theophylline has been researched along with Lesch-Nyhan Syndrome in 3 studies
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lesch-Nyhan syndrome involves disorders of both purine and dopamine metabolism." | 3.67 | Assessment of purine-dopamine interactions in 6-hydroxydopamine-lesioned rats: evidence for pre- and postsynaptic influences by adenosine. ( Breese, GR; Criswell, H; Mueller, RA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferrer, I | 1 |
| Costell, M | 1 |
| Grisolía, S | 1 |
| Criswell, H | 1 |
| Mueller, RA | 1 |
| Breese, GR | 1 |
| Sakata, T | 1 |
| Fuchimoto, H | 1 |
3 other studies available for theophylline and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Lesch-Nyhan syndrome-like behavior in rats from caffeine ingestion: changes in HGPRTase activity, urea and some nitrogen metabolism enzymes.
Topics: Acetylcholinesterase; Animals; Aspartate Carbamoyltransferase; Brain; Caffeine; Carbamoyl-Phosphate | 1982 |
Assessment of purine-dopamine interactions in 6-hydroxydopamine-lesioned rats: evidence for pre- and postsynaptic influences by adenosine.
Topics: Adenosine; Animals; Female; Hydroxydopamines; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Sy | 1988 |
[Abnormal behavior caused by methylxanthines: a study of experimental Lesch-nyhman syndrome].
Topics: Animals; Behavior, Animal; Cyclic AMP; Humans; Lesch-Nyhan Syndrome; Purines; Rats; Theophylline; Xa | 1973 |