Page last updated: 2024-10-22

theophylline and Muscle Relaxation

theophylline has been researched along with Muscle Relaxation in 174 studies

Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.

Research Excerpts

ExcerptRelevanceReference
" The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit."7.69Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994)
"Melatonin treatment strengthened contraction responses, but did not affect relaxation responses in rat tracheal preparations."5.38The achilles heel in melatonin: asthma. ( Belgin Yildirim, F; Karasu-Minareci, E; Kaya, Y, 2012)
"Adenosine pretreatment (3."5.27Cellular Ca2+ monitored by aequorin in adenosine-mediated smooth muscle relaxation. ( Bradley, AB; Morgan, KG, 1985)
"inhaled magnesium sulphate in acute asthma was shown to improve lung function measures (one trial, 60 women); intravenous theophylline in acute asthma was not associated with benefits (one trial, 65 women)."4.90Interventions for managing asthma in pregnancy. ( Bain, E; Clifton, VL; Crowther, CA; Hodyl, NA; Middleton, P; Pierides, KL; Stark, MJ, 2014)
"Theophylline is a drug commonly used to treat asthma due to its anti-inflammatory and bronchodilatory properties."4.31Theophylline-Induced Relaxation Is Enhanced after Testosterone Treatment via Increased K ( Carbajal-García, A; Casas-Hernández, MF; Díaz-Hernández, V; Montaño, LM; Reyes-García, J; Sommer, B, 2023)
" The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit."3.69Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994)
" When compounds were intraduodenally administered to the guinea pig, 1-(2'-ethoxyethyl)-, 1-(3'-methoxypropyl)-, 1-(3'-butenyl)-, and 1-[(dimethylamino)-ethyl]-3-propylxanthines, 1-methyl-7-(2'-oxopropyl)-3-propylxanthine, and denbufylline (1,3-di-n-butyl-7-(2'-oxopropyl)xanthine) effectively inhibited the acetylcholine-induced bronchospasm without heart stimulation or central nervous system-stimulation at the effective dosage range."3.68Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. ( Hasegawa, T; Iwasaki, N; Konno, K; Kurita, M; Miyamoto, K; Ohshima, T; Sakai, R; Sanae, F; Takagi, K; Yamamoto, Y, 1993)
" The rate and amplitude of smooth muscle relaxation at low PO2 were significantly decreased by tolbutamide (5 mmol l-1), which is known to inhibit cyclic AMP-dependent protein kinases."3.68Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats. ( Basilyuk, OV; Soloviev, AI, 1993)
"We examined the effects of theophylline on contractile properties and high-frequency fatigue of canine diaphragm in vitro."3.68Theophylline minimally alters contractile properties of canine diaphragm in vitro. ( De Bock, V; Decramer, M; Derom, E; Janssens, S, 1990)
" The autoradiographic distribution of alpha 1-adrenoceptors was investigated in non-diseased and asthmatic human lung by use of [3H]-prazosin (H-PZ)."3.67Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung. ( Goldie, RG; Paterson, JW; Rigby, PJ; Spina, D, 1989)
"Melatonin treatment strengthened contraction responses, but did not affect relaxation responses in rat tracheal preparations."1.38The achilles heel in melatonin: asthma. ( Belgin Yildirim, F; Karasu-Minareci, E; Kaya, Y, 2012)
"This study investigates the effect of theophylline along the rabbit gastrointestinal tract in comparison with the pharmacodynamic effect produced by the combined application of its three major metabolites."1.36The gastrointestinal effects that may follow the administration of theophylline reflect the pharmacodynamic profiles of both the parent drug and its metabolites. ( Batzias, GC; Koutsoviti-Papadopoulou, M; Peeters, TL; Psarra, TA, 2010)
" The here obtained pharmacodynamic profiles of the drugs suggest that both milrinone and theophylline may be considered as potent relaxing agents of the lower oesophageal sphincter."1.35Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit. ( Batzias, GC; Koutsoviti-Papadopoulou, M; Psarra, TA, 2009)
" Among them, 3,4-dipropyl-4,5,7,8-tetrahydro-3H-imidazo[1,2-i]-purin-5-one (1c), which was the most selective and potent PDE IV inhibitor, did not cause emesis in Suncus murinus at a dosage range of 10-100 mg/kg (po), while an imidazole analogue of 1c (4c) and known PDE IV inhibitors such as rolipram and denbufylline caused emesis even at 10 or 30 mg/kg."1.30Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines. ( Kasugai, S; Miyamoto, K; Ohya, K; Sawanishi, H; Suzuki, H; Suzuki, N; Takagi, K; Waki, Y; Yamamoto, S, 1997)
"Pretreatment with verapamil (1 or 10 microM), nifedipine (0."1.29The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine. ( Cortijo, J; Morcillo, EJ; Sanz, CM; Small, RC; Villagrasa, V, 1994)
" The nitric oxide (NO) synthase inhibitor, L-monomethyl-L-arginine (30 microM) shifted the dose-response curve for NECA to the right in all groups suggesting that the vascular response to NECA is partially mediated through the release of NO."1.29Influence of aortic baroreceptor denervation on adenosine receptor-mediated relaxation of isolated rat aorta. ( Abdel-Rahman, AA; el-Mas, MM; Fahim, M; Mustafa, SJ, 1994)
" Dose-response data for both agonists were best represented by two-site models."1.29A biphasic response to adenosine in the coronary vasculature of the K(+)-arrested perfused rat heart. ( Harden, FA; Harrison, GJ; Headrick, J; Jordan, LR; Willis, RJ, 1996)
" Compound MV 8612 (8 and 16 microM) and MV 8610 (12 and 24 microM) caused a graded rightward displacement of BK dose-response curves in the isolated guinea pig trachea (dose ratio 2- to 4-fold)."1.28Effect of compounds from Mandevilla velutina on bradykinin-mediated contractile and relaxant responses of the isolated guinea pig trachea. ( Calixto, JB; Cruz, AB; Medeiros, YS; Yunes, RA, 1992)
"Cromakalim (BRL 34915) is a potassium channel opener with therapeutic potential as a bronchodilator in asthma."1.28The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle. ( Cortijo, J; Morcillo, E; Paris, F; Pedrós, C; Perpiñá, M; Sarriá, B, 1992)
"Adenosine analogs were tested for their ability to relax carbachol-contracted trachea in vitro."1.28Relaxant effects of adenosine analogs on guinea pig trachea in vitro: xanthine-sensitive and xanthine-insensitive mechanisms. ( Brackett, LE; Daly, JW, 1991)
"Theophylline was markedly less potent than any of the other agents."1.28Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig. ( Cowlrick, IS; Paciorek, PM; Perkins, RS; Taylor, JC; Waterfall, JF; Wilkinson, GF, 1990)
"Since terbutaline treatment in premature labor has been shown to increase phosphodiesterase activity in the myometrium, the phosphodiesterase-inhibiting effect of theophylline and papaverine on myometrial preparations from pregnant women has been studied."1.27In vitro study of phosphodiesterase-inhibiting drugs: a complement to beta-sympathomimetic drug therapy in premature labor? ( Andersson, RG; Berg, G; Rydén, G, 1983)
"2 Pretreatment with theophylline (25-50 microM) had no significant effect on the concentration-response curves obtained with either purine compound."1.27Purine receptors in the guinea-pig internal anal sphincter. ( Crema, A; Frigo, GM; Lecchini, S; Manzo, L; Onori, L; Tonini, M, 1983)
"Enprofylline was more potent than theophylline in relaxing the egg albumin- or SRS-A-induced tracheal muscle tone."1.27Potent bronchodilating effects of enprofylline and theophylline on contractions induced by egg albumin or by slow reacting substance (SRS). ( Andersson, RG; Hedman, SE, 1984)
"Papaverine was shown to be the substance able to cause the biggest relaxation effect."1.27Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study. ( Barbanti, G; Beneforti, P; Lapini, A; Turini, D, 1988)
" We evaluated their relaxant effects on tracheal smooth muscle isolated from guinea pigs and pharmacokinetic characteristics in rats using 1,3-dimethylxanthine (theophylline, TPH) as the reference drug."1.27Studies on alkyl-xanthine derivatives. II. Pharmacokinetic and pharmacodynamic studies of a new bronchodilator, 1-methyl-3-propylxanthine (MPX). ( Hasegawa, T; Kuzuya, T; Miyamoto, K; Nadai, M; Ogawa, K; Ruttikorn, A; Takagi, K, 1988)
"Theophylline was less potent in relaxing the potassium induced contraction."1.27Effects of theophylline on small human placental arteries in vitro. ( Nielsen-Kudsk, JE, 1985)
"Adenosine pretreatment (3."1.27Cellular Ca2+ monitored by aequorin in adenosine-mediated smooth muscle relaxation. ( Bradley, AB; Morgan, KG, 1985)
"5 Indomethacin treatment reversed the isoprenaline desensitization induced by chronic treatment (0."1.26Tolerance of guinea-pig airway muscle preparations to relaxant agonists induced by chronic exposure to isoprenaline in vivo. ( Brink, C, 1981)
"Proxyphylline was excreted in urine both an unchanged compound (12."1.26Human metabolism of 7-substituted theophyllines: N3-demethylation and lack of oxidation of proxyphylline. ( Garcia, I; Segura, J; Tarrus, E, 1981)

Research

Studies (174)

TimeframeStudies, this research(%)All Research%
pre-199070 (40.23)18.7374
1990's75 (43.10)18.2507
2000's16 (9.20)29.6817
2010's12 (6.90)24.3611
2020's1 (0.57)2.80

Authors

AuthorsStudies
Suzuki, F1
Kuroda, T1
Kawakita, T1
Manabe, H1
Kitamura, S1
Ohmori, K1
Ichimura, M1
Kase, H1
Ichikawa, S1
Millen, J1
Riley, TN1
Waters, IW1
Hamrick, ME1
Miyamoto, K4
Yamamoto, Y1
Kurita, M2
Sakai, R2
Konno, K1
Sanae, F2
Ohshima, T1
Takagi, K4
Hasegawa, T2
Iwasaki, N1
Sawanishi, H1
Suzuki, H2
Yamamoto, S1
Waki, Y1
Kasugai, S1
Ohya, K1
Suzuki, N1
Ríos-Santamarina, I1
García-Domenech, R1
Gálvez, J1
Cortijo, J4
Santamaria, P1
Morcillo, E2
Campillo, N1
García, C1
Goya, P1
Alkorta, I1
Páez, JA1
Reyes-García, J1
Díaz-Hernández, V1
Carbajal-García, A1
Casas-Hernández, MF1
Sommer, B1
Montaño, LM1
Emami, B1
Shakeri, F1
Ghorani, V1
Boskabady, MH8
Patai, Z1
Guttman, A1
Mikus, EG1
Keyhanmanesh, R2
Saadatloo, MA1
Boskabady, M1
Bain, E1
Pierides, KL1
Clifton, VL1
Hodyl, NA1
Stark, MJ1
Crowther, CA1
Middleton, P1
Yuzkat, N1
Kati, I1
Isik, Y1
Kavak, S1
Goktas, U1
Cengiz, N1
Psarra, TA3
Batzias, GC3
Peeters, TL2
Koutsoviti-Papadopoulou, M3
Bozarov, A1
Wang, YZ1
Yu, JG1
Wunderlich, J1
Hassanain, HH1
Alhaj, M1
Cooke, HJ1
Grants, I1
Ren, T1
Christofi, FL1
Zhang, Y2
Miller, DV1
Paterson, WG1
Aronsson, P1
Andersson, M1
Ericsson, T1
Giglio, D2
Ozolua, RI1
Adejayan, A1
Aigbe, OP1
Uwaya, DO1
Argawal, A1
Tazzeo, T1
Bates, G1
Roman, HN1
Lauzon, AM1
Khasnis, MD1
Eto, M1
Janssen, LJ1
Karasu-Minareci, E1
Kaya, Y1
Belgin Yildirim, F1
Tasatargil, A1
Sadan, G4
Ozdem, SS1
Jandaghi, P1
Ramazani, M1
Tabei, T1
Usta, C2
Tuncel, B1
Delbro, DS1
Tobin, G1
Aslani, MR2
Kiani, S2
Rakhshandah, H1
Karlsson, JA3
Persson, CG3
Middleton, E1
Bergstrand, H1
Ishikawa, Y1
Takahashi, T2
Yamamura, T2
Rohner, TJ1
Hannigan, J1
Webb, RC1
Bohr, DF1
Brink, C2
Polson, JB3
Krzanowski, JJ3
Szentivanyi, A3
Berg, G2
Andersson, RG3
Rydén, G2
Crema, A1
Frigo, GM1
Lecchini, S1
Manzo, L1
Onori, L1
Tonini, M1
Mehta, AK1
Kulkarni, SK1
Kukovetz, WR1
Pöch, G1
Holzmann, S1
Collis, MG4
Brown, CM1
Darius, H1
Weiss, P1
Schrör, K1
Satchell, D1
Smith, R1
Hedman, SE1
Zuskin, E2
Duncan, PG2
Douglas, JS2
Barron, JT1
Bárány, M1
Bárány, K1
Storti, RV1
Tarrus, E1
Garcia, I1
Segura, J1
Norris, AA1
Eyre, P1
Gordon, VP1
Kimura, I1
Kimura, M1
Yoshimura, Y1
Muramatsu, I1
Fujiwara, M1
Miura, A1
Shibata, S3
Chevillard, C1
Saiag, B1
Worcel, M1
Vials, AJ2
Burnstock, G3
Hussain, T1
Leigh, JH1
Mustafa, SJ5
Prentice, DJ3
Shankley, NP1
Black, JW1
Mellemkjaer, S2
Nielsen-Kudsk, JE4
Tsunoda, R1
Okumura, K1
Ishizaka, H1
Matsunaga, T1
Tabuchi, T1
Yasue, H1
Akaike, T1
Sato, K1
Maeda, H1
Lewis, CD1
Hourani, SM6
Long, CJ1
Lin, CI1
Wu, SL1
Tao, PL1
Chen, HM1
Wei, J1
Martin, PL1
Potts, AA1
Wakusawa, S1
Jiang, C1
Collins, P1
Sanz, CM1
Villagrasa, V1
Morcillo, EJ1
Small, RC6
Kokubun, S1
Vuorinen, P1
Wu, X1
Arvola, P1
Vapaatalo, H1
Pörsti, I1
Boland, B1
Himpens, B1
Paques, C1
Casteels, R1
Gillis, JM1
Iwamoto, T1
Umemura, S1
Toya, Y1
Uchibori, T1
Kogi, K1
Takagi, N1
Ishii, M1
Najbar, A1
Li, CG1
Rand, MJ1
Sarriá, B2
Naline, E2
Brisac, AM1
Laurent, S1
Advenier, C4
Fahim, M1
el-Mas, MM1
Abdel-Rahman, AA1
Vials, A1
Fedan, JS1
Belt, JJ1
Yuan, LX1
Frazer, DG1
Soloviev, AI1
Basilyuk, OV1
Lin, CH1
Ko, FN1
Wu, YC1
Lu, ST1
Teng, CM1
Michel, A1
Laurent, F1
Chapat, JP1
Boucard, M1
Bonnet, PA1
Souccar, C1
Gonçalo, Mdo C1
Lapa, AJ1
Troncone, LR1
Lebrun, I1
Magnoli, F1
Nicholls, J2
Brownhill, VR1
Harden, FA1
Harrison, GJ1
Headrick, J1
Jordan, LR1
Willis, RJ1
Piper, AS1
Hollingsworth, M2
Planquois, JM1
Ruffin-Morin, Y1
Lagente, V1
Payne, AN1
Dahl, SG1
Kaputlu, I1
Yoshihara, S1
Lindén, A1
Kashimoto, K1
Nagano, Y1
Ichimura, T1
Nadel, JA1
Broadley, KJ1
Maddock, HL1
Thirstrup, S1
Nielsen-Kudsk, F1
Dahl, R1
Rubinstein, R1
Shalev, M1
Nissenkorn, I1
Cohen, S1
Hernández, M1
Barahona, MV1
Bustamante, S1
García-Sacristán, A1
Orensanz, LM1
Satake, N2
Imanishi, M1
Bültmann, R2
Starke, K2
Fayon, MJ1
Denis, D1
Molimard, M1
Berger, P1
Choukroun, ML1
Demarquez, JL1
Marthan, R1
Clevel, H1
Lachaud, JL1
Martinez, B1
Téchoueyres, P1
Klebroff, W1
Lefebvre, RA1
Willems, JL1
Anderson, WH1
Fitzpatrick, DF1
Hwang, DP1
Gerritsen, ME1
Mathison, R1
Lederis, K1
Lohmann, SM1
Miech, RP1
Butcher, FR1
Johansson, SR1
Anderson, RG1
Kolbeck, RC1
Speir, WA1
Carrier, GO1
Bransome, ED1
Fredholm, BB1
Brodin, K1
Strandberg, K1
Baer, HP1
Frew, R1
Ueda, S1
Ikegami, K1
Sakanashi, M1
Yonemura, KI1
Okwuasaba, FK1
Hamilton, JT1
Cook, MA1
Cambar, J1
Saurel, J1
Canellas, J1
Pfaffman, MA1
McFarland, SA1
Filbert, MG1
Moore, DH1
Adler, M1
Jenne, JW1
Yeoh, HC1
Shaughnessy, TK1
Hur, K1
Miura, M1
Belvisi, MG1
Stretton, CD1
Yacoub, MH1
Barnes, PJ1
Calixto, JB1
Yunes, RA1
Cruz, AB1
Medeiros, YS1
Berry, JL3
Foster, RW4
Hughes, SJ1
Smith, RD1
Miller, AJ1
Edwards, G1
Weston, AH1
Pedrós, C1
Perpiñá, M1
Paris, F1
Chinellato, A1
Ragazzi, E2
Pandolfo, L1
Froldi, G2
Caparrotta, L1
Fassina, G2
Koga, T1
Takata, Y1
Kobayashi, K1
Fujii, K1
Nagao, T1
Fujishima, M1
Nielsen, CB1
Postorino, A2
Serio, R2
Mulè, F2
Rinkema, LE1
Roman, CR1
Russell, WL1
Spaethe, SM1
Bemis, KG1
Henry, DP1
Marshall, WS1
Fleisch, JH1
Murray, MA1
Cook, SJ1
Green, KA1
Ingvast-Larsson, C1
Yang, JN1
Mitzner, W1
Hirshman, C1
Bailey, SJ1
Kitchen, I1
Takahashi, Y1
Ishii, N1
Lue, TF1
Tanagho, EA1
Mehta, PN1
Panitch, HB1
Wolfson, MR1
Shaffer, TH1
Labat, C1
Braunstein, G1
Devillier, P1
Blanc, M1
Gnassounou, JP1
Candenas, ML1
D'Ocón, MP1
Cortes, D1
Brackett, LE2
Daly, JW2
Sabouni, MH1
Brown, GL1
Kotake, AN1
Douglas, FL1
Bang, L1
Brønsgaard, AM1
Nikitina, EI1
Landsberg, KF1
Vaughan, LM1
Heffner, JE1
Derom, E1
Janssens, S1
De Bock, V1
Decramer, M1
Bai, TR1
Shamim, MT1
Paciorek, PM1
Cowlrick, IS1
Perkins, RS1
Taylor, JC1
Wilkinson, GF1
Waterfall, JF1
Rose'Meyer, RB1
Hope, W1
Finney, MJ1
Spina, D3
Rigby, PJ2
Paterson, JW3
Goldie, RG3
Boyle, JP2
Duty, S1
Elliott, KR2
Watt, AJ2
Wu, CC1
Chiou, WF1
Yen, MH1
Furukawa, K1
Nomoto, T1
Stoggall, SM1
Martin, FM1
Fernandes, LB1
Knight, DA1
Kantoh, M1
Kusunoki, M1
Utsunomiya, J1
Manzini, S1
Maggi, CA1
Meli, A1
Solov'ev, AI1
Nakagawa, Y1
Gudenzi, M1
Barbanti, G1
Beneforti, P1
Lapini, A1
Turini, D1
Gaion, RM2
Dorigo, P2
Trolese, B1
Borin, E1
Adami, R1
Gambarotto, L1
Santi Soncin, E1
Esau, SA1
Ruttikorn, A1
Nadai, M1
Kuzuya, T1
Ogawa, K1
Svedmyr, N1
Welford, LA1
Loizou, GD1
Cusak, NJ1
Ceroni, G1
Giacometti, A1
Valentini, E1
Maragno, I1
Achterrath-Tuckermann, U1
Szelenyi, I1
Urdaneta-Bohorquez, A1
Sakamoto, Y1
Carlsson, I1
Sollevi, A1
Wennmalm, A1
Nishida, Y1
Suzuki, S1
Miyamoto, T1
Askar, AO1
Palmer, DB1
Baxter, GS1
Bradley, AB1
Morgan, KG1
Savage, AO1
Atanga, GK1

Reviews

4 reviews available for theophylline and Muscle Relaxation

ArticleYear
Interventions for managing asthma in pregnancy.
    The Cochrane database of systematic reviews, 2014, Oct-21, Issue:10

    Topics: Adrenal Cortex Hormones; Algorithms; Anti-Asthmatic Agents; Asthma; Beclomethasone; Female; Humans;

2014
Airway smooth muscle, asthma, and calcium ions.
    The Journal of allergy and clinical immunology, 1984, Volume: 73, Issue:5 Pt 2

    Topics: Asthma; Asthma, Exercise-Induced; Autacoids; Binding Sites; Calcium; Calcium Channel Blockers; Calmo

1984
Phosphodiesterase inhibition and theophylline.
    European journal of respiratory diseases. Supplement, 1980, Volume: 109

    Topics: 1-Methyl-3-isobutylxanthine; Cromolyn Sodium; Histamine Release; Humans; Kinetics; Lung; Muscle Rela

1980
Airway smooth muscle and disease workshop: theophylline.
    The American review of respiratory disease, 1987, Volume: 136, Issue:4 Pt 2

    Topics: Animals; Asthma; Bronchi; Bronchodilator Agents; Guinea Pigs; Humans; In Vitro Techniques; Muscle Re

1987

Trials

1 trial available for theophylline and Muscle Relaxation

ArticleYear
The effect of theophylline on respiratory muscle contractility and fatigue.
    Pharmacotherapy, 1990, Volume: 10, Issue:4

    Topics: Animals; Diaphragm; Dogs; Double-Blind Method; Fatigue; Guinea Pigs; Humans; Lung Diseases, Obstruct

1990

Other Studies

169 other studies available for theophylline and Muscle Relaxation

ArticleYear
New bronchodilators. 3. Imidazo[4,5-c][1,8]naphthyridin-4(5H)-ones.
    Journal of medicinal chemistry, 1992, Dec-25, Volume: 35, Issue:26

    Topics: Animals; Bronchodilator Agents; Drug Interactions; Guinea Pigs; Imidazoles; Male; Mice; Muscle Relax

1992
2-(beta-Arylethylamino)- and 4-(beta-arylethylamino)quinazolines as phosphodiesterase inhibitors.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:1

    Topics: Animals; Cattle; Ethylamines; Female; Guinea Pigs; Muscle Relaxation; Muscle, Smooth; Myocardium; Ph

1985
Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.
    Journal of medicinal chemistry, 1993, May-14, Volume: 36, Issue:10

    Topics: Administration, Oral; Animals; Bronchial Spasm; Bronchodilator Agents; Guinea Pigs; Heart Rate; Male

1993
Selective inhibitors of cyclic AMP-specific phosphodiesterase: heterocycle-condensed purines.
    Journal of medicinal chemistry, 1997, Sep-26, Volume: 40, Issue:20

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiester

1997
New bronchodilators selected by molecular topology.
    Bioorganic & medicinal chemistry letters, 1998, Mar-03, Volume: 8, Issue:5

    Topics: Animals; Bronchodilator Agents; Discriminant Analysis; Female; Guinea Pigs; In Vitro Techniques; Mal

1998
Novel bronchodilators: synthesis, transamination reactions, and pharmacology of a series of pyrazino[2,3-c][1,2,6]thiadiazine 2, 2-dioxides.
    Journal of medicinal chemistry, 2000, Nov-02, Volume: 43, Issue:22

    Topics: Animals; Bronchoconstriction; Bronchodilator Agents; Guinea Pigs; Lethal Dose 50; Magnetic Resonance

2000
Theophylline-Induced Relaxation Is Enhanced after Testosterone Treatment via Increased K
    International journal of molecular sciences, 2023, Mar-20, Volume: 24, Issue:6

    Topics: Animals; Asthma; Female; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Sexual Maturation; Te

2023
Relaxant effect of Curcuma longa on rat tracheal smooth muscle and its possible mechanisms.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Animals; Bronchodilator Agents; Curcuma; Dose-Response Relationship, Drug; Ethanol; Male; Methacholi

2017
Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine.
    Pharmacology, 2018, Volume: 101, Issue:3-4

    Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smoo

2018
Contribution of water and lipid soluble substances in the relaxant effects of Tymus vulgaris extract on guinea pig tracheal smooth muscle in vitro.
    Chinese journal of integrative medicine, 2016, Volume: 22, Issue:5

    Topics: Animals; Bronchodilator Agents; Guinea Pigs; In Vitro Techniques; Lamiaceae; Lipids; Muscle Relaxati

2016
Effects of Theophylline with Methylprednisolone Combination Therapy on Biomechanics and Histopathology in Diaphragm Muscles of Rats.
    Inflammation, 2016, Volume: 39, Issue:5

    Topics: Animals; Biomechanical Phenomena; Diaphragm; Drug Synergism; Drug Therapy, Combination; Methylpredni

2016
Relaxing and contracting effects of theophylline's metabolites on the rabbit upper gastrointestinal tract.
    Fundamental & clinical pharmacology, 2008, Volume: 22, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Muscle Contraction; Mu

2008
Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit.
    Journal of veterinary pharmacology and therapeutics, 2009, Volume: 32, Issue:2

    Topics: Animals; Bronchodilator Agents; Esophageal Sphincter, Lower; Female; Male; Milrinone; Muscle Relaxat

2009
The gastrointestinal effects that may follow the administration of theophylline reflect the pharmacodynamic profiles of both the parent drug and its metabolites.
    Fundamental & clinical pharmacology, 2010, Volume: 24, Issue:2

    Topics: Acetylcholine; Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Gastrointes

2010
Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:6

    Topics: Adenosine; Animals; Chlorides; Cimetidine; Colon; Dihydropyridines; Dimaprit; Dose-Response Relation

2009
TREK-1 channels do not mediate nitrergic neurotransmission in circular smooth muscle from the lower oesophageal sphincter.
    British journal of pharmacology, 2010, Jan-01, Volume: 159, Issue:2

    Topics: Animals; Calcium; Colon; Esophageal Sphincter, Lower; Female; In Vitro Techniques; Male; Membrane Po

2010
Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder.
    Basic & clinical pharmacology & toxicology, 2010, Volume: 107, Issue:1

    Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Drug Antagonism; Electr

2010
Some characteristic relaxant effects of aqueous leaf extract of Andrographis paniculata and andrographolide on guinea pig tracheal rings.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2011, Dec-20, Volume: 26, Issue:2

    Topics: Andrographis; Animals; Calcium; Carbachol; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hi

2011
Caffeine relaxes smooth muscle through actin depolymerization.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Aug-15, Volume: 303, Issue:4

    Topics: Actins; Animals; Biopolymers; Caffeine; Cattle; Enzyme Assays; Humans; In Vitro Techniques; Indoles;

2012
Relaxant effects of different fractions from Tymus vulgaris on guinea-pig tracheal chains.
    Biological research, 2012, Volume: 45, Issue:1

    Topics: Animals; Bronchodilator Agents; Female; Guinea Pigs; Hexanes; Male; Methanol; Methylene Chloride; Mu

2012
The achilles heel in melatonin: asthma.
    Iranian journal of allergy, asthma, and immunology, 2012, Volume: 11, Issue:3

    Topics: Acetylcholine; Animals; Asthma; Circadian Rhythm; Dose-Response Relationship, Drug; Injections, Intr

2012
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries.
    Autonomic & autacoid pharmacology, 2003, Volume: 23, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Argini

2003
Relaxant effects of carvacrol on guinea pig tracheal chains and its possible mechanisms.
    Die Pharmazie, 2003, Volume: 58, Issue:9

    Topics: Animals; Bronchoconstrictor Agents; Bronchodilator Agents; Central Nervous System Depressants; Cymen

2003
Relaxant effects of different fractions of essential oil from Carum copticum on guinea pig tracheal chains.
    Phytotherapy research : PTR, 2003, Volume: 17, Issue:10

    Topics: Animals; Bronchodilator Agents; Carum; Chlorpheniramine; Dose-Response Relationship, Drug; Ethanol;

2003
The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations.
    Prostaglandins, leukotrienes, and essential fatty acids, 2004, Volume: 71, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Guinea Pigs; Histamine; In Vitro Techniques; Indom

2004
Postjunctional modulation by muscarinic M2 receptors of responses to electrical field stimulation of rat detrusor muscle preparations.
    Autonomic & autacoid pharmacology, 2005, Volume: 25, Issue:3

    Topics: Animals; Diamines; Electric Stimulation; In Vitro Techniques; Muscarinic Antagonists; Muscle Contrac

2005
Relaxant effect of Thymus vulgaris on guinea-pig tracheal chains and its possible mechanism(s).
    Phytotherapy research : PTR, 2006, Volume: 20, Issue:1

    Topics: Animals; Bronchodilator Agents; Dose-Response Relationship, Drug; Guinea Pigs; Male; Methacholine Ch

2006
Relaxant effects of Rosa damascena on guinea pig tracheal chains and its possible mechanism(s).
    Journal of ethnopharmacology, 2006, Jul-19, Volume: 106, Issue:3

    Topics: Animals; Bronchi; Bronchodilator Agents; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle

2006
Relaxant effect of Crocus sativus (saffron) on guinea-pig tracheal chains and its possible mechanisms.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:10

    Topics: Animals; Bronchi; Bronchodilator Agents; Carotenoids; Crocus; Cyclohexenes; Dose-Response Relationsh

2006
Neither vasoactive intestinal peptide (VIP) nor purine derivatives may mediate non-adrenergic tracheal inhibition.
    Acta physiologica Scandinavica, 1984, Volume: 122, Issue:4

    Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Atropine; Carbachol; Electric Stimulation; Fema

1984
[Action of adenosine 5'-triphosphate and effects of various purinergic receptor blocking agents on the movements of an isolated guinea pig gallbladder].
    Nihon Heikatsukin Gakkai zasshi, 1983, Volume: 19, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Apamin; Atropine; Female; Gallbladder;

1983
Effect of norepinephrine and isoproterenol on in vitro detrusor muscle contractility and cyclic AMP content.
    Investigative urology, 1980, Volume: 17, Issue:4

    Topics: Animals; Cyclic AMP; Dogs; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Mus

1980
Relaxation of vascular smooth muscle by isoproterenol, dibutyryl-cyclic AMP and theophylline.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 217, Issue:1

    Topics: Animals; Arteries; Bucladesine; Cats; Dogs; Female; In Vitro Techniques; Isoproterenol; Male; Muscle

1981
Tolerance of guinea-pig airway muscle preparations to relaxant agonists induced by chronic exposure to isoprenaline in vivo.
    British journal of pharmacology, 1981, Volume: 73, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Female; Guinea Pigs; Histamine; In Vitro

1981
Inhibition of a high affinity cyclic AMP phosphodiesterase and relaxation of canine tracheal smooth muscle.
    Biochemical pharmacology, 1982, Nov-01, Volume: 31, Issue:21

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Caffeine; Cyclic AMP; Dogs; Etazolate; Female; Male; M

1982
In vitro study of phosphodiesterase-inhibiting drugs: a complement to beta-sympathomimetic drug therapy in premature labor?
    American journal of obstetrics and gynecology, 1983, Apr-01, Volume: 145, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Drug Interactions; Female; Humans; Muscle Relaxation; My

1983
Purine receptors in the guinea-pig internal anal sphincter.
    British journal of pharmacology, 1983, Volume: 78, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Anal Canal; Animals; Dose-Response Relationship, Drug; Female; Gu

1983
Evidence for the presence of P1- and P2-purinoceptors in rat caecum.
    Archives internationales de pharmacodynamie et de therapie, 1983, Volume: 264, Issue:2

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Caffeine; Cecum; Cyclic AMP; Female;

1983
Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:10

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Aminophylline; Animals; Cattle; Drug Synergi

1983
Adenosine relaxes the aorta by interacting with an A2 receptor and an intracellular site.
    European journal of pharmacology, 1983, Dec-09, Volume: 96, Issue:1-2

    Topics: Adenosine; Animals; Aorta; Dipyridamole; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques

1983
Stereospecific stimulation of coronary vascular PGI2 by organic nitrates--studies with the new compound teopranitol (KC-046).
    Biomedica biochimica acta, 1984, Volume: 43, Issue:8-9

    Topics: Animals; Caffeine; Cattle; Coronary Vessels; Epoprostenol; In Vitro Techniques; Muscle Relaxation; N

1984
Adenosine causes contractions in spiral strips and relaxations in transverse strips of guinea-pig trachea: studies on mechanism of action.
    European journal of pharmacology, 1984, Jun-01, Volume: 101, Issue:3-4

    Topics: Adenosine; Adenosine Triphosphate; Animals; Dipyridamole; Female; Guinea Pigs; In Vitro Techniques;

1984
Potent bronchodilating effects of enprofylline and theophylline on contractions induced by egg albumin or by slow reacting substance (SRS).
    Acta pharmacologica et toxicologica, 1984, Volume: 55, Issue:2

    Topics: Adenosine Deaminase; Albumins; Animals; Bronchi; Female; Guinea Pigs; Male; Muscle Contraction; Musc

1984
The pharmacological characterization of aqueous extracts of vegetable dusts.
    Lung, 1983, Volume: 161, Issue:5

    Topics: Animals; Caffeine; Coffee; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Rela

1983
Reversible phosphorylation and dephosphorylation of the 20,000-dalton light chain of myosin during the contraction-relaxation-contraction cycle of arterial smooth muscle.
    The Journal of biological chemistry, 1980, Jul-10, Volume: 255, Issue:13

    Topics: Animals; Calcium; Carotid Arteries; Chlorpromazine; Egtazic Acid; Muscle Contraction; Muscle Relaxat

1980
Pharmacological characterisation of extracts of coffee dusts.
    British journal of industrial medicine, 1983, Volume: 40, Issue:2

    Topics: Animals; Coffee; Dose-Response Relationship, Drug; Dust; Female; Guinea Pigs; Histamine; In Vitro Te

1983
Human metabolism of 7-substituted theophyllines: N3-demethylation and lack of oxidation of proxyphylline.
    Journal of pharmaceutical sciences, 1981, Volume: 70, Issue:5

    Topics: Aminophylline; Animals; Biotransformation; Dealkylation; Guinea Pigs; Humans; In Vitro Techniques; I

1981
Effects of Freund's complete adjuvant and ovalbumin sensitization on the pharmacological reactivity of isolated guinea-pig trachea.
    International journal of immunopharmacology, 1982, Volume: 4, Issue:6

    Topics: Animals; Carbachol; Freund's Adjuvant; Guinea Pigs; Histamine; Immunization; In Vitro Techniques; Is

1982
Influence of tracheal contraction on relaxant effects in vitro of theophylline and isoprenaline.
    British journal of pharmacology, 1981, Volume: 74, Issue:1

    Topics: Airway Resistance; Animals; Carbachol; Drug Interactions; Female; Guinea Pigs; Hydrogen-Ion Concentr

1981
Quantitization of Ca spike frequency in a single sucrose gap and mechanical relaxation induced by Ca antagonists, isoproterenol and papaverine.
    Archives internationales de pharmacodynamie et de therapie, 1981, Volume: 252, Issue:1

    Topics: Action Potentials; Calcium; Calcium Channel Blockers; Humans; In Vitro Techniques; Isoproterenol; Ma

1981
Reactivity of isolated canine cerebral arteries to adenine nucleotides and adenosine.
    Pharmacology, 1980, Volume: 21, Issue:3

    Topics: Adenine Nucleotides; Adenosine; Animals; Cerebral Arteries; Dogs; Female; In Vitro Techniques; Male;

1980
Hydralazine: mode of action at the neuroarterial junction.
    Clinical science (London, England : 1979), 1980, Volume: 59 Suppl 6

    Topics: Animals; Arteries; Dose-Response Relationship, Drug; Hydralazine; Hypertension; In Vitro Techniques;

1980
Differential effects of ATP- and 2-methylthioATP-induced relaxation in guinea pig coronary vasculature.
    Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:5

    Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Coronary Vessels; Electrophysiology; Female; G

1994
Regulation of adenosine receptor function by theophylline in rat aorta.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:1

    Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic beta-Agonists; Animals; Aort

1994
Pharmacological analysis of the interaction between purinoceptor agonists and antagonists in the guinea-pig taenia caecum.
    British journal of pharmacology, 1995, Volume: 115, Issue:4

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cecum; Dipyridamole; Do

1995
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
    European journal of pharmacology, 1994, Aug-03, Volume: 270, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals;

1994
Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies.
    European journal of pharmacology, 1994, Sep-01, Volume: 262, Issue:1-2

    Topics: Animals; Arginine; Benzoates; Blood Pressure; Coronary Circulation; Cyclic N-Oxides; Dogs; Dose-Resp

1994
Characterization of adenosine receptors in the rat isolated aorta.
    General pharmacology, 1994, Volume: 25, Issue:7

    Topics: Adenosine; Animals; Aorta, Thoracic; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, V

1994
The role of cyclic AMP and phosphodiesterase activity in the mechanism of action of tetramethylpyrazine on human and dog cardiac and dog coronary arterial tissues.
    The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:11

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Action Potentials; Animals; Coronary Vessels; Cyclic AMP; Dogs;

1993
The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxamidoadenosine and N6-cyclopentyladenosine.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:3

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine; Endothelium, Vascular; Glyburide; I

1994
Cyclic nucleotide phosphodiesterase isoenzymes in guinea-pig tracheal muscle and bronchorelaxation by alkylxanthines.
    Biochemical pharmacology, 1994, Sep-15, Volume: 48, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Agonists; Albuterol; Animals; Bronchodilator Ag

1994
Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide.
    British journal of pharmacology, 1994, Volume: 111, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Capsaicin; Coronary Vessels; Endothelium, Vasc

1994
The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine.
    British journal of pharmacology, 1994, Volume: 111, Issue:3

    Topics: Animals; Caffeine; Calcium Chloride; Cold Temperature; Drug Interactions; Female; Guinea Pigs; Hista

1994
Subtypes of purinoceptors in rat and dog urinary bladder smooth muscles.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Acetylcholine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Dogs; Female; In V

1994
Effects of P1 and P2Y purinoceptor antagonists on endothelium-dependent and -independent relaxations of rat mesenteric artery to GTP and guanosine.
    British journal of pharmacology, 1994, Volume: 112, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Animals; Endothelium, Vascular; Guanosine; Guanosine Triphosphate

1994
ATP induced-relaxation in the mouse bladder smooth muscle.
    British journal of pharmacology, 1993, Volume: 108, Issue:3

    Topics: Adenosine Triphosphate; Animals; Calcium; Cytosol; Electric Stimulation; Fura-2; In Vitro Techniques

1993
Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells.
    Biochemical and biophysical research communications, 1994, Mar-15, Volume: 199, Issue:2

    Topics: Acetylcholine; Adenosine; Alkynes; Animals; Antihypertensive Agents; Aorta; Aorta, Thoracic; Base Se

1994
The effect of suramin on vasodilator responses to ATP and 2-methylthio-ATP in the Sprague-Dawley rat coronary vasculature.
    European journal of pharmacology, 1994, Jan-14, Volume: 251, Issue:2-3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Vessels; Drug Interactions; In Vitro Techniques

1994
Pharmacological actions of the coenzymes NAD(H) and NADP(H) on the rat anococcygeus muscle.
    Clinical and experimental pharmacology & physiology, 1994, Volume: 21, Issue:1

    Topics: Adenosine; Animals; Arginine; Electric Stimulation; Male; Muscle Contraction; Muscle Relaxation; NAD

1994
The nicardipine-isoprenaline interaction in human and guinea-pig isolated airways.
    Fundamental & clinical pharmacology, 1994, Volume: 8, Issue:1

    Topics: Adenosine; Animals; Bronchi; Colforsin; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pig

1994
Influence of aortic baroreceptor denervation on adenosine receptor-mediated relaxation of isolated rat aorta.
    European journal of pharmacology, 1994, Mar-11, Volume: 254, Issue:1-2

    Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta, Thoracic; Arginine; Blo

1994
A2-purinoceptor-mediated relaxation in the guinea-pig coronary vasculature: a role for nitric oxide.
    British journal of pharmacology, 1993, Volume: 109, Issue:2

    Topics: Adenosine; Animals; Antihypertensive Agents; Arginine; Coronary Vessels; Female; Guinea Pigs; In Vit

1993
Relaxant effects of nucleotides in guinea pig isolated, perfused trachea: lack of involvement of prostanoids, Cl- channels and adenosine.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:1

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo

1993
Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats.
    Experimental physiology, 1993, Volume: 78, Issue:3

    Topics: Actin Cytoskeleton; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Chlorides; Cy

1993
The relaxant actions on guinea-pig trachealis of atherosperminine isolated from Fissistigma glaucescens.
    European journal of pharmacology, 1993, Jun-11, Volume: 237, Issue:1

    Topics: Alkaloids; Animals; Benzopyrans; Calcium; Calmodulin; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP;

1993
Pharmacological activities of imidazo[1,2-alpha]pyrazine derivatives.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:12

    Topics: Adenosine; Animals; Calcium; Cardiovascular Agents; Cattle; Diuresis; Guinea Pigs; Heart Atria; Hear

1995
Blockade of acetylcholine release at the motor endplate by a polypeptide from the venom of Phoneutria nigriventer.
    British journal of pharmacology, 1995, Volume: 116, Issue:7

    Topics: Acetylcholine; Animals; Chickens; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Endpl

1995
Characterization of P1-purinoceptors on rat isolated duodenum longitudinal muscle and muscularis mucosae.
    British journal of pharmacology, 1996, Volume: 117, Issue:1

    Topics: Adenosine; Animals; Duodenum; Male; Muscle Relaxation; Muscle, Smooth; Rats; Receptors, Purinergic P

1996
A biphasic response to adenosine in the coronary vasculature of the K(+)-arrested perfused rat heart.
    European journal of pharmacology, 1996, Jun-20, Volume: 307, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Coronary Vessels; Hea

1996
Activation of multiple sites by adenosine analogues in the rat isolated aorta.
    British journal of pharmacology, 1996, Volume: 118, Issue:6

    Topics: Adenosine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques;

1996
ATP and beta,gamma-methylene ATP produce relaxation of guinea-pig isolated trachealis muscle via actions at P1 purinoceptors.
    European journal of pharmacology, 1996, Jun-27, Volume: 307, Issue:2

    Topics: Adenosine Triphosphate; Animals; Carbachol; Female; Guinea Pigs; In Vitro Techniques; Indomethacin;

1996
Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea pig isolated trachea.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Albuterol; Animals; Drug S

1996
Evidence that nitric oxide mediates non-adrenergic non-cholinergic relaxation induced by GABA and electrical stimulation in the rat isolated duodenum.
    Journal of autonomic pharmacology, 1996, Volume: 16, Issue:4

    Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; E

1996
A novel PACAP 1-27 analogue causes sustained smooth muscle relaxation in guinea-pig trachea.
    Annals of the New York Academy of Sciences, 1996, Dec-26, Volume: 805

    Topics: Albuterol; Animals; Bronchodilator Agents; Captopril; Glycopeptides; Guinea Pigs; In Vitro Technique

1996
Adenosine analogues relax guinea-pig taenia caeci via an adenosine A2B receptor and a xanthine-resistant site.
    European journal of pharmacology, 1997, Mar-26, Volume: 323, Issue:1

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cecum; Dose-Response Relationship, Drug; Guin

1997
P1-purinoceptor-mediated vasodilatation and vasoconstriction in hypoxia.
    Journal of autonomic pharmacology, 1996, Volume: 16, Issue:6

    Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Guinea Pigs; Hypoxia; In Vitro Techniques; In

1996
In vitro studies on the interactions of beta2-adrenoceptor agonists, methylxanthines, Ca2+-channel blockers, K+-channel openers and other airway smooth muscle relaxants in isolated guinea-pig trachea.
    European journal of pharmacology, 1997, May-20, Volume: 326, Issue:2-3

    Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Drug Interacti

1997
Effect of exogenous adenosine and its monophosphate on the contractile response to acetylcholine in the human isolated detrusor muscle strips.
    Journal of autonomic pharmacology, 1998, Volume: 18, Issue:2

    Topics: Acetylcholine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Adrenergic beta-Agonists;

1998
A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission.
    British journal of pharmacology, 1999, Volume: 126, Issue:4

    Topics: Adenosine; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals; Dose-Response Relatio

1999
Increased nitroglycerin-induced relaxation by genistein in rat aortic rings.
    European journal of pharmacology, 1999, Jul-21, Volume: 377, Issue:2-3

    Topics: Animals; Aorta; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors;

1999
The potentiating effect of genistein on the relaxation induced by isoproterenol in rat aortic rings.
    General pharmacology, 1999, Volume: 33, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Aorta; Benzoflavones; Bucladesine; Colforsin; Dose-Response Relat

1999
Comparison of the effects of selective III, IV and nonselective phosphodiesterase inhibitors on isolated tracheal preparations in streptozotocin-diabetic rats.
    Pharmacology, 2000, Volume: 60, Issue:1

    Topics: Amrinone; Animals; Carbachol; Cardiotonic Agents; Diabetes Mellitus, Experimental; Dose-Response Rel

2000
Nucleotide-evoked relaxation of rat vas deferens--a possible role for endogenous ATP released upon alpha(1)-adrenoceptor stimulation.
    European journal of pharmacology, 2001, Jun-22, Volume: 422, Issue:1-3

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apyrase; Dose-Response Relationship, Drug; I

2001
Pharmacologically induced relaxation of tracheal smooth muscle is increased in hyperoxia-exposed 15-day-old rats.
    Pediatric pulmonology, 2002, Volume: 33, Issue:2

    Topics: Adrenergic beta-Agonists; Albuterol; Animals; Animals, Newborn; Hyperoxia; Muscle Relaxation; Muscle

2002
Nucleotide-evoked relaxation of rat vas deferens: possible mechanisms.
    European journal of pharmacology, 2002, Feb-01, Volume: 436, Issue:1-2

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenosine; Adenosine Diphosphate; Adenosine Triphosp

2002
Gastric relaxation by apomorphine and ATP in the conscious dog.
    The Journal of pharmacy and pharmacology, 1979, Volume: 31, Issue:8

    Topics: Adenosine Triphosphate; Animals; Apomorphine; Dogs; Female; Muscle Contraction; Muscle Relaxation; M

1979
Analysis of the relationship between pharmacological inhibition of cyclic nucleotide phosphodiesterase and relaxation of canine tracheal smooth muscle.
    Biochemical pharmacology, 1979, Apr-15, Volume: 28, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase

1979
Urotensin I induced relaxation and intracellular cAMP content in the rat tail artery.
    Proceedings of the Western Pharmacology Society, 1977, Volume: 20

    Topics: Animals; Arteries; Cyclic AMP; Drug Interactions; Fishes; In Vitro Techniques; Male; Muscle Contract

1977
Effects of isoproterenol, theophylline and carbachol on cyclic nucleotide levels and relaxation of bovine tracheal smooth muscle.
    Biochimica et biophysica acta, 1977, Sep-29, Volume: 499, Issue:2

    Topics: Animals; Atropine; Carbachol; Cattle; Dose-Response Relationship, Drug; Isoproterenol; Muscle Relaxa

1977
Effects of isoprenaline on the time course of the cyclic AMP level in rat uterus.
    Acta pharmacologica et toxicologica, 1978, Volume: 42, Issue:5

    Topics: Adenosine; Animals; Catechols; Corticosterone; Cyclic AMP; Dipyridamole; Female; Guanosine Triphosph

1978
Apparent irrelevance of cyclic nucleotides to the relaxation of tracheal smooth muscle induced by theophylline.
    Lung, 1979, Volume: 156, Issue:3

    Topics: Animals; Calcium; Cyclic AMP; Cyclic GMP; Dogs; Guinea Pigs; Male; Muscle Contraction; Muscle Relaxa

1979
On the mechanism of relaxation of tracheal muscle by theophylline and other cyclic nucleotide phosphodiesterase inhibitors.
    Acta pharmacologica et toxicologica, 1979, Volume: 45, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Animals; Cyclic AMP; Cyclic GMP; Drug Interactions;

1979
Relaxation of guinea-pig fundic strip by adenosine, adenosine triphosphate and electrical stimulation: lack of antagonism by theophylline or ATP treatment.
    British journal of pharmacology, 1979, Volume: 67, Issue:2

    Topics: Adenosine; Adenosine Triphosphate; Animals; Electric Stimulation; Female; Guinea Pigs; In Vitro Tech

1979
Effects of prostaglandin E1 on isolated dog renal artery.
    Urology, 1979, Volume: 14, Issue:6

    Topics: Animals; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isoproteren

1979
Relaxations of guinea-pig fundic strip by adenosine, adenine nucleotides and electrical stimulation: antagonsism by theophylline and desensitization to adenosine and its derivatives.
    European journal of pharmacology, 1977, Dec-01, Volume: 46, Issue:3

    Topics: Adenine Nucleotides; Adenosine; Animals; Electric Stimulation; In Vitro Techniques; Male; Muscle Con

1977
The myorelaxant effect of theophylline on smooth muscle cells of the afferent arterioles and glomerular tuft.
    European journal of pharmacology, 1978, May-15, Volume: 49, Issue:2

    Topics: Animals; Arterioles; In Vitro Techniques; Kidney Glomerulus; Male; Muscle Contraction; Muscle Relaxa

1978
Relationship between theophylline-induced relaxation and excitation-contraction coupling in intestinal smooth muscle.
    Archives internationales de pharmacodynamie et de therapie, 1978, Volume: 232, Issue:2

    Topics: Action Potentials; Animals; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle R

1978
Relaxation of soman-induced contracture of airway smooth muscle in vitro.
    Drug and chemical toxicology, 1992, Volume: 15, Issue:3

    Topics: Acetylcholine; Adrenergic beta-Agonists; Albuterol; Animals; Colforsin; Dogs; Dose-Response Relation

1992
Theophylline produces over-additive relaxation of canine tracheal smooth muscle when combined with beta-agonists: the dose-response relationship.
    Pulmonary pharmacology, 1992, Volume: 5, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Epitheliu

1992
Role of potassium channels in bronchodilator responses in human airways.
    The American review of respiratory disease, 1992, Volume: 146, Issue:1

    Topics: Adolescent; Adult; Apamin; Benzopyrans; Bronchi; Bronchodilator Agents; Charybdotoxin; Child; Cromak

1992
Effect of compounds from Mandevilla velutina on bradykinin-mediated contractile and relaxant responses of the isolated guinea pig trachea.
    Agents and actions, 1992, Volume: 36, Issue:3-4

    Topics: Animals; Bradykinin; Carbachol; Dinoprost; Epithelial Cells; Epithelium; Female; Guinea Pigs; Histam

1992
Tracheal relaxation induced by potassium channel opening drugs: its antagonism by adrenergic neurone blocking agents.
    British journal of pharmacology, 1992, Volume: 106, Issue:4

    Topics: Adrenergic Antagonists; Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female;

1992
Inhibition by adrenergic neurone blocking agents of the relaxation induced by BRL 38227 in vascular, intestinal and uterine smooth muscle.
    British journal of pharmacology, 1992, Volume: 107, Issue:2

    Topics: Animals; Aorta, Thoracic; Benzopyrans; Bretylium Compounds; Cromakalim; Female; Guanethidine; Guinea

1992
The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:4

    Topics: Acetylcholine; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Drug Interactions; Histamine

1992
Pharmacological characterization of a new purinergic receptor site in rabbit aorta.
    General pharmacology, 1992, Volume: 23, Issue:6

    Topics: Adenosine; Adenosine Triphosphate; Animals; Aorta, Thoracic; In Vitro Techniques; Male; Muscle Relax

1992
Age-related changes in P2-purinergic receptors on vascular smooth muscle and endothelium.
    Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:3

    Topics: Adenosine Triphosphate; Aging; Animals; Aorta; Dose-Response Relationship, Drug; Endothelium, Vascul

1992
Influence of osmolarity of solutions used for K+ contraction on relaxant responses to pinacidil, verapamil, theophylline and terbutaline in isolated airway smooth muscle.
    Pharmacology & toxicology, 1992, Volume: 70, Issue:1

    Topics: Animals; Guanidines; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle

1992
On the purinergic system in rat duodenum: existence of P1 and P2 receptors on the smooth muscle.
    Archives internationales de physiologie et de biochimie, 1990, Volume: 98, Issue:1

    Topics: Adenosine Triphosphate; Animals; Duodenum; Electric Stimulation; In Vitro Techniques; Muscle Relaxat

1990
Leukotriene receptor antagonism and augmentation of beta-receptor-mediated events by LY171883.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:9

    Topics: 1-Methyl-3-isobutylxanthine; Acetophenones; Adrenergic beta-Agonists; Animals; Bronchodilator Agents

1990
Evidence that adenosine is not involved in the non-adrenergic non-cholinergic relaxation in the rat duodenum.
    Archives internationales de physiologie et de biochimie, 1990, Volume: 98, Issue:4

    Topics: Adenosine; Animals; Atropine; Duodenum; Electric Stimulation; Guanethidine; In Vitro Techniques; Iso

1990
Guinea-pig isolated trachealis: the effects of charybdotoxin on mechanical activity, membrane potential changes and the activity of plasmalemmal K(+)-channels.
    British journal of pharmacology, 1991, Volume: 103, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Benzopyrans; Calcium; Cell Membrane; Charybdotoxin; Cromakalim; G

1991
Relaxant effects of theophylline and clenbuterol on tracheal smooth muscle from horse and rat in vitro.
    Journal of veterinary pharmacology and therapeutics, 1991, Volume: 14, Issue:3

    Topics: Animals; Carbachol; Clenbuterol; Horses; Male; Muscle Relaxation; Muscle, Smooth; Rats; Rats, Inbred

1991
Role of the epithelium in airway smooth muscle responses to relaxant agonists.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 71, Issue:4

    Topics: Albuterol; Animals; Arachidonic Acid; Bronchodilator Agents; Diffusion; Epithelium; Guinea Pigs; In

1991
Direct effects of adenylyl 5'-(beta,gamma-methylene)diphosphonate, a stable ATP analogue, on relaxant P1-purinoceptors in smooth muscle.
    British journal of pharmacology, 1991, Volume: 104, Issue:3

    Topics: Adenosine; Adenosine Triphosphate; Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxatio

1991
Pharmacological effects of adenosine on canine penile erection.
    The Tohoku journal of experimental medicine, 1991, Volume: 165, Issue:1

    Topics: Acetylcholine; Adenosine; Animals; Blood Flow Velocity; Blood Pressure; Cavernous Sinus; Dipyridamol

1991
Dissociation between the effects of theophylline and caffeine on premature airway smooth muscles.
    Pediatric research, 1991, Volume: 29, Issue:5

    Topics: Acetylcholine; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Female; Humans; Infant,

1991
Isoproterenol activation of prostaglandin production in guinea-pig airway muscle preparations from immature and mature animals.
    Prostaglandins, 1991, Volume: 41, Issue:3

    Topics: Aging; Animals; Bronchi; Dinoprost; Dinoprostone; Enzyme Activation; Guinea Pigs; Histamine; Isoprot

1991
Peripheral type benzodiazepine receptors and response to adenosine on the guinea-pig isolated trachea.
    Pulmonary pharmacology, 1990, Volume: 3, Issue:3

    Topics: Adenosine; Animals; Benzodiazepines; Clonazepam; Diazepam; Dipyridamole; Drug Synergism; GABA-A Rece

1990
Effects of cularine and other isoquinoline alkaloids on guinea-pig trachea and human bronchus.
    The Journal of pharmacy and pharmacology, 1990, Volume: 42, Issue:2

    Topics: Adenosine; Alkaloids; Animals; Bronchi; Calcium; Guinea Pigs; Histamine; Humans; In Vitro Techniques

1990
Relaxant effects of adenosine analogs on guinea pig trachea in vitro: xanthine-sensitive and xanthine-insensitive mechanisms.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1

    Topics: Adenosine; Animals; Carbachol; Deoxyadenosines; Guinea Pigs; In Vitro Techniques; Male; Muscle Relax

1991
Effects of CGS-15943A on the relaxations produced by adenosine analogs in human blood vessels.
    European journal of pharmacology, 1990, Oct-23, Volume: 187, Issue:3

    Topics: Adenosine; Adult; Coronary Vessels; Humans; In Vitro Techniques; Mammary Arteries; Middle Aged; Musc

1990
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
    European journal of pharmacology, 1990, May-16, Volume: 180, Issue:2-3

    Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Te

1990
[The relaxation of the coronary artery smooth muscles under the action of a high-potassium solution].
    Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova, 1990, Volume: 76, Issue:1

    Topics: Animals; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Isotonic S

1990
Theophylline minimally alters contractile properties of canine diaphragm in vitro.
    Journal of applied physiology (Bethesda, Md. : 1985), 1990, Volume: 69, Issue:4

    Topics: Animals; Diaphragm; Diffusion; Dogs; Fatigue; In Vitro Techniques; Models, Biological; Muscle Contra

1990
Abnormalities in airway smooth muscle in fatal asthma.
    The American review of respiratory disease, 1990, Volume: 141, Issue:3

    Topics: Acetylcholine; Adult; Asthma; Cholinergic Fibers; Electric Stimulation; Female; Histamine; Humans; I

1990
Activities of caffeine, theophylline, and enprofylline analogs as tracheal relaxants.
    Biochemical pharmacology, 1990, Jun-15, Volume: 39, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Guinea Pigs; In Vitro Techniques; Male;

1990
Evaluation of the bronchodilator properties of Ro 31-6930, a novel potassium channel opener, in the guinea-pig.
    British journal of pharmacology, 1990, Volume: 100, Issue:2

    Topics: Albuterol; Anesthesia; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Decerebrate State; D

1990
Evidence that A2 purinoceptors are involved in endothelium-dependent relaxation of the rat thoracic aorta.
    British journal of pharmacology, 1990, Volume: 100, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Adenosine-5'-(N-ethylcarboxamide); Animals

1990
Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation.
    British journal of pharmacology, 1985, Volume: 85, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Bronchi; Bronchodilator Agents; Carbachol; Histamine; Humans; In

1985
Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung.
    British journal of pharmacology, 1989, Volume: 97, Issue:3

    Topics: Adult; Asthma; Autoradiography; Bronchi; Carbachol; Humans; In Vitro Techniques; Iodine Radioisotope

1989
Analysis of the relaxant effects of AH 21-132 in guinea-pig isolated trachealis.
    British journal of pharmacology, 1989, Volume: 97, Issue:4

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Acetylcholine; Animals; Female; Guinea Pigs; Histamine;

1989
Inhibitory effects of AH 21-132 in guinea-pig isolated ileum and taenia caeci.
    British journal of pharmacology, 1989, Volume: 97, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cecum; Electric S

1989
A possible mechanism of action of tetramethylpyrazine on vascular smooth muscle in rat aorta.
    European journal of pharmacology, 1989, Oct-10, Volume: 169, Issue:2-3

    Topics: Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Female; In Vitro Techniques

1989
Postnatal changes in response to adenosine and adenine nucleotides in rat duodenum.
    British journal of pharmacology, 1989, Volume: 97, Issue:4

    Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Animals; Animals, Newborn; Duodenum; Female;

1989
Apparent affinity of 1,3-dipropyl-8-cyclopentylxanthine for adenosine A1 and A2 receptors in isolated tissues from guinea-pigs.
    British journal of pharmacology, 1989, Volume: 97, Issue:4

    Topics: Adenosine; Animals; Aorta, Thoracic; Binding, Competitive; Guinea Pigs; Heart Rate; In Vitro Techniq

1989
Beta-adrenoceptor desensitization in guinea-pig isolated trachea.
    European journal of pharmacology, 1988, Nov-22, Volume: 157, Issue:2-3

    Topics: Animals; Autoradiography; Carbachol; Female; Fenoterol; Guinea Pigs; Hydrocortisone; In Vitro Techni

1988
Beta agonist-induced desensitization in pig bronchus.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Airway Resistance; Animals; Bronchi; Colforsi

1986
Fenspiride and relaxation of tracheobronchial musculature. Mechanism of action.
    Rhinology. Supplement, 1988, Volume: 4

    Topics: Animals; Bronchi; Guinea Pigs; Humans; Muscle Contraction; Muscle Relaxation; Spiro Compounds; Theop

1988
Different innervation mechanisms between the lesser and greater curvature of guinea pig antrum.
    Digestive diseases and sciences, 1989, Volume: 34, Issue:2

    Topics: Animals; Apamin; Atropine; Chymotrypsin; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Cont

1989
Further evidence for involvement of adenosine-5'-triphosphate in non-adrenergic non-cholinergic relaxation of the isolated rat duodenum.
    European journal of pharmacology, 1985, Jul-31, Volume: 113, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Autonomi

1985
[cAMP-dependent mechanism of relaxation of vascular smooth muscle cells in hypoxia not associated with decrease in the Ca2+ level in myoplasma].
    Doklady Akademii nauk SSSR, 1985, Volume: 285, Issue:5

    Topics: Calcium; Cyclic AMP; Humans; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Oxyge

1985
Calcium entry blocking activity of dilazep in dog coronary artery.
    Pharmacology, 1986, Volume: 33, Issue:3

    Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Arteries; Azepines; Calcium; Calcium Channel Block

1986
Relaxation of isolated corpus cavernosum induced by smooth-muscle relaxant drugs. A comparative study.
    Urological research, 1988, Volume: 16, Issue:4

    Topics: Adult; Aged; Humans; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle Relaxation;

1988
Involvement of P1-purinoreceptors in the relaxing effect of adenosine in rat duodenum.
    Journal of autonomic pharmacology, 1988, Volume: 8, Issue:2

    Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Duodenum; In Vitro Techniques; Male; Muscle Co

1988
New methylxanthine thio-derivatives inducing marked tracheal relaxation without increasing cardiac inotropism or motor activity.
    Pharmacological research communications, 1988, Volume: 20, Issue:7

    Topics: Animals; Caffeine; Guinea Pigs; In Vitro Techniques; Mice; Motor Activity; Muscle Relaxation; Muscle

1988
Slowing of relaxation in the fatiguing hamster diaphragm is enhanced by theophylline.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:3

    Topics: Animals; Caffeine; Calcium; Cricetinae; Diaphragm; In Vitro Techniques; Mesocricetus; Muscle Contrac

1988
Studies on alkyl-xanthine derivatives. II. Pharmacokinetic and pharmacodynamic studies of a new bronchodilator, 1-methyl-3-propylxanthine (MPX).
    Japanese journal of pharmacology, 1988, Volume: 48, Issue:3

    Topics: Animals; Bronchodilator Agents; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Rats; Rat

1988
Adenosine 5'-(2-fluorodiphosphate) is a selective agonist at P2-purinoceptors mediating relaxation of smooth muscle.
    European journal of pharmacology, 1988, Feb-16, Volume: 147, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aorta, Thoracic; Colon; Guinea Pigs; In Vitr

1988
The response of isolated guinea-pig aorta to amrinone.
    Journal of autonomic pharmacology, 1988, Volume: 8, Issue:1

    Topics: Adenosine; Adenosine Deaminase; Amrinone; Animals; Aorta, Thoracic; Female; Guinea Pigs; In Vitro Te

1988
Interaction of azelastine with adenosine receptors in guinea pig trachea.
    Agents and actions, 1988, Volume: 23, Issue:3-4

    Topics: Animals; Guinea Pigs; In Vitro Techniques; Male; Muscle Relaxation; Phenylisopropyladenosine; Phthal

1988
Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 290, Issue:2

    Topics: Female; Humans; In Vitro Techniques; Muscle Relaxation; Myometrium; Papaverine; Phosphodiesterase In

1987
Effects of adenosine and theophylline on canine tracheal smooth muscle tone.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 287, Issue:2

    Topics: Adenine; Adenosine; Animals; Dipyridamole; Dogs; Drug Interactions; In Vitro Techniques; Inosine; Ma

1987
The role of myogenic relaxation, adenosine and prostaglandins in human forearm reactive hyperaemia.
    The Journal of physiology, 1987, Volume: 389

    Topics: Adenosine; Adult; Arteries; Constriction; Female; Forearm; Humans; Ibuprofen; Male; Muscle Contracti

1987
Suppression by 5'-methylthioadenosine of histamine or leukotriene-induced contraction in isolated guinea pig tracheal rings.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt B

    Topics: Adenosine; Animals; Deoxyadenosines; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Hi

1986
Effects of theophylline on small human placental arteries in vitro.
    Acta pharmacologica et toxicologica, 1985, Volume: 56, Issue:1

    Topics: Dinoprost; Dinoprostone; Female; Humans; In Vitro Techniques; Muscle Contraction; Muscle Relaxation;

1985
Effect of calcium entry blockers and adenosine on the relaxation of large and small coronary arteries.
    Life sciences, 1986, Mar-10, Volume: 38, Issue:10

    Topics: Adenosine; Animals; Arteries; Calcium Channel Blockers; Cattle; Coronary Vessels; Dose-Response Rela

1986
Evidence that the intracellular effects of adenosine in the guinea-pig aorta are mediated by inosine.
    European journal of pharmacology, 1986, Feb-11, Volume: 121, Issue:1

    Topics: Adenosine; Animals; Aorta, Thoracic; Female; Guinea Pigs; In Vitro Techniques; Inosine; Male; Muscle

1986
Cellular Ca2+ monitored by aequorin in adenosine-mediated smooth muscle relaxation.
    The American journal of physiology, 1985, Volume: 248, Issue:1 Pt 2

    Topics: Adenosine; Aequorin; Animals; Body Fluids; Calcium; Dose-Response Relationship, Drug; Electric Stimu

1985
Effect of adenosine 5'triphosphate (ATP) on the isolated rectum of the rainbow lizard Agama agama.
    General pharmacology, 1985, Volume: 16, Issue:3

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Chloride; Carbachol; Dipyridamole; In Vitro Techni

1985