Page last updated: 2024-10-22

theophylline and Cacosmia

theophylline has been researched along with Cacosmia in 10 studies

Research Excerpts

Excerpt	Relevance	Reference
"Theophylline, used in the treatment for various pulmonary pathologies, is usually given orally with drug levels measured primarily in blood serum and occasionally in saliva."	2.77	Comparative monitoring of oral theophylline treatment in blood serum, saliva, and nasal mucus. ( Henkin, RI, 2012)
"Oral theophylline treatment improved taste and smell acuity in 6 patients after 2 to 12 months of treatment."	2.77	Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. ( Henkin, RI; Minnick-Poppe, L; Schultz, M, 2012)
"Theophylline was effective in improving smell function in patients with smell loss."	2.74	An open-label controlled trial of theophylline for treatment of patients with hyposmia. ( Henkin, RI; Schmidt, L; Velicu, I, 2009)

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (10.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (20.00)	29.6817
2010's	5 (50.00)	24.3611
2020's	2 (20.00)	2.80

Authors

Authors	Studies
Lee, JJ	2
Gupta, S	2
Kallogjeri, D	2
Piccirillo, JF	2
Perrin, A	1
Khan, A	1
Smith, HJ	1
Farrell, N	1
Nigwekar, SU	1
Weiser, JM	1
Kalim, S	1
Xu, D	1
Wibecan, JL	1
Dougherty, SM	1
Mercier-Lafond, L	1
Corapi, KM	1
Eneanya, ND	1
Holbrook, EH	1
Brown, D	1
Thadhani, RI	1
Păunescu, TG	1
Henkin, RI	5
Velicu, I	2
Schmidt, L	2
Gudziol, V	1
Pietsch, J	1
Witt, M	1
Hummel, T	1
Schultz, M	1
Minnick-Poppe, L	1
Toth, J	1
Temmel, AF	1

Clinical Trials (5)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Smell in Covid-19 and Efficacy of Nasal Theophylline[NCT04789499]	Phase 2	51 participants (Actual)	Interventional	2021-03-15	Completed
Smell in COVID-19 and Efficacy of Nasal Theophylline 3[NCT05947643]	Phase 2	240 participants (Anticipated)	Interventional	2022-11-22	Recruiting
Helping Olfaction and Nutrition On Renal Replacement[NCT02479451]	Phase 2	12 participants (Actual)	Interventional	2015-10-31	Completed
A Randomized, Double-Blinded, Placebo-Controlled Trial to Determine The Safety and Efficacy of CYR-064[NCT06019000]	Phase 2	150 participants (Anticipated)	Interventional	2023-09-26	Recruiting
Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia (FluCOP Trial)[NCT05216614]	Phase 2	0 participants (Actual)	Interventional	2021-12-14	Withdrawn (stopped due to Unable to obtain investigational product)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

36-Item Short Form Health Survey (SF-36)

The SF-36 is a well-established 36-item questionnaire evaluating physical functioning, bodily pain, role limitations due to physical health problems, role limitations due to personal or emotional problems, emotional well-being, social functioning, energy/fatigue, and general health perceptions. This test allows us to study the overall quality of life for those suffering from COVID-19 related OD. There is no single overall score for SF-36. The SF 36 generates 8 subscales with scores ranging from 0 (worst) to 100 (best). General health domain scores are reported here. (NCT04789499)
Timeframe: Baseline assessment

Intervention	score on a scale (Median)
Theophylline	75
Placebo	80

Change in Questionnaire for Olfactory Dysfunction (QOD) From Baseline to 6 Weeks Post Intervention

Questionnaire for Olfactory Dysfunction (QOD) assesses health-related quality of life of participants based on four factors such as eating, mental health, social interactions, or fear of dysfunction.. The survey also includes questions on parosmia, a phenomena of COVID-related OD. The QOD consists of 17 statements that participants score from 0-3, resulting in a total score from 0 to 51. Higher scores reflect better olfactory-specific QOL. (NCT04789499)
Timeframe: Comparison at 6 weeks post-intervention from baseline

Intervention	score on a scale (Median)
Theophylline	0.86
Placebo	1.43

Olfactory Dysfunction Outcomes Rating (ODOR)

The ODOR is a 28-item QOL instrument with a total score ranging from 0 to 112 points. Higher scores indicate worse QOL with higher degree of dysfunction and limitation. A decrease of 15 or more points is deemed to be a clinically significant improvement in QOL. (NCT04789499)
Timeframe: Comparison of response rate at 6 weeks post-intervention from baseline between the 2 study groups

Intervention	score on a scale (Median)
Theophylline	-6.5
Placebo	-4.5

University of Pennsylvania Smell Identification Test (UPSIT)

"UPSIT 0-40 with higher scores indicating better smell.~This test is an objective, clinically validated 40-question forced-choice odor identification test where microencapsulated odorants on a strip are released by scratching. Out of a total of 40 points, normosmia is defined as ≥34 for males and ≥35 for females, and an increase in ≥4 points will be deemed a clinically significant improvement in symptoms." (NCT04789499)
Timeframe: Comparison at 6 weeks post-intervention from baseline

Intervention	score on a scale (Median)
Theophylline	3
Placebo	0

UPSIT

"UPSIT 0-40 with higher scores indicating better results.~The response rate defined as the number of participants in each group self-reporting of at least slightly better improvement in the Clinical Global Improvement Scale at 6 weeks post intervention as compared to baseline, devided by the total number of participants in that specific group. The CGI-Improvement Scale has seven response options (from 1 as Very Much Improved to 7 as Very Much Worsened) for answers to the question Compared to your sense of smell before you started the nasal irrigations, how would you rate your sense of smell now . Participants reporting 3 as Minimally Improved, 2 as Much Improved, or 1 as Very Much Improved in the CGI-I will be deemed responders to treatment, and the rate of responders will be compared between the two arms." (NCT04789499)
Timeframe: Comparison of response rate at 6 weeks post-intervention from baseline between the 2 study groups

Intervention	percentage of participants (Number)
Theophylline	59
Placebo	43

Reviews

1 review available for theophylline and Cacosmia

Article	Year
[Drug therapy for disturbances of smelling]. Laryngo- rhino- otologie, 2004, Volume: 83, Issue:2 Topics: Adrenal Cortex Hormones; Controlled Clinical Trials as Topic; Dopamine; Humans; Olfaction Disorders;	2004

Trials

5 trials available for theophylline and Cacosmia

Article	Year
Safety of High-Dose Nasal Theophylline Irrigation in the Treatment of Postviral Olfactory Dysfunction: A Dose-Escalation Study. JAMA otolaryngology-- head & neck surgery, 2022, 09-01, Volume: 148, Issue:9 Topics: Humans; Nasal Lavage; Olfaction Disorders; Smell; Theophylline	2022
Safety of High-Dose Nasal Theophylline Irrigation in the Treatment of Postviral Olfactory Dysfunction: A Dose-Escalation Study. JAMA otolaryngology-- head & neck surgery, 2022, 09-01, Volume: 148, Issue:9 Topics: Humans; Nasal Lavage; Olfaction Disorders; Smell; Theophylline	2022
Safety of High-Dose Nasal Theophylline Irrigation in the Treatment of Postviral Olfactory Dysfunction: A Dose-Escalation Study. JAMA otolaryngology-- head & neck surgery, 2022, 09-01, Volume: 148, Issue:9 Topics: Humans; Nasal Lavage; Olfaction Disorders; Smell; Theophylline	2022
Safety of High-Dose Nasal Theophylline Irrigation in the Treatment of Postviral Olfactory Dysfunction: A Dose-Escalation Study. JAMA otolaryngology-- head & neck surgery, 2022, 09-01, Volume: 148, Issue:9 Topics: Humans; Nasal Lavage; Olfaction Disorders; Smell; Theophylline	2022
Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19-Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial. JAMA otolaryngology-- head & neck surgery, 2022, 09-01, Volume: 148, Issue:9 Topics: Adult; COVID-19; Double-Blind Method; Female; Humans; Male; Middle Aged; Nasal Lavage; Olfaction Dis	2022
Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19-Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial. JAMA otolaryngology-- head & neck surgery, 2022, 09-01, Volume: 148, Issue:9 Topics: Adult; COVID-19; Double-Blind Method; Female; Humans; Male; Middle Aged; Nasal Lavage; Olfaction Dis	2022
Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19-Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial. JAMA otolaryngology-- head & neck surgery, 2022, 09-01, Volume: 148, Issue:9 Topics: Adult; COVID-19; Double-Blind Method; Female; Humans; Male; Middle Aged; Nasal Lavage; Olfaction Dis	2022
Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19-Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial. JAMA otolaryngology-- head & neck surgery, 2022, 09-01, Volume: 148, Issue:9 Topics: Adult; COVID-19; Double-Blind Method; Female; Humans; Male; Middle Aged; Nasal Lavage; Olfaction Dis	2022
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
An open-label controlled trial of theophylline for treatment of patients with hyposmia. The American journal of the medical sciences, 2009, Volume: 337, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Middle Aged; Olfaction Disorders;	2009
Comparative monitoring of oral theophylline treatment in blood serum, saliva, and nasal mucus. Therapeutic drug monitoring, 2012, Volume: 34, Issue:2 Topics: Administration, Oral; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Drug Monitoring; Fe	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study. Archives of otolaryngology--head & neck surgery, 2012, Volume: 138, Issue:11 Topics: Administration, Intranasal; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Dru	2012

Other Studies

4 other studies available for theophylline and Cacosmia

Article	Year
Characterization and Correction of Olfactory Deficits in Kidney Disease. Journal of the American Society of Nephrology : JASN, 2017, Volume: 28, Issue:11 Topics: Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Olfaction Disorders; Phosphodiesterase I	2017
Theophylline induces changes in the electro-olfactogram of the mouse. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2010, Volume: 267, Issue:2 Topics: Administration, Intranasal; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; E	2010
Relative resistance to oral theophylline treatment in patients with hyposmia manifested by decreased secretion of nasal mucus cyclic nucleotides. The American journal of the medical sciences, 2011, Volume: 341, Issue:1 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cyclic AMP; Cyclic GMP; Female; Humans; Male;	2011
Disordered smell. Lancet (London, England), 1988, Oct-15, Volume: 2, Issue:8616 Topics: Humans; Olfaction Disorders; Theophylline	1988