassium channels in bronchodilator responses in human airways.
Topics: Adolescent; Adult; Apamin; Benzopyrans; Bronchi; Bronchodilator Agents; Charybdotoxin; Child; Cromak | 1992 |
Effect of compounds from Mandevilla velutina on bradykinin-mediated contractile and relaxant responses of the isolated guinea pig trachea.
Topics: Animals; Bradykinin; Carbachol; Dinoprost; Epithelial Cells; Epithelium; Female; Guinea Pigs; Histam | 1992 |
Tracheal relaxation induced by potassium channel opening drugs: its antagonism by adrenergic neurone blocking agents.
Topics: Adrenergic Antagonists; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; | 1992 |
Inhibition by adrenergic neurone blocking agents of the relaxation induced by BRL 38227 in vascular, intestinal and uterine smooth muscle.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Bretylium Compounds; Cromakalim; Female; Guanethidine; Guinea | 1992 |
The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle.
Topics: Acetylcholine; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Drug Interactions; Histamine | 1992 |
Pharmacological characterization of a new purinergic receptor site in rabbit aorta.
Topics: Adenosine; Adenosine Triphosphate; Animals; Aorta, Thoracic; In Vitro Techniques; Male; Muscle Relax | 1992 |
Age-related changes in P2-purinergic receptors on vascular smooth muscle and endothelium.
Topics: Adenosine Triphosphate; Aging; Animals; Aorta; Dose-Response Relationship, Drug; Endothelium, Vascul | 1992 |
Influence of osmolarity of solutions used for K+ contraction on relaxant responses to pinacidil, verapamil, theophylline and terbutaline in isolated airway smooth muscle.
Topics: Animals; Guanidines; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle | 1992 |
On the purinergic system in rat duodenum: existence of P1 and P2 receptors on the smooth muscle.
Topics: Adenosine Triphosphate; Animals; Duodenum; Electric Stimulation; In Vitro Techniques; Muscle Relaxat | 1990 |
Leukotriene receptor antagonism and augmentation of beta-receptor-mediated events by LY171883.
Topics: 1-Methyl-3-isobutylxanthine; Acetophenones; Adrenergic beta-Agonists; Animals; Bronchodilator Agents | 1990 |
Evidence that adenosine is not involved in the non-adrenergic non-cholinergic relaxation in the rat duodenum.
Topics: Adenosine; Animals; Atropine; Duodenum; Electric Stimulation; Guanethidine; In Vitro Techniques; Iso | 1990 |
Guinea-pig isolated trachealis: the effects of charybdotoxin on mechanical activity, membrane potential changes and the activity of plasmalemmal K(+)-channels.
Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Calcium; Cell Membrane; Charybdotoxin; Cromakalim; G | 1991 |
Relaxant effects of theophylline and clenbuterol on tracheal smooth muscle from horse and rat in vitro.
Topics: Animals; Carbachol; Clenbuterol; Horses; Male; Muscle Relaxation; Muscle, Smooth; Rats; Rats, Inbred | 1991 |
Role of the epithelium in airway smooth muscle responses to relaxant agonists.
Topics: Albuterol; Animals; Arachidonic Acid; Bronchodilator Agents; Diffusion; Epithelium; Guinea Pigs; In | 1991 |
Direct effects of adenylyl 5'-(beta,gamma-methylene)diphosphonate, a stable ATP analogue, on relaxant P1-purinoceptors in smooth muscle.
Topics: Adenosine; Adenosine Triphosphate; Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxatio | 1991 |
Pharmacological effects of adenosine on canine penile erection.
Topics: Acetylcholine; Adenosine; Animals; Blood Flow Velocity; Blood Pressure; Cavernous Sinus; Dipyridamol | 1991 |
Dissociation between the effects of theophylline and caffeine on premature airway smooth muscles.
Topics: Acetylcholine; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Female; Humans; Infant, | 1991 |
Isoproterenol activation of prostaglandin production in guinea-pig airway muscle preparations from immature and mature animals.
Topics: Aging; Animals; Bronchi; Dinoprost; Dinoprostone; Enzyme Activation; Guinea Pigs; Histamine; Isoprot | 1991 |
Peripheral type benzodiazepine receptors and response to adenosine on the guinea-pig isolated trachea.
Topics: Adenosine; Animals; Benzodiazepines; Clonazepam; Diazepam; Dipyridamole; Drug Synergism; GABA-A Rece | 1990 |
Effects of cularine and other isoquinoline alkaloids on guinea-pig trachea and human bronchus.
Topics: Adenosine; Alkaloids; Animals; Bronchi; Calcium; Guinea Pigs; Histamine; Humans; In Vitro Techniques | 1990 |
Relaxant effects of adenosine analogs on guinea pig trachea in vitro: xanthine-sensitive and xanthine-insensitive mechanisms.
Topics: Adenosine; Animals; Carbachol; Deoxyadenosines; Guinea Pigs; In Vitro Techniques; Male; Muscle Relax | 1991 |
Effects of CGS-15943A on the relaxations produced by adenosine analogs in human blood vessels.
Topics: Adenosine; Adult; Coronary Vessels; Humans; In Vitro Techniques; Mammary Arteries; Middle Aged; Musc | 1990 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Te | 1990 |
[The relaxation of the coronary artery smooth muscles under the action of a high-potassium solution].
Topics: Animals; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Isotonic S | 1990 |
Theophylline minimally alters contractile properties of canine diaphragm in vitro.
Topics: Animals; Diaphragm; Diffusion; Dogs; Fatigue; In Vitro Techniques; Models, Biological; Muscle Contra | 1990 |
Abnormalities in airway smooth muscle in fatal asthma.
Topics: Acetylcholine; Adult; Asthma; Cholinergic Fibers; Electric Stimulation; Female; Histamine; Humans; I | 1990 |
Activities of caffeine, theophylline, and enprofylline analogs as tracheal relaxants.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Guinea Pigs; In Vitro Techniques; Male; | 1990 |
Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig.
Topics: Albuterol; Anesthesia; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Decerebrate State; D | 1990 |
Evidence that A2 purinoceptors are involved in endothelium-dependent relaxation of the rat thoracic aorta.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals | 1990 |
Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation.
Topics: Adenosine; Adenosine Triphosphate; Bronchi; Bronchodilator Agents; Carbachol; Histamine; Humans; In | 1985 |
Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung.
Topics: Adult; Asthma; Autoradiography; Bronchi; Carbachol; Humans; In Vitro Techniques; Iodine Radioisotope | 1989 |
Analysis of the relaxant effects of AH 21-132 in guinea-pig isolated trachealis.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholine; Animals; Female; Guinea Pigs; Histamine; | 1989 |
Inhibitory effects of AH 21-132 in guinea-pig isolated ileum and taenia caeci.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cecum; Electric S | 1989 |
A possible mechanism of action of tetramethylpyrazine on vascular smooth muscle in rat aorta.
Topics: Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Female; In Vitro Techniques | 1989 |
Postnatal changes in response to adenosine and adenine nucleotides in rat duodenum.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn; Duodenum; Female; | 1989 |
Apparent affinity of 1,3-dipropyl-8-cyclopentylxanthine for adenosine A1 and A2 receptors in isolated tissues from guinea-pigs.
Topics: Adenosine; Animals; Aorta, Thoracic; Binding, Competitive; Guinea Pigs; Heart Rate; In Vitro Techniq | 1989 |
Beta-adrenoceptor desensitization in guinea-pig isolated trachea.
Topics: Animals; Autoradiography; Carbachol; Female; Fenoterol; Guinea Pigs; Hydrocortisone; In Vitro Techni | 1988 |
Beta agonist-induced desensitization in pig bronchus.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Airway Resistance; Animals; Bronchi; Colforsi | 1986 |
Fenspiride and relaxation of tracheobronchial musculature. Mechanism of action.
Topics: Animals; Bronchi; Guinea Pigs; Humans; Muscle Contraction; Muscle Relaxation; Spiro Compounds; Theop | 1988 |
Different innervation mechanisms between the lesser and greater curvature of guinea pig antrum.
Topics: Animals; Apamin; Atropine; Chymotrypsin; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Cont | 1989 |
Further evidence for involvement of adenosine-5'-triphosphate in non-adrenergic non-cholinergic relaxation of the isolated rat duodenum.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Autonomi | 1985 |
[cAMP-dependent mechanism of relaxation of vascular smooth muscle cells in hypoxia not associated with decrease in the Ca2+ level in myoplasma].
Topics: Calcium; Cyclic AMP; Humans; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Oxyge | 1985 |
Calcium entry blocking activity of dilazep in dog coronary artery.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Arteries; Azepines; Calcium; Calcium Channel Block | 1986 |
Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study.
Topics: Adult; Aged; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; | 1988 |
Involvement of P1-purinoreceptors in the relaxing effect of adenosine in rat duodenum.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Duodenum; In Vitro Techniques; Male; Muscle Co | 1988 |
New methylxanthine thio-derivatives inducing marked tracheal relaxation without increasing cardiac inotropism or motor activity.
Topics: Animals; Caffeine; Guinea Pigs; In Vitro Techniques; Mice; Motor Activity; Muscle Relaxation; Muscle | 1988 |
Slowing of relaxation in the fatiguing hamster diaphragm is enhanced by theophylline.
Topics: Animals; Caffeine; Calcium; Cricetinae; Diaphragm; In Vitro Techniques; Mesocricetus; Muscle Contrac | 1988 |
Studies on alkyl-xanthine derivatives. II. Pharmacokinetic and pharmacodynamic studies of a new bronchodilator, 1-methyl-3-propylxanthine (MPX).
Topics: Animals; Bronchodilator Agents; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Rats; Rat | 1988 |
Adenosine 5'-(2-fluorodiphosphate) is a selective agonist at P2-purinoceptors mediating relaxation of smooth muscle.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aorta, Thoracic; Colon; Guinea Pigs; In Vitr | 1988 |
The response of isolated guinea-pig aorta to amrinone.
Topics: Adenosine; Adenosine Deaminase; Amrinone; Animals; Aorta, Thoracic; Female; Guinea Pigs; In Vitro Te | 1988 |
Interaction of azelastine with adenosine receptors in guinea pig trachea.
Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Phenylisopropyladenosine; Phthal | 1988 |
Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study.
Topics: Female; Humans; In Vitro Techniques; Muscle Relaxation; Myometrium; Papaverine; Phosphodiesterase In | 1987 |
Effects of adenosine and theophylline on canine tracheal smooth muscle tone.
Topics: Adenine; Adenosine; Animals; Dipyridamole; Dogs; Drug Interactions; In Vitro Techniques; Inosine; Ma | 1987 |
The role of myogenic relaxation, adenosine and prostaglandins in human forearm reactive hyperaemia.
Topics: Adenosine; Adult; Arteries; Constriction; Female; Forearm; Humans; Ibuprofen; Male; Muscle Contracti | 1987 |
Suppression by 5'-methylthioadenosine of histamine or leukotriene-induced contraction in isolated guinea pig tracheal rings.
Topics: Adenosine; Animals; Deoxyadenosines; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Hi | 1986 |
Effects of theophylline on small human placental arteries in vitro.
Topics: Dinoprost; Dinoprostone; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; | 1985 |
Effect of calcium entry blockers and adenosine on the relaxation of large and small coronary arteries.
Topics: Adenosine; Animals; Arteries; Calcium Channel Blockers; Cattle; Coronary Vessels; Dose-Response Rela | 1986 |
Evidence that the intracellular effects of adenosine in the guinea-pig aorta are mediated by inosine.
Topics: Adenosine; Animals; Aorta, Thoracic; Female; Guinea Pigs; In Vitro Techniques; Inosine; Male; Muscle | 1986 |
Cellular Ca2+ monitored by aequorin in adenosine-mediated smooth muscle relaxation.
Topics: Adenosine; Aequorin; Animals; Body Fluids; Calcium; Dose-Response Relationship, Drug; Electric Stimu | 1985 |
Effect of adenosine 5'triphosphate (ATP) on the isolated rectum of the rainbow lizard Agama agama.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Chloride; Carbachol; Dipyridamole; In Vitro Techni | 1985 |