Page last updated: 2024-10-22

theophylline and Kidney Failure

theophylline has been researched along with Kidney Failure in 14 studies

Kidney Failure: A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism.

Research Excerpts

ExcerptRelevanceReference
"Those infants with asphyxial renal failure were followed up for 1 year."2.72Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. ( Bhat, MA; Makhdoomi, MS; Mufti, MH; Shah, ZA, 2006)
" Cefaclor is not metabolized to a significant degree, but it degrades chemically in the body with an approximate half-life of 2 hours."2.40Pharmacokinetic profile of cefaclor. ( Derendorf, H; Schifferer, H; Sourgens, H, 1997)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's2 (14.29)18.2507
2000's6 (42.86)29.6817
2010's5 (35.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aydin, M1
Hakan, N1
Zenciroglu, A1
Okumus, N1
Al-Wassia, H2
Raina, A1
Pandita, A1
Harish, R1
Yachha, M1
Jamwal, A1
Huber, W1
Huber, T1
Baum, S1
Franzen, M1
Schmidt, C1
Stadlbauer, T1
Beitz, A1
Schmid, RM1
Schmid, S1
Efrati, S1
Berman, S1
Ilgiyeav, I1
Siman-Tov, Y1
Averbukh, Z1
Weissgarten, J1
Eslami, Z1
Shajari, A1
Kheirandish, M1
Heidary, A1
Alshaikh, B1
Sauve, R1
BAUER, KM1
Misawa, D1
Ohshima, K1
Watanabe, M1
Asai, K1
Ino, T1
Ueda, M1
Bhat, MA1
Shah, ZA1
Makhdoomi, MS1
Mufti, MH1
Ming, Z1
Fan, YJ1
Yang, X1
Lautt, WW1
Barrett, RJ1
Sourgens, H1
Derendorf, H1
Schifferer, H1
Katholi, RE1
Taylor, GJ1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Aminophylline on Preventing Acute Kidney Injury in Pediatric Patients Undergoing Open Heart Surgery[NCT03897335]Phase 380 participants (Anticipated)Interventional2019-02-07Recruiting
[NCT02276170]9 participants (Actual)Observational2014-10-31Terminated (stopped due to insufficient rate of accrual)
Perioperative Aminophylline to Improve High Risk Renal Graft Outcome- a Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT01759862]50 participants (Actual)Interventional2012-11-30Completed
A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia Plus Magnesium Sulphate (MgSO4) Versus Therapeutic Hypothermia Plus Placebo in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy[NCT01646619]Phase 3300 participants (Anticipated)Interventional2012-05-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Calculated Estimated Glomerular Filtration Rate (eGFR)

The investigators will measure blood creatinine on post-operative day 5 and using the Schwartz equation will calculate estimated glomerular filtration rate (GFR) to determine kidney function. (NCT01759862)
Timeframe: 5 days

Interventionml/min/1.73m2 (Mean)
Aminophylline67.39
Control80.48

Presence of Fibrosis Measured on Protocol Biopsy

The investigators will use the same cores that are obtained during routine 6 months protocol biopsies to quantify the amount of fibrosis (NCT01759862)
Timeframe: 6 months

InterventionParticipants (Count of Participants)
Aminophylline11
Control14

Urinary NGAL (Neutrophil Gelatinase-associated Lipocalin)/ Creatinine Ratio

urinary NGAL(Neutrophil gelatinase-associated lipocalin) is a biomarker for kidney injury. NGAL levels 12h post-transplant were found to be a marker for development of delayed graft function and need for dialysis post-transplant. NGAL levels are corrected for urine creatinine. (NCT01759862)
Timeframe: 12 hours post transplant

Interventionng/mg (Median)
Aminophylline300.5
Control425.4

Reviews

3 reviews available for theophylline and Kidney Failure

ArticleYear
Prophylactic theophylline for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia: a systematic review and meta-analysis of randomized controlled trials.
    Journal of perinatology : official journal of the California Perinatal Association, 2013, Volume: 33, Issue:4

    Topics: Asphyxia Neonatorum; Glomerular Filtration Rate; Humans; Infant, Newborn; Infant, Postmature; Intens

2013
Realizing the potential of adenosine-receptor-based therapeutics.
    Proceedings of the Western Pharmacology Society, 1996, Volume: 39

    Topics: Adenine; Animals; Clinical Trials as Topic; Humans; Norbornanes; Pain; Purinergic P1 Receptor Agonis

1996
Pharmacokinetic profile of cefaclor.
    International journal of clinical pharmacology and therapeutics, 1997, Volume: 35, Issue:9

    Topics: Aged; Antacids; Area Under Curve; Cefaclor; Cephalosporins; Child; Cimetidine; Drug Interactions; Ha

1997

Trials

4 trials available for theophylline and Kidney Failure

ArticleYear
Treating perinatal asphyxia with theophylline at birth helps to reduce the severity of renal dysfunction in term neonates.
    Acta paediatrica (Oslo, Norway : 1992), 2016, Volume: 105, Issue:10

    Topics: Asphyxia Neonatorum; Humans; Infant, Newborn; Renal Insufficiency; Theophylline; Vasodilator Agents

2016
Sodium Bicarbonate Prevents Contrast-Induced Nephropathy in Addition to Theophylline: A Randomized Controlled Trial.
    Medicine, 2016, Volume: 95, Issue:21

    Topics: Aged; Aged, 80 and over; Contrast Media; Creatinine; Double-Blind Method; Drug Therapy, Combination;

2016
Theophylline for prevention of kidney dysfunction in neonates with severe asphyxia.
    Iranian journal of kidney diseases, 2009, Volume: 3, Issue:4

    Topics: Asphyxia Neonatorum; Cohort Studies; Creatinine; Female; Glomerular Filtration Rate; Humans; Infant,

2009
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
    The Journal of pediatrics, 2006, Volume: 149, Issue:2

    Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma

2006

Other Studies

7 other studies available for theophylline and Kidney Failure

ArticleYear
Is the use of prophylactic theophylline safe for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia?
    Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:1

    Topics: Asphyxia Neonatorum; Humans; Infant, Postmature; Renal Insufficiency; Theophylline

2014
Reply to: 'Is the use of prophylactic theophylline safe for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia?'.
    Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:1

    Topics: Asphyxia Neonatorum; Humans; Infant, Postmature; Renal Insufficiency; Theophylline

2014
Differential effects of N-acetylcysteine, theophylline or bicarbonate on contrast-induced rat renal vasoconstriction.
    American journal of nephrology, 2009, Volume: 29, Issue:3

    Topics: Acetylcysteine; Animals; Contrast Media; Dinoprostone; Free Radical Scavengers; Hypoxia; Iothalamic

2009
[Clinical experience with a new theophylline derivative combined with a new spasmolytic in the treatment of renal insufficiency].
    Die Medizinische, 1957, Mar-02, Issue:9

    Topics: Cardiovascular Agents; Kidney Diseases; Muscle Relaxants, Central; Parasympatholytics; Renal Insuffi

1957
[Rhabdomyolysis: case report of 11 patients].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2005, Jul-10, Volume: 94, Issue:7

    Topics: Adult; Aged; Enteritis; Female; Humans; Hypokinesia; Influenza A virus; Influenza, Human; Male; Midd

2005
Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats.
    Hepatology (Baltimore, Md.), 2006, Volume: 44, Issue:4

    Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Chemical and Drug Ind

2006
Renal effect of low-dose dopamine in high-risk patients undergoing coronary angiography.
    Journal of the American College of Cardiology, 2000, Volume: 36, Issue:1

    Topics: Animals; Cardiotonic Agents; Coronary Angiography; Coronary Disease; Dopamine; Dose-Response Relatio

2000