theophylline and Cardiovascular Diseases studies

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

Excerpt	Relevance	Reference
"Asthmatic patients receiving montelukast and, to some extent, low-dose theophylline have lower levels of CVD-associated inflammatory biomarkers and lipid levels."	9.12	The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. ( Allayee, H; Conti, DV; Hartiala, J; Irvin, CG; Lee, W; Lima, JJ; Mehrabian, M, 2007)
"Theophylline is a useful drug for the treatment of asthma."	7.73	A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD. ( Adachi, M; Fukuda, T; Kihara, N; Makino, S; Miyamoto, T; Nakajima, S; Nishima, S; Ohta, K, 2006)
"Asthmatic patients receiving montelukast and, to some extent, low-dose theophylline have lower levels of CVD-associated inflammatory biomarkers and lipid levels."	5.12	The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. ( Allayee, H; Conti, DV; Hartiala, J; Irvin, CG; Lee, W; Lima, JJ; Mehrabian, M, 2007)
"Theophylline is a useful drug for the treatment of asthma."	3.73	A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD. ( Adachi, M; Fukuda, T; Kihara, N; Makino, S; Miyamoto, T; Nakajima, S; Nishima, S; Ohta, K, 2006)
"Theophylline has long been a cornerstone of bronchodilator therapy for asthma and chronic obstructive lung disease, but until recently its use carried the risk of serious, even fatal, toxicity."	3.67	Theophylline therapy. Titrating dosage requirements. ( Uden, DL; Wyatt, RA; Zaske, DE, 1984)
"Some recent epidemiologic studies have reported a nonlinear dose-response in the relationship between coffee consumption and health risks, such that the risks increase disproportionately to the increase in dose."	2.67	Dose-dependency of caffeine metabolism with repeated dosing. ( Benowitz, NL; Brown, CR; Denaro, CP; Jacob, P; Wilson, M, 1990)
"Aminophylline therapy has undergone change in the past decade."	2.37	Aminophylline toxicity. ( Albert, S, 1987)
"Theophylline was the main drug prescribed to in-patients discharged from hospital, although inhaling beta 2-agonists were also recommended in few cases."	1.30	[Respiratory medicine in the aged. Therapeutic problemsd]. ( Cossi, S; De Martinis, M; Ghisla, MK; Grassi, V; Leonardi, R; Tomasi, MF, 1997)
"Although arrhythmias associated with myocardial infarction are managed primarily with drug therapy, those associated with acute respiratory failure respond best to adequate oxygenation and correction of metabolic and hemodynamic abnormalities."	1.27	Managing asthma and COPD in patients with cardiovascular disease. ( George, RB; Payne, DK, 1985)

Research

Studies (70)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants With Accurate Classification of Irreversible Airflow Obstruction

Timeframe	Studies, this research(%)	All Research%
pre-1990	56 (80.00)	18.7374
1990's	4 (5.71)	18.2507
2000's	9 (12.86)	29.6817
2010's	1 (1.43)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Lee, TA	1
Pickard, AS	1
Au, DH	1
Bartle, B	1
Weiss, KB	1
Chen, Y	1
Tu, JH	1
He, YJ	1
Zhang, W	1
Wang, G	1
Tan, ZR	1
Zhou, G	1
Fan, L	1
Zhou, HH	1
Schudt, C	1
Hatzelmann, A	1
Beume, R	1
Tenor, H	1
BERGER, F	1
CELLI, L	1
MUZIO, L	1
BALZARINI, E	1
HILLER, E	1
THIESS, A	1
OSBORN, DP	1
SACHSSE, B	1
BAMMELUND, E	1
KAISER, R	1
LINKE, H	1
LANG, W	1
PABST, HW	1
SCHWALB, H	1
HENSEL, H	1
MULLER, R	1
SCHILD, W	1
ASCIONE, A	2
VITALE, P	2
LAMPRECHT, G	1
BALDINI, L	1
BRAMBILLA, G	1
CAVALLINI, L	1
BANSE, HJ	1
ZAHNOW, W	1
THURAU, H	1
LANDEN, HC	1
ARQUINT, A	1
BLOECHLINGER, K	1
BOGENMANN, E	1
BARTOUSEK, V	1
BRUCKNER, L	1
CERNY, J	1
DOLECEK, R	1
EISLER, L	1
FALK, G	1
LERCHE, W	1
HUNGER, H	1
BROGLIA, F	1
SPERLING, M	1
MAU, G	1
SCHENNETTEN, FP	1
KUSZTOS, D	1
HAFFNER, Z	1
FEUSER, J	1
LOOS, M	1
WERKO, L	1
LAGERLOF, H	1
TARTARA, A	1
McMICHAEL, J	1
Makino, S	1
Adachi, M	1
Ohta, K	1
Kihara, N	1
Nakajima, S	1
Nishima, S	1
Fukuda, T	1
Miyamoto, T	1
Allayee, H	1
Hartiala, J	1
Lee, W	1
Mehrabian, M	1
Irvin, CG	1
Conti, DV	1
Lima, JJ	1
Nishii, M	1
Izumi, T	1
Sanner, B	1
Schäfer, T	1
Uden, DL	1
Wyatt, RA	1
Zaske, DE	1
Minton, NA	1
Henry, JA	1
Leonardi, R	1
Cossi, S	1
De Martinis, M	1
Ghisla, MK	1
Tomasi, MF	1
Grassi, V	1
Quinn, MJ	1
Fitzgerald, DJ	1
Hirooka, K	1
Shimizu, M	1
Mineshita, S	1
Dini, FL	1
Cogo, R	1
Magazanik, NA	1
Rhomberg, F	1
Denaro, CP	1
Brown, CR	1
Wilson, M	1
Jacob, P	1
Benowitz, NL	1
Sato, S	1
Levy, G	1
Stanley, R	1
Comer, T	1
Taylor, JL	1
Saliba, D	1
Sollevi, A	1
Albert, S	1
George, RB	1
Payne, DK	1
Schulz, FH	1
Hapke, HJ	2
Ruggerini, R	1
Grugni, P	1
Bolognesi, L	1
Romitti, M	1
Poggi, G	1
Senini, G	1
Inga, EF	1
Duchêne-Marullaz, P	1
Lavarenne, J	1
Hartmann, K	1
Van Schepdael, J	1
Solvay, H	1
Molino, N	1
Belluardo, C	1
Molino, S	1
Bross, W	1
Bross, T	1
Kozuszek, W	1
Olejak, B	1
Kustrzycki, A	1
Koltowski, R	1
Meschino, S	1
Meoni, S	1
Massari, F	1
Fontana, F	1
Pelster, C	1
Overbeck, P	1
Bergsdorf, M	1
Erfurth, HJ	1
Görlich, N	1
Neuffer, F	1
Schotten, EW	1
Spohd, H	1
Zettel, G	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparative Effectiveness of COPD Assessment and Management Bundle Versus Usual Care in Patients Suspected of Having COPD[NCT01833026]		56 participants (Actual)	Interventional	2013-03-31	Completed
Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma (REDEFINE Study)[NCT03137303]	Phase 3	402 participants (Actual)	Interventional	2017-07-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

accuracy of diagnosis was the outcome measure. The results of the spirometry test (done in the beginning for the intervention group and ant the end of 1 year for the usual care groups) were reviewed in conjunction with the initial physician diagnosis of COPD and/or asthma to confirm whether the diagnosis was accurate, not accurate, or indeterminate. Accuracy of diagnosis of COPD was determined by spirometry results if the FEV1/FVC ratio was <0.7. (NCT01833026)
Timeframe: spirometry was performed at the first visit for intervention group and at 1 year from recruitment for the usual care group, one time assessment for both groups

Total Number of Healthcare Visits

Intervention	Participants (Count of Participants)
COPD Assessment and Management Recommendations	10
Usual Care	5

Determine differences in healthcare visits which include all-cause and respiratory related, acute care outpatient visits, emergency department visits, and hospitalizations between groups (NCT03137303)
Timeframe: 1 year

Intervention	Participants (Count of Participants)
	Emergency room visit72551318			Emergency room visit72551317	Hospitalization72551317	Hospitalization72551318	Acute outpatient visit72551318	Acute outpatient visit72551317	Routine primary care visits72551317	Routine primary care visits72551318	New diagnostic tests72551318	New diagnostic tests72551317
	No	Missing	Yes
Patient Subject Usual Care	111
Patient-Subject Intervention	76
Patient Subject Usual Care	119
Patient-Subject Intervention	93
Patient Subject Usual Care	1
Patient Subject Usual Care	48
Patient-Subject Intervention	17
Patient Subject Usual Care	182
Patient-Subject Intervention	152
Patient Subject Usual Care	61
Patient-Subject Intervention	35
Patient Subject Usual Care	169
Patient-Subject Intervention	134
Patient Subject Usual Care	198
Patient-Subject Intervention	138
Patient Subject Usual Care	32
Patient-Subject Intervention	31
Patient-Subject Intervention	2
Patient Subject Usual Care	126
Patient-Subject Intervention	72
Patient Subject Usual Care	104
Patient-Subject Intervention	97

Article	Year
Phosphodiesterase inhibitors: history of pharmacology. Handbook of experimental pharmacology, 2011, Issue:204 Topics: Animals; Asthma; Bronchodilator Agents; Cardiovascular Diseases; Humans; Nitric Oxide; Phosphodieste	2011
[Cardiotoxicity of non-cardiac drugs]. Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8 Topics: Anthracyclines; Antineoplastic Agents; Cardiovascular Diseases; Ergotamine; Histamine H2 Antagonists	2007
[Central sleep apnea syndrome]. Deutsche medizinische Wochenschrift (1946), 2008, Volume: 133, Issue:14 Topics: Acetazolamide; Altitude Sickness; Anticonvulsants; Bronchodilator Agents; Cardiovascular Diseases; C	2008
Acute and chronic human toxicity of theophylline. Human & experimental toxicology, 1996, Volume: 15, Issue:6 Topics: Bronchodilator Agents; Cardiovascular Diseases; Central Nervous System Diseases; Drug Monitoring; Ga	1996
Ticlopidine and clopidogrel. Circulation, 1999, Oct-12, Volume: 100, Issue:15 Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angina, Unstable; Aspirin; Bo	1999
Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects. Current medical research and opinion, 2001, Volume: 16, Issue:4 Topics: Animals; Arrhythmias, Cardiac; Asthma; Bronchodilator Agents; Cardiovascular Diseases; Drug Evaluati	2001
Cardiovascular effects of adenosine in man; possible clinical implications. Progress in neurobiology, 1986, Volume: 27, Issue:4 Topics: Adenosine; Cardiovascular Diseases; Cardiovascular System; Humans; Hypoxia; Ischemia; Purines; Recep	1986
Aminophylline toxicity. Pediatric clinics of North America, 1987, Volume: 34, Issue:1 Topics: Adolescent; Aminophylline; Cardiovascular Diseases; Child; Gastrointestinal Diseases; Humans; Kineti	1987
[Recent data on coronary dilators]. Actualites pharmacologiques, 1968, Volume: 21 Topics: Amino Alcohols; Aminophylline; Animals; Benzofurans; Cardiovascular Diseases; Cats; Coronary Disease	1968

Article	Year
The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. Chest, 2007, Volume: 132, Issue:3 Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Biomarkers; C-Reactive Protein; Cardiovascular Disea	2007
Dose-dependency of caffeine metabolism with repeated dosing. Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:3 Topics: Adult; Caffeine; Cardiovascular Diseases; Coffee; Dose-Response Relationship, Drug; Female; Humans;	1990

Article	Year
Risk for death associated with medications for recently diagnosed chronic obstructive pulmonary disease. Annals of internal medicine, 2008, Sep-16, Volume: 149, Issue:6 Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aged; Aged, 80 and ov	2008
Risk for death associated with medications for recently diagnosed chronic obstructive pulmonary disease. Annals of internal medicine, 2008, Sep-16, Volume: 149, Issue:6 Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aged; Aged, 80 and ov	2008
Risk for death associated with medications for recently diagnosed chronic obstructive pulmonary disease. Annals of internal medicine, 2008, Sep-16, Volume: 149, Issue:6 Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aged; Aged, 80 and ov	2008
Risk for death associated with medications for recently diagnosed chronic obstructive pulmonary disease. Annals of internal medicine, 2008, Sep-16, Volume: 149, Issue:6 Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aged; Aged, 80 and ov	2008
Praxinor: abuse and dependence. Prescrire international, 2009, Volume: 18, Issue:99 Topics: Cardiovascular Diseases; Drug Combinations; Humans; Hypotension, Orthostatic; Substance-Related Diso	2009
Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers. Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:7 Topics: Adolescent; Adult; Caffeine; Cardiovascular Diseases; Cytochrome P-450 CYP1A2; Enzyme Activation; Hu	2009
[Results with bilophyllin]. Der Praktische Arzt, 1952, Jan-15, Volume: 6, Issue:56 Topics: Bile Acids and Salts; Cardiovascular Diseases; Salts; Theophylline	1952
[Effect of 1,3-dimethylxanthine ethylendiamine on gastric secretion of hydrochloric acid in heart diseases]. Folia cardiologica, 1952, Volume: 11, Issue:6 Topics: Aminophylline; Cardiovascular Diseases; Gastric Juice; Heart Diseases; Hydrochloric Acid; Metabolic	1952
[Clinical and oscillographic studies on the activity of a new watersoluble theophylline derivative, DHT]. Deutsche medizinische Wochenschrift (1946), 1953, Jan-02, Volume: 78, Issue:1 Topics: Cardiovascular Diseases; Theophylline	1953
[Effect of theophylline preparation on blood circulation]. Medizinische Klinik, 1953, Oct-09, Volume: 48, Issue:41 Topics: Cardiovascular Diseases; Humans; Theophylline	1953
The use of buthoids (butaphyllamine suppositories) as adjuncts in the treatment of cardiovascular disease. The Ohio State medical journal, 1953, Volume: 49, Issue:10 Topics: Cardiovascular Diseases; Pessaries; Suppositories; Theophylline	1953
[Therapy of cardiovascular disorders and hypertension with a new purine derivative]. Deutsche medizinische Wochenschrift (1946), 1953, Nov-06, Volume: 78, Issue:45 Topics: Cardiovascular Diseases; Humans; Hypertension; Purines; Theophylline	1953
[Experiences in the clinical application of oxyethyltheophylline (cordalin)]. Medizinische Klinik, 1953, Nov-20, Volume: 48, Issue:47 Topics: Cardiovascular Diseases; Humans; Theophylline	1953
[Study and experience report of aerosol therapy with theophylline derivatives]. Munchener medizinische Wochenschrift (1950), 1954, Oct-15, Volume: 96, Issue:42 Topics: Aerosols; Bronchi; Bronchial Diseases; Cardiovascular Diseases; Disease; Heart Diseases; Theophyllin	1954
[The mode of action and clinical significance of theophylline]. Munchener medizinische Wochenschrift (1950), 1954, Nov-12, Volume: 96, Issue:46 Topics: Cardiovascular Diseases; Kidney; Theophylline	1954
[The diuretic effects oxyethyl-theophylline]. Munchener medizinische Wochenschrift (1950), 1954, Apr-02, Volume: 96, Issue:14 Topics: Cardiovascular Diseases; Diuretics; Theophylline	1954
[On the treatment of acute cerebral and cardiac blood circulation disorders]. Munchener medizinische Wochenschrift (1950), 1955, Aug-19, Volume: 97, Issue:33 Topics: Brain; Cardiac Glycosides; Cardiovascular Diseases; Heart; Humans; Hypoxia; Theophylline	1955
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[Clinicotherapeutic research on a new synthetic theophylline derivative]. Minerva medica, 1956, Oct-24, Volume: 47, Issue:85 Topics: Asthma; Cardiovascular Diseases; Humans; Research; Theophylline	1956
[Clinicotherapeutic research on a new synthetic theophylline derivative]. Minerva medica, 1956, Oct-24, Volume: 47, Issue:85 Topics: Asthma; Cardiovascular Diseases; Humans; Research; Theophylline	1956
[Clinicotherapeutic research on a new synthetic theophylline derivative]. Minerva medica, 1956, Oct-24, Volume: 47, Issue:85 Topics: Asthma; Cardiovascular Diseases; Humans; Research; Theophylline	1956
[Clinical experiences with the new vasodilator permanil]. Munchener medizinische Wochenschrift (1950), 1957, Jul-12, Volume: 99, Issue:28 Topics: Adenosine; Cardiovascular Diseases; Theophylline; Tissue Extracts; Vasodilator Agents	1957
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[Therapeutic activity of choline theophyllinate associated with papaverine trichlorohydroxyethyl-p-aminobenzoate]. Minerva medica, 1958, Mar-07, Volume: 49, Issue:19 Topics: Cardiovascular Diseases; Choline; Humans; Papaverine; para-Aminobenzoates; Theophylline	1958
[New medicinal treatment possibilities of angiopathy in diabetics with 3-(methyloxyethylamino)-2-oxyprophyltheophylline nicotinate (complamin)]. Munchener medizinische Wochenschrift (1950), 1958, Dec-26, Volume: 100, Issue:52 Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Niacin; Nicotinic Acids; Theophy	1958
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theophylline and Cardiovascular Diseases