theophylline has been researched along with Innate Inflammatory Response in 67 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "One of the important modes of action of theophylline in asthma and chronic obstructive airway disease may be the inhibition of airway inflammation." | 10.16 | The effects of theophylline on airway inflammation. ( Pauwels, R, 1987) |
| "Thus, in the theophylline-administered group, slow-release theophylline, Theolong, was effective in treating asthma, with anti-inflammatory effects on inflammatory cells besides its bronchodilator action." | 9.09 | Suppression of airway inflammation by theophylline in adult bronchial asthma. ( Doi, M; Hirose, M; Horiguchi, T; Imazu, M; Kasahara, J; Miyazaki, J; Sasaki, Y; Shiga, M; Tachikawa, S, 1999) |
| "1 To investigate the effect of moderate hypoxia alone or combined with an inflammatory reaction or after 3-methylcholanthrene (3MC) pre-treatment on cytochrome P450 (P450), conscious rabbits were exposed for 24 h to a fractional concentration of inspired O2 of 10% (mean PaO2 of 34 mmHg)." | 7.70 | Effect of hypoxia alone or combined with inflammation and 3-methylcholanthrene on hepatic cytochrome P450 in conscious rabbits. ( Bélanger, PM; Dalkara, S; El-Kadi, AO; Kurdi, J; Maurice, H; Ong, H; Souich, P, 1999) |
| "This study was performed to assess whether nifedipine could prevent the decrease in hepatic cytochrome P450 induced by acute moderate hypoxia or an inflammatory reaction." | 7.69 | Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction. ( Barakat, M; du Souich, P, 1996) |
| "Cromolyn sodium has matured as a first-line drug in the management of asthma in the United States." | 7.67 | Cromolyn sodium in the treatment of asthma: coming of age in the United States. ( Bernstein, IL, 1985) |
| "Bronchial asthma is eosinophilic airway inflammation with enhanced airway responsiveness induced by eosinophilic granule proteins such as eosinophilic cationic protein (ECP) that are released from eosinophils." | 6.70 | [Effects of once-daily low-dose administration of sustained-release theophylline on airway inflammation and airway hyperresponsiveness in patients with asthma]. ( Terao, I, 2002) |
| "Chronic obstructive pulmonary disease (COPD) has become a global epidemic disease with an increased morbidity and mortality in the world." | 6.48 | Can β2-adrenoceptor agonists, anticholinergic drugs, and theophylline contribute to the control of pulmonary inflammation and emphysema in COPD? ( Advenier, C; Bureau, F; Cambier, C; Cui, YY; Devillier, P; Gustin, P; Rong, WF; Zhang, WH; Zhang, Y, 2012) |
| "One of the important modes of action of theophylline in asthma and chronic obstructive airway disease may be the inhibition of airway inflammation." | 6.16 | The effects of theophylline on airway inflammation. ( Pauwels, R, 1987) |
| "Theophylline has an anti-inflammatory role in COPD." | 5.51 | Theophylline inhibits cigarette smoke-induced inflammation in skeletal muscle by upregulating HDAC2 expression and decreasing NF-κB activation. ( Bai, J; Bin, Y; He, Z; Huang, D; Liang, Q; Liang, Y; Ma, Z; Xiao, Y; Zhang, J; Zhang, W; Zhong, X, 2019) |
| "Theophylline has been used for decades in the treatment of chronic inflammatory airway diseases." | 5.43 | Bronchodilator and Anti-Inflammatory Action of Theophylline in a Model of Ovalbumin-Induced Allergic Inflammation. ( Kertys, M; Kosutova, P; Mikolka, P; Mokra, D; Mokry, J; Simekova, M; Urbanova, A, 2016) |
| "Thus, in the theophylline-administered group, slow-release theophylline, Theolong, was effective in treating asthma, with anti-inflammatory effects on inflammatory cells besides its bronchodilator action." | 5.09 | Suppression of airway inflammation by theophylline in adult bronchial asthma. ( Doi, M; Hirose, M; Horiguchi, T; Imazu, M; Kasahara, J; Miyazaki, J; Sasaki, Y; Shiga, M; Tachikawa, S, 1999) |
| " Natural products have been a rich source of drug discovery, Theophylline and Methylxanthine originated from tea leaves used for asthma treatment, whereas, Papaverine, a natural isoquinolein originated from Papaver somniferum traditionally used in impotency, altogether as caffeine where firstly described as PDE-inhibiting compounds." | 4.95 | Therapeutic potentials of natural compounds acting on cyclic nucleotide phosphodiesterase families. ( Abusnina, A; Lugnier, C, 2017) |
| " We evaluated the relationship between TNF-alpha and iNOS expression in indomethacin-induced jejunoileitis in male Sprague-Dawley rats." | 3.73 | Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression. ( Finocchiaro, S; Levine, RA; Nandi, J; Ong, G; Saud, B, 2005) |
| "1 To investigate the effect of moderate hypoxia alone or combined with an inflammatory reaction or after 3-methylcholanthrene (3MC) pre-treatment on cytochrome P450 (P450), conscious rabbits were exposed for 24 h to a fractional concentration of inspired O2 of 10% (mean PaO2 of 34 mmHg)." | 3.70 | Effect of hypoxia alone or combined with inflammation and 3-methylcholanthrene on hepatic cytochrome P450 in conscious rabbits. ( Bélanger, PM; Dalkara, S; El-Kadi, AO; Kurdi, J; Maurice, H; Ong, H; Souich, P, 1999) |
| "A new guinea pig model of allergic asthma was used to investigate the effects of low doses of the phosphodiesterase inhibitors, rolipram (phosphodiesterase IV selective), ORG 20241 (N-hydroxy-4-(3,4-dimethoxyphenyl)-thiazole-2-carboximidamide; dual phosphodiesterase III/IV inhibitor with some selectivity for the phosphodiesterase IV isoenzyme), and of theophylline (non-selective) on allergen-induced early and late phase asthmatic reactions, bronchial hyperreactivity to histamine inhalation, and airway inflammation." | 3.69 | Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs. ( Meurs, H; Olymulder, CG; Santing, RE; Van der Molen, K; Zaagsma, J, 1995) |
| "This study was performed to assess whether nifedipine could prevent the decrease in hepatic cytochrome P450 induced by acute moderate hypoxia or an inflammatory reaction." | 3.69 | Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction. ( Barakat, M; du Souich, P, 1996) |
| "Cromolyn sodium has matured as a first-line drug in the management of asthma in the United States." | 3.67 | Cromolyn sodium in the treatment of asthma: coming of age in the United States. ( Bernstein, IL, 1985) |
| "COPD is characterized by chronic inflammation." | 2.82 | Oral Low-dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients With Severe COPD: A Pilot Clinical Trial. ( Agusti, A; Barnes, PJ; Córdova, R; Cosío, BG; Gea, J; Iglesias, A; Palou, A; Pascual, S; Peces-Barba, G; Rodriguez-Roisin, R; Shafiek, H; Sibila, O; Yanez, A, 2016) |
| "Forty stable COPD patients (group C) were randomized into a subgroup receiving oral theophylline 0." | 2.71 | [Changes of leukotriene B4 in induced sputum and plasma of patients with chronic obstructive pulmonary disease and the effects of theophylline]. ( Ding, YL; Liu, Z; Wang, YZ; Yao, WZ, 2005) |
| "Bronchial asthma is eosinophilic airway inflammation with enhanced airway responsiveness induced by eosinophilic granule proteins such as eosinophilic cationic protein (ECP) that are released from eosinophils." | 2.70 | [Effects of once-daily low-dose administration of sustained-release theophylline on airway inflammation and airway hyperresponsiveness in patients with asthma]. ( Terao, I, 2002) |
| "Inflammation is a central feature of asthma and chronic obstructive pulmonary disease (COPD)." | 2.61 | Transcription inhibitors and inflammatory cell activity. ( Adcock, IM; Cannavò, MF; Caramori, G; Coppolino, I; Mumby, S; Nucera, F; Proietto, A; Ruggeri, P, 2019) |
| "Chronic obstructive pulmonary disease (COPD) has become a global epidemic disease with an increased morbidity and mortality in the world." | 2.48 | Can β2-adrenoceptor agonists, anticholinergic drugs, and theophylline contribute to the control of pulmonary inflammation and emphysema in COPD? ( Advenier, C; Bureau, F; Cambier, C; Cui, YY; Devillier, P; Gustin, P; Rong, WF; Zhang, WH; Zhang, Y, 2012) |
| "The inflammation is resistant to steroids, and it is believed that there may be a defect in the anti-inflammatory effects of these drugs in COPD." | 2.45 | [The pathogenesis of chronic obstructive pulmonary disease, steroid resistance and the place of theophylline in the treatment]. ( Bayram, H, 2009) |
| "Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible." | 2.43 | [Pharmacological treatment of COPD and future of anti-inflammatory therapy]. ( Bitter-Suermann, S; Kanniess, F; Magnussen, H; Watz, H, 2006) |
| "Theophylline, a drug which has been used in asthma therapy for many years, provides additional benefit for patients already treated with effective doses of beta-agonists and/or corticosteroids." | 2.38 | Asthma--something old, something new .... ( Milgrom, H, 1991) |
| "Doxofylline was shown to improve ventilation and air exchange during mechanical ventilation in rats with COPD, reduce the inflammatory response and oxidative stress, and mitigate the degree of pulmonary tissue injury." | 1.72 | Effect of doxofylline on pulmonary inflammatory response and oxidative stress during mechanical ventilation in rats with COPD. ( Chen, ZY; Chu, SQ; Li, Y; Lin, YM; Wu, JH; Xie, WX; Zhang, XQ; Zhang, Y, 2022) |
| "Theophylline has an anti-inflammatory role in COPD." | 1.51 | Theophylline inhibits cigarette smoke-induced inflammation in skeletal muscle by upregulating HDAC2 expression and decreasing NF-κB activation. ( Bai, J; Bin, Y; He, Z; Huang, D; Liang, Q; Liang, Y; Ma, Z; Xiao, Y; Zhang, J; Zhang, W; Zhong, X, 2019) |
| "Theophylline is a natural compound present in tea." | 1.46 | Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach. ( Cannataro, R; D'Agostino, B; Falcone, D; Gallelli, L; Maselli, R; Pelaia, G; Perri, M; Savino, R; Serra, R; Spaziano, G, 2017) |
| "Theophylline has been used for decades in the treatment of chronic inflammatory airway diseases." | 1.43 | Bronchodilator and Anti-Inflammatory Action of Theophylline in a Model of Ovalbumin-Induced Allergic Inflammation. ( Kertys, M; Kosutova, P; Mikolka, P; Mokra, D; Mokry, J; Simekova, M; Urbanova, A, 2016) |
| "Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder partially resistant to glucocorticoids." | 1.42 | Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD. ( Agustí, A; Busquets, X; Cosío, BG; Iglesias, A; Jahn, A; Shafiek, H, 2015) |
| "Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease of the lungs with little or no response to glucocorticoids and a high level of oxidative stress." | 1.32 | Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. ( Adcock, IM; Barnes, PJ; Cosio, BG; Ito, K; Jazrawi, E; Tsaprouni, L, 2004) |
| "Pulmonary inflammation was induced in adult Wistar rats by a 60-min exposure to endotoxin (lipopolysaccharide, LPS, 100 micrograms/mL)." | 1.30 | Effects of interleukin-10 and modulators of cyclic AMP formation on endotoxin-induced inflammation in rat lung. ( Boichot, E; Escofier, N; Germain, N; Lagente, V; Martins, MA; Silva, PM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (20.90) | 18.7374 |
| 1990's | 17 (25.37) | 18.2507 |
| 2000's | 16 (23.88) | 29.6817 |
| 2010's | 16 (23.88) | 24.3611 |
| 2020's | 4 (5.97) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Azimi, AS | 1 |
| Soleimani Mehranjani, M | 1 |
| Shariatzadeh, SMA | 1 |
| Noshad Kamran, A | 1 |
| Ghafarizadeh, AA | 1 |
| Chen, ZY | 1 |
| Lin, YM | 1 |
| Wu, JH | 1 |
| Zhang, XQ | 1 |
| Zhang, Y | 2 |
| Xie, WX | 1 |
| Chu, SQ | 1 |
| Li, Y | 1 |
| Talmon, M | 1 |
| Massara, E | 1 |
| Brunini, C | 1 |
| Fresu, LG | 1 |
| Hodge, G | 1 |
| Hodge, S | 1 |
| Liu, H | 1 |
| Nguyen, P | 1 |
| Holmes-Liew, CL | 1 |
| Holmes, M | 1 |
| Xie, AX | 1 |
| Madayag, A | 1 |
| Minton, SK | 1 |
| McCarthy, KD | 1 |
| Malykhina, AP | 1 |
| Patel, BS | 1 |
| Kugel, MJ | 1 |
| Baehring, G | 1 |
| Ammit, AJ | 1 |
| Abusnina, A | 1 |
| Lugnier, C | 1 |
| Bin, Y | 1 |
| Xiao, Y | 1 |
| Huang, D | 1 |
| Ma, Z | 1 |
| Liang, Y | 1 |
| Bai, J | 1 |
| Zhang, W | 1 |
| Liang, Q | 1 |
| Zhang, J | 1 |
| Zhong, X | 1 |
| He, Z | 1 |
| Ruchel, JB | 1 |
| Bernardes, VM | 1 |
| Braun, JBS | 1 |
| Manzoni, AG | 1 |
| Passos, DF | 1 |
| Castilhos, LG | 1 |
| Abdalla, FH | 1 |
| de Oliveira, JS | 1 |
| de Andrade, CM | 1 |
| Casali, EA | 1 |
| da Cruz, IBM | 1 |
| Leal, DBR | 1 |
| Caramori, G | 2 |
| Coppolino, I | 1 |
| Cannavò, MF | 1 |
| Nucera, F | 1 |
| Proietto, A | 1 |
| Mumby, S | 1 |
| Ruggeri, P | 1 |
| Adcock, IM | 4 |
| Kirkham, PA | 1 |
| Whiteman, M | 1 |
| Winyard, PG | 1 |
| Gordon, F | 1 |
| Ford, PA | 1 |
| Barnes, PJ | 5 |
| Chung, KF | 1 |
| Cosío, BG | 4 |
| Jahn, A | 1 |
| Iglesias, A | 2 |
| Shafiek, H | 2 |
| Busquets, X | 1 |
| Agustí, A | 2 |
| Yanez, A | 1 |
| Córdova, R | 1 |
| Palou, A | 1 |
| Rodriguez-Roisin, R | 1 |
| Peces-Barba, G | 1 |
| Pascual, S | 1 |
| Gea, J | 1 |
| Sibila, O | 1 |
| Urbanova, A | 1 |
| Kertys, M | 1 |
| Simekova, M | 1 |
| Mikolka, P | 1 |
| Kosutova, P | 1 |
| Mokra, D | 1 |
| Mokry, J | 1 |
| Gallelli, L | 1 |
| Falcone, D | 1 |
| Cannataro, R | 1 |
| Perri, M | 1 |
| Serra, R | 1 |
| Pelaia, G | 1 |
| Maselli, R | 1 |
| Savino, R | 1 |
| Spaziano, G | 1 |
| D'Agostino, B | 1 |
| Bayram, H | 1 |
| Soriano, JB | 1 |
| Haskó, G | 1 |
| Cronstein, B | 1 |
| Zhang, WH | 1 |
| Cui, YY | 1 |
| Rong, WF | 1 |
| Cambier, C | 1 |
| Devillier, P | 2 |
| Bureau, F | 1 |
| Advenier, C | 1 |
| Gustin, P | 1 |
| Sun, X | 1 |
| Li, Q | 1 |
| Gong, Y | 1 |
| Ren, L | 1 |
| Wan, H | 1 |
| Deng, W | 1 |
| Singh, LP | 1 |
| Devi, TS | 1 |
| Nantwi, KD | 1 |
| Tsaprouni, L | 1 |
| Ito, K | 2 |
| Jazrawi, E | 1 |
| Ramos-Zepeda, G | 1 |
| Schröder, W | 1 |
| Rosenow, S | 1 |
| Herrero, JF | 1 |
| Ding, YL | 1 |
| Yao, WZ | 1 |
| Liu, Z | 1 |
| Wang, YZ | 1 |
| Saud, B | 1 |
| Nandi, J | 1 |
| Ong, G | 1 |
| Finocchiaro, S | 1 |
| Levine, RA | 1 |
| Watz, H | 1 |
| Bitter-Suermann, S | 1 |
| Kanniess, F | 1 |
| Magnussen, H | 1 |
| Singh, A | 1 |
| Middleton, E | 1 |
| Marone, G | 1 |
| Petracca, R | 1 |
| Condorelli, M | 1 |
| Santing, RE | 1 |
| Olymulder, CG | 1 |
| Van der Molen, K | 1 |
| Meurs, H | 1 |
| Zaagsma, J | 1 |
| Murphy, S | 1 |
| Kelly, HW | 1 |
| Barakat, M | 1 |
| du Souich, P | 2 |
| Boisseau, MR | 1 |
| Pruvost, A | 1 |
| Renard, M | 1 |
| Closse, C | 1 |
| Belloc, F | 1 |
| Seigneur, M | 1 |
| Maurel, A | 1 |
| Chorostowska-Wynimko, J | 1 |
| Escofier, N | 1 |
| Boichot, E | 1 |
| Germain, N | 1 |
| Silva, PM | 1 |
| Martins, MA | 1 |
| Lagente, V | 1 |
| Horiguchi, T | 1 |
| Tachikawa, S | 1 |
| Kasahara, J | 1 |
| Doi, M | 1 |
| Shiga, M | 1 |
| Miyazaki, J | 1 |
| Sasaki, Y | 1 |
| Hirose, M | 1 |
| Imazu, M | 1 |
| Heuer, HO | 1 |
| Leon, I | 1 |
| Anderson, GP | 1 |
| Jennewein, HM | 1 |
| Ohta, K | 1 |
| Yamashita, N | 1 |
| Kurdi, J | 1 |
| Maurice, H | 1 |
| El-Kadi, AO | 2 |
| Ong, H | 1 |
| Dalkara, S | 1 |
| Bélanger, PM | 1 |
| Souich, P | 1 |
| Barakat, MM | 1 |
| Ichiyama, T | 1 |
| Hasegawa, S | 1 |
| Matsubara, T | 1 |
| Hayashi, T | 1 |
| Furukawa, S | 1 |
| Nevzorova, VA | 1 |
| Suvorenko, TN | 1 |
| Konovalova, EN | 1 |
| Adanin, S | 1 |
| Yalovetskiy, IV | 1 |
| Nardulli, BA | 1 |
| Sam, AD | 1 |
| Jonjev, ZS | 1 |
| Law, WR | 1 |
| Terao, I | 1 |
| Sullivan, TJ | 2 |
| Parker, CW | 2 |
| Bonta, IL | 2 |
| Parnham, MJ | 2 |
| Adolfs, MJ | 1 |
| Atkinson, JP | 1 |
| Kelly, JP | 1 |
| Deporter, DA | 1 |
| Dieppe, PA | 1 |
| Glatt, M | 1 |
| Willoughby, DA | 1 |
| Erjefält, I | 2 |
| Persson, CG | 2 |
| König, P | 1 |
| Gustafsson, B | 1 |
| Luts, A | 1 |
| Sundler, F | 1 |
| Rosengren, S | 1 |
| Arfors, KE | 1 |
| Proctor, KG | 1 |
| Milgrom, H | 1 |
| Norris, AA | 1 |
| Leeson, ME | 1 |
| Jackson, DM | 1 |
| Holroyde, MC | 1 |
| Barrett, KE | 1 |
| Cohn, JA | 1 |
| Huott, PA | 1 |
| Wasserman, SI | 1 |
| Dharmsathaphorn, K | 1 |
| Reed, CE | 1 |
| Pauwels, R | 1 |
| Proud, D | 1 |
| Kagey-Sobotka, A | 1 |
| Naclerio, RM | 1 |
| Lichtenstein, LM | 1 |
| Bernstein, IL | 1 |
| Tomita, K | 1 |
| Ichikawa, A | 1 |
| Hayashi, H | 1 |
| Foret, JE | 1 |
| Weissmann, G | 1 |
| Zurier, RB | 1 |
| Hoffstein, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enhancement of In-vitro GC Function in Patients With COPD. A Randomised, Double Blind, Placebo Controlled, Parallel-group Study to Investigate the Effect of Theophylline and Fluticasone on Induced Sputum Cells Obtained Form COPD Patients[NCT00241631] | Phase 2 | 49 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| Multicenter 52 Weeks Double Blind Placebo-controlled Trial for the Assessment of Theophylline on Top of Combination Therapy in Severe COPD[NCT01599871] | Phase 3 | 70 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Molecular Mechanisms of COPD Exacerbations. Effect of Low-Dose Theophylline[NCT00671151] | 35 participants (Actual) | Interventional | 2005-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Interleukin 8 (IL8) assessed from sputum (NCT00241631)
Timeframe: 10 weeks
| Intervention | ng/mL (Mean) |
|---|---|
| Placebo | 33.3 |
| Steroid | 28.3 |
Supernatant collect, cell pellets count on slides (NCT00241631)
Timeframe: 10 weeks
| Intervention | millions cells/ ml (Mean) |
|---|---|
| Placebo | 5.42 |
| Steroid | 3.89 |
Total eosinophils cells assessed from sputum (NCT00241631)
Timeframe: 10 weeks
| Intervention | millions cells/ml (Mean) |
|---|---|
| Placebo | 0.132 |
| Steroid | 0.053 |
18 reviews available for theophylline and Innate Inflammatory Response
| Article | Year |
|---|---|
Therapeutic potentials of natural compounds acting on cyclic nucleotide phosphodiesterase families.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Asthma; Biological Products; Cell Line, Tumor; Cell Pr | 2017 |
Transcription inhibitors and inflammatory cell activity.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Humans; Inflammation; Pulmonary Di | 2019 |
[The pathogenesis of chronic obstructive pulmonary disease, steroid resistance and the place of theophylline in the treatment].
Topics: Bronchodilator Agents; Drug Resistance; Histone Deacetylases; Humans; Inflammation; Pulmonary Diseas | 2009 |
Methylxanthines and inflammatory cells.
Topics: Animals; Caffeine; Humans; Immune System; Inflammation; Methotrexate; Receptors, Purinergic P1; Theo | 2011 |
Can β2-adrenoceptor agonists, anticholinergic drugs, and theophylline contribute to the control of pulmonary inflammation and emphysema in COPD?
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Bronchodilator Agents; Cholinergic Antagonists; Diseas | 2012 |
Theophylline: new perspectives for an old drug.
Topics: Apoptosis; Asthma; Bronchodilator Agents; Gene Expression; Histone Deacetylases; Humans; Inflammatio | 2003 |
[Physiopathology of COPD: choosing the right therapeutic targets].
Topics: Adrenal Cortex Hormones; Aged; Albuterol; Animals; Bacterial Infections; Bronchodilator Agents; Carb | 2003 |
Histone acetylation and deacetylation: importance in inflammatory lung diseases.
Topics: Acetylation; Acetyltransferases; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Chromatin A | 2005 |
[Pharmacological treatment of COPD and future of anti-inflammatory therapy].
Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti- | 2006 |
Airway smooth muscle, asthma, and calcium ions.
Topics: Asthma; Asthma, Exercise-Induced; Autacoids; Binding Sites; Calcium; Calcium Channel Blockers; Calmo | 1984 |
Asthma, inflammation, and airway hyperresponsiveness in children.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Allergens; Anti-Inflammatory Agents; Asthma; Bron | 1993 |
[Immunomodulatory properties of subtherapeutic levels of theophylline].
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Antigens, CD; Asthma; CD4-CD8 Ratio; Forc | 1997 |
Apoptosis of eosinophils and lymphocytes in allergic inflammation.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Apoptosis; Bronchodilator Agents; Eosinophils; Hu | 1999 |
[Apoptosis and inflammation in bronchial asthma].
Topics: Anti-Inflammatory Agents; Apoptosis; Asthma; Bronchodilator Agents; Eosinophils; fas Receptor; Gluco | 2001 |
Pharmacologic modulation of inflammatory mediator release by rat mast cells.
Topics: Animals; Antibodies; Calcimycin; Calcium; Catecholamines; Cell Membrane; Concanavalin A; Cyclic AMP; | 1976 |
A step-wise approach to the changing drug therapy of asthma.
Topics: Adrenal Insufficiency; Adult; Anti-Inflammatory Agents; Asthma; Child; Cromolyn Sodium; Humans; Infl | 1992 |
Asthma--something old, something new ....
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Eosinophils; Humans; Inflammation; Interl | 1991 |
The effects of theophylline on airway inflammation.
Topics: Adult; Animals; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Provocation Tests; Bronchitis; | 1987 |
7 trials available for theophylline and Innate Inflammatory Response
| Article | Year |
|---|---|
Evaluating the therapeutic effect and toxicity of theophylline in infertile men with asthenoteratozoospermia: a double-blind, randomized clinical trial study.
Topics: Adenosine Monophosphate; Antioxidants; Asthenozoospermia; DNA Fragmentation; Eosine Yellowish-(YS); | 2022 |
Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD.
Topics: Adrenal Cortex Hormones; Biomarkers; Bronchodilator Agents; Disease Progression; Forced Expiratory V | 2014 |
Oral Low-dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients With Severe COPD: A Pilot Clinical Trial.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Aged; Anti | 2016 |
[Changes of leukotriene B4 in induced sputum and plasma of patients with chronic obstructive pulmonary disease and the effects of theophylline].
Topics: Aged; Bronchodilator Agents; Case-Control Studies; Female; Humans; Inflammation; Leukotriene B4; Mal | 2005 |
Suppression of airway inflammation by theophylline in adult bronchial asthma.
Topics: Administration, Oral; Adult; Asthma; Biomarkers; Blood Proteins; Bronchitis; Bronchodilator Agents; | 1999 |
[Effects of once-daily low-dose administration of sustained-release theophylline on airway inflammation and airway hyperresponsiveness in patients with asthma].
Topics: Administration, Oral; Adult; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchodilator Agent | 2002 |
The effects of theophylline on airway inflammation.
Topics: Adult; Animals; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Provocation Tests; Bronchitis; | 1987 |
43 other studies available for theophylline and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Effect of doxofylline on pulmonary inflammatory response and oxidative stress during mechanical ventilation in rats with COPD.
Topics: Animals; Disease Models, Animal; Inflammation; Interleukin-10; Male; Oxidative Stress; Pulmonary Dis | 2022 |
Comparison of anti-inflammatory mechanisms between doxofylline and theophylline in human monocytes.
Topics: Anti-Inflammatory Agents; Humans; Inflammation; Lipopolysaccharides; Monocytes; Protein Kinase C; Te | 2019 |
BOS Is Associated With Decreased SIRT1 in Peripheral Blood Proinflammatory T, NK, and NKT-like Lymphocytes.
Topics: Adult; Age Factors; Bronchiolitis Obliterans; Carbazoles; Case-Control Studies; Curcumin; Cytokines; | 2019 |
Sensory satellite glial Gq-GPCR activation alleviates inflammatory pain via peripheral adenosine 1 receptor activation.
Topics: Animals; Benzilates; Clozapine; Freund's Adjuvant; Genes, Synthetic; GTP-Binding Protein alpha Subun | 2020 |
Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect.
Topics: Anti-Inflammatory Agents; Bronchi; Bronchodilator Agents; Cells, Cultured; Cyclic AMP; Cyclohexaneca | 2017 |
Theophylline inhibits cigarette smoke-induced inflammation in skeletal muscle by upregulating HDAC2 expression and decreasing NF-κB activation.
Topics: Animals; Cell Line; Gene Expression Regulation, Enzymologic; Histone Deacetylase 2; Inflammation; Ma | 2019 |
Lipotoxicity-associated inflammation is prevented by guarana (
Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Caffeine; Disease Models, Anim | 2021 |
Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD.
Topics: Adult; Aged; Blotting, Western; Bronchodilator Agents; Case-Control Studies; Cell Line; Cytokines; D | 2015 |
Bronchodilator and Anti-Inflammatory Action of Theophylline in a Model of Ovalbumin-Induced Allergic Inflammation.
Topics: Airway Resistance; Animals; Anti-Inflammatory Agents; Bronchial Hyperreactivity; Bronchoconstriction | 2016 |
Theophylline action on primary human bronchial epithelial cells under proinflammatory stimuli and steroidal drugs: a therapeutic rationale approach.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Bronchi; Cells, Cultured; Dose-Response Relations | 2017 |
Theophylline again? Reasons for believing.
Topics: Anti-Inflammatory Agents; Aspirin; Asthma; Bronchodilator Agents; Humans; Inflammation; Phosphoric D | 2009 |
Low-dose theophylline restores corticosteroid responsiveness in rats with smoke-induced airway inflammation.
Topics: Adrenal Cortex Hormones; Animals; Bronchoalveolar Lavage Fluid; Budesonide; Dose-Response Relationsh | 2012 |
Theophylline regulates inflammatory and neurotrophic factor signals in functional recovery after C2-hemisection in adult rats.
Topics: Actins; Animals; Blotting, Western; Bronchodilator Agents; Carrier Proteins; Cell Cycle Proteins; El | 2012 |
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.
Topics: Aged; Blotting, Western; Bronchodilator Agents; Enzyme-Linked Immunosorbent Assay; Female; Glutathio | 2004 |
Spinal vs. supraspinal antinociceptive activity of the adenosine A(1) receptor agonist cyclopentyl-adenosine in rats with inflammation.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Analgesics; Animals; B | 2004 |
Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Down-Regulation; Ileitis; | 2005 |
Beyond the "ABC approach".
Topics: Acute Disease; Bacterial Infections; Biomarkers; C-Reactive Protein; Humans; Hypoxia; Inflammation; | 2007 |
Adenosine receptors on human inflammatory cells.
Topics: Adenosine; Alprostadil; Cyclic AMP; Humans; Inflammation; Kinetics; Lymphocytes; Prostaglandins E; R | 1984 |
Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Analysis of Variance; Animals; Asth | 1995 |
Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction.
Topics: Animals; Area Under Curve; Bronchodilator Agents; Calcium Channel Blockers; Cytochrome P-450 Enzyme | 1996 |
Effect of buflomedil on the neutrophil-endothelial cell interaction under inflammatory and hypoxia conditions.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-2 Receptor Antagonists; Adrenergic al | 1996 |
Effects of interleukin-10 and modulators of cyclic AMP formation on endotoxin-induced inflammation in rat lung.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Animals; Bronchoalveolar Lavage Flu | 1999 |
Comparative effects of a glucocorticosteroid, theophylline and the peptido-leukotriene-antagonist CGP 45715A on antigen-induced early and late phase airway response and inflammatory cell influx in sensitised guinea pigs.
Topics: Animals; Benzopyrans; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agen | 1999 |
Effect of hypoxia alone or combined with inflammation and 3-methylcholanthrene on hepatic cytochrome P450 in conscious rabbits.
Topics: Animals; Apoproteins; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cyto | 1999 |
L-NAME prevents in vivo the inactivation but not the down-regulation of hepatic cytochrome P450 caused by an acute inflammatory reaction.
Topics: Animals; Cytochrome P-450 Enzyme System; Down-Regulation; Enzyme Inhibitors; Hepatocytes; Inflammati | 2001 |
Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bronchodilator Agents; DNA-Binding Proteins; Dose-Response | 2001 |
Inhibiting adenosine deaminase modulates the systemic inflammatory response syndrome in endotoxemia and sepsis.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Bacterial Infections; Blood; Chronic D | 2002 |
Mimickry of anti-granuloma effect of prostaglandin E by dibutyryl cyclic-AMP and some phosphodiesterase inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents; Bucladesine; Disease Models, Animal; | 1979 |
Stimulation by alcohols of cyclic AMP metabolism in human leukocytes. Possible role of cyclic AMP in the anti-inflammatory effects of ethanol.
Topics: Adenylyl Cyclases; Alcohols; Blood Platelets; Cell Membrane; Cyclic AMP; Epinephrine; Ethanol; Granu | 1977 |
The relation of cyclic AMP levels to phagocytosis and enzyme release in acute inflammation in vivo.
Topics: Acid Phosphatase; Animals; Bucladesine; Cyclic AMP; Exudates and Transudates; Glucuronidase; Inflamm | 1977 |
Time-dependent stimulatory and inhibitory effects of prostaglandin E1 on exudative and tissue components of granulomatous inflammation in rats.
Topics: Animals; Exudates and Transudates; Fatty Acids, Essential; Inflammation; Leukocyte Count; Male; Pros | 1979 |
Increased sensitivity to toluene diisocyanate (TDI) in airways previously exposed to low doses of TDI.
Topics: Administration, Cutaneous; Administration, Topical; Animals; Budesonide; Guinea Pigs; Inflammation; | 1992 |
Toluene diisocyanate produces an increase in airway tone that outlasts the inflammatory exudation phase.
Topics: Airway Resistance; Animals; Carbachol; Exudates and Transudates; Guinea Pigs; Inflammation; Male; Mu | 1991 |
Potentiation of leukotriene B4-mediated inflammatory response by the adenosine antagonist, 8-phenyl theophylline.
Topics: Animals; Capillary Permeability; Cell Count; Cheek; Cricetinae; Dose-Response Relationship, Drug; Do | 1991 |
Modulation of neurogenic inflammation in rat trachea.
Topics: Albuterol; Animals; Cromolyn Sodium; Dexamethasone; Electric Stimulation; Inflammation; Male; Methys | 1990 |
Immune-related intestinal chloride secretion. II. Effect of adenosine on T84 cell line.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Calcium; Cell Line; Chlorides; Cycl | 1990 |
New therapeutic approaches in asthma.
Topics: Adrenergic beta-Agonists; Aerosols; Airway Obstruction; Aspirin; Asthma; Bronchi; Bronchodilator Age | 1986 |
Pharmacology of upper airways challenge.
Topics: Aspirin; Cyproheptadine; Exocytosis; Humans; Hypersensitivity; Inflammation; Mast Cells; Nasal Mucos | 1987 |
Cromolyn sodium in the treatment of asthma: coming of age in the United States.
Topics: Aerosols; Asthma; Biological Availability; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Cr | 1985 |
Effects of cyclic 3',5'-adenosine monophosphate on inflammations induced by inorganic pyrophosphate, ATP and other phlogistins.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Cyclic AMP; Diphosphates; Histamine Relea | 1972 |
Stimulation and retardation of limb regeneration by adenosine 3',5'-monophosphate and related compounds.
Topics: Acetylcholine; Animals; Cell Differentiation; Cyclic AMP; Denervation; Epithelium; Forelimb; Hyperpl | 1973 |
Leukocytes as secretory organs of inflammation.
Topics: Atropine; Blood Platelets; Bucladesine; Carbachol; Cell Survival; Cells, Cultured; Colchicine; Cycli | 1973 |