theophylline has been researched along with Body Weight in 127 studies
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested an aminophylline loading-dose protocol in which asthmatic patients presenting to an emergency department were given a half (3 mg/kg) IV loading dose based on total body weight (TBW) if they had taken a short-acting or sustained-release theophylline preparation within 12 or 24 hours, respectively, prior to arrival: otherwise, a full (6 mg/kg) loading dose was administered." | 9.06 | Aminophylline loading in asthmatic patients: a protocol trial. ( Marcus, RH; Parvin, CA; Stine, RJ, 1989) |
| "The literature is unclear as to whether theophylline loading doses should be based on total body weight (TBW) or ideal body weight (IBW)." | 9.05 | Volume of distribution of theophylline in acute exacerbations of reversible airway disease. Effect of body weight. ( Curtis, RA; Fischer, JH; Troyer, WG; Zell, M, 1985) |
| "5 mg/kg/h theophylline) were administered in that order and in reverse order to patients with apnea of prematurity." | 7.68 | Lack of a pharmacokinetic interaction between doxapram and theophylline in apnea of prematurity. ( Coutts, RT; Finer, NN; Jamali, F; Malek, F; Peliowski, A, 1991) |
| "Seven children from 3 to 14 years old with chronic steroid-dependent asthma were treated with methotrexate (MTX)." | 7.68 | Methotrexate treatment of severe asthma in children. ( Guss, S; Portnoy, J, 1992) |
| "The volume of distribution (Vd) of theophylline and the relevant aminophylline loading dose (LD) are usually calculated on the basis of total body weight (TBW)." | 7.67 | Effect of body weight on the volume of distribution of theophylline. ( Bonanno, A; Mirabella, A; Rizzo, A, 1988) |
| " infusion of theophylline until the onset of maximal seizures had no significant effect on the total dose and the serum and cerebrospinal fluid concentrations of theophylline at the pharmacologic endpoint." | 7.67 | Aspartame and phenylalanine do not enhance theophylline-induced seizures in rats. ( Levy, G; Zhi, JQ, 1989) |
| "Theophylline clearance was prospectively studied in eight pregnant asthmatic patients who were receiving maintenance doses of theophylline." | 7.67 | Theophylline clearance during pregnancy. ( Carter, BL; Driscoll, CE; Smith, GD, 1986) |
| "Administration of a thermogenic mixture of ephedrine, caffeine and theophylline to grossly obese (11-12 mo old) fa/fa Zucker rats led to a rapid decline in their body weight, which reached lean levels within 9-10 wk, and this postobese weight was maintained for another 5-6 wk." | 7.67 | Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture. ( Dulloo, AG; Miller, DS, 1987) |
| "Pharmacokinetic studies of theophylline were carried out in 12 Thai asthmatic children after oral administration of Elixir Quibron and Tablet Aminophylline." | 7.67 | Pharmacokinetics of oral theophylline in Thai asthmatic children. ( Geadsomnuig, S; Habananada, S; Koysooko, R; Pinthong, T; Tuchinda, M; Wattanapermpool, J, 1987) |
| " The free and total plasma and saliva concentrations of theophylline were measured during a dosing interval at steady state in nineteen asthmatic subjects receiving a once-daily theophylline preparation (Riker TCR-1)." | 7.67 | Determinants of free theophylline clearance in asthma. ( Alwazir, YA; Buss, DC; Campbell, IA; John, R; Lazarus, JH; Littley, M; Routledge, PA; Williams, PE, 1987) |
| " Measurements of 131I uptake by the thyroid gland, thyroid acinar cell height and protein-bound iodine failed to reveal an effect of theophylline in either control or hypothyroid animals although theophylline increased thyroid to body weight ratio in both groups." | 7.66 | Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats. ( Dasler, R; Fregly, MJ; Lutherer, LO; Tyler, PE, 1978) |
| "The effect of obesity on the total body clearance (Cltot) of theophylline was evaluated in nonsmokers and smokers with and without congestive heart failure (CHF)." | 7.66 | Theophylline clearance in obese patients in relation to smoking and congestive heart failure. ( Lanc, RA; Slaughter, RL, 1983) |
| "The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults." | 7.66 | Relationships between plasma theophylline clearance, liver volume and body weight in children and adults. ( Birkett, DJ; Goldin, A; Grygiel, JJ; Ogborne, M; Ward, H, 1983) |
| "Total body clearance (ClT) of theophylline was examined in 12 markedly obese patients and related to total body weight (TBW) and ideal body weight (IBW)." | 7.66 | Theophylline clearance: effect of marked obesity. ( Bauer, LA; Blouin, RA; Elgert, JF, 1980) |
| "Theophylline disposition was examined in 17 premature neonates (birth weight 760--1,480 g) at cessation of therapy for primary apnea Mean +/- SD of clearance (22." | 7.66 | Factors affecting theophylline pharmacokinetics in premature infants with apnea. ( Giacoia, G; Hilligoss, DM; Jusko, WJ; Koup, JR, 1980) |
| " BSA would serve as a practical alternative to LW for scaling adult dosage of metabolically eliminated drugs to children." | 5.31 | Developmental changes in the liver weight- and body weight-normalized clearance of theophylline, phenytoin and cyclosporine in children. ( Echizen, H; Kanamori, M; Takahashi, H, 2002) |
| "The pharmacokinetics of two slow release theophylline preparations "Theo-Dur" (T) containing theophylline only and "Phyllocontin" (P) containing aminophylline have been compared in 12 patients with asthma." | 5.06 | Methods of comparing pharmacokinetics of slow release preparations: a comparison of "Theo-Dur" and "Phyllocontin" in patients with asthma. ( Jackson, SH; Shah, K; Turner, P, 1986) |
| "5, or (3) apnea associated with a heart rate less than 100 beats per minute that required frequent stimulation (more than 20 episodes during a 16-hour period)." | 5.06 | Theophylline treatment in the extubation of infants weighing less than 1,250 grams: a controlled trial. ( Ballard, RA; Clyman, RI; Durand, DJ; Goodman, A; Ray, P, 1987) |
| "We tested an aminophylline loading-dose protocol in which asthmatic patients presenting to an emergency department were given a half (3 mg/kg) IV loading dose based on total body weight (TBW) if they had taken a short-acting or sustained-release theophylline preparation within 12 or 24 hours, respectively, prior to arrival: otherwise, a full (6 mg/kg) loading dose was administered." | 5.06 | Aminophylline loading in asthmatic patients: a protocol trial. ( Marcus, RH; Parvin, CA; Stine, RJ, 1989) |
| "The literature is unclear as to whether theophylline loading doses should be based on total body weight (TBW) or ideal body weight (IBW)." | 5.05 | Volume of distribution of theophylline in acute exacerbations of reversible airway disease. Effect of body weight. ( Curtis, RA; Fischer, JH; Troyer, WG; Zell, M, 1985) |
| " Body weight and age (post-conceptional age and post-natal age) were the most important factors associated with the clearance (CL) of theophylline in paediatric patients." | 4.93 | Theophylline: a review of population pharmacokinetic analyses. ( Jiang, DQ; Li, MX; Ma, YJ; Meng, JX; Wang, LQ; Wang, Y; Zhao, HH, 2016) |
| "Having observed in recent years that the theophylline dose requirements needed to attain peak serum concentrations of 10 to 20 micrograms/ml infrequently reached previously described mean values, we hypothesized that a downward shift in the range of dose requirements had occurred among patients with asthma." | 3.69 | Apparent decrease in population clearance of theophylline: implications for dosage. ( Asmus, MJ; Hendeles, L; Marshik, P; Milavetz, G; Teresi, ME; Weinberger, MM, 1997) |
| " A total of 230 males were initially injected with diethylnitrosamine (200 mg/kg body weight, ip) or saline as controls and 2 wk later were fed on diet or drinking water supplemented as follows for 6 wk: 5% regular instant coffee; 5% decaffeinated instant coffee; freshly brewed coffee, 8 g in 140 ml water; 0." | 3.69 | Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats. ( Hasegawa, R; Imaida, K; Ito, N; Ogiso, T; Shirai, T, 1995) |
| "Seven children from 3 to 14 years old with chronic steroid-dependent asthma were treated with methotrexate (MTX)." | 3.68 | Methotrexate treatment of severe asthma in children. ( Guss, S; Portnoy, J, 1992) |
| " The methylxanthines; caffeine, theophylline and theobromine, were administered via drinking water in the proportions occurring in tea, at a dose of 50, 1 and 2 mg/kg body-weight respectively to Wistar albino rats throughout pregnancy and for up to the 14th day of lactation." | 3.68 | The effect of methylxanthines on milk volume and composition, and growth of rat pups. ( Grimble, RF; Hart, AD, 1990) |
| "5 mg/kg/h theophylline) were administered in that order and in reverse order to patients with apnea of prematurity." | 3.68 | Lack of a pharmacokinetic interaction between doxapram and theophylline in apnea of prematurity. ( Coutts, RT; Finer, NN; Jamali, F; Malek, F; Peliowski, A, 1991) |
| "Theophylline kinetics were examined in five patients with hyperthyroidism before and after treatment with carbimazole." | 3.67 | Influence of thyroid function on theophylline kinetics. ( Follath, F; Otten, M; Staub, JJ; Vozeh, S, 1984) |
| "We examined renal function and Na+ balance in a patient with congestive heart failure who was treated with demeclocycline (DMC) on three separate occasions under strict metabolic balance conditions." | 3.67 | Demeclocycline-induced natriuresis and renal insufficiency: in vivo and in vitro studies. ( Braden, GL; Cox, M; Geheb, MA; Shook, A; Singer, I, 1985) |
| " Total body weight (TBW), height, skinfold thickness (at three sites), and theophylline levels around an intravenous aminophylline dose were measured." | 3.67 | Influence of body fat on the volume of distribution of theophylline. ( Ensom, RJ; Jewesson, PJ, 1985) |
| " infusion of theophylline until the onset of maximal seizures had no significant effect on the total dose and the serum and cerebrospinal fluid concentrations of theophylline at the pharmacologic endpoint." | 3.67 | Aspartame and phenylalanine do not enhance theophylline-induced seizures in rats. ( Levy, G; Zhi, JQ, 1989) |
| "The volume of distribution (Vd) of theophylline and the relevant aminophylline loading dose (LD) are usually calculated on the basis of total body weight (TBW)." | 3.67 | Effect of body weight on the volume of distribution of theophylline. ( Bonanno, A; Mirabella, A; Rizzo, A, 1988) |
| " The free and total plasma and saliva concentrations of theophylline were measured during a dosing interval at steady state in nineteen asthmatic subjects receiving a once-daily theophylline preparation (Riker TCR-1)." | 3.67 | Determinants of free theophylline clearance in asthma. ( Alwazir, YA; Buss, DC; Campbell, IA; John, R; Lazarus, JH; Littley, M; Routledge, PA; Williams, PE, 1987) |
| "Pharmacokinetic studies of theophylline were carried out in 12 Thai asthmatic children after oral administration of Elixir Quibron and Tablet Aminophylline." | 3.67 | Pharmacokinetics of oral theophylline in Thai asthmatic children. ( Geadsomnuig, S; Habananada, S; Koysooko, R; Pinthong, T; Tuchinda, M; Wattanapermpool, J, 1987) |
| "A dietary-induced animal model of obesity was examined to assess the mechanisms of obesity-altered changes in theophylline clearance and distribution." | 3.67 | Theophylline disposition in obese rats. ( Jusko, WJ; Shum, L, 1984) |
| "Administration of a thermogenic mixture of ephedrine, caffeine and theophylline to grossly obese (11-12 mo old) fa/fa Zucker rats led to a rapid decline in their body weight, which reached lean levels within 9-10 wk, and this postobese weight was maintained for another 5-6 wk." | 3.67 | Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture. ( Dulloo, AG; Miller, DS, 1987) |
| "02% caffeine in drinking water ad libitum before and/or during pregnancy were examined on gestational day 21." | 3.67 | Effects of maternal caffeine ingestion on the perinatal cerebrum. ( Arima, M; Nakazawa, K; Tanaka, H, 1987) |
| "Theophylline clearance was prospectively studied in eight pregnant asthmatic patients who were receiving maintenance doses of theophylline." | 3.67 | Theophylline clearance during pregnancy. ( Carter, BL; Driscoll, CE; Smith, GD, 1986) |
| " Measurements of 131I uptake by the thyroid gland, thyroid acinar cell height and protein-bound iodine failed to reveal an effect of theophylline in either control or hypothyroid animals although theophylline increased thyroid to body weight ratio in both groups." | 3.66 | Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats. ( Dasler, R; Fregly, MJ; Lutherer, LO; Tyler, PE, 1978) |
| "Serum concentrations of theophylline following intravenous and oral administration of aminophylline were studied in asthmatic children, 2--17 years of age." | 3.66 | Serum concentrations of theophylline in children following the administration of doses generally recommended: new dosage regimen required. ( Aas, K; Bjerve, KS; Holmen, TL; Rugstad, HE; Selvig, K, 1979) |
| "Total body clearance (ClT) of theophylline was examined in 12 markedly obese patients and related to total body weight (TBW) and ideal body weight (IBW)." | 3.66 | Theophylline clearance: effect of marked obesity. ( Bauer, LA; Blouin, RA; Elgert, JF, 1980) |
| "The effect of obesity on the total body clearance (Cltot) of theophylline was evaluated in nonsmokers and smokers with and without congestive heart failure (CHF)." | 3.66 | Theophylline clearance in obese patients in relation to smoking and congestive heart failure. ( Lanc, RA; Slaughter, RL, 1983) |
| "The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults." | 3.66 | Relationships between plasma theophylline clearance, liver volume and body weight in children and adults. ( Birkett, DJ; Goldin, A; Grygiel, JJ; Ogborne, M; Ward, H, 1983) |
| "The effect of administration of theophylline, thyroxine (T4), or a combination of the two, for 14 days on body weight, food intake, serum concentrations of T4 and 3,5,3'-triiodothyronine (T3), and on the rate of 5'-monodieodination of T4 to T3 by hepatic and renal homogenates was evaluated." | 3.66 | Effect of theophylline on thyroid status in the rat. ( Fregly, MJ; Scammell, JG, 1982) |
| "Theophylline disposition was examined in 17 premature neonates (birth weight 760--1,480 g) at cessation of therapy for primary apnea Mean +/- SD of clearance (22." | 3.66 | Factors affecting theophylline pharmacokinetics in premature infants with apnea. ( Giacoia, G; Hilligoss, DM; Jusko, WJ; Koup, JR, 1980) |
| "Among nonsmokers, the peak concentration (C(max)) and area under concentration-time curve from 0 to infinity [AUC(0-infinity)] of tizanidine did not differ significantly between females and males." | 2.73 | Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine. ( Backman, JT; Neuvonen, PJ; Schröder, MT, 2008) |
| "In infants with renal failure, serum creatinine and creatinine clearance returned to normal in the neonatal period, and the increased beta2M excretion normalized by age 6 weeks." | 2.72 | Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. ( Bhat, MA; Makhdoomi, MS; Mufti, MH; Shah, ZA, 2006) |
| "Allometric approaches are widely used for interspecies scaling for the prediction of pharmacokinetic (PK) parameters during drug development." | 2.58 | Multistep Unified Models Using Prior Knowledge for the Prediction of Drug Clearance in Neonates and Infants. ( Forshee, R; Jiang, Z; Mahmood, I; Tegenge, MA, 2018) |
| "Michaelis-Menten pharmacokinetic parameters for theophylline were estimated in a three-month infant following an accidental overdose of intravenous aminophylline." | 2.40 | Aspects of theophylline clearance in children. ( Anderson, BJ; Holford, NH; Woollard, GA, 1997) |
| " When models were evaluated with validation data, a single-exponent model overpredicted clearance and dosing rate in premature neonates and adults with a mean prediction error of ≥50%." | 1.48 | Age- and Bodyweight-dependent Allometric Exponent Model for Scaling Clearance and Maintenance Dose of Theophylline From Neonates to Adults. ( Mahmood, I; Tegenge, MA, 2018) |
| "This study elucidated the steatohepatitis via matrix metallopeptidase 9 (MMP-9) and tumor necrosis factor α (TNFα), and related lipolysis via hormone sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) by KMUP-1." | 1.43 | Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice. ( Chai, CY; Chang, CT; Chen, IJ; Chen, YH; Dai, ZK; Huang, HT; Kuo, KK; Wu, BN, 2016) |
| "This study examined the effects of chronic administration of adenosine and CGS 21680 hydrochloride (adenosine A(2A) receptor agonist) on motor nerve conduction velocity (MNCV), nerve blood flow (NBF) and histology of sciatic nerve in animal model of diabetic neuropathy." | 1.33 | Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy. ( Arun, KH; Kaul, CL; Kumar, S; Sharma, SS, 2005) |
| " The half-life of elimination from plasma was more than four times longer in Cyp1a2(-/-) than Cyp1(+/+) mice and more than 10 times different after TCDD pretreatment." | 1.33 | Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice. ( Curran, CP; Dalton, TP; Derkenne, S; Dragin, N; Nebert, DW; Shertzer, HG, 2005) |
| "Allometric scaling is an empirical examination of the relationships between the pharmacokinetic parameters and size (usually body weight, ratio of organ- and body weight, breathing number, etc." | 1.30 | [Interspecies allometric scaling in pharmacokinetics of drugs]. ( Sylvia, M, 1998) |
| " This study was undertaken in adult male New Zealand rabbits to assess the effect of 3 weeks of dosing with NIS (1 mg." | 1.30 | A high cholesterol diet blocks the effect of calcium channel blockers on the uptake of sugars in rabbit intestine. ( Hyson, DH; Kappagoda, CT; Keelan, M; Thomson, AB, 1997) |
| "Post-theophylline HPV was divided by pre-theophylline HPV to normalize individual variation." | 1.30 | Effect of theophylline on hypoxic pulmonary vasoconstriction in awake rats. ( Arisaka, Y; Kato, S; Sato, S; Takahashi, H; Tomoike, H; Yuki, H, 1997) |
| " It also was noticed that young dogs have a slower elimination half-life (1 week old, t 1/2 beta = 987 minutes) than do older animals (8 weeks old, t 1/2 beta = 138 minutes)." | 1.29 | Effect of age on theophylline pharmacokinetics in dogs. ( Alberola, J; Arboix, M; Pérez, Y; Puigdemont, A, 1993) |
| "The role of bioelectrical impedance (BI) analysis in determining slow-release theophylline dosage was evaluated in fifteen healthy subjects given a standard 200 mg dose." | 1.29 | Individual theophylline dosing based on bioelectrical impedance analysis. ( Charles, BG; Sidhu, JS; Smithurst, BA; Triggs, EJ, 1993) |
| " A second group of females was dosed daily for 19 days." | 1.28 | Assessment of a short-term reproductive and developmental toxicity screen. ( Chapin, RE; Harris, MW; Jokinen, MP; Lockhart, AC, 1992) |
| " The strongest statistical correlations were found between the logarithm of theophylline half-life (t1/2) and the postnatal age (r = 0." | 1.28 | Maturational changes of theophylline pharmacokinetics in preterm infants. ( Dothey, CI; Kaw, S; King, KC; Tserng, KY, 1989) |
| "Concomitant use of the bronchodilator theophylline and the antibacterial agent enoxacin has been associated with significant neurologic and other adverse effects." | 1.28 | Effect of enoxacin on theophylline neurotoxicity. ( Hoffman, A; Levy, G, 1989) |
| " The dosage rate of theophylline (mg/hour) can be estimated from predicted clearance (L/kg/hour) times desired steady-state serum concentration (mg/L)." | 1.28 | A prospective evaluation of elevated serum theophylline concentrations to determine if high concentrations are predictable. ( Cranberg, JA; Ganz, MA; Greenberger, PA; Hubler, GL, 1991) |
| " Animals were exposed to cigarette smoke for 20 min each in the morning and evening every day for 26 days in the pharmacokinetic study, and 27 days for the enzyme assays." | 1.28 | Influences of long-term cigarette smoke exposure on pharmacokinetics of theophylline, and on liver microsomal enzymes in rats. ( Araki, Y; Eto, K; Furuno, K; Gomita, Y; Mimaki, Y; Okazaki, M, 1992) |
| "Caffeine has been associated with a number of reproductive and developmental effects in animals and humans." | 1.28 | Somatic development of the infant monkey following in utero exposure to caffeine. ( Gilbert, SG; Rice, DC, 1991) |
| "Theophylline-treated animals had a significantly increased urinary calcium excretion (p less than 0." | 1.28 | Effect of theophylline on calcium metabolism and circulating vitamin D metabolites. ( Duncan, WE; Fortenbery, EJ; McDermott, MT, 1990) |
| "Dietary protein deficiency led to a significant reduction of total body clearance from approximately 73 to 45 ml/hr/kg in the 2 and 14 month old rats." | 1.28 | The effects of age and dietary protein restriction on the pharmacokinetics of theophylline in the rat. ( Jung, D; Nanavaty, M, 1990) |
| "The pharmacokinetics of theophylline at two different dosage levels were studied in six adult volunteers." | 1.27 | Evaluation of the effect of nonlinear kinetics on dosage adjustments of theophylline. ( Benson, J; Goetz, D; Johnson, D; Moore, K; Pancorbo, S; Vaida, A, 1983) |
| " Also observed in rats dosed with theophylline via the diet was an increased severity of chronic nephropathy in males, especially at the high dose." | 1.27 | Subchronic toxicity of orally administered (gavage and dosed-feed) theophylline in Fischer 344 rats and B6C3F1 mice. ( Collins, JJ; Elwell, MR; Heath, JE; Lamb, JC; Makovec, GT; Manus, AG, 1988) |
| "When caffeine was added at two concentrations, 0." | 1.27 | Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat. ( Whiting, SJ; Whitney, HL, 1987) |
| "This theophylline-induced increase in inulin clearance after 30 minutes of ischemia was accompanied by an increase in renal plasma flow." | 1.27 | Effect of theophylline on the initiation phase of postischemic acute renal failure in rats. ( Bidani, AK; Churchill, PC; Lin, JJ, 1986) |
| "Gestational age, gender, duration of treatment, body weight, and Apgar scores were not found to correlate significantly with theophylline clearance." | 1.27 | Factors influencing theophylline disposition in 179 newborns. ( Erkan, NV; Gal, P; Gilman, JT; Hersh, CB; Levine, RS, 1986) |
| "Theophylline was the main urinary metabolite." | 1.27 | The fate of chronically consumed caffeine in the monkey (Macaca fascicularis). ( Gilbert, SG; Klassen, RD; Rice, DC; Stavric, B, 1985) |
| " In the gavage study, 400 mg/kg was acutely toxic for both species, but mice and rats differed in that this same daily dose administered as two separate doses of 200 mg/kg was acutely toxic in rats but not in mice." | 1.27 | Studies on the short-term toxicity of theophylline in rats and mice. ( Bristol, DW; Collins, JJ; Heath, JE; Lamb, JC; Lindamood, C; Prejean, JD, 1988) |
| "Influence of chronic administration of theophylline on feeding behavior in rats was studied in contrast with the saline controls under a 12 hr light-dark cycle." | 1.26 | [A shift to diurnal feeding following chronic administration of theophylline in rats]. ( Fukushima, M; Kodama, J; Sakata, T, 1976) |
| " These guidelines facilitate initial theophylline dosage in older patients with liver and cardiac disease and provide a rational basis for interpreting serum concentration measurements and adjustment of drug therapy." | 1.26 | Intravenous theophylline therapy: nomogram guidelines. ( Jusko, WJ; Koup, JR; Kuritzky, P; Schentag, JJ; Vance, JW, 1977) |
| "The pharmacokinetics of two unmatched populations of asthmatic children, one from an asthmatic convalescent center in Denver and the other from an urban outpatient clinic, are compared after single and repeated dosing of a new asthma formulation, oxtriphylline syrup." | 1.26 | Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup. ( Bell, T; Danish, M; Katsampes, C; Lecks, H; Ragni, M; Rasmussen, C; Simon, T; Yaffe, S, 1980) |
| " Rat pups were given either aminophylline, theophylline, or caffeine in a dosage of 40 mg/kg or 80 mg/kg daily from the second postnatal day through 20 days of age." | 1.26 | A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain. ( Fuller, GN; Wiggins, RC, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 86 (67.72) | 18.7374 |
| 1990's | 26 (20.47) | 18.2507 |
| 2000's | 11 (8.66) | 29.6817 |
| 2010's | 4 (3.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tegenge, MA | 2 |
| Mahmood, I | 2 |
| Jiang, Z | 1 |
| Forshee, R | 1 |
| Wu, BN | 1 |
| Kuo, KK | 1 |
| Chen, YH | 1 |
| Chang, CT | 1 |
| Huang, HT | 1 |
| Chai, CY | 1 |
| Dai, ZK | 1 |
| Chen, IJ | 1 |
| Ma, YJ | 1 |
| Jiang, DQ | 1 |
| Meng, JX | 1 |
| Li, MX | 1 |
| Zhao, HH | 1 |
| Wang, Y | 1 |
| Wang, LQ | 1 |
| Turner, CP | 1 |
| Yan, H | 1 |
| Schwartz, M | 1 |
| Othman, T | 1 |
| Rivkees, SA | 1 |
| Kanamori, M | 1 |
| Takahashi, H | 2 |
| Echizen, H | 1 |
| Kumar, S | 1 |
| Arun, KH | 1 |
| Kaul, CL | 1 |
| Sharma, SS | 1 |
| Derkenne, S | 1 |
| Curran, CP | 1 |
| Shertzer, HG | 1 |
| Dalton, TP | 1 |
| Dragin, N | 1 |
| Nebert, DW | 1 |
| Stricker, EM | 1 |
| Zimmerman, MB | 1 |
| Friedman, MI | 1 |
| Zigmond, MJ | 1 |
| Tengowski, MW | 1 |
| Sutovsky, P | 1 |
| Hedlund, LW | 1 |
| Guyot, DJ | 1 |
| Burkhardt, JE | 1 |
| Thompson, WE | 1 |
| Sutovsky, M | 1 |
| Johnson, GA | 1 |
| Inoue, H | 1 |
| Kobayashi-Hattori, K | 1 |
| Horiuchi, Y | 1 |
| Oishi, Y | 1 |
| Arai, S | 1 |
| Takita, T | 1 |
| Bhat, MA | 1 |
| Shah, ZA | 1 |
| Makhdoomi, MS | 1 |
| Mufti, MH | 1 |
| Backman, JT | 1 |
| Schröder, MT | 1 |
| Neuvonen, PJ | 1 |
| Hirsh, K | 1 |
| Vozeh, S | 1 |
| Otten, M | 1 |
| Staub, JJ | 1 |
| Follath, F | 1 |
| Shum, L | 1 |
| Jusko, WJ | 3 |
| Patano, T | 1 |
| Slaughter, RL | 1 |
| Lanc, RA | 1 |
| Gotz, VP | 1 |
| Russell, WL | 1 |
| Lopez, LM | 1 |
| Grygiel, JJ | 1 |
| Ward, H | 1 |
| Ogborne, M | 1 |
| Goldin, A | 1 |
| Birkett, DJ | 1 |
| Pancorbo, S | 1 |
| Benson, J | 1 |
| Goetz, D | 1 |
| Moore, K | 1 |
| Vaida, A | 1 |
| Johnson, D | 1 |
| Pfaffman, MA | 1 |
| Hilman, R | 1 |
| Darby, A | 1 |
| Denenberg, VH | 1 |
| Zeidner, LP | 1 |
| Thoman, EB | 1 |
| Kramer, P | 1 |
| Rowe, JC | 1 |
| Philipps, AF | 1 |
| Raye, JR | 1 |
| Simmons, SM | 1 |
| Camp, RB | 1 |
| Mungall, DR | 1 |
| Bailey, WC | 1 |
| Melethil, S | 1 |
| Carlson, JD | 1 |
| Haug, MT | 1 |
| Scammell, JG | 1 |
| Fregly, MJ | 2 |
| Fuller, GN | 1 |
| Wiggins, RC | 1 |
| Hendeles, L | 2 |
| Vaughan, L | 1 |
| Weinberger, M | 1 |
| Smith, G | 1 |
| Bell, T | 1 |
| Yaffe, S | 1 |
| Lecks, H | 1 |
| Danish, M | 1 |
| Ragni, M | 1 |
| Simon, T | 1 |
| Rasmussen, C | 1 |
| Katsampes, C | 1 |
| Blouin, RA | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study Aimed at Determining the Relation Between the Administered Dose and Exposure to Immunosuppressive Medication in Children After Solid Organ Transplantation[NCT01767350] | 60 participants (Actual) | Observational | 2013-02-28 | Completed | |||
| The Effect of Aminophylline on Preventing Acute Kidney Injury in Pediatric Patients Undergoing Open Heart Surgery[NCT03897335] | Phase 3 | 80 participants (Anticipated) | Interventional | 2019-02-07 | Recruiting | ||
| [NCT02276170] | 9 participants (Actual) | Observational | 2014-10-31 | Terminated (stopped due to insufficient rate of accrual) | |||
| Perioperative Aminophylline to Improve High Risk Renal Graft Outcome- a Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT01759862] | 50 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia Plus Magnesium Sulphate (MgSO4) Versus Therapeutic Hypothermia Plus Placebo in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy[NCT01646619] | Phase 3 | 300 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The investigators will measure blood creatinine on post-operative day 5 and using the Schwartz equation will calculate estimated glomerular filtration rate (GFR) to determine kidney function. (NCT01759862)
Timeframe: 5 days
| Intervention | ml/min/1.73m2 (Mean) |
|---|---|
| Aminophylline | 67.39 |
| Control | 80.48 |
The investigators will use the same cores that are obtained during routine 6 months protocol biopsies to quantify the amount of fibrosis (NCT01759862)
Timeframe: 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Aminophylline | 11 |
| Control | 14 |
urinary NGAL(Neutrophil gelatinase-associated lipocalin) is a biomarker for kidney injury. NGAL levels 12h post-transplant were found to be a marker for development of delayed graft function and need for dialysis post-transplant. NGAL levels are corrected for urine creatinine. (NCT01759862)
Timeframe: 12 hours post transplant
| Intervention | ng/mg (Median) |
|---|---|
| Aminophylline | 300.5 |
| Control | 425.4 |
3 reviews available for theophylline and Body Weight
| Article | Year |
|---|---|
Multistep Unified Models Using Prior Knowledge for the Prediction of Drug Clearance in Neonates and Infants.
Topics: Administration, Intravenous; Adolescent; Adult; Age Factors; Alfentanil; Body Weight; Busulfan; Chil | 2018 |
Theophylline: a review of population pharmacokinetic analyses.
Topics: Body Weight; Humans; Models, Biological; Nonlinear Dynamics; Software; Theophylline | 2016 |
Aspects of theophylline clearance in children.
Topics: Accidents; Adolescent; Adult; Age Factors; Algorithms; Aminophylline; Body Weight; Bronchiolitis; Br | 1997 |
7 trials available for theophylline and Body Weight
| Article | Year |
|---|---|
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial.
Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma | 2006 |
Effects of gender and moderate smoking on the pharmacokinetics and effects of the CYP1A2 substrate tizanidine.
Topics: Adrenergic alpha-Agonists; Adult; Area Under Curve; Blood Pressure; Body Weight; Caffeine; Clonidine | 2008 |
Aminophylline loading in asthmatic patients: a protocol trial.
Topics: Adolescent; Adult; Aged; Aging; Aminophylline; Asthma; Body Weight; Clinical Trials as Topic; Emerge | 1989 |
Theophylline treatment in the extubation of infants weighing less than 1,250 grams: a controlled trial.
Topics: Apnea; Birth Weight; Body Weight; Clinical Trials as Topic; Humans; Infant, Low Birth Weight; Infant | 1987 |
Methods of comparing pharmacokinetics of slow release preparations: a comparison of "Theo-Dur" and "Phyllocontin" in patients with asthma.
Topics: Adult; Aged; Asthma; Body Weight; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Middl | 1986 |
Volume of distribution of theophylline in acute exacerbations of reversible airway disease. Effect of body weight.
Topics: Adolescent; Adult; Anthropometry; Asthma; Body Weight; Bronchial Spasm; Female; Humans; Kinetics; Ma | 1985 |
Dysmenorrhea. A multifaceted syndrome.
Topics: Adolescent; Adult; Body Weight; Clinical Trials as Topic; Dysmenorrhea; Female; Humans; Maleates; Ph | 1969 |
117 other studies available for theophylline and Body Weight
| Article | Year |
|---|---|
Age- and Bodyweight-dependent Allometric Exponent Model for Scaling Clearance and Maintenance Dose of Theophylline From Neonates to Adults.
Topics: Adult; Aging; Body Weight; Child; Child, Preschool; Drug Dosage Calculations; Female; Humans; Infant | 2018 |
Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Diet, High-Fat; Fatty Liver; Interleukin-10; Li | 2016 |
A1 adenosine receptor activation induces ventriculomegaly and white matter loss.
Topics: Adenosine; Animals; Animals, Newborn; Body Weight; Cell Count; Cerebral Cortex; Cerebral Ventricles; | 2002 |
Developmental changes in the liver weight- and body weight-normalized clearance of theophylline, phenytoin and cyclosporine in children.
Topics: Administration, Oral; Adolescent; Age Factors; Aryl Hydrocarbon Hydroxylases; Body Surface Area; Bod | 2002 |
Effects of adenosine and adenosine A2A receptor agonist on motor nerve conduction velocity and nerve blood flow in experimental diabetic neuropathy.
Topics: Adenosine; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relat | 2005 |
Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.
Topics: Animals; Area Under Curve; Blotting, Western; Body Weight; Chromatography, High Pressure Liquid; Cyt | 2005 |
Caffeine restores feeding response to 2-deoxy-D-glucose in 6-hydroxydopamine-treated rats.
Topics: Animals; Blood Glucose; Body Weight; Caffeine; Deoxyglucose; Eating; Feeding Behavior; Male; Oxidopa | 1977 |
Reproductive cytotoxicity is predicted by magnetic resonance microscopy and confirmed by ubiquitin-proteasome immunohistochemistry in a theophylline-induced model of rat testicular and epididymal toxicity.
Topics: Animals; Apoptosis; Body Weight; Epididymis; Immunohistochemistry; In Situ Nick-End Labeling; Magnet | 2005 |
Regulation of the body fat percentage in developmental-stage rats by methylxanthine derivatives in a high-fat diet.
Topics: Abdominal Fat; Animals; Body Weight; Caffeine; Cholesterol; Diet; Dietary Fats; Eating; Liver; Male; | 2006 |
Central nervous system pharmacology of the dietary methylxanthines.
Topics: Acetylcholine; Adolescent; Adult; Aged; Body Weight; Caffeine; Central Nervous System; Diet; Dopamin | 1984 |
Influence of thyroid function on theophylline kinetics.
Topics: Adult; Body Weight; Carbimazole; Chromatography, High Pressure Liquid; Female; Humans; Hyperthyroidi | 1984 |
Theophylline disposition in obese rats.
Topics: Animals; Body Composition; Body Weight; Chromatography, High Pressure Liquid; Dietary Fats; Female; | 1984 |
Aminophylline confusion.
Topics: Aminophylline; Body Weight; Humans; Theophylline | 1983 |
Theophylline clearance in obese patients in relation to smoking and congestive heart failure.
Topics: Adult; Aged; Body Weight; Female; Heart Failure; Humans; Male; Metabolic Clearance Rate; Middle Aged | 1983 |
Evaluation of the "condition correction factor" method of estimating theophylline clearance.
Topics: Adult; Aged; Body Weight; Female; Humans; Individuality; Male; Metabolic Clearance Rate; Middle Aged | 1983 |
Relationships between plasma theophylline clearance, liver volume and body weight in children and adults.
Topics: Adult; Aging; Body Weight; Child; Child, Preschool; Female; Humans; Liver; Male; Middle Aged; Organ | 1983 |
Evaluation of the effect of nonlinear kinetics on dosage adjustments of theophylline.
Topics: Administration, Oral; Adult; Body Weight; Dose-Response Relationship, Drug; Humans; Kinetics; Male; | 1983 |
Contractile and relaxing activity of arterial smooth muscle from streptozotocin-diabetic rats.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Insulin; Male; Muscle, | 1980 |
Effects of theophylline on behavioral state development in the newborn rabbit.
Topics: Aging; Animals; Animals, Newborn; Arousal; Behavior, Animal; Body Weight; Exploratory Behavior; Kine | 1982 |
The use of theophylline clearance to design an oral aminophylline regimen.
Topics: Administration, Oral; Adult; Aged; Aminophylline; Asthma; Body Weight; Female; Humans; Kinetics; Lun | 1982 |
Predictability of theophylline levels.
Topics: Body Weight; Humans; Kinetics; Male; Middle Aged; Theophylline | 1982 |
Effect of theophylline on thyroid status in the rat.
Topics: Animals; Body Weight; Eating; Growth; Liver; Male; Proteins; Rats; Rats, Inbred Strains; Theophyllin | 1982 |
A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain.
Topics: Aging; Aminophylline; Animals; Body Weight; Brain; Caffeine; Intracellular Membranes; Myelin Sheath; | 1981 |
Influence of gender on theophylline dosage requirements in children with chronic asthma.
Topics: Adolescent; Asthma; Body Weight; Child; Child, Preschool; Chronic Disease; Female; Humans; Male; Met | 1981 |
Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup.
Topics: Administration, Oral; Aging; Body Height; Body Weight; Child; Choline; Female; Humans; Kinetics; Mal | 1980 |
Theophylline clearance: effect of marked obesity.
Topics: Adult; Aged; Body Weight; Female; Heart Failure; Humans; Kidney Diseases; Male; Metabolic Clearance | 1980 |
Factors affecting theophylline pharmacokinetics in premature infants with apnea.
Topics: Age Factors; Apnea; Body Weight; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Kinet | 1980 |
Unbound total (plasma) clearance approach in interspecies pharmacokinetics correlation: theophylline-cimetidine interaction.
Topics: Animals; Blood Proteins; Body Weight; Cimetidine; Dogs; Drug Interactions; Humans; Metabolic Clearan | 1995 |
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
Topics: Administration, Oral; Animals; Biological Assay; Body Weight; Caffeine; Coffee; Diethylnitrosamine; | 1995 |
Individual theophylline dosing based on bioelectrical impedance analysis.
Topics: Adolescent; Adult; Body Composition; Body Weight; Delayed-Action Preparations; Electric Impedance; F | 1993 |
Effect of age on theophylline pharmacokinetics in dogs.
Topics: Aging; Animals; Body Weight; Chromatography, High Pressure Liquid; Dogs; Half-Life; Male; Metabolic | 1993 |
Effects of breed and adipose depot location on responsiveness and sensitivity to adrenergic stimulation in ovine adipose tissue.
Topics: Adipocytes; Adipose Tissue; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Analysis of Varia | 1996 |
A high cholesterol diet blocks the effect of calcium channel blockers on the uptake of sugars in rabbit intestine.
Topics: Animals; Biological Transport; Body Weight; Calcium Channel Blockers; Carbohydrates; Cholesterol, Di | 1997 |
Reproductive toxicology. Theophylline.
Topics: Alopecia; Animals; Birth Weight; Body Weight; Epididymis; Female; Fertility; Litter Size; Liver; Mal | 1997 |
Effect of theophylline on hypoxic pulmonary vasoconstriction in awake rats.
Topics: Animals; Blood Gas Analysis; Body Weight; Hemodynamics; Hemoglobins; Hydrogen-Ion Concentration; Hyp | 1997 |
Neonatal cerebral hypoxia-ischemia: the effect of adenosine receptor antagonists.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Blood Glucose; Body Temperature; Body Weight; Brain; | 1997 |
Apparent decrease in population clearance of theophylline: implications for dosage.
Topics: Adolescent; Age Factors; Asthma; Body Weight; Bronchodilator Agents; Child; Child, Preschool; Chroni | 1997 |
Changing bone marrow micro-environment during development of acute myeloid leukaemia in rats.
Topics: Acute Disease; Animals; Body Weight; Bone Marrow; Cell Cycle; Hematopoiesis; Hydrogen-Ion Concentrat | 1998 |
An adenosine kinase inhibitor attenuates tactile allodynia in a rat model of diabetic neuropathic pain.
Topics: Adenosine Kinase; Animals; Anti-Bacterial Agents; Blood Glucose; Body Weight; Diabetes Mellitus, Exp | 1999 |
[Interspecies allometric scaling in pharmacokinetics of drugs].
Topics: Animals; Body Weight; Cats; Dogs; Drug Combinations; Humans; Mice; Organ Size; Papaverine; Parasympa | 1998 |
Biotransformation of theophylline in cirrhotic rats induced by biliary obstruction.
Topics: Animals; Area Under Curve; Biotransformation; Body Weight; Bronchodilator Agents; Cholestasis; Half- | 1999 |
Teratogenic and fetal toxicity following intravenous theophylline administration in pregnant rabbits is related to maternal drug plasma levels.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Dose-Response Relationship, Drug; | 2000 |
Effects of niosomal cisplatin and combination of the same with theophylline and with activated macrophages in murine B16F10 melanoma model.
Topics: Animals; Antineoplastic Agents; Body Weight; Cisplatin; Combined Modality Therapy; Female; Leukocyte | 2002 |
Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney.
Topics: Aminophylline; Animals; Antineoplastic Agents; Apoptosis; Body Weight; Caffeine; Catalase; Cisplatin | 2002 |
Defective early phase insulin release in perifused isolated pancreatic islets of spiny mice (Acomys cahirinus).
Topics: Age Factors; Animals; Arginine; Body Weight; Cyclic AMP; Cytochalasin B; Glucose; In Vitro Technique | 1975 |
The influence of various factors on fluid secretion by in vitro salivary glands of ixodid Ticks.
Topics: Acetylcholine; Animals; Body Weight; Cyclic AMP; Dopamine; Eating; Epinephrine; Female; Hemolymph; I | 1976 |
[Xantinol-nicotinate in primary type-V hyperlipoproteinaemia (author's transl)].
Topics: Adult; Aged; Body Weight; Cholesterol; Chylomicrons; Fatty Acids, Nonesterified; Female; Humans; Hyp | 1976 |
Washington University Case Conference: Theophylline toxicity.
Topics: Aged; Aspartate Aminotransferases; Body Weight; Chromatography, High Pressure Liquid; Creatine Kinas | 1978 |
Serum concentrations of theophylline in children following the administration of doses generally recommended: new dosage regimen required.
Topics: Administration, Oral; Adolescent; Aminophylline; Asthma; Body Weight; Child; Child, Preschool; Half- | 1979 |
Intravenous aminophylline.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aminophylline; Asthma; Body Weight; Child; Half-Life | 1979 |
Impaired taste discrimination against quinine following chronic administration of theophylline in rats.
Topics: Animals; Body Weight; Discrimination, Psychological; Dose-Response Relationship, Drug; Extinction, P | 1978 |
Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats.
Topics: Amitrole; Animals; Blood Pressure; Body Weight; Diet; Drug Evaluation, Preclinical; Growth; Heart Ra | 1978 |
Insulin and glucagon secretion by pancreatic islets from nondiabetic and diabetic sand rats (Psammomys obesus).
Topics: Animals; Body Weight; Diabetes Mellitus; Female; Glucagon; Glucose; Glyceraldehyde; In Vitro Techniq | 1976 |
Intravenous theophylline therapy: nomogram guidelines.
Topics: Adult; Age Factors; Aged; Body Weight; Female; Heart Diseases; Humans; Liver Diseases; Male; Middle | 1977 |
[A shift to diurnal feeding following chronic administration of theophylline in rats].
Topics: Animals; Body Weight; Circadian Rhythm; Eating; Female; Rats; Theophylline | 1976 |
Feeding patterns of theophyllinized rats and effects of dextrose on their food intake.
Topics: Animals; Blood Glucose; Body Weight; Circadian Rhythm; Feeding Behavior; Female; Glucose; Growth; Ra | 1976 |
Runt syndrome induced in the rat by polyinosinic-polycytidylic acid.
Topics: Animals; Animals, Newborn; Body Weight; Cell Division; Erythropoiesis; Graft vs Host Disease; Idoxur | 1975 |
Allergic granulomatous angiitis (Churg-Strauss syndrome).
Topics: Adolescent; Arteritis; Asthma; Blood Cell Count; Body Weight; Drug Therapy, Combination; Eosinophili | 1975 |
Metabolic studies in the pyelonephritic rat.
Topics: Adipose Tissue; Animals; Body Weight; Creatinine; Diet; Disease Models, Animal; Epinephrine; Fatty A | 1975 |
Preliminary studies of somatomedin in vitro and in vivo in rats.
Topics: Aminoisobutyric Acids; Animals; Biological Transport, Active; Body Weight; Cartilage; Chickens; Diap | 1975 |
Influences of long-term cigarette smoke exposure on pharmacokinetics of theophylline, and on liver microsomal enzymes in rats.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Cytochro | 1992 |
Quantitative relationships between cyclic adenosine-3',5'-monophosphate and lipolysis in adipose tissue during the peripartum period.
Topics: Adenosine Deaminase; Adipose Tissue; Animals; Body Weight; Cattle; Cyclic AMP; Eating; Female; Glyce | 1992 |
Assessment of a short-term reproductive and developmental toxicity screen.
Topics: Animals; Body Weight; Boric Acids; Ethylene Glycol; Ethylene Glycols; Female; Male; Mice; Organ Size | 1992 |
Methotrexate treatment of severe asthma in children.
Topics: Adolescent; Albuterol; Asthma; Beclomethasone; Body Height; Body Weight; Child; Child, Preschool; Cr | 1992 |
Somatic development of the infant monkey following in utero exposure to caffeine.
Topics: Animals; Body Weight; Caffeine; Female; Half-Life; Humans; Infant, Newborn; Macaca fascicularis; Mal | 1991 |
A prospective evaluation of elevated serum theophylline concentrations to determine if high concentrations are predictable.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Body Weight; Humans; Lung Diseases, Obstructiv | 1991 |
Lack of a pharmacokinetic interaction between doxapram and theophylline in apnea of prematurity.
Topics: Apnea; Body Weight; Doxapram; Drug Interactions; Female; Gestational Age; Half-Life; Humans; Infant, | 1991 |
The effect of methylxanthines on milk volume and composition, and growth of rat pups.
Topics: Animals; Animals, Newborn; Body Weight; Caffeine; Fatty Acids; Female; Lactation; Milk; Pregnancy; R | 1990 |
Effect of methylxanthines on lactational performance of rats.
Topics: Animals; Animals, Newborn; Body Weight; Caffeine; Drinking; Eating; Female; Lactation; Pregnancy; Ra | 1990 |
Effect of theophylline on calcium metabolism and circulating vitamin D metabolites.
Topics: Animals; Body Weight; Calcifediol; Calcitriol; Calcium; Infusion Pumps; Male; Parathyroid Hormone; R | 1990 |
The effects of age and dietary protein restriction on the pharmacokinetics of theophylline in the rat.
Topics: Aging; Animals; Body Weight; Kwashiorkor; Liver; Male; Oxidation-Reduction; Protein Deficiency; Rats | 1990 |
Effects of perinatal administration of isobutyl methylxanthine (IBMX) on [3H]-DA binding in the forebrain of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding, Competitive; Body Weight; Cyclic AMP; Diencephalon; D | 1986 |
The effect of adenosine and adenosine analogues on methylxanthine-induced hypercalciuria in the rat.
Topics: Adenosine; Animals; Body Weight; Caffeine; Calcium; Diet; Diuresis; Male; Rats; Rats, Inbred Strains | 1989 |
Aspartame and phenylalanine do not enhance theophylline-induced seizures in rats.
Topics: Animals; Aspartame; Body Temperature; Body Weight; Dipeptides; Drug Interactions; Female; Phenylalan | 1989 |
Maturational changes of theophylline pharmacokinetics in preterm infants.
Topics: Age Factors; Body Weight; Gestational Age; Half-Life; Humans; Infant, Newborn; Infant, Premature; Li | 1989 |
Effect of enoxacin on theophylline neurotoxicity.
Topics: Animals; Body Temperature; Body Weight; Chromatography, High Pressure Liquid; Drug Interactions; Eno | 1989 |
Effect of body weight on the volume of distribution of theophylline.
Topics: Adult; Aged; Asthma; Body Weight; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Age | 1988 |
Subchronic toxicity of orally administered (gavage and dosed-feed) theophylline in Fischer 344 rats and B6C3F1 mice.
Topics: Administration, Oral; Animals; Body Weight; Eating; Female; Kidney; Male; Mesenteric Arteries; Mice; | 1988 |
Studies on the short-term toxicity of theophylline in rats and mice.
Topics: Animals; Body Weight; Female; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred F344; Species Spe | 1988 |
Adverse pregnancy outcome in the monkey (Macaca fascicularis) after chronic caffeine exposure.
Topics: Abortion, Veterinary; Animals; Birth Weight; Body Weight; Caffeine; Female; Fetal Death; Macaca fasc | 1988 |
Quantitative parameters of body composition and theophylline disposition.
Topics: Adipose Tissue; Adult; Body Composition; Body Weight; Humans; Male; Osmolar Concentration; Theophyll | 1988 |
Determinants of free theophylline clearance in asthma.
Topics: Adult; Aged; Asthma; Body Weight; Female; Humans; Male; Middle Aged; Theophylline; Thyroid Hormones | 1987 |
Pharmacokinetics of oral theophylline in Thai asthmatic children.
Topics: Administration, Oral; Adolescent; Asthma; Body Weight; Child; Ethnicity; Half-Life; Humans; Solution | 1987 |
Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture.
Topics: Animals; Body Temperature Regulation; Body Weight; Caffeine; Drug Therapy, Combination; Eating; Ener | 1987 |
Effects of maternal caffeine ingestion on the perinatal cerebrum.
Topics: Animals; Body Weight; Brain; Caffeine; Female; Fetus; Maternal-Fetal Exchange; Organ Size; Placenta; | 1987 |
Effect of dietary caffeine and theophylline on urinary calcium excretion in the adult rat.
Topics: Animals; Body Weight; Caffeine; Calcium; Diet; Dose-Response Relationship, Drug; Indomethacin; Male; | 1987 |
Theophylline loading dose in obese patients.
Topics: Adult; Aminophylline; Body Weight; Female; Humans; Hypotension; Obesity; Theophylline | 1987 |
Effect of theophylline on the initiation phase of postischemic acute renal failure in rats.
Topics: Acute Kidney Injury; Adenosine; Animals; Blood Pressure; Body Weight; Glomerular Filtration Rate; In | 1986 |
[Guidelines for determination of the optimum dosage of E-0686. A new sustained-release preparation of theophylline].
Topics: Adolescent; Adult; Age Factors; Aged; Asthma; Body Weight; Child; Child, Preschool; Delayed-Action P | 1986 |
Theophylline clearance during pregnancy.
Topics: Adolescent; Adult; Asthma; Body Weight; Female; Humans; Kinetics; Postpartum Period; Pregnancy; Preg | 1986 |
Demeclocycline-induced natriuresis and renal insufficiency: in vivo and in vitro studies.
Topics: Administration, Oral; Aldosterone; Animals; Anura; Biological Transport; Blood Urea Nitrogen; Body W | 1985 |
Factors influencing theophylline disposition in 179 newborns.
Topics: Apgar Score; Asphyxia Neonatorum; Body Weight; Female; Gestational Age; Humans; Infant, Newborn; Inf | 1986 |
The fate of chronically consumed caffeine in the monkey (Macaca fascicularis).
Topics: Animals; Biotransformation; Body Weight; Caffeine; Chromatography, High Pressure Liquid; Eating; Fem | 1985 |
Influence of body fat on the volume of distribution of theophylline.
Topics: Adipose Tissue; Adolescent; Adult; Aged; Aminophylline; Body Weight; Bronchial Spasm; Female; Humans | 1985 |
Influence of the mutation "diabetes" on insulin release and islet morphology in mice of different genetic backgrounds.
Topics: Animals; Benzenesulfonates; Blood Glucose; Body Weight; Diabetes Mellitus; Glucose; Hyperglycemia; I | 1974 |
Catecholamines and metabolism of human adipose tissue. I. Comparison between in vitro effects of noradrenaline, adrenaline and theophylline on lipolysis in omental adipose tissue.
Topics: Adipose Tissue; Adolescent; Adult; Age Factors; Aged; Body Weight; Cholecystectomy; Cyclic AMP; Epin | 1969 |
Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic mice.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Body Weight; Disease Models, Animal; Epididymi | 1970 |
Mobilization of fatty acids in genetically obese rats.
Topics: Adipose Tissue; Animals; Body Weight; Butyrates; Cyclic AMP; Epinephrine; Fasting; Fatty Acids, None | 1970 |
Insulin release from human fetal pancreas in vitro.
Topics: Arginine; Barium; Body Weight; Cyclic AMP; Female; Fetus; Gestational Age; Glucagon; Glucose; Humans | 1971 |
Lipolysis and glucose tolerance in obese subjects during prolonged starvation.
Topics: Adipose Tissue; Adult; Blood Glucose; Body Height; Body Weight; Culture Techniques; Cyclic AMP; Diet | 1971 |
Effects of norepinephrine, theophylline and dibutyryl cyclic AMP on in vitro lipolysis of human adipose tissue in obesity.
Topics: Adipose Tissue; Adult; Aged; Body Weight; Cyclic AMP; Fatty Acids; Fatty Acids, Nonesterified; Femal | 1972 |
Lipolysis in the adipose tissue of mice made obese with goldthioglucose.
Topics: Adipose Tissue; Animals; Body Weight; Butyrates; Cell Count; Cyclic AMP; Epinephrine; Glucose; Gold; | 1972 |
Noradrenaline-induced lipolysis in subcutaneous adipose tissue from hypothyroid subjects. The relation of noradrenaline response to the degree and duration of the disease.
Topics: Adipose Tissue; Adult; Age Factors; Aged; Body Weight; Cholesterol; Cyclic AMP; Female; Glycerol; Hu | 1972 |
Lipolysis and adenosine 3',5'-cyclic monophosphate in adipose tissue of the New Zealand obese mouse.
Topics: Adipose Tissue; Age Factors; Animals; Body Weight; Cyclic AMP; Glycerol; Isoproterenol; Lipid Metabo | 1973 |
The inhibitory effects of theophylline feeding on gluconeogenic enzymes in rat liver.
Topics: Adaptation, Physiological; Adipose Tissue; Administration, Oral; Animals; Body Weight; Depression, C | 1972 |
Cell size and lipolysis by human subcutaneous adipose tissue.
Topics: Adipose Tissue; Adolescent; Adult; Biopsy; Body Weight; Cholecystectomy; Cyclic AMP; Female; Glycero | 1973 |
Analogs of alpha-tocopherol as inhibitors of cyclic-AMP and cyclic-GMP phosphodiesterases and effects of alpha-tocopherol deficiency on cyclic AMP-controlled metabolism.
Topics: Animals; Body Weight; Cattle; Cyclic AMP; Cyclic GMP; Glycogen; Kinetics; L-Serine Dehydratase; Live | 1974 |
Lipolysis in genetically obese and diabetes-prone mice.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Blood Glucose; Body Weight; Butyrates; Cyclic AMP; Dieta | 1970 |
Fetal hypoproteinemia associated with generalized edema caused by administration of methyl xanthines to the rat during late pregnancy.
Topics: Animals; Blood Proteins; Body Water; Body Weight; Caffeine; Edema; Female; Fetal Diseases; Fetus; Ge | 1973 |
[Effects of the partial removal of the brown fat and of theophylline on the calorigenic response to noradrenaline in the rat adapted to cold].
Topics: Adaptation, Physiological; Adipose Tissue, Brown; Animals; Body Temperature; Body Temperature Regula | 1974 |
Effect of oral prednisone on the measurement of plasma steroid concentrations by the competitive protein-binding radioassay.
Topics: Asthma; Binding, Competitive; Body Weight; Child; Fluorometry; Humans; Hydrocortisone; Methylprednis | 1974 |
Human foetal pancreatic insulin secretion in response to ionic and other stimuli.
Topics: Adenine Nucleotides; Barium; Body Weight; Chlorides; Fetus; Gestational Age; Glucagon; Glycogen; Hum | 1971 |
Effect of dietary theophylline on pyruvate metabolism and respiratory activities in liver mitochondria. 1.
Topics: Acetoacetates; Adipose Tissue; Animals; Bicarbonates; Body Weight; Carbon Isotopes; Carnitine; Diet; | 1972 |
Respiratory-renal adjustments in chronic hypercapnia in man. Extracellular bicarbonate concentration and the regulation of ventilation.
Topics: Adult; Ammonia; Ammonium Chloride; Bicarbonates; Body Weight; Carbon Dioxide; Chlorides; Chronic Dis | 1971 |
Lipolysis of human adipose tissue cells: influence of donor factors.
Topics: Adipose Tissue; Adult; Age Factors; Aged; Anesthetics; Animals; Basal Metabolism; Body Weight; Chole | 1971 |
[Observations and experiences with Theo-Caradrin].
Topics: Body Weight; Diuresis; Geriatrics; Heart Diseases; Heart Failure; Humans; Middle Aged; Phytotherapy; | 1967 |
Effects of high-carbohydrate diets on lipid and carbohydrate metabolism in the rat.
Topics: Animals; Blood Glucose; Blood Protein Electrophoresis; Body Weight; Carbohydrate Metabolism; Cholest | 1969 |