Page last updated: 2024-10-22

theophylline and Heart Defects, Congenital

theophylline has been researched along with Heart Defects, Congenital in 11 studies

Heart Defects, Congenital: Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.

Research Excerpts

ExcerptRelevanceReference
" To help understand optimal aminophylline (salt formulation of theophylline) dosing strategies in this population, a population-based pharmacokinetic model was developed using nonlinear mixed-effects modeling (NONMEM) from 71 children (median age 5 months; 90% range 1 week to 10 years) who underwent cardiac surgery requiring CPB and received aminophylline as part of a previous randomized controlled trial."2.82Theophylline Population Pharmacokinetics and Dosing in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass. ( Axelrod, DM; Frymoyer, A; Grimm, PC; Su, F; Sutherland, SM, 2016)
"Theophylline has been shown to be a potent cardiovascular teratogen in animals, but there has been no evidence linking theophylline with congenital anomalies in infants."1.28Cardiovascular anomalies associated with prenatal exposure to theophylline. ( Myers, TL; Park, JM; Schmer, V, 1990)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19909 (81.82)18.7374
1990's1 (9.09)18.2507
2000's0 (0.00)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Frymoyer, A1
Su, F1
Grimm, PC1
Sutherland, SM1
Axelrod, DM1
LANG, EF1
Morgan, WJ1
Taussig, LM1
Gilbert, EF2
Bruyere, HJ2
Ishikawa, S1
Cheung, MO1
Hodach, RJ1
Park, JM1
Schmer, V1
Myers, TL1
Lin, CI1
Tao, PL1
Chang, YF1
Chiang, BN1
Gnezditskaia, EV1
Bukhova, VP1
Zakharova, NA1
Matsuoka, R1
Fang, TT1
Nishikawa, T1
Opitz, JM1
Richards, W1
Weigand, KH1
Menner, K2
Rautenburg, HW2

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00005279]0 participants Observational1971-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for theophylline and Heart Defects, Congenital

ArticleYear
The chronic bronchitis complex in children.
    Pediatric clinics of North America, 1984, Volume: 31, Issue:4

    Topics: Adrenergic beta-Agonists; Adult; Age Factors; Air Pollution; Anti-Bacterial Agents; Asthma; Bronchit

1984
Differential diagnosis of childhood asthma.
    Current problems in pediatrics, 1974, Volume: 4, Issue:5

    Topics: Age Factors; Asthma; Child; Child Health Services; Child, Institutionalized; Cystic Fibrosis; Defici

1974

Trials

1 trial available for theophylline and Heart Defects, Congenital

ArticleYear
Theophylline Population Pharmacokinetics and Dosing in Children Following Congenital Heart Surgery With Cardiopulmonary Bypass.
    Journal of clinical pharmacology, 2016, Volume: 56, Issue:9

    Topics: Adolescent; Aminophylline; Cardiopulmonary Bypass; Cardiotonic Agents; Child; Child, Preschool; Dose

2016

Other Studies

8 other studies available for theophylline and Heart Defects, Congenital

ArticleYear
[ON THE DIAGNOSIS OF LEFT-RIGHT SHUNT WITH THE DYE DILUTION TECHNIC].
    Arztliche Forschung, 1965, Feb-10, Volume: 19

    Topics: Adolescent; Child; Diagnosis; Dye Dilution Technique; Heart Defects, Congenital; Hemodynamics; Human

1965
The effects of methylxanthines on catecholamine-stimulated and normal chick embryos.
    Teratology, 1977, Volume: 16, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Abnormalities, Drug-Induced; Animals; Aortic Aneurysm; Aortic A

1977
Cardiovascular anomalies associated with prenatal exposure to theophylline.
    Southern medical journal, 1990, Volume: 83, Issue:12

    Topics: Adult; Asthma; Drug Administration Schedule; Female; Heart Defects, Congenital; Humans; Infant, Newb

1990
Pacemaker activity is modulated by tissue levels of cyclic adenosine 3',5'-monophosphate in human atrial fibers.
    International journal of cardiology, 1989, Volume: 25, Issue:1

    Topics: Action Potentials; Adult; Atrial Function; Child, Preschool; Cyclic AMP; Cyclic GMP; Epinephrine; Fe

1989
[Receptors for the secretory component on human thymic lymphocytes. Stimulation of their expression as affected by adenosine, theophylline and a thymic lymphocyte supernatant].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 104, Issue:7

    Topics: Adenosine; Adolescent; Cell Extracts; Child; Child, Preschool; Colostrum; Female; Fluorescent Antibo

1987
Experimentally induced cardiovascular malformations in the chick embryo. Part II. Teratogenic effect of Tedral (theophylline, ephedrine, and phenobarbital) on cardiac development in chick embryos.
    Birth defects original article series, 1987, Volume: 23, Issue:1

    Topics: Animals; Cardiovascular System; Chick Embryo; Dose-Response Relationship, Drug; Drug Combinations; D

1987
[Pharmacodynamics of cardiac output in childhood].
    Deutsche medizinische Wochenschrift (1946), 1971, Aug-06, Volume: 96, Issue:32

    Topics: Adolescent; Amyl Nitrite; Aortic Valve Stenosis; Bronchodilator Agents; Cardiac Output; Child; Child

1971
[Studies on the hemodynamic effect of Complamine].
    Medizinische Klinik, 1967, Jun-30, Volume: 62, Issue:26

    Topics: Adolescent; Blood Circulation; Blood Pressure; Cardiac Catheterization; Child; Child, Preschool; Fem

1967