theophylline has been researched along with Hypercapnia in 28 studies
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of adenosine in rat coronary flow regulation during acidosis was evaluated in isolated, perfused, Langendorff rat heart preparations exposed to brief periods of hypercapnic or metabolic acidosis." | 7.70 | The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis. ( O'Regan, MH; Phillis, JW; Song, D, 1998) |
| "Arousal is an important protective mechanism that aids in the resolution of obstructive sleep apnea in adults and children, but its role in neonatal apnea has not been investigated." | 7.68 | Behavioral arousal in newborn infants and its association with termination of apnea. ( Belan, MA; Cowen, CP; Mathew, OP; Thoppil, CK, 1991) |
| "Theophylline was found to increase hemoglobin saturation and decrease carbon dioxide pressures without significant effects on the overall efficiency of pulmonary gas exchange." | 5.28 | [Effects of theophylline on the course of hypercapnic respiratory insufficiency]. ( Bevignani, G; Chiappini, F; Fresu, R, 1990) |
| "The purine nucleoside, adenosine, has been implicated as a neuromodulator in central respiratory depression during prolonged exposure to hypoxia." | 5.08 | The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine. ( Christie, JM; Griffiths, TL; Holgate, ST; Parsons, ST, 1997) |
| " Although more controlled studies would be helpful, relatively clear-cut indications for the use of ventilatory stimulants exist for hypercapnic obesity-hypoventilation patients (medroxyprogesterone), myxedema (thyroid replacement), central apnea (acetazolamide), and periodic breathing in congestive heart failure (theophylline)." | 4.80 | Pharmacologic treatment of sleep-disordered breathing. ( Hudgel, DW; Thanakitcharu, S, 1998) |
| "Hypercapnia (20% CO2) depressed the reflex potentials, which were partially reversed by an adenosine A1 receptor antagonist, 8-cyclopentyl theophylline, but not by a P2 receptor antagonist, pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid." | 3.75 | Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro. ( Ban, M; Ito, S; Ohta, T; Otsuguro, K, 2009) |
| "Our findings indicate that obese rats possess altered adenosinergic modulation of ventilatory responses to acute and sustained hypoxia in two opposite ways." | 3.73 | Adenosinergic modulation of ventilation in obese zucker rats. ( Farkas, GA; Lee, SD; Nakano, H, 2005) |
| "5% O2), to topical adenosine (10[-5] and 10[-4] mol/L) and to arterial hypercapnia (inhalation of 5% and 10% CO2 in air) before and after 10 minutes of global ischemia." | 3.70 | Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. ( Bari, F; Busija, DW; Louis, TM, 1998) |
| "The role of adenosine in rat coronary flow regulation during acidosis was evaluated in isolated, perfused, Langendorff rat heart preparations exposed to brief periods of hypercapnic or metabolic acidosis." | 3.70 | The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis. ( O'Regan, MH; Phillis, JW; Song, D, 1998) |
| "Arousal is an important protective mechanism that aids in the resolution of obstructive sleep apnea in adults and children, but its role in neonatal apnea has not been investigated." | 3.68 | Behavioral arousal in newborn infants and its association with termination of apnea. ( Belan, MA; Cowen, CP; Mathew, OP; Thoppil, CK, 1991) |
| "Fifty-four episodes of hypercapnic status asthmaticus (Pa CO2 50 mmHg or more) were treated with intravenous theophylline (6 mg/kg over 30 minutes, then 1 mg/kg/hour), intravenous hydrocortisone hemisuccinate (1 g then 500 mg 4-hourly) rehydration and oxygen therapy at a sufficient rate to obtain a Pa O2 of 80 mmHg or more." | 3.67 | [Hypercapnic status asthmaticus. Rapid reversibility of hypercapnia under medical treatment]. ( Boissinot, E; Ginies, G; Perrotin, D, 1986) |
| " The increased beta-adrenergic activity thus generated was associated with marked reductions in the pulmonary vasoconstrictor responses to hypoxia, hypercapnic acidosis, and histamine, but not to serotonin." | 3.65 | beta-Receptor influence on lung vasoconstrictor responses to hypoxia and humoral agents. ( Bergofsky, EH; Naftchi, NE; Porcelli, RJ; Viau, AT, 1977) |
| "Medications partially improve obstructive sleep apnea and stabilize periodic breathing at altitude." | 2.50 | Medication effects on sleep and breathing. ( Lee-Chiong, T; Seda, G; Tsai, S, 2014) |
| "The goal of management of patients with respiratory failure is to restore them to a state of quiet breathing, without complication." | 2.41 | Management of respiratory failure in patients with asthma. ( Corbridge, T; Gluckman, TJ, 2000) |
| "Chronic obstructive lung disease affects over 15 million people in the United States." | 2.39 | Management of chronic obstructive pulmonary disease. ( Donohue, JF, 1995) |
| "Levels increased during anoxia, during hypercapnia, and to an even greater extent during anoxic hypercapnia." | 1.30 | A role for adenosine in metabolic depression in the marine invertebrate Sipunculus nudus. ( Nilsson, GE; Pörtner, HO; Reipschläger, A, 1997) |
| "Theophylline (0." | 1.28 | The effect of theophylline on hypoxic, hypercapnic hamster diaphragm muscle in vitro. ( Esau, SA, 1991) |
| "Theophylline was found to increase hemoglobin saturation and decrease carbon dioxide pressures without significant effects on the overall efficiency of pulmonary gas exchange." | 1.28 | [Effects of theophylline on the course of hypercapnic respiratory insufficiency]. ( Bevignani, G; Chiappini, F; Fresu, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (35.71) | 18.7374 |
| 1990's | 12 (42.86) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seda, G | 1 |
| Tsai, S | 1 |
| Lee-Chiong, T | 1 |
| Otsuguro, K | 1 |
| Ban, M | 1 |
| Ohta, T | 1 |
| Ito, S | 1 |
| Goineau, S | 1 |
| Rompion, S | 1 |
| Guillaume, P | 1 |
| Picard, S | 1 |
| Liu, C | 1 |
| Cao, Y | 1 |
| Malhotra, A | 1 |
| Ling, L | 1 |
| Donohue, JF | 1 |
| Lee, SD | 1 |
| Nakano, H | 1 |
| Farkas, GA | 1 |
| Nikki, P | 1 |
| Meretoja, O | 1 |
| Valtonen, V | 1 |
| Mäkeläinen, A | 1 |
| Saikku, P | 1 |
| Mattila, S | 1 |
| Taskinen, E | 1 |
| Letarte, L | 1 |
| du Souich, P | 1 |
| Sanders, JS | 1 |
| Berman, TM | 1 |
| Bartlett, MM | 1 |
| Kronenberg, RS | 1 |
| Reid, JM | 1 |
| Davies, AG | 1 |
| Ashcroft, FM | 1 |
| Paterson, DJ | 1 |
| Griffiths, TL | 1 |
| Christie, JM | 1 |
| Parsons, ST | 1 |
| Holgate, ST | 1 |
| Reipschläger, A | 1 |
| Nilsson, GE | 1 |
| Pörtner, HO | 1 |
| Bari, F | 1 |
| Louis, TM | 1 |
| Busija, DW | 1 |
| Habgood, MD | 1 |
| Knott, GW | 1 |
| Dziegielewska, KM | 1 |
| Saunders, NR | 1 |
| Hudgel, DW | 1 |
| Thanakitcharu, S | 1 |
| Phillis, JW | 1 |
| Song, D | 1 |
| O'Regan, MH | 1 |
| Gluckman, TJ | 1 |
| Corbridge, T | 1 |
| Ferrara, A | 1 |
| Numeroso, R | 1 |
| Santerni, N | 1 |
| Fumagalli, G | 1 |
| Porcelli, RJ | 1 |
| Viau, AT | 1 |
| Naftchi, NE | 1 |
| Bergofsky, EH | 1 |
| Swaminathan, S | 1 |
| Paton, JY | 1 |
| Ward, SL | 1 |
| Sargent, CW | 1 |
| Keens, TG | 1 |
| Thoppil, CK | 1 |
| Belan, MA | 1 |
| Cowen, CP | 1 |
| Mathew, OP | 1 |
| Esau, SA | 1 |
| Chiappini, F | 1 |
| Bevignani, G | 1 |
| Fresu, R | 1 |
| Perrotin, D | 1 |
| Boissinot, E | 1 |
| Ginies, G | 1 |
| Goldring, RM | 1 |
| Turino, GM | 1 |
| Heinemann, HO | 1 |
| Barer, GR | 1 |
| Howard, P | 1 |
| McCurrie, JR | 1 |
| Shaw, JW | 1 |
| Kaiser, D | 1 |
| Nadjafian, C | 1 |
| Werner, E | 1 |
| Mentzel, H | 1 |
4 reviews available for theophylline and Hypercapnia
| Article | Year |
|---|---|
Medication effects on sleep and breathing.
Topics: Acetazolamide; Altitude; Androgens; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Be | 2014 |
Management of chronic obstructive pulmonary disease.
Topics: Adrenergic beta-Agonists; alpha 1-Antitrypsin Deficiency; Bronchitis; Bronchodilator Agents; Choline | 1995 |
Pharmacologic treatment of sleep-disordered breathing.
Topics: Acetazolamide; Antihypertensive Agents; Apnea; Bronchodilator Agents; Diuretics; Dyspnea; Evidence-B | 1998 |
Management of respiratory failure in patients with asthma.
Topics: Administration, Inhalation; Albuterol; Asthma; Bronchodilator Agents; Calcium Channel Blockers; Gluc | 2000 |
2 trials available for theophylline and Hypercapnia
| Article | Year |
|---|---|
The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine.
Topics: Adenosine; Administration, Oral; Adult; Analysis of Variance; Bronchodilator Agents; Carbon Dioxide; | 1997 |
Theophylline does not increase ventilatory responses to hypercapnia or hypoxia.
Topics: Adult; Double-Blind Method; Female; Humans; Hypercapnia; Hypoxia; Male; Pulmonary Gas Exchange; Resp | 1992 |
22 other studies available for theophylline and Hypercapnia
| Article | Year |
|---|---|
Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Animals; Animals, Newborn; Ele | 2009 |
Ventilatory function assessment in safety pharmacology: optimization of rodent studies using normocapnic or hypercapnic conditions.
Topics: Animals; Guinea Pigs; Hypercapnia; Male; Mice; Mice, Inbred BALB C; Models, Animal; Morphine; Pharma | 2010 |
Sleep fragmentation attenuates the hypercapnic (but not hypoxic) ventilatory responses via adenosine A1 receptors in awake rats.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Blood Gas Analysis; Hypercapnia; L | 2011 |
Adenosinergic modulation of ventilation in obese zucker rats.
Topics: Adenosine; Aminophylline; Animals; Carbon Dioxide; Hypercapnia; Hypoxia; Male; Obesity; Oxygen; Oxyg | 2005 |
Severe bronchiolitis probably caused by varicella-zoster virus.
Topics: Adult; Biopsy; Bronchi; Bronchiolitis, Viral; Chickenpox; Herpesvirus 3, Human; Humans; Hypercapnia; | 1982 |
Influence of hypercapnia and/or hypoxemia and metabolic acidosis on theophylline kinetics in the conscious rabbit.
Topics: Acidosis, Respiratory; Animals; Hypercapnia; Hypoxia; Kinetics; Male; Metabolic Clearance Rate; Rabb | 1984 |
Increased hypoxic ventilatory drive due to administration of aminophylline in normal men.
Topics: Administration, Oral; Adult; Aminophylline; Carbon Dioxide; Humans; Hypercapnia; Hypoxia; Infusions, | 1980 |
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.
Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hyperc | 1995 |
A role for adenosine in metabolic depression in the marine invertebrate Sipunculus nudus.
Topics: Adenosine; Animals; Hypercapnia; Hypoxia; Nematoda; Nerve Tissue; Neurotransmitter Agents; Oxygen Co | 1997 |
Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets.
Topics: Adenosine; Adenosine Triphosphate; Administration, Topical; Analysis of Variance; Animals; Arteriole | 1998 |
Permeability of the developing and mature blood-brain barriers to theophylline in rats.
Topics: Acidosis, Respiratory; Age Factors; Animals; Animals, Newborn; Blood-Brain Barrier; Capillary Permea | 1998 |
The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis.
Topics: Acidosis; Acidosis, Respiratory; Adenosine; Animals; Caffeine; Coronary Circulation; Hypercapnia; Ma | 1998 |
[Changes in acid-base equilibrium of the arterial blood in hypoxemic-eucapnic subjects subjected to oxygen therapy with and without an antiphosphodiesterase drug].
Topics: Acid-Base Equilibrium; Arteries; Blood; Carbon Dioxide; Chlorides; Chronic Disease; Electrolytes; Hu | 1976 |
beta-Receptor influence on lung vasoconstrictor responses to hypoxia and humoral agents.
Topics: Acidosis; Animals; Cats; Cyclic AMP; Epinephrine; Histamine; Hypercapnia; Hypoxia; Pulmonary Circula | 1977 |
Behavioral arousal in newborn infants and its association with termination of apnea.
Topics: Airway Obstruction; Apnea; Arousal; Humans; Hypercapnia; Hypoxia; Infant, Newborn; Infant, Premature | 1991 |
The effect of theophylline on hypoxic, hypercapnic hamster diaphragm muscle in vitro.
Topics: Acidosis, Respiratory; Animals; Cell Hypoxia; Cricetinae; Diaphragm; Hypercapnia; Membrane Potential | 1991 |
[Effects of theophylline on the course of hypercapnic respiratory insufficiency].
Topics: Aged; Drug Evaluation; Humans; Hypercapnia; Lung Diseases, Obstructive; Male; Middle Aged; Respirato | 1990 |
[Hypercapnic status asthmaticus. Rapid reversibility of hypercapnia under medical treatment].
Topics: Adolescent; Adult; Aged; Asthma; Emergencies; Female; Humans; Hydrocortisone; Hypercapnia; Male; Mid | 1986 |
Respiratory-renal adjustments in chronic hypercapnia in man. Extracellular bicarbonate concentration and the regulation of ventilation.
Topics: Adult; Ammonia; Ammonium Chloride; Bicarbonates; Body Weight; Carbon Dioxide; Chlorides; Chronic Dis | 1971 |
Changes in the pulmonary circulation after bronchial occlusion in anesthetized dogs and cats.
Topics: Air; Animals; Bicarbonates; Blood Flow Velocity; Blood Pressure; Bretylium Compounds; Cats; Dogs; Hy | 1969 |
[Effect of Perphyllon A on gas exchange, energy balance and peripheral oxygen supply of the newborn].
Topics: Acidosis; Humans; Hypercapnia; Infant, Newborn; Infant, Newborn, Diseases; Lactates; Oxygen Consumpt | 1969 |
[Asphyxia neonatorum. II. Treatment with vasodilator and vagolytic agents].
Topics: Acidosis, Respiratory; Asphyxia Neonatorum; Atropine; Blood Circulation; Humans; Hypercapnia; Hypoxi | 1966 |