theophylline and Disease Models, Animal studies

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

Excerpt	Relevance	Reference
"Theophylline inhibits capsaicin-induced cough under both normal and "disease" conditions by decreasing the excitability of sensory nerves through activation of small- and intermediate-conductance calcium-activated potassium channels."	7.80	Theophylline inhibits the cough reflex through a novel mechanism of action. ( Adcock, JJ; Belvisi, MG; Birrell, MA; Dubuis, E; Grace, MS; Maher, SA; Wortley, MA, 2014)
" The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction."	7.77	Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. ( Aoyama, T; Bai, Y; Iwasa, M; Minatoguchi, S; Murakami, H; Nishigaki, K; Sumi, S; Takemura, G; Uno, B; Ushikoshi, H; Yamada, Y, 2011)
"Theophylline-associated seizures (TAS) often progress to prolonged or treatment-resistant convulsions."	7.76	Adenosine A1 receptor blockage mediates theophylline-associated seizures. ( Fukuda, M; Hino, H; Ishii, E; Kuzume, K; Morimoto, T; Suzuki, Y, 2010)
" The current experiment has tested the hypothesis that green tea and the methylxanthine theophylline contained in tea inhibit the progression of neuroendocrine lung carcinogenesis in hamsters with hyperoxic lung injury and initiated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) while promoting the development of Clara cell-derived pulmonary adenocarcinomas initiated by NNK in healthy hamsters."	7.72	Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. ( Porter, B; Riechert, A; Schmoyer, R; Schuller, HM; Walker, K, 2004)
"The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats."	7.71	Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. ( Chaudhary, G; Gupta, YK; Srivastava, AK, 2002)
" Recent studies have shown beneficial effects of an adenosine A(2A) receptor agonist in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress and consumption of coffee can precipitate dystonic attacks."	7.71	Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. ( Hamann, M; Richter, A, 2001)
"These data suggest that adenosine receptor-mediated actions during sepsis affect vascular beds selectively and indicate a significant role for adenosine in resting perfusion redistribution in sepsis."	7.70	Adenosine receptor antagonism affects regional resting vascular resistance during rat peritoneal sepsis. ( Alden, KJ; Ferguson, JL; Law, WR; Motew, SJ; Mourelatos, MG; Sam, AD; Sharma, AC, 1998)
"Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat."	7.69	Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995)
"Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats."	7.69	Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. ( George, B; Kulkarni, SK, 1997)
"The effect of theophylline on cerebral blood flow (CBF), oxygen transport, and energy metabolism was investigated during and following brief episodes of asphyxia."	7.69	Cerebral blood flow and metabolism during repeated asphyxias in newborn piglets: influence of theophylline. ( Delivoria-Papadopoulos, M; Goplerud, JM, 1994)
"Seizures, often with fatal outcome, are a manifestation of pronounced theophylline toxicity."	7.68	Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat. ( Gilhar, D; Hoffman, A; Pinto, E, 1993)
"Theophylline, the bronchodilating agent, can cause life-threatening, generalized seizures when plasma concentrations exceed the usual therapeutic concentration range."	7.67	Kinetics of drug action in disease states. XVIII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Ramzan, IM, 1987)
"To assess fever-induced changes in theophylline pharmacokinetics in the rabbit model, six healthy, male, New Zealand white rabbits were studied using a randomized, matched-pair design."	7.67	Influence of endotoxin-induced fever on the pharmacokinetics of theophylline in the rabbit model. ( Johnson, JA; Prince, RA; Weinberger, MM, 1989)
"rats with a pentylenetetrazole-induced seizure score of 3 or more on a seizure scale ranging from 0 to 6) and death rate compared with those obtained for rats pre-treated with an equivalent intraperitoneal dose (140 mg kg-1) of acepifylline ('equivalent dose' referred to here denotes the theophylline content of the two preparations)."	5.30	A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1997)
"Theophylline has been used for over a century in the treatment of asthma and while it is used principally as a bronchodilator, a number of recent studies have demonstrated potential anti-inflammatory and immunomodulatory activity."	4.80	The role of theophylline and phosphodiesterase4 isoenzyme inhibitors as anti-inflammatory drugs. ( Landells, LJ; Page, CP; Spina, D, 1998)
" Additionally, incarvillateine attenuated mechanical allodynia induced by spared nerve injury or paclitaxel, whereas normal mechanical sensation was not affected."	3.81	Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system. ( Gong, ZH; Huang, B; Jia, YX; Su, RB; Wang, ML; Wang, ZT; Yi, SP; Yu, G; Zhang, FY, 2015)
"Theophylline inhibits capsaicin-induced cough under both normal and "disease" conditions by decreasing the excitability of sensory nerves through activation of small- and intermediate-conductance calcium-activated potassium channels."	3.80	Theophylline inhibits the cough reflex through a novel mechanism of action. ( Adcock, JJ; Belvisi, MG; Birrell, MA; Dubuis, E; Grace, MS; Maher, SA; Wortley, MA, 2014)
"Theophylline derivatives have long been recognized as potent bronchodilators for the relief of acute asthma."	3.78	Design and synthesis of new 8-anilide theophylline derivatives as bronchodilators and antibacterial agents. ( Alim, AA; Hayallah, AK; Talhouni, AA, 2012)
"Methylxanthines especially theophylline have been recognized as potent bronchodilators for the relief of acute asthma for over 65 years."	3.77	Design and synthesis of some new theophylline derivatives with bronchodilator and antibacterial activities. ( Alim, AA; Elgaher, WA; Hayallah, AM; Salem, OI, 2011)
" The present study examined whether or not cilostazol reduces the myocardial infarct size, and investigated its mechanism in a rabbit model of myocardial infarction."	3.77	Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. ( Aoyama, T; Bai, Y; Iwasa, M; Minatoguchi, S; Murakami, H; Nishigaki, K; Sumi, S; Takemura, G; Uno, B; Ushikoshi, H; Yamada, Y, 2011)
"We evaluated the wake-promoting efficacy of paraxanthine, caffeine, and a reference wake-promoting compound, modafinil, in a mice model of narcolepsy, a prototypical disease model of hypersomnia."	3.76	Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice. ( Fujiki, N; Ishimaru, Y; Kotorii, N; Nishino, S; Okuro, M; Sokoloff, P, 2010)
"Theophylline-associated seizures (TAS) often progress to prolonged or treatment-resistant convulsions."	3.76	Adenosine A1 receptor blockage mediates theophylline-associated seizures. ( Fukuda, M; Hino, H; Ishii, E; Kuzume, K; Morimoto, T; Suzuki, Y, 2010)
"Adenosine has potent anticonvulsant effects on various models of experimental epilepsy."	3.74	Anticonvulsant effects of focal and intracerebroventricular adenosine on penicillin-induced epileptiform activity in rats. ( Marangoz, C; Yildirim, M, 2007)
"Previous studies indicate that adenosine supplementation or nitric oxide synthase (NOS) inhibition during reperfusion exert protective effects against myocardial ischemia-reperfusion (I/R) injury."	3.74	Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury. ( Bouhaddi, M; Davani, S; Kantelip, JP; Reyssie, H; Rochette, L; Royer, B; Vergely, C, 2007)
" The current experiment has tested the hypothesis that green tea and the methylxanthine theophylline contained in tea inhibit the progression of neuroendocrine lung carcinogenesis in hamsters with hyperoxic lung injury and initiated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) while promoting the development of Clara cell-derived pulmonary adenocarcinomas initiated by NNK in healthy hamsters."	3.72	Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. ( Porter, B; Riechert, A; Schmoyer, R; Schuller, HM; Walker, K, 2004)
"The effect of trans-resveratrol (resveratrol), a polyphenolic compound with potent antioxidant activity, was investigated against pentylenetetrazole (PTZ) induced seizures in rats."	3.71	Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. ( Chaudhary, G; Gupta, YK; Srivastava, AK, 2002)
" Recent studies have shown beneficial effects of an adenosine A(2A) receptor agonist in dt(sz) mutant hamsters, an animal model of paroxysmal dystonia, in which stress and consumption of coffee can precipitate dystonic attacks."	3.71	Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. ( Hamann, M; Richter, A, 2001)
"Landiolol controlled tachyarrhythmias associated with theophylline toxicity."	3.70	Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs. ( Fujii, Y; Hoshi, T; Inomata, S; Miyabe, M; Takahashi, S; Toyooka, H, 2000)
"These data suggest that adenosine receptor-mediated actions during sepsis affect vascular beds selectively and indicate a significant role for adenosine in resting perfusion redistribution in sepsis."	3.70	Adenosine receptor antagonism affects regional resting vascular resistance during rat peritoneal sepsis. ( Alden, KJ; Ferguson, JL; Law, WR; Motew, SJ; Mourelatos, MG; Sam, AD; Sharma, AC, 1998)
"The effect of theophylline on cerebral blood flow (CBF), oxygen transport, and energy metabolism was investigated during and following brief episodes of asphyxia."	3.69	Cerebral blood flow and metabolism during repeated asphyxias in newborn piglets: influence of theophylline. ( Delivoria-Papadopoulos, M; Goplerud, JM, 1994)
"A new guinea pig model of allergic asthma was used to investigate the effects of low doses of the phosphodiesterase inhibitors, rolipram (phosphodiesterase IV selective), ORG 20241 (N-hydroxy-4-(3,4-dimethoxyphenyl)-thiazole-2-carboximidamide; dual phosphodiesterase III/IV inhibitor with some selectivity for the phosphodiesterase IV isoenzyme), and of theophylline (non-selective) on allergen-induced early and late phase asthmatic reactions, bronchial hyperreactivity to histamine inhalation, and airway inflammation."	3.69	Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs. ( Meurs, H; Olymulder, CG; Santing, RE; Van der Molen, K; Zaagsma, J, 1995)
"Theophylline-induced seizures have significant morbidity and mortality and are difficult to treat."	3.69	Pyridoxine as therapy in theophylline-induced seizures. ( Glenn, GM; Kelly, P; Krober, MS; McCarty, J; Weir, M, 1995)
"Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats."	3.69	Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. ( George, B; Kulkarni, SK, 1997)
" Studies were conducted under control conditions and in the presence of four inhibitors of potential mediators of the reactive hyperemia response: the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (30 microM), the adenosine antagonist 8-(p-sulfophenyl)theophylline (50 microM), the K+ cyclic adenosine triphosphate-dependent channel antagonist glibenclamide (10 microM), and the cyclooxygenase inhibitor indomethacin (10 microM)."	3.69	Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. ( Dumont, L; Fontaine, E; Jasmin, G; Véronneau, M; Viau, S, 1997)
"The aims were to examine the role of adenosine receptors in the mechanism of preconditioning in a chronic rabbit model of myocardial infarction; to assess whether the preconditioning effect is blocked by an adenosine receptor antagonist, 8-phenyltheophylline; and to determine whether an adenosine A1 receptor agonist, R(-)N6-2-phenylisopropyl adenosine (R-PIA), mimics infarct size limitation by preconditioning."	3.68	Role of adenosine receptor activation in myocardial infarct size limitation by ischaemic preconditioning. ( Iimura, O; Miki, T; Miura, T; Shimamoto, K; Tsuchida, A, 1992)
" Allergic bronchial eosinophilia in guinea pigs was inhibited by orally administered dexamethasone and methylprednisolone."	3.68	Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs. ( Chand, N; De Vine, CL; Diamantis, W; Harrison, JE; Jakubicki, RG; Nolan, KW; Pillar, J; Rooney, SM; Sofia, RD, 1993)
"Seizures, often with fatal outcome, are a manifestation of pronounced theophylline toxicity."	3.68	Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat. ( Gilhar, D; Hoffman, A; Pinto, E, 1993)
"To assess fever-induced changes in theophylline pharmacokinetics in the rabbit model, six healthy, male, New Zealand white rabbits were studied using a randomized, matched-pair design."	3.67	Influence of endotoxin-induced fever on the pharmacokinetics of theophylline in the rabbit model. ( Johnson, JA; Prince, RA; Weinberger, MM, 1989)
"Theophylline, the bronchodilating agent, can cause life-threatening, generalized seizures when plasma concentrations exceed the usual therapeutic concentration range."	3.67	Kinetics of drug action in disease states. XVIII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats. ( Levy, G; Ramzan, IM, 1987)
"Verapamil was found to be an effective inhibitor of isometric tension in in vitro, experimental anaphylaxis in guinea pig trachealis smooth muscle."	3.66	Effect of calcium antagonists in experimental asthma. ( Barbero, L; Markowicz, J; Weiss, EB, 1982)
"The incidence of hereditary hyperlipidemia amounts to about 8% and rises when secondary causes of lipid metabolism disturbances are taken into consideration."	2.68	[Comparative pharmacokinetics of theophylline in hyperlipidemia in animals and humans]. ( Górnik, W, 1996)
"Obstructive sleep apnea is a prevalent disorder associated with significant neurobehavioral and cardiovascular morbidities."	2.41	Pharmacotherapies for obstructive sleep apnea: how close are we? ( Veasey, SC, 2001)
"Ventricular fibrillation is a major mechanism of sudden death."	2.36	Catecholamine-mediated arrhythmias in acute myocardial infarction. Experimental evidence and role of beta-adrenoceptor blockade. ( Lubbe, WF; Opie, LH, 1979)
"Allergic rhinitis was induced in five of the six groups with ovalbumin, and four of these five groups were treated with salbutamol, budesonide, theophylline, and montelukast."	1.91	Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis. ( Athari, SS; Ma, Y; Tu, Y; Yang, XH, 2023)
"Doxofylline was shown to improve ventilation and air exchange during mechanical ventilation in rats with COPD, reduce the inflammatory response and oxidative stress, and mitigate the degree of pulmonary tissue injury."	1.72	Effect of doxofylline on pulmonary inflammatory response and oxidative stress during mechanical ventilation in rats with COPD. ( Chen, ZY; Chu, SQ; Li, Y; Lin, YM; Wu, JH; Xie, WX; Zhang, XQ; Zhang, Y, 2022)
"Theophylline treatment also reduced MPO activity and tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1 β) and interleukin 6 (IL-6) concentrations in inflamed colon."	1.46	The effect of theophylline on acetic acid induced ulcerative colitis in rats. ( Ghasemi-Pirbaluti, M; Hosseini, MJ; Motaghi, E; Najafi, A, 2017)
"Due to the complex nature of Alzheimer's disease, multi-target-directed ligand approaches are one of the most promising strategies in the search for effective treatments."	1.42	Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. ( Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K, 2015)
"Animals subjected to cardiac arrest and cooled by CHA survived better and showed less neuronal cell death than normothermic control animals."	1.42	Translating drug-induced hibernation to therapeutic hypothermia. ( Combs, VM; Drew, KL; Jinka, TR, 2015)
"Doxofylline is a xanthine drug that has been used as a treatment for respiratory diseases for more than 30 years."	1.40	Doxofylline, a novofylline inhibits lung inflammation induced by lipopolysacharide in the mouse. ( Man, F; Page, CP; Riffo-Vasquez, Y, 2014)
"Adenosine concentration was significantly increased in IPC effluent (2."	1.40	Remote cardioprotection by transfer of coronary effluent from ischemic preconditioned rabbit heart preserves mitochondrial integrity and function via adenosine receptor activation. ( Caldarone, CA; Callahan, J; Fu, YY; Kato, H; Leung, CH; Nielsen, JM; Redington, AN; Tropak, MB; Wang, L, 2014)
"During drug development, seizure threshold tests are widely used to identify potential proconvulsant activity of investigational drugs."	1.38	Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models. ( Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W, 2012)
"The dose-response curve for Ach of RL was elevated that for and CL was depressed significantly in the ovalbumin-sensitised animals compared to normal control guinea pigs."	1.37	Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs. ( Iwasaki, S; Watanabe, A; Yamakage, M; Zhou, J, 2011)
"Theophylline was administered intravenously in cumulative doses up to 93."	1.37	Effects of theophylline on anesthetized malignant hyperthermia-susceptible pigs. ( Fiege, M; Gerbershagen, MU; Kolodzie, K; Wappler, F; Weisshorn, R, 2011)
" Using a bivascular liver perfusion dose-response curves to adenosine of the HA were performed in the presence and the absence of pan-adenosine blocker (8-SPT), A1 blocker (caffeine) or nitric oxide synthase-blocker (l-NMMA) after preconstriction with an alpha1-agonist (methoxamine)."	1.36	A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver. ( Groszmann, RJ; Mehal, WZ; Ripoll, C; Zipprich, A, 2010)
"Ischemia was induced by active hypoperfusion of the circumflex coronary artery territory."	1.33	How to distinguish between ischemic and nonischemic postsystolic thickening: a strain rate imaging study. ( Bijnens, B; Broscheit, JA; Claus, P; Ertl, G; Strotmann, JM; Sutherland, GR; Voelker, W; Weidemann, F, 2006)
"rats with a pentylenetetrazole-induced seizure score of 3 or more on a seizure scale ranging from 0 to 6) and death rate compared with those obtained for rats pre-treated with an equivalent intraperitoneal dose (140 mg kg-1) of acepifylline ('equivalent dose' referred to here denotes the theophylline content of the two preparations)."	1.30	A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. ( Chakrabarti, A; Garg, SK; Saini, HK, 1997)
"Adenosine has been identified as a factor in the protection afforded against regional tissue necrosis by such preconditioning."	1.29	Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart. ( Cave, AC; Collis, CS; Downey, JM; Hearse, DJ, 1993)
"To evaluate an animal model of multiple-dose activated charcoal (MDAC) therapy and correlate the pharmacokinetic properties of four drugs with the efficacy of MDAC."	1.29	Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy. ( Chyka, PA; Holley, JE; Mandrell, TD; Sugathan, P, 1995)
"This experiment was performed to evaluate the usefulness of an experimental fibrosis model by bile duct ligation as a pharmacokinetic model of a disease state."	1.29	Pharmacokinetics of theophylline: effects of hepatic fibrosis in rats induced bile duct ligation. ( Ham, SH; Han, SS; Kim, JB; Kim, KY; Sohn, DH, 1995)
"for 10 min)-induced hypotension, arrhythmias, and sudden death."	1.29	Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats. ( Alleva, FR; Balazs, T; Joseph, X; Vick, JA; Whitehurst, VE; Zhang, J, 1996)
" Toxic levels of theophylline were associated with hypokalemia, hypophosphatemia, hyperglycemia, metabolic acidosis, and hypotension in both the patient and the experimental series."	1.27	Theophylline toxicity and the beta-adrenergic system. ( Curtis, GP; Kearney, TE; Manoguerra, AS; Ziegler, MG, 1985)
"The pharmacokinetic response of theophylline following the oral administration of activated charcoal was investigated in rabbits."	1.27	Kinetics of theophylline clearance in gastrointestinal dialysis with charcoal. ( Huang, JD, 1987)

Research

Studies (142)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Calculated Estimated Glomerular Filtration Rate (eGFR)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (19.01)	18.7374
1990's	39 (27.46)	18.2507
2000's	32 (22.54)	29.6817
2010's	39 (27.46)	24.3611
2020's	5 (3.52)	2.80

Authors	Studies
Colotta, V	1
Catarzi, D	1
Varano, F	1
Lenzi, O	1
Filacchioni, G	1
Martini, C	1
Trincavelli, L	1
Ciampi, O	1
Traini, C	1
Pugliese, AM	1
Pedata, F	1
Morizzo, E	1
Moro, S	1
Więckowska, A	1
Więckowski, K	1
Bajda, M	1
Brus, B	1
Sałat, K	1
Czerwińska, P	1
Gobec, S	1
Filipek, B	1
Malawska, B	1
Solinski, HJ	1
Dranchak, P	1
Oliphant, E	1
Gu, X	1
Earnest, TW	1
Braisted, J	1
Inglese, J	1
Hoon, MA	1
Abrams, RPM	1
Yasgar, A	1
Teramoto, T	1
Lee, MH	1
Dorjsuren, D	1
Eastman, RT	1
Malik, N	1
Zakharov, AV	1
Li, W	1
Bachani, M	1
Brimacombe, K	1
Steiner, JP	1
Hall, MD	1
Balasubramanian, A	1
Jadhav, A	1
Padmanabhan, R	1
Simeonov, A	1
Nath, A	1
Chen, ZY	1
Lin, YM	1
Wu, JH	1
Zhang, XQ	1
Zhang, Y	3
Xie, WX	1
Chu, SQ	1
Li, Y	2
Ma, Y	1
Yang, XH	1
Tu, Y	1
Athari, SS	1
Zheng, XF	1
Chen, DD	1
Zhu, XL	1
Le Grange, JM	1
Zhou, LQ	1
Zhang, JN	1
Ghasemi-Pirbaluti, M	1
Motaghi, E	1
Najafi, A	1
Hosseini, MJ	1
Riffo-Vasquez, Y	2
Venkatasamy, R	1
Page, CP	3
Gaafar, AGA	1
Messiha, BAS	1
Abdelkafy, AML	1
Ruchel, JB	1
Bernardes, VM	1
Braun, JBS	1
Manzoni, AG	1
Passos, DF	1
Castilhos, LG	1
Abdalla, FH	1
de Oliveira, JS	1
de Andrade, CM	1
Casali, EA	1
da Cruz, IBM	1
Leal, DBR	1
Leung, CH	1
Wang, L	4
Nielsen, JM	1
Tropak, MB	1
Fu, YY	1
Kato, H	1
Callahan, J	1
Redington, AN	1
Caldarone, CA	1
Dubuis, E	1
Wortley, MA	1
Grace, MS	1
Maher, SA	1
Adcock, JJ	1
Birrell, MA	1
Belvisi, MG	1
Man, F	1
Tohda, Y	1
He, H	1
Chen, F	1
Ni, W	1
Li, J	2
Partyka, A	1
Jarosz, J	1
Wasik, A	1
Jastrzębska-Więsek, M	1
Zagórska, A	1
Pawłowski, M	1
Wesołowska, A	1
Zygmunt, M	1
Chłoń-Rzepa, G	1
Sapa, J	1
Jinka, TR	1
Combs, VM	1
Drew, KL	1
Ozturk, SA	1
Ceylan, C	1
Serel, TA	1
Doluoglu, OG	1
Soyupek, AS	1
Guzel, A	1
Özorak, A	1
Uz, E	1
Savas, HB	1
Baspinar, S	1
Hoy, KC	1
Alilain, WJ	1
Wang, ML	1
Yu, G	1
Yi, SP	1
Zhang, FY	1
Wang, ZT	1
Huang, B	1
Su, RB	1
Jia, YX	1
Gong, ZH	1
Lakatos, RK	1
Dobolyi, Á	1
Todorov, MI	1
Kékesi, KA	1
Juhász, G	1
Aleksza, M	1
Kovács, Z	1
Oñatibia-Astibia, A	1
Franco, R	1
Martínez-Pinilla, E	1
Hasegawa, M	1
Hada, J	1
Abe, T	1
Honda, K	1
Shimizu, A	1
Urade, M	1
Cao, C	3
Cirrito, JR	1
Lin, X	2
Verges, DK	1
Dickson, A	1
Mamcarz, M	2
Zhang, C	3
Mori, T	1
Arendash, GW	1
Holtzman, DM	1
Potter, H	1
Trevitt, J	1
Kawa, K	1
Jalali, A	1
Larsen, C	1
Nantwi, KD	4
Eldaif, SM	1
Deneve, JA	1
Wang, NP	1
Jiang, R	1
Mosunjac, M	1
Mutrie, CJ	1
Guyton, RA	1
Zhao, ZQ	1
Vinten-Johansen, J	1
Gudziol, V	1
Pietsch, J	1
Witt, M	1
Hummel, T	1
Fukuda, M	1
Suzuki, Y	1
Hino, H	1
Kuzume, K	1
Morimoto, T	1
Ishii, E	1
Mathur, N	1
Sood, S	1
Wang, S	1
van Oort, RJ	1
Sarma, S	1
Li, N	1
Skapura, DG	1
Bayle, JH	1
Valderrábano, M	1
Wehrens, XH	1
Mizutani, N	2
Fuchikami, J	1
Takahashi, M	1
Nabe, T	2
Yoshino, S	2
Kohno, S	1
Zipprich, A	1
Mehal, WZ	1
Ripoll, C	1
Groszmann, RJ	1
Okuro, M	1
Fujiki, N	1
Kotorii, N	1
Ishimaru, Y	1
Sokoloff, P	1
Nishino, S	1
Constantinescu, AO	1
Ilie, A	1
Ciocan, D	1
Zagrean, AM	1
Zagrean, L	1
Moldovan, M	1
Oransay, K	1
Kalkan, S	1
Hocaoglu, N	1
Arici, A	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Efficacy Of Doxophylline As A Sparing Treatment For Inhaled Corticosteroids In Mexican Children With Asthma[NCT03879590]	Phase 3	60 participants (Anticipated)	Interventional	2019-05-31	Not yet recruiting
Aminophylline for Patients With Post-Dural Puncture Headache: a Prospective, Multi-center, Randomized Controlled Trial[NCT02522013]	Phase 3	126 participants (Actual)	Interventional	2015-10-31	Completed
Perioperative Aminophylline to Improve High Risk Renal Graft Outcome- a Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT01759862]		50 participants (Actual)	Interventional	2012-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The investigators will measure blood creatinine on post-operative day 5 and using the Schwartz equation will calculate estimated glomerular filtration rate (GFR) to determine kidney function. (NCT01759862)
Timeframe: 5 days

Presence of Fibrosis Measured on Protocol Biopsy

Intervention	ml/min/1.73m2 (Mean)
Aminophylline	67.39
Control	80.48

The investigators will use the same cores that are obtained during routine 6 months protocol biopsies to quantify the amount of fibrosis (NCT01759862)
Timeframe: 6 months

Urinary NGAL (Neutrophil Gelatinase-associated Lipocalin)/ Creatinine Ratio

Intervention	Participants (Count of Participants)
Aminophylline	11
Control	14

urinary NGAL(Neutrophil gelatinase-associated lipocalin) is a biomarker for kidney injury. NGAL levels 12h post-transplant were found to be a marker for development of delayed graft function and need for dialysis post-transplant. NGAL levels are corrected for urine creatinine. (NCT01759862)
Timeframe: 12 hours post transplant

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Health benefits of methylxanthines in neurodegenerative diseases. Molecular nutrition & food research, 2017, Volume: 61, Issue:6 Topics: Animals; Cacao; Caffeine; Coffee; Disease Models, Animal; Humans; Ilex paraguariensis; Meta-Analysis	2017
Recovery of respiratory activity after C2 hemisection (C2HS): involvement of adenosinergic mechanisms. Respiratory physiology & neurobiology, 2009, Nov-30, Volume: 169, Issue:2 Topics: Animals; Cervical Vertebrae; Disease Models, Animal; Drug Administration Schedule; Functional Latera	2009
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Adenosinergic mechanisms underlying recovery of diaphragm motor function following upper cervical spinal cord injury: potential therapeutic implications. Neurological research, 2005, Volume: 27, Issue:2 Topics: Animals; Diaphragm; Disease Models, Animal; Electromyography; Functional Laterality; Neural Networks	2005
The role of theophylline and phosphodiesterase4 isoenzyme inhibitors as anti-inflammatory drugs. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1998, Volume: 28 Suppl 3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents; Asthma; Cyclic Nucleotide Ph	1998
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Catecholamine-mediated arrhythmias in acute myocardial infarction. Experimental evidence and role of beta-adrenoceptor blockade. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Nov-24, Volume: 56, Issue:22 Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Catecholamines; Cats; Coronary Disease;	1979
The thymus-dependent immune system in the pathogenesis of type 1 (insulin-dependent) diabetes mellitus. Animal model and human studies. Danish medical bulletin, 1985, Volume: 32, Issue:3 Topics: Animals; Antibodies, Viral; Cyclophosphamide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty	1985
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Article	Year
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membr	2008
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. Bioorganic & medicinal chemistry, 2015, May-15, Volume: 23, Issue:10 Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrie	2015
Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 2019, 07-10, Volume: 11, Issue:500 Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S	2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr	2020
Effect of doxofylline on pulmonary inflammatory response and oxidative stress during mechanical ventilation in rats with COPD. BMC pulmonary medicine, 2022, Feb-17, Volume: 22, Issue:1 Topics: Animals; Disease Models, Animal; Inflammation; Interleukin-10; Male; Oxidative Stress; Pulmonary Dis	2022
Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis. Fundamental & clinical pharmacology, 2023, Volume: 37, Issue:2 Topics: Albuterol; Animals; Budesonide; Cytokines; Disease Models, Animal; Gene Expression; Male; Mice; Mice	2023
Impacts of anti-inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation. Pharmacology research & perspectives, 2021, Volume: 9, Issue:4 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Benzamides; Cyclopropanes; Disease Models, Animal	2021
The effect of theophylline on acetic acid induced ulcerative colitis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 90 Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Disease Models, Animal;	2017
Steroid sparing effects of doxofylline. Pulmonary pharmacology & therapeutics, 2018, Volume: 48 Topics: Animals; Bronchodilator Agents; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, D	2018
Nicorandil and theophylline can protect experimental rats against complete Freund's adjuvant-induced rheumatoid arthritis through modulation of JAK/STAT/RANKL signaling pathway. European journal of pharmacology, 2018, Mar-05, Volume: 822 Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Female; Freund's Adjuvant; Janus Kinases; Jo	2018
Lipotoxicity-associated inflammation is prevented by guarana ( Drug and chemical toxicology, 2021, Volume: 44, Issue:5 Topics: Adenosine; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Caffeine; Disease Models, Anim	2021
Remote cardioprotection by transfer of coronary effluent from ischemic preconditioned rabbit heart preserves mitochondrial integrity and function via adenosine receptor activation. Cardiovascular drugs and therapy, 2014, Volume: 28, Issue:1 Topics: Adenosine; Animals; Disease Models, Animal; Ischemic Preconditioning, Myocardial; Male; Mitochondria	2014
Theophylline inhibits the cough reflex through a novel mechanism of action. The Journal of allergy and clinical immunology, 2014, Volume: 133, Issue:6 Topics: Action Potentials; Animals; Antitussive Agents; Calcium; Capsaicin; Cough; Disease Models, Animal; G	2014
Doxofylline, a novofylline inhibits lung inflammation induced by lipopolysacharide in the mouse. Pulmonary pharmacology & therapeutics, 2014, Volume: 27, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Bronchodilator Agents; Cell Movement; Disease Models, Animal; Dos	2014
Theophylline improves lipopolysaccharide-induced alveolarization arrest through inflammatory regulation. Molecular medicine reports, 2014, Volume: 10, Issue:1 Topics: Animals; Animals, Newborn; Bronchodilator Agents; Bronchopulmonary Dysplasia; Chemokine CCL3; Chemok	2014
Novel tricyclic[2,1-f]theophylline derivatives of LCAP with activity in mouse models of affective disorders. The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:12 Topics: Animals; Antipsychotic Agents; Behavior, Animal; Dextroamphetamine; Disease Models, Animal; Male; Me	2014
Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones. Pharmacological reports : PR, 2014, Volume: 66, Issue:6 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Formaldeh	2014
Translating drug-induced hibernation to therapeutic hypothermia. ACS chemical neuroscience, 2015, Jun-17, Volume: 6, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Body Temperature; CA1 Region, Hippocampal; Cell	2015
Protective effect of theophylline on renal functions in experimental pneumoperitoneum model. Renal failure, 2015, Volume: 37, Issue:6 Topics: Acute Kidney Injury; Animals; Biomarkers; Biopsy, Needle; Creatine; Cystatin C; Disease Models, Anim	2015
Acute theophylline exposure modulates breathing activity through a cervical contusion. Experimental neurology, 2015, Volume: 271 Topics: Analysis of Variance; Animals; Diaphragm; Disease Models, Animal; Electromyography; Evoked Potential	2015
Antinociceptive effects of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis, and possible involvement of the adenosine system. Scientific reports, 2015, Nov-03, Volume: 5 Topics: Adenosine; Alkaloids; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Bignoniaceae; Disease	2015
Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats. Brain research bulletin, 2016, Volume: 124 Topics: Adenosine A2 Receptor Antagonists; Animals; Anticonvulsants; Cyclooxygenase Inhibitors; Disease Mode	2016
Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats. Neuroscience research, 2009, Volume: 65, Issue:2 Topics: Adenosine; Afferent Pathways; Animals; Cerebral Arteries; Cerebrovascular Circulation; Dental Pulp C	2009
Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice. Journal of Alzheimer's disease : JAD, 2009, Volume: 17, Issue:3 Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of V	2009
Differential effects of adenosine antagonists in two models of parkinsonian tremor. Pharmacology, biochemistry, and behavior, 2009, Volume: 94, Issue:1 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Caffeine;	2009
Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation. Transplant international : official journal of the European Society for Organ Transplantation, 2010, Volume: 23, Issue:2 Topics: Animals; Apoptosis; Benzophenanthridines; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; E	2010
Theophylline induces changes in the electro-olfactogram of the mouse. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2010, Volume: 267, Issue:2 Topics: Administration, Intranasal; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; E	2010
Adenosine A1 receptor blockage mediates theophylline-associated seizures. Epilepsia, 2010, Volume: 51, Issue:3 Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine Kinase; Anim	2010
Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circulation. Arrhythmia and electrophysiology, 2009, Volume: 2, Issue:6 Topics: Adrenergic Agonists; Animals; Animals, Newborn; Calcium Signaling; Cardiac Pacing, Artificial; Disea	2009
Development of cigarette smoke solution- and lipopolysaccharide-induced pulmonary emphysema in guinea pigs. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2010, Volume: 135, Issue:1 Topics: Airway Resistance; Animals; Bronchodilator Agents; Disease Models, Animal; Guinea Pigs; Lipopolysacc	2010
A distinct nitric oxide and adenosine A1 receptor dependent hepatic artery vasodilatatory response in the CCl-cirrhotic liver. Liver international : official journal of the International Association for the Study of the Liver, 2010, Volume: 30, Issue:7 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Blotting, Western; Caffeine; Carbon Tetrachlo	2010
Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice. Sleep, 2010, Volume: 33, Issue:7 Topics: Animals; Ataxin-3; Benzhydryl Compounds; Body Temperature; Caffeine; Central Nervous System Stimulan	2010
Endogenous adenosine A1 receptor activation underlies the transient post-ischemic rhythmic delta EEG activity. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2011, Volume: 122, Issue:6 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Delta Rhythm; Disease Models, Animal; Electro	2011
An alternative antidote therapy in amitriptyline-induced rat toxicity model: theophylline. Drug and chemical toxicology, 2011, Volume: 34, Issue:1 Topics: Amitriptyline; Animals; Antidotes; Blood Gas Analysis; Blood Pressure; Carbon Dioxide; Disease Model	2011
Intratracheal sensitization/challenge-induced biphasic asthmatic response and airway hyperresponsiveness in guinea pigs. Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:12 Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Antigens; Asthma; Bronchial Hyperreactivity; Chro	2010
Inhibition of HBV replication by theophylline. Antiviral research, 2011, Volume: 89, Issue:2 Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; DNA, Viral; Hepatitis B; Hepatitis B S	2011
Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer's mice. Journal of Alzheimer's disease : JAD, 2011, Volume: 25, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim	2011
Design and synthesis of some new theophylline derivatives with bronchodilator and antibacterial activities. Archives of pharmacal research, 2011, Volume: 34, Issue:1 Topics: Aminophylline; Ampicillin; Animals; Anti-Bacterial Agents; Asthma; Bronchial Spasm; Bronchodilator A	2011
Synergic bronchodilator effects of a phosphodiesterase 3 inhibitor olprinone with a volatile anaesthetic sevoflurane in ovalbumin-sensitised guinea pigs. European journal of anaesthesiology, 2011, Volume: 28, Issue:7 Topics: Acetylcholine; Airway Resistance; Anesthetics, Inhalation; Animals; Bronchial Hyperreactivity; Bronc	2011
Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels. Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:10 Topics: Adenosine; Animals; Cardiotonic Agents; Cilostazol; Decanoic Acids; Disease Models, Animal; Drug Eva	2011
The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats. Acta neurobiologiae experimentalis, 2011, Volume: 71, Issue:2 Topics: Action Potentials; Adenosine; Animals; Brain Waves; Disease Models, Animal; Drug Interactions; Elect	2011
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Evidence of functional impairment of syngeneically transplanted mouse pancreatic islets retrieved from the liver. Diabetes, 2004, Volume: 53, Issue:4 Topics: Animals; Cell Separation; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose; Humans;	2004
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Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury. Cellular and molecular biology (Noisy-le-Grand, France), 2007, Jan-21, Volume: 52 Suppl Topics: Adenosine; Animals; Arginine; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Enzyme Inh	2007
Differential expression of adenosine A1 and A2A receptors after upper cervical (C2) spinal cord hemisection in adult rats. The journal of spinal cord medicine, 2007, Volume: 30, Issue:4 Topics: Administration, Oral; Analysis of Variance; Animals; Cervical Vertebrae; Disease Models, Animal; Fem	2007
Epileptogenesis factors with regard to oxidative stress and theophylline administration. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2008, Volume: 75, Issue:1 Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Glutathione; Glutathione P	2008
Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system. Journal of pharmacological sciences, 2008, Volume: 106, Issue:4 Topics: Aminoglutethimide; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Resp	2008
Islet secretion in a new experimental model for non-insulin-dependent diabetes. Diabetes, 1981, Volume: 30, Issue:7 Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucagon; Glucos	1981
Effect of calcium antagonists in experimental asthma. Allergy, 1982, Volume: 37, Issue:7 Topics: Anaphylaxis; Animals; Asthma; Calcium Channel Blockers; Depression, Chemical; Disease Models, Animal	1982
Evidence for role of cyclic AMP as second messenger of arrhythmogenic effects of beta-stimulation. Advances in cyclic nucleotide research, 1980, Volume: 12 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Bucladesine; Coronary Disease; Cyclic AMP; Disease	1980
Effect of therapeutic agents on acute ocular toxicity of methyl alcohol (an experimental study). Indian journal of ophthalmology, 1983, Volume: 31, Issue:5 Topics: Acute Disease; Animals; Dexamethasone; Disease Models, Animal; Eye Diseases; Macaca mulatta; Methano	1983
Effect of aminophylline on coronary reactive and functional hyperaemic response in conscious dogs. Cardiovascular research, 1984, Volume: 18, Issue:6 Topics: Aminophylline; Animals; Coronary Vessels; Disease Models, Animal; Dogs; Heart Block; Oxygen; Regiona	1984
Pharmacokinetics of theophylline: effects of hepatic fibrosis in rats induced bile duct ligation. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:3 Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Ducts; Biliru	1995
Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs. European journal of pharmacology, 1995, Feb-24, Volume: 275, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Analysis of Variance; Animals; Asth	1995
Acadesine improves tolerance to ischemic injury in rat cardiac myocytes. Journal of molecular and cellular cardiology, 1994, Volume: 26, Issue:9 Topics: Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Female; Heart; In Vitro Techniques; Myo	1994
Correlation of drug pharmacokinetics and effectiveness of multiple-dose activated charcoal therapy. Annals of emergency medicine, 1995, Volume: 25, Issue:3 Topics: Acetaminophen; Animals; Charcoal; Digoxin; Disease Models, Animal; Drug Administration Schedule; Fem	1995
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus. Journal of cellular biochemistry, 1994, Volume: 56, Issue:4 Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease M	1994
Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo. The Journal of clinical investigation, 1994, Volume: 94, Issue:4 Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Aspirin; Bloo	1994
Pharmacological modulation of immediate and late airway response and leukocyte infiltration in the guinea pig. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3 Topics: Acetylcholine; Airway Resistance; Animals; Antibodies; Asthma; Benzoquinones; Bronchoalveolar Lavage	1994
Cerebral blood flow and metabolism during repeated asphyxias in newborn piglets: influence of theophylline. Biology of the neonate, 1994, Volume: 65, Issue:3-4 Topics: Animals; Animals, Newborn; Asphyxia; Asphyxia Neonatorum; Brain; Cerebrovascular Circulation; Diseas	1994
Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs. Allergy, 1993, Volume: 48, Issue:8 Topics: Albuterol; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoa	1993
Effects of adenosine on rate-dependent atrioventricular nodal function. Potential roles in tachycardia termination and physiological regulation. Circulation, 1993, Volume: 88, Issue:6 Topics: Adenosine; Animals; Atrioventricular Node; Cardiac Pacing, Artificial; Disease Models, Animal; Elect	1993
Adenosine contributes to neutrophil-mediated loss of myocardial function in post-ischemic guinea-pig hearts. Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:8 Topics: Adenosine; Adenosine Deaminase; Animals; Blood Flow Velocity; Cardiac Output; Coronary Circulation;	1993
Effect of pretreatment with anticonvulsants on theophylline-induced seizures in the rat. Journal of critical care, 1993, Volume: 8, Issue:4 Topics: Animals; Anticonvulsants; Brain Chemistry; Chromatography, High Pressure Liquid; Disease Models, Ani	1993
Preconditioning enhances myocardial resistance to postischaemic myocardial stunning via adenosine receptor activation. Cardiovascular research, 1993, Volume: 27, Issue:4 Topics: Animals; Disease Models, Animal; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reper	1993
Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart. Cardiovascular research, 1993, Volume: 27, Issue:4 Topics: Adenosine; Animals; Coronary Circulation; Disease Models, Animal; Male; Myocardial Contraction; Myoc	1993
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. British journal of pharmacology, 1993, Volume: 108, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Cyclic Nuc	1993
Pyridoxine as therapy in theophylline-induced seizures. Veterinary and human toxicology, 1995, Volume: 37, Issue:4 Topics: Aminophylline; Animals; Bronchodilator Agents; Disease Models, Animal; Electroencephalography; Femal	1995
Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats. Toxicology, 1996, Jun-17, Volume: 110, Issue:1-3 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bronchodilator Agents; Calcium; Calcium Channel Block	1996
Role of calbindin-D9k in buffering cytosolic free Ca2+ ions in pig duodenal enterocytes. The Journal of physiology, 1996, May-01, Volume: 492 ( Pt 3) Topics: Animals; Biological Transport, Active; Calbindins; Calcitriol; Calcium; Cell Survival; Cholecalcifer	1996
Anti-inflammatory effects of theophylline, cromolyn and salbutamol in a murine model of pleurisy. British journal of pharmacology, 1996, Volume: 118, Issue:3 Topics: Albuterol; Animals; Cromolyn Sodium; Disease Models, Animal; Dose-Response Relationship, Drug; Femal	1996
Simultaneous measurement of cyclopentyladenosine-induced contraction and intracellular calcium in bronchial rings from allergic rabbits and it's antagonism. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:2 Topics: Adenosine; Animals; Bronchi; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Musc	1996
Islet amyloid polypeptide (IAPP) secretion from pancreatic islets isolated from non-obese diabetic (NOD) mice. Regulatory peptides, 1996, May-07, Volume: 63, Issue:1 Topics: Amyloid; Animals; Cattle; Culture Techniques; Diabetes Mellitus, Type 1; Disease Models, Animal; DNA	1996
Prevention of radiocontrast-induced nephropathy by adenosine antagonists in rats with chronic nitric oxide deficiency. Journal of the American Society of Nephrology : JASN, 1997, Volume: 8, Issue:7 Topics: Acute Kidney Injury; Adenosine; Animals; Blood Pressure; Contrast Media; Disease Models, Animal; Enz	1997
Effect of adenosine and histamine receptor stimulation on canine histamine release to pentagastrin. Digestion, 1997, Volume: 58, Issue:4 Topics: Adenosine; Animals; Dimaprit; Disease Models, Animal; Dogs; Female; Gas Chromatography-Mass Spectrom	1997
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity. Journal of cardiac failure, 1997, Volume: 3, Issue:3 Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Ani	1997
A comparative study of aminophylline- and acepifylline-induced seizures and death in the chemoconvulsion model in rats. The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:8 Topics: Aminophylline; Animals; Bronchodilator Agents; Convulsants; Disease Models, Animal; Drug Interaction	1997
Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. Methods and findings in experimental and clinical pharmacology, 1997, Volume: 19, Issue:5 Topics: 2-Chloroadenosine; Adenosine; Animals; Anticonvulsants; Carbamazepine; Dipyridamole; Disease Models,	1997
Adenosine receptor antagonism affects regional resting vascular resistance during rat peritoneal sepsis. The Journal of surgical research, 1998, Volume: 80, Issue:2 Topics: Adenosine; Animals; Cardiac Output; Disease Models, Animal; Hemodynamics; Male; Organ Specificity; P	1998
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain. European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3 Topics: Adenosine Kinase; Animals; Anti-Bacterial Agents; Blood Glucose; Body Weight; Diabetes Mellitus, Exp	1999
Endogenous adenosine protects CA1 neurons from kainic acid-induced neuronal cell loss in the rat hippocampus. The European journal of neuroscience, 1999, Volume: 11, Issue:10 Topics: Adenosine; Animals; Apoptosis; Disease Models, Animal; Excitatory Amino Acid Agonists; Glial Fibrill	1999
Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2000, Volume: 47, Issue:3 Topics: Adrenergic Agonists; Adrenergic beta-Antagonists; Aminophylline; Analysis of Variance; Anesthetics,	2000
N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:4 Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, An	2000
Effect of theophylline and trimethobenzamide when given during kainate-induced status epilepticus: an improved histopathologic rat model of human hippocampal sclerosis. Epilepsia, 2000, Volume: 41, Issue:11 Topics: Animals; Benzamides; Brain Diseases; Cell Count; Disease Models, Animal; Epilepsy, Temporal Lobe; Hi	2000
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats. Brain research, 2001, Jun-29, Volume: 905, Issue:1-2 Topics: Adenosine Kinase; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibito	2001
Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia. British journal of pharmacology, 2001, Volume: 134, Issue:2 Topics: Adenosine; Animals; Caffeine; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug;	2001
Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats. Autonomic neuroscience : basic & clinical, 2000, Oct-02, Volume: 83, Issue:3 Topics: Adenosine; Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dipyridamole; Disea	2000
Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. Pharmacology, 2002, Volume: 65, Issue:3 Topics: Adenosine; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug	2002
Mimickry of anti-granuloma effect of prostaglandin E by dibutyryl cyclic-AMP and some phosphodiesterase inhibitors. Agents and actions. Supplements, 1979, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Anti-Inflammatory Agents; Bucladesine; Disease Models, Animal;	1979
Metabolic studies in the pyelonephritic rat. Diabetes, 1975, Volume: 24, Issue:10 Topics: Adipose Tissue; Animals; Body Weight; Creatinine; Diet; Disease Models, Animal; Epinephrine; Fatty A	1975
Development of an animal model of late asthmatic response in guinea pigs and effects of anti-asthmatic drugs. Prostaglandins, 1992, Volume: 43, Issue:6 Topics: Albuterol; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cromolyn Sodium; Cytodiagnosis;	1992
Role of adenosine receptor activation in myocardial infarct size limitation by ischaemic preconditioning. Cardiovascular research, 1992, Volume: 26, Issue:5 Topics: Animals; Disease Models, Animal; Hemodynamics; Male; Myocardial Infarction; Myocardium; Phenylisopro	1992
Model of bronchial allergic inflammation in the brown Norway rat. Pharmacological modulation. International journal of immunopharmacology, 1992, Volume: 14, Issue:5 Topics: Albuterol; Animals; Bronchitis; Dexamethasone; Disease Models, Animal; Ketotifen; Male; Ovalbumin; R	1992
A potential animal model for studying CF heterozygote advantage: genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice. Biochemical medicine and metabolic biology, 1992, Volume: 47, Issue:1 Topics: Animals; Chlorides; Colon; Cystic Fibrosis; Disease Models, Animal; Electric Conductivity; Female; G	1992
Dissociation between the effects of theophylline and caffeine on premature airway smooth muscles. Pediatric research, 1991, Volume: 29, Issue:5 Topics: Acetylcholine; Animals; Animals, Newborn; Caffeine; Disease Models, Animal; Female; Humans; Infant,	1991
Diarrhoea of famine and malnutrition: investigations using a rat model. 1. Jejunal hypersecretion induced by starvation. Gut, 1990, Volume: 31, Issue:1 Topics: Animals; Bethanechol; Bethanechol Compounds; Carbachol; Chlorides; Diarrhea; Disease Models, Animal;	1990
Synthesis and antiallergy activity of N-[2-(dimethylamino)ethyl]-4-aryl-1-piperazinecarboxamide derivatives. Journal of medicinal chemistry, 1990, Volume: 33, Issue:7 Topics: Anaphylaxis; Animals; Dimethylamines; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists;	1990
Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut, 1990, Volume: 31, Issue:2 Topics: Acetylcholine; Animals; Atropine; Bethanechol Compounds; Bicarbonates; Chlorides; Diarrhea; Disease	1990
Influence of endotoxin-induced fever on the pharmacokinetics of theophylline in the rabbit model. Pharmacotherapy, 1989, Volume: 9, Issue:4 Topics: Animals; Disease Models, Animal; Endotoxins; Escherichia coli; Fever; Infusions, Intravenous; Inject	1989
Theophylline prolongs survival and decreases renal damage in female NZB/W F-1 mice. Thymus, 1988, Volume: 11, Issue:4 Topics: Animals; Antibodies, Antinuclear; Disease Models, Animal; Female; Glomerulonephritis; Graft vs Host	1988
Theophylline toxicity and the beta-adrenergic system. Annals of internal medicine, 1985, Volume: 102, Issue:6 Topics: Acidosis; Adolescent; Aminophylline; Animals; Catecholamines; Disease Models, Animal; Dogs; Female;	1985
Actions of bronchodilator drugs, glucocorticoid, and their combinations on airways in rats and guinea pigs. Acta pharmacologica et toxicologica, 1985, Volume: 57 Suppl 3 Topics: Animals; Asthma; Bronchodilator Agents; Disease Models, Animal; Drug Interactions; Female; Glucocort	1985
Adenosine inhibits exocytotic release of endogenous noradrenaline in rat heart: a protective mechanism in early myocardial ischemia. Circulation research, 1987, Volume: 61, Issue:1 Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Coronary Circulation; Coronary Disease; Di	1987
Intravenous theophylline poisoning and multiple-dose charcoal in an animal model. Annals of emergency medicine, 1987, Volume: 16, Issue:8 Topics: Animals; Bile; Charcoal; Disease Models, Animal; Dogs; Infusions, Intravenous; Kinetics; Theophyllin	1987
Kinetics of theophylline clearance in gastrointestinal dialysis with charcoal. Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:7 Topics: Animals; Charcoal; Dialysis; Digestive System; Disease Models, Animal; Kinetics; Metabolic Clearance	1987
Kinetics of drug action in disease states. XVIII. Effect of experimental renal failure on the pharmacodynamics of theophylline-induced seizures in rats. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:2 Topics: Animals; Brain; Disease Models, Animal; Female; Kidney Failure, Chronic; Protein Binding; Rats; Seiz	1987
The diabetic Chinese hamster: in vitro insulin and glucagon release; the ""chemical diabetic";; and the effect of diet on ketonuria. Diabetologia, 1974, Volume: 10 Suppl Topics: Animals; Arginine; Cricetinae; Diabetes Mellitus; Diabetic Ketoacidosis; Disease Models, Animal; Fem	1974
Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic mice. Diabetologia, 1970, Volume: 6, Issue:3 Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Body Weight; Disease Models, Animal; Epididymi	1970
[Experimental asthma in guinea pigs and autonomic mediators]. Journal de physiologie, 1972, Volume: 65 Topics: Animals; Asthma; Atropine; Autonomic Agents; Cyclic AMP; Disease Models, Animal; Guinea Pigs; Hexame	1972
Congenitally impaired hormone sensitivity of the adipose tissue of spontaneously diabetic mice, KK. Validity of thrifty genotype in KK mice. Diabetologia, 1974, Volume: 10 Suppl Topics: Adipose Tissue; Animals; Concanavalin A; Cyclic AMP; Diabetes Mellitus; Disease Models, Animal; Epin	1974
Evidence for decreased sensitivity to glucose of isolated islets from spiny mice. (Acomys cahirinus). Diabetologia, 1974, Volume: 10 Suppl Topics: Animals; Antigens; Arginine; Cyclic AMP; Cytochalasin B; Diabetes Mellitus; Disease Models, Animal;	1974
Quasi morphine-abstinence syndrome. Nature, 1974, May-31, Volume: 249, Issue:456 Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Delayed-Action Preparations; Disease Models, Animal;	1974
[New viewpoints in therapy using vasoactive drugs]. Die Medizinische Welt, 1974, Sep-06, Volume: 25, Issue:36 Topics: Amino Alcohols; Animals; Blood; Blood Vessels; Disease Models, Animal; Ethanol; Guinea Pigs; Microci	1974
Abnormal secretion of insulin and glucagon by the in vitro perfused pancreas of the genetically diabetic Chinese hamster. The Journal of clinical investigation, 1974, Volume: 53, Issue:6 Topics: Animals; Blood Glucose; Cattle; Cricetinae; Diabetes Mellitus; Disease Models, Animal; Drug Combinat	1974
[Influence of xanthinol nicotinate on hyperlactacidemia induced by epinephrine and norepinephrine]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:12 Topics: Animals; Disease Models, Animal; Drug Antagonism; Drug Synergism; Epinephrine; Lactates; Male; Nicot	1970

theophylline and Disease Models, Animal