theophylline has been researched along with B16 Melanoma in 21 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cutaneous melanoma is the most aggressive skin cancer, derived from neoplastic transformation of melanocytes." | 5.51 | Theophylline induces differentiation and modulates cytoskeleton dynamics and cytokines secretion in human melanoma-initiating cells. ( Cordella, M; D'Arcangelo, D; Eramo, A; Facchiano, A; Facchiano, F; Lintas, C; Mueller, S; Rossi, S; Senatore, C; Tabolacci, C; Valitutti, S, 2019) |
| "Treatment with theophylline, in contrast, markedly elevated the sialic acid content, which was accompanied by dramatic increments in tyrosinase activity and pigmentation as well as a slight increase in adhesiveness." | 5.28 | Cellular sialic acid level and phenotypic expression in B16 melanoma cells: comparison of spontaneous variations and bromodeoxyuridine- and theophylline-induced changes. ( Kinoshita, Y; Sato, S; Takeuchi, T, 1989) |
| " ex Baker (Zingiberaceae) has shown inhibitory effects against melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells (IC50 = 9." | 3.83 | Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora. ( Chaipech, S; Hayakawa, T; Katsuyama, Y; Matsumoto, T; Miyake, S; Morikawa, T; Muraoka, O; Ninomiya, K; Pongpiriyadacha, Y; Tsuboyama, A, 2016) |
| "The methanolic extract from the flower buds of Cananga odorata showed an inhibitory effect on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells." | 3.80 | Lignan dicarboxylates and terpenoids from the flower buds of Cananga odorata and their inhibitory effects on melanogenesis. ( Fujimoto, K; Matsuda, H; Matsumoto, T; Nakamura, S; Nakashima, S; Ogawa, K; Ohta, T; Yoshikawa, M, 2014) |
| " Treatment of B16 melanoma cells with either theophylline, MSH, or its superpotent analog [Ahx4, DPhe7]MSH promotes a larger induction of tyrosine hydroxylase than of dopa oxidase activity in whole cell extracts." | 3.68 | Tyrosinase isoenzymes in mammalian melanocytes. 2. Differential activation by alpha-melanocyte-stimulating hormone. ( Garcia-Borron, JC; Jimenez-Cervantes, C; Lozano, JA; Solano, F; Valverde, P, 1993) |
| "The differentiation-inducing activity of doxorubicin on B16 melanoma cells grown in vitro was compared with that of other known differentiation inducers, such as theophylline, retinoic acid, and melanocyte-stimulating hormone (MSH)." | 3.68 | Comparative studies on the effects of doxorubicin and differentiation inducing agents on B16 melanoma cells. ( Bottiroli, G; Colombo, A; Croce, AC; Mariani, M; Prosperi, E; Supino, R, 1992) |
| " Treatment of B16 melanoma cells with theophylline or alpha MSH mediates a larger induction of tyrosine hydroxylase than of dopa oxidase activity in total cell extracts, and in the melanosomal and microsomal fractions." | 3.68 | Melanocyte stimulating hormone activation of tyrosinase in B16 mouse melanoma cells. Evidence for a differential induction of two distinct isoenzymes. ( García-Borrón, JC; Lozano, JA; Martínez-Liarte, JH; Solano, F; Valverde, P, 1992) |
| "Cutaneous melanoma is the most aggressive skin cancer, derived from neoplastic transformation of melanocytes." | 1.51 | Theophylline induces differentiation and modulates cytoskeleton dynamics and cytokines secretion in human melanoma-initiating cells. ( Cordella, M; D'Arcangelo, D; Eramo, A; Facchiano, A; Facchiano, F; Lintas, C; Mueller, S; Rossi, S; Senatore, C; Tabolacci, C; Valitutti, S, 2019) |
| " In this study, we established a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the microphthalmia-associated transcription factor (MITF), tyrosinase (Tyr) and dopachrome tautomerase (Dct) genes in MeWo human melanoma cells." | 1.42 | Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells. ( Chen, CY; Chiu, YW; Lin, CC; Lin, YJ; Yang, CH, 2015) |
| "Theophylline-treated B16-F10 melanoma cells show a lower experimental metastatic potential in vivo." | 1.31 | Theophylline administration markedly reduces hepatic and pulmonary implantation of B16-F10 melanoma cells in mice. ( Abbruzzese, A; Beninati, S; Caraglia, M; Facchiano, F; Lentini, A; Vidal-Vanaclocha, F, 2000) |
| "Theophylline- and caffeine-treated B16-F10 cells exhibited low adhesion to laminin/collagen type IV and reduced invasion through Matrigel in an in vitro assay." | 1.30 | Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation. ( Abbruzzese, A; Autuori-Pezzoli, V; Beninati, S; Cardinali, M; Kleinman, HK; Lentini, A; Mattioli, P; Nicolini, L; Pietrini, A, 1998) |
| "Treatment with theophylline, in contrast, markedly elevated the sialic acid content, which was accompanied by dramatic increments in tyrosinase activity and pigmentation as well as a slight increase in adhesiveness." | 1.28 | Cellular sialic acid level and phenotypic expression in B16 melanoma cells: comparison of spontaneous variations and bromodeoxyuridine- and theophylline-induced changes. ( Kinoshita, Y; Sato, S; Takeuchi, T, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamauchi, K | 1 |
| Mitsunaga, T | 1 |
| Batubara, I | 1 |
| Cordella, M | 1 |
| Tabolacci, C | 3 |
| Senatore, C | 1 |
| Rossi, S | 1 |
| Mueller, S | 1 |
| Lintas, C | 1 |
| Eramo, A | 1 |
| D'Arcangelo, D | 1 |
| Valitutti, S | 1 |
| Facchiano, A | 1 |
| Facchiano, F | 2 |
| Manosroi, A | 1 |
| Chaikul, P | 1 |
| Abe, M | 1 |
| Manosroi, W | 1 |
| Manosroi, J | 1 |
| Matsumoto, T | 2 |
| Nakamura, S | 1 |
| Nakashima, S | 1 |
| Fujimoto, K | 1 |
| Yoshikawa, M | 1 |
| Ohta, T | 1 |
| Ogawa, K | 1 |
| Matsuda, H | 1 |
| Lin, CC | 1 |
| Yang, CH | 1 |
| Lin, YJ | 1 |
| Chiu, YW | 1 |
| Chen, CY | 1 |
| Ninomiya, K | 1 |
| Chaipech, S | 1 |
| Miyake, S | 1 |
| Katsuyama, Y | 1 |
| Tsuboyama, A | 1 |
| Pongpiriyadacha, Y | 1 |
| Hayakawa, T | 1 |
| Muraoka, O | 1 |
| Morikawa, T | 1 |
| Lentini, A | 4 |
| Mattioli, P | 3 |
| Provenzano, B | 2 |
| Beninati, S | 5 |
| Nardi, A | 1 |
| Miller, N | 1 |
| Vile, RG | 1 |
| Hart, IR | 1 |
| Prezioso, JA | 1 |
| Hearing, VJ | 1 |
| Muller, J | 1 |
| Urabe, K | 1 |
| Wang, N | 1 |
| Gorelik, E | 1 |
| Valverde, P | 2 |
| Garcia-Borron, JC | 2 |
| Jimenez-Cervantes, C | 1 |
| Solano, F | 2 |
| Lozano, JA | 2 |
| Abbruzzese, A | 3 |
| Cardinali, M | 2 |
| Kleinman, HK | 1 |
| Autuori-Pezzoli, V | 1 |
| Nicolini, L | 1 |
| Pietrini, A | 1 |
| Vidal-Vanaclocha, F | 1 |
| Caraglia, M | 1 |
| Gude, RP | 2 |
| Jadhav, MG | 1 |
| Rao, SG | 1 |
| Jagtap, AG | 1 |
| Menon, LG | 1 |
| Ingle, AD | 1 |
| Supino, R | 1 |
| Mariani, M | 1 |
| Colombo, A | 1 |
| Prosperi, E | 1 |
| Croce, AC | 1 |
| Bottiroli, G | 1 |
| Martínez-Liarte, JH | 1 |
| Kwon, BS | 1 |
| Halaban, R | 1 |
| Kim, GS | 1 |
| Usack, L | 1 |
| Pomerantz, S | 1 |
| Haq, AK | 1 |
| Kinoshita, Y | 1 |
| Sato, S | 1 |
| Takeuchi, T | 1 |
| Fuller, BB | 1 |
21 other studies available for theophylline and B16 Melanoma
| Article | Year |
|---|---|
Synthesis of quercetin glycosides and their melanogenesis stimulatory activity in B16 melanoma cells.
Topics: Animals; Carbohydrate Sequence; Cell Line, Tumor; Cellobiose; Chemistry Techniques, Synthetic; Dose- | 2014 |
Theophylline induces differentiation and modulates cytoskeleton dynamics and cytokines secretion in human melanoma-initiating cells.
Topics: Apoptosis; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cytokines; Cyt | 2019 |
Melanogenesis of methyl myristate loaded niosomes in B16F10 melanoma cells.
Topics: Animals; Cell Death; Cell Survival; Fibroblasts; Humans; Intramolecular Oxidoreductases; Liposomes; | 2013 |
Lignan dicarboxylates and terpenoids from the flower buds of Cananga odorata and their inhibitory effects on melanogenesis.
Topics: Algorithms; Animals; Antineoplastic Agents; Cananga; Dicarboxylic Acids; Drug Screening Assays, Anti | 2014 |
Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells.
Topics: Acetophenones; Arbutin; Benzopyrans; Cell Line, Tumor; Drug Evaluation, Preclinical; Enzyme Inductio | 2015 |
Simultaneous quantitative analysis of 12 methoxyflavones with melanogenesis inhibitory activity from the rhizomes of Kaempferia parviflora.
Topics: Animals; Chromatography, High Pressure Liquid; Flavones; Intramolecular Oxidoreductases; Melanins; M | 2016 |
Antitumor activity of theophylline in combination with Paclitaxel: a preclinical study on melanoma experimental lung metastasis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Pro | 2010 |
Preclinical evaluation of the antineoplastic efficacy of 7-(2-hydroxyethyl)theophylline on melanoma cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Drug Screening | 2012 |
Effects of modulators of tyrosinase activity on expression of murine interleukin-2 cDNA driven by the tyrosinase promoter.
Topics: 3T3 Cells; Aminophylline; Animals; Consensus Sequence; DNA, Complementary; Dose-Response Relationshi | 1995 |
Impairment of the melanogenic pathway in B16 melanoma cells transfected with class I H-2 genes.
Topics: alpha-MSH; Animals; Colforsin; Cyclic AMP; Genes, MHC Class I; H-2 Antigens; Melanins; Melanoma, Exp | 1995 |
Tyrosinase isoenzymes in mammalian melanocytes. 2. Differential activation by alpha-melanocyte-stimulating hormone.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Induction; Isoenzymes; Kinet | 1993 |
Differences in the post-translational modification of proteins by polyamines between weakly and highly metastatic B16 melanoma cells.
Topics: Animals; Melanins; Melanoma, Experimental; Mice; Neoplasm Metastasis; Neoplasm Proteins; Putrescine; | 1993 |
Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation.
Topics: Animals; Caffeine; Cell Adhesion; Cell Division; Collagen; Laminin; Lung Neoplasms; Male; Melanins; | 1998 |
Theophylline administration markedly reduces hepatic and pulmonary implantation of B16-F10 melanoma cells in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Liver; Liver Neoplasms; Lung; Lung Neoplasms; Male; Melan | 2000 |
Effects of niosomal cisplatin and combination of the same with theophylline and with activated macrophages in murine B16F10 melanoma model.
Topics: Animals; Antineoplastic Agents; Body Weight; Cisplatin; Combined Modality Therapy; Female; Leukocyte | 2002 |
Tumor regression of B16F10 melanoma in vivo by prevention of neovascularization: study on theophylline.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Mel | 2002 |
Comparative studies on the effects of doxorubicin and differentiation inducing agents on B16 melanoma cells.
Topics: alpha-MSH; Animals; Cell Cycle; Cell Differentiation; Cell Survival; DNA, Neoplasm; Doxorubicin; Ext | 1992 |
Melanocyte stimulating hormone activation of tyrosinase in B16 mouse melanoma cells. Evidence for a differential induction of two distinct isoenzymes.
Topics: Animals; Enzyme Activation; Melanocyte-Stimulating Hormones; Melanocytes; Melanoma, Experimental; Mi | 1992 |
A melanocyte-specific complementary DNA clone whose expression is inducible by melanotropin and isobutylmethyl xanthine.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antibodies, Monoclonal; Catechol Oxidase; DNA; Gene Expression | 1987 |
Cellular sialic acid level and phenotypic expression in B16 melanoma cells: comparison of spontaneous variations and bromodeoxyuridine- and theophylline-induced changes.
Topics: Animals; Bromodeoxyuridine; Cell Adhesion; Melanoma, Experimental; Mice; N-Acetylneuraminic Acid; Ph | 1989 |
Inhibition of tyrosinase activity and protein synthesis in melanoma cells by calcium ionophore A23187.
Topics: Alprostadil; Animals; Bucladesine; Calcimycin; Catechol Oxidase; Cell Line; Cyclic AMP; Melanocyte-S | 1987 |