theophylline has been researched along with B-Cell Chronic Lymphocytic Leukemia in 15 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The Eastern Cooperative Oncology Group (ECOG) performed a phase 2 study in B-cell chronic lymphocytic leukemia (CLL) of oral theophylline, a methylxanthine that inhibits cyclic nucleotide phosphodiesterases, thereby inducing the intracellular accumulation of cyclic adenosine monophosphate (cAMP)." | 5.11 | Phase II study of theophylline in chronic lymphocytic leukemia: a study of the Eastern Cooperative Oncology Group (E4998). ( Bennett, JM; Ghosh, C; Goloubeva, O; Kaminer, LS; Lee, SJ; Makower, D; Paietta, E; Pizzolo, J; Tallman, MS; Wade, JL; Wiernik, PH, 2004) |
| "), treated for ten years only by theophylline for bronchial asthma, we observed spontaneous apoptosis of B lymphocytes (10%)." | 3.69 | [In vitro induction of apoptosis in chronic lymphoid leukemia B lymphocytes by theophylline: therapeutic applications]. ( Baudet, S; Binet, JL; Mentz, F; Merle-Béral, H; Ouaaz, F, 1995) |
| "B-cell chronic lymphatic leukemia (B-CLL) has emerged as a prototype of malignancies characterized by a defective apoptosis that leads to a progressive accumulation of monoclonal B cells in the bone marrow, lymphoid tissues and peripheral blood." | 2.71 | Chlorambucil plus theophylline vs chlorambucil alone as a front line therapy for B-cell chronic lymphatic leukemia. ( Aref, S; El-Sharawy, S; Fouda, M; Mabed, M, 2004) |
| "Theophylline, a drug that has been used for several decades, has several different actions at a cellular level, including inhibition of phosphodiesterase isoenzymes, antagonism of adenosine, enhancement of catecholamine secretion, and modulation of calcium fluxes." | 2.40 | Theophylline: recent advances in the understanding of its mode of action and uses in clinical practice. ( Lipsky, JJ; Vassallo, R, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (60.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wiernik, PH | 2 |
| Paietta, E | 1 |
| Goloubeva, O | 1 |
| Lee, SJ | 1 |
| Makower, D | 2 |
| Bennett, JM | 1 |
| Wade, JL | 1 |
| Ghosh, C | 1 |
| Kaminer, LS | 1 |
| Pizzolo, J | 1 |
| Tallman, MS | 1 |
| Mabed, M | 1 |
| Aref, S | 1 |
| Fouda, M | 1 |
| El-Sharawy, S | 1 |
| Willis, CR | 1 |
| Goodrich, A | 1 |
| Park, K | 1 |
| Waselenko, JK | 1 |
| Lucas, M | 1 |
| Reese, A | 1 |
| Diehl, LF | 1 |
| Grever, MR | 1 |
| Byrd, JC | 1 |
| Flinn, IW | 1 |
| Mentz, F | 7 |
| Merle-Beral, H | 7 |
| Ouaaz, F | 3 |
| Binet, JL | 5 |
| Baudet, S | 4 |
| Leblond, V | 1 |
| Mossalayi, MD | 1 |
| Issaly, F | 2 |
| Ktorza, S | 1 |
| Semichon, M | 1 |
| Vassallo, R | 1 |
| Lipsky, JJ | 1 |
| Blanc, C | 1 |
| Maloum, K | 1 |
| Azgui, Z | 1 |
| Sevin, O | 1 |
| Vinsobre, MF | 1 |
| Dujarric, C | 1 |
| Brefort, K | 1 |
| Chretien, MC | 1 |
| Dalloul, AH | 1 |
| Malik, U | 1 |
| Novik, Y | 1 |
| Basu, S | 1 |
| Mitra Basu, R | 1 |
| Ural, AU | 1 |
| Lee, R | 1 |
| Wolda, S | 1 |
| Moon, E | 1 |
| Esselstyn, J | 1 |
| Hertel, C | 1 |
| Lerner, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of Theophylline in Chronic Lymphocytic Leukemia[NCT00003808] | Phase 2 | 0 participants | Interventional | 1999-08-11 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for theophylline and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Theophylline: recent advances in the understanding of its mode of action and uses in clinical practice.
Topics: Apnea; Apoptosis; Asthma; Calcium Channels; Capillary Leak Syndrome; Catecholamines; Erythropoietin; | 1998 |
3 trials available for theophylline and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Phase II study of theophylline in chronic lymphocytic leukemia: a study of the Eastern Cooperative Oncology Group (E4998).
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Apoptosis; B-Lymphocytes; bcl-2-Associated X P | 2004 |
Chlorambucil plus theophylline vs chlorambucil alone as a front line therapy for B-cell chronic lymphatic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Chlorambucil; Female; F | 2004 |
A phase I/II study examining pentostatin, chlorambucil, and theophylline in patients with relapsed chronic lymphocytic leukemia and non-Hodgkin's lymphoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Diseas | 2006 |
11 other studies available for theophylline and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Theophylline, a new inducer of apoptosis in B-CLL: role of cyclic nucleotides.
Topics: Aged; Apoptosis; B-Lymphocytes; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; Leukem | 1995 |
[In vitro induction of apoptosis in chronic lymphoid leukemia B lymphocytes by theophylline: therapeutic applications].
Topics: Aged; Antineoplastic Agents, Alkylating; Apoptosis; Asthma; B-Lymphocytes; Bronchodilator Agents; Ch | 1995 |
Synergistic action of alkylating agents and methylxanthine derivatives in the treatment of chronic lymphocytic leukemia.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyc | 1995 |
Theophylline synergizes with chlorambucil in inducing apoptosis of B-chronic lymphocytic leukemia cells.
Topics: Apoptosis; Calcium; Chlorambucil; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Gene | 1996 |
Simple, fast method of detection apoptosis in lymphoid cells.
Topics: Apoptosis; Blood Cell Count; Cells, Cultured; Chlorambucil; Flow Cytometry; Humans; Immunohistochemi | 1998 |
Quantification of apoptosis by the Abbott CD4000 hematology analyzer.
Topics: Apoptosis; Autoanalysis; Cells, Cultured; Female; Flow Cytometry; Hematology; Humans; Immunohistoche | 1998 |
Theophylline-induced B-CLL apoptosis is partly dependent on cyclic AMP production but independent of CD38 expression and endogenous IL-10 production.
Topics: ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Antigens, CD; Antigens, Differentiation; Apoptosis; B-Ly | 1999 |
Therapeutic efficacy of theophylline in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Apoptosis; Cyclic AMP; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell | 1999 |
Theophylline as a therapy for chronic lymphocytic leukemia: a case report and review of literature.
Topics: Aged; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphodiesterase Inhibitors; Theophyl | 2000 |
Combination chemotherapy with theophylline in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Drug Therapy, Combination; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Ph | 2001 |
PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; B-Lymphocytes; Cells, Cultured; Co | 2002 |