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theophylline and Liver Neoplasms

theophylline has been researched along with Liver Neoplasms in 31 studies

Liver Neoplasms: Tumors or cancer of the LIVER.

Research Excerpts

ExcerptRelevanceReference
"Theophylline was absorbed rapidly in all subjects and within 2 h reached comparable peak concentrations in both groups (cancer patients: 57."6.67The disposition of theophylline in patients with lung and breast cancer. ( Attardo-Parrinello, G; Barzaghi, N; Corasaniti, MT; Crema, F; Gatti, G; Perucca, E, 1994)
" A total of 230 males were initially injected with diethylnitrosamine (200 mg/kg body weight, ip) or saline as controls and 2 wk later were fed on diet or drinking water supplemented as follows for 6 wk: 5% regular instant coffee; 5% decaffeinated instant coffee; freshly brewed coffee, 8 g in 140 ml water; 0."3.69Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. ( Hasegawa, R; Imaida, K; Ito, N; Ogiso, T; Shirai, T, 1995)
"The present study was undertaken to assess the adenosine receptor regulation of erythropoietin (Ep) secretion in hepatocellular carcinoma cells (Hep3B) in response to hypoxia."3.68[Increase in erythropoietin secretion mediated by adenosine A2 receptors]. ( Fisher, JW; Nakashima, J; Tazaki, H, 1993)
" On the other hand, 8-phenyltheophylline, an adenosine receptor antagonist, significantly inhibited the stimulatory effects of CHA on both Ep secretion and cAMP accumulation in the Hep 3B cell cultures in response to hypoxia."3.68Increased erythropoietin secretion in human hepatoma cells by N6-cyclohexyladenosine. ( Beckman, B; Brookins, J; Fisher, JW; Nakashima, J, 1991)
"Theophylline was absorbed rapidly in all subjects and within 2 h reached comparable peak concentrations in both groups (cancer patients: 57."2.67The disposition of theophylline in patients with lung and breast cancer. ( Attardo-Parrinello, G; Barzaghi, N; Corasaniti, MT; Crema, F; Gatti, G; Perucca, E, 1994)
"Theophylline-treated B16-F10 melanoma cells show a lower experimental metastatic potential in vivo."1.31Theophylline administration markedly reduces hepatic and pulmonary implantation of B16-F10 melanoma cells in mice. ( Abbruzzese, A; Beninati, S; Caraglia, M; Facchiano, F; Lentini, A; Vidal-Vanaclocha, F, 2000)
"In vitro cultures of an Epo producing hepatocellular carcinoma (Hep3B) cell line with NECA (> or = 10(-6) M) for 20 hours under hypoxic conditions (1% O2) produced significant increases in medium levels of Epo when compared with hypoxia controls."1.29Effects of 5'-N-ethylcarboxamideadenosine (NECA) on erythropoietin production. ( Agrawal, KC; Beckman, BS; Brookins, JW; Fisher, JW; Nakashima, J; Ohigashi, T, 1993)
"A 24h pretreatment of the human hepatoma cell line HepG2 with dibutyryl cyclic AMP in the presence of theophylline induced a dose dependent decrease in low density lipoprotein binding, uptake and degradation."1.27Cyclic AMP decreases LDL catabolism and cholesterol synthesis in the human hepatoma cell line HepG2. ( Auclair, M; Maziere, C; Maziere, JC; Mora, L; Moreau, M; Polonovski, J; Salmon, S, 1988)
"In a different type of hepatoma cell which is less malignant and forms a small tissue mass or island, cell surface ATPase activity at cell-cell contacts in an island is very weak or scarcely detected even when cells are not treated with dibutyryl cyclic AMP and theophylline."1.26Surface ATPase activity at cell-cell contacts in hepatic parenchymal cells and in cAMP-treated hepatoma cells in monolayer culture. ( Ohnishi, T; Yamaguchi, K, 1977)
"AH-66 rat ascites hepatoma cells incorporated [14C]leucine into the AFP fraction."1.25Synthesis of alpha-fetoprotein by rat ascites hepatoma cells. ( Endo, Y; Kanai, K; Kaneko, Y; Oda, T, 1975)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199021 (67.74)18.7374
1990's7 (22.58)18.2507
2000's3 (9.68)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gressner, OA1
Wu, LF1
Li, GP1
Feng, JL1
Pu, ZJ1
Barouski-Miller, PA1
Gelehrter, TD1
Suwanichkul, A1
DePaolis, LA1
Lee, PD1
Powell, DR1
Hasegawa, R1
Ogiso, T1
Imaida, K1
Shirai, T1
Ito, N1
Corasaniti, MT1
Gatti, G1
Crema, F1
Attardo-Parrinello, G1
Barzaghi, N1
Perucca, E1
Nakashima, J3
Ohigashi, T1
Brookins, JW1
Beckman, BS1
Agrawal, KC1
Fisher, JW3
Tazaki, H1
Lentini, A1
Vidal-Vanaclocha, F1
Facchiano, F1
Caraglia, M1
Abbruzzese, A1
Beninati, S1
Gopalakrishnan, TV1
Thompson, EB1
Kanai, K1
Endo, Y1
Oda, T1
Kaneko, Y1
Isaka, H1
Umehara, S1
Tsukada, Y1
Hickie, RA1
Walker, CM1
Datta, A1
Gunn, JM2
Tilghman, SM1
Hanson, RW2
Reshef, L2
Ballard, FJ2
Knowles, SE1
Castagna, M1
Boy, J1
Chauveau, J1
Flodrops, M1
Yamaguchi, K1
Ohnishi, T1
Wagner, K1
Roper, MD1
Leichtling, BH1
Wimalasena, J1
Wicks, WD1
Scratcherd, T1
Case, RM1
Smith, PA1
Brookins, J1
Beckman, B1
Ganapathi, MK1
Mackiewicz, A1
Samols, D1
Brabenec, A1
Kushner, I1
Schultz, D1
Hu, SI1
Maziere, C1
Maziere, JC1
Salmon, S1
Auclair, M1
Mora, L1
Moreau, M1
Polonovski, J1
Schröder, J1
Plagemann, PG2
Manganiello, V1
Vaughan, M1
Chayroth, R1
Epstein, S1
Field, JB1
Sheppard, JR1
Granner, D1
Chase, LR1
Aurbach, GD1
Tomkins, GM1
Reynolds, RD2
Scott, DF3
Potter, VR3
Morris, HP3
Butcher, FR1
Watanabe, M1

Reviews

1 review available for theophylline and Liver Neoplasms

ArticleYear
Less Smad2 is good for you! A scientific update on coffee's liver benefits.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:3

    Topics: Acetylgalactosamine; Animals; Caffeine; Carcinoma, Hepatocellular; Collagen Type I; Connective Tissu

2009

Trials

1 trial available for theophylline and Liver Neoplasms

ArticleYear
The disposition of theophylline in patients with lung and breast cancer.
    Drugs under experimental and clinical research, 1994, Volume: 20, Issue:3

    Topics: Adult; Biotransformation; Breast Neoplasms; Female; Half-Life; Humans; Immunoenzyme Techniques; Inte

1994

Other Studies

29 other studies available for theophylline and Liver Neoplasms

ArticleYear
Molecular mechanisms of adenosine-induced apoptosis in human HepG2 cells.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:4

    Topics: Adenosine; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Line, Tumor; Cell Prolife

2006
Paradoxical effects of glucocorticoids on regulation of plasminogen activator activity of rat hepatoma cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Cyclic AMP;

1982
Identification of a promoter element which participates in cAMP-stimulated expression of human insulin-like growth factor-binding protein-1.
    The Journal of biological chemistry, 1993, May-05, Volume: 268, Issue:13

    Topics: Base Sequence; Bucladesine; Carcinoma, Hepatocellular; Carrier Proteins; Cell Nucleus; Chloramphenic

1993
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1995, Volume: 33, Issue:1

    Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine;

1995
Effects of 5'-N-ethylcarboxamideadenosine (NECA) on erythropoietin production.
    Kidney international, 1993, Volume: 44, Issue:4

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carci

1993
[Increase in erythropoietin secretion mediated by adenosine A2 receptors].
    Human cell, 1993, Volume: 6, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Carcinoma, Hep

1993
Theophylline administration markedly reduces hepatic and pulmonary implantation of B16-F10 melanoma cells in mice.
    Melanoma research, 2000, Volume: 10, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Melan

2000
Effect of concanavalin A on tyrosine aminotransferase in rat hepatoma tissue culture cells. Rapid reversible inactivation of soluble enzyme.
    The Journal of biological chemistry, 1977, Apr-25, Volume: 252, Issue:8

    Topics: Alanine Transaminase; Animals; Carcinoma, Hepatocellular; Cell Line; Concanavalin A; Cyclic AMP; Cyc

1977
Synthesis of alpha-fetoprotein by rat ascites hepatoma cells.
    Annals of the New York Academy of Sciences, 1975, Aug-22, Volume: 259

    Topics: alpha-Fetoproteins; Animals; Bucladesine; Carcinoma, Hepatocellular; Fetal Proteins; Kinetics; Leuci

1975
Alpha-Fetoprotein synthesis in cultured cells: studies on Yoshida sarcoma and ascites hepatoma in vitro.
    Annals of the New York Academy of Sciences, 1975, Aug-22, Volume: 259

    Topics: Adenosine Monophosphate; alpha-Fetoproteins; Animals; Bucladesine; Butyrates; Carcinoma, Hepatocellu

1975
Increased activity of low-Km cyclic adenosine 3':5'-monophosphate phosphodiesterase in plasma membranes of Morris hepatoma 5123tc (h).
    Cancer research, 1975, Volume: 35, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Cell Fractionation; Cell Membrane; Cyclic AMP; Depression, Chemi

1975
Effects of cyclic adenosine monophosphate, dexamethasone and insulin on phosphoenolpyruvate carboxykinase synthesis in Reuber H-35 hepatoma cells.
    Biochemistry, 1975, Jun-03, Volume: 14, Issue:11

    Topics: Animals; Bucladesine; Carcinoma, Hepatocellular; Cells, Cultured; Dactinomycin; Deoxyadenosines; Dex

1975
Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues.
    The Biochemical journal, 1975, Volume: 146, Issue:3

    Topics: Amino Acids; Antibodies; Bucladesine; Canavanine; Carcinoma, Hepatocellular; Cell Line; Dexamethason

1975
[Effects of theophylline on chemically induced liver tumorogenesis and on bladder membranes in rats].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1975, Jun-16, Volume: 280, Issue:23

    Topics: Animals; Carcinoma, Hepatocellular; Depression, Chemical; Feeding Behavior; Liver Neoplasms; p-Dimet

1975
Surface ATPase activity at cell-cell contacts in hepatic parenchymal cells and in cAMP-treated hepatoma cells in monolayer culture.
    Histochemistry, 1977, Dec-07, Volume: 54, Issue:3

    Topics: Adenosine Triphosphatases; Bucladesine; Carcinoma, Hepatocellular; Cell Division; Cell Membrane; Cel

1977
Effects of 6- and 8-substituted analogs of adenosine 3':5'-monophosphate on phosphoenolpyruvate carboxykinase and tyrosine aminotransferase in hepatoma cell cultures.
    The Journal of biological chemistry, 1975, Jan-10, Volume: 250, Issue:1

    Topics: Animals; Butyrates; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Cyclic AMP; Cyclic G

1975
A sensitive method for the biological assay of secretin and substances with "secretin-like" activity in tissues and biological fluids.
    Scandinavian journal of gastroenterology, 1975, Volume: 10, Issue:8

    Topics: Adult; Animals; Biological Assay; Cats; Cholera; Diarrhea; Female; Humans; Intestinal Mucosa; Jejunu

1975
Increased erythropoietin secretion in human hepatoma cells by N6-cyclohexyladenosine.
    The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1

    Topics: Adenosine; Anaerobiosis; Bucladesine; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyclic AM

1991
Induction of C-reactive protein by cytokines in human hepatoma cell lines is potentiated by caffeine.
    The Biochemical journal, 1990, Jul-01, Volume: 269, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; C-Reactive Protein; Caffeine; Calcimycin; Calcium; Carcinoma

1990
Cyclic AMP decreases LDL catabolism and cholesterol synthesis in the human hepatoma cell line HepG2.
    Biochemical and biophysical research communications, 1988, Oct-14, Volume: 156, Issue:1

    Topics: Acetates; Acetic Acid; Bucladesine; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Cyclic AMP; H

1988
Cyclic 3',5'-nucleotide phosphodiesterases of Novikoff rat hepatoma, mouse L, and HeLa cells growing in suspension culture.
    Cancer research, 1972, Volume: 32, Issue:5

    Topics: Animals; Carcinoma, Hepatocellular; Cell Fractionation; Cells, Cultured; Cyclic AMP; HeLa Cells; In

1972
An effect of dexamethasone on adenosine 3',5'-monophosphate content and adenosine 3',5'-monophosphate phosphodiesterase activity of cultured hepatoma cells.
    The Journal of clinical investigation, 1972, Volume: 51, Issue:10

    Topics: Acid Phosphatase; Carcinoma, Hepatocellular; Cells, Cultured; Cyclic AMP; Dexamethasone; Epinephrine

1972
Increased cyclic AMP levels in malignant hepatic nodules of ethionine treated rats.
    Biochemical and biophysical research communications, 1972, Dec-18, Volume: 49, Issue:6

    Topics: Albumins; Anesthesia; Animals; Buffers; Carcinogens; Cyclic AMP; DNA; Ethionine; Liver; Liver Neopla

1972
Competitive inhibition of the transport of nucleosides, hypoxanthine, choline and deoxyglucose by theophylline, papaverine and prostaglandins.
    Biochemical and biophysical research communications, 1974, Feb-27, Volume: 56, Issue:4

    Topics: Animals; Binding, Competitive; Biological Transport, Active; Carcinoma, Hepatocellular; Cells, Cultu

1974
Tyrosine aminotransferase: enzyme induction independent of adenosine 3', 5'-monophosphate.
    Science (New York, N.Y.), 1968, Nov-29, Volume: 162, Issue:3857

    Topics: Adenine Nucleotides; Adenylyl Cyclases; Animals; Carcinoma, Hepatocellular; Culture Techniques; Cycl

1968
Further studies on the induction of tyrosine aminotransferase in Morris hepatoma 9618A.
    Advances in enzyme regulation, 1970, Volume: 9

    Topics: Amino Acids; Animals; Biological Transport; Carcinoma, Hepatocellular; Enzyme Induction; Glucagon; H

1970
Induction of tyrosine aminotransferase and amino acid transport in Morris hepatomas and in adult and neonatal rat liver.
    Cancer research, 1971, Volume: 31, Issue:11

    Topics: Amino Acids; Aminoisobutyric Acids; Animals; Animals, Newborn; Biological Transport; Carbon Isotopes

1971
Naturally occurring and induced levels of amino acid transport and tyrosine aminotransferase in rats bearing Morris hepatomas.
    Cancer research, 1972, Volume: 32, Issue:10

    Topics: Adrenal Glands; Adrenalectomy; Aminoisobutyric Acids; Animals; Biological Transport; Carbon Isotopes

1972
Hormonal effect on tyrosine aminotransferase activities in Yoshida sarcoma and its variant lines.
    Gan, 1972, Volume: 63, Issue:4

    Topics: Animals; Ascites; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cyclic AMP; Glucagon;

1972