Page last updated: 2024-10-22

theophylline and Bradycardia

theophylline has been researched along with Bradycardia in 55 studies

Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.

Research Excerpts

ExcerptRelevanceReference
"Apnea of prematurity (AOP) is frequently managed with nasal continuous positive airway pressure (NCPAP)."9.09High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure. ( Hudson-Mason, A; Lemke, RP; Osiovich, H; Sreenan, C, 2001)
" Aminophylline (n = 98) and caffeine citrate (n = 82) were equally effective in preventing apnea and bradycardia."9.08Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates. ( Brendstrup, L; Flachs, H; Larsen, PB; Skov, L, 1995)
"In this study, both acute electrophysiologic actions of intravenously administered theophylline and clinical effects of chronic oral theophylline therapy were assessed in 10 young patients (aged 9 to 41 years) without clinically significant cardiac disease, in whom recurrent symptoms of syncope and dizziness were attributed to transient bradyarrhythmias (sinus pauses, marked sinus bradycardia or paroxysmal atrioventricular [AV] block)."9.05Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. ( Benditt, DG; Benson, DW; Crouse, L; Dunnigan, A; Kreitt, J; Pritzker, MR; Scheinman, MM, 1983)
"Theophylline's use via enteral route can successfully and safely treat SCI-related bradycardia, and may help avoid the long term use of inotropic and chronotropic infusions and pacemakers and their associated risks and complications."7.76Theophylline for bradycardia secondary to cervical spinal cord injury. ( Naydenov, SK; Ponzillo, JJ; Sadaka, F, 2010)
" We have investigated how CHU affects cardiovascular responses evoked by acute systemic hypoxia in adult male offspring, recognising that adenosine contributes to hypoxia-induced muscle vasodilatation and bradycardia by acting on A(1) receptors in normal (N) rats."7.76Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. ( Coney, AM; Marshall, JM, 2010)
"Small-dose theophylline can be a useful alternative in the treatment of bradycardia in patients with spinal cord injury."7.73The use of small-dose theophylline for the treatment of bradycardia in patients with spinal cord injury. ( Schulz-Stübner, S, 2005)
"This is the first case published in the English-language literature describing the use of intravenous theophylline as an alternative therapy to temporary pacing in a patient with sepsis secondary to thermal injury."7.71Intravenous theophylline--an alternative to temporary pacing in the management of bradycardia secondary to AV nodal block. ( Al-Jazairi, AS; Cawley, MJ; Stone, EA, 2001)
"The use of theophylline for posttransplantation bradyarrhythmias increased heart rate and facilitated the withdrawal of chronotropic support."7.69Bradycardia after heart transplantation: reversal with theophylline. ( Belardinelli, L; Bertolet, BD; Conti, JB; Eagle, DA; Mills, RM, 1996)
" Significant complications occurred in 4 of 38 patients, including atrial fibrillation, accelerated ventricular tachycardia, apnea, and 1 minute of asystole."7.69Therapeutic and diagnostic utility of adenosine during tachycardia evaluation in children. ( Crosson, JE; Dunnigan, A; Etheridge, SP; Hesslein, PS; Milstein, S, 1994)
"Primidone represents a possible adjuvant therapy in theophylline-resistant apnea of prematurity."7.68The use of primidone in neonates with theophylline-resistant apnea. ( Gaylord, M; Lorch, V; Miller, CA; Zimmerman, AW, 1993)
"This review provides an understanding of current problems related to apnea of infancy."7.67Infant apnea. ( Fox, WW; Spitzer, AR, 1986)
"The role of adenosine as a mediator of the bradycardia associated with graded global ischaemia in rat heart was examined."7.67Mediation by adenosine of bradycardia in rat heart during graded global ischaemia. ( Headrick, J; Willis, RJ, 1988)
"To the well known methods for prevention of neonatal apnea like stimulation, CPAP, and mechanical ventilation the treatment with theophylline has been added recently."7.66[Prevention of neonatal apnea with theophylline (author's transl)]. ( Frisch, H; Irnberger, E; Müller, W, 1978)
" Despite apnea monitoring systems, 136/203 (67%) apneic episodes greater than or equal to 20 seconds in duration, including 19 episodes greater than or equal to 50 seconds in duration, were not recorded by nursing staff."7.66Undetected episodes of prolonged apnea and severe bradycardia in preterm infants. ( Alexander, JR; Farndon, PA; Jones, RA; Kong, C; Levitt, GA; Richards, JM; Southall, DP; Wilson, AJ, 1983)
"9 micrograms/ml) were observed in seven premature infants with severe idiopathic apnea."7.66Low-dose theophylline therapy in idiopathic apnea of prematurity. ( Auld, PA; Krauss, AN; Milsap, RL; Myers, TF; Reidenberg, MM, 1980)
"The efficacy of theophylline in preventing severe apnea was evaluated in 17 low-birthweight infants (mean weight, 1,400 gm)."7.65Prevention of apnea and bradycardia in low-birthweight infants. ( Gotay, F; Moylan, FM; Rogers, MC; Shannon, DC; Stein, IM; Todres, ID, 1975)
"Several investigators have documented the successful use of oral sustained-release theophylline in treating symptomatic bradycardia and sick sinus syndrome."6.19Effects of theophylline on exercise indices in a patient with chronotropic incompetence. ( Bauch, TD; Dixon, WC, 2000)
"Apnea of prematurity (AOP) is frequently managed with nasal continuous positive airway pressure (NCPAP)."5.09High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure. ( Hudson-Mason, A; Lemke, RP; Osiovich, H; Sreenan, C, 2001)
" Aminophylline (n = 98) and caffeine citrate (n = 82) were equally effective in preventing apnea and bradycardia."5.08Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates. ( Brendstrup, L; Flachs, H; Larsen, PB; Skov, L, 1995)
"In this study, both acute electrophysiologic actions of intravenously administered theophylline and clinical effects of chronic oral theophylline therapy were assessed in 10 young patients (aged 9 to 41 years) without clinically significant cardiac disease, in whom recurrent symptoms of syncope and dizziness were attributed to transient bradyarrhythmias (sinus pauses, marked sinus bradycardia or paroxysmal atrioventricular [AV] block)."5.05Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. ( Benditt, DG; Benson, DW; Crouse, L; Dunnigan, A; Kreitt, J; Pritzker, MR; Scheinman, MM, 1983)
"Theophylline is an important drug for treatment of canine chronic bronchitis and bradyarrhythmias, but new products require validation since pharmacokinetics in dogs can vary by formulation."4.12Pharmacokinetics of a 503B outsourcing facility-produced theophylline in dogs. ( de Oliveira, GAR; Forsythe, L; Li, Z; Reinhart, JM, 2022)
" Theophylline was administered due to postoperative bradycardia."3.80Seizures after heart transplantation--two cases of non-immunosuppressant drug interactions in young patients. ( Baszyńska-Wachowiak, H; Buczkowski, P; Jemielity, M; Pawłowska, M; Perek, B; Straburzyńska-Migaj, E; Urbanowicz, T, 2014)
" We have investigated how CHU affects cardiovascular responses evoked by acute systemic hypoxia in adult male offspring, recognising that adenosine contributes to hypoxia-induced muscle vasodilatation and bradycardia by acting on A(1) receptors in normal (N) rats."3.76Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. ( Coney, AM; Marshall, JM, 2010)
"Theophylline's use via enteral route can successfully and safely treat SCI-related bradycardia, and may help avoid the long term use of inotropic and chronotropic infusions and pacemakers and their associated risks and complications."3.76Theophylline for bradycardia secondary to cervical spinal cord injury. ( Naydenov, SK; Ponzillo, JJ; Sadaka, F, 2010)
"Small-dose theophylline can be a useful alternative in the treatment of bradycardia in patients with spinal cord injury."3.73The use of small-dose theophylline for the treatment of bradycardia in patients with spinal cord injury. ( Schulz-Stübner, S, 2005)
"This is the first case published in the English-language literature describing the use of intravenous theophylline as an alternative therapy to temporary pacing in a patient with sepsis secondary to thermal injury."3.71Intravenous theophylline--an alternative to temporary pacing in the management of bradycardia secondary to AV nodal block. ( Al-Jazairi, AS; Cawley, MJ; Stone, EA, 2001)
"8-Phenyltheophylline abolished hypoxia-induced bradycardia and hypertension and produced a nearly 5-fold greater rise in fetal plasma concentrations of corticotropin and approximately a 3-fold greater increase in plasma cortisol levels."3.70Adenosine modulates corticotropin and cortisol release during hypoxia in fetal sheep. ( Chau, A; Koos, BJ; Rose, JC, 1999)
" Significant complications occurred in 4 of 38 patients, including atrial fibrillation, accelerated ventricular tachycardia, apnea, and 1 minute of asystole."3.69Therapeutic and diagnostic utility of adenosine during tachycardia evaluation in children. ( Crosson, JE; Dunnigan, A; Etheridge, SP; Hesslein, PS; Milstein, S, 1994)
"The use of theophylline for posttransplantation bradyarrhythmias increased heart rate and facilitated the withdrawal of chronotropic support."3.69Bradycardia after heart transplantation: reversal with theophylline. ( Belardinelli, L; Bertolet, BD; Conti, JB; Eagle, DA; Mills, RM, 1996)
"Primidone represents a possible adjuvant therapy in theophylline-resistant apnea of prematurity."3.68The use of primidone in neonates with theophylline-resistant apnea. ( Gaylord, M; Lorch, V; Miller, CA; Zimmerman, AW, 1993)
"The treatment of neonatal apnea and bradycardia with methylated xanthines--theophylline and caffeine--is generally accepted."3.68[Effect of methylxanthines on periodic respiration and acid gastroesophageal reflux in newborn infants]. ( Heimann, G; Koch, G; Skopnik, H, 1990)
"2 x Postnatal age in weeks) + 5) is preferred when intravenous theophylline therapy for apnea and bradycardia or for asthma is initiated."3.68Evaluation of three theophylline dosing equations for use in infants up to one year of age. ( Hogue, SL; Phelps, SJ, 1993)
"The role of adenosine as a mediator of the bradycardia associated with graded global ischaemia in rat heart was examined."3.67Mediation by adenosine of bradycardia in rat heart during graded global ischaemia. ( Headrick, J; Willis, RJ, 1988)
"This review provides an understanding of current problems related to apnea of infancy."3.67Infant apnea. ( Fox, WW; Spitzer, AR, 1986)
"9 micrograms/ml) were observed in seven premature infants with severe idiopathic apnea."3.66Low-dose theophylline therapy in idiopathic apnea of prematurity. ( Auld, PA; Krauss, AN; Milsap, RL; Myers, TF; Reidenberg, MM, 1980)
" Despite apnea monitoring systems, 136/203 (67%) apneic episodes greater than or equal to 20 seconds in duration, including 19 episodes greater than or equal to 50 seconds in duration, were not recorded by nursing staff."3.66Undetected episodes of prolonged apnea and severe bradycardia in preterm infants. ( Alexander, JR; Farndon, PA; Jones, RA; Kong, C; Levitt, GA; Richards, JM; Southall, DP; Wilson, AJ, 1983)
"To the well known methods for prevention of neonatal apnea like stimulation, CPAP, and mechanical ventilation the treatment with theophylline has been added recently."3.66[Prevention of neonatal apnea with theophylline (author's transl)]. ( Frisch, H; Irnberger, E; Müller, W, 1978)
"The efficacy of theophylline in preventing severe apnea was evaluated in 17 low-birthweight infants (mean weight, 1,400 gm)."3.65Prevention of apnea and bradycardia in low-birthweight infants. ( Gotay, F; Moylan, FM; Rogers, MC; Shannon, DC; Stein, IM; Todres, ID, 1975)
"If cardiac syncope is unlikely, reflex (neurally mediated) syncope and orthostatic hypotension are the most frequent causes of transient loss of consciousness."2.72New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope. ( Brignole, M; Rivasi, G, 2021)
"He was subsequently diagnosed with sleep apnea associated with frequent and significant sinus pauses."1.42Sleep apnea and severe bradyarrhythmia--an alternative treatment option: a case report. ( Ahmed, W; Al-Faifi, SM; Alsheikh-Ali, AA; Asrar, F; Daoulah, A; Lotfi, A; Ocheltree, S, 2015)

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-199018 (32.73)18.7374
1990's17 (30.91)18.2507
2000's6 (10.91)29.6817
2010's10 (18.18)24.3611
2020's4 (7.27)2.80

Authors

AuthorsStudies
Reinhart, JM1
de Oliveira, GAR1
Forsythe, L1
Li, Z1
Perrine, JA1
Barber, J1
McKnight, RL1
Rowe, AS1
Dahiya, A1
Sharma, R1
Singh, A1
Joshi, P1
Wardhan, H1
Brignole, M2
Rivasi, G1
Kirchertz, R1
Hilbert, T1
Joyce, W1
Wang, T1
Lou, Q1
Hansen, BJ1
Fedorenko, O1
Csepe, TA1
Kalyanasundaram, A1
Li, N1
Hage, LT1
Glukhov, AV1
Billman, GE1
Weiss, R1
Mohler, PJ1
Györke, S1
Biesiadecki, BJ1
Carnes, CA1
Fedorov, VV1
Urbanowicz, T1
Pawłowska, M1
Buczkowski, P1
Perek, B1
Baszyńska-Wachowiak, H1
Straburzyńska-Migaj, E1
Jemielity, M1
Daoulah, A1
Ocheltree, S1
Al-Faifi, SM1
Ahmed, W1
Alsheikh-Ali, AA1
Asrar, F1
Lotfi, A1
La Rocca, R1
Campedel, F1
Materia, V1
Saggese, MP1
Patanè, S1
Koseoglu, Z1
Kara, B1
Satar, S1
Sadaka, F1
Naydenov, SK1
Ponzillo, JJ1
Coney, AM1
Marshall, JM1
Henderson-Smart, DJ1
De Paoli, AG1
Joosen, MJ1
Bueters, TJ1
van Helden, HP1
Schulz-Stübner, S1
Sakamoto, T1
Sadanaga, T1
Okazaki, T1
Haley, TJ1
Benditt, DG1
Benson, DW1
Kreitt, J1
Dunnigan, A2
Pritzker, MR1
Crouse, L1
Scheinman, MM1
Southall, DP1
Levitt, GA1
Richards, JM1
Jones, RA1
Kong, C1
Farndon, PA1
Alexander, JR1
Wilson, AJ1
Carroll, W1
Stempel, D1
Lewiston, NJ1
Milsap, RL2
Krauss, AN2
Auld, PA2
Myers, TF1
Reidenberg, MM1
Larsen, PB1
Brendstrup, L1
Skov, L1
Flachs, H1
Bertolet, BD2
Belardinelli, L2
Kerensky, R1
Hill, JA1
Crosson, JE1
Etheridge, SP1
Milstein, S1
Hesslein, PS1
Hogue, SL1
Phelps, SJ1
Miller, CA1
Gaylord, M1
Lorch, V1
Zimmerman, AW1
Sra, JS1
Jazayeri, MR1
Avitall, B1
Dhala, A1
Deshpande, S1
Blanck, Z1
Akhtar, M1
Grubb, BP1
Kosinski, D1
Mouhaffel, A1
Pothoulakis, A1
Eagle, DA1
Conti, JB1
Mills, RM1
Heinz, G1
du Preez, MJ1
Botha, JH1
McFadyen, ML1
Adhikari, M1
Alboni, P2
Menozzi, C1
Scarfò, S1
Chau, A1
Rose, JC1
Koos, BJ1
Dixon, WC1
Bauch, TD1
Cawley, MJ1
Al-Jazairi, AS1
Stone, EA1
Sreenan, C1
Lemke, RP1
Hudson-Mason, A1
Osiovich, H1
Shannon, DC1
Gotay, F1
Stein, IM1
Rogers, MC1
Todres, ID1
Moylan, FM1
Erkan, NV1
Robinson, H1
Roop, C1
Gal, P2
Frisch, H1
Müller, W1
Irnberger, E1
Prosinska-Kibler, M1
Lucey, JF1
Kragie, L1
Sekovski, B1
Nelson, SD1
Stanley, M1
Love, CJ1
Coyne, KS1
Schaal, SF1
Upton, CJ1
Milner, AD1
Stokes, GM1
Rossi, P1
Ratto, B1
Pedroni, P1
Gatto, E1
Antonioli, GE1
Skopnik, H1
Koch, G1
Heimann, G1
Fuglsang, G1
Nielsen, K1
Kjaer Nielsen, L1
Sennels, F1
Jakobsen, P1
Thelle, T1
Headrick, J1
Willis, RJ1
Spitzer, AR1
Fox, WW1
Boer, HR1
Schaumann, W1
Juhran, W1
Dietmann, K1
Hammer, O1
Kettermann, W1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessment of the Mechanism of Non-cardiac Syncope by 24-hour Ambulatory Blood Pressure Monitoring (ABPM) and Tilt-table Short Cardiovascular Autonomic Function Battery (SCAFB)[NCT05728255]275 participants (Anticipated)Observational2023-04-30Not yet recruiting
Comparison of Humidified High Flow Nasal Cannula to Nasal Continuous Positive Airway Pressure for Non-Invasive Respiratory Support in Neonates[NCT00609882]420 participants (Actual)Interventional2007-12-31Completed
Adaptive Dynamic Inspiratory Nasal Apparatus (ADINA): Comparison to High Flow Nasal Cannula (HFNC)[NCT03171129]40 participants (Anticipated)Interventional2024-01-31Not yet recruiting
High Flow Nasal Cannula vs Bubble Nasal CPAP for the Treatment of Transient Tachypnea of the Newborn in Infants ≥ 35 Weeks Gestation[NCT01270581]7 participants (Actual)Interventional2010-07-31Terminated (stopped due to lack of sufficient enrollment)
Post-extubation High-flow Nasal Oxygen vs. Conventional Oxygen in Patients Recovered From Acute Hypoxemic Respiratory Failure for Preventing Extubation Failure[NCT03361683]127 participants (Actual)Interventional2017-10-01Completed
Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen (O2) as a Treatment for Obstructive Sleep Apnea (OSA) in Infants[NCT02858154]9 participants (Actual)Interventional2016-02-29Completed
Observational, Cross-over Study of the Positive Distending Pressure Generated by Humidified High Flow Nasal Cannula as Compared to Nasal Continuous Positive Airway Pressure[NCT00356668]Phase 316 participants (Actual)Interventional2006-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

AHI From Diagnostic Sleep Study Compared to AHI From Sleep Study Improvement in OSA With Low Flow Oxygen Via Nasal Cannula

All subjects will receive 3-4 hours of experimental treatment (HFNC) during a research portion of a PSG and then for the 6-8 hours of clinically ordered PSG will receive low flow oxygen by nasal cannula. (NCT02858154)
Timeframe: end of visit (12 hours)

Interventionevents/hour (Mean)
AHI from diagnostic sleep studyAHI from improvement in OSA with low flow oxygen by nasal cannula
Average AHI Diagnostic Study Compared to Average AHI With Improvement in OSA With Low Flow Oxygen13.444.9

Average AHI Diagnostic Sleep Study Compared to Average AHI With Improvement in OSA With HFNC

AHI will be compared from diagnostic sleep study to average AHI with improvement in OSA with HFNC (NCT02858154)
Timeframe: End of visit (12 hours)

Interventionevents/hour (Mean)
AHI on diagnostic studyAHI with improvement in OSA with HFNC
Average AHI Diagnostic Sleep Study Compared to Average AHI With Improvement in OSA With HFNC15.65.12

Reviews

6 reviews available for theophylline and Bradycardia

ArticleYear
New insights in diagnostics and therapies in syncope: a novel approach to non-cardiac syncope.
    Heart (British Cardiac Society), 2021, Volume: 107, Issue:11

    Topics: Accidental Falls; Adenosine; Antihypertensive Agents; Atomoxetine Hydrochloride; Atrioventricular No

2021
Prophylactic methylxanthine for prevention of apnoea in preterm infants.
    The Cochrane database of systematic reviews, 2010, Dec-08, Issue:12

    Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Humans; Hypoxia; Infant, Newborn; I

2010
Metabolism and pharmacokinetics of theophylline in human neonates, children, and adults.
    Drug metabolism reviews, 1983, Volume: 14, Issue:2

    Topics: Adult; Age Factors; Apnea; Asthma; Biotransformation; Bradycardia; Caffeine; Child; Female; Half-Lif

1983
Is sinus bradycardia a factor facilitating overt heart failure?
    European heart journal, 1999, Volume: 20, Issue:4

    Topics: Age Distribution; Aged; Aged, 80 and over; Bradycardia; Female; Heart Failure; Humans; Incidence; Ma

1999
Effects of theophylline on exercise indices in a patient with chronotropic incompetence.
    Clinical cardiology, 2000, Volume: 23, Issue:10

    Topics: Bradycardia; Delayed-Action Preparations; Exercise Tolerance; Heart Rate; Humans; Male; Middle Aged;

2000
Theophylline--an alternative therapy for bradyarrhythmia in the elderly.
    Pharmacotherapy, 1992, Volume: 12, Issue:4

    Topics: Aged; Aged, 80 and over; Bradycardia; Electrocardiography; Female; Heart Rate; Hospitals, General; H

1992

Trials

5 trials available for theophylline and Bradycardia

ArticleYear
Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias.
    The American journal of cardiology, 1983, Dec-01, Volume: 52, Issue:10

    Topics: Adolescent; Adult; Atrioventricular Node; Bradycardia; Cardiac Pacing, Artificial; Clinical Trials a

1983
Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature neonates.
    Acta paediatrica (Oslo, Norway : 1992), 1995, Volume: 84, Issue:4

    Topics: Apnea; Bradycardia; Caffeine; Citrates; Drug Combinations; Humans; Infant, Newborn; Infant, Prematur

1995
Effects of theophylline on exercise indices in a patient with chronotropic incompetence.
    Clinical cardiology, 2000, Volume: 23, Issue:10

    Topics: Bradycardia; Delayed-Action Preparations; Exercise Tolerance; Heart Rate; Humans; Male; Middle Aged;

2000
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.
    Pediatrics, 2001, Volume: 107, Issue:5

    Topics: Apnea; Bradycardia; Bronchodilator Agents; Cross-Over Studies; Humans; Infant, Newborn; Infant, Prem

2001
The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants.
    Acta paediatrica Scandinavica, 1989, Volume: 78, Issue:5

    Topics: Administration, Oral; Apnea; Bradycardia; Caffeine; Clinical Trials as Topic; Double-Blind Method; F

1989

Other Studies

45 other studies available for theophylline and Bradycardia

ArticleYear
Pharmacokinetics of a 503B outsourcing facility-produced theophylline in dogs.
    PloS one, 2022, Volume: 17, Issue:1

    Topics: Aminophylline; Animals; Biological Availability; Bradycardia; Bronchitis, Chronic; Cross-Over Studie

2022
Theophylline for Spinal Cord Injury Associated Bradycardia.
    Journal of pharmacy practice, 2023, Volume: 36, Issue:3

    Topics: Bradycardia; Humans; Retrospective Studies; Spinal Cord Injuries; Theophylline; Vasoconstrictor Agen

2023
Role of Etophylline and Theophylline Prolonged Release Tablet in COVID-19 Associated Sinus Node Dysfunction.
    The Journal of the Association of Physicians of India, 2022, Volume: 70, Issue:1

    Topics: Bradycardia; COVID-19; Humans; Pandemics; SARS-CoV-2; Sick Sinus Syndrome; Tablets; Theophylline

2022
A week of slow hearts: anaesthesia for eye surgery and shortage of glycopyrrolate.
    Minerva anestesiologica, 2019, Volume: 85, Issue:9

    Topics: Aged; Atropine; Bradycardia; Cholinergic Antagonists; Drug Combinations; Female; Germany; Glycopyrro

2019
Adenosinergic regulation of the cardiovascular system in the red-eared slider Trachemys scripta.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2014, Volume: 174

    Topics: Adenosine; Animals; Bradycardia; Cardiovascular System; Heart Rate; Hemodynamics; Pulmonary Circulat

2014
Upregulation of adenosine A1 receptors facilitates sinoatrial node dysfunction in chronic canine heart failure by exacerbating nodal conduction abnormalities revealed by novel dual-sided intramural optical mapping.
    Circulation, 2014, Jul-22, Volume: 130, Issue:4

    Topics: Action Potentials; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Atrial Fibrillation; Brady

2014
Seizures after heart transplantation--two cases of non-immunosuppressant drug interactions in young patients.
    Annals of transplantation, 2014, Aug-22, Volume: 19

    Topics: Adult; Antiemetics; Bradycardia; Brain; Dopamine D2 Receptor Antagonists; Drug Interactions; Epileps

2014
Sleep apnea and severe bradyarrhythmia--an alternative treatment option: a case report.
    Journal of medical case reports, 2015, May-15, Volume: 9

    Topics: Bradycardia; Humans; Male; Middle Aged; Obesity; Polysomnography; Sleep Apnea Syndromes; Theophyllin

2015
Theophylline and syncope.
    International journal of cardiology, 2016, Nov-15, Volume: 223

    Topics: Adult; Atrioventricular Block; Bradycardia; Electrocardiography; Heart Rate; Humans; Male; Purinergi

2016
Bradycardia and hypotension in mianserin intoxication.
    Human & experimental toxicology, 2010, Volume: 29, Issue:10

    Topics: Adult; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Atropine; Bradycardia; Fema

2010
Theophylline for bradycardia secondary to cervical spinal cord injury.
    Neurocritical care, 2010, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Bradycardia; Critical Care; Humans; Male; Middle Aged; Purinergic P1 Receptor Ant

2010
Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors.
    The Journal of physiology, 2010, Dec-15, Volume: 588, Issue:Pt 24

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Bradycardia; Endothelium, Vascular; Female; H

2010
Cardiovascular effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) decisive for its therapeutic efficacy in sarin poisoning.
    Archives of toxicology, 2004, Volume: 78, Issue:1

    Topics: Adenosine; Animals; Bradycardia; Chemical Warfare Agents; Dose-Response Relationship, Drug; Drug Ant

2004
The use of small-dose theophylline for the treatment of bradycardia in patients with spinal cord injury.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Bradycardia; Cyclic Nucleotide Phosphodiesterases, Type

2005
Sequential use of aminophylline and theophylline for the treatment of atropine-resistant bradycardia after spinal cord injury: a case report.
    Journal of cardiology, 2007, Volume: 49, Issue:2

    Topics: Administration, Oral; Aged; Aminophylline; Atropine; Bradycardia; Cardiotonic Agents; Drug Administr

2007
Undetected episodes of prolonged apnea and severe bradycardia in preterm infants.
    Pediatrics, 1983, Volume: 72, Issue:4

    Topics: Aminophylline; Apnea; Bradycardia; Electrocardiography; Female; Heart Rate; Humans; Infant; Infant,

1983
Sleeping bradycardia during recovery from childhood status asthmaticus.
    Annals of allergy, 1981, Volume: 46, Issue:5

    Topics: Aminophylline; Asthma; Bradycardia; Child; Electrocardiography; Heart Rate; Humans; Isoetharine; Iso

1981
Efficacy of low-dose theophylline.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Apnea; Bradycardia; Heart Rate; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Prematur

1981
Low-dose theophylline therapy in idiopathic apnea of prematurity.
    The Journal of pediatrics, 1980, Volume: 96, Issue:1

    Topics: Apnea; Bradycardia; Carbon Dioxide; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infa

1980
Adenosine blockade as primary therapy for ischemia-induced accelerated idioventricular rhythm: rationale and potential clinical application.
    American heart journal, 1994, Volume: 128, Issue:1

    Topics: Adenosine; Aged; Arrhythmia, Sinus; Bradycardia; Female; Humans; Male; Myocardial Ischemia; Streptok

1994
Therapeutic and diagnostic utility of adenosine during tachycardia evaluation in children.
    The American journal of cardiology, 1994, Jul-15, Volume: 74, Issue:2

    Topics: Adenosine; Adolescent; Adult; Apnea; Arrhythmia, Sinus; Atrial Fibrillation; Atrial Function; Atriov

1994
Evaluation of three theophylline dosing equations for use in infants up to one year of age.
    The Journal of pediatrics, 1993, Volume: 123, Issue:4

    Topics: Apnea; Asthma; Bradycardia; Dose-Response Relationship, Drug; Female; Humans; Infant; Infant, Newbor

1993
The use of primidone in neonates with theophylline-resistant apnea.
    American journal of diseases of children (1960), 1993, Volume: 147, Issue:2

    Topics: Apnea; Bradycardia; Drug Resistance; Humans; Infant, Newborn; Infant, Premature; Intensive Care Unit

1993
Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia or asystole.
    The New England journal of medicine, 1993, Apr-15, Volume: 328, Issue:15

    Topics: Adolescent; Adult; Aged; Bradycardia; Cardiac Pacing, Artificial; Disopyramide; Female; Follow-Up St

1993
The use of methylphenidate in the treatment of refractory neurocardiogenic syncope.
    Pacing and clinical electrophysiology : PACE, 1996, Volume: 19, Issue:5

    Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Bradycardia; Central Nervous S

1996
Bradycardia after heart transplantation: reversal with theophylline.
    Journal of the American College of Cardiology, 1996, Volume: 28, Issue:2

    Topics: Arrhythmia, Sinus; Bradycardia; Case-Control Studies; Coronary Disease; Female; Heart Rate; Heart Tr

1996
Bradycardia after heart transplantation: reversal with theophylline.
    Journal of the American College of Cardiology, 1997, Volume: 29, Issue:2

    Topics: Bradycardia; Heart Rate; Heart Transplantation; Humans; Purinergic P1 Receptor Antagonists; Theophyl

1997
The effect of theophylline on apnoea and hypoxaemic episodes in the premature neonate during the 1st 3 days after birth.
    Annals of tropical paediatrics, 1998, Volume: 18, Issue:3

    Topics: Apnea; Blood Pressure; Bradycardia; Bronchodilator Agents; Caffeine; Female; Gestational Age; Humans

1998
Adenosine modulates corticotropin and cortisol release during hypoxia in fetal sheep.
    American journal of obstetrics and gynecology, 1999, Volume: 180, Issue:5

    Topics: Adenosine; Adrenocorticotropic Hormone; Animals; Blood Pressure; Bradycardia; Female; Fetal Blood; F

1999
Intravenous theophylline--an alternative to temporary pacing in the management of bradycardia secondary to AV nodal block.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:3

    Topics: Aged; Bradycardia; Burns; Cardiac Pacing, Artificial; Female; Heart Block; Humans; Injections, Intra

2001
Prevention of apnea and bradycardia in low-birthweight infants.
    Pediatrics, 1975, Volume: 55, Issue:5

    Topics: Apnea; Birth Weight; Bradycardia; Carbon Dioxide; Female; Humans; Hydrogen-Ion Concentration; Infant

1975
Weaning very low birthweight infants from mechanical ventilation using intermittent mandatory ventilation and theophylline.
    Archives of disease in childhood, 1979, Volume: 54, Issue:1

    Topics: Apnea; Bradycardia; Humans; Hyaline Membrane Disease; Infant, Low Birth Weight; Infant, Newborn; Res

1979
[Prevention of neonatal apnea with theophylline (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1978, Volume: 126, Issue:11

    Topics: Apnea; Bradycardia; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Male; Tachycardia;

1978
[A case of bradycardia].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1975, Feb-15, Volume: 28, Issue:4

    Topics: Bradycardia; Electrocardiography; Humans; Hypertension; Male; Middle Aged; Obesity; Theophylline

1975
The xanthine treatment of apnea of prematurity.
    Pediatrics, 1975, Volume: 55, Issue:5

    Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature, Di

1975
The autonomic and hemodynamic effects of oral theophylline in patients with vasodepressor syncope.
    Archives of internal medicine, 1991, Volume: 151, Issue:12

    Topics: Administration, Oral; Adult; Autonomic Nervous System; Bradycardia; Female; Heart; Heart Rate; Human

1991
Apnoea, bradycardia, and oxygen saturation in preterm infants.
    Archives of disease in childhood, 1991, Volume: 66, Issue:4 Spec No

    Topics: Apnea; Bradycardia; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Longitudinal Studi

1991
Electrophysiologic effects of oral theophylline in sinus bradycardia.
    The American journal of cardiology, 1990, Apr-15, Volume: 65, Issue:15

    Topics: Aged; Arrhythmia, Sinus; Atropine; Bradycardia; Cardiac Pacing, Artificial; Electrocardiography; Ele

1990
[Effect of methylxanthines on periodic respiration and acid gastroesophageal reflux in newborn infants].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1990, Volume: 138, Issue:3

    Topics: Bradycardia; Caffeine; Citrates; Drug Combinations; Drug Therapy, Combination; Gastric Acidity Deter

1990
Mediation by adenosine of bradycardia in rat heart during graded global ischaemia.
    Pflugers Archiv : European journal of physiology, 1988, Volume: 412, Issue:6

    Topics: Adenosine; Animals; Atrioventricular Node; Bradycardia; Coronary Disease; Heart Rate; In Vitro Techn

1988
Infant apnea.
    Pediatric clinics of North America, 1986, Volume: 33, Issue:3

    Topics: Airway Obstruction; Apnea; Bradycardia; Caffeine; Cardiography, Impedance; Home Nursing; Humans; Inf

1986
Influence of continuous gastric suction on theophylline clearance in a newborn.
    Developmental pharmacology and therapeutics, 1985, Volume: 8, Issue:5

    Topics: Bradycardia; Female; Humans; Infant; Intubation, Gastrointestinal; Theophylline; Time Factors

1985
[Antagonism of circulation effect of adenosine by theophylline].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:3

    Topics: Adenine Nucleotides; Aminophylline; Animals; Arteries; Blood Circulation; Blood Platelets; Blood Pre

1970
[Therapeutic methods in bradycardiac stress insufficiency of elderly health resort patients].
    Munchener medizinische Wochenschrift (1950), 1973, Sep-07, Volume: 115, Issue:36

    Topics: 1-Propanol; Bradycardia; Heart Failure; Humans; Methods; Physical Therapy Modalities; Phytotherapy;

1973
[The therapy of cardiac insufficiency using Theo-Alvonal].
    Munchener medizinische Wochenschrift (1950), 1968, Jan-26, Volume: 110, Issue:4

    Topics: Adult; Aged; Blood Pressure; Bradycardia; Cardiac Glycosides; Digitalis Glycosides; Diuresis; Electr

1968