theophylline has been researched along with Cerebral Ischemia in 29 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative mean transit time (rMTT) in the infarct core, penumbra, and unaffected tissue were measured using multi-parametric MRI at baseline and 3‑h follow-up in patients treated with theophylline or placebo as an add-on to thrombolytic therapy." | 9.51 | Perfusion Changes in Acute Stroke Treated with Theophylline as an Add-on to Thrombolysis : A Randomized Clinical Trial Subgroup Analysis. ( Andersen, G; Fiehler, J; Forkert, ND; Hjort, N; Modrau, B; Nygård Johansen, M; Vorum, H; Winder, A, 2022) |
| "The objective of this review was to assess the effect of theophylline and its analogues, aminophylline and caffeine, in people with confirmed or presumed acute ischaemic stroke." | 8.82 | Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke. ( Bath, PM, 2004) |
| "The objective of this review was to assess the effect of theophylline and its analogues (aminophylline and caffeine) in people with confirmed or presumed acute ischaemic stroke." | 8.80 | Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke. ( Bath, FJ; Bath, PM; Mohiuddin, AA, 2000) |
| "The TEA-Stroke trial (The Theophylline in Acute Ischemic Stroke) was an investigator-initiated 2-center, proof-of-concept, phase II clinical study with a randomized, double-blinded, placebo-controlled design." | 7.96 | Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. ( Andersen, G; Bach, FW; Eskildsen, HW; Hansen, MB; Hjort, N; Johansen, MB; Mikkelsen, IK; Modrau, B; Mouridsen, K; Nielsen, A; Povlsen, JP; Yavarian, Y; Østergaard, L, 2020) |
| "The neuroprotective role of endogenous adenosine during forebrain ischemia elicited by 4-vessel occlusion in rats was assessed using the adenosine antagonist, theophylline (32 mg/kg)." | 7.68 | Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia. ( Allix, M; Boulu, RG; Callebert, J; Lekieffre, D; Plotkine, M, 1991) |
| "The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative mean transit time (rMTT) in the infarct core, penumbra, and unaffected tissue were measured using multi-parametric MRI at baseline and 3‑h follow-up in patients treated with theophylline or placebo as an add-on to thrombolytic therapy." | 5.51 | Perfusion Changes in Acute Stroke Treated with Theophylline as an Add-on to Thrombolysis : A Randomized Clinical Trial Subgroup Analysis. ( Andersen, G; Fiehler, J; Forkert, ND; Hjort, N; Modrau, B; Nygård Johansen, M; Vorum, H; Winder, A, 2022) |
| "The objective of this review was to assess the effect of theophylline and its analogues, aminophylline and caffeine, in people with confirmed or presumed acute ischaemic stroke." | 4.82 | Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke. ( Bath, PM, 2004) |
| "The objective of this review was to assess the effect of theophylline and its analogues (aminophylline and caffeine) in people with confirmed or presumed acute ischaemic stroke." | 4.80 | Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke. ( Bath, FJ; Bath, PM; Mohiuddin, AA, 2000) |
| "The TEA-Stroke trial (The Theophylline in Acute Ischemic Stroke) was an investigator-initiated 2-center, proof-of-concept, phase II clinical study with a randomized, double-blinded, placebo-controlled design." | 3.96 | Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. ( Andersen, G; Bach, FW; Eskildsen, HW; Hansen, MB; Hjort, N; Johansen, MB; Mikkelsen, IK; Modrau, B; Mouridsen, K; Nielsen, A; Povlsen, JP; Yavarian, Y; Østergaard, L, 2020) |
| "5% O2), to topical adenosine (10[-5] and 10[-4] mol/L) and to arterial hypercapnia (inhalation of 5% and 10% CO2 in air) before and after 10 minutes of global ischemia." | 3.70 | Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. ( Bari, F; Busija, DW; Louis, TM, 1998) |
| "The purpose of this study was to determine the effects of adenosine agonists and an antagonist on ischemia-induced extracellular glutamate concentrations in an animal model of transient cerebral ischemia using in vivo cerebral microdialysis." | 3.70 | Effects of adenosine agonists and an antagonist on excitatory transmitter release from the ischemic rabbit hippocampus. ( Martinez-Tica, JF; Zornow, MH, 2000) |
| "The neuroprotective role of endogenous adenosine during forebrain ischemia elicited by 4-vessel occlusion in rats was assessed using the adenosine antagonist, theophylline (32 mg/kg)." | 3.68 | Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia. ( Allix, M; Boulu, RG; Callebert, J; Lekieffre, D; Plotkine, M, 1991) |
| "We investigated the influence of the adenosine antagonist theophylline on the degree of hippocampal cell damage in the Mongolian gerbil following brief periods of forebrain ischemia." | 3.67 | Effect of theophylline on ischemically induced hippocampal damage in Mongolian gerbils: a behavioral and histopathological study. ( Hinze, HJ; Keil, M; Rudolphi, KA, 1987) |
| "Moderate hyperglycemia was achieved by administering 17% D-glucose (3 g/kg i." | 1.29 | Effects of theophylline and cyclohexyladenosine on brain injury following normo- and hyperglycemic ischemia: a histopathologic study in the rat. ( Hsu, SS; Meno, JR; Winn, HR; Zhou, JG, 1994) |
| "Adenosine, which also increases during cerebral ischemia, is proposed to inhibit neurotransmitter release." | 1.28 | Adenosine receptor blockade augments interstitial fluid levels of excitatory amino acids during cerebral ischemia. ( Grabb, MC; Roche, FM; Sciotti, VM; Van Wylen, DG, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (17.24) | 18.7374 |
| 1990's | 13 (44.83) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Colotta, V | 3 |
| Catarzi, D | 3 |
| Varano, F | 3 |
| Capelli, F | 1 |
| Lenzi, O | 3 |
| Filacchioni, G | 3 |
| Martini, C | 3 |
| Trincavelli, L | 3 |
| Ciampi, O | 3 |
| Pugliese, AM | 3 |
| Pedata, F | 4 |
| Schiesaro, A | 1 |
| Morizzo, E | 3 |
| Moro, S | 3 |
| Traini, C | 2 |
| Modrau, B | 2 |
| Andersen, G | 2 |
| Mikkelsen, IK | 1 |
| Nielsen, A | 1 |
| Hansen, MB | 1 |
| Johansen, MB | 1 |
| Eskildsen, HW | 1 |
| Povlsen, JP | 1 |
| Yavarian, Y | 1 |
| Mouridsen, K | 1 |
| Østergaard, L | 1 |
| Bach, FW | 1 |
| Hjort, N | 2 |
| Winder, A | 1 |
| Nygård Johansen, M | 1 |
| Fiehler, J | 1 |
| Vorum, H | 1 |
| Forkert, ND | 1 |
| FAZEKAS, JF | 1 |
| ALMAN, RW | 1 |
| TICKTIN, HE | 1 |
| EHRMANTRAUT, WR | 1 |
| SAVARESE, CJ | 1 |
| Bath, PM | 2 |
| Olsson, T | 1 |
| Cronberg, T | 1 |
| Rytter, A | 1 |
| Asztély, F | 1 |
| Fredholm, BB | 2 |
| Smith, ML | 1 |
| Wieloch, T | 2 |
| Benzi, G | 1 |
| Arrigoni, E | 1 |
| Pastoris, O | 1 |
| Raimondo, S | 1 |
| Dossena, M | 1 |
| Fulle, D | 1 |
| Tumminello, MC | 1 |
| Villa, RF | 1 |
| Kozlova, EN | 1 |
| Nikitin, IuM | 1 |
| Strel'tsova, EN | 1 |
| Zhou, JG | 1 |
| Meno, JR | 2 |
| Hsu, SS | 1 |
| Winn, HR | 2 |
| Heron, A | 1 |
| Lasbennes, F | 1 |
| Seylaz, J | 1 |
| Reshef, A | 1 |
| Sperling, O | 1 |
| Zoref-Shani, E | 1 |
| Bari, F | 2 |
| Louis, TM | 2 |
| Busija, DW | 2 |
| Barth, A | 1 |
| Newell, DW | 1 |
| Nguyen, LB | 1 |
| Wender, R | 1 |
| Janigro, D | 1 |
| Bona, E | 1 |
| Adén, U | 1 |
| Gilland, E | 1 |
| Hagberg, H | 1 |
| Latini, S | 1 |
| Bordoni, F | 1 |
| Corradetti, R | 1 |
| Mohiuddin, AA | 1 |
| Bath, FJ | 1 |
| Martinez-Tica, JF | 1 |
| Zornow, MH | 1 |
| Hiraide, T | 1 |
| Katsura, K | 1 |
| Muramatsu, H | 1 |
| Asano, G | 1 |
| Katayama, Y | 1 |
| Tanaka, E | 1 |
| Yasumoto, S | 1 |
| Hattori, G | 1 |
| Niiyama, S | 1 |
| Matsuyama, S | 1 |
| Higashi, H | 1 |
| Sciotti, VM | 1 |
| Roche, FM | 1 |
| Grabb, MC | 1 |
| Van Wylen, DG | 1 |
| Tominaga, K | 1 |
| Shibata, S | 1 |
| Watanabe, S | 1 |
| Dux, E | 1 |
| Schubert, P | 1 |
| Kreutzberg, GW | 1 |
| Lekieffre, D | 1 |
| Callebert, J | 1 |
| Plotkine, M | 1 |
| Allix, M | 1 |
| Boulu, RG | 1 |
| von Lubitz, DK | 1 |
| Marangos, PJ | 1 |
| Blomqvist, P | 1 |
| Lindvall, O | 1 |
| Stenevi, U | 1 |
| Rudolphi, KA | 1 |
| Keil, M | 1 |
| Hinze, HJ | 1 |
3 reviews available for theophylline and Cerebral Ischemia
| Article | Year |
|---|---|
CURRENT THERAPEUTIC CONCEPTS OF CEREBRAL AND MYOCARDIAL VASCULAR DISEASE.
Topics: Acetazolamide; Anticoagulants; Brain Ischemia; Cerebrovascular Disorders; Coronary Disease; Histamin | 1964 |
Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke.
Topics: Aminophylline; Brain Ischemia; Caffeine; Humans; Randomized Controlled Trials as Topic; Stroke; Theo | 2004 |
Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke.
Topics: Aminophylline; Brain Ischemia; Caffeine; Humans; Stroke; Theophylline; Vasodilator Agents | 2000 |
1 trial available for theophylline and Cerebral Ischemia
| Article | Year |
|---|---|
Perfusion Changes in Acute Stroke Treated with Theophylline as an Add-on to Thrombolysis : A Randomized Clinical Trial Subgroup Analysis.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Humans; Infarction; Magnetic Resonance Imaging | 2022 |
25 other studies available for theophylline and Cerebral Ischemia
| Article | Year |
|---|---|
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Benzamides; Brain Ischemia; Cerebral Cortex; CHO Cells; | 2007 |
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membr | 2008 |
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Cattle; Cell Line; Cerebral Cortex; Corp | 2009 |
Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Ischemia; Male; Middle | 2020 |
Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro.
Topics: Adenosine A1 Receptor Antagonists; Animals; Brain Ischemia; Excitatory Postsynaptic Potentials; Hipp | 2004 |
Drug interference on some biochemical parameters of rat cerebral cortex during post-ischemic recovery.
Topics: Alanine; Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Dihydroergotoxine; Energy Transfer; | 1980 |
[Use of thermography and ultrasound dopplerography for evaluating efficacy of complamin in the treatment of patients with disorders of cerebral circulation].
Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Humans; Male; Theophylline; Thermography; Time F | 1981 |
Effects of theophylline and cyclohexyladenosine on brain injury following normo- and hyperglycemic ischemia: a histopathologic study in the rat.
Topics: Adenosine; Animals; Blood Pressure; Brain; Brain Ischemia; Hyperglycemia; Male; Osmolar Concentratio | 1994 |
Adenosine modulation of amino acid release in rat hippocampus during ischemia and veratridine depolarization.
Topics: Adenosine; Amino Acids; Animals; Brain Ischemia; Dialysis; Hippocampus; Infusions, Parenteral; Male; | 1993 |
Preconditioning of primary rat neuronal cultures against ischemic injury: characterization of the "time window of protection'.
Topics: Animals; Brain Ischemia; Cells, Cultured; Iodoacetates; Iodoacetic Acid; Ischemic Preconditioning; L | 1996 |
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excit | 1997 |
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br | 1997 |
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Body Temperature; Body Weight; Brain; | 1997 |
Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets.
Topics: Adenosine; Adenosine Triphosphate; Administration, Topical; Analysis of Variance; Animals; Arteriole | 1998 |
Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices.
Topics: Adenosine; Animals; Brain Ischemia; Extracellular Space; Hippocampus; In Vitro Techniques; Kinetics; | 1999 |
Effects of adenosine agonists and an antagonist on excitatory transmitter release from the ischemic rabbit hippocampus.
Topics: Adenosine; Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Electroencephalography; Ex | 2000 |
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil.
Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Free Radical Scavengers; Gerbillinae; Hippocampus; Isch | 2001 |
Mechanisms underlying the depression of evoked fast EPSCs following in vitro ischemia in rat hippocampal CA1 neurons.
Topics: Animals; Brain Ischemia; Calcium; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniqu | 2001 |
Adenosine receptor blockade augments interstitial fluid levels of excitatory amino acids during cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Glutamates; Glutamic Acid; Hypo | 1992 |
A neuroprotective effect of adenosine A1-receptor agonists on ischemia-induced decrease in 2-deoxyglucose uptake in rat hippocampal slices.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain Ischemia; Deoxyglucose; Hippocampus; In | 1992 |
Ultrastructural localization of calcium in ischemic hippocampal slices: the influence of adenosine and theophylline.
Topics: Adenosine; Animals; Brain Ischemia; Calcium; Dendrites; Hippocampus; Male; Mitochondria; Organ Cultu | 1992 |
Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia.
Topics: Adenosine; Amino Acids; Animals; Brain Ischemia; Dialysis; Male; Prosencephalon; Psychomotor Perform | 1991 |
Cerebral ischemia in gerbils: postischemic administration of cyclohexyl adenosine and 8-sulfophenyl-theophylline.
Topics: Adenosine; Animals; Blood Pressure; Brain Ischemia; Drug Interactions; Female; Gerbillinae; Theophyl | 1990 |
Cyclic AMP concentrations in rat neocortex and hippocampus during and following incomplete ischemia: effects of central noradrenergic neurons, prostaglandins, and adenosine.
Topics: Adenosine; Animals; Brain Ischemia; Cerebral Cortex; Cyclic AMP; Energy Metabolism; Fatty Acids, Non | 1985 |
Effect of theophylline on ischemically induced hippocampal damage in Mongolian gerbils: a behavioral and histopathological study.
Topics: Adenosine; Animals; Behavior, Animal; Brain Ischemia; Cerebrovascular Circulation; Gerbillinae; Hipp | 1987 |