Page last updated: 2024-10-22

theophylline and Lung Neoplasms

theophylline has been researched along with Lung Neoplasms in 37 studies

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
" The current experiment has tested the hypothesis that green tea and the methylxanthine theophylline contained in tea inhibit the progression of neuroendocrine lung carcinogenesis in hamsters with hyperoxic lung injury and initiated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) while promoting the development of Clara cell-derived pulmonary adenocarcinomas initiated by NNK in healthy hamsters."7.72Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. ( Porter, B; Riechert, A; Schmoyer, R; Schuller, HM; Walker, K, 2004)
"Theophylline was absorbed rapidly in all subjects and within 2 h reached comparable peak concentrations in both groups (cancer patients: 57."6.67The disposition of theophylline in patients with lung and breast cancer. ( Attardo-Parrinello, G; Barzaghi, N; Corasaniti, MT; Crema, F; Gatti, G; Perucca, E, 1994)
" The current experiment has tested the hypothesis that green tea and the methylxanthine theophylline contained in tea inhibit the progression of neuroendocrine lung carcinogenesis in hamsters with hyperoxic lung injury and initiated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) while promoting the development of Clara cell-derived pulmonary adenocarcinomas initiated by NNK in healthy hamsters."3.72Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. ( Porter, B; Riechert, A; Schmoyer, R; Schuller, HM; Walker, K, 2004)
"Comparative investigation of subpopulations and functional properties of lymphocytes isolated from the tumour tissue (TTL) as well as of lymphocytes of the peripheral blood (PBL) of 11 lung cancer patients and 18 breast cancer patients has shown that an increase in the quantity of theophylline-sensitive cells (suppressors and killers) is characteristic of TTL."3.67[Comparative study of the lymphocyte surface receptors isolated from the blood and tissue of malignant tumors]. ( Bilynskiĭ, BT; Volod'ko, NA, 1986)
"Theophylline was absorbed rapidly in all subjects and within 2 h reached comparable peak concentrations in both groups (cancer patients: 57."2.67The disposition of theophylline in patients with lung and breast cancer. ( Attardo-Parrinello, G; Barzaghi, N; Corasaniti, MT; Crema, F; Gatti, G; Perucca, E, 1994)
"Lung cancer is the leading cause of cancer death in industrialized countries."1.31Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. ( Porter, B; Riechert, A; Schuller, HM, 2000)
"Theophylline-treated B16-F10 melanoma cells show a lower experimental metastatic potential in vivo."1.31Theophylline administration markedly reduces hepatic and pulmonary implantation of B16-F10 melanoma cells in mice. ( Abbruzzese, A; Beninati, S; Caraglia, M; Facchiano, F; Lentini, A; Vidal-Vanaclocha, F, 2000)
"Pre-treatment with motapizone, RP73401, rolipram or the methylxanthine adenosine receptor antagonist, 8-phenyltheophylline, did not significantly decrease responses to either allergen or LTC(4)."1.31The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways. ( Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N, 2000)
"Theophylline- and caffeine-treated B16-F10 cells exhibited low adhesion to laminin/collagen type IV and reduced invasion through Matrigel in an in vitro assay."1.30Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation. ( Abbruzzese, A; Autuori-Pezzoli, V; Beninati, S; Cardinali, M; Kleinman, HK; Lentini, A; Mattioli, P; Nicolini, L; Pietrini, A, 1998)
"The analysis of 178 cases of stage I-II breast cancer showed morphological features of local cell-mediated immune reactions to be of limited prognostic value."1.27[Local cellular immune reactions in cancer patients]. ( Bilynskiĭ, BT; Vasil'ev, NV; Volod'ko, NA, 1988)
"Metastasis is the principal cause of failures to cure human cancers."1.26Prostacyclin: a potent antimetastatic agent. ( Cicone, B; Honn, KV; Skoff, A, 1981)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199020 (54.05)18.7374
1990's5 (13.51)18.2507
2000's8 (21.62)29.6817
2010's2 (5.41)24.3611
2020's2 (5.41)2.80

Authors

AuthorsStudies
Shahzadi, I1
Parveen, B1
Ahmad, S1
Gul Khan, S1
Zahoor, AF1
Rasul, A1
Zahid, FM1
Eguchi, H1
Kimura, R1
Onuma, S1
Ito, A1
Yu, Y1
Yoshino, Y1
Matsunaga, T1
Endo, S1
Ikari, A1
Zhang, Y1
Wang, J1
Cheng, H1
Sun, Y1
Liu, M1
Wu, Z1
Pei, R1
Lentini, A3
Tabolacci, C1
Mattioli, P2
Provenzano, B1
Beninati, S3
BRENNIG, K1
HAGIWARA, T1
OKAYASU, D1
NAKAJIMA, S1
NISHIJIMA, T1
HEULIN, A1
SORS, C1
Schuller, HM3
Porter, B2
Riechert, A2
Walker, K1
Schmoyer, R1
Hirsh, L2
Dantes, A2
Suh, BS2
Yoshida, Y1
Hosokawa, K1
Tajima, K1
Kotsuji, F1
Merimsky, O2
Amsterdam, A2
Land-Bracha, A1
Hussein, A1
Al-Wadei, N1
Takahashi, T2
Malki, AM1
Gentry, J1
Evans, SC1
Janik, P1
Assaf, A1
Bertram, JS1
Flenley, DC1
Karpatkin, S1
Ambrogio, C1
Pearlstein, E1
Hainaut, J1
Devismes, D1
Nomura, T1
Honn, KV1
Cicone, B1
Skoff, A1
Corasaniti, MT1
Gatti, G1
Crema, F1
Attardo-Parrinello, G1
Barzaghi, N1
Perucca, E1
Entzian, P1
Barth, J1
Kodama, H1
Yoshida, I1
Ishikawa, S1
Ohtaki, A1
Satoh, Y1
Kawashima, O1
Morishita, Y1
Kleinman, HK1
Autuori-Pezzoli, V1
Nicolini, L1
Pietrini, A1
Abbruzzese, A2
Cardinali, M1
Vidal-Vanaclocha, F1
Facchiano, F1
Caraglia, M1
Schmidt, DT1
Watson, N1
Dent, G1
Rühlmann, E1
Branscheid, D1
Magnussen, H1
Rabe, KF1
Curtis-Prior, PB1
Gibbons, JR1
Chan, YH1
Giaccone, G1
Broers, J1
Jensen, S1
Fridman, RI1
Linnoila, R1
Gazdar, AF2
Skillrud, DM1
Moody, TW2
Carney, DN2
Korman, LY2
Minna, JD1
Citron, ML1
Bilynskiĭ, BT2
Vasil'ev, NV1
Volod'ko, NA2
Mosienko, MD1
Dorfman, MV1
Romashko, NI1
Wolberg, WH1
Williams, MH1
Güttner, J1
Horn, M1
Jungstand, W1
Malmberg, R1

Reviews

2 reviews available for theophylline and Lung Neoplasms

ArticleYear
[THERAPY OF CHRONIC BRONCHITIS].
    [Chiryo] [Therapy], 1964, Volume: 46

    Topics: Aerosols; Air Pollution; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyretics;

1964
Recent advances in respiratory medicine.
    Postgraduate medical journal, 1983, Volume: 59, Issue:687

    Topics: Adult; Aged; Anti-Bacterial Agents; Asthma; Bronchitis; Cephalosporins; Child; Humans; Immunosuppres

1983

Trials

1 trial available for theophylline and Lung Neoplasms

ArticleYear
The disposition of theophylline in patients with lung and breast cancer.
    Drugs under experimental and clinical research, 1994, Volume: 20, Issue:3

    Topics: Adult; Biotransformation; Breast Neoplasms; Female; Half-Life; Humans; Immunoenzyme Techniques; Inte

1994

Other Studies

34 other studies available for theophylline and Lung Neoplasms

ArticleYear
In-vitro cytotoxic evaluation, hemolytic and thrombolytic potential of newly designed acefylline based hydrazones as potent anticancer agents against human lung cancer cell line (A549).
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:3(Special)

    Topics: Antineoplastic Agents; Cell Line, Tumor; Hemolysis; Humans; Hydrazones; Lung Neoplasms; Structure-Ac

2022
Elevation of Anticancer Drug Toxicity by Caffeine in Spheroid Model of Human Lung Adenocarcinoma A549 Cells Mediated by Reduction in Claudin-2 and Nrf2 Expression.
    International journal of molecular sciences, 2022, Dec-07, Volume: 23, Issue:24

    Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Caffeine; Claudin-2; Doxorubicin; Humans;

2022
Conditional control of suicide gene expression in tumor cells with theophylline-responsive ribozyme.
    Gene therapy, 2017, Volume: 24, Issue:2

    Topics: A549 Cells; Bronchodilator Agents; Gene Expression Regulation, Enzymologic; Genes, Transgenic, Suici

2017
Antitumor activity of theophylline in combination with Paclitaxel: a preclinical study on melanoma experimental lung metastasis.
    Cancer biotherapy & radiopharmaceuticals, 2010, Volume: 25, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Pro

2010
[CLINICAL STUDIES WITH VOYAL IN RADIATION INJURIES].
    Wiener medizinische Wochenschrift (1946), 1963, Aug-31, Volume: 113

    Topics: Breast Neoplasms; Diphenhydramine; Female; Humans; Lung Neoplasms; Radiation Injuries; Theophylline;

1963
[CLINICAL STUDY OF A EUPNEIC AGENT: AMPLIPHYLLINE].
    Clinique (Paris, France), 1964, Volume: 59

    Topics: Asthma; Bronchiectasis; Bronchitis; Bronchodilator Agents; Dyspnea; Dyspnea, Paroxysmal; Humans; Lun

1964
Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers.
    Lung cancer (Amsterdam, Netherlands), 2004, Volume: 45, Issue:1

    Topics: Adenocarcinoma; Animals; Bronchodilator Agents; Cell Transformation, Neoplastic; Chemoprevention; Cr

2004
Phosphodiesterase inhibitors as anti-cancer drugs.
    Biochemical pharmacology, 2004, Sep-15, Volume: 68, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Drug Synergism; Female; Humans; Lung Neopl

2004
Induction of apoptosis in non-small lung carcinoma cell line (H1299) by combination of anti-asthma drugs with gemcitabine and cisplatin.
    International journal of oncology, 2005, Volume: 26, Issue:2

    Topics: Anti-Asthmatic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumo

2005
Theophylline stimulates cAMP-mediated signaling associated with growth regulation in human cells from pulmonary adenocarcinoma and small airway epithelia.
    International journal of oncology, 2005, Volume: 27, Issue:1

    Topics: Adenocarcinoma; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colforsin; Criceti

2005
Differential effect of selected methylxanthine derivatives on radiosensitization of lung carcinoma cells.
    Experimental oncology, 2006, Volume: 28, Issue:1

    Topics: Apoptosis; Caffeine; Carcinoma, Large Cell; Cell Line, Tumor; Cell Survival; Flow Cytometry; Gamma R

2006
Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine.
    Cancer research, 1980, Volume: 40, Issue:6

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Division; Female; Lung Neoplasms; Male; Mice; Neoplasm Me

1980
Lack of effect of in vivo prostacyclin on the development of pulmonary metastases in mice following intravenous injection of CT26 colon carcinoma, Lewis lung carcinoma, or B16 amelanotic melanoma cells.
    Cancer research, 1984, Volume: 44, Issue:9

    Topics: Animals; Cell Line; Colonic Neoplasms; Epoprostenol; Lung Neoplasms; Melanoma; Mice; Platelet Aggreg

1984
[Increase by the total dialysate leukocyte extract of E rosette formation in human theophylline treated lymphocytes].
    Comptes rendus des seances de l'Academie des sciences. Serie D, Sciences naturelles, 1980, Jan-07, Volume: 290, Issue:1

    Topics: Humans; Leukocytes; Lung Neoplasms; Lymphocytes; Rosette Formation; Theophylline; Tissue Extracts

1980
Comparative inhibiting effects of methylxanthines on urethan-induced tumors, malformations, and presumed somatic mutations in mice.
    Cancer research, 1983, Volume: 43, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Caffeine; DNA Repair; Lung Neoplasms; M

1983
Prostacyclin: a potent antimetastatic agent.
    Science (New York, N.Y.), 1981, Jun-12, Volume: 212, Issue:4500

    Topics: Animals; Antineoplastic Agents; Epoprostenol; Lung Neoplasms; Melanoma; Mice; Neoplasm Metastasis; N

1981
[Diagnostic errors in dyspnea].
    Zeitschrift fur arztliche Fortbildung, 1993, Apr-12, Volume: 87, Issue:5

    Topics: Adenocarcinoma, Mucinous; Adult; alpha 1-Antitrypsin Deficiency; Diagnostic Errors; Dyspnea; Heart F

1993
[Thoracotomy for patients with bronchial asthma].
    Rinsho kyobu geka = Japanese annals of thoracic surgery, 1994, Volume: 14, Issue:3

    Topics: Adult; Aminophylline; Anesthetics, Inhalation; Asthma; Blister; Bronchodilator Agents; Female; Human

1994
Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation.
    Melanoma research, 1998, Volume: 8, Issue:2

    Topics: Animals; Caffeine; Cell Adhesion; Cell Division; Collagen; Laminin; Lung Neoplasms; Male; Melanins;

1998
Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters.
    Journal of cancer research and clinical oncology, 2000, Volume: 126, Issue:11

    Topics: Adenocarcinoma; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carcinogens; Criceti

2000
Theophylline administration markedly reduces hepatic and pulmonary implantation of B16-F10 melanoma cells in mice.
    Melanoma research, 2000, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Melan

2000
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
    British journal of pharmacology, 2000, Volume: 131, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzam

2000
Cyclic nucleotide phosphodiesterase activity of human normal and carcinomatous lung tissue.
    Lancet (London, England), 1976, Dec-04, Volume: 2, Issue:7997

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Caffeine; Carcinoma, Squamous Cell; Cyclic AMP; Cyclic G

1976
Increased expression of differentiation markers can accompany laminin-induced attachment of small cell lung cancer cells.
    British journal of cancer, 1992, Volume: 66, Issue:3

    Topics: Acetamides; Actins; Bucladesine; Carcinoma, Small Cell; Cell Adhesion; Cell Differentiation; Cell Di

1992
COPD: causes, treatment, and risk for lung cancer.
    Comprehensive therapy, 1986, Volume: 12, Issue:11

    Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Combined Modality Therapy;

1986
Neurotensin is produced by and secreted from classic small cell lung cancer cells.
    Life sciences, 1985, May-06, Volume: 36, Issue:18

    Topics: Adenocarcinoma; Bucladesine; Carcinoma, Small Cell; Cell Line; Chromatography, Gel; Chromatography,

1985
Secretin/vasoactive intestinal peptide-stimulated secretion of bombesin/gastrin releasing peptide from human small cell carcinoma of the lung.
    Cancer research, 1986, Volume: 46, Issue:3

    Topics: Alprostadil; Bombesin; Bucladesine; Carcinoma, Small Cell; Cyclic AMP; Gastrin-Releasing Peptide; Hu

1986
[Local cellular immune reactions in cancer patients].
    Voprosy onkologii, 1988, Volume: 34, Issue:7

    Topics: Aged; Breast Neoplasms; Female; Humans; Lung Neoplasms; Lymphocytes; Middle Aged; Prognosis; Rosette

1988
[Active specific immunotherapy in patients with lung cancer following tumor removal].
    Voprosy onkologii, 1987, Volume: 33, Issue:3

    Topics: Adenocarcinoma; Adult; Aged; Antigens, Neoplasm; Carcinoma, Squamous Cell; Cell Separation; Combined

1987
[Comparative study of the lymphocyte surface receptors isolated from the blood and tissue of malignant tumors].
    Eksperimental'naia onkologiia, 1986, Volume: 8, Issue:3

    Topics: Adult; Aged; Breast Neoplasms; Humans; Lung Neoplasms; Lymphocytes; Middle Aged; Receptors, Immunolo

1986
Inhibition of leukocyte migration by human tumors. Effect on patient survival.
    Archives of surgery (Chicago, Ill. : 1960), 1974, Volume: 109, Issue:2

    Topics: Breast Neoplasms; Bucladesine; Cell Migration Inhibition; Colonic Neoplasms; Culture Media; Culture

1974
Special problems in respiratory diseases.
    Geriatrics, 1974, Volume: 29, Issue:6

    Topics: Adrenal Cortex Hormones; Aged; Aging; Anti-Bacterial Agents; Anticoagulants; Asthma; Bronchodilator

1974
[The oncogenicity of N-7-hydroxylated purine derivatives 7-hydroxy-theophylline].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:3

    Topics: Adenoma; Animals; Carcinogens; Female; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Mice;

1971
Respiratory insufficiency.
    Scandinavian journal of respiratory diseases. Supplementum, 1970, Volume: 72

    Topics: Adult; Bronchitis; Chronic Disease; Female; Follow-Up Studies; Humans; Lung Diseases; Lung Neoplasms

1970