theophylline has been researched along with Brain Ischemia in 29 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative mean transit time (rMTT) in the infarct core, penumbra, and unaffected tissue were measured using multi-parametric MRI at baseline and 3‑h follow-up in patients treated with theophylline or placebo as an add-on to thrombolytic therapy." | 9.51 | Perfusion Changes in Acute Stroke Treated with Theophylline as an Add-on to Thrombolysis : A Randomized Clinical Trial Subgroup Analysis. ( Andersen, G; Fiehler, J; Forkert, ND; Hjort, N; Modrau, B; Nygård Johansen, M; Vorum, H; Winder, A, 2022) |
| "The objective of this review was to assess the effect of theophylline and its analogues, aminophylline and caffeine, in people with confirmed or presumed acute ischaemic stroke." | 8.82 | Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke. ( Bath, PM, 2004) |
| "The objective of this review was to assess the effect of theophylline and its analogues (aminophylline and caffeine) in people with confirmed or presumed acute ischaemic stroke." | 8.80 | Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke. ( Bath, FJ; Bath, PM; Mohiuddin, AA, 2000) |
| "The TEA-Stroke trial (The Theophylline in Acute Ischemic Stroke) was an investigator-initiated 2-center, proof-of-concept, phase II clinical study with a randomized, double-blinded, placebo-controlled design." | 7.96 | Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. ( Andersen, G; Bach, FW; Eskildsen, HW; Hansen, MB; Hjort, N; Johansen, MB; Mikkelsen, IK; Modrau, B; Mouridsen, K; Nielsen, A; Povlsen, JP; Yavarian, Y; Østergaard, L, 2020) |
| "The neuroprotective role of endogenous adenosine during forebrain ischemia elicited by 4-vessel occlusion in rats was assessed using the adenosine antagonist, theophylline (32 mg/kg)." | 7.68 | Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia. ( Allix, M; Boulu, RG; Callebert, J; Lekieffre, D; Plotkine, M, 1991) |
| "The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative mean transit time (rMTT) in the infarct core, penumbra, and unaffected tissue were measured using multi-parametric MRI at baseline and 3‑h follow-up in patients treated with theophylline or placebo as an add-on to thrombolytic therapy." | 5.51 | Perfusion Changes in Acute Stroke Treated with Theophylline as an Add-on to Thrombolysis : A Randomized Clinical Trial Subgroup Analysis. ( Andersen, G; Fiehler, J; Forkert, ND; Hjort, N; Modrau, B; Nygård Johansen, M; Vorum, H; Winder, A, 2022) |
| "The objective of this review was to assess the effect of theophylline and its analogues, aminophylline and caffeine, in people with confirmed or presumed acute ischaemic stroke." | 4.82 | Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke. ( Bath, PM, 2004) |
| "The objective of this review was to assess the effect of theophylline and its analogues (aminophylline and caffeine) in people with confirmed or presumed acute ischaemic stroke." | 4.80 | Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke. ( Bath, FJ; Bath, PM; Mohiuddin, AA, 2000) |
| "The TEA-Stroke trial (The Theophylline in Acute Ischemic Stroke) was an investigator-initiated 2-center, proof-of-concept, phase II clinical study with a randomized, double-blinded, placebo-controlled design." | 3.96 | Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial. ( Andersen, G; Bach, FW; Eskildsen, HW; Hansen, MB; Hjort, N; Johansen, MB; Mikkelsen, IK; Modrau, B; Mouridsen, K; Nielsen, A; Povlsen, JP; Yavarian, Y; Østergaard, L, 2020) |
| "5% O2), to topical adenosine (10[-5] and 10[-4] mol/L) and to arterial hypercapnia (inhalation of 5% and 10% CO2 in air) before and after 10 minutes of global ischemia." | 3.70 | Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. ( Bari, F; Busija, DW; Louis, TM, 1998) |
| "The purpose of this study was to determine the effects of adenosine agonists and an antagonist on ischemia-induced extracellular glutamate concentrations in an animal model of transient cerebral ischemia using in vivo cerebral microdialysis." | 3.70 | Effects of adenosine agonists and an antagonist on excitatory transmitter release from the ischemic rabbit hippocampus. ( Martinez-Tica, JF; Zornow, MH, 2000) |
| "The neuroprotective role of endogenous adenosine during forebrain ischemia elicited by 4-vessel occlusion in rats was assessed using the adenosine antagonist, theophylline (32 mg/kg)." | 3.68 | Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia. ( Allix, M; Boulu, RG; Callebert, J; Lekieffre, D; Plotkine, M, 1991) |
| "We investigated the influence of the adenosine antagonist theophylline on the degree of hippocampal cell damage in the Mongolian gerbil following brief periods of forebrain ischemia." | 3.67 | Effect of theophylline on ischemically induced hippocampal damage in Mongolian gerbils: a behavioral and histopathological study. ( Hinze, HJ; Keil, M; Rudolphi, KA, 1987) |
| "Moderate hyperglycemia was achieved by administering 17% D-glucose (3 g/kg i." | 1.29 | Effects of theophylline and cyclohexyladenosine on brain injury following normo- and hyperglycemic ischemia: a histopathologic study in the rat. ( Hsu, SS; Meno, JR; Winn, HR; Zhou, JG, 1994) |
| "Adenosine, which also increases during cerebral ischemia, is proposed to inhibit neurotransmitter release." | 1.28 | Adenosine receptor blockade augments interstitial fluid levels of excitatory amino acids during cerebral ischemia. ( Grabb, MC; Roche, FM; Sciotti, VM; Van Wylen, DG, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (17.24) | 18.7374 |
| 1990's | 13 (44.83) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Colotta, V | 3 |
| Catarzi, D | 3 |
| Varano, F | 3 |
| Capelli, F | 1 |
| Lenzi, O | 3 |
| Filacchioni, G | 3 |
| Martini, C | 3 |
| Trincavelli, L | 3 |
| Ciampi, O | 3 |
| Pugliese, AM | 3 |
| Pedata, F | 4 |
| Schiesaro, A | 1 |
| Morizzo, E | 3 |
| Moro, S | 3 |
| Traini, C | 2 |
| Modrau, B | 2 |
| Andersen, G | 2 |
| Mikkelsen, IK | 1 |
| Nielsen, A | 1 |
| Hansen, MB | 1 |
| Johansen, MB | 1 |
| Eskildsen, HW | 1 |
| Povlsen, JP | 1 |
| Yavarian, Y | 1 |
| Mouridsen, K | 1 |
| Østergaard, L | 1 |
| Bach, FW | 1 |
| Hjort, N | 2 |
| Winder, A | 1 |
| Nygård Johansen, M | 1 |
| Fiehler, J | 1 |
| Vorum, H | 1 |
| Forkert, ND | 1 |
| FAZEKAS, JF | 1 |
| ALMAN, RW | 1 |
| TICKTIN, HE | 1 |
| EHRMANTRAUT, WR | 1 |
| SAVARESE, CJ | 1 |
| Bath, PM | 2 |
| Olsson, T | 1 |
| Cronberg, T | 1 |
| Rytter, A | 1 |
| Asztély, F | 1 |
| Fredholm, BB | 2 |
| Smith, ML | 1 |
| Wieloch, T | 2 |
| Benzi, G | 1 |
| Arrigoni, E | 1 |
| Pastoris, O | 1 |
| Raimondo, S | 1 |
| Dossena, M | 1 |
| Fulle, D | 1 |
| Tumminello, MC | 1 |
| Villa, RF | 1 |
| Kozlova, EN | 1 |
| Nikitin, IuM | 1 |
| Strel'tsova, EN | 1 |
| Zhou, JG | 1 |
| Meno, JR | 2 |
| Hsu, SS | 1 |
| Winn, HR | 2 |
| Heron, A | 1 |
| Lasbennes, F | 1 |
| Seylaz, J | 1 |
| Reshef, A | 1 |
| Sperling, O | 1 |
| Zoref-Shani, E | 1 |
| Bari, F | 2 |
| Louis, TM | 2 |
| Busija, DW | 2 |
| Barth, A | 1 |
| Newell, DW | 1 |
| Nguyen, LB | 1 |
| Wender, R | 1 |
| Janigro, D | 1 |
| Bona, E | 1 |
| Adén, U | 1 |
| Gilland, E | 1 |
| Hagberg, H | 1 |
| Latini, S | 1 |
| Bordoni, F | 1 |
| Corradetti, R | 1 |
| Mohiuddin, AA | 1 |
| Bath, FJ | 1 |
| Martinez-Tica, JF | 1 |
| Zornow, MH | 1 |
| Hiraide, T | 1 |
| Katsura, K | 1 |
| Muramatsu, H | 1 |
| Asano, G | 1 |
| Katayama, Y | 1 |
| Tanaka, E | 1 |
| Yasumoto, S | 1 |
| Hattori, G | 1 |
| Niiyama, S | 1 |
| Matsuyama, S | 1 |
| Higashi, H | 1 |
| Sciotti, VM | 1 |
| Roche, FM | 1 |
| Grabb, MC | 1 |
| Van Wylen, DG | 1 |
| Tominaga, K | 1 |
| Shibata, S | 1 |
| Watanabe, S | 1 |
| Dux, E | 1 |
| Schubert, P | 1 |
| Kreutzberg, GW | 1 |
| Lekieffre, D | 1 |
| Callebert, J | 1 |
| Plotkine, M | 1 |
| Allix, M | 1 |
| Boulu, RG | 1 |
| von Lubitz, DK | 1 |
| Marangos, PJ | 1 |
| Blomqvist, P | 1 |
| Lindvall, O | 1 |
| Stenevi, U | 1 |
| Rudolphi, KA | 1 |
| Keil, M | 1 |
| Hinze, HJ | 1 |
3 reviews available for theophylline and Brain Ischemia
| Article | Year |
|---|---|
CURRENT THERAPEUTIC CONCEPTS OF CEREBRAL AND MYOCARDIAL VASCULAR DISEASE.
Topics: Acetazolamide; Anticoagulants; Brain Ischemia; Cerebrovascular Disorders; Coronary Disease; Histamin | 1964 |
Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke.
Topics: Aminophylline; Brain Ischemia; Caffeine; Humans; Randomized Controlled Trials as Topic; Stroke; Theo | 2004 |
Theophylline, aminophylline, caffeine and analogues for acute ischaemic stroke.
Topics: Aminophylline; Brain Ischemia; Caffeine; Humans; Stroke; Theophylline; Vasodilator Agents | 2000 |
1 trial available for theophylline and Brain Ischemia
| Article | Year |
|---|---|
Perfusion Changes in Acute Stroke Treated with Theophylline as an Add-on to Thrombolysis : A Randomized Clinical Trial Subgroup Analysis.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Humans; Infarction; Magnetic Resonance Imaging | 2022 |
25 other studies available for theophylline and Brain Ischemia
| Article | Year |
|---|---|
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Benzamides; Brain Ischemia; Cerebral Cortex; CHO Cells; | 2007 |
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Topics: Adenosine A3 Receptor Antagonists; Animals; Binding, Competitive; Brain Ischemia; Cattle; Cell Membr | 2008 |
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Topics: Adenosine A3 Receptor Antagonists; Animals; Brain Ischemia; Cattle; Cell Line; Cerebral Cortex; Corp | 2009 |
Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke: A Randomized Placebo-Controlled Trial.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Female; Fibrinolytic Agents; Humans; Ischemia; Male; Middle | 2020 |
Deletion of the adenosine A1 receptor gene does not alter neuronal damage following ischaemia in vivo or in vitro.
Topics: Adenosine A1 Receptor Antagonists; Animals; Brain Ischemia; Excitatory Postsynaptic Potentials; Hipp | 2004 |
Drug interference on some biochemical parameters of rat cerebral cortex during post-ischemic recovery.
Topics: Alanine; Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Dihydroergotoxine; Energy Transfer; | 1980 |
[Use of thermography and ultrasound dopplerography for evaluating efficacy of complamin in the treatment of patients with disorders of cerebral circulation].
Topics: Adult; Brain Ischemia; Cerebrovascular Circulation; Humans; Male; Theophylline; Thermography; Time F | 1981 |
Effects of theophylline and cyclohexyladenosine on brain injury following normo- and hyperglycemic ischemia: a histopathologic study in the rat.
Topics: Adenosine; Animals; Blood Pressure; Brain; Brain Ischemia; Hyperglycemia; Male; Osmolar Concentratio | 1994 |
Adenosine modulation of amino acid release in rat hippocampus during ischemia and veratridine depolarization.
Topics: Adenosine; Amino Acids; Animals; Brain Ischemia; Dialysis; Hippocampus; Infusions, Parenteral; Male; | 1993 |
Preconditioning of primary rat neuronal cultures against ischemic injury: characterization of the "time window of protection'.
Topics: Animals; Brain Ischemia; Cells, Cultured; Iodoacetates; Iodoacetic Acid; Ischemic Preconditioning; L | 1996 |
Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets.
Topics: Animals; Animals, Newborn; Arterioles; Brain Ischemia; Cerebral Arteries; Dizocilpine Maleate; Excit | 1997 |
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Br | 1997 |
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Body Temperature; Body Weight; Brain; | 1997 |
Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets.
Topics: Adenosine; Adenosine Triphosphate; Administration, Topical; Analysis of Variance; Animals; Arteriole | 1998 |
Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices.
Topics: Adenosine; Animals; Brain Ischemia; Extracellular Space; Hippocampus; In Vitro Techniques; Kinetics; | 1999 |
Effects of adenosine agonists and an antagonist on excitatory transmitter release from the ischemic rabbit hippocampus.
Topics: Adenosine; Animals; Brain Ischemia; Chromatography, High Pressure Liquid; Electroencephalography; Ex | 2000 |
Adenosine receptor antagonists cancelled the ischemic tolerance phenomenon in gerbil.
Topics: Animals; Brain Ischemia; Dimethyl Sulfoxide; Free Radical Scavengers; Gerbillinae; Hippocampus; Isch | 2001 |
Mechanisms underlying the depression of evoked fast EPSCs following in vitro ischemia in rat hippocampal CA1 neurons.
Topics: Animals; Brain Ischemia; Calcium; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniqu | 2001 |
Adenosine receptor blockade augments interstitial fluid levels of excitatory amino acids during cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Glutamates; Glutamic Acid; Hypo | 1992 |
A neuroprotective effect of adenosine A1-receptor agonists on ischemia-induced decrease in 2-deoxyglucose uptake in rat hippocampal slices.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Brain Ischemia; Deoxyglucose; Hippocampus; In | 1992 |
Ultrastructural localization of calcium in ischemic hippocampal slices: the influence of adenosine and theophylline.
Topics: Adenosine; Animals; Brain Ischemia; Calcium; Dendrites; Hippocampus; Male; Mitochondria; Organ Cultu | 1992 |
Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia.
Topics: Adenosine; Amino Acids; Animals; Brain Ischemia; Dialysis; Male; Prosencephalon; Psychomotor Perform | 1991 |
Cerebral ischemia in gerbils: postischemic administration of cyclohexyl adenosine and 8-sulfophenyl-theophylline.
Topics: Adenosine; Animals; Blood Pressure; Brain Ischemia; Drug Interactions; Female; Gerbillinae; Theophyl | 1990 |
Cyclic AMP concentrations in rat neocortex and hippocampus during and following incomplete ischemia: effects of central noradrenergic neurons, prostaglandins, and adenosine.
Topics: Adenosine; Animals; Brain Ischemia; Cerebral Cortex; Cyclic AMP; Energy Metabolism; Fatty Acids, Non | 1985 |
Effect of theophylline on ischemically induced hippocampal damage in Mongolian gerbils: a behavioral and histopathological study.
Topics: Adenosine; Animals; Behavior, Animal; Brain Ischemia; Cerebrovascular Circulation; Gerbillinae; Hipp | 1987 |