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theophylline and Hypercapnia

theophylline has been researched along with Hypercapnia in 28 studies

Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.

Research Excerpts

ExcerptRelevanceReference
"The role of adenosine in rat coronary flow regulation during acidosis was evaluated in isolated, perfused, Langendorff rat heart preparations exposed to brief periods of hypercapnic or metabolic acidosis."7.70The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis. ( O'Regan, MH; Phillis, JW; Song, D, 1998)
"Arousal is an important protective mechanism that aids in the resolution of obstructive sleep apnea in adults and children, but its role in neonatal apnea has not been investigated."7.68Behavioral arousal in newborn infants and its association with termination of apnea. ( Belan, MA; Cowen, CP; Mathew, OP; Thoppil, CK, 1991)
"Theophylline was found to increase hemoglobin saturation and decrease carbon dioxide pressures without significant effects on the overall efficiency of pulmonary gas exchange."5.28[Effects of theophylline on the course of hypercapnic respiratory insufficiency]. ( Bevignani, G; Chiappini, F; Fresu, R, 1990)
"The purine nucleoside, adenosine, has been implicated as a neuromodulator in central respiratory depression during prolonged exposure to hypoxia."5.08The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine. ( Christie, JM; Griffiths, TL; Holgate, ST; Parsons, ST, 1997)
" Although more controlled studies would be helpful, relatively clear-cut indications for the use of ventilatory stimulants exist for hypercapnic obesity-hypoventilation patients (medroxyprogesterone), myxedema (thyroid replacement), central apnea (acetazolamide), and periodic breathing in congestive heart failure (theophylline)."4.80Pharmacologic treatment of sleep-disordered breathing. ( Hudgel, DW; Thanakitcharu, S, 1998)
"Hypercapnia (20% CO2) depressed the reflex potentials, which were partially reversed by an adenosine A1 receptor antagonist, 8-cyclopentyl theophylline, but not by a P2 receptor antagonist, pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid."3.75Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro. ( Ban, M; Ito, S; Ohta, T; Otsuguro, K, 2009)
"Our findings indicate that obese rats possess altered adenosinergic modulation of ventilatory responses to acute and sustained hypoxia in two opposite ways."3.73Adenosinergic modulation of ventilation in obese zucker rats. ( Farkas, GA; Lee, SD; Nakano, H, 2005)
"5% O2), to topical adenosine (10[-5] and 10[-4] mol/L) and to arterial hypercapnia (inhalation of 5% and 10% CO2 in air) before and after 10 minutes of global ischemia."3.70Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. ( Bari, F; Busija, DW; Louis, TM, 1998)
"The role of adenosine in rat coronary flow regulation during acidosis was evaluated in isolated, perfused, Langendorff rat heart preparations exposed to brief periods of hypercapnic or metabolic acidosis."3.70The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis. ( O'Regan, MH; Phillis, JW; Song, D, 1998)
"Arousal is an important protective mechanism that aids in the resolution of obstructive sleep apnea in adults and children, but its role in neonatal apnea has not been investigated."3.68Behavioral arousal in newborn infants and its association with termination of apnea. ( Belan, MA; Cowen, CP; Mathew, OP; Thoppil, CK, 1991)
"Fifty-four episodes of hypercapnic status asthmaticus (Pa CO2 50 mmHg or more) were treated with intravenous theophylline (6 mg/kg over 30 minutes, then 1 mg/kg/hour), intravenous hydrocortisone hemisuccinate (1 g then 500 mg 4-hourly) rehydration and oxygen therapy at a sufficient rate to obtain a Pa O2 of 80 mmHg or more."3.67[Hypercapnic status asthmaticus. Rapid reversibility of hypercapnia under medical treatment]. ( Boissinot, E; Ginies, G; Perrotin, D, 1986)
" The increased beta-adrenergic activity thus generated was associated with marked reductions in the pulmonary vasoconstrictor responses to hypoxia, hypercapnic acidosis, and histamine, but not to serotonin."3.65beta-Receptor influence on lung vasoconstrictor responses to hypoxia and humoral agents. ( Bergofsky, EH; Naftchi, NE; Porcelli, RJ; Viau, AT, 1977)
"Medications partially improve obstructive sleep apnea and stabilize periodic breathing at altitude."2.50Medication effects on sleep and breathing. ( Lee-Chiong, T; Seda, G; Tsai, S, 2014)
"The goal of management of patients with respiratory failure is to restore them to a state of quiet breathing, without complication."2.41Management of respiratory failure in patients with asthma. ( Corbridge, T; Gluckman, TJ, 2000)
"Chronic obstructive lung disease affects over 15 million people in the United States."2.39Management of chronic obstructive pulmonary disease. ( Donohue, JF, 1995)
"Levels increased during anoxia, during hypercapnia, and to an even greater extent during anoxic hypercapnia."1.30A role for adenosine in metabolic depression in the marine invertebrate Sipunculus nudus. ( Nilsson, GE; Pörtner, HO; Reipschläger, A, 1997)
"Theophylline (0."1.28The effect of theophylline on hypoxic, hypercapnic hamster diaphragm muscle in vitro. ( Esau, SA, 1991)
"Theophylline was found to increase hemoglobin saturation and decrease carbon dioxide pressures without significant effects on the overall efficiency of pulmonary gas exchange."1.28[Effects of theophylline on the course of hypercapnic respiratory insufficiency]. ( Bevignani, G; Chiappini, F; Fresu, R, 1990)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199010 (35.71)18.7374
1990's12 (42.86)18.2507
2000's3 (10.71)29.6817
2010's3 (10.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Seda, G1
Tsai, S1
Lee-Chiong, T1
Otsuguro, K1
Ban, M1
Ohta, T1
Ito, S1
Goineau, S1
Rompion, S1
Guillaume, P1
Picard, S1
Liu, C1
Cao, Y1
Malhotra, A1
Ling, L1
Donohue, JF1
Lee, SD1
Nakano, H1
Farkas, GA1
Nikki, P1
Meretoja, O1
Valtonen, V1
Mäkeläinen, A1
Saikku, P1
Mattila, S1
Taskinen, E1
Letarte, L1
du Souich, P1
Sanders, JS1
Berman, TM1
Bartlett, MM1
Kronenberg, RS1
Reid, JM1
Davies, AG1
Ashcroft, FM1
Paterson, DJ1
Griffiths, TL1
Christie, JM1
Parsons, ST1
Holgate, ST1
Reipschläger, A1
Nilsson, GE1
Pörtner, HO1
Bari, F1
Louis, TM1
Busija, DW1
Habgood, MD1
Knott, GW1
Dziegielewska, KM1
Saunders, NR1
Hudgel, DW1
Thanakitcharu, S1
Phillis, JW1
Song, D1
O'Regan, MH1
Gluckman, TJ1
Corbridge, T1
Ferrara, A1
Numeroso, R1
Santerni, N1
Fumagalli, G1
Porcelli, RJ1
Viau, AT1
Naftchi, NE1
Bergofsky, EH1
Swaminathan, S1
Paton, JY1
Ward, SL1
Sargent, CW1
Keens, TG1
Thoppil, CK1
Belan, MA1
Cowen, CP1
Mathew, OP1
Esau, SA1
Chiappini, F1
Bevignani, G1
Fresu, R1
Perrotin, D1
Boissinot, E1
Ginies, G1
Goldring, RM1
Turino, GM1
Heinemann, HO1
Barer, GR1
Howard, P1
McCurrie, JR1
Shaw, JW1
Kaiser, D1
Nadjafian, C1
Werner, E1
Mentzel, H1

Reviews

4 reviews available for theophylline and Hypercapnia

ArticleYear
Medication effects on sleep and breathing.
    Clinics in chest medicine, 2014, Volume: 35, Issue:3

    Topics: Acetazolamide; Altitude; Androgens; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Be

2014
Management of chronic obstructive pulmonary disease.
    Current opinion in pulmonary medicine, 1995, Volume: 1, Issue:2

    Topics: Adrenergic beta-Agonists; alpha 1-Antitrypsin Deficiency; Bronchitis; Bronchodilator Agents; Choline

1995
Pharmacologic treatment of sleep-disordered breathing.
    American journal of respiratory and critical care medicine, 1998, Volume: 158, Issue:3

    Topics: Acetazolamide; Antihypertensive Agents; Apnea; Bronchodilator Agents; Diuretics; Dyspnea; Evidence-B

1998
Management of respiratory failure in patients with asthma.
    Current opinion in pulmonary medicine, 2000, Volume: 6, Issue:1

    Topics: Administration, Inhalation; Albuterol; Asthma; Bronchodilator Agents; Calcium Channel Blockers; Gluc

2000

Trials

2 trials available for theophylline and Hypercapnia

ArticleYear
The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine.
    The European respiratory journal, 1997, Volume: 10, Issue:1

    Topics: Adenosine; Administration, Oral; Adult; Analysis of Variance; Bronchodilator Agents; Carbon Dioxide;

1997
Theophylline does not increase ventilatory responses to hypercapnia or hypoxia.
    The American review of respiratory disease, 1992, Volume: 146, Issue:6

    Topics: Adult; Double-Blind Method; Female; Humans; Hypercapnia; Hypoxia; Male; Pulmonary Gas Exchange; Resp

1992

Other Studies

22 other studies available for theophylline and Hypercapnia

ArticleYear
Roles of purines in synaptic modulation evoked by hypercapnia in isolated spinal cord of neonatal rat in vitro.
    British journal of pharmacology, 2009, Volume: 156, Issue:7

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Triphosphate; Animals; Animals, Newborn; Ele

2009
Ventilatory function assessment in safety pharmacology: optimization of rodent studies using normocapnic or hypercapnic conditions.
    Toxicology and applied pharmacology, 2010, Sep-15, Volume: 247, Issue:3

    Topics: Animals; Guinea Pigs; Hypercapnia; Male; Mice; Mice, Inbred BALB C; Models, Animal; Morphine; Pharma

2010
Sleep fragmentation attenuates the hypercapnic (but not hypoxic) ventilatory responses via adenosine A1 receptors in awake rats.
    Respiratory physiology & neurobiology, 2011, Jan-31, Volume: 175, Issue:1

    Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Blood Gas Analysis; Hypercapnia; L

2011
Adenosinergic modulation of ventilation in obese zucker rats.
    Obesity research, 2005, Volume: 13, Issue:3

    Topics: Adenosine; Aminophylline; Animals; Carbon Dioxide; Hypercapnia; Hypoxia; Male; Obesity; Oxygen; Oxyg

2005
Severe bronchiolitis probably caused by varicella-zoster virus.
    Critical care medicine, 1982, Volume: 10, Issue:5

    Topics: Adult; Biopsy; Bronchi; Bronchiolitis, Viral; Chickenpox; Herpesvirus 3, Human; Humans; Hypercapnia;

1982
Influence of hypercapnia and/or hypoxemia and metabolic acidosis on theophylline kinetics in the conscious rabbit.
    The American review of respiratory disease, 1984, Volume: 129, Issue:5

    Topics: Acidosis, Respiratory; Animals; Hypercapnia; Hypoxia; Kinetics; Male; Metabolic Clearance Rate; Rabb

1984
Increased hypoxic ventilatory drive due to administration of aminophylline in normal men.
    Chest, 1980, Volume: 78, Issue:2

    Topics: Administration, Oral; Adult; Aminophylline; Carbon Dioxide; Humans; Hypercapnia; Hypoxia; Infusions,

1980
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia.
    The American journal of physiology, 1995, Volume: 269, Issue:3 Pt 2

    Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hyperc

1995
A role for adenosine in metabolic depression in the marine invertebrate Sipunculus nudus.
    The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 2

    Topics: Adenosine; Animals; Hypercapnia; Hypoxia; Nematoda; Nerve Tissue; Neurotransmitter Agents; Oxygen Co

1997
Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets.
    Stroke, 1998, Volume: 29, Issue:1

    Topics: Adenosine; Adenosine Triphosphate; Administration, Topical; Analysis of Variance; Animals; Arteriole

1998
Permeability of the developing and mature blood-brain barriers to theophylline in rats.
    Clinical and experimental pharmacology & physiology, 1998, Volume: 25, Issue:5

    Topics: Acidosis, Respiratory; Age Factors; Animals; Animals, Newborn; Blood-Brain Barrier; Capillary Permea

1998
The role of adenosine in rat coronary flow regulation during respiratory and metabolic acidosis.
    European journal of pharmacology, 1998, Sep-04, Volume: 356, Issue:2-3

    Topics: Acidosis; Acidosis, Respiratory; Adenosine; Animals; Caffeine; Coronary Circulation; Hypercapnia; Ma

1998
[Changes in acid-base equilibrium of the arterial blood in hypoxemic-eucapnic subjects subjected to oxygen therapy with and without an antiphosphodiesterase drug].
    Minerva medica, 1976, Sep-22, Volume: 67, Issue:44

    Topics: Acid-Base Equilibrium; Arteries; Blood; Carbon Dioxide; Chlorides; Chronic Disease; Electrolytes; Hu

1976
beta-Receptor influence on lung vasoconstrictor responses to hypoxia and humoral agents.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1977, Volume: 43, Issue:4

    Topics: Acidosis; Animals; Cats; Cyclic AMP; Epinephrine; Histamine; Hypercapnia; Hypoxia; Pulmonary Circula

1977
Behavioral arousal in newborn infants and its association with termination of apnea.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 70, Issue:6

    Topics: Airway Obstruction; Apnea; Arousal; Humans; Hypercapnia; Hypoxia; Infant, Newborn; Infant, Premature

1991
The effect of theophylline on hypoxic, hypercapnic hamster diaphragm muscle in vitro.
    The American review of respiratory disease, 1991, Volume: 143, Issue:5 Pt 1

    Topics: Acidosis, Respiratory; Animals; Cell Hypoxia; Cricetinae; Diaphragm; Hypercapnia; Membrane Potential

1991
[Effects of theophylline on the course of hypercapnic respiratory insufficiency].
    La Clinica terapeutica, 1990, Oct-31, Volume: 135, Issue:2

    Topics: Aged; Drug Evaluation; Humans; Hypercapnia; Lung Diseases, Obstructive; Male; Middle Aged; Respirato

1990
[Hypercapnic status asthmaticus. Rapid reversibility of hypercapnia under medical treatment].
    Presse medicale (Paris, France : 1983), 1986, Oct-18, Volume: 15, Issue:36

    Topics: Adolescent; Adult; Aged; Asthma; Emergencies; Female; Humans; Hydrocortisone; Hypercapnia; Male; Mid

1986
Respiratory-renal adjustments in chronic hypercapnia in man. Extracellular bicarbonate concentration and the regulation of ventilation.
    The American journal of medicine, 1971, Volume: 51, Issue:6

    Topics: Adult; Ammonia; Ammonium Chloride; Bicarbonates; Body Weight; Carbon Dioxide; Chlorides; Chronic Dis

1971
Changes in the pulmonary circulation after bronchial occlusion in anesthetized dogs and cats.
    Circulation research, 1969, Volume: 25, Issue:6

    Topics: Air; Animals; Bicarbonates; Blood Flow Velocity; Blood Pressure; Bretylium Compounds; Cats; Dogs; Hy

1969
[Effect of Perphyllon A on gas exchange, energy balance and peripheral oxygen supply of the newborn].
    Monatsschrift fur Kinderheilkunde, 1969, Volume: 117, Issue:4

    Topics: Acidosis; Humans; Hypercapnia; Infant, Newborn; Infant, Newborn, Diseases; Lactates; Oxygen Consumpt

1969
[Asphyxia neonatorum. II. Treatment with vasodilator and vagolytic agents].
    Zeitschrift fur Kinderheilkunde, 1966, Volume: 96, Issue:2

    Topics: Acidosis, Respiratory; Asphyxia Neonatorum; Atropine; Blood Circulation; Humans; Hypercapnia; Hypoxi

1966