theophylline has been researched along with Asthma, Bronchial in 2615 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the 1990s, numerous double-blind, randomized, placebo-controlled trials revealed that theophylline therapy offered no benefit to inhaled beta2 agonists and systemic corticosteroids in the treatment of patients hospitalized for asthma exacerbations." | 10.20 | Reassessment of theophylline use for severe asthma exacerbation: is it justified in critically ill hospitalized patients? ( Nguyen, WT; Redmond, AM; Self, TH, 2002) |
| "We describe a 25-year-old patient with severe bronchial asthma, which was difficult to treat with oral theophylline." | 10.17 | Severe bronchial asthma improved on bamifylline. Case report and review. ( Bijl, D; Speelberg, B, 1994) |
| "Theophylline and beta 2-mimetic agents have long been used concomitantly in the treatment of asthma, but divergent opinions are lingering on concerning the safety and effectiveness of this combination in both chronic and acute asthma." | 10.16 | [Combination of theophylline and beta-adrenergic agonists in the treatment of asthma: efficacy and tolerance. Review of the literature]. ( Iung, B; Laaban, JP; Rochemaure, J, 1989) |
| "One of the important modes of action of theophylline in asthma and chronic obstructive airway disease may be the inhibition of airway inflammation." | 10.16 | The effects of theophylline on airway inflammation. ( Pauwels, R, 1987) |
| "We assessed the pulmonary function in asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide in a pilot group." | 9.19 | Pulmonary function assessment in mild to moderate persistent asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide: a randomized controlled study. ( Ilango, K; Nageswari, AD; Rajanandh, MG, 2014) |
| "To explore the therapeutic efficacies of inhaled corticosteroids (ICS) plus low-dose theophylline for moderate bronchial asthma." | 9.17 | [Clinical efficacies of inhaled corticosteroids plus theophylline in the treatment of bronchial asthma]. ( Chen, ZC; Ding, JJ; Feng, KQ; Lin, XH; Qian, HY; Wang, J, 2013) |
| "To compare the efficacy of theophylline plus salmeterol/fluticasone propionate combination product (SFC) with SFC plus placebo in asthmatic patients." | 9.17 | Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma. ( Ding, X; Hu, S; Huang, Y; Liu, M; Nie, H; Zhang, G, 2013) |
| "Whether the additive effects of the tulobuterol patch (TP), the world's first transdermal beta2-agonist preparation, are useful in asthma patients receiving inhaled corticosteroid (ICS) is unclear." | 9.14 | Effects of the addition of Beta2-agonist tulobuterol patches to inhaled corticosteroid in patients with asthma. ( Haruta, Y; Hozawa, S; Terada, M; Yamakido, M, 2009) |
| "To compare the efficacy and safety of the salmeterol/fluticasone propionate combination product with concurrent sustained release theophylline plus fluticasone propionate in adult Japanese patients with persistent asthma." | 9.13 | Comparison of salmeterol/fluticasone propionate (FP) combination with FP+sustained release theophylline in moderate asthma patients. ( Adachi, M; Aizawa, H; Ishihara, K; Nakashima, M; Ohta, K; Sano, Y; Taniguchi, H, 2008) |
| " Therefore, a 12-week randomized double-blind placebo-controlled clinical study was conducted to investigate the efficacy of a plant-based formulation (DCBT4567-Astha-15) in comparison with oral salbutamol, salbutamol + theophylline and a matching placebo in patients with reversible asthma." | 9.12 | Plant-based formulation for bronchial asthma: a controlled clinical trial to compare its efficacy with oral salbutamol and theophylline. ( Deivanayagam, CN; Krishnarajasekar, OR; Lakshmisubramanian, S; Murali, PM; Nalini, K; Perumal, T; Rajasekaran, S, 2006) |
| "To observe the role of theophylline in relieving airway symptoms and inflammation in patients with mild asthma." | 9.12 | [Clinical efficacy of low-dose oral theophylline for treating mild asthma]. ( Huang, SD; Pan, QH; Tian, LQ; Yang, J; Zhang, SY, 2006) |
| "The purpose of this study was to investigate the efficacy and safety of salmeterol combined with high-dose ICSs plus theophylline in severe asthma." | 9.12 | Effects of salmeterol in patients with persistent asthma receiving inhaled corticosteroid plus theophylline. ( Aizawa, H; Fukuyama, S; Inoue, H; Kanaya, A; Komori, M; Matsumoto, K; Matsumoto, T; Matsumura, M; Moriwaki, A; Nakanishi, Y; Nakano, T; Tsuda, M; Yoshida, M, 2007) |
| "We conducted a randomized, double-masked, placebo-controlled trial in 489 participants with poorly controlled asthma randomly assigned to placebo, theophylline (300 mg/d), or montelukast (10 mg/d)." | 9.12 | Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. ( , 2007) |
| "The results indicate that montelukast added to low-dose ICS is an effective and safe option for the treatment of asthma in children." | 9.12 | A randomized open-label comparative study of montelukast versus theophylline added to inhaled corticosteroid in asthmatic children. ( Katsunuma, T; Kondo, N; Morikawa, A; Odajima, Y, 2006) |
| "Asthmatic patients receiving montelukast and, to some extent, low-dose theophylline have lower levels of CVD-associated inflammatory biomarkers and lipid levels." | 9.12 | The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. ( Allayee, H; Conti, DV; Hartiala, J; Irvin, CG; Lee, W; Lima, JJ; Mehrabian, M, 2007) |
| "In a study comparing low-dose theophylline to montelukast in poorly controlled asthmatics, 285 subjects consented to be screened for alpha-1 antitrypsin deficiency." | 9.12 | Prevalence of alpha-1 antitrypsin deficiency in poorly controlled asthma--results from the ALA-ACRC low-dose theophylline trial. ( Brantly, ML; Eden, E; Holbrook, JT; Turino, GM; Wise, RA, 2007) |
| "This study was undertaken to compare the efficacy of inhaled beclomethasone dipropionate to oral theophylline for the prevention of asthma exacerbation(s) requiring medical intervention." | 9.11 | Randomized trial of inhaled beclomethasone dipropionate versus theophylline for moderate asthma during pregnancy. ( Caritis, SN; Conway, DL; Dombrowski, MP; Hauth, JC; Landon, M; Leveno, KJ; Lindheimer, M; Mabie, W; McNellis, D; Meis, P; Miodovnik, M; Newman, RB; O'Sullivan, MJ; Schatz, M; Thom, EA; Varner, MW; Wapner, RJ; Wise, R, 2004) |
| "The effects of high-dose fluticasone propionate therapy on dynamic cortisol stimulation in severe asthma are unknown." | 9.11 | Effects of high-dose inhaled fluticasone propionate on the hypothalamic-pituitary-adrenal axis in asthmatic patients with severely impaired lung function. ( Bates, CE; Cowan, LM; Currie, GP; Lee, DK; Lipworth, BJ; McFarlane, LC, 2004) |
| "The present study was designed to evaluate the efficacy and safety of intravenously administered theophylline (IAT) for the treatment of an acute exacerbation of bronchial asthma." | 9.11 | Efficacy and safety of intravenous theophylline administration for treatment of mild acute exacerbation of bronchial asthma. ( Inoue, H; Kobayashi, H; Pian, HD; Tanifuji, Y; Yamauchi, K; Yoshida, T, 2005) |
| "Twenty-four patients with mild-to-moderate asthma were studied using a randomized crossover design with the following three treatment blocks: (1) beclomethasone, 100 microg/d, alone for the first 2 weeks followed by 400 microg/d alone for the next 2 weeks; (2) beclomethasone, 100 microg/d, followed by 400 microg/d, with the addition of zafirlukast, 20 mg bid; (3) beclomethasone, 100 microg/d, followed by 400 microg/d, with the addition of theophylline, 200 to 300 mg bid." | 9.10 | Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma. ( Dempsey, OJ; Fowler, SJ; Kennedy, G; Lipworth, BJ; Wilson, A, 2002) |
| "We analyzed the effect of genetic polymorphisms in the 5'-flanking region to the first intron of the CYP1A2 gene on theophylline metabolism in 75 Japanese patients with asthma and 159 healthy Japanese volunteers." | 9.10 | Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma. ( Kawano, T; Kinoshita, M; Kohno, S; Matsuse, H; Mitsuta-Izaki, K; Obase, Y; Saeki, S; Shimoda, T; Tomari, SY, 2003) |
| "The purpose of this study was to compare the efficacy and safety of the inhaled budesonide, sustained-release theophylline and montelukast, a leukotriene receptor antagonist, in patients with mild persistent asthma." | 9.10 | Comparative efficacy of once-daily therapy with inhaled corticosteroid, leukotriene antagonist or sustained-release theophylline in patients with mild persistent asthma. ( Eren, A; Sipit, T; Taci, N; Yurdakul, AS, 2003) |
| " Patients kept records of peak flow meter (PFM) measurements, asthma attack rate and beta-2-agonist use (albuterol)." | 9.10 | Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma -- a double-blind randomized placebo-controlled multicentre clinical trial. ( Chervinsky, P; Goldstein, MF, 2002) |
| "A sustained-release formulation of theophylline with an innovative release mechanism was evaluated in adult asthmatics." | 9.09 | Comparative pharmacodynamic-pharmacokinetic correlation of oral sustained-release theophylline formulation in adult asthmatics. ( Devarajan, PV; Parmar, DV; Sule, PN, 1999) |
| "Thus, in the theophylline-administered group, slow-release theophylline, Theolong, was effective in treating asthma, with anti-inflammatory effects on inflammatory cells besides its bronchodilator action." | 9.09 | Suppression of airway inflammation by theophylline in adult bronchial asthma. ( Doi, M; Hirose, M; Horiguchi, T; Imazu, M; Kasahara, J; Miyazaki, J; Sasaki, Y; Shiga, M; Tachikawa, S, 1999) |
| "To compare the efficacy, safety, and effects on sleep quality of salmeterol and extended-release theophylline in patients with nocturnal asthma." | 9.09 | Salmeterol vs theophylline: sleep and efficacy outcomes in patients with nocturnal asthma. ( Mende, CN; Petrocella, VJ; Rickard, KA; Wiegand, L; Yancey, SW; Zaidel, G; Zwillich, CW, 1999) |
| "Fluticasone propionate 880 microg/day improved lung function and quality of life in adolescents with moderate-to-severe asthma when compared with flunisolide 1500 microg/day." | 9.09 | Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma. ( Eid, N; Goldsmith, LJ; Howell, L; Sheikh, S, 1999) |
| "In order to evaluate the effects of theophylline on airway inflammation, we investigated 48 subjects with mild and moderate asthma." | 9.09 | Once-daily theophylline reduces serum eosinophil cationic protein and eosinophil levels in induced sputum of asthmatics. ( Aizawa, H; Hara, N; Inoue, H; Iwanaga, T; Matsumoto, K; Takahashi, N; Takata, S; Yoshida, M, 2000) |
| "The authors investigated whether theophylline metabolism is decreased in asthmatic patients and what condition may be related to its reduction." | 9.09 | Higher incidence of elevated body temperature or increased C-reactive protein level in asthmatic children showing transient reduction of theophylline metabolism. ( Akimoto, Y; Kobayashi, S; Koitabashi, Y; Matuda, T; Miyoshi, T; Okano, Y; Tateishi, T; Yamaguchi, A, 2000) |
| "The precise mechanism of action of theophylline in asthma is not fully understood but recent data have drawn attention to its potential anti-inflammatory effect." | 9.09 | Effect of a 4-week treatment with theophylline on sputum eosinophilia and sputum eosinophil chemotactic activity in steroid-naive asthmatics. ( Bettiol, J; Cataldo, D; Henquet, M; Louis, R; Radermecker, M; Sele, J, 2000) |
| "Theophylline is widely used in the treatment of asthma, and there is evidence that theophylline has anti-inflammatory or immunomodulatory effects." | 9.09 | Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice. ( Barnes, PJ; Chung, KF; Gordon, D; Jatakanon, A; Lim, S; Macdonald, C, 2000) |
| "Theophylline is well-established in the management of asthma, and there is some evidence of an antiinflammatory effect in asthma." | 9.09 | Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. ( Adcock, I; Barnes, PJ; Caramori, G; Carramori, G; Chung, KF; Jatakanon, A; Keller, A; Lim, S; Oliver, B; Tomita, K, 2001) |
| "To investigate whether low dose theophylline has an anti-inflammatory effect in asthma." | 9.09 | Effect of theophylline on airway inflammation in asthma. ( Li, QQ; Tu, HY; Yang, J, 2001) |
| "The aim of present study was to evaluate clinical, functional, and anti-inflammatory effects of inhaled budesonide and oral theophylline treatments in patients with mild to moderate asthma." | 9.09 | Efficacy of inhaled budesonide and oral theophylline in asthmatic subjects. ( Akkaya, E; Baran, R; Ece, F; Erkan, F; Morali, T; Yilmaz, A, 2001) |
| "We studied the efficacy of theophylline chronotherapy for nocturnal asthma using the changes of the circadian rhythms in peak expiratory flow rate (PEF)." | 9.09 | Theophylline chronotherapy of nocturnal asthma using bathyphase of circadian rhythm in peak expiratory flow rate. ( Burioka, N; Igishi, T; Miyata, M; Sako, T; Shimizu, E; Suyama, H; Tomita, K, 2001) |
| "The purpose of this study was to determine whether the addition of extended-release theophylline to the daily treatment regimen of inhaled beta 2-agonist users would result in decreased use of beta 2-agonist while maintaining similar efficacy for treatment of asthma." | 9.08 | Efficacy of once daily extended-release theophylline in decreasing the use of inhaled beta 2-agonists in stable, mild-to-moderate asthma patients. ( Cefali, EA; Dockhorn, RJ; Edwards, TB; Fiddes, RA; Grossman, J; Hassanein, RS; Menendez, R; Southern, DL; Wagner, DE, 1995) |
| "In 61 patients with nocturnal asthma, the effects of budesonide, an inhaled steroid (Pulmicort; 200 micrograms twice daily), long-acting theophylline (Theodur; 200 mg twice daily), and their combination were compared." | 9.08 | A double-blind comparison of inhaled budesonide, long-acting theophylline, and their combination in treatment of nocturnal asthma. ( Permpikul, C; Suthamsmai, T; Wong, E; Youngchaiyud, P, 1995) |
| "In order to assess whether treatment with oral slow-release theophylline prevents early (EAR) and/or late (LAR) airway responses to allergen, we treated six asthmatic subjects with either placebo or oral theophylline (350 mg b." | 9.08 | Oral slow-release theophylline does not prevent early and late asthmatic response to allergen in sensitized subjects. ( Bacci, E; Bancalari, L; Carrara, M; Dente, FL; Di Franco, A; Giannini, D; Giuntini, C; Paggiaro, PL; Vagaggini, B, 1995) |
| "Theophylline is the most widely used anti-asthma drug worldwide and is classified as a bronchodilator, although there is increasing evidence that it may have immunomodulatory effects." | 9.08 | Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy. ( Barnes, PJ; Chung, KF; Dominguez, M; Kidney, J; Rose, M; Taylor, PM, 1995) |
| "We evaluated this potential effect of theophylline in eight patients with nocturnal asthma." | 9.08 | Theophylline: potential antiinflammatory effects in nocturnal asthma. ( Kraft, M; Martin, RJ; Torvik, JA; Trudeau, JB; Wenzel, SE, 1996) |
| "Theophylline has been shown by several investigators to attenuate the late asthmatic response (LAR) to inhaled allergen, suggesting that it has anti-inflammatory or immunomodulatory properties." | 9.08 | Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics. ( Costello, J; Jaffar, ZH; Page, C; Sullivan, P, 1996) |
| " Twenty seven patients (20 to 64 years) with acute asthma attack were given aminophylline intravenously to obtain a theophylline concentration between 10 and 20 micrograms/ml." | 9.08 | Significance of the therapeutic range of serum theophylline concentration in the treatment of an attack of bronchial asthma. ( Murata, M; Nagasawa, K; Nakahara, Y; Ohtsu, F; Suzuki, T, 1996) |
| "The study was designed to determine whether theophylline would inhibit the late asthmatic response by reducing neutrophil activation and subsequent superoxide production." | 9.08 | Theophylline's effect on neutrophil function and the late asthmatic response. ( Borish, L; Kraft, M; Martin, RJ; Pak, J, 1996) |
| "To determine whether controlled-release theophylline inhibits the development of airway obstruction and/or airway hyperresponsiveness early in the morning, we examined 18 subjects reporting recurrent nocturnal asthma." | 9.08 | Controlled-release theophylline inhibits early morning airway obstruction and hyperresponsiveness in asthmatic subjects. ( Boschetto, P; Crescioli, S; Dal Carobbo, A; Fabbri, LM; Hurst, TS; Maestrelli, P; Parise, G; Santagada, T; Steinijans, VW, 1996) |
| "The inhaled corticosteroid, fluticasone propionate, was compared with the oral bronchodilator theophylline in the maintenance treatment of asthma." | 9.08 | Fluticasone propionate compared with theophylline for mild-to-moderate asthma. ( Baker, KA; Galant, SP; Kellerman, DJ; Lawrence, M; Meltzer, EO; Tomasko, M, 1996) |
| "To examine the effects of once-daily, sustained-release theophylline on sleep patterns in nocturnal asthmatics." | 9.08 | An evaluative study of the short-term effects of once-daily, sustained-release theophylline on sleep in nocturnal asthmatics. ( Driver, HS; Richardt, D, 1996) |
| "The anti-inflammatory effects of oral theophylline on cells in bronchial biopsies of symptomatic atopic asthmatic subjects were investigated." | 9.08 | Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study. ( Djukanovic, R; Finnerty, JP; Holgate, ST; Lee, C; Madden, J; Wilson, S, 1996) |
| "Patients with chronic asthma are often treated with sustained-release theophylline preparations." | 9.08 | [Usefulness of "Biotrack Theophylline kit" for measuring serum theophylline concentration in patients with chronic asthma]. ( Iwata, T, 1996) |
| "Nocturnal cough and wheeze are common in asthma and often treated with beta2 agonists or theophyllines." | 9.08 | Inhaled salmeterol or oral theophylline in nocturnal asthma? ( Douglas, NJ; Engleman, HM; Fitzpatrick, MF; Mackay, TW; Selby, C; Sime, PM, 1997) |
| " The present study was undertaken to compare the therapeutic effects of sustained release theophylline and a conventional low dose oral fenoterol in patients with asthma." | 9.08 | Oral fenoterol versus sustained release theophylline in adult asthmatics. ( Almagro, J; Andrade, RJ; Hidalgo Sanchez, R; Lucena, MI; Sanchez de la Cuesta, F, 1997) |
| "We investigated the effect of theophylline administration on circulating vitamin levels in children with asthma." | 9.08 | Relation between theophylline and circulating vitamin levels in children with asthma. ( Arakawa, H; Maeda, S; Mochizuki, H; Morikawa, A; Shimizu, T; Tokuyama, K, 1996) |
| "Although theophylline is recommended by current guidelines for the management of asthma in patients with persistent symptoms, theophylline has a narrow therapeutic index, requiring individual dose titration and regular monitoring of serum theophylline concentrations to avoid adverse effects." | 9.08 | Salmeterol versus theophylline in the treatment of asthma. ( Cox, FM; Emmett, A; Pollard, SJ; Spector, SL; Yancey, SW, 1997) |
| "The aim of the present study was to compare the efficacy and the tolerability of salmeterol and theophylline in patients with nocturnal asthma." | 9.08 | [Therapy of nocturnal asthma: salmeterol versus nocturnal administration of retard theophylline--comparison of effectiveness and tolerance]. ( Braun, H; Koper, I; Leutz, M; Schlimmer, P; Sybrecht, GW; Ukena, D, 1997) |
| "In comparison to beta-agonist drugs, which are the primary bronchodilator drugs in current use in asthma, both oral theophylline and inhaled ipratropium have a weaker bronchodilating action in asthma." | 9.08 | The effects of the combination of inhaled ipratropium and oral theophylline in asthma. ( Burki, NK, 1997) |
| "Inhaled glucosteroids and oral theophylline are widely used to treat asthma." | 9.08 | A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. ( Barnes, PJ; Chung, KF; Evans, DJ; O'Connor, BJ; Taylor, DA; Zetterstrom, O, 1997) |
| "The effect of a single oral dose of cilostazol on BHR was studied in 10 elderly patients with clinically stable asthma, with a mean age of 59." | 9.08 | Effect of a phosphodiesterase 3 inhibitor, cilostazol, on bronchial hyperresponsiveness in elderly patients with asthma. ( Fujimura, M; Hashimoto, T; Kamio, Y; Matsuda, T; Myou, S, 1997) |
| "Zileuton, a leukotriene pathway inhibitor, was compared with slowly absorbed theophylline in a randomized, double-blind study of patients with chronic asthma." | 9.08 | A randomized controlled trial comparing zileuton with theophylline in moderate asthma. The Zileuton Study Group. ( Dubé, LM; Lancaster, JF; Petty, T; Schwartz, HJ; Swanson, LJ, 1998) |
| "Inhaled corticosteroids and oral theophylline are effective treatments for moderate asthma." | 9.08 | Aerosol beclomethasone dipropionate spray compared with theophylline as primary treatment for chronic mild-to-moderate asthma. The American Academy of Allergy, Asthma and Immunology Beclomethasone Dipropionate-Theophylline Study Group. ( Li, JT; Nelson, HS; Offord, KP; Reed, CE; Tinkelman, DG, 1998) |
| "This was a multicenter, randomized, double-blind, parallel-groups study in which 102 asthmatic patients were assigned to one of two treatments: beclomethasone three times daily or theophylline twice daily." | 9.08 | Neuropsychological and behavioral changes in asthmatic children treated with beclomethasone dipropionate versus theophylline. ( Bender, BG; DuHamel, T; Iklé, DN; Tinkelman, D, 1998) |
| "Previous studies evaluating spirometric values and symptoms have shown that once daily theophylline administered in the evening produces greater stabilisation of the airway function in asthmatic patients than the prototype theophylline given twice a day." | 9.08 | Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients. ( Biasin, C; Bonazza, L; Ferrari, M; Lampronti, G; Lo Cascio, V; Nacci, P; Olivieri, M; Talamini, G, 1997) |
| "The anti-asthmatic effects of theophylline may supplement those of inhaled steroids in asthma." | 9.08 | Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma. ( Harnest, U; Keller, A; Leichtl, S; Magyar, P; Rathgeb, F; Sakalauskas, R; Steffen, H; Steinijans, VW; Ukena, D; Vetter, N, 1997) |
| " The purpose of this work was to compare two methods used to quantify plasmatic levels of theophylline in asthmatic patients as support to choose the best method." | 9.08 | Plasmatic levels of theophylline in asthmatic patients. Comparative evaluations of two different methods. ( Flores-Pérez, J; Juárez-Olguín, H; Lares-Asseff, I, 1998) |
| "We investigated whether the deterioration in asthma control reported following cessation of theophylline was due to tolerance to theophylline." | 9.08 | The airway effects of stopping regular oral theophylline in patients with asthma. ( Bennett, JA; Pavord, ID; Tattersfield, AE; Thompson Coon, J; Wilding, PJ, 1998) |
| "The role of aminophylline (ethylene diamine salt of theophylline) in the treatment of acute exacerbation of asthma has not been well established in children." | 9.08 | Efficacy of aminophylline in the treatment of acute asthma exacerbation in children. ( Barlan, IB; Başaran, MM; Dai, A; Nuhoğlu, Y, 1998) |
| "The aim of the present multicentre, open, randomized, parallel group study was to evaluate the efficacy and safety of salmeterol versus theophylline in asthmatic patients." | 9.08 | Long-term treatment of asthmatic patients with salmeterol vs slow-release theophylline. ( Martini, T; Nutini, S; Righi, R, 1998) |
| "Theophylline is a bronchodilator and immunomodulator drug which has recently been demonstrated to attenuate the recruitment and activation of inflammatory cells into lungs of asthmatics." | 9.08 | Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects. ( Costello, JF; Cotter, T; Kilfeather, S; Page, CP; Spina, D; Sullivan, P, 1998) |
| "The anti-asthmatic effect of theophylline may supplement those of inhaled steroids in asthma." | 9.08 | [Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma]. ( Harnest, U; Keller, A; Leichtl, S; Magyar, P; Rathgeb, F; Sakalauskas, R; Steffen, H; Steinijans, VW; Ukena, D; Vetter, N, 1998) |
| "Theophylline has been used as a bronchodilator in acute and chronic asthma management, although there is accumulating evidence that it may have anti-inflammatory effects." | 9.08 | Effect of theophylline withdrawal on airway inflammation in asthma. ( Adachi, M; Akabane, T; Hashimoto, T; Kihara, N; Kobayashi, H; Kohno, Y; Minoguchi, K; Mita, S; Miyamoto, M; Oda, N; Wada, K; Yokoe, T, 1998) |
| "To evaluate the effect of controlled-release theophylline given with the evening meal on the immediate asthmatic response (IAR) and LAR following nighttime antigen challenge in patients with mild atopic asthma." | 9.08 | Theophylline inhibits the late asthmatic response to nighttime antigen challenge in patients with mild atopic asthma. ( Busse, WW; Jarjour, NN; Lacouture, PG, 1998) |
| "Theophylline has been used as a bronchodilator in acute and chronic asthma management but recent evidences suggest that it has anti-inflammatory effects." | 9.08 | [Effect of slow-release theophylline on airway inflammation in bronchial asthma]. ( Adachi, M; Akiyama, K; Kokubu, F; Minoguchi, K; Mita, S; Sano, Y; Suzuki, H; Yasuhara, H, 1998) |
| "The purpose of this study is to determine whether theophylline provides clinical benefits in the hospitalized children with asthma attack." | 9.08 | [Evaluation of theophylline in children hospitalized with asthma attack]. ( Kodama, S; Miyoshi, M; Sakurai, T, 1998) |
| "Eight patients with mild extrinsic asthma participated in a double-blind randomized intraindividual cross-over study involving 6 weeks' treatment with twice daily oral theophylline (2 x 1 capsules = 800 mg/day Cronasma 400) and 6 weeks' treatment with twice daily inhaled budesonide (2 x 2 puffs = 0." | 9.07 | Theophylline vs. budesonide in the treatment of mild-to-moderate bronchial asthma. ( Herceg, R; Matthys, H; Müller, S, 1994) |
| "This study was designed to investigate the effect of sustained-release theophylline therapy on serum pyridoxal concentration in children with bronchial asthma." | 9.07 | [Serum pyridoxal concentration in children during theophylline therapy for bronchial asthma]. ( Fujino, M; Hiraga, Y; Inaba, J; Kobayashi, K; Tanaka, I, 1994) |
| "Theophylline, in addition to its bronchodilator effect, may attenuate inflammation in asthma." | 9.07 | Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. ( Bekir, S; Costello, J; Jaffar, Z; Jeffery, P; Page, C; Sullivan, P, 1994) |
| "The impact of theophylline therapy on neuropsychological (NP) function in adult asthmatics is unclear." | 9.07 | Effect of chronic theophylline therapy on brain blood flow and function in adult asthmatics. ( Anderson, R; Bowton, DL; Stump, DA, 1994) |
| "Patients were recruited from 18 centers and 4 countries to participate in a 1-month double-blind comparison of enprofylline or theophylline in the treatment of asthma and were subsequently maintained on a regimen with the assigned medication for a further 11 months." | 9.07 | Long-term xanthine therapy of asthma. Enprofylline and theophylline compared. International Enprofylline Study Group. ( Chapman, KR; Kallen, A; Ljungholm, K, 1994) |
| "This study compared the efficacy of weekly oral administration of methotrexate and placebo in treatment of 24 subjects with chronic glucocorticosteroid-dependent asthma." | 9.07 | Comparison of oral pulse methotrexate with placebo in the treatment of severe glucocorticosteroid-dependent asthma. ( Diaz, JD; Ledford, DK; Lockey, RF; Seleznick, MJ; Stewart, GE; Trudeau, WL, 1994) |
| "Administration of theophylline to asthmatic children is frequently associated with an adverse influence on their behavior." | 9.07 | Administration of half-dose theophylline together with ketotifen to asthmatic children--a double-blind, placebo-controlled study. ( Amir, J; Lerman, M; Malik, H; Varsano, I; Volovitz, B, 1994) |
| "A randomized trial of long-acting theophylline drugs theopek taken twice daily and euphilong taken in a single daily dose has been performed in 59 elderly patients suffering from bronchial asthma, chronic obstructive bronchitis." | 9.07 | [The comparative efficacy of the prolonged-action theophylline preparations Theopek and Euphylong in elderly patients with chronic obstructive lung diseases]. ( Belousov, IuB; Nonikov, VE; Salikova, VV, 1993) |
| "Sixteen asthmatic patients with normal diurnal activity between 05:00 and 23:00 h participated in this randomized, multiple-dose, double-blind, placebo-controlled, crossover study of the pharmacokinetics and efficacy of evening supplementation of a 12-hourly sustained-release theophylline (SRT) regimen with a nonsustained-release theophylline (NSRT) formulation." | 9.07 | Double-blind randomized cross-over trial of nocturnal elixir theophylline supplementation of a twice-daily sustained-release theophylline tablet formulation in asthmatic patients. ( du Plessis, JB; Le Roux, FP; Middle, MV; Müller, FO; Schall, R, 1993) |
| "To determine the efficacy of theophylline when given in addition to nebulized albuterol and intravenously administered corticosteroid to children hospitalized with mild to moderate asthma." | 9.07 | Hospital treatment of asthma: lack of benefit from theophylline given in addition to nebulized albuterol and intravenously administered corticosteroid. ( Alpert, SE; DiGiulio, GA; Kercsmar, CM; Krug, SE; Marx, CM, 1993) |
| "To determine whether intravenously administered theophylline, when added to frequently nebulized albuterol and intravenously administered methylprednisolone, benefits children hospitalized with severe asthma." | 9.07 | Efficacy of intravenously administered theophylline in children hospitalized with severe asthma. ( Carter, E; Chesrown, S; Cruz, M; Hendeles, L; Reilly, K; Shieh, G, 1993) |
| "Theophylline, a drug used for the treatment of asthma, is recognized as an immunomodulator affecting T-lymphocytes both in vitro and in vivo." | 9.07 | Theophylline--an immunomodulatory role in asthma? ( Costello, JF; Evans, JM; McKenniff, M; Page, CP; Ward, AJ, 1993) |
| "To compare the benefits and adverse reactions of theophylline and beclomethasone (BDP) in the long-term control of mild to moderate chronic asthma in children." | 9.07 | Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. ( Nelson, HS; Offord, KP; Reed, CE; Tinkelman, DG, 1993) |
| "To assess the efficacy and safety of nedocromil sodium metered dose aerosol as an adjunct to sustained-released theophylline therapy in adult theophylline-dependent asthma patients and to examine the ability of nedocromil sodium to substitute for theophylline." | 9.07 | Effects of the addition of nedocromil sodium to maintenance bronchodilator therapy in the management of chronic asthma. ( Callaghan, B; Clancy, L; Teo, NC, 1992) |
| "Ninety-six patients with nocturnal asthma (FEV1 = 60-90% pred, reversibility greater than or equal to 15%, at least 2 awakenings in the week preceding the trial) were included in a double-blind, randomized, crossover, multicenter study which compared the efficacy and side effects of inhaled salmeterol (50 micrograms morning and evening) to the association theophylline-ketotifen (300 mg and 1 mg morning and evening, respectively)." | 9.07 | [Usefulness of salmeterol in nocturnal asthma: a comparative study with theophylline-ketotifen association. A French multicenter group]. ( Georges, D; Muir, JF, 1992) |
| "The aim of this investigation was to study whether certain patients benefit from adding theophylline to the beta 2-agonist treatment of acute asthma." | 9.07 | Which patients benefit from adding theophylline to beta 2-agonist treatment in severe acute asthma? ( Boe, J; Boman, G; Janson, C, 1992) |
| ") to block or mitigate sulfur dioxide (SO2)-induced bronchoconstriction in adult subjects with asthma." | 9.07 | Theophylline mitigates the bronchoconstrictor effects of sulfur dioxide in subjects with asthma. ( Dumler, K; Koenig, JQ; Pierson, WE; Rebolledo, V; Williams, PV, 1992) |
| "Three combination regimens, (1) inhaled albuterol (ALB) with oral theophylline (THEO), (2) inhaled ALB with inhaled beclomethasone dipropionate (BDP), or (3) inhaled ALB, inhaled BDP, and oral THEO, were evaluated and compared as optimal pharmacotherapy for chronic asthma in 111 children." | 9.07 | Long-term comparison of three combinations of albuterol, theophylline, and beclomethasone in children with chronic asthma. ( Eigen, HN; Ellis, EF; Hemstreet, MP; Meltzer, EO; Orgel, HA, 1992) |
| "We conducted a study to evaluate the serum theophylline concentrations and dose interval of Theolan preparation in asthmatic children." | 9.07 | Evaluation of a once-a-day theophylline preparation in asthmatic children. ( Chang, YR; Chao, T; Hwang, B; Tang, RB; Wu, KG, 1992) |
| "Theophylline has been associated with a variety of behavioral side effects in asthmatic children." | 9.07 | Psychological change associated with theophylline treatment of asthmatic children: a 6-month study. ( Bender, BG; Comer, C; Ikle, D; Lerner, JA; Szefler, S, 1991) |
| "In this study we examined the efficacy and pharmacokinetics of a new chrono-optimized theophylline sustained release preparation for once-daily dosing in the evening for treating bronchial asthma." | 9.07 | [24-hour lung function in asthmatic patients: chrono-optimal theophylline therapy as once-daily Euphylong administration vs conventional twice-daily administration]. ( D'Alonzo, GE; Emerson, MB; Feldman, S; Gianotti, LA; Sauter, R; Smolensky, MH; Staudinger, HW; Steinijans, VW, 1991) |
| "The effect of nifedipine on serum theophylline levels in 13 female hypertensive patients having asthma on theophylline therapy has been investigated." | 9.07 | Nifedipine alters serum theophylline levels in asthmatic patients with hypertension. ( Canberk, A; Eroğlu, L; Yilmaz, E, 1991) |
| " The effect of a new quinolone, sparfloxacin, on the pharmacokinetics and metabolism of theophylline was investigated in six asthmatic patients receiving chronic theophylline therapy (a sustained-release theophylline tablet formulation of 200 to 300 mg twice daily at 12-h intervals)." | 9.07 | Effect of a new quinolone, sparfloxacin, on the pharmacokinetics of theophylline in asthmatic patients. ( Hasegawa, T; Kuzuya, T; Nadai, M; Takagi, K; Yamaki, K, 1991) |
| "In a multicentre, randomized, cross-over double-blind, double placebo trial the effectiveness and tolerability of slow-release oral salbutamol (SRS) were compared with those of long-acting (LA) theophylline (T) in the treatment of nocturnal asthma of adults." | 9.07 | [Slow-release salbutamol in the treatment of nocturnal asthma. Result of a comparative study vs. long-acting theophylline]. ( Arnaud, A; Desfougères, JL; Michel, FB; Pappo, M, 1991) |
| "The effect of theophylline and cromolyn sodium on sleep was studied in 10 children with asthma who were 10 to 17 years of age (mean 13." | 9.07 | Sleep quality in children with asthma treated with theophylline or cromolyn sodium. ( Avital, A; Chernick, V; Kryger, M; Pasterkamp, H; Sanchez, I; Steljes, DG, 1991) |
| "To determine whether oral slow-release theophylline inhibits asthmatic reactions and the associated increase of airway responsiveness to methacholine induced by allergens, we examined six asthmatic subjects who developed a dual asthmatic reactions after allergen bronchoprovocation with Dermatophagoides pteronyssinus or with grass pollen." | 9.07 | Theophylline inhibits early and late asthmatic reactions induced by allergens in asthmatic subjects. ( Boschetto, P; Crescioli, S; Fabbri, LM; Mapp, CE; Plebani, M; Pozzani, M; Spinazzi, A, 1991) |
| "The aim of this study was to compare the effects upon gastric secretion of therapeutic doses of aminophylline, with doxofylline, a new xanthine derivative proposed for the treatment of chronic asthma." | 9.06 | The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients. ( Bianchi Porro, G; Grossi, E; Lazzaroni, M, 1990) |
| "A double-blind, randomized, crossover chronic study was done to determine the efficacy of colchicine in 10 atopic patients with asthma." | 9.06 | A clinical and immunologic study of colchicine in asthma. ( Garty, MS; Greif, J; Ilfeld, DN; Kivity, S; Schlesinger, M; Schwarz, YA; Topilsky, M, 1990) |
| "To determine the efficacy of nedocromil sodium in adult asthma patients using bronchodilators alone to control their disease, a consecutive sample of 127 patients with long-term asthma was studied for 16 weeks." | 9.06 | A double-blind multicenter group comparative study of the efficacy and safety of nedocromil sodium in the management of asthma. North American Tilade Study Group. ( , 1990) |
| "Nine adult asthmatics with a history of nocturnal symptoms and with morning dips in peak expiratory flow (PEF) were treated for 10-14 days with 24-h controlled-release preparation of theophylline (Th), or a controlled-release preparation of terbutaline (Te), in a double-blind cross-over experiment." | 9.06 | Nocturnal oxygen saturation and body movement in asthmatics treated with controlled-release preparations of theophylline or terbutaline. ( Brander, PE; Hakulinen, A; Poppius, H; Salmi, T; Sovijärvi, AR, 1990) |
| "Enprofylline, a drug without adenosine antagonism and theophylline, a potent adenosine antagonist, were compared, double-blind, randomized, in acute asthma (n = 33)." | 9.06 | Comparison between theophylline and an adenosine non-blocking xanthine in acute asthma. ( Amundsen, T; Brenna, E; Eriksson, G; Holte, S; Källén, AG; Naustdal, T; Persson, CG; Storstein, L; Syvertsen, U; Vilsvik, JS, 1990) |
| "131 asthmatics aged 12-65 years, who still had symptoms despite inhaled or oral bronchodilators, were included in this double-blind group comparative study involving nedocromil sodium (2 puffs of 2 mg each twice daily) and placebo (2 puffs twice daily)." | 9.06 | [Nedocromil sodium therapy in asthma patients. Therapeutic effect in addition to treatment with oral theophylline and inhaled bronchodilator agents]. ( Beck, W; Boos, R; van Kampen, C; Weede, W, 1989) |
| "Percentage reductions in the peak flow rates to a standardized number of histamine inhalations were compared after 7 days of treatment with 10 mg bd tazifylline and after 7 days of placebo in a randomized crossover study in 11 male seasonal atopic asthmatics." | 9.06 | The reducing effects of tazifylline on histamine-induced bronchoconstriction in atopic asthmatics. ( Harlow, B; Kiviranta, K; Reuter, C; Scott, J; Stenius-Aarniala, B, 1989) |
| "We tested an aminophylline loading-dose protocol in which asthmatic patients presenting to an emergency department were given a half (3 mg/kg) IV loading dose based on total body weight (TBW) if they had taken a short-acting or sustained-release theophylline preparation within 12 or 24 hours, respectively, prior to arrival: otherwise, a full (6 mg/kg) loading dose was administered." | 9.06 | Aminophylline loading in asthmatic patients: a protocol trial. ( Marcus, RH; Parvin, CA; Stine, RJ, 1989) |
| "To evaluate the long-term effects of slow-release formulations of theophylline and terbutaline on pulmonary function, clinical symptoms, and side effects, 24 children with stable and moderately severe perennial asthma participated in a prospective double-blind cross-over study." | 9.06 | Slow-release terbutaline and theophylline for the long-term therapy of children with asthma: a Latin square and factorial study of drug effects and interactions. ( Chow, OK; Fung, KP, 1989) |
| "Potential day-night differences of theophylline absorption and disposition were examined in day-active asthmatic children." | 9.06 | Day-night differences in steady-state theophylline pharmacokinetics in asthmatic children. ( Baenziger, JC; Eigen, H; Harrist, RB; Hiatt, PW; Klank, BJ; Kramer, WG; Scott, PH; Smolensky, MH, 1989) |
| "In a group of ten patients with chronic asthmatic bronchitis, the effect of monotherapy with theophylline and terbutaline and the combination of both drugs, as sustained-release tablets, was compared to placebo, in a double-blind cross-over, triple dummy at random study." | 9.06 | Combination therapy of theophylline and terbutaline as sustained-release preparations in patients with asthmatic bronchitis. ( Fokkens, JK; Hamelink, MJ; Kreukniet, J; Maes, RA; van der Vet, AP; van Drost, RH, 1987) |
| "We studied 15 nonsmoking, clinically stable asthmatic subjects aged 27 to 39 years to evaluate the potential cardiotoxic effects of combined use of a beta-adrenergic agonist drug and theophylline in the treatment of asthma." | 9.06 | Cardiac arrhythmias during the combined use of beta-adrenergic agonist drugs and theophylline. ( Barker, AF; Buist, AS; Coleman, JJ; Schultz, GE; Vollmer, WM, 1986) |
| "Forty patients suffering from asthmatic conditions, often accompanied by emphysema, were treated either with an extempore combination of salbutamol syrup plus 30-mg oxatomide tablets or with 30-mg oxatomide tablets alone for purposes of comparison." | 9.06 | Treatment of asthma with an extempore combination of a bronchodilator, salbutamol, and a new antihistamine drug, oxatomide. ( Caprioglio, L; Scremin, S, 1986) |
| "The effect of long-term treatment with theophylline was studied in 20 chronic asthmatic patients receiving oral and inhaled beta 2-agonists." | 9.06 | Theophylline in maintenance treatment of chronic asthma: concentration-dependent additional effect to beta 2-agonist therapy. ( Billing, B; Dahlqvist, R; Hörnblad, Y; Leideman, T; Ripe, E; Skareke, L, 1987) |
| "This study examined the potential side effects of theophylline on behavior, attention, memory, and fine motor function in children with asthma." | 9.06 | Effects of theophylline on behavior and learning in children with asthma. ( Coffman, H; DeGraw, C; Fenton, T; Guare, R; Rappaport, L; Twarog, F, 1989) |
| "The effects on bronchoconstriction, on non-specific bronchial hyperreactivity (nBH), and the pharmacokinetics at steady state of two theophylline preparations, controlled release (CR) capsules (Riker Pharmaceuticals) and UnixanR tablets (Pharmacia) were compared in patients with nocturnal asthma." | 9.06 | Comparison between steady state pharmacokinetics and effects of two once-daily, slow-release theophylline formulations in nocturnal asthma. ( Almind, M; Frølund, L; Madsen, F; Nielsen, NH; Svendsen, UG; Weeke, B, 1988) |
| "After one week theophylline therapy with a sustained release preparation (TheoDur 200 and 300 mg), a mean theophylline level of 10 mg/l was obtained in a group of ten patients with chronic asthmatic bronchitis with a mean dosage of 760 mg theophylline/24 h." | 9.06 | Lung function improvement, tremor measurements and c-AMP determinations in a group of ten patients with asthmatic bronchitis after one week sustained release theophylline medication (theophylline plasma level +/- 10 mg/l) compared to one week placebo. ( Drost, RH; Fokkens, JK; Hamelink, ML; Kreukniet, J; Maes, RA; Van der Vet, AP, 1986) |
| "Ninety-six patients with reversible airways disease and a history of nocturnal asthma completed a four-week open-label study that compared the effectiveness of Uniphyl tablets (The Purdue Frederick Company, Norwalk, Connecticut) administered once daily in the morning or the evening with twice-daily baseline theophylline therapy." | 9.06 | Multicenter comparison of once-daily Uniphyl tablets administered in the morning or evening with baseline twice-daily theophylline therapy in patients with nocturnal asthma. ( Grossman, J, 1988) |
| "Twenty-one patients, 12 to 18 years of age, with nocturnal asthma controlled with sustained-release theophylline administered twice daily, were enrolled in a 10-week, double-blind, two-way crossover study that compared Theo-Dur tablets administered twice daily with an equivalent daily dose of Uniphyl tablets administered once daily at bedtime." | 9.06 | Is a uniform round-the-clock theophylline blood level necessary for optimal asthma therapy in the adolescent patient? ( Bierman, CW; Furukawa, CT; Pierson, WE; Shapiro, GG, 1988) |
| "Forty adult patients with chronic asthma completed a 3-month double-blind crossover study to compare the effect of sustained-release theophylline given both as a fixed 300 mg twice daily dose (standard) and an individually titrated dose (titrated) with placebo." | 9.06 | A double-blind, placebo-controlled comparison of the efficacy of standard and individually titrated doses of theophylline in patients with chronic asthma. ( Barlow, TJ; Graham, P; Harris, JM; Hartley, JP; Turton, CW, 1988) |
| "The effects of a new inhaled antimuscarinic drug, oxitropium bromide, and of a slow-release theophylline preparation upon nocturnal asthma were compared in a placebo-controlled double-blind study." | 9.06 | Comparison of the effect of oxitropium bromide and of slow-release theophylline on nocturnal asthma. ( Bellia, V; Cibella, F; Cuttitta, G; Ferrara, G; Insalaco, G; Mirto, M; Peralta, G; Visconti, A, 1988) |
| "Sixteen patients were included in the analysis of this double-blind crossover study comparing the effect of sodium cromoglycate, reproterol, sodium cromoglycate plus reproterol, and placebo in exercise-induced asthma." | 9.06 | Double-blind crossover study comparing sodium cromoglycate, reproterol, reproterol plus sodium cromoglycate, and placebo in exercise-induced asthma. ( Debelić, M; Hertel, G; König, J, 1988) |
| "The aim of this study was to evaluate the effect of a sustained-release theophylline preparation on bronchial responsiveness to cold dry air inhalation in asthmatic subjects." | 9.06 | Theophylline minimally inhibits bronchoconstriction induced by dry cold air inhalation in asthmatic subjects. ( Cartier, A; Ghezzo, H; L'Archevêque, J; Malo, JL; Merland, N, 1988) |
| "Two theophylline treatments were compared in a randomized, multiple-dose, crossover study on 20 patients present with nonallergic bronchial asthma." | 9.06 | Therapeutic advantage of unequal dosing of theophylline in patients with nocturnal asthma. ( Dorow, P; Steinijans, VW, 1987) |
| "Twenty school children with chronic asthma who despite regular prophylactic therapy continued to have troublesome nocturnal wheeze or cough entered a double-blind cross-over study in which a once daily theophylline preparation was compared with placebo to assess control of these symptoms." | 9.06 | A once daily theophylline preparation in prevention of nocturnal symptoms in childhood asthma. ( Bose, B; Cater, JI; Clark, RA, 1987) |
| "The effect of adding slow release nifedipine to oral theophylline has been studied in eight patients with stable but symptomatic asthma, a double blind placebo controlled crossover protocol being used." | 9.06 | Effect of nifedipine on serum theophylline concentrations and asthma control. ( Kendall, MJ; Skinner, C; Smith, SR; Stableforth, DE; Wiggins, J, 1987) |
| "Concern about side-effects of theophylline prompted us to investigate whether this drug could be eliminated from the multi-medication regimen of severe asthmatics." | 9.06 | Need for theophylline in severe steroid-requiring asthmatics. ( Berkowitz, R; Brenner, M; Marshall, N; Strunk, RC, 1988) |
| "This study was performed in a randomized double-blind manner on 6 separate days in 10 asthmatic patients to investigate the effect of a sustained theophylline on baseline bronchial hyperreactivity to histamine in relation to the theophylline serum levels and the degree of bronchodilatation produced." | 9.06 | Relationship of serum theophylline concentrations to histamine-induced bronchospasm. ( Ciccarello, C; Crimi, N; Distefano, SM; Mistretta, A; Oliveri, R; Palermo, B; Palermo, F; Vancheri, C, 1987) |
| "A new sustained-release theophylline preparation has been designed with the purpose of providing 24-hour protection against bronchospasm in asthmatics when given as a single dose." | 9.06 | Once daily theophylline in childhood asthma. ( Levene, S; McKenzie, S, 1986) |
| "Because there are few published studies on capsulized sustained-release theophylline (SRT) products in children, we compared Slo-bid capsules to Theo-Dur tablets in a group of school age children and young adults with asthma in an 8-week randomized crossover study design with patients maintaining daily symptom diary cards and peak expiratory flow rates." | 9.06 | Comparison study of sustained-release theophylline products: Slo-bid capsules versus Theo-Dur tablets in 20 children and young adults with asthma. ( Hannaway, PJ; Hopper, GD, 1986) |
| "In a four-week study, 20 children with chronic asthma were treated in a randomized, double-blind, crossover manner with two sustained-release theophylline preparations (Theo-Dur and Uniphyl) to compare their drug concentrations and clinical efficacy." | 9.06 | Sustained-release theophylline preparations in asthmatic children. A short-term comparison of two products and the relationship of serum theophylline levels and pulmonary function changes. ( Gracey, V; Katz, R; Mickey, MR; Rachelefsky, G; Rohr, A; Siegel, S; Spector, S; Wo, J, 1986) |
| "Thirty-nine patients with asthma requiring acute treatment were included in a randomized, double-blind, parallel study which compared the effect of enprofylline (1." | 9.06 | Comparison of enprofylline and theophylline for intravenous treatment of acute asthma. ( Eriksson, G; Haahtela, T; Venho, K, 1986) |
| "The bronchial responsiveness of a group of asthmatic children was studied using histamine stimulation after a single dose of theophylline and after placebo." | 9.06 | Protective effect of theophylline on histamine-induced bronchoconstriction in asthmatic children. ( Levene, S; McKenzie, SA, 1986) |
| "Fifteen asthmatic outpatients were randomly treated during two periods of 14 days each with sustained-release preparations of either enprofylline (3-propyl-xanthine) or theophylline (Theo-Dur) in a double-blind crossover study." | 9.06 | Enprofylline and theophylline slow-eroding tablets in the treatment of asthma: a comparison. ( Eriksson, G; Laursen, LC; Weeke, B, 1986) |
| "The efficacy and side effects of oral or inhaled terbutaline were examined in 13 mild-to-moderate asthmatic patients (ages 12 to 71 years) on maintenance theophylline (levels 10 to 25 micrograms/ml)." | 9.06 | Addition of terbutaline to optimal theophylline therapy. Double blind crossover study in asthmatic patients. ( Kray, KT; Nelson, HS; Vandewalker, ML; Weber, RW, 1986) |
| "Two slow-release preparations of theophylline have been compared in an open crossover trial in the treatment of 20 asthmatic children." | 9.06 | Comparison of two new controlled-release theophylline formulations in the management of asthma in children and reliability of salivary theophylline concentration. ( Bennati, D; Boner, AL; Gaburro, D; Miglioranzi, P, 1986) |
| "To compare the acute bronchodilator effect of increasing doses of intravenous theophylline and inhaled beta adrenergic agonists, we administered intravenous theophylline dissolved in ethylenediamine or proxyphylline and diprophylline or placebo in a double blind fashion to nine asthmatics on three different days." | 9.06 | Bronchodilator effect of theophylline preparations and aerosol fenoterol in stable asthma. ( Hartmann, V; Jörres, R; Magnussen, H, 1986) |
| "The therapeutic effects of either morning or evening administration of a once-daily controlled release theophylline preparation (Uniphyllin) were studied in 17 asthmatic children." | 9.06 | Once a day theophylline in chronic childhood asthma? ( Davies, H; Helms, P; Leakey, T; Stroobant, J, 1986) |
| "A double blind crossover trial with active or placebo slow release theophylline (Slo-phyllin) in children with asthma aged up to 4 years is described." | 9.06 | Slow release theophylline in preschool asthmatics. ( Conway, SP; Houlsby, WT, 1986) |
| "The extrapulmonary effects of slow-release theophylline and an inhaled beta 2-agonist (albuterol) were examined separately and in combination among 18 adults and adolescents with asthma during a 3-month randomized, double-blind, crossover trial." | 9.06 | Extrapulmonary effects of maintenance therapy with theophylline and inhaled albuterol in patients with chronic asthma. ( Ahrens, RC; Joad, JP; Lindgren, SD; Weinberger, MM, 1986) |
| "Five different doses of enprofylline, a 3-propylxanthine, were compared with a standard dose of theophylline in 135 episodes of acute asthma in a double-blind study." | 9.06 | Efficacy of enprofylline, a new bronchodilating xanthine, in acute asthma. ( Boe, J; Eriksson, G; Ljungholm, K, 1987) |
| "Theophylline level variability obtained with standard slow-release theophylline tablets was compared to that obtained with a new sustained-release theophylline suspension in asthmatic children." | 9.06 | A new sustained-release theophylline suspension for asthmatic children: evaluation of serum theophylline concentrations. ( Bernocchi, D; Boner, AL; Plebani, M; Valletta, E; Vallone, G, 1987) |
| "Serum theophylline levels produced by two bands of sustained-release theophylline tablets, TheoDur and Respbid, were compared in a double-blind crossover study in 13 asthmatic children." | 9.06 | Serum drug fluctuations after administration of two sustained-release oral theophylline preparations in asthmatic children. ( Logvinoff, MM; Seifert, B; Watts, MT; Weinstein, DB, 1986) |
| " for 2 weeks, was studied in a randomized, double-blind, crossover trial in nine patients with asthma receiving theophylline." | 9.06 | Effect of nifedipine and theophylline in asthma. ( Cohen, E; Garty, M; Ilfeld, DN; Mazar, A; Rosenfeld, JB; Spitzer, S, 1986) |
| "The goal of the current study was to determine whether administration of a methylxanthine preparation in the form of a retention enema (theophylline-diprophylline-proxyphylline combination, Neobiphyllin-Clys) has an effect similar to that of intravenous theophylline in the treatment of acute bronchospasm." | 9.06 | Effect of a methylxanthine preparation in the form of a retention enema on pulmonary function and theophylline levels in patients with acute bronchospasm. ( Dorow, P; Dougherty, C; Schenk, H, 1986) |
| "Sustained-release, 24-hour theophylline preparations have been formulated and may provide for convenient once-a-day dosing, although the use of such products in clinical asthma has yet to be fully established." | 9.06 | The use of a single daily theophylline dose and metered-dose albuterol in asthma treatment. ( Bush, RK; Busse, WW; Smith, A, 1986) |
| "The effect on bronchial smooth muscle of slow release theophylline plus placebo and theophylline plus slow release nifedipine administered for a prolonged period to 12 asthmatic and hypertensive patients has been studied." | 9.06 | Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma. ( Lombardi, C; Spedini, C, 1986) |
| "The relative benefit of maintenance therapy with theophylline, inhaled albuterol, and the combination was examined in 18 adolescents and adults with chronic asthma during a 3-month, randomized, double-blind, crossover trial." | 9.06 | Relative efficacy of maintenance therapy with theophylline, inhaled albuterol, and the combination for chronic asthma. ( Ahrens, RC; Joad, JP; Lindgren, SD; Weinberger, MM, 1987) |
| "We investigated the intensity and duration of the effect of a single dose of slow-release theophylline on bronchial hyperresponsiveness to ultrasonically nebulized distilled water in asthma." | 9.06 | Long-lasting protective effect of slow-release theophylline on asthma induced by ultrasonically nebulized distilled water. ( Alessandri, MV; De Marzo, N; Fabbri, LM; Mapp, CE; Paleari, D; Pozzan, M; Zocca, E, 1986) |
| "Sixty-one chronic asthmatic children received either a new slow-release sprinkle format of theophylline, twice daily, or theophylline liquid, 4-times per day." | 9.06 | A comparative study of theophylline in a slow-release 'sprinkle' format with a standard syrup preparation in young children with asthma. ( Dawson, KP, 1986) |
| "Theophylline is still one of the most widely prescribed drugs for the treatment of asthma and COPD in developing countries because the majority of asthma and COPD medicines are largely unavailable and also because it is a cheap option." | 9.05 | The effect of doxofylline in asthma and COPD. ( Cazzola, M; Matera, MG, 2020) |
| "A randomized multicentre trial was done to investigate the protective effects of ketotifen and disodium cromoglycate (DSCG) in the therapy of bronchial asthma." | 9.05 | [Treatment of seasonal asthmatic symptoms. A multicentre trial to compare the effects of ketotifen and disodium cromoglycate (author's transl)]. ( Borelli, S; Düngemann, H; Schiess, W, 1980) |
| "Twelve asthmatic patients with nocturnal wheezing were given a single nocturnal oral dose of slow-release aminophylline or matched placebo in a double-blind crossover trial." | 9.05 | Single-dose slow-release aminophylline at night prevents nocturnal asthma. ( Barnes, PJ; Greening, AP; Neville, L; Poole, GW; Timmers, J, 1982) |
| "5 mg) combined with 280 mg anhydrous theophylline orally in the randomized, double-blind, cross-over study in eight asthmatics." | 9.05 | Effects of oral theophylline combined with oral and inhaled beta-2-adrenostimulants in asthmatics. ( Svedmyr, K, 1982) |
| "The therapeutic value of adding a slow-release theophylline product (Theo-Dur) to the regular treatment program consisting of beta-stimulants and steroids was evaluated in 31 adult asthmatics." | 9.05 | Combined theophylline/beta-agonists maintenance therapy in chronic asthma. ( Eriksson, NE; Ewald, U; Haglind, K, 1983) |
| "In two groups of patients, 15 with asthma and 15 with chronic bronchitis, the bronchodilator effects of ipratropium bromide, of fenoterol plus theophylline, and of the combination of the three drugs, were compared using a double-blind, single-dose, placebo-controlled format." | 9.05 | The addition of an aerosol anticholinergic to an oral beta agonist plus theophylline in asthma and bronchitis. A double-blind single dose study. ( Baskerville, J; Blennerhassett, G; Lefcoe, NM; Paterson, NA; Toogood, JH, 1982) |
| "The role of the anticholinergic drug, ipratropium bromide, in maintenance antiasthmatic therapy was evaluated in a double-blind crossover trial of three bronchodilator regimens: (1) inhaled ipratropium, placebo, and oral oxtriphylline; (2) inhaled fenoterol, placebo, and oral oxtriphylline; and (3) both inhaled ipratropium and fenoterol plus oral oxtriphylline." | 9.05 | Anticholinergic and sympathomimetic combination therapy of asthma. ( Chapman, KR; Gent, M; Rebuck, AS, 1983) |
| "Ipratropium (40 micrograms) and theophylline (oxtriphylline 400 mg) were administered to 24 asthmatics in a randomized double-blind placebo controlled trial." | 9.05 | Combined therapy with ipratropium and theophylline in asthma. ( Cohen, C; Frank, H; Ghezzo, H; Kreisman, H; Vickerson, F; Wolkove, N, 1984) |
| "In 6 asthmatic patients, the possibility of obtaining a steady state plasma level of 5 mg/l of enprofylline by administration of two constant rate infusions was examined." | 9.05 | Intravenous administration of enprofylline to asthmatic patients. ( Fagerström, PO; Johannesson, N; Laursen, LC; Weeke, B, 1983) |
| "A double blind crossover comparison of slow-release theophylline, ketotifen and placebo was carried out in 18 young children with perennial asthma." | 9.05 | A controlled comparison of slow-release theophylline, ketotifen and placebo in the prophylaxis of asthma in young children. ( Carswell, F; Fysh, WJ; Hughes, AO; Robinson, P; Stratton, D, 1983) |
| "A double-blind randomized study of 50 patients was conducted to evaluate the efficacy and safety of terbutaline sulfate aerosol and isoproterenol sulfate aerosol in the treatment of patients with moderate to severe asthma." | 9.05 | Terbutaline sulfate and isoproterenol sulfate (metered dose aerosols) in the treatment of asthma. ( Kemp, JP; Meltzer, EO; Orgel, HA; Welch, MJ, 1983) |
| "Clinical trials of slow-release theophylline and ketotifen as prophylaxis against asthma in 18 young children suggested that both drugs had some efficacy." | 9.05 | Double-blind comparisons of slow-release theophylline, ketotifen and placebo for prophylaxis of asthma in young children. ( Carswell, F; Fysh, WJ; Hughes, AO; Robinson, P; Stratton, D, 1984) |
| "The effects of a therapeutic serum theophylline concentration on inhaled methacholine and histamine were studied in 8 stable, moderately severe asthmatic children 8 to 15 yr of age." | 9.05 | Effects of theophylline on inhaled methacholine and histamine in asthmatic children. ( Howick, J; Kelly, HW; McWilliams, BC; Menendez, R, 1984) |
| "Twenty-five asthmatic outpatients were treated for 3 one-week periods with either enprofylline slowly eroding 300 mg tablets t." | 9.05 | Continuous treatment of asthmatic patients with enprofylline and theophylline. ( Johannesson, N; Laursen, LC; Weeke, B, 1984) |
| "Verofylline, a long-acting polysubstituted methylxanthine bronchodilator, was taken orally by eight adult patients with asthma in a double-blind, crossover tolerance study." | 9.05 | Verofylline, a methylxanthine bronchodilator, in asthma. ( Booker, WM; Lucas, SG; Malveaux, FJ; Morris, EA; Pittman, J; Rachal, RE; Young, RC, 1984) |
| "Twice daily sustained release theophylline gave satisfactory steady serum theophylline concentrations in asthmatic children aged 7 to 14 years." | 9.05 | Sustained release theophylline in nocturnal asthma. ( Barnes, ND; Elias-Jones, AC; Godden, DJ; Higenbottam, TW, 1984) |
| "The effectiveness of cromolyn sodium and theophylline on asthma in children was compared during a 3-month trial." | 9.05 | A double-blind study comparing the effectiveness of cromolyn sodium and sustained-release theophylline in childhood asthma. ( Bierman, CW; Furukawa, CT; Kraemer, MJ; Pierson, WE; Shapiro, GG; Ward, DJ, 1984) |
| "The bronchodilator effect and side-effects of a single oral dose of enprofylline were compared with the corresponding actions of a therapeutic dose of theophylline in 20 asthmatic patients, in a randomized cross-over clinical trial." | 9.05 | Comparison of oral enprofylline and theophylline in asthmatic patients. ( Johannesson, N; Laursen, LC; Søndergaard, I; Weeke, B, 1984) |
| "A comparison of pharmacokinetics and therapeutic effects of a standard oral theophylline preparation (Choline Theophyllinate) and controlled release aminophylline (Phyllocontin) was made in two parallel double blind trials in 25 children with chronic asthma." | 9.05 | A comparative trial of choline theophyllinate and controlled release aminophylline in chronic childhood asthma. ( Helms, P; Pearl, K; Wilson, R, 1983) |
| "A higher incidence of fatal asthma after increased use of combined inhaled beta 2-agonists and theophylline has been attributed to additive cardiac toxicity of these agents." | 9.05 | Concomitant bitolterol mesylate aerosol and theophylline for asthma therapy, with 24 hr electrocardiographic monitoring. ( Chervinsky, P; Kemp, JP; Meltzer, EO; Mingo, TS; Noyes, JH; Orgel, HA, 1984) |
| "There is evidence that theophylline therapy inhibits lower esophageal sphincter pressure and enhances gastroesophageal reflux in normal adults and adult asthmatics." | 9.05 | Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy. ( Berquist, WE; Katz, R; Rachelefsky, GS; Rowshan, N; Siegel, S; Welch, M, 1984) |
| "A double-blind randomised controlled trial was conducted to study the effects of oral theophylline alone compared with oral theophylline and salbutamol in a sample of asthmatic children." | 9.05 | Effects of oral theophylline and oral salbutamol in the treatment of asthma. ( Dawson, KP; Fergusson, DM, 1982) |
| "Twenty-one patients, suffering from bronchial asthma, with a moderate and clearly reversible airway obstruction, completed a double-blind cross-over trial of two theophylline sustained-release preparations, Theolair Retard (= Theolair S." | 9.05 | A double-blind comparative trial between two sustained-release theophylline preparations with individual doses in asthmatic in-patients. ( Van Alphen, AC; Van Altena, R; Van der Meer, YG; Van Loenen, AC, 1982) |
| "The effect of adding theophylline to treatment with a beta2-adrenoceptor stimulant was studied in 18 asthmatic children in a double-blind cross-over trial." | 9.05 | Combined treatment with sustained-release theophylline and beta2-adrenoceptor-stimulating agents in chronic childhood asthma. ( Foucard, T; Lindström, B; Lönnerholm, G, 1981) |
| "Slow-release aminophylline, although widely used for the prophylaxis of childhood asthma, has had only limited formal assessment." | 9.05 | Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid? ( Silverman, M; Wilson, N, 1982) |
| "The efficacy of nebulised sodium cromoglycate and an oral theophylline solution at currently recommended doses were compared in one to six-year-old children with chronic asthma." | 9.05 | Comparison of nebulised sodium cromoglycate and oral theophylline in controlling symptoms of chronic asthma in pre-school children: a double blind study. ( Newth, CJ; Newth, CV; Turner, JA, 1982) |
| "Oral administration of salbutamol and theophylline has been shown to be effective in relieving bronchoconstriction in asthmatic children aged between 3 and 5 years." | 9.05 | Efficacy of orally administered salbutamol and theophylline in pre-schoolchildren with asthma. ( Groggins, RC; Lenney, W; Milner, AD; Stokes, GM, 1980) |
| "In a double-blind controlled trial 14 chronic asthmatic patients with regular nocturnal exacerbations took 16 mg slow-release oral salbutamol (two Ventolin spandets), 450 mg slow-release aminophylline (two Phyllocontin Continus tablets), or placebo at midnight." | 9.05 | Slow-release oral salbutamol and aminophylline in nocturnal asthma: relation of overnight changes in lung function and plasma drug levels. ( Davies, HJ; Fairfax, AJ; McNabb, WR; Spiro, SG, 1980) |
| "We examined the value of maintenance theophylline at serum concentrations of 10 to 20 micrograms per milliliter in a placebo-controlled, randomized, double-blind trial of 33 children with steroid-dependent chronic asthma." | 9.05 | The value of maintenance theophylline in steroid-dependent asthma. ( Huntley, W; Nassif, EG; Thompson, R; Weinberger, M, 1981) |
| "The bronchodilator response to aerosolized terbutaline and optimal doses of theophylline, given singly and in combination, was studied in ten patients with perennial asthma." | 9.05 | Theophylline and aerosolized terbutaline in the treatment of bronchial asthma. Double-blind comparison of optimal doses. ( Nelson, HS; Smith, JA; Weber, RW, 1980) |
| "The efficacy of metaproterenol (orciprenaline) and theophylline given orally at currently recommended doses was examined in 34 children with chronic asthma using a randomized double-blind cross-over evaluation of four weeks' duration for each active regimen." | 9.05 | Comparison of orally administered metaproterenol and theophylline in the control of chronic asthma. ( Dusdieker, L; Ekwo, EE; Green, M; Smith, GD; Weinberger, M, 1982) |
| "Eleven asthmatic children less than six years were treated double-blind for eight weeks with fenoterol, theophylline or placebo syrups." | 9.05 | Comparison of the long-term effect of fenoterol hydrobromide and theophylline syrups in pre-school asthmatic children. ( Levison, H; Mindorff, C; Nolan, G; Reilly, PA, 1982) |
| "Twenty asthmatic children who had daily wheezing requiring constant medication as outpatients were given oral metaproterenol or oral theophylline in a randomized double-blind crossover study." | 9.05 | A comparison of metaproterenol and theophylline for control of childhood asthma. ( Oppenheimer, PJ; Schuller, DE, 1982) |
| "The bioavailability of three different theophylline tablets (microcrystallinic theophylline, Theolair, Nuelin, 3M Riker), choline theophyllinate as a new film-coated tablet (Teovent, Ferrosan, Sweden) and theophyllaminopropanol (Oxyphylline, Draco, Sweden) was investigated in eight adult asthmatics and a randomized, double-blind, cross-over study." | 9.05 | Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation. ( Mellstrand, T; Svedmyr, K; Svedmyr, N, 1982) |
| "The effects of oral doses of theophylline and a beta-adrenergic agonist, fenoterol, were examined in 18 asthmatic young adults." | 9.05 | The effects of oral doses of theophylline and fenoterol on exercise-induced asthma. ( Beasley, PP; Eggleston, PA; Kindley, RT, 1981) |
| "Theophylline concentrations in saliva have been compared with those in serum in 13 asthmatic patients after single and multiple oral dosage of a microcrystalline theophylline tablet (Nuelin) and a sustained-release preparation (Nuelin Retard)." | 9.05 | Theophylline concentrations in serum and saliva after oral microcrystalline and sustained-release preparations in asthmatics. ( Munch, EP; Søndergaard, I; Weeke, B, 1981) |
| "Forty-eight patients who presented with acute episodes of asthma were randomized to treatment with subcutaneously administered epinephrine, inhaled isoproterenol, or intravenously administered aminophylline." | 9.05 | Emergency therapy of asthma: comparison of the acute effects of parenteral and inhaled sympathomimetics and infused aminophylline. ( Fanta, CH; Goldstein, DH; McFadden, ER; Rossing, TH; Snapper, JR, 1980) |
| "Metaproterenol (M) and theophylline (T) were compared in an eight-week randomized, double-blind, crossover study in 20 moderately severe asthmatic children." | 9.05 | Metaproterenol and theophylline in asthmatic children. ( Katz, RM; Mickey, MR; Rachelefsky, GS; Siegel, SC, 1980) |
| "Bronchodilation and side effects of 28 days treatment with either a full therapeutic dose of theophylline slow-release preparation 500 mg twice daily (400-600 mg), a slow-release terbutaline preparation 10 mg twice daily or combinations of the 2 drugs in full or half doses were evaluated in 31 asthmatic outpatients in a double-blind, randomized crossover design." | 9.05 | Long-term oral therapy of asthma with terbutaline and theophylline, alone and combined. ( Gnosspelius, Y; Gymose, E; Laursen, LC; Taudorf, E; Weeke, B, 1985) |
| "We studied 40 patients with acute exacerbations of asthma to determine the efficacy of a 3-h intravenous infusion of aminophylline in patients who were already being treated with an inhaled beta-adrenergic agonist (metaproterenol)." | 9.05 | Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma. ( Gelb, A; Sheppard, D; Siegel, D; Weinberg, PF, 1985) |
| "In a placebo-controlled, double-blind cross-over study of 2 X 3 weeks' duration, twenty-four children with stable asthma who were wheezing during the night, were treated with a single dose of sustained-release theophylline (SRT) taken after supper." | 9.05 | Treatment of nocturnal asthma in children with a single dose of sustained-release theophylline taken after supper. ( Pedersen, S, 1985) |
| "1 mg/kg/6 hr) or placebo to 2- to 6-year old children whose extrinsic asthma was treated with maintenance theophylline in a prerandomized, double-blind crossover study design." | 9.05 | Albuterol syrup in the treatment of asthma. ( Bierman, CW; Furukawa, CT; Pierson, WE; Shapiro, GG, 1985) |
| "Three hundred seventy-four patients with asthma were entered into a year-long, double-blind, double-placebo controlled study comparing the prophylactic effect of ketotifen (229 patients), theophylline (73 patients), and placebo (72 patients)." | 9.05 | A multicenter trial of the prophylactic effect of ketotifen, theophylline, and placebo in atopic asthma. ( Buckley, CE; Bukantz, SC; Chodosh, S; Cohen, BM; Dobken, JH; Moss, BA; Rappaport, I; Rosenthal, RR; Sheffer, AL; Tinkelman, DG, 1985) |
| "A double-blind crossover comparison of a 12-hour theophylline preparation (Theo-Dur) and a 24-hour theophylline preparation (Theo-24) was conducted with 20 young adult chronic asthmatic patients requiring daily bronchodilator therapy." | 9.05 | A comparative trial of the clinical efficacy and pharmacokinetics of 12-hour and 24-hour controlled release theophylline preparations in patients with chronic asthma. ( Decouto, J; Edelman, L; Janky, DG; Miller, E; Tinkelman, DG, 1985) |
| "Eight asthmatic out-patients with a history of exercise-induced asthma (EIA) were randomly treated with intravenously administered enprofylline 1." | 9.05 | Effects of enprofylline and theophylline on exercise-induced asthma. ( Johannesson, N; Laursen, LC; Weeke, B, 1985) |
| "Twenty-seven asthmatic outpatients were randomly treated with bambuterol 30 mg administered once daily before going to bed and sustained release terbutaline 10 mg twice daily in a 14 day, double blind cross over study." | 9.05 | Bambuterol: effects of a new anti-asthmatic drug. ( Faurschou, P; Gnosspelius, Y; Laursen, LC; Pedersen, BK; Weeke, B, 1985) |
| "Treatment of chronic perennial childhood asthma with cromolyn sodium (CS) or long-acting theophylline (LAT) was compared in 13 children by a double-blind, cross-over trial in which each drug was administered for 4 wk." | 9.05 | Clinical, physiologic, and psychologic comparison of treatment by cromolyn or theophylline in childhood asthma. ( Ben Dov, I; Godfrey, S; Goldenberg, B; Springer, C, 1985) |
| "Nocturnal wheeze is common in patients with asthma, and slow release theophyllines may reduce symptoms." | 9.05 | Sustained release choline theophyllinate in nocturnal asthma. ( Connaughton, JJ; Douglas, NJ; Flenley, DC; McFie, J; Rhind, GB, 1985) |
| "The literature is unclear as to whether theophylline loading doses should be based on total body weight (TBW) or ideal body weight (IBW)." | 9.05 | Volume of distribution of theophylline in acute exacerbations of reversible airway disease. Effect of body weight. ( Curtis, RA; Fischer, JH; Troyer, WG; Zell, M, 1985) |
| "We studied the effect of oral terbutaline on serum theophylline levels in 12 children with asthma." | 9.05 | Reduction of serum theophylline levels by terbutaline in children with asthma. ( Danziger, Y; Garty, M; Ilfeld, D; Rosenfeld, JB; Varsano, I; Volwitz, B, 1985) |
| "The airway response to increasing concentrations of inhaled-adenosine and histamine after oral theophylline or matched placebo was studied in nine asthmatic subjects." | 9.05 | Specific antagonism of adenosine-induced bronchoconstriction in asthma by oral theophylline. ( Holgate, ST; Mann, JS, 1985) |
| "In 15 asthmatic children and 3 healthy adult volunteers the pharmacokinetics and pharmacodynamics of proxyphylline under oral treatment, and the pharmacokinetics after intravenous administration were determined." | 9.05 | [Pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children]. ( Kalla, M; Reinhardt, D; Richter, O, 1985) |
| "The bronchodilator effect of a 10 mg/kg dose of theobromine (3,7-dimethylxanthine) was compared with that of 5 mg/kg of theophylline (1,3-dimethylxanthine) in young patients with asthma." | 9.05 | The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma. ( Becker, AB; Gillespie, CA; Simons, FE; Simons, KJ, 1985) |
| "Nine adult subjects with perennial bronchial asthma participated in a single-blind, cross-over, placebo-controlled study to evaluate and compare the effectiveness of a 24-hour sustained-release theophylline formulation, Uniphyl, with that of a twice-daily compound, Theo-Dur." | 9.05 | Pharmacokinetics and clinical response to single- and multiple-dose sustained-release theophylline compounds in perennial bronchial asthma. ( Fanta, CH; McFadden, ER, 1985) |
| "The bronchodilator effects of 375 mg theophylline orally and 200 microg salbutamol by pressurized aerosol were compared in a randomized, cross-over, double-blind trial in fourteen asthmatic patients." | 9.04 | Comparison of oral theophylline and salbutamol by inhalation in asthmatic patients. ( Hartnett, BJ; Marlin, GE, 1976) |
| "28 children with chronic asthma (15 in Denver and 13 in London) completed a 12 wk double-blind trial of treatment with sodium cromoglycate (cromolyn sodium), theophylline, and a combination of both." | 9.04 | Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study. ( Bell, T; Cavanaugh, M; Ginchansky, E; Godfrey, S; Greenberg, S; Hambleton, G; Taylor, J; Tooley, M; Weinberger, M, 1977) |
| "12 patients with bronchial asthma received treatment with Ketotifen for three months." | 9.04 | [Ketotifen, a new prophylactic agent in asthma (author's transl)]. ( Fryda-Kaurimsky, Z; Giesen, HK, 1979) |
| "Sixteen asthmatic children between the ages of 7 and 13 years, 13 of whom were receiving theophylline orally around-the-clock, were studied for eight weeks in double-blind manner to evaluate efficacy, toxicity, and development of tolerance to the combination of ephedrine sulfate and theophylline." | 9.04 | Ephedrine therapy in asthmatic children. Clinical tolerance and absence of side effects. ( Avner, SE; Tinkelman, DG, 1977) |
| "The bioavailability, duration of action, and efficacy of a crystallized tablet form of theophylline were studied in 16 nonsteroid-dependent asthmatic children." | 9.04 | The effectiveness of the short- and long-term use of crystallized theophylline in asthmatic children. ( Katz, RM; Rachelefsky, GS; Siegel, S, 1978) |
| "In a double-blind, crossover study a sustained release theophylline preparation was found to be effective and safe while controlling the symptoms and improving the measured pulmonary function of 16 chronic childhood asthmatics." | 9.04 | A sustained release theophylline preparation: efficacy in childhood asthma with low serum theophylline levels. ( Katz, RM; Rachelefsky, GS; Siegel, SC, 1978) |
| "5 mg hydroxyzine hydrochloride were compared in a double-blind cross-over placebo-controlled study in 12 patients with chronic reversible bronchial asthma." | 9.04 | The efficacy of oral theophylline and the combination of theophylline + hydroxyzine in chronic bronchial asthma. ( Lahdensuo, A, 1978) |
| "11 asthmatic outpatients were treated with placebo, ephedrine + theophylline + hydroxyzine, ephedrine + theophylline, and ephedrine + hydroxyzine, orally t." | 9.04 | Objective and subjective assessment of ephedrine combinations in asthmatic outpatients. ( Mattila, MJ; Muittari, A, 1979) |
| "Exercise-induced bronchospasm was induced by treadmill running in 12 children on two days preceding either inhaled cromolyn sodium (Intal) or oral theophylline (Slo-Phyllin tablets), 7." | 9.04 | Relationship of serum theophylline concentration to inhibition of exercise-induced bronchospasm and comparison with cromolyn. ( Cooper, D; Kiechel, F; Pollock, J; Weinberger, M, 1977) |
| "A double-blind crossover trial was conducted in 10 asthmatic patients for comparison of fenoterol with salbutamol, in 12 other asthmatic patients for comparison of reproterol with salbutamol, and in 15 other asthmatic patients for comparison of terbutaline with salbutamol." | 9.04 | [The bronchospasmolytics salbutamol, fenoterol, terbutaline and reproterol. Their effects and side effects in asthmatics after inhalation with an electric nebulizer]. ( Budmiger, H; Kyd, K; Scherrer, M, 1978) |
| "Theophylline has been used for decades to treat both acute and chronic asthma." | 8.98 | Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis. ( Li, J; Mahemuti, G; Ren, L; Tieliwaerdi, N; Zhang, H, 2018) |
| "Intravenous theophyllines are a second line treatment for children suffering an acute exacerbation of asthma." | 8.93 | The Evidence for Intravenous Theophylline Levels between 10-20mg/L in Children Suffering an Acute Exacerbation of Asthma: A Systematic Review. ( Cooney, L; Hawcutt, D; Sinha, I, 2016) |
| "Addition of theophylline to ICS has similar therapeutic effects on improving lung function as increasing the dose of ICS in the treatment of symptomatic asthma." | 8.87 | Addition of theophylline or increasing the dose of inhaled corticosteroid in symptomatic asthma: a meta-analysis of randomized controlled trials. ( Liao, X; Lin, K; Wang, C; Wang, Y, 2011) |
| "Doxofylline, a methylxanthine derivative, has recently drawn attention because of its better safety profile and similar efficacy over the most widely prescribed analogue, theophylline, indicated for asthma and chronic obstructive pulmonary disease." | 8.85 | Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. ( Chakraborty, S; Mishra, B; Shukla, D; Singh, S, 2009) |
| "Theophylline and long acting beta-2 agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma." | 8.84 | Long-acting beta2-agonists versus theophylline for maintenance treatment of asthma. ( Gibson, PG; Irving, LB; Koh, MS; Lasserson, TJ; Tee, AK; Wilson, AJ, 2007) |
| "Mice rendered adenosine deaminase-deficient manifest an 'asthma' phenotype in the lungs that includes mast cell degranulation, eosinophilia, mucus hypersecretion and bronchial hyperresponsiveness." | 8.82 | The case for a role for adenosine in asthma: almost convincing? ( Fozard, JR, 2003) |
| "Theophylline and long acting beta-2 agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma." | 8.82 | Long acting beta-agonists versus theophylline for maintenance treatment of asthma. ( Coughlan, J; Gibson, PG; Shah, L; Wilson, AJ, 2003) |
| "Despite having been recognized for a long time as a cheap and effective therapy for the treatment of asthma and chronic obstructive pulmonary disease (COPD), theophylline is relegated to third-line therapy in the treatment of airway diseases due to the drug's frequent side effects and relatively low efficacy." | 8.82 | Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease. ( Barnes, PJ; Erin, EM; Hansel, TT; Higgins, LA; Neighbour, H; Tan, AJ; Tennant, RC, 2004) |
| "Theophylline has been reduced usage in asthma and chronic obstructive pulmonary disease because of the high frequency of side effects and the relatively low efficacy." | 8.82 | [Development of theophylline in treatment of asthma and chronic obstructive pulmonary disease]. ( Xu, YJ, 2004) |
| "These results indicated that the expression of A2bAR mRNAs in PBMCs was more remarkable in asthmatics than in healthy subjects; that adenosine or IL-1 potentiated the mRNA expression of A2bAR in PBMCs in asthmatic patients, which was correlated with allergy state and the degree of airway obstruction; and that theophylline might antagonize adenosine by inhibiting A2bAR mRNA." | 8.81 | [The effects of adenosine, interleukin-1 and theophylline on the expression of A2 adenosine receptor mRNAs in peripheral blood mononuclear cells from asthmatic patients]. ( Lin, Y; Wang, Z; Zhou, X; Zhu, Y, 2001) |
| "Many clinical trials have suggested that theophylline has anti-inflammatory properties in the treatment of bronchial asthma." | 8.80 | Asthma, adenosine, mast cells and theophylline. ( Church, MK; Coward, WR; Sagara, H, 1998) |
| "Low dose theophylline has been shown to reduce requirements for inhaled corticosteroid therapy in patients with asthma and may reduce overall treatment costs." | 8.80 | Theophylline. A review of its potential steroid sparing effects in asthma. ( Faulds, D; Markham, A, 1998) |
| "The use of theophylline for the treatment of asthma for 45 of the past 50 years has been for its ability to dilate bronchi." | 8.80 | Recent advances in our understanding of the use of theophylline in the treatment of asthma. ( Page, CP, 1999) |
| "Theophylline and long acting beta2-agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma." | 8.80 | Long acting beta-agonists versus theophylline for maintenance treatment of asthma. ( Coughlan, J; Gibson, PG; Wilson, AJ, 2000) |
| "Views on the appropriate use of theophylline in asthma management have varied substantially over the past decades." | 8.80 | The role of theophylline in asthma management. ( Kips, JC; Pauwels, RA; Peleman, RA, 1999) |
| "Current Japanese asthma guidelines recommend theophylline as an additional regimen to inhaled beta-agonists (on demand use) and inhaled corticosteroids (beclomethason dipropionate 200-1200 micrograms/day or fluticason propionate 200-800 micrograms/day) for patients whose asthma is not controlled completely." | 8.80 | Theophylline for the treatment of bronchial asthma: present status. ( Kato, M; Kawai, M, 2000) |
| "Theophylline has been in clinical use for the treatment of bronchial asthma and other respiratory diseases for well over 50 yrs." | 8.79 | Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma. ( Banner, KH; Page, CP, 1995) |
| "Theophylline has been used for several decades in the treatment of asthma and remains the most widely prescribed anti-asthma drug worldwide, although the development of newer anti-asthma medications, especially inhaled steroids, has resulted in declining use of theophylline in industrialized countries." | 8.79 | Theophylline in the management of asthma: time for reappraisal? ( Barnes, PJ; Pauwels, RA, 1994) |
| "The mechanism of action of theophylline in the treatment of asthma is not yet fully understood." | 8.79 | The changing role of theophylline in pediatric asthma. ( Stoloff, SW, 1994) |
| "An 8-year-old asthmatic child on theophylline was anesthetized with enflurane in nitrous oxide and oxygen." | 8.79 | [Myoglobinuria following anesthesia with enflurane and succinylcholine in an asthmatic child on theophylline]. ( Dan, K; Higa, K; Shono, S; Watanabe, R, 1996) |
| "Theophylline has traditionally been considered for its effect on airway calibre in the treatment of bronchial asthma." | 8.79 | Low-dose theophylline: a new anti-inflammatory role in asthma management? ( Djukanović, R; MacLeod, D, 1996) |
| "Although theophylline is a widely used drug for the treatment of acute childhood asthma, its efficacy has not been clearly established." | 8.79 | Theophylline in acute childhood asthma: a meta-analysis of its efficacy. ( Brooks, JG; Goodman, DC; Littenberg, B; O'Connor, GT, 1996) |
| "Theophylline and its derivatives have been used in the treatment of asthma for over 50 years, but since the advent of more potent bronchodilators their use has become cloaked in controversy." | 8.78 | Theophylline. Current thoughts on the risks and benefits of its use in asthma. ( Nasser, SS; Rees, PJ, 1993) |
| "A case of a 81-year-old asthmatic male with Theophylline-induced rhabdomyolysis was reported." | 8.78 | [A case of theophylline-induced rhabdomyolysis following therapy of bronchial asthma]. ( Aoshima, M; Kameyama, S; Kamiya, T; Miyazaki, T; Murai, Y; Yamazaki, M, 1991) |
| "Beta 2-agonists and theophylline compounds are first line drugs and are extensively used in the treatment of acute bronchial asthma." | 8.77 | Round table on antiasthmatic drugs; beta-agonists and theophylline. Workshop on pathogenesis and therapy of bronchial asthma Cortina d'Ampezzo/1-4 April, 1987. ( Boschetti, E; Grassi, V; Tantucci, C, 1989) |
| "In addition to its bronchodilating activity, the antiasthmatic drug theophylline also reduces microvascular permeability and increases mucociliary clearance, diaphragmatic contractility, and circulating catecholamine levels." | 8.77 | New aspects of the therapeutic potential of theophylline in asthma. ( Pauwels, RA, 1989) |
| "Despite widespread use of theophylline in the hospital management of asthma, supportive data justifying its use are sparse." | 8.77 | Is theophylline use justified in acute exacerbations of asthma? ( Abou-Shala, N; Amarshi, N; Ellis, RF; Self, TH, 1989) |
| "Recent reviews and editorials have indicated that theophylline may not be effective for the therapy of acute severe asthma." | 8.77 | Should we stop using theophylline for the treatment of the hospitalized patient with status asthmaticus? ( Kelly, HW; Murphy, S, 1989) |
| "In relation to antiasthmatic treatment of hospitalized patients with theophyllines, results concerning: a) a retrospective analysis of plasma levels observed over a 18-month period; b) a pharmacokinetic study and consequent determination of an efficient individual posology are reported." | 8.77 | [Importance of the laboratory in optimizing anti-asthma therapy with theophylline]. ( Snidero, M, 1987) |
| "Theophylline has demonstrated a very high degree of clinical efficacy as a prophylactic maintenance drug for chronic asthma when dose levels maintain serum concentrations of 10 to 20 micrograms/ml." | 8.77 | Therapeutic effect and dosing strategies for theophylline in the treatment of chronic asthma. ( Hendeles, L; Weinberger, M, 1986) |
| "The experimental data providing the rationale for the use of ketotifen as a prophylactic drug in asthma (inhibition of release of the mediators of anaphylaxis, particularly SRS-A, prevention of the bronchospasm induced by SRS-A in vivo, calcium antagonist effect) are briefly discussed, and the results of experimental and therapeutic trials carried out over 6 years in a number of countries in several thousand patients are reviewed." | 8.76 | Ketotifen in the oral prophylaxis of bronchial asthma: a review. ( Craps, L, 1981) |
| "The use of cromolyn sodium (SCG) and high-dose theophylline (HDT) in the treatment of chronic perennial asthma in children is reviewed." | 8.76 | The relative merits of cromolyn sodium and high-dose theophylline therapy in childhood asthma. ( Godfrey, S, 1980) |
| "Even with the availability of new and exciting antiasthmatic drugs, theophylline is emerging as one of the most useful noncorticosterioid agents available for suppressing symptoms in the patient with chronic asthma." | 8.76 | Experience with theophylline for the management of chronic asthma. ( Hendeles, L; Weinberger, M, 1980) |
| " These agents are useful by aerosol and oral routes, alone and in addition to theophylline for asthma." | 8.75 | Treatment of asthma with theophylline and beta adrenergic agents. ( Davis, WJ; Feldman, BR, 1976) |
| " Multivariable logistic or linear regression was used for the analysis of urinary levels of caffeine or each of its three major metabolites (paraxanthine, theobromine, and theophylline) and current asthma, lung function, and FeNO." | 8.12 | Urinary caffeine and caffeine metabolites, asthma, and lung function in a nationwide study of U.S. adults. ( Celedón, JC; Forno, E; Han, YY, 2022) |
| "Theophylline is commonly used for the treatment of asthma and has a low hepatic clearance." | 7.96 | Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach. ( Alanazi, MM; Alasmari, F; Alqahtani, F; Imran, I; Khalid, R; Majeed, A; Rasool, MF; Saeed, H, 2020) |
| "Both theophylline and doxofylline produced enhancements in PFT at different time intervals in both asthma and COPD patients." | 7.81 | Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease. ( Kumar, R; Lal, D; Manocha, S; Ray, A; Vijayan, VK, 2015) |
| " To investigate the pharmacokinetics of theophylline in the presence of pyrexia, patients were divided into two groups based on body temperature: a pyrexia group (> or = 38 degrees C) and a non-pyrexia group (< 38 degrees C)." | 7.78 | Influences of pyrexia and age on theophylline clearance in young children with asthma. ( Imai, K; Kihira, K; Kimura, Y; Mimaki, Y; Morita, T; Munehisa, Y; Nomura, H; Yoshikuni, Y, 2012) |
| "The objective of the present work was to develop a delayed-onset controlled-release colon-targeted system of theophylline, and to achieve the chronotherapy of nocturnal asthma." | 7.77 | Design and optimization of colon-targeted system of theophylline for chronotherapy of nocturnal asthma. ( Amin, AF; Patel, MM, 2011) |
| "The purpose of this research work was to develop and evaluate a chronotherapeutic based colon-targeted drug delivery system of theophylline (THEO) exploiting pH-enzyme sensitive property for the prevention of episodic attack of asthma in early morning." | 7.77 | pH-enzyme di-dependent chronotherapeutic drug delivery system of theophylline for nocturnal asthma. ( Dangi, JS; Dangi, YS; Gupta, M; Jain, SK; Kumar, M; Namdeo, KP; Soni, ML, 2011) |
| "Theophylline is commonly used to treat severe asthma and chronic obstructive pulmonary disease (COPD) characterized by non-eosinophilic inflammation." | 7.76 | Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma. ( Choi, DS; Choi, JP; Gho, YS; Jeon, SG; Kim, YK; Kim, YS; Moon, HG; Yoon, CM, 2010) |
| "To elucidate the mechanisms of intractable pediatric bronchial asthma and the indication of low-dose erythromycin (EM) therapy, the serum chemokine levels of and the angiogenic factor were evaluated in 55 pediatric patients with bronchial asthma; 7." | 7.76 | The indication and effectiveness of low-dose erythromycin therapy in pediatric patients with bronchial asthma. ( Akiyoshi, K; Izumi, T; Korematsu, S; Maeda, T; Miyahara, H; Nagakura, T; Okazaki, N; Suenobu, S; Yamamoto, K, 2010) |
| "Asthma is considered as the most relevant pulmonary disease which is located at bronchial airways and oral theophylline is one of the most prescribed drugs for its treatment as it is inexpensive." | 7.75 | Respiratory delivery of theophylline by size-targeted starch microspheres for treatment of asthma. ( Mohammadi, MH; Momeni, A, 2009) |
| "We report a case of theophylline-induced hypercalcemia." | 7.74 | [A case of theophylline induced hypercalcemia]. ( Itoh, Y; Kimura, T; Takeshita, Y; Tokita, Y; Toya, Y; Tsurumi, Y; Umemura, S, 2007) |
| "To study the effects of doxofylline on calcium-activated potassium (K(Ca)) channels of human peripheral blood eosinophils in asthma." | 7.73 | [Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma]. ( Cai, CQ; Cai, SX; Zhao, HJ; Zhou, B; Zou, F, 2005) |
| "Although viral infection might alter theophylline metabolism in acute asthma, there are some difficulties in detecting infection due to various kinds of viruses in a clinical setting." | 7.73 | Theophylline metabolism in acute asthma with MxA-indicated viral infection. ( Adachi, Y; Fuchizawa, T; Itazawa, T; Miyawaki, T; Murakami, G; Nakabayashi, M, 2006) |
| "Theophylline is a useful drug for the treatment of asthma." | 7.73 | A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD. ( Adachi, M; Fukuda, T; Kihara, N; Makino, S; Miyamoto, T; Nakajima, S; Nishima, S; Ohta, K, 2006) |
| " Theophylline possesses anti-inflammatory activities in asthma." | 7.72 | Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma. ( Chung, KF; Huang, KH; Kuo, HP; Lin, CH; Lin, HC; Liu, SL; Wang, CH; Yu, CT, 2003) |
| "Although theophylline has long been used as a medication for bronchial asthma (BA), much remains to be elucidated about its action on Th2 cells, which play a critical role in the development of BA." | 7.72 | Theophylline suppresses IL-5 and IL-13 production, and lymphocyte proliferation upon stimulation with house dust mite in asthmatic children. ( Kimura, M; Okafuji, I; Yoshida, T, 2003) |
| "A large-scale prospective study was conducted in 3810 Japanese elderly (> or =65 years old) patients with asthma or chronic obstructive pulmonary disease (COPD) who had been treated with sustained-release theophylline tablets (THEODUR) at a dose of 400 mg/day for 1-6 months, in principle." | 7.72 | A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD. ( Fukuchi, Y; Grouse, L; Mizutani, R; Ohta, K; Rabe, KF; Rennard, SI; Zhong, NS, 2004) |
| "To assay theophylline blood levels in a sample of Sri Lankan chronic asthmatics taking oral theophylline, and to evaluate a simple and cost effective ultraviolet spectrophotometric assay for theophylline levels in blood." | 7.71 | Theophylline blood levels in Sri Lankan asthmatics: comparison of two methods of assay. ( Balasuriya, WK; Cooray, HC; Fernando, N; Goonetilleke, AK; Munasinghe, TM, 2002) |
| "Metabolic and electrolyte abnormalities, including hypokalemia, hyperglycemia and lactic acidosis, are associated with theophylline overdose." | 7.71 | Lactic acidosis associated with the usual theophylline dose in a patient with asthma. ( Choi, IS; Koh, YI, 2002) |
| "We report a case of acute generalized exanthematous pustulosis (AGEP) in a 64-year-old woman, associated with the use of bamifylline." | 7.71 | Acute generalized exanthematous pustulosis induced by ingestion of bamifylline. ( Criado, PR; Criado, RF; de Mello, JF; Fernandes, MF; Galvão, C; Valente, NY, 2002) |
| ") administration of aminophylline has been used to relieve acute exacerbation of bronchial asthma for almost a century." | 7.71 | [Early replacement of intravenous aminophylline administration with oral theophylline in treating acute exacerbation of asthma]. ( Kamiya, U; Kondo, T; Moue, Y; Ohta, Y; Ono, Y; Syouyama, Y; Tanigaki, T; Tazaki, G, 2001) |
| "The comparative effects of a new theophylline preparation (Theodrip) and aminophylline on blood concentrations of theophylline were examined in 74 patients with asthma." | 7.71 | Comparative effect of theophylline and aminophylline on theophylline blood concentrations and peripheral blood eosinophils in patients with asthma. ( Kato, M; Morita, H; Okada, K; Sakamoto, K; Tatsuta, H, 2001) |
| "We examined effects of theophylline withdrawal in 17 adult asthmatics whose symptoms were well controlled under a treatment of a combination of theophylline and inhaled beclomethasone dipropionate (iBDP)." | 7.71 | Effects of theophylline withdrawal in well-controlled asthmatics treated with inhaled corticosteroid. ( Baba, K; Hattori, T; Kobayashi, T; Koishikawa, I; Niwa, S; Sakakibara, A; Takagi, K; Yagi, T; Yoshida, K, 2001) |
| "To investigate the mechanism of anti-inflammatory action of theophylline on asthma." | 7.71 | Effects of theophylline on CD4+ T lymphocyte, interleukin-5, and interferon gamma in induced sputum of asthmatic subjects. ( Hu, SP; Nie, HX; Wu, XJ; Yang, J, 2002) |
| "This study suggests that theophylline may be antiinflammatory by inhibiting the L-arginine-dependent production of NO in patients with asthma." | 7.70 | Theophylline inhibits the production of nitric oxide by peripheral blood mononuclear cells from patients with asthma. ( Bouboulis, D; Frieri, M; Matin, A; Sansone, GR; Wang, SF, 1998) |
| "A 53-year-old cocaine user was on chronic therapy with theophylline, albuterol, and ipratropium for asthma and nifedipine for hypertension." | 7.70 | Nonconvulsive status epilepticus in theophylline toxicity. ( Krieger, AC; Takeyasu, M, 1999) |
| "Hypercalcemia and hypercalciuria observed both in humans and in animals who were on long-term theophylline therapy, prompted us to investigate whether oral theophylline treatment at optimal doses causes any adverse side effects on bone metabolism in mild asthmatics." | 7.70 | Evaluation of the effect of low-dose oral theophylline therapy on some bone turnover markers and serum prolidase I activity in mild asthmatics. ( Büyüköztürk, S; Gürdöl, F; Kolanci, C; Oner, P; Oner-Iyidon, Y, 1999) |
| "The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP." | 7.70 | Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under. ( Arakawa, M; Arakawa, Y; Hayakawa, T; Imai, K; Iwata, T; Kizu, J; Komoda, F; Takamizawa, M, 1999) |
| " The aim of the present study was to investigate the role of adenosine A2b receptors in the anti-proliferative action of theophylline in human peripheral blood mononuclear cells (HPBMC) from healthy and asthmatic subjects." | 7.70 | The role of adenosine receptors in the action of theophylline on human peripheral blood mononuclear cells from healthy and asthmatic subjects. ( Jensen, MW; Landells, LJ; O'Connor, BJ; Orr, LM; Page, CP; Spina, D, 2000) |
| "Theophylline, a known phosphodiesterase inhibitor, has been widely used as an additional bronchodilator in asthmatic patients who are not adequately controlled on high-doses of inhaled steroids." | 7.70 | Theophylline induces a reduction in circulating interleukin-4 and interleukin-5 in atopic asthmatics. ( Baxevanis, CN; Kosmas, EN; Michaelides, SA; Polychronaki, A; Polychronopoulos, V; Roussou, T; Toukmatzi, S, 1999) |
| "We investigated changes in the circadian rhythm of peak expiratory flow (PEF) in seven persons with nocturnal asthma for a 24h span when (1) they were symptom free and their disease was stable, (2) their asthma deteriorated and nocturnal symptoms were frequent, and (3) they were treated with theophylline chronotherapy." | 7.70 | Circadian rhythm in peak expiratory flow: alteration with nocturnal asthma and theophylline chronotherapy. ( Burioka, N; Sako, T; Shimizu, E; Suyama, H, 2000) |
| "In order to study whether a theophylline-related seizure is caused by a decrease in serum vitamin B6, serum pyridoxal (PAL) levels were measured in children with bronchial asthma treated with theophylline." | 7.70 | [Depression of serum pyridoxal levels in theophylline-related seizures]. ( Furukawa, K; Hattori, H; Hayashi, K; Inada, H; Isshiki, G; Kobayashi, N; Matsuoka, O; Seto, T; Tada, H, 2000) |
| "To evaluate the potential inhibitory effect of theophylline on the pulmonary oxidative stress in asthma and chronic obstructive pulmonary disease (COPD), we concomitantly measured the blood levels of theophylline, a non-selective phosphodiesterase (PDE) inhibitor and lipid peroxides as an index of oxidative stress." | 7.70 | Evidence of oxidative stress in asthma and COPD: potential inhibitory effect of theophylline. ( Dobashi, K; Hisada, T; Iizuka, K; Ishizuka, T; Iwamae, S; Mori, M; Shimizu, Y; Tsukagoshi, H, 2000) |
| "To investigate the role of glucocorticosteroid and theophylline in treatment of asthmatic inflammation and their effects in production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS)." | 7.70 | [The role of glucocorticosteroid and theophylline in asthmatic inflammation of murine model and the inhibition in NO production in lung]. ( Gao, Z; He, Q; Yu, B, 1998) |
| "Oral theophylline treatment may be helpful in controlling severe asthma during pregnancy." | 7.69 | Slow-release theophylline in pregnant asthmatics. ( Riikonen, S; Stenius-Aarniala, B; Teramo, K, 1995) |
| "This study was undertaken to investigate the effect of theophylline on circulating vitamin B6 levels in children with asthma." | 7.69 | Theophylline attenuates circulating vitamin B6 levels in children with asthma. ( Maeda, S; Mochizuki, H; Morikawa, A; Shimizu, T; Tokuyama, K, 1994) |
| "We retrospectively evaluated three fluent asthmatic children who developed speech dysfluency following administration of theophylline." | 7.69 | Stuttering induced by theophylline. ( McCarthy, M; McKinney, K; Nudelman, HB; Rosenfield, DB; Viswanath, NS, 1994) |
| "This study was undertaken to investigate the effect of theophylline on serum uric acid levels in children with asthma." | 7.69 | Effect of theophylline on serum uric acid levels in children with asthma. ( Kuroume, T; Maeda, S; Mochizuki, H; Morikawa, A; Shimizu, T; Tokuyama, K, 1994) |
| "Theophylline has shown itself to be a useful bronchodilator in the treatment of asthma, although its use has been restricted of late due to its lesser potency and greater side effects when compared with beta-adrenergic inhalants." | 7.69 | [The usefulness of theophylline in the treatment of moderate-severe asthma]. ( Bazo Fernández, E; Cebollero Rivas, P; Colás Sanz, C; Duce Gracia, F; Garisa Rocha, R, 1994) |
| "Elevated serum levels of theophylline, a first-line anti-asthma drug, are sometimes associated with febrile respiratory infection (FRI)." | 7.69 | [Decreased theophylline clearance in children with acute asthma with concurrent febrile respiratory infection]. ( Asai, T; Ikegami, H; Kurosaki, T; Makino, K; Matsuka, Y; Ohta, F; Saitoh, Y; Tamai, K; Toba, T, 1994) |
| "Hypomagnesaemia in a woman treated with theophylline and albuterol because of recurrent asthmatic attacks prompted us to explore the effects of these drugs on the metabolism of magnesium, calcium, sodium and phosphate in such patients." | 7.69 | Intravenous theophylline-induced excretion of calcium, magnesium and sodium in patients with recurrent asthmatic attacks. ( Bøhmer, T; Falch, J; Knutsen, R, 1994) |
| "Although first-line therapy for bronchial asthma has changed over the past decade to anti-inflammatory medication such as inhaled corticosteroids and cromolyn with possible addition of beta-agonists, theophylline is still useful and therefore widely used." | 7.69 | [Therapeutic and toxic theophylline levels in asthma attacks--is there a need for additional theophylline?]. ( Fink, G; Fradin, Z; Gardyn, J; Mittelman, M; Zeidman, A, 1997) |
| "4, range: 2-12 years) with an acute asthma attack were treated by an intravenous dosage regimen of theophylline (30 min loading infusion of 6 mg/kg body weight followed by a constant infusion of 1 mg/kg, twice for 6 hr each)." | 7.69 | Disposition of intravenous theophylline in asthmatic children: Bayesian approach vs direct pharmacokinetic calculations. ( el Desoky, E; Ghazal, MH; Klotz, U; Mohamed, MA, 1997) |
| "To evaluate the relationship of psychologic function of severely asthmatic children and families with theophylline compliance during a 1-year follow-up period after inpatient asthma rehabilitation." | 7.69 | Maintaining theophylline compliance/adherence in severely asthmatic children: the role of psychologic functioning of the child and family. ( Faust, D; Weinstein, AG, 1997) |
| "Several lines of evidence support the hypothesis that adenosine contributes to asthma." | 7.69 | Role of adenosine in asthma. ( Biaggioni, I; Feoktistov, I, 1996) |
| "The effect of intravenous theophylline upon the activity of creatinine kinase (CK) and its cardiac specific isoenzyme compound (CK-MB) and the frequency of cardiac arrhythmias was evaluated in 12 patients with bronchial asthma and spastic bronchitis." | 7.68 | [Effect of intravenous infusions of theophylline on cardiac arrhythmias and activity of creatinine kinase CK-MB in patients with airway obstruction]. ( Chazan, R; Droszcz, W; Eneser, M; Karwat, K; Tadeusiak, W; Tymińska, K, 1993) |
| "A 32 year old pregnant woman who had taken large doses of theophylline for asthmatic attack was brought to our emergency medical center with convulsion and respiratory disturbance." | 7.68 | [Severe theophylline toxicity in a pregnant asthmatic patient]. ( Kasagawa, J; Nagahama, H; Nagano, K; Seki, I; Suzuki, Y; Yamanaka, I, 1993) |
| "Eleven diurnally active asthma patients having a history of nocturnal asthma and treated regularly with albuterol or metaproterenol alone or with twice-daily sustained-release theophylline were evaluated for day-night pattern in peak expiratory flow (PEF) and use of supplemental beta-agonist aerosol for relief of acute asthma." | 7.68 | Day-night variation of airways status in sympathomimetic- and theophylline-treated asthma patients. ( Brown, AC; D'Alonzo, GE; Smolensky, MH, 1993) |
| "The effects of theophylline on allergen-induced airway obstruction and bronchial hyperresponsiveness were investigated in allergic rabbits." | 7.68 | Modification of allergen-induced airway obstruction and bronchial hyperresponsiveness in the allergic rabbit by theophylline aerosol. ( Ali, S; Metzger, WJ; Mustafa, SJ, 1992) |
| "We have shown previously that neutrophils (PMNs) from patients with asthma have a more potent stimulated respiratory burst than normals and that their respiratory burst is significantly less suppressed with exposure to 2-chloroadenosine (2-CADO)." | 7.68 | Neutrophils from asthmatics exhibit diminished responsiveness to 2-chloroadenosine which is reversed by theophylline. Evidence for a cyclic-AMP-independent pathway on human neutrophils. ( Borish, L; Joseph, BZ; Sustiel, AM, 1992) |
| "Oral beta-stimulants, theophylline and oral antiallergic drugs are frequently used for asthma treatment in Japan." | 7.68 | [Necessity and limitations of effectiveness of oral beta-stimulants, theophylline and oral antiallergic drugs in asthma treatment]. ( Igarashi, T; Komuta, K; Maeda, K, 1992) |
| "Possible cytogenetic effects of theophylline have been investigated in asthmatic patients undergoing continuous therapy with this drug." | 7.68 | Cytogenetic study in peripheral blood lymphocytes from asthmatic patients receiving continued therapy with theophylline. ( Bernal, ML; Broto, A; Duce, F; Martinez-Berganza, A; Sinues, B; Suarez, MA, 1992) |
| " The serum protein binding of theophylline was studied in 28 asthmatics and 11 patients with cystic fibrosis (CF) who were receiving the drug regularly." | 7.68 | Variability of the serum protein binding of theophylline in patients with asthma and cystic fibrosis. ( Blanchard, J; Harvey, S; Morgan, WJ, 1992) |
| "Several reports have been published on the disposition of methotrexate (MTX) when given in low dosages, but none in asthmatic patients." | 7.68 | Pharmacokinetics of low-dose methotrexate in adult asthmatics. ( Cochran, JE; Cott, GR; Erzurum, SC; Glynn-Barnhart, AM; Leff, JA; Martin, RJ; Szefler, SJ, 1992) |
| "A study was made of purine receptors (PR) in healthy subjects and bronchial asthma (BA) patients before and after theophylline (TP) treatment." | 7.68 | [The effect of theophylline on purine receptor function in bronchial asthma patients]. ( Belousov, IuB; Bondareva, GP; Dukhanin, AS; Omel'ianovskiĭ, VV; Sergeev, PV, 1992) |
| "Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients." | 7.68 | Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients. ( Arnaud, A; Bruguerolle, B; Philip-Joet, F; Reynaud, M, 1992) |
| "Academic achievement among children with asthma, at least those whose status is closely monitored in a structured treatment program, generally appears to be unaffected by asthma or by its treatment with appropriate doses of theophylline." | 7.68 | Does asthma or treatment with theophylline limit children's academic performance? ( Frasher, R; Lindgren, S; Lokshin, B; McCubbin, M; Nassif, E; Stromquist, A; Weinberger, M, 1992) |
| "Theophylline levels in stimulated and unstimulated mixed saliva were compared with total and free (unbound) serum theophylline levels in 11 outpatients with cystic fibrosis (CF) who were using theophylline regularly." | 7.68 | Relationship between serum and saliva theophylline levels in patients with cystic fibrosis. ( Blanchard, J; Harvey, S; Morgan, WJ, 1992) |
| "For the purpose of a safe and effective use of theophylline in therapy during an attack of asthma, we have examined the effect of an attack of bronchial asthma on the metabolism of theophylline." | 7.68 | [Examination of theophylline pharmacokinetics during an attack of bronchial asthma in children]. ( Odajima, Y, 1992) |
| "Seven children from 3 to 14 years old with chronic steroid-dependent asthma were treated with methotrexate (MTX)." | 7.68 | Methotrexate treatment of severe asthma in children. ( Guss, S; Portnoy, J, 1992) |
| "Lipid profiles were determined in three groups of children: children with asthma receiving long-term therapy with slow-releasing theophylline, children with asthma not treated with theophylline, and a control group of children without asthma." | 7.68 | Lipoprotein profile of children with asthma receiving long-term theophylline therapy: a preliminary study. ( Bearman, JE; Shahak, E; Shany, S; Tal, A; Yagupsky, P; Zuili, I, 1992) |
| "The effects of three different dosage schedules for sustained-release theophylline (Theolong) were investigated in children with asthma." | 7.68 | Plasma theophylline concentrations and airway function in asthmatic children receiving standard and modified RTC therapy. ( Arakawa, H; Kato, M; Kimura, T; Kuroume, T; Morikawa, A; Shigeta, M; Tateno, K, 1992) |
| "In order to clarify whether repirinast, an inhibitor of chemical mediator release, could influence the pharmacokinetics of theophylline, a loading test using intravenous injection of aminophylline was performed in 10 subjects with bronchial asthma before and after treatment with 300 mg/day of repirinast." | 7.68 | [The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma]. ( Dohi, Y; Houya, I; Kiuchi, H; Nagata, M; Sakamoto, Y; Tabe, K; Yamamoto, K, 1991) |
| " Theophylline is commonly used to relieve symptoms of chronic asthma." | 7.68 | Theophylline therapy inhibits neutrophil and mononuclear cell chemotaxis from chronic asthmatic children. ( Cambiucci, EC; Condino-Neto, A; De Nucci, G; Guglielmi, AA; Magna, LA; Ribeiro, JD; Vilela, MM, 1991) |
| "Theophyllines continue to have a definite place in asthma therapy." | 7.68 | The role of theophyllines in a preventive approach for subjects with both mild and severe asthma. ( Arkinstall, WW, 1991) |
| "Theophylline is used as a prophylactic agent for controlling bronchospasm in patients with asthma." | 7.68 | [A case of sustained-release theophylline (Theodur)-induced asthma]. ( Kitada, O; Kurusu, M; Nakamura, H; Nishioka, Y; Suenaga, N; Sugita, M, 1991) |
| "The steady-state population pharmacokinetics of theophylline were studied in 52 asthmatic adult patients who received sustained-release theophylline as armophylline or euphylline." | 7.68 | Steady-state population pharmacokinetics of sustained release theophylline in adult asthmatic patients. ( Gervais, P; Houze, P; Koen, R; Lagier, G; Thomas, G, 1991) |
| " Theophylline disposition was studied in 70 asthmatic adolescents, ages 8-18 years, to determine if pubertal changes in body size, composition, and organ function are associated with changes in drug disposition." | 7.68 | Theophylline disposition in adolescents with asthma. ( Cary, J; Dell, R; Hein, K, 1991) |
| "A retrospective descriptive analysis of 140 asthmatic patients, classified in our hospital as corticosteroid dependent and treated in outpatients departments showed, that 63% received slow release theophylline (SRT)." | 7.68 | [Prednisolone-dependent asthma patients--often under-treated in ambulatory care? Results of a retrospective study]. ( Förster, R, 1991) |
| "Troleandomycin has been reported to be useful for reducing the steroid requirement of patients with asthma." | 7.68 | Use of troleandomycin as a steroid-sparing agent in both asthma and chronic obstructive pulmonary disease. ( Cash, M; Shivaram, U, 1991) |
| "The long-term stability of morning serum theophylline concentrations (STC) and peak expiratory flow (PEF) was investigated for at least one year in 21 asthmatic patients who received individualised theophylline doses in addition to a baseline medication (beta 2-agonists, corticosteroids, anticholinergics by MDI)." | 7.68 | [Long-term stability of morning serum theophylline level in asthma patients under minimally 1-year therapy with Euphylong]. ( Böhm, A; Kunkel, G; Siebert, B; Staudinger, HW; Steinijans, VW, 1991) |
| "The effects of prednisolone, salbutamol or theophylline treatment were studied in guinea pigs on bronchial hyperreactivity induced by chronic administration of PAF, (subsequently measuring respiratory flow after an intravenous injection of histamine) and the chemokinesis of leucocytes in vitro." | 7.68 | Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs. ( Berga, P; Fernández, AG; Gristwood, RW; Llupiá, J, 1991) |
| "Theophylline levels in mixed saliva (both stimulated and unstimulated) were compared with total and free (unbound) serum theophylline levels in 28 asthmatic outpatients using theophylline regularly." | 7.68 | Serum/saliva correlations for theophylline in asthmatics. ( Blanchard, J; Harvey, S; Morgan, WJ, 1991) |
| "Total and free theophylline concentrations were examined by fluorescent immunoassay using serum from 48 asthmatic patients treated with sustained-release theophylline formulation." | 7.68 | [Studies of free theophylline in asthmatic patients]. ( Doi, S; Hattori, H; Hayashida, M; Inoue, T; Kishimoto, S; Takamatsu, I; Toyoshima, K; Yasunami, J, 1991) |
| "To examine the effects of serum theophylline concentration on the bronchodilating effect of beta 2-stimulant inhalated by patients with bronchial asthma, 200 micrograms-Salbutamol inhalation test was performed on 30 patients with bronchial asthma (from 17 to 71 years old, averaging 49." | 7.68 | [The influence of serum theophylline concentration on the bronchodilating effect of salbutamol inhalation for bronchial asthma]. ( Hashimoto, T; Kondo, A; Nakamata, M; Tsukioka, K, 1990) |
| "The dependence of the renal excretion of theophylline on its plasma concentration and urine flow rate has been investigated in asthmatic children of either sex." | 7.68 | Dependence of the renal excretion of theophylline on its plasma concentrations and urine flow rate in asthmatic children. ( Agbaba, D; Pesić, V; Pokrajac, M; Varagić, VM, 1990) |
| "We studied the steroid-sparing effect of dapsone in 10 subjects with chronic asthma in a preliminary open trial." | 7.68 | The effect of dapsone in steroid-dependent asthma. ( Berlow, BA; Dyer, Z; Liebhaber, MI; Spiegel, TM, 1991) |
| "In order to investigate the mechanism of adenosine-induced bronchoconstriction in asthma, serum neutrophil chemotactic activity (NCA) was measured in normal individuals and patients with asthma before and 5 min after bronchoprovocation testing with adenosine." | 7.68 | Bronchial challenge with adenosine causes the release of serum neutrophil chemotactic factor in asthma. ( Driver, AG; Kukoly, CA; Metzger, WJ; Mustafa, SJ, 1991) |
| "We studied the role of theophylline on outcome of status epilepticus (SE) in children." | 7.68 | Theophylline and status epilepticus in children. ( Dunn, DW; Parekh, HU, 1991) |
| "This study examined the relationship between long-term theophylline therapy and behavior problems in 14 asthmatic children that includes 5 intractable cases and 24 non-asthmatic children." | 7.68 | [Clinical effects of theophylline in the therapy of intractable asthmatic children. II. Theophylline therapy and behavior problems in children with asthma]. ( Iikura, Y; Segawa, H, 1990) |
| "The effect of menstrual cycle on the pharmacokinetics of theophylline has been studied in 9 female asthmatic patients." | 7.68 | Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics. ( Bruguerolle, B; Faraj, F; Razzouk, H; Toumi, M; Vervloet, D, 1990) |
| "Unstimulated saliva, citric acid stimulated saliva, and serum were collected from 31 asthmatic children taking theophylline." | 7.68 | Comparison of unbound and total serum theophylline concentrations with those of stimulated and unstimulated saliva in asthmatic children. ( Ben-Aryeh, H; Colin, AA; Gozal, D; Laufer, D; Siegel, IA; Szargel, R, 1990) |
| "The effect of ozagrel (OKY-046), a selective thromboxane A2 synthetase inhibitor, on theophylline disposition was studied in 12 asthmatic patients." | 7.68 | Effect of ozagrel (OKY-046), a thromboxane synthetase inhibitor, on theophylline pharmacokinetics in asthmatic patients. ( Kawaguchi, H; Kawakatsu, K; Kino, T; Oshima, S; Satake, N; Tsubata, R; Yasuba, H, 1990) |
| "The effect of an oral anti-allergic drug, mequitazine, on the pharmacokinetics of theophylline has been investigated in seven asthmatic patients." | 7.68 | Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients. ( Apichartpichean, R; Hasegawa, T; Kuzuya, T; Muraoka, I; Nadai, M; Takagi, K, 1990) |
| "Sustained-release theophylline (SRT) therapy was monitored in ambulatory children with asthma by measuring theophylline in citric acid-stimulated saliva." | 7.68 | Variations in theophylline concentrations detected by 24-hour saliva concentration profiles in ambulatory children with asthma. ( Aviram, M; Gorodischer, R; Tal, A, 1990) |
| "Our study was designed to assess potential cardiovascular adverse effects in clinically stable asthmatic children due either to oral sustained-release theophylline or theophylline in combination with an inhaled beta-2 adrenergic agonist." | 7.68 | Lack of adverse cardiac effects of combined treatment with theophylline and albuterol in asthmatic children. ( Bastianon, V; Bernardini, L; Businco, L; Coletta, F; Colloridi, V; Di Fazio, A; Ferrucci, A; Marzano, MC; Pucci, S; Sorbara, N, 1990) |
| "Theophylline binding to plasma protein was studied with seven bronchial asthmatic inpatients." | 7.67 | Clinical evaluation of theophylline binding to plasma protein in bronchial asthmatic patients. ( Hasegawa, M; Hasegawa, T; Johno, I; Kitazawa, S; Ogura, Y; Satake, T; Takagi, K; Yokochi, Y, 1984) |
| "Serum theophylline clearance was estimated prior to reaching steady state in 29 asthmatic children, aged 1-14 years, using methods described by Chiou et al." | 7.67 | Rapid estimation of serum theophylline clearance in children with acute asthma. ( Brown, AL; Kearns, GL; Kluza, RB; McConnell, RF; Stillwell, PC; Trang, JM; Wells, TG, 1984) |
| "The pharmacokinetic profiles of three oral sustained-release theophylline preparations in steady state (350 mg Theograd, 350 mg Theolair Retard [= Nuelin Retard], and 300 mg Theolin Retard [= Theodur]) were compared in a group of six normal subjects and six patients with moderately severe asthmatic bronchitis." | 7.67 | Pharmacokinetics and pharmacodynamics of three sustained-release theophylline preparations (350 mg Theograd, 350 mg Theolair Retard and 300 mg Theodur) in steady state in healthy volunteers and asthmatics--Part I: Theophylline plasma levels. ( Drost, RH; Kreukniet, J; Maes, RA; van der Vet, AP, 1984) |
| "Twenty-seven asymptomatic asthmatic children with airway obstruction received a single oral dose of one out of three solutions, in a double-blind, randomized fashion, containing: etamiphylline, 6." | 7.67 | [Comparative study of the effect of a single oral dose of theophylline and etamiphyllin in children with asthma]. ( Labayru, MT; Vázquez, C, 1984) |
| "A 61 year-old male patient developed gynecomastia after starting theophylline." | 7.67 | Gynecomastia associated with theophylline. ( Dardick, KR, 1984) |
| "To investigate serum theophylline levels during acute attacks of asthma, venous blood samples were taken from 41 consecutive patients." | 7.67 | Serum theophylline during acute asthmatic attacks. ( Tønnesen, J, 1984) |
| "We compared the bronchodilator effects and pharmacokinetics of orally administered caffeine (10 mg per kilogram of body weight) and theophylline (5 mg per kilogram) in a double-blind, single-dose study in asthmatic patients 8 to 18 years of age." | 7.67 | The bronchodilator effects and pharmacokinetics of caffeine in asthma. ( Becker, AB; Gillespie, CA; Simons, FE; Simons, KJ, 1984) |
| "Inhaled adenosine causes bronchoconstriction in asthmatic patients." | 7.67 | Adenosine-induced bronchoconstriction in asthma. Antagonism by inhaled theophylline. ( Cushley, MJ; Holgate, ST; Tattersfield, AE, 1984) |
| "The purpose of the study were to investigate the cardiopulmonary adaptations of asthmatic children to physical exercise and to evaluate the effects of theophylline." | 7.67 | Cardiopulmonary responses of asthmatic children to strenuous exercise. Effect of theophylline. ( Chryssanthopoulos, C; Gallen, WG; Hause, LL; Maksud, MG, 1984) |
| "A possible pharmacokinetic interaction between theophylline and repirinast has been investigated in asthmatic patients." | 7.67 | Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients. ( Apichartpichean, R; Hasegawa, T; Horiuchi, T; Kuzuya, T; Nadai, M; Ogura, Y; Takagi, K, 1989) |
| "We report a case of respiratory arrest in a ten-year-old asthmatic girl under beta-2-agonists and theophylline." | 7.67 | [Respiratory arrest in an asthmatic girl treated with beta-2-mimetics and theophylline. Possible role of hypokalemia in sudden death in asthmatic patients]. ( Benhamou, PH; Devoldere, C; Epelbaum, S; Kremp, O; Pautard, JC; Piussan, C, 1989) |
| "Aminophylline administration was compared in 43 patients who died from asthma and 43 matched controls who were admitted, suffering from acute asthma, to hospitals in the North East Thames Region." | 7.67 | Aminophylline toxicity--how many hospital asthma deaths does it cause? ( Eason, J; Markowe, HL, 1989) |
| "Theophylline serum levels were studied after oral administration of slow release theophylline (Talofilina) in children with bronchial asthma." | 7.67 | Theophylline serum levels in children with bronchial asthma after administration of slow release theophylline as open or closed capsules. ( Naspitz, CK; Solé, D, 1989) |
| "The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children." | 7.67 | Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. ( Garg, SK; Kumar, L; Lal, R; Shukla, VK; Singh, S, 1989) |
| "The bronchodilating effect of theophylline was studied from the perspective of its influence on the severity of acute asthmatic attack and where its acting site is located on bronchi." | 7.67 | Effect of theophylline on improvement of the pulmonary function in the treatment of acute episodes of asthma: the influence of the severity of acute asthma. ( Horai, Y; Kabe, J; Sakamoto, Y, 1989) |
| "In 27 cases of acute severe asthma, a loading dose of 5 mg/kg of aminophylline (omitted if already receiving oral theophylline) followed by a continuous infusion of 1 mg/kg per hour gave satisfactory theophylline levels at 4 h and 24 h." | 7.67 | Aminophylline dosage in acute severe asthma. ( Gleeson, JG; Price, JF, 1989) |
| "A 9-year-old boy developed Stevens-Johnson syndrome after taking slow-release theophylline for bronchial asthma." | 7.67 | Development of severe Stevens-Johnson syndrome after administration of slow-release theophylline. ( Brook, U; Fried, D; Singer, L, 1989) |
| "The pharmacokinetics of theophylline in serum and saliva, and the pulmonary functions were examined in seven asthmatic children aged 9-14 years in both single (6." | 7.67 | [Pharmacokinetics and pharmacodynamics of sustained-release theophylline formulation, Slo-bid, in both single and multiple dosing studies of asthmatic children]. ( Baba, M; Iwasaki, E, 1989) |
| "We often see severe asthma attacks occur in patients taking high doses of theophylline and disappear soon after intravenous injection of aminophylline." | 7.67 | [Asthma patients requiring unusually high doses of theophylline]. ( Matsumura, Y; Nakamura, T; Otsuka, H; Shiga, M; Sugiyama, H; Tomoe, Y, 1989) |
| "Plasma theophylline levels (mcg/ml) of 93 patients with a bronchopulmonary disease (asthma and chronic obstructive lung disease) who were on theophylline (normal or retarded) treatment, were determined on admission at the emergency ward because of acute bronchospasm." | 7.67 | [Levels of blood theophylline in patients with acute bronchospasm]. ( García Delgado, R; García Morillas, M; Martínez, B; Martínez, MJ; Puche, E; Saucedo, R, 1989) |
| "Theophylline, despite its potential for causing gastrointestinal tract and central nervous system side effects, is still the major drug used to control symptoms of moderate asthma in children." | 7.67 | Theophylline: is it obsolete for asthma? ( Rooklin, A, 1989) |
| "We monitored 14 asthmatic subjects (aged 18 to 60 years), with multiple 24-hour electrocardiogram (Holter) recordings, who were taking continuous sustained-release theophylline and beta-2-adrenergic therapy for control of their symptoms." | 7.67 | Lack of significant arrhythmogenicity from chronic theophylline and beta-2-adrenergic combination therapy in asthmatic subjects. ( Kelly, HW; Menendez, R; Voyles, W, 1985) |
| "Serum theophylline levels were measured in response to a single daily dose of Uniphyl in asthmatic adults who had previously received sustained-release theophylline preparations (usually Theo-Dur)." | 7.67 | Theophylline levels and clinical response in asthmatic adults receiving long-term Uniphyl. ( Petty, TL; Rollins, DL, 1985) |
| "It is widely believed that theophylline is a valuable addition to beta-agonists in the treatment of asthma." | 7.67 | Aminophylline in acute asthma. ( Olson, LG, 1987) |
| "The rate of ethanol elimination and blood acetate concentrations after a peroral dose of alcohol were measured in eight asthmatic patients receiving high-dose corticosteroid, sustained release theophylline and beta-2-sympathicomimetic treatment and in eight nonalcoholic, healthy controls." | 7.67 | Increased rate of ethanol elimination and elevated blood acetate in asthmatics on corticosteroid, beta-2-sympathicomimetic and theophylline treatment. ( Korri, UM; Salaspuro, M, 1988) |
| "Twelve children with chronic asthma were treated with a single dose of sustained-release theophylline once-a-day taken after supper at 9 PM." | 7.67 | Theophylline levels after single daily and divided dosing of a once-a-day theophylline preparation in asthmatic children. ( Boner, AL; Messori, A; Plebani, M; Sette, L; Vallone, G, 1989) |
| "Extrinsic asthmatic patients have been reported to have a deficiency of concanavalin A (Con A)-induced suppressor cell function." | 7.67 | Effect of in vitro colchicine and oral theophylline on suppressor cell function of asthmatic patients. ( Feierman, E; Ilfeld, D; Kivity, S; Kuperman, O; Topilsky, M, 1985) |
| "T-cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy." | 7.67 | Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children. ( Colin, AA; Horenstien, L; Lahat, N; Nir, E, 1985) |
| "Twenty patients with bronchial asthma, on long-term oral therapy with theophylline, demonstrated an increased number of suppressor T-cells and impaired graft vs host reaction." | 7.67 | Theophylline-induced alterations in cellular immunity in asthmatic patients. ( Fink, G; Mittelman, M; Shohat, B; Spitzer, SA, 1987) |
| "A group of 10 patients with chronic asthmatic bronchitis was titrated with slow-release theophylline (Theolin Retard) to a steady state plasma theophylline level of 10 mg/l." | 7.67 | Pharmacodynamics (lung function tests, tremor measurements and cAMP determinations) of a single dose of 0.5 mg terbutaline subcutaneously during sustained-release theophylline medication in patients with asthmatic bronchitis. ( Drost, RH; Fokkens, JK; Hamelink, ML; Kreukniet, J; Maes, RA; van der Vet, AP, 1986) |
| "Five asthmatic children (2 to 5 years) with persistent crying-induced bronchospasm refractory to concomitant oral theophylline and metaproterenol for 4 weeks were selected for an 8-week uncontrolled study with nebulized metaproterenol 5% and sodium cromoglycate 1%." | 7.67 | Crying-induced bronchospasm in childhood asthma: response to nebulized metaproterenol 5% and sodium cromoglycate 1%. ( Weinstein, AG, 1986) |
| "We developed an individualized approach for determining the intravenous rate of theophylline infusion for the treatment of status asthmaticus in children." | 7.67 | The use of theophylline clearance in pediatric status asthmaticus. II. The choice of appropriate dose for the intravenous theophylline infusion. ( Kolski, GB; Levy, J, 1987) |
| "The volume of distribution (Vd) of theophylline and the relevant aminophylline loading dose (LD) are usually calculated on the basis of total body weight (TBW)." | 7.67 | Effect of body weight on the volume of distribution of theophylline. ( Bonanno, A; Mirabella, A; Rizzo, A, 1988) |
| "Ambulant continuous intravenous theophylline therapy was used in a patient with frequent and severe asthmatic attacks." | 7.67 | Continuous intravenous therapy with theophylline in a patient with brittle bronchial asthma. ( Speelberg, B; van den Brink, WT, 1988) |
| "A pharmacokinetic model was applied to achieve therapeutic serum theophylline concentrations rapidly in 25 children with status asthmaticus." | 7.67 | Prediction of intravenous theophylline dosage based on a single, nonsteady-state concentration: a clinical study of childhood status asthmaticus. ( Anderson, DA; Kurland, G; Marquardt, ED; Mitsuoka, JC, 1988) |
| "A total of 42 children, aged from 5 to 13, all having been diagnosed as extrinsic asthma cases, were observed with the aim of establishing the average dose needed to maintain serum concentration by means of the administration of a slow-release theophylline preparation." | 7.67 | [Slow-release theophyllines: serum and saliva levels in asthmatic children]. ( Alvarez Sanz, E; Díaz Gómez, MI; Duque Hernández, J; Galván Tudela, L; Souto Martínez, I, 1988) |
| "The aim of the study was to determine whether gastro-oesophageal (GO)-reflux was increased by normal maintenance doses of theophylline, and if so, whether this was detrimental to lung function in asthmatic patients with symptoms of reflux." | 7.67 | Influence of theophylline on gastro-oesophageal reflux and asthma. ( Ekström, T; Tibbling, L, 1988) |
| "Theophylline absorption was studied in asthmatic children ages 2-7 years." | 7.67 | The consistency of theophylline absorption from a sustained-release formulation in asthmatic children. ( Haltom, JR; Hill, M; Szefler, SJ, 1988) |
| "To study whether theophylline inhibits airway hyperresponsiveness in a dose-dependent fashion, we performed inhalation challenges with histamine and methacholine in 9 asthmatic patients." | 7.67 | Theophylline has a dose-related effect on the airway response to inhaled histamine and methacholine in asthmatics. ( Jörres, R; Magnussen, H; Reuss, G, 1987) |
| "Fifteen Chinese subjects with stable asthma were given asymmetric doses of slow-release choline theophyllinate (Theobret) according to body weight; patients under 60 kg (132 lb) received 180 mg at 9 AM and 360 mg at 9 PM for six days (period 1), followed by 180 mg at 1 PM and 360 mg at 9 PM for six days (period 2); for those over 60 kg, the regimen was the same, except that they received 270 mg during the daytime and 540 mg at night." | 7.67 | The pharmacokinetics and efficacy of slow-release theophylline with asymmetric dosing in asthmatic Chinese. ( Pang, JA; Swaminathan, R; Zhang, YG, 1988) |
| "To explore the possibility that theophylline may act through adrenomedullary secretion of catecholamines, we examined the time courses of plasma norepinephrine (NE), epinephrine (E), and theophylline concentrations and peak expiratory flow (PEF) in nine children with an acute exacerbation of asthma receiving a 72-hour constant infusion of aminophylline." | 7.67 | Plasma catecholamine concentrations during a 72-hour aminophylline infusion in children with acute asthma. ( Ishizaki, T; Kanagawa, S; Minegishi, A; Morishita, M; Nagai, T; Odajima, Y; Yamaguchi, M, 1988) |
| "The purpose of this study was to evaluate prospectively the occurrence of cardiac arrhythmias during the combined therapy with intravenous aminophylline and terbutaline in 29 consecutive patients with status asthmaticus." | 7.67 | Cardiac arrhythmias during the combined use of intravenous aminophylline and terbutaline in status asthmaticus. ( Chauvet, JP; Iung, B; Laaban, JP; Proteau, J; Psychoyos, I; Rochemaure, J, 1988) |
| " The free and total plasma and saliva concentrations of theophylline were measured during a dosing interval at steady state in nineteen asthmatic subjects receiving a once-daily theophylline preparation (Riker TCR-1)." | 7.67 | Determinants of free theophylline clearance in asthma. ( Alwazir, YA; Buss, DC; Campbell, IA; John, R; Lazarus, JH; Littley, M; Routledge, PA; Williams, PE, 1987) |
| "Pharmacokinetic studies of theophylline were carried out in 12 Thai asthmatic children after oral administration of Elixir Quibron and Tablet Aminophylline." | 7.67 | Pharmacokinetics of oral theophylline in Thai asthmatic children. ( Geadsomnuig, S; Habananada, S; Koysooko, R; Pinthong, T; Tuchinda, M; Wattanapermpool, J, 1987) |
| "Intravenous administration of theophylline for acute asthmatic attacks treatment requires statistical adjustment of the dosage." | 7.67 | [Intravenous theophylline in the treatment of asthma attacks]. ( Blaive, B; Bonnaud, F; Clary, C; Lemoigne, F, 1987) |
| "An improved protocol was developed for the use of troleandomycin (TAO) in severe, steroid-requiring subjects with asthma." | 7.67 | An improved protocol for the use of troleandomycin (TAO) in the treatment of steroid-requiring asthma. ( Farr, RS; Friedman, BF; Wald, JA, 1986) |
| "The purpose of this study was to determine the dose requirements and dose interval of a sustained-release theophylline sprinkle preparation (Somophyllin-12) necessary to maintain therapeutic serum theophylline concentrations in children with asthma." | 7.67 | Evaluation of a sustained-release theophylline product in children with asthma. ( Amaro-Galvez, R; Aranda, J; Canny, GJ; Chua, YY; Fox, Z; Levison, H; Misener, C; Woo, N, 1987) |
| "Relationships between theophylline concentrations in saliva and serum and lung functions were investigated in 27 asthmatic children receiving a sustained-release theophylline." | 7.67 | Saliva and serum theophylline concentration in management of asthma in children on sustained-release therapy. ( Baba, M; Iwasaki, E, 1987) |
| "The efficacy of maintenance theophylline therapy at serum concentrations ranging between 8 and 20 micrograms/ml was studied over a six-month period in a group of 100 outpatients (age range 18-80 years) with chronic asthma." | 7.67 | Efficacy of maintenance of therapeutic serum concentrations of theophylline in chronic asthma. ( Barrueco, M; Dominguez-Gil, A; Gomez, F; Mariño, E; Otero, MJ, 1987) |
| "For assessing the clinical impact of nonlinearity in theophylline elimination, we examined the incidence of individuals with an apparent Michaelis-Menten kinetics (percent change in plasma concentration exceeding that in dose by at least 50%) among asthmatic children (n = 122) and adults (n = 50) screened through a two-step chart review." | 7.67 | Incidence of apparent Michaelis-Menten kinetic behavior of theophylline and its parameters (Vmax and Km) among asthmatic children and adults. ( Ishizaki, T; Kubo, M, 1987) |
| "The effects of pregnancy on the disposition of theophylline were assessed in 10 patients throughout pregnancy and post-partum." | 7.67 | Longitudinal effects of pregnancy on the pharmacokinetics of theophylline. ( Cousins, L; Gardner, MJ; Jusko, WJ; Middleton, E; Schatz, M; Zeiger, R, 1987) |
| "Intrasubject variability in theophylline pharmacokinetics was assessed in six subjects with mild/moderate asthma." | 7.67 | Intraindividual variability in theophylline pharmacokinetics in subjects with mild/moderate asthma. ( Adams, E; Choi, L; Goldberg, A; Middleton, E; Slaughter, RL, 1987) |
| "The concentrations of theophylline, terbutaline and salbutamol in post-mortem blood samples from 68 patients (17-85 years old) with asthma or chronic obstructive lung disease, 54 of whom had died of asthma, were analysed." | 7.67 | Post-mortem concentrations of salbutamol, terbutaline and theophylline in asthma patients. ( Boman, G; Lindsjö, M; Lindström, B; Strandberg, K; Wiholm, BE, 1987) |
| "Intraindividual changes in theophylline clearance were examined in 13 children with acute exacerbation of asthma receiving a 72-hour constant intravenous infusion of aminophylline." | 7.67 | Intraindividual changes in theophylline clearance during constant aminophylline infusion in children with acute asthma. ( Ishizaki, T; Kanagawa, S; Kubo, M; Nagai, T; Odajima, Y; Yamaguchi, M, 1986) |
| "To test the hypothesis that nighttime and early morning signs and symptoms of air flow obstruction in patients with moderately severe asthma would be better controlled by theophylline given on a once-a-day evening dosing schedule chosen to provide a peak blood level in the early morning than by the traditional twice-a-day dosing schedule designed to maintain levels more constant throughout the 24-hour period, the effects on nocturnal asthma of Uniphyl once a day and Theo-Dur twice a day were studied in 14 patients with moderately severe asthma." | 7.67 | Timing of once-a-day theophylline dose to match peak blood level with diurnal variation in severity of asthma. ( Conrad, E; Reed, CE; Welsh, PW, 1986) |
| "To assess the utility of a dose-titration scheme for determining maintenance theophylline requirements, dose requirements and stability of serum concentrations were examined using 3537 serum determinations from 1073 patients with chronic asthma during a 5-year period." | 7.67 | Evaluation of a scheme for establishing and maintaining dosage of theophylline in ambulatory patients with chronic asthma. ( Hendeles, L; Milavetz, G; Vaughan, LM; Weinberger, MM, 1986) |
| "The incidence of preeclampsia was reduced among asthmatic patients taking theophylline (one of 85) compared to other asthmatic patients (six of 68, p less than 0." | 7.67 | Incidence of preeclampsia among asthmatic patients lower with theophylline. ( Boike, GM; Bottoms, SF; Dombrowski, MP; Wald, J, 1986) |
| "Theophylline pharmacokinetics were studied serially in five women during and after pregnancy." | 7.67 | Theophylline pharmacokinetics in pregnancy. ( Atkinson, AJ; Chow, MJ; Frederiksen, MC; Ruo, TI, 1986) |
| "Fifteen asthmatic patients receiving a sustained-release theophylline preparation were also treated with spiramycin for at least 5 days." | 7.67 | Spiramycin has no effect on serum theophylline in asthmatic patients. ( Bigot, MC; Debruyne, D; Jehan, A; Lechevalier, B; Moulin, M; Prevost, JN, 1986) |
| "Theophylline clearance was prospectively studied in eight pregnant asthmatic patients who were receiving maintenance doses of theophylline." | 7.67 | Theophylline clearance during pregnancy. ( Carter, BL; Driscoll, CE; Smith, GD, 1986) |
| "Forced expiratory volume in the first second (FEV1) and serum theophylline levels were measured comparatively in 26 patients with stable bronchial asthma after a 240 mg theophylline infusion." | 7.67 | [Serum levels and bronchodilatation after intravenous administration of theophylline in asthmatic patients]. ( Andrejak, M; Aubry, P; Lary, H; Levi-Valensi, P, 1986) |
| "Two patients are presented who required higher than usual doses of theophylline to control their asthma." | 7.67 | High theophylline doses required for asthma control. ( Jones, LM, 1986) |
| "A method for converting pediatric patients from intravenous aminophylline to sustained-release oral theophylline was evaluated in eight asthmatic children." | 7.67 | Conversion from intravenous to sustained-release oral theophylline in pediatric patients with asthma. ( Clarke, DF; Grodin, MA; Shargel, L; Werbowsky, OL, 1986) |
| "The influence of age on the disposition of theophylline was studied in 95 adult patients (nonsmokers) with bronchial asthma requiring oral theophylline therapy: 17 patients age less than or equal to 39 years, 50 patients age 40-59 years, and 28 patients greater than or equal to 60 years." | 7.67 | Individualization of theophylline dosage in adults with bronchial asthma. ( Barrueco, M; Dominguez-Gil, A; Gomez, F; Mariño, EL; Otero, MJ, 1986) |
| "Plasma and saliva theophylline concentrations were measured in 21 asthmatic subjects receiving chronic oral therapy with a new sustained-release theophylline capsule (K1B Riker) given as a once daily dose, after titration to achieve a before-dose concentration of 8 mg l-1 or greater, or to the maximum dose of 1200 mg of theophylline daily." | 7.67 | Steady-state pharmacokinetics and effects of a new once-daily, slow-release theophylline capsule preparation in asthma. ( Alwazir, YA; Campbell, IA; Routledge, PA; Williams, PE, 1986) |
| " In order to evaluate the relative contribution of vagal and non-vagal afferences to increasing neural drive to the respiratory muscles in 14 asymptomatic asthmatic patients known to be responsive (decrease in FEV1 greater than 20% of the control values) to previous bronchial provocation test (BPT) with aerosolized histamine, we evaluated FEV1, breathing pattern and neuromuscular drive, as assessed by mouth occlusion pressure (PO." | 7.67 | Effects of histamine and reproterol inhalation on mouth occlusion pressure in patients with bronchial asthma. ( Arcangeli, P; Duranti, R; Emmi, L; Gigliotti, F; Lo Conte, C; Scano, G; Spinelli, A; Stendardi, L; Turco, R, 1986) |
| "Sustained-release theophylline compounds given once (Uniphyl) or twice (Theodur) daily were compared in adult asthmatics." | 7.67 | Comparison of once-a-day and twice-a-day theophylline in asthma. ( Fairshter, RD; Lowe, JE; Novey, HS; Salness, K; Wilson, AF, 1986) |
| "To determine the usefulness of clinical information in predicting theophylline levels, 21 parameters were studied in 204 asthmatic patients." | 7.67 | Clinical predictors of theophylline blood levels in asthmatic patients. ( Marcus, RH; Parvin, CA; Stine, RJ, 1987) |
| "The authors report the results obtained with one single daily dose of 10 mg/kg of a long-acting theophylline preparation administered in the evening to asthmatic patients previously treated with the same dose twice a day." | 7.67 | [Value of a daily dose of theophylline in the treatment of nocturnal asthma]. ( Godard, P; Kleisbauer, JP; Mazoyer, F; Muir, JF; Paramelle, B, 1986) |
| "A group of 167 pediatric asthmatics were followed up over four years, and their theophylline clearance values were recorded when they were admitted for status asthmaticus." | 7.67 | The use of theophylline clearance in pediatric status asthmaticus. I. Interpatient and intrapatient theophylline clearance variability. ( Anolik, R; Kolski, GB; Levy, J, 1987) |
| "In 78 children (4 to 17 years of age) with moderate or severe asthma who were additionally treated with sustained-release theophylline preparations, different ways of drug monitoring were examined." | 7.67 | [Monitoring long-term therapy with theophylline preparations in children with asthma]. ( Bauer, J; Lindemann, H; Schwandt, HJ, 1985) |
| "Cromolyn sodium has matured as a first-line drug in the management of asthma in the United States." | 7.67 | Cromolyn sodium in the treatment of asthma: coming of age in the United States. ( Bernstein, IL, 1985) |
| "A sustained-release theophylline preparation (Theo-Dur Sprinkle) was evaluated in young asthmatic patients aged 1 to 6 years and receiving a daily dose of 23." | 7.67 | Evaluation of serum theophylline concentrations following administration of sustained-release beads in applesauce to asthmatic preschool children. ( Correia, J; Isles, AF; Leeder, JS; Levison, H; Macleod, SM; Robertson, C, 1986) |
| "We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer." | 7.67 | Perforated gastric ulcer in an asthmatic treated with theophylline and steroids. Case report and literature review. ( Chiaramonte, LT; Guss, C; Schneider, AT, 1986) |
| "Thirty-nine chronic asthmatic children were enrolled in a 6-month outpatient theophylline compliance study." | 7.67 | Theophylline compliance in asthmatic children. ( Cuskey, W; Weinstein, AG, 1985) |
| "During routine monitoring of hospitalized children with asthma receiving a sustained-release theophylline formulation, we frequently observe unpredictable fluctuations in serum theophylline concentration (STC)." | 7.67 | Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children. ( Kalisker, A; Rogers, RJ; Szefler, SJ; Wiener, MB, 1985) |
| "The case is presented of a 39-year-old male in status asthmaticus who failed to respond to conventional therapy, including positive pressure ventilation, and who required halothane anesthesia." | 7.67 | The use of halothane in the treatment of status asthmaticus. ( Bayliff, CD; Faclier, G; Koch, JP, 1985) |
| "After literature reports linking fibrocystic breast disease (FBD) to methylxanthine ingestion, a pilot study was undertaken to investigate the possible contribution of theophylline to this effect." | 7.67 | Theophylline and fibrocystic breast disease. ( Bullough, B; Hindi-Alexander, MC; London, WM; Middleton, E; Montes, N; Rosner, DH; Zielezny, MA, 1985) |
| "The disposition of theophylline was examined in seven children with asthma on two occasions before and on one occasion after chronic phenobarbital dosing (2 mg/kg/day)." | 7.67 | The effect of phenobarbital on theophylline disposition in children with asthma. ( Danish, M; Greene, J; Mansmann, HC; Ragni, MC; Rocci, ML; Saccar, CL; Yaffe, SJ, 1985) |
| "The lung function profiles of a group of six healthy volunteers and six patients with moderately severe asthmatic bronchitis were compared after one theophylline infusion and after oral administration of Theograd (350 mg), Theolair Retard (350 mg), and Theolin Retard (300 mg) all given twice daily for 1 week." | 7.67 | Pharmacokinetics and pharmacodynamics of three sustained-release theophylline preparations (Theograd, 350 mg Theolair Retard, and 300 mg Theolin Retard) in steady state in six normals and six patients with chronic asthmatic bronchitis--Part II: Lung funct ( Drost, RH; Kreukniet, J; Maes, RA; van der Vet, AP, 1985) |
| "Fifty two preschool children with asthma were given a recommended regimen of slow release theophylline." | 7.67 | Treatment of asthma in preschool children with slow release theophylline. ( Loftus, BG; Price, JF, 1985) |
| "A sustained-release theophylline (SRT) tablet was evaluated in 15 children with moderately severe asthma between the ages of 3 and 5 years (4." | 7.67 | Evaluation of a sustained-release theophylline tablet in young asthmatics. ( Baldwin, JN; Kobayashi, RH; Swigart, SA, 1985) |
| "Several theophylline pharmacologic strategies were tested for the forgetful medication-dependent asthmatic who frequently initiates treatment from below the therapeutic range of 10 to 20 micrograms/mL." | 7.67 | Sustained release theophylline for the forgetful asthmatic. ( Weinstein, AG, 1985) |
| "The trough steady-state concentration of theophylline in plasma and stimulated saliva of 12 asthmatic children receiving an oral slow-release theophylline preparation was determined after 1 week of treatment." | 7.67 | Relationship between plasma and stimulated-saliva concentrations of theophylline in asthmatic children. ( Hoffer, E; Krivoy, N; Rubin, A; Teitelman, U; Zinman, P, 1985) |
| "We studied 16 adults with chronic bronchial asthma by measuring the plasma theophylline concentrations and evaluating clinically the control of asthma following oral administration of choline theophyllinate (CT) and a sustained-release theophylline preparation (SRT)." | 7.67 | A comparative study of the use of choline theophyllinate and a sustained-release theophylline in adults with chronic asthma. ( Chan, KW; Feng, PH; Lee, HS; Tan, TH; Ti, TY, 1985) |
| "The effects of histamine, antihistamines, isoproterenol and theophylline on the expressions of Fc and complement (C') receptors on the polymorphonuclear leukocytes (PMN's) were studied in 40 asthmatic children." | 7.66 | The effects of histamine, antihistamines, isoproterenol and theophylline on the Fc and complement receptor functions of polymorphonuclear leukocytes in asthmatic children. ( Hsieh, KH, 1981) |
| "In 9 "stable" adult asthmatics, the relationship between serum theophylline level and pulmonary function, as well as the interaction of aminophylline and inhaled beta2-agonist on pulmonary function, were studied." | 7.66 | Relationship between serum theophylline levels and pulmonary function before and after inhaled beta-agonist in "stable" asthmatics. ( Cherniack, RM; Klein, JJ; Lefkowitz, MS; Spector, SL, 1983) |
| "Two groups of asthmatic children were found with regard to the influence of theophylline on the anti-IgE-induced histamine release from whole blood." | 7.66 | In vitro influence of theophylline on anti-IgE-induced release from leucocytes and whole blood in asthmatic children. ( Burtin, C; Fermanian, J; Lebel, B; Paupe, H; Scheinmann, P, 1981) |
| "Studies using the guinea pig ileum bioassay technique have previously shown that patients with either asthma or chronic bronchitis have increased amounts of histamine in their sputum." | 7.66 | Histamine content of sputum from patients with asthma and chronic bronchitis. ( Bryant, DH; Pui, A, 1982) |
| "Authors have studied pharmacokinetic parameters of theophylline in a sample of 21 children with bronchial asthma, through evolution of plasmatic concentrations, evaluated by RIA, in order to appreciate therapeutic response to it depending on the time-variation of such concentrations." | 7.66 | [Pharmacokinetics of theophylline in infantile bronchial asthma. Clinical findings]. ( Girón, F; Loscertales, M; Martínez Sampere, JJ; Olea, N; Pedraza, V; Puentes, C; Ruiz Estremera, A, 1982) |
| "The absolute T-cell numbers and function, and the T-suppressor-cell subset were tested in eleven children with extrinsic asthma prior to and 1 month after theophylline treatment." | 7.66 | Induction of suppressor T cells in asthmatic children by theophylline treatment. ( Shohat, B; Varsano, I; Volovitz, B, 1983) |
| "Beta-adrenergic refractoriness was assessed in human lymphocytes following in vivo administration of the beta-adrenergic agonist, metaproterenol, the phosphodiesterase inhibitor, theophylline, or both concomitantly, to normal and asthmatic subjects." | 7.66 | Lymphocyte beta-adrenergic refractoriness induced by theophylline or metaproterenol in healthy and asthmatic subjects. ( Abrass, IB; Littner, MR; Scarpace, PJ; Tashkin, DP, 1982) |
| "Twenty children aged between 5 and 16 suffering from severe asthma were treated with long acting oral theophylline." | 7.66 | [Sustained-action oral theophylline in the asthmatic child. Clinical, pharmacokinetic and respiratory function studies]. ( Baculard, A; Boule, M; Gaultier, C; Morgant, G; Tournier, G, 1983) |
| "Ninety-three patients presenting with acute asthma to the emergency department were studied to determine theophylline levels and their relationship to airway obstruction, history of prior medication use, and side effects of treatment." | 7.66 | Theophylline concentrations in the emergency treatment of acute bronchial asthma. ( Anderson, JA; Emerman, CL; Nowak, RM; Sarkar, D; Tomlanovich, MC; Yanari, S, 1983) |
| "The absolute oral bioavailability of a sustained release theophylline tablet (Nuelin-SR250), given 12 hourly was determined in 14 asthmatic children aged 5 to 13 years." | 7.66 | Bioavailability and diurnal variation in absorption of sustained release theophylline in asthmatic children. ( Birkett, DJ; Coulthard, KP; Grgurinovich, N; Grygiel, JJ; Lines, DR, 1983) |
| "Analyses of 90 admissions to the Cincinnati Children's Hospital Center, Cincinnati, Ohio, were used to assess the effects of the routine availability of serum theophylline determinations (STD) in treating acute in-hospital asthma over three one-year review periods coinciding with the relative availability of STD." | 7.66 | Use of serum theophylline determinations during acute asthma therapy in children. ( Fischer, TJ; Hunter, RH; Kearns, GL, 1982) |
| "In a 12-week study 20 children, ages two to seven years, with moderate to severe asthma received 20 mg cromolyn sodium via a power-driven nebulizer four times daily." | 7.66 | Safety, efficacy and bronchodilator-sparing effects of nebulized cromolyn sodium solution in the treatment of asthma in children. ( Prenner, BM, 1982) |
| "Eleven children suffering from an acute asthma attack were treated with 6 mg theophylline/kg given as a single dose of a new theophylline liquid (Nuelin Liquid, Riker) (day 1)." | 7.66 | Pharmacokinetics of a new theophylline liquid in asthmatic children. ( Pedersen, S, 1983) |
| "This study was performed to assess the need of obtaining serum theophylline (T) levels between 10--20 micrograms/ml to achieve maximum reversibility of airway obstruction in chronic childhood asthma." | 7.66 | Theophylline administration in children with asthma: optimal pulmonary function and possible tolerance to chronic administration. ( Katz, RM; Mickey, R; Rachelefsky, GS; Siegel, SC, 1983) |
| "To facilitate administration of sustained-release theophylline in pediatric patients fourteen children with asthma were studied using intact capsules versus the granular contents in apple sauce." | 7.66 | Bioavailability of sustained-release theophylline granules in apple sauce in pediatric asthmatic patients. ( Carroll, S; Lotner, GZ; Spangler, DL; Tinkelman, DG; Vanderpool, GE, 1983) |
| "In order to determine the types of respiratory responses observed during aspirin-induced reactions, 50 consecutive asthmatic patients with a history of aspirin sensitivity underwent prospective oral aspirin challenges between 1979 and 1981." | 7.66 | Aspirin-sensitive rhinosinusitis/asthma: spectrum of adverse reactions to aspirin. ( Mathison, DA; Pleskow, WW; Schatz, M; Simon, RA; Stevenson, DD; Zeiger, RS, 1983) |
| "Continuous sustained-release theophylline therapy was used in 61 children with severe asthma, aged 5 to 16 years." | 7.66 | [Continuous treatment of asthma in children with theophylline retard]. ( Benoist, MR; de Blic, J; Paupe, J; Ruff, F; Scheinmann, P, 1983) |
| "Plasma concentration and pharmacokinetic data of a sustained-release theophylline (Theolair retard) was compared with that of a short-acting theophylline (Theolair) in six normals and six patients with asthmatic bronchitis." | 7.66 | Pharmacokinetics and pharmacodynamics of a short- and long-acting theophylline medication (theolair and Theolair retard) in normals and asthmatics. Part I: pharmacokinetics. ( Kreukniet, J; Maes, RA; Meering, PG; Utama, I, 1983) |
| "Serial serum theophylline levels were measured in 20 inpatient asthmatics given tablets of either microcrystalline or sustained-release theophylline." | 7.66 | Serum theophylline levels in adult asthmatics: comparison of oral sustained-release and microcrystalline preparations. ( Jones, DT; Sears, MR, 1980) |
| "Dihydroxypropyl theophylline (dyphylline) was administered by aerosol in a single dose of 250 mg aerosolized over five minutes to two asthmatic volunteers and in a single dose of 375 mg aerosolized over ten minutes to two other asthmatic volunteers." | 7.66 | Dyphylline aerosol can induce bronchospasm in human asthmatics. ( Auer, S; Bardana, E; Brottem, J; Downes, H; Hirshman, C; Lawyer, C; Lynn, R, 1982) |
| "The newborn's potential for xanthine toxic reactions from placental transfer of theophylline or caffeine conversion from theophylline was studied in 12 newborns of asthmatic mothers." | 7.66 | Placental theophylline transfer in pregnant asthmatics. ( Labovitz, E; Spector, S, 1982) |
| "The kinetics and the effects on the ventilatory function peak expiratory flow rate (PEFR) of a single 600-mg oral dose of theophylline were investigated in 46 adult patients with bronchial asthma (BA) and in 16 adult patients with chronic airflow obstruction (CAO)." | 7.66 | Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: influence of erythromycin. ( Bah, H; Duroux, P; Giudicelli, JF; Mathieu, M; Richer, C; Thuillez, C, 1982) |
| "Theo-Dur, a sustained-release theophylline formulation, was administered every 12 hours for three months to ten asthmatic children aged 3 to 7 years, with no evidence of adverse reaction or tolerance." | 7.66 | Sustained-release theophylline for treatment of asthma in preschool children. ( Luciuk, GH; Simons, FE; Simons, KJ, 1982) |
| "The bronchodilating properties and side effects of theophylline and a beta 2-adrenoceptor stimulating drug (terbutaline) alone and in combination were studied in 10 adult asthmatic patients." | 7.66 | Separate and combined use of terbutaline and theophylline in asthmatics. Effects related to plasma levels. ( Billing, B; Dahlqvist, R; Garle, M; Hörnblad, Y; Ripe, E, 1982) |
| "Theophylline reduces asthmatic bronchial obstruction; this desired therapeutic action but also the occurrence of unpleasant and dangerous side effects depends directly on its tissue and serum concentration." | 7.66 | [Theophylline in the treatment of childhood asthma]. ( Zach, M, 1982) |
| "Intravenous maintenance aminophylline infusion rate can be calculated from the previously received equivalent oral dosage in children with chronic asthma with considerable accuracy." | 7.66 | Intravenous maintenance aminophylline dosage in patients with asthma on regular oral theophylline. ( Bell, TD; Chai, H; Chang, KC; Miles-Lawrence, R; Pinney, CT, 1982) |
| "The authors followed up the plasma theophylline level in 51 patients with bronchial asthma treated with novphyllin." | 7.66 | [Plasma theophylline level in patients with bronchial asthma treated with novphyllin]. ( Dimitrov, V; Kosturkov, G; Mileva, Zh; Slavov, S; Vasileva, S, 1982) |
| "Serum levels of theophylline were determined in 54 asthmatics children aged 3,92 +/- 2,45 years, who were taken oral theophylline at doses of 4,99 +/- 0,45 mg." | 7.66 | [Serum theophylline levels after oral administration in a group of asthmatic children]. ( Borges Domingo, T; de la Morena, E; Escorihuela, R; Lillo Lillo, M; Llerena, P; López-Linares, M; Royo, F, 1982) |
| "This study compared the bronchodilator effect in experimental canine asthma of dyphylline administered by aerosol and intravenous routes in doses producing equivalent concentrations of the drug in the plasma." | 7.66 | Dyphylline aerosol attenuates antigen-induced bronchoconstriction in experimental canine asthma. ( Downes, H; Farbood, A; Gerber, N; Hirshman, CA; Lawyer, C; Rodgers, R, 1981) |
| "A patient developed severe asthma following insulation of her house with urea-formaldehyde foam." | 7.66 | Asthma induced by dust from urea-formaldehyde foam insulating material. ( Filley, WV; Frigas, E; Reed, CE, 1981) |
| "Authors have adjusted oral theophylline requirements in 55 asthmatic children, whose ages ranged from 19 months to 14 years, following a preconceived plan." | 7.66 | [Individualization of the dosage of oral theophylline with regular increase method and serum level control in 55 asthmatic children (author's transl)]. ( Cabanas, R; Castro-Gago, M; Cortizo, E; Fuster, M; Peña, J; Tojo, R; Vázquez, MC, 1981) |
| "The pharmacokinetics of theophylline following a single intravenous dose of aminophylline were determined in 8 asthmatic patients in each of the acute, the recovery and the remission phase." | 7.66 | A comparison of the pharmacokinetics of theophylline in asthmatic children in the acute episode and in remission. ( Arnold, JD; Hill, GN; Sansom, LN, 1981) |
| " A comparative study with various drug used in the treatment of asthma (isoprenaline, metaproterenol, salbutamol, clenbuterol, papaverine and atropine) has been conducted." | 7.66 | Reproterol and the muscle of the trachea and bronchi: in vitro and in vivo comparative studies with various drugs used in the treatment of asthma. ( Di Mezza, F; Giordano, L; Marmo, E; Montanaro, A; Scognamiglio, M, 1981) |
| "During both the 1977 and 1978 eight-week summer sessions at Bronco Junction the effect of oral inhalation of beclomethasone dipropionate and optimum dose theophylline therapy in 56 chronically severe, corticosteroid dependent asthmatic children was evaluated." | 7.66 | Use of inhaled beclomethasone dipropionate and optimized theophylline doses in asthmatic children at Camp Bronco Junction, 1977-1978. ( Morton, JL; Scherr, LB; Scherr, MS, 1980) |
| " It has been known to have side effects such as dyskinesia, but this case details the emergence of dystonia and dyskinesia when the simultaneous use of methylphenidate and a phenothiazine was followed by withdrawal of the phenothiazine." | 7.66 | Methylphenidate, neuroleptics and dyskinesia-dystonia. ( Chapel, J; Husain, A; Malek-Ahmadi, P, 1980) |
| "Theophylline preparations have long been the mainstay in the management of asthma." | 7.66 | Intravenous theophylline therapy in asthma: a clinical update. ( Rothstein, RJ, 1980) |
| "The purpose of this study was to determine whether a new sustained-release theophylline preparation TheoDur could maintain therapeutic serum theophylline levels in asthmatic children on a 12-hour dosage regimen." | 7.66 | Efficacy of a 12-hour sustained-release preparation in maintaining therapeutic serum theophylline levels in asthmatic children. ( Kelly, HW; Murphy, S, 1980) |
| " The present program for a hand-held calculator (TI-59) was written to minimize these problems, and was designed for the use of intravenous theophylline in the management of acute asthma, where there is a need for individualisation of dosage." | 7.66 | A hand-held calculator program for individualized dosage adjustment of intravenous theophylline in acute asthma. ( Madsen, BW; Paterson, JW; Tarala, RA, 1980) |
| "Serum theophylline concentrations were measured in 17 children and adolescents with acute asthma who received an aminophylline loading dose of 7 mg/kg and a constant infusion of 15 mg/kg/24 hours." | 7.66 | Pharmacokinetics of theophylline in acute asthma. ( Bierman, CW; Pierson, WE; Shapiro, GG; Simons, FE; Simons, KJ, 1978) |
| "Possible interaction of erythromycin with theophylline is a problem in the dental treatment of asthmatic patients." | 7.66 | The interaction of erythromycin and theophylline in the asthmatic dental patient. ( Hendeles, L; Walker, J, 1979) |
| "Theophylline has become useful not just as an acute bronchodilator, but also as a major prophylactic agent for the suppression of symptoms of chronic asthma." | 7.66 | Theophylline for treatment of asthma. ( Weinberger, M, 1978) |
| "The quantitative effects of theophylline anhydrous upon exercise-induced asthma (EIA) were evaluated in asthmatic children." | 7.66 | Quantitative effect of theophylline anhydrous on exercise-induced asthma after maximal physical effort. ( Bruns, WT; Chryssanthopoulos, C; Gallen, WJ; Hause, LL; Maksud, MG, 1979) |
| "Sub-therapeutic theophylline levels due to patient (parent) non-compliance is a significant cause of outpatient treatment failure in childhood asthma." | 7.66 | Non-compliance in asthmatic children: a study of theophylline levels in a pediatric emergency room population. ( Kadlec, GJ; Karibo, JM; Pollard, SJ; Sublett, JL, 1979) |
| "Twenty children, five to 16 years old, diagnosed as having asthma, were studied to compare the serum concentrations of theophylline obtained by standard venipuncture with capillary concentrations obtained by finger lancet." | 7.66 | Comparison of theophylline concentrations in venous blood and capillary blood in asthmatic children. ( Rosen, JP; Umstead, GS, 1979) |
| "Serum theophylline levels produced in asthmatic children by sustained-release theophylline tablets (TheoDur) were studied." | 7.66 | Serum theophylline levels in asthmatic children receiving sustained-release theophylline tablets. ( Kelly, HW; Murphy, S, 1979) |
| "A study was carried out in 25 patients with asthma caused by exposure to occupational antigens to investigate the effectiveness of reproterol in protecting and terminating the bronchoconstrictor response to inhaled antigens." | 7.66 | Inhibition of artifically-induced asthma by reproterol ('Bronchospasmin'). ( Bianco, S; Kamburoff, PL; Prime, FJ, 1979) |
| "Twenty-one adult chronic asthmatic patients were studied while taking a 12-hour sustained-action theophylline tablet." | 7.66 | Use of a twelve-hour theophylline preparation in chronic adult asthmatics. ( Carroll, MS; Spangler, DL; Tinkelman, D; Vanderpool, G, 1979) |
| "Theophylline dosage requirements to maintain serum concentrations of 10 to 20 microgram/ml among asthmatic patients were examined in 156 children, ages 2 1/2 months to 16 years, and 33 otherwise health adults." | 7.66 | Oral theophylline dosage for the management of chronic asthma. ( Hendeles, L; Weinberger, M; Wyatt, R, 1978) |
| "Efficacy and dose-response activity of oral theophylline were evaluated in 21 asthmatic children, using inhibition of exercise-induced bronchospasm (EIB) as a therapeutic marker." | 7.66 | Exercise, induced bronchospasm in asthmatic children as a dose-response model for theophylline. ( Bierman, CW; Cho, YW; Pierson, WE; Shapiro, GG, 1978) |
| "Theophylline, when used appropriately, seems to be the most effective noncorticosteroid prophylactic medication for chronic asthma." | 7.66 | Guide to oral theophylline therapy for the treatment of chronic asthma. ( Hendeles, L; Weinberger, M; Wyatt, R, 1978) |
| "Theophylline disposition (clearance, volume of distribution, and half-life) was measured in 31 normal volunteers and 26 acutely ill patients with airway obstruction within 24 hours of hospital admission and again when intravenous aminophylline was discontinued 2 to 10 days later." | 7.66 | Theophylline disposition in acutely ill hospitalized patients. The effect of smoking, heart failure, severe airway obstruction, and pneumonia. ( Costello, J; Hopewell, P; Powell, JR; Riegelman, S; Sheiner, LB; Vozeh, S, 1978) |
| "The efficacy of continuous, around-the-clock sustained-release (S-R) theophylline therapy, adjusted to approximate serum or plasma steady state theophylline concentrations (Tc) of 15 microgram/ml three hours following the last dose, was assessed in 18 children suffering from moderately severe chronic asthma." | 7.66 | Sustained-release theophylline therapy for chronic childhood asthma. ( Bell, T; Bigley, J, 1978) |
| "Serum theophylline concentrations measured in 25 asthmatic children for whom continual therapy had been prescribed were found to exceed 8 mcg/ml more often in those receiving sustained-release theophylline preparations than those receiving short-acting theophylline preparations." | 7.66 | Serum theophylline concentrations in asthmatic children. ( Sheen, A; Sly, RM, 1978) |
| "Serum theophylline levels were measured throughout the day in 65 asthmatic children receiving one of two slow-release theophylline compounds." | 7.66 | Serum theophylline levels in asthmatic children after oral administration of two slow-release theophylline preparations. ( Baillie, E; McKenzie, S, 1978) |
| "Ten patients with exercise-induced asthma were premedicated with oral salbutamol and oral theophylline on separate occasions before performing a standardised exercise test." | 7.65 | A comparison of oral theophylline and oral salbutamol in exercise-induced asthma. ( Anderson, SD; Lindsay, DA; Seale, JP, 1977) |
| "To test the efficacy of using a weight-derived formula to determine aminophylline dosages, 50 patients hospitalized for treatment of severe asthma were given intravenous aminophylline infusions at a rate of 0." | 7.65 | Theophylline concentrations in asthmatic patients after administration of aminophylline. ( Kordash, TR; McCall, JT; Van Dellen, RG, 1977) |
| "This study examined the effectiveness of theophylline therapy in modifying exercise-induced bronchospasm (EIB) in children with perennial asthma and evaluated whether tolerance to theophylline developed with prolonged use." | 7.65 | Acute and chronic theophylline therapy in exercise-induced bronchospasm. ( Bierman, CW; Dorsett, CS; Pierson, WE; Shapiro, GG, 1977) |
| "Theophylline clearance was examined in 23 children with chronic asthma by administering constant intravenous infusions of theophylline until steady-state serum concentrations were documented." | 7.65 | Relationship of theophylline clearance to oral dosage in children with chronic asthma. ( Ginchansky, E; Weinberger, M, 1977) |
| "Prior assumptions of first-order elimination for theophylline were tested by administering theophylline by intravenous infusion at two dosage levels to 20 children with chronic asthma." | 7.65 | Dose-dependent kinetics of theophylline disposition in asthmatic children. ( Ginchansky, E; Weinberger, M, 1977) |
| "1 Ephedrine plasma levels have been measured in ten asthmatic patients given a singel dose of ephedrine hydrochloride (22 mg) along and in combination with theophylline and a barbiturate." | 7.65 | The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment. ( May, CS; Paterson, JW; Pickup, ME; Ssendagire, R, 1976) |
| "Previously published data of plasma concentrations and pharmacologic effects obtained after rapid intravenous injection and during constant rate intravenous infusion of theophylline in asthmatic children were analyzed pharmacokinetically to determine the relationship between effect on pulmonary function (improvement of forced expiratory volume in the first second) and drug level." | 7.65 | Pharmacokinetic analysis of the effect of theophylline on pulmonary function in asthmatic children. ( Koysooko, R; Levy, G, 1975) |
| "In eight asthmatic patients, there was no change in the bronchodilator response to a single dose of ephedrine (22 mg) given alone or in a compound tablet, after treatment with ephedrine (11 mg three times a day) or one tablet three times a day for 2 weeks." | 7.65 | The acute and chronic bronchodilator effects of ephedrine in asthmatic patients. ( May, CS; Paterson, JW; Pickup, ME, 1975) |
| "A group of ambulatory asthmatic children was studied with serum and salivary theophylline levels following a prescribed dose of a hydroalcoholic solution of theophylline to determine compliance." | 7.65 | Compliance of chronic asthmatics with oral administration of theophylline as measured by serum and salivary levels. ( Eney, RD; Goldstein, EO, 1976) |
| " This study was performed to compare the efficacy of inhaled corticosteroids (ICS) combined with slow-release theophylline (SRT) with that of double-dose ICS in asthma control, anti-inflammatory activity and safety." | 6.71 | Comparison of inhaled corticosteroid combined with theophylline and double-dose inhaled corticosteroid in moderate to severe asthma. ( Li, SP; Liao, XQ; Lin, KX; Qian, GS; Song, YX; Wang, CZ; Wang, Y; Zhao, ZQ; Zhuo, WL, 2005) |
| "Bronchial asthma is eosinophilic airway inflammation with enhanced airway responsiveness induced by eosinophilic granule proteins such as eosinophilic cationic protein (ECP) that are released from eosinophils." | 6.70 | [Effects of once-daily low-dose administration of sustained-release theophylline on airway inflammation and airway hyperresponsiveness in patients with asthma]. ( Terao, I, 2002) |
| " Following individual dosing of 100-300 mg theophylline twice a day, a pharmacokinetic profile for 24 h was derived after seven days of multiple dosing." | 6.69 | [Pharmacokinetics of theophylline in sustained-release formulation in young asthmatics]. ( Fuchs, WS; Heese, U; Laicher, A; von Nieciecki, A; Witschital, K, 1998) |
| "Histamine challenges were carried out by tidal breathing method at entry, and at Days 4, 8, 22, 36, and 40." | 6.69 | Effects of theophylline on tolerance to the bronchoprotective actions of salmeterol in asthmatics in vivo. ( Cheung, D; de GOEIJ, JA; de GRAAFF, CS; Steen, H; Sterk, PJ; Wever, AM, 1998) |
| " The pharmacokinetic characteristics of Xanthium were compared with those of Theo-Dur in twelve Thai children with stable persistent asthma by randomized, double blind, crossover study." | 6.69 | Comparative study of the pharmacokinetic characteristics of slow release theophylline oral preparations in Thai children with persistent asthma. ( Jiraporncharoen, K; Kanthawatana, S; Tontayapiwat, A; Trakultivakorn, M, 1999) |
| " In Ex I and II, no subjects had adverse effects and in Ex I no influence on ECG was seen." | 6.69 | Usefulness and safety of theophylline injection form (Theodrip) for the treatment of acute asthma. ( Fukui, H; Katoh, H; Kawai, H; Kojima, J; Ohnishi, A; Onodera, K; Taniguchi, T, 2000) |
| "To investigate the effect of small dose of oral theophyllin combined with low dose of inhaled beclomethasone dipropionate (BDP) on clinical symptoms, bronchial responsiveness and hypothalamic-pituitary-adrenal axis (HPAA)." | 6.69 | [Effect of low dose of inhaled corticosteroid combined with small dose of oral theophylline on treatment of bronchial asthma]. ( Huang, H; Li, J; Mo, H, 2000) |
| "Theophylline may produce a paradoxical increase in awareness of asthma in some individuals." | 6.68 | Influence of treatment with beclomethasone, cromoglycate and theophylline on perception of bronchoconstriction in patients with bronchial asthma. ( Higgs, CM; Laszlo, G, 1996) |
| " To determine whether a calibrated dosage of oral slow-release theophylline inhibits asthmatic reactions and the associated increase of airway responsiveness to methacholine induced by TDI, we examined six asthmatic subjects who developed a late or a dual asthmatic reaction after TDI inhalation challenge." | 6.67 | Theophylline inhibits late asthmatic reactions induced by toluene diisocyanate in sensitised subjects. ( Boschetto, P; Ciaccia, A; Crescioli, S; De Marzo, N; Fabbri, LM; Mapp, CE; Plebani, M; Spinazzi, A, 1992) |
| "In order to determine the effects of repeated administration under fed and fasting conditions on the bioavailability and clinical efficacy of Uniphyl tablets, 22 adult asthmatics took the drug immediately following their evening meal for seven consecutive days and under fasting conditions for an additional seven consecutive days." | 6.67 | Repeated dosing of Uniphyl tablets under fed and fasting conditions: comparison of serum theophylline levels, pulmonary function, and asthma symptoms. ( Arkinstall, WW; Brar, PS; Stewart, JH, 1991) |
| "Theophylline was initially prescribed and monitored in an 'open' phase to obtain the drug dosage required to achieve a serum level in the therapeutic range of 10-20 mg/l." | 6.67 | The effect of sustained-release theophylline in nocturnal asthma. ( Cayton, RM; Freeman, W; Packe, GE, 1991) |
| "treatment." | 6.67 | High-dose inhaled versus intravenous salbutamol combined with theophylline in severe acute asthma. Swedish Society of Chest Medicine. ( , 1990) |
| "Theophylline was titrated for patients to receive, unblinded, theophylline serum concentrations of 10 to 20 micrograms/ml." | 6.67 | Long-term, double-blind comparison of controlled-release albuterol versus sustained-release theophylline in adolescents and adults with asthma. ( Bell, TD; LaForce, CF; MacCosbe, PE; Pierson, WE; Sykes, RS; Tinkelman, D, 1990) |
| " In contrast, the OD treatment was associated with larger peak-to-trough drug level fluctuation, with higher levels produced overnight and lower ones in the evening at the end of the dosing interval." | 6.67 | Twenty-four hour lung function in adult patients with asthma. Chronoptimized theophylline therapy once-daily dosing in the evening versus conventional twice-daily dosing. ( D'Alonzo, GE; Emerson, MB; Feldman, S; Gianotti, LA; Smolensky, MH; Staudinger, H; Steinijans, VW, 1990) |
| " Of the patients who were unable to stop taking theophylline, the Zaditen-and placebo-treated groups recorded average dosage reductions of 62% and 26%, respectively." | 6.66 | A Canadian multicenter study with Zaditen (ketotifen) in the treatment of bronchial asthma in children aged 5 to 17 years. ( Brown, CA; Chandra, RK; Ho, P; Hoogerwerf, PE; Kennedy, RJ; Knight, A; Langer, H; Milne, J; Moote, DW; Rackham, A, 1989) |
| " Two different sustained-release theophylline preparations were used to determine (1) if the serum theophylline concentrations (STC) depend on the type and dosing schedule of the preparation, (2) the relationship between STC and the circadian variations in asthma, and (3) the effect of STC on sleep quality and respiratory patterns during the night." | 6.66 | Circadian variations in theophylline concentrations and the treatment of nocturnal asthma. ( Ballard, RD; Cherniack, RM; Cicutto, LC; Goldenheim, PD; Martin, RJ, 1989) |
| "The pharmacokinetic mechanism of the theophylline-terbutaline interaction has been studied." | 6.66 | Increased theophylline clearance in asthmatic patients due to terbutaline. ( Garty, M; Ilfeld, DN; Mazar, A; Paul-Keslin, L; Rosenfeld, JB; Spitzer, S, 1989) |
| "The relative bioavailability of two slow-release theophylline formulations using bead-filled capsules." | 6.66 | Oral bioavailability of slow-release theophylline from unencapsulated beads in preschool children with chronic asthma. ( Harris, JB; Milavetz, G; Smith, GD; Vaughan, LM; Weinberger, MM, 1988) |
| "Theophylline was stopped 24 hours and other bronchodilators at least 8 hours before the study day." | 6.66 | A dose-response study of the bronchodilator action of azelastine in asthma. ( Bucholtz, GA; Kemp, JP; Meltzer, EO; Middleton, E; Newton, JJ; Orgel, HA; Perhach, JL; Spector, SL; Welch, MJ, 1987) |
| "Eight diurnally active (approximately 0730-1100 hr) adults (41-61 yr) suffering from nocturnal asthma volunteered for a double-blind, cross-over randomized study of a once-daily dosing (600-900 mg/24 hr) of Armophylline (Rorer s." | 6.66 | Comparison of once-daily evening versus morning sustained-release theophylline dosing for nocturnal asthma. ( Abella, ML; Chaouat, D; Gervais, A; Gervais, P; Levi, F; Pauchet, F; Reinberg, A; Ruff, F; Smolensky, MH; Zidani, R, 1987) |
| ") dosage schedules--twice-daily equally divided 12 hr (BID), once-daily evening (OD-PM) and once-daily morning (OD-AM)--were compared under steady-state conditions in 10 adult asthmatics with a documented history of nocturnal dyspnea." | 6.66 | Comparison of sustained-release theophylline scheduled conventionally (twice-daily, equal interval in equal amount) versus once-daily mornings or evenings on circadian pattern of bronchial patency in asthmatics. ( D'Alonzo, GE; Frankoff, HM; Gianotti, L; Hsi, B; McGovern, JP; Smolensky, MH, 1987) |
| " The pharmacokinetics of Theo-24 varied greatly depending on the dosing time." | 6.66 | Administration-time-dependency of the pharmacokinetic behavior and therapeutic effect of a once-a-day theophylline in asthmatic children. ( Baenziger, JC; Harrist, RB; Hiatt, PH; Klank, BJ; Marbella, A; Meltzer, A; Scott, PH; Smolensky, MH; Wong, TK, 1987) |
| "Reproterol is a synthetic selective beta-adrenoceptor agonist with a xanthine side chain." | 6.66 | Bronchial and cardiovascular responses to inhaled reproterol in asthmatics: a double-blind placebo controlled dose-response study. ( Burge, PS; Patchett, P; Patchett, SM, 1985) |
| " single daily dosing with the 24-hour sustained-release theophylline Uniphyl." | 6.66 | Comparison of morning and evening dosing with a 24-hour sustained-release theophylline, Uniphyl, for nocturnal asthma. ( Bush, RK; Busse, WW, 1985) |
| " The same dosage per kilogram for either preparation gave virtually identical mean serum levels suggesting there is no difference in the rate of absorption between the two preparations." | 6.65 | A comparative trial of two slow-release theophylline tablets in the treatment of asthma; Nuelin S.A. and Theocontin Continus tablets. ( Davies, BH; Davies, PD; Hakeem, V; Munn, J, 1984) |
| " Ten asthmatic children who reported a feeling of chest tightness and subsequent wheezing after taking a preparation containing brompheniramine maleate were studied in addition to 10 control asthmatic children who reported no such adverse effect." | 6.65 | Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children. ( Schuller, DE, 1983) |
| " Both dosage forms appeared to have similar kinetic properties within the context of the study." | 6.65 | Bioavailability, efficacy, and tolerance of two sustained-release theophylline dosage forms in adult patients with bronchial asthma. ( Demers, L; Esler, V; Field, E; Trautlein, JJ, 1981) |
| "Theophylline has also been used in the treatment of patients with asthma, although there is a perception that this drug does not offer the patient any advantages over conventional therapeutic strategies." | 6.42 | Theophylline and PDE4 inhibitors in asthma. ( Spina, D, 2003) |
| " Two recently completed trials have demonstrated that with respect to asthma control the combination of inhaled steroid (400 - 800 microg/d) plus theophylline is at least as effective as doubling the dose of inhaled steroid in patients who remain symptomatic on a dosage of 400 - 800 microg daily." | 6.40 | [Asthma therapy: combination of topical glucocorticosteroids and theophylline]. ( Ukena, D, 1997) |
| " Once-daily theophylline when dosed in the evening not only controls nocturnal symptoms and improves airflow during the early morning hours, but decreases airway responsiveness to histamine as well." | 6.38 | Nocturnal asthma: mechanisms and the role of theophylline in treatment. ( Bush, RK, 1991) |
| "Theophylline's role in the treatment of airway obstruction has been challenged, yet it remains a useful agent in the management of obstructive lung disease." | 6.38 | Theophylline in asthma and COPD: changing perspectives and controversies. ( Poe, RH; Utell, MJ, 1991) |
| "Theophylline concentrations in serum between 10 to 20 micrograms/ml cannot be obtained with usual dosage of theophylline in children with individual very short elimination half time of theophylline." | 6.38 | [Individually-adjusted dosages of aminophylline in children with bronchial asthma]. ( Feller, K; Gramatté, T; Leupold, W; Paditz, E; Richter, K, 1990) |
| " Dosing practices that will minimize side effects and toxicity are stressed, along with their management if they do occur." | 6.37 | Theophylline use in asthma. Some current issues. ( Jenne, JW, 1984) |
| " In steady-state we did the pharmacokinetic studies at 1 h, 4 h and 6 h after the administration of one dose." | 6.37 | [Pharmacokinetics of theophylline in children with acute asthmatic crisis]. ( Casasín Edo, T; Closa Monasterolo, R; Gómez Papi, A; Llusa Arbos, M; Tarrés Roure, A, 1988) |
| " Careful dosage titration prevents adverse effects, especially when final dosage is guided by measurement of serum concentration." | 6.36 | Theophylline for chronic asthma: rationale for treatment, product selection, and dosage schedule. ( Hendeles, L; Weinberger, M, 1983) |
| "In the 1990s, numerous double-blind, randomized, placebo-controlled trials revealed that theophylline therapy offered no benefit to inhaled beta2 agonists and systemic corticosteroids in the treatment of patients hospitalized for asthma exacerbations." | 6.20 | Reassessment of theophylline use for severe asthma exacerbation: is it justified in critically ill hospitalized patients? ( Nguyen, WT; Redmond, AM; Self, TH, 2002) |
| "We describe a 25-year-old patient with severe bronchial asthma, which was difficult to treat with oral theophylline." | 6.17 | Severe bronchial asthma improved on bamifylline. Case report and review. ( Bijl, D; Speelberg, B, 1994) |
| "Theophylline and beta 2-mimetic agents have long been used concomitantly in the treatment of asthma, but divergent opinions are lingering on concerning the safety and effectiveness of this combination in both chronic and acute asthma." | 6.16 | [Combination of theophylline and beta-adrenergic agonists in the treatment of asthma: efficacy and tolerance. Review of the literature]. ( Iung, B; Laaban, JP; Rochemaure, J, 1989) |
| "One of the important modes of action of theophylline in asthma and chronic obstructive airway disease may be the inhibition of airway inflammation." | 6.16 | The effects of theophylline on airway inflammation. ( Pauwels, R, 1987) |
| "A total of 58 patients with asthma having chronic cough refractory to ICS/LABA were randomized in a 2:1 ratio to add tiotropium 5 μg (39 patients) or theophylline 400 mg (19 patients) for 4 weeks." | 5.69 | Tiotropium for refractory cough in asthma via cough reflex sensitivity: A randomized, parallel, open-label trial. ( Fukuda, S; Fukumitsu, K; Inoue, Y; Ito, K; Ito, Y; Kanemitsu, Y; Kurokawa, R; Maeno, K; Mori, Y; Niimi, A; Nishiyama, H; Oguri, T; Ohkubo, H; Tajiri, T; Takeda, N; Takemura, M; Uemura, T; Yamamoto, S, 2023) |
| "Terbutaline is used for the management of bronchospasm associated with asthma, bronchitis, emphysema, and chronic obstructive pulmonary disease." | 5.41 | Clinical pharmacokinetics of terbutaline in humans: a systematic review. ( Ashraf, W; Imran, I; Majeed, A; Rasool, MF; Rehman, AU; Saeed, H; Sultan, K; Zamir, A, 2023) |
| "Theophylline is an oral methylxanthine bronchodilator recommended as alternate therapy for the treatment of asthma and chronic obstructive pulmonary disease (COPD)." | 5.41 | Theophylline for the management of respiratory disorders in adults in the 21st century: A scoping review from the American College of Clinical Pharmacy Pulmonary Practice and Research Network. ( Abdalla, M; Bissell, B; Boylan, PM; Malesker, MA; Santibañez, M; Smith, Z, 2023) |
| "Melatonin treatment strengthened contraction responses, but did not affect relaxation responses in rat tracheal preparations." | 5.38 | The achilles heel in melatonin: asthma. ( Belgin Yildirim, F; Karasu-Minareci, E; Kaya, Y, 2012) |
| " Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants." | 5.35 | Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients. ( Igarashi, T; Iwakawa, S, 2009) |
| "The theophylline microcapsules were prepared in four batches, with Eudragit L-100 and S-100 (1:2) by varying drug to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of pulsatile capsule." | 5.34 | Time and pH dependent colon specific, pulsatile delivery of theophylline for nocturnal asthma. ( Dandagi, PM; Gadad, AP; Jain, SS; Kulkarni, AR; Mastiholimath, VS, 2007) |
| "Treatment with theophylline significantly increased FEV1 (3." | 5.31 | [The effect of 6 week treatment with theophylline on spirometric parameters, nonspecific bronchial reactivity and the concentration of soluble interleukin 2 receptor in serum of asthmatic patients]. ( Chazan, R; Droszcz, W; Grubek-Jaworska, H; Mazurek, J; Wrońska, J, 2000) |
| " Then a sustained-release theophylline preparation formulated for once-daily dosing was administered to these patients grouped to examine the effect of the drug on circadian rhythms in PEF." | 5.31 | [Chronotherapy of bronchial asthma: circadian rhythms in peak expiratory flow. The report II: Circadian rhythms of peak expiratory flow in asthmatic patients and effect of sustained-release theophylline on various types of the circadian rhythms]. ( Kagami, M; Nakazawa, T; Tomioka, H; Yoshida, S, 2001) |
| "terbutaline because of bronchoconstriction (dosage not documented)." | 5.30 | [Acute theophylline intoxication as differential diagnosis of pneumothorax in an asthma patient]. ( Schaarschmidt, S; Standl, T, 1997) |
| "Theophylline is an immunomodulator; however, weak effects and the narrow therapeutic window make it a controversial drug." | 5.30 | Differences in the anti-inflammatory effects of theophylline and pentoxifylline: important for the development of asthma therapy? ( Bitter-Suermann, S; Burdon, D; Entzian, P; Ernst, M; Schlaak, M; Zabel, P, 1998) |
| " In the resting state, the chronic administration of theophylline seemed to produce a slight increase in percent fractional shortening, outflow peak velocity and atrial contribution to ventricular filling in the asthmatic children as compared to normals, but these changes were not statistically significant." | 5.29 | Left ventricular function in asthmatic children chronically treated with theophylline evaluated by exercise Doppler echocardiography. ( Aoki, T; Hayashi, H; Iwase, M; Miyaguchi, K; Watanabe, T; Yokota, M, 1994) |
| " We report the case of a 44-year-old woman who presented with toxic effects of theophylline secondary to the use of an over-the-counter product for asthma." | 5.29 | Theophylline toxic effects from an over-the-counter asthma medication. ( Purdom, D; Scarpinato, L, 1993) |
| " For 10 patients this method definitely revealed non-compliance, whereas compliance was doubtful with 12 children and 15 children had strictly adhered to the prescribed dosage regimen." | 5.29 | [Compliance of children with bronchial asthma in long-term therapy with theophylline retard preparations]. ( Köhler, E; Schuster, R; Sollich, V, 1993) |
| " With this dosage the median values of the 24-hour profile (10." | 5.29 | [Inhibition of growth hormone secretion by theophylline in asthmatic children]. ( Baum, WF; Klöditz, E; Schneyer, U, 1996) |
| " Dosage was according to age between 11 and 24 mg/kg body weight and day." | 5.29 | [Comparison of serum concentrations of once and twice daily administration of ultra-retard theophylline in school children with bronchial asthma]. ( Liebke, C; Niggemann, B; Wahn, U, 1996) |
| " However, the pharmacokinetic interaction between mexiletine and theophylline has not been clarified." | 5.28 | [The effect of mexiletine on theophylline pharmacokinetics in patients with bronchial asthma]. ( Hariya, Y; Hayakawa, H; Inafuku, M; Nagasawa, K; Nakahara, Y; Ohtsu, F; Suzuki, T; Yoshioka, Y, 1992) |
| "Theophylline concentration was determined using HPLC." | 5.28 | Could saliva stand for plasma in theophylline monitoring in asthmatic children? Still a controversial problem. ( Bertin, L; d'Athis, P; de Blic, J; Gao, Y; Olive, G; Pons, G; Rey, E; Richard, MO; Scheinmann, P; Thiroux, G, 1992) |
| "for treatment of bronchial asthma." | 5.28 | A prospective trial using salivary-theophylline levels to guide asthma therapy. ( Mansfeld, J; Matthys, H; Virchow, C; Virchow, JC, 1992) |
| "The effects of long-term administration of theophylline on the pituitary-thyroid axis were investigated." | 5.28 | [Effects of long-term administration of theophylline on the pituitary-thyroid axis in asthmatics]. ( Fukutani, K, 1991) |
| "Erythromycin is an antibiotic extensively used worldwide which is also reported to have anti-inflammatory action." | 5.28 | Erythromycin reduces the severity of bronchial hyperresponsiveness in asthma. ( Miyatake, H; Satake, T; Suzuki, R; Takagi, K; Taki, F; Taniguchi, H, 1991) |
| " However an optimum dosage is hardly maintained in children by the present dose of a single tablet of 280 theophylline content." | 5.28 | [Initial experiences with "Oranienburg" slow-release theophylline in asthma therapy of children and adolescents]. ( Köhler, E; Schuster, R; Sollich, V; Thal, W; Walther, H, 1990) |
| "In standard clinical practice the pharmacokinetic profile of theophylline is monitored by measuring blood levels of the drug." | 5.28 | [Different rates of theophylline clearance. A statistical study of a group of asthmatics]. ( Ardizzi, A; Bernardi, W; Bianchi, M; Bruna, S; Gai, R; Galietti, F; Giorgis, GE; Oliaro, A, 1990) |
| " The average of relative bioavailability (3 cases) is 82%, 83%, 102%." | 5.28 | Sustained-release theophylline-uniphyllin in nocturnal asthmatics. ( Chiang, CD; Huang, WL; Jih, KS; Lin, TM; Mu, JY; Shih, WL; Yang, GY; Yiin, KT, 1989) |
| "On the case of a 13-year-old boy the authors demonstrate the possible non-linear relationship between long-term administration of theophylline and its serum concentrations which implies the danger of induction of limital to toxic concentrations of the drug in the blood stream when the doses are increased as required." | 5.28 | [Nonlinear theophylline kinetics in a boy on long-term theophylline therapy for bronchial asthma. Case report]. ( Dolezalová, K; Kopecká, J; Martínková, J, 1989) |
| " It seems advisable to use a higher dosage of the theophyllines and perhaps it is even better to combine them with other bronchodilators." | 5.27 | Pharmacokinetics and pharmacodynamics of a short- and long-acting theophylline medication (Theolair and Theolair retard) in normals and asthmatics. Part II: Lung function and side effects. ( Fokkens, J; Kreukniet, J; Serra, R; Utama, I, 1983) |
| " dosing due to unacceptable fluctuations." | 5.27 | Comparison of a new sustained-release theophylline preparation, TheoBeads, with Theo-Dur tablets in children with asthma. ( Gawchik, S; Kemp, JP; Meltzer, EO; Orgel, HA; Rooklin, AR; Tinkelman, DG; Welch, MJ, 1988) |
| " Therefore, we studied the bioavailability of a commonly prescribed slow-release theophylline formulation (Slo-Bid Gyrocaps), administered twice daily by sprinkling the beads on applesauce." | 5.27 | Bioavailability of a slow-release theophylline capsule given twice daily to preschool children with chronic asthma: comparison with liquid theophylline. ( Hendeles, L; Hill, M; McKenzie, M; Sallent, J; Stecenko, A, 1988) |
| "Theophylline was administered to a group of 17 volunteers and resulted in large reductions in plasma pyridoxal-5'-phosphate levels, while plasma pyridoxal levels and urinary 4-pyridoxic acid excretion were unaffected by theophylline therapy." | 5.27 | Vitamin B6 nutritional status in asthma: the effect of theophylline therapy on plasma pyridoxal-5'-phosphate and pyridoxal levels. ( Becker, PJ; Delport, R; Serfontein, WJ; Ubbink, JB; Walters, L, 1988) |
| "Increasing awareness of the exaggerated circadian rhythm in bronchomotor tone that causes most asthmatic patients to have increased respiratory symptoms in the early morning has resulted in a search for dosing strategies that will provide maximal bronchodilatory activity at the time of reduced bronchial patency." | 5.27 | Review of the North American experience with evening administration of Uniphyl tablets, a once-daily theophylline preparation, in the treatment of nocturnal asthma. ( Arkinstall, WW, 1988) |
| " However, bioavailability was complete both after single doses and during steady state." | 5.27 | Absorption characteristics of once-a-day slow-release theophylline preparation in children with asthma. ( Pedersen, S; Steffensen, G, 1987) |
| "In two studies, 25 diurnally active patients (6-17 years of age) were evaluated for day-night differences in serum theophylline concentration (STC) by frequent blood sampling over two consecutive 12-hr dosing intervals while being treated with Theo-Dur." | 5.27 | Clinical relevance of theophylline chronokinetics for asthmatic children. ( McGovern, JP; Scott, PH; Smolensky, MH, 1987) |
| "Theophylline concentration was measured in 137 simultaneously obtained paired specimens of plasma and saliva from 68 patients 2 1/2 months to 14 years of age treated with theophylline for asthma (dosage 20." | 5.27 | Monitoring theophylline therapy using citric acid-stimulated saliva in infants and children with asthma. ( Aviram, M; Ben-Zvi, Z; Gorodischer, R; Tal, A, 1987) |
| " In the intravenous administration of theophylline (5 mg/kg) to dogs, the theophylline half-life was 4." | 5.27 | Pharmacokinetics of theophylline in beagle dogs and asthmatic patients after multiple oral doses of sustained-release theophylline tablet formulation. ( Hasegawa, T; Mizukami, Y; Nosaka, H; Ogura, Y; Satake, T; Takagi, K, 1986) |
| " On a 12 hourly dosing schedule, mean dose was 25." | 5.27 | Pharmacokinetics of a sustained-release theophylline preparation in infants and preschool children with asthma. ( Isles, AF; Newth, CJ, 1985) |
| " The pharmacokinetic parameters (T 1/2, Kel, VD, Cl and AUC) did not differ between both groups." | 5.27 | [Pharmacokinetics of a new slow-release theophylline preparation in asthmatic children]. ( Caballero, L; Gil, MC; Mazón, A; Nieto, A, 1985) |
| " By generally applied measurements, including mean serum theophylline concentration, bioavailability over a single daytime dosing interval, and percent change in serum theophylline concentration over a single dosing interval, the preparations did not differ." | 5.27 | Theophylline absorption in young asthmatic children receiving sustained-release formulations. ( Haltom, JR; Szefler, SJ, 1985) |
| " This study suggests that this new sustained-release theophylline will be useful for the purpose of maintaining serum theophylline levels within the safe and therapeutic range with a twice daily dosing schedule." | 5.26 | Pharmacokinetics of Nuelin-SR 250 mg in asthmatic children: a new sustained-release theophylline. ( Liang, AY; Mitchell, EA, 1980) |
| "The oral dosage of theophylline was adjusted in order to maintain a serum level between 10 and 20 micrograms/ml." | 5.26 | [Determination of the mean dose of oral theophylline in asthmatic children (author's transl)]. ( Cabanas, R; Castro-Gago, M; Cortizo, E; Couselo, JM; Fuster, M; Peña, J; Tojo, R, 1982) |
| " Serum theophylline concentrations were determined and theophylline dosage (milligrams per kilogram body weight per day) was calculated in participants who had allegedly followed their medication regimen." | 5.26 | Theophylline compliance in adolescent patients with chronic asthma. ( Miller, KA, 1982) |
| "The authors propose a practical method for determining chronic oral theophylline dosage in children from slow intravenous theophylline infusion (45 minutes)." | 5.26 | [Adaptation of the oral dosage of theophylline to the asthmatic child. Value of a kinetic test by the intravenous route]. ( Albertini, M; Boutte, P; Lapalus, P; Mariani, R; Maurin, S, 1982) |
| " Available single-dose absorption data then were used to compare predicted fluctuations in serum concentration among nine formulations (18 brand names) for eight- and 12-hour dosing in an average child and adult (elimination half-lives of 3." | 5.26 | Relationship of formulation and dosing interval to fluctuation of serum theophylline concentration in children with chronic asthma. ( Hendeles, L; Weinberger, M; Wong, L, 1981) |
| "94 mg/kg) of anhydrous theophylline in 20 children aged 4 to 16 years, the pharmacokinetic characteristics (mean and standard deviation) were as follow: half life (T 1/2 6." | 5.26 | [Theophylline in childhood asthma. Pharmacokinetic and clinical study (author's transl)]. ( Barbier, Y; Bellon, G; Gilly, R; Plasse, JC; Satta, S, 1981) |
| " It reflects whether daily oral theophylline dosage in childhood asthma is below or within the therapeutic range." | 5.26 | Salivary theophylline estimation in the management of asthma in children. ( Hutchins, P; Lena, SM; Turner, P; Wood, CB, 1980) |
| "In order to assess the clinical impact of dose-dependent kinetics for theophylline, the relationship between serum concentration and daily dosage among patients under the care of the University of Iowa Pediatric Allergy and Pulmonary Service was examined." | 5.26 | Dose-dependent kinetics for theophylline: observations among ambulatory asthmatic children. ( Hendeles, L; Muir, K; Riegelman, S; Sarrazin, E; Weinberger, M, 1980) |
| " Using the mean values of the calculated pharmacokinetic parameters, rectal enemas providing a dose of theophylline of 6-8 mg/kg t." | 5.26 | Pharmacokinetics of theophylline in young children with asthma: comparison of rectal enema and suppositories. ( Bolme, P; Edlund, PO; Eriksson, M; Paalzow, L; Winbladh, B, 1979) |
| "Theophylline levels were measured 2 hours after each dose and were satisfactory in both schedules." | 5.26 | Effect of practical timing of dosage on theophylline blood levels in asthmatic children treated with choline theophyllinate. ( Baillie, E; Godfrey, S; McKenzie, SA, 1978) |
| " Using a daily dosage of up to 16 mg/kg bodyweight more than 80% of children showed definite improvement leading to prevention or significant reduction of acute attacks and clearly reduced dyspnoeic states between attacks." | 5.25 | [Long-term out-patient treatment of children with asthma with a theophylline-ephedrine-hydroxyzine combination (author's transl)]. ( Götz, M, 1975) |
| "To evaluate and contrast the therapeutic effect and safety of fluticasone aerosol combined with theophylline tablets in patients with moderate to severe asthma, compared with salmeterol/fluticasone propionate aerosol." | 5.22 | Intervention Studies of Inhaled Corticosteroids Combined with Long-acting Theophylline or Long-acting β ( Chen, P; Dai, A; Kong, L; Shang, S; Wang, Y, 2016) |
| "We assessed the pulmonary function in asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide in a pilot group." | 5.19 | Pulmonary function assessment in mild to moderate persistent asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide: a randomized controlled study. ( Ilango, K; Nageswari, AD; Rajanandh, MG, 2014) |
| "To explore the therapeutic efficacies of inhaled corticosteroids (ICS) plus low-dose theophylline for moderate bronchial asthma." | 5.17 | [Clinical efficacies of inhaled corticosteroids plus theophylline in the treatment of bronchial asthma]. ( Chen, ZC; Ding, JJ; Feng, KQ; Lin, XH; Qian, HY; Wang, J, 2013) |
| "To compare the efficacy of theophylline plus salmeterol/fluticasone propionate combination product (SFC) with SFC plus placebo in asthmatic patients." | 5.17 | Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma. ( Ding, X; Hu, S; Huang, Y; Liu, M; Nie, H; Zhang, G, 2013) |
| "Whether the additive effects of the tulobuterol patch (TP), the world's first transdermal beta2-agonist preparation, are useful in asthma patients receiving inhaled corticosteroid (ICS) is unclear." | 5.14 | Effects of the addition of Beta2-agonist tulobuterol patches to inhaled corticosteroid in patients with asthma. ( Haruta, Y; Hozawa, S; Terada, M; Yamakido, M, 2009) |
| "We used a secondary observational analysis of pregnant women with mild and moderate-severe asthma enrolled in a prospective observational cohort study of asthma in pregnancy and a randomized clinical trial (RCT) comparing inhaled beclomethasone and oral theophylline." | 5.14 | The effect of active and passive household cigarette smoke exposure on pregnant women with asthma. ( Caritis, SN; Conway, DL; Dombrowski, MP; Landon, M; Lindheimer, M; Miodovnik, M; Momirova, V; Newman, RB; O'Sullivan, MJ; Rouse, DJ; Schatz, M; Sheffield, J; Varner, MW; Wapner, RJ; Wise, R, 2010) |
| "To compare the efficacy and safety of the salmeterol/fluticasone propionate combination product with concurrent sustained release theophylline plus fluticasone propionate in adult Japanese patients with persistent asthma." | 5.13 | Comparison of salmeterol/fluticasone propionate (FP) combination with FP+sustained release theophylline in moderate asthma patients. ( Adachi, M; Aizawa, H; Ishihara, K; Nakashima, M; Ohta, K; Sano, Y; Taniguchi, H, 2008) |
| "We investigated 28 single nucleotide polymorphisms in CRHR2 for associations with acute bronchodilator response to albuterol in 607 Caucasian asthmatic patients recruited as part of the Childhood Asthma Management Program." | 5.13 | Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. ( Hanrahan, JP; Irvin, CG; Lange, C; Lasky-Su, J; Lazarus, R; Lima, JJ; Litonjua, AA; Poon, AH; Tantisira, KG; Weiss, ST; Xu, J, 2008) |
| "Data were collected in sub-study of a large multi-center randomized double-masked controlled trial of mild-moderate asthmatics evaluating the effect of low-dose theophylline on asthma control in comparison to montelukast and placebo." | 5.13 | Sleep quality in asthma: results of a large prospective clinical trial. ( Mastronarde, JG; Olopade, CO; Scharf, SM; Shade, DM; Wise, RA, 2008) |
| " Therefore, a 12-week randomized double-blind placebo-controlled clinical study was conducted to investigate the efficacy of a plant-based formulation (DCBT4567-Astha-15) in comparison with oral salbutamol, salbutamol + theophylline and a matching placebo in patients with reversible asthma." | 5.12 | Plant-based formulation for bronchial asthma: a controlled clinical trial to compare its efficacy with oral salbutamol and theophylline. ( Deivanayagam, CN; Krishnarajasekar, OR; Lakshmisubramanian, S; Murali, PM; Nalini, K; Perumal, T; Rajasekaran, S, 2006) |
| "To observe the role of theophylline in relieving airway symptoms and inflammation in patients with mild asthma." | 5.12 | [Clinical efficacy of low-dose oral theophylline for treating mild asthma]. ( Huang, SD; Pan, QH; Tian, LQ; Yang, J; Zhang, SY, 2006) |
| "A cohort study of participants in two trials of the American Lung Association-Asthma Clinical Research Centers: 2,031 asthmatics in the Safety of Inactivated Influenza Vaccine in Asthma in Adults and Children (SIIVA) trial and 488 asthmatics in the Effectiveness of Low Dose Theophylline as Add-on Treatment in Asthma (LODO) trial." | 5.12 | Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function. ( Dixon, AE; Holbrook, JT; Irvin, CG; Kaminsky, DA; Shade, DM; Wise, RA, 2006) |
| " Obese and non-obese subjects with asthma had similar airflow limitation and bronchodilator responsiveness, but obese participants had increased sleep disturbance and gastroesophageal reflux disease, higher cytokine levels, and a trend towards increased exacerbations when treated with theophylline." | 5.12 | Effect of obesity on clinical presentation and response to treatment in asthma. ( Allayee, H; Cohen, RI; Dixon, AE; Holbrook, JT; Irvin, CG; Lima, JJ; Shade, DM; Skloot, GS; Smith, LJ; Wise, RA, 2006) |
| "The purpose of this study was to investigate the efficacy and safety of salmeterol combined with high-dose ICSs plus theophylline in severe asthma." | 5.12 | Effects of salmeterol in patients with persistent asthma receiving inhaled corticosteroid plus theophylline. ( Aizawa, H; Fukuyama, S; Inoue, H; Kanaya, A; Komori, M; Matsumoto, K; Matsumoto, T; Matsumura, M; Moriwaki, A; Nakanishi, Y; Nakano, T; Tsuda, M; Yoshida, M, 2007) |
| "We conducted a randomized, double-masked, placebo-controlled trial in 489 participants with poorly controlled asthma randomly assigned to placebo, theophylline (300 mg/d), or montelukast (10 mg/d)." | 5.12 | Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. ( , 2007) |
| "The results indicate that montelukast added to low-dose ICS is an effective and safe option for the treatment of asthma in children." | 5.12 | A randomized open-label comparative study of montelukast versus theophylline added to inhaled corticosteroid in asthmatic children. ( Katsunuma, T; Kondo, N; Morikawa, A; Odajima, Y, 2006) |
| "Asthmatic patients receiving montelukast and, to some extent, low-dose theophylline have lower levels of CVD-associated inflammatory biomarkers and lipid levels." | 5.12 | The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. ( Allayee, H; Conti, DV; Hartiala, J; Irvin, CG; Lee, W; Lima, JJ; Mehrabian, M, 2007) |
| "In a study comparing low-dose theophylline to montelukast in poorly controlled asthmatics, 285 subjects consented to be screened for alpha-1 antitrypsin deficiency." | 5.12 | Prevalence of alpha-1 antitrypsin deficiency in poorly controlled asthma--results from the ALA-ACRC low-dose theophylline trial. ( Brantly, ML; Eden, E; Holbrook, JT; Turino, GM; Wise, RA, 2007) |
| "This study was undertaken to compare the efficacy of inhaled beclomethasone dipropionate to oral theophylline for the prevention of asthma exacerbation(s) requiring medical intervention." | 5.11 | Randomized trial of inhaled beclomethasone dipropionate versus theophylline for moderate asthma during pregnancy. ( Caritis, SN; Conway, DL; Dombrowski, MP; Hauth, JC; Landon, M; Leveno, KJ; Lindheimer, M; Mabie, W; McNellis, D; Meis, P; Miodovnik, M; Newman, RB; O'Sullivan, MJ; Schatz, M; Thom, EA; Varner, MW; Wapner, RJ; Wise, R, 2004) |
| "The effects of high-dose fluticasone propionate therapy on dynamic cortisol stimulation in severe asthma are unknown." | 5.11 | Effects of high-dose inhaled fluticasone propionate on the hypothalamic-pituitary-adrenal axis in asthmatic patients with severely impaired lung function. ( Bates, CE; Cowan, LM; Currie, GP; Lee, DK; Lipworth, BJ; McFarlane, LC, 2004) |
| "Inhaled corticosteroids, leukotriene receptor antagonists, and theophylline are recommended for the treatment of mild persistent asthma." | 5.11 | Effects of different anti-asthmatic agents on induced sputum and eosinophil cationic protein in mild asthmatics. ( Basyigit, I; Boyaci, H; Ilgazli, A; Kacar Ozkara, S; Ozkarakas, O; Yildiz, F, 2004) |
| "The present study was designed to evaluate the efficacy and safety of intravenously administered theophylline (IAT) for the treatment of an acute exacerbation of bronchial asthma." | 5.11 | Efficacy and safety of intravenous theophylline administration for treatment of mild acute exacerbation of bronchial asthma. ( Inoue, H; Kobayashi, H; Pian, HD; Tanifuji, Y; Yamauchi, K; Yoshida, T, 2005) |
| "The objective of this study was to compare the efficacy and safety of the second controller medications (long-acting beta2-agonist, leukotriene receptor antagonist and sustained-release theophylline) used in addition to inhaler corticosteroid treatment in moderate persistent asthma." | 5.10 | Comparison of second controller medications in addition to inhaled corticosteroid in patients with moderate asthma. ( Calişir, HC; Ogretensoy, M; Tunçtan, B; Yurdakul, AS, 2002) |
| "Twenty-four patients with mild-to-moderate asthma were studied using a randomized crossover design with the following three treatment blocks: (1) beclomethasone, 100 microg/d, alone for the first 2 weeks followed by 400 microg/d alone for the next 2 weeks; (2) beclomethasone, 100 microg/d, followed by 400 microg/d, with the addition of zafirlukast, 20 mg bid; (3) beclomethasone, 100 microg/d, followed by 400 microg/d, with the addition of theophylline, 200 to 300 mg bid." | 5.10 | Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma. ( Dempsey, OJ; Fowler, SJ; Kennedy, G; Lipworth, BJ; Wilson, A, 2002) |
| "We analyzed the effect of genetic polymorphisms in the 5'-flanking region to the first intron of the CYP1A2 gene on theophylline metabolism in 75 Japanese patients with asthma and 159 healthy Japanese volunteers." | 5.10 | Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma. ( Kawano, T; Kinoshita, M; Kohno, S; Matsuse, H; Mitsuta-Izaki, K; Obase, Y; Saeki, S; Shimoda, T; Tomari, SY, 2003) |
| "The purpose of this study was to compare the efficacy and safety of the inhaled budesonide, sustained-release theophylline and montelukast, a leukotriene receptor antagonist, in patients with mild persistent asthma." | 5.10 | Comparative efficacy of once-daily therapy with inhaled corticosteroid, leukotriene antagonist or sustained-release theophylline in patients with mild persistent asthma. ( Eren, A; Sipit, T; Taci, N; Yurdakul, AS, 2003) |
| " Patients kept records of peak flow meter (PFM) measurements, asthma attack rate and beta-2-agonist use (albuterol)." | 5.10 | Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma -- a double-blind randomized placebo-controlled multicentre clinical trial. ( Chervinsky, P; Goldstein, MF, 2002) |
| "The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown, but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling asthma." | 5.10 | A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. ( Adcock, IM; Barnes, PJ; Caramori, G; Chung, KF; Cosio, B; Ito, K; Lim, S, 2002) |
| "A sustained-release formulation of theophylline with an innovative release mechanism was evaluated in adult asthmatics." | 5.09 | Comparative pharmacodynamic-pharmacokinetic correlation of oral sustained-release theophylline formulation in adult asthmatics. ( Devarajan, PV; Parmar, DV; Sule, PN, 1999) |
| "Thus, in the theophylline-administered group, slow-release theophylline, Theolong, was effective in treating asthma, with anti-inflammatory effects on inflammatory cells besides its bronchodilator action." | 5.09 | Suppression of airway inflammation by theophylline in adult bronchial asthma. ( Doi, M; Hirose, M; Horiguchi, T; Imazu, M; Kasahara, J; Miyazaki, J; Sasaki, Y; Shiga, M; Tachikawa, S, 1999) |
| "To compare the efficacy, safety, and effects on sleep quality of salmeterol and extended-release theophylline in patients with nocturnal asthma." | 5.09 | Salmeterol vs theophylline: sleep and efficacy outcomes in patients with nocturnal asthma. ( Mende, CN; Petrocella, VJ; Rickard, KA; Wiegand, L; Yancey, SW; Zaidel, G; Zwillich, CW, 1999) |
| "Fluticasone propionate 880 microg/day improved lung function and quality of life in adolescents with moderate-to-severe asthma when compared with flunisolide 1500 microg/day." | 5.09 | Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma. ( Eid, N; Goldsmith, LJ; Howell, L; Sheikh, S, 1999) |
| "In order to evaluate the effects of theophylline on airway inflammation, we investigated 48 subjects with mild and moderate asthma." | 5.09 | Once-daily theophylline reduces serum eosinophil cationic protein and eosinophil levels in induced sputum of asthmatics. ( Aizawa, H; Hara, N; Inoue, H; Iwanaga, T; Matsumoto, K; Takahashi, N; Takata, S; Yoshida, M, 2000) |
| "The authors investigated whether theophylline metabolism is decreased in asthmatic patients and what condition may be related to its reduction." | 5.09 | Higher incidence of elevated body temperature or increased C-reactive protein level in asthmatic children showing transient reduction of theophylline metabolism. ( Akimoto, Y; Kobayashi, S; Koitabashi, Y; Matuda, T; Miyoshi, T; Okano, Y; Tateishi, T; Yamaguchi, A, 2000) |
| "Theophylline has been used for several decades in the treatment of asthma." | 5.09 | Theophylline pharmacokinetics with concomitant steroid and gold therapy. ( Almeida, AM; Caramona, MM; Falcão, AC; Rocha, MJ, 2000) |
| "The precise mechanism of action of theophylline in asthma is not fully understood but recent data have drawn attention to its potential anti-inflammatory effect." | 5.09 | Effect of a 4-week treatment with theophylline on sputum eosinophilia and sputum eosinophil chemotactic activity in steroid-naive asthmatics. ( Bettiol, J; Cataldo, D; Henquet, M; Louis, R; Radermecker, M; Sele, J, 2000) |
| "Theophylline is widely used in the treatment of asthma, and there is evidence that theophylline has anti-inflammatory or immunomodulatory effects." | 5.09 | Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice. ( Barnes, PJ; Chung, KF; Gordon, D; Jatakanon, A; Lim, S; Macdonald, C, 2000) |
| "Theophylline is well-established in the management of asthma, and there is some evidence of an antiinflammatory effect in asthma." | 5.09 | Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma. ( Adcock, I; Barnes, PJ; Caramori, G; Carramori, G; Chung, KF; Jatakanon, A; Keller, A; Lim, S; Oliver, B; Tomita, K, 2001) |
| "To investigate whether low dose theophylline has an anti-inflammatory effect in asthma." | 5.09 | Effect of theophylline on airway inflammation in asthma. ( Li, QQ; Tu, HY; Yang, J, 2001) |
| "The aim of present study was to evaluate clinical, functional, and anti-inflammatory effects of inhaled budesonide and oral theophylline treatments in patients with mild to moderate asthma." | 5.09 | Efficacy of inhaled budesonide and oral theophylline in asthmatic subjects. ( Akkaya, E; Baran, R; Ece, F; Erkan, F; Morali, T; Yilmaz, A, 2001) |
| "We studied the efficacy of theophylline chronotherapy for nocturnal asthma using the changes of the circadian rhythms in peak expiratory flow rate (PEF)." | 5.09 | Theophylline chronotherapy of nocturnal asthma using bathyphase of circadian rhythm in peak expiratory flow rate. ( Burioka, N; Igishi, T; Miyata, M; Sako, T; Shimizu, E; Suyama, H; Tomita, K, 2001) |
| "The purpose of this study was to determine whether the addition of extended-release theophylline to the daily treatment regimen of inhaled beta 2-agonist users would result in decreased use of beta 2-agonist while maintaining similar efficacy for treatment of asthma." | 5.08 | Efficacy of once daily extended-release theophylline in decreasing the use of inhaled beta 2-agonists in stable, mild-to-moderate asthma patients. ( Cefali, EA; Dockhorn, RJ; Edwards, TB; Fiddes, RA; Grossman, J; Hassanein, RS; Menendez, R; Southern, DL; Wagner, DE, 1995) |
| " Based on the data from a 24-h lung function study in 20 adult patients with asthma, the corresponding values were separately compared at baseline and under two theophylline treatments, one being administered twice daily and the other once daily." | 5.08 | Measurements of morning and evening airflow grossly underestimate the circadian variability of FEV1 and peak expiratory flow rate in asthma. ( D'Alonzo, GE; Keller, A; Steinijans, VW, 1995) |
| "In 61 patients with nocturnal asthma, the effects of budesonide, an inhaled steroid (Pulmicort; 200 micrograms twice daily), long-acting theophylline (Theodur; 200 mg twice daily), and their combination were compared." | 5.08 | A double-blind comparison of inhaled budesonide, long-acting theophylline, and their combination in treatment of nocturnal asthma. ( Permpikul, C; Suthamsmai, T; Wong, E; Youngchaiyud, P, 1995) |
| "In order to assess whether treatment with oral slow-release theophylline prevents early (EAR) and/or late (LAR) airway responses to allergen, we treated six asthmatic subjects with either placebo or oral theophylline (350 mg b." | 5.08 | Oral slow-release theophylline does not prevent early and late asthmatic response to allergen in sensitized subjects. ( Bacci, E; Bancalari, L; Carrara, M; Dente, FL; Di Franco, A; Giannini, D; Giuntini, C; Paggiaro, PL; Vagaggini, B, 1995) |
| "Theophylline is the most widely used anti-asthma drug worldwide and is classified as a bronchodilator, although there is increasing evidence that it may have immunomodulatory effects." | 5.08 | Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy. ( Barnes, PJ; Chung, KF; Dominguez, M; Kidney, J; Rose, M; Taylor, PM, 1995) |
| "To compare a group of hospitalized asthmatic children taking theophylline with a similar group of hospitalized nonasthmatic children on standardized measures of distractibility, attention, hyperactivity, and academic achievement." | 5.08 | Theophylline effects on cognition, behavior, and learning. ( McGeady, SJ; Weldon, DP, 1995) |
| " Responses to inhaled allergen were measured in 16 subjects with allergic asthma (age range, 18 to 35 years) after 7 days of treatment with either placebo, once daily slow-release theophylline producing a mean +/- SD serum concentration of 16 +/- 5 micrograms/ml during the late phase, or 2 mg of cromolyn administered by MDI four times daily." | 5.08 | Theophylline attenuation of airway responses to allergen: comparison with cromolyn metered-dose inhaler. ( Blake, K; Delafuente, J; Harman, E; Hendeles, L; Huang, D; O'Brien, R, 1995) |
| " Altogether, 2772 serum theophylline concentrations were obtained from 131 normal subjects and 306 patients suffering from chronic asthma or chronic obstructive pulmonary disease who participated in the phase I, II, and III clinical trials in Japan." | 5.08 | Population pharmacokinetics of theophylline. III. Premarketing study for a once-daily administered preparation. ( Hori, R; Iwai, T; Iwakawa, S; Komada, F; Maekawa, H; Okumura, K; Shimizu, T; Tanigawara, Y, 1995) |
| "We evaluated this potential effect of theophylline in eight patients with nocturnal asthma." | 5.08 | Theophylline: potential antiinflammatory effects in nocturnal asthma. ( Kraft, M; Martin, RJ; Torvik, JA; Trudeau, JB; Wenzel, SE, 1996) |
| "Theophylline has been shown by several investigators to attenuate the late asthmatic response (LAR) to inhaled allergen, suggesting that it has anti-inflammatory or immunomodulatory properties." | 5.08 | Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics. ( Costello, J; Jaffar, ZH; Page, C; Sullivan, P, 1996) |
| " Twenty seven patients (20 to 64 years) with acute asthma attack were given aminophylline intravenously to obtain a theophylline concentration between 10 and 20 micrograms/ml." | 5.08 | Significance of the therapeutic range of serum theophylline concentration in the treatment of an attack of bronchial asthma. ( Murata, M; Nagasawa, K; Nakahara, Y; Ohtsu, F; Suzuki, T, 1996) |
| "The study was designed to determine whether theophylline would inhibit the late asthmatic response by reducing neutrophil activation and subsequent superoxide production." | 5.08 | Theophylline's effect on neutrophil function and the late asthmatic response. ( Borish, L; Kraft, M; Martin, RJ; Pak, J, 1996) |
| "To determine whether controlled-release theophylline inhibits the development of airway obstruction and/or airway hyperresponsiveness early in the morning, we examined 18 subjects reporting recurrent nocturnal asthma." | 5.08 | Controlled-release theophylline inhibits early morning airway obstruction and hyperresponsiveness in asthmatic subjects. ( Boschetto, P; Crescioli, S; Dal Carobbo, A; Fabbri, LM; Hurst, TS; Maestrelli, P; Parise, G; Santagada, T; Steinijans, VW, 1996) |
| "The inhaled corticosteroid, fluticasone propionate, was compared with the oral bronchodilator theophylline in the maintenance treatment of asthma." | 5.08 | Fluticasone propionate compared with theophylline for mild-to-moderate asthma. ( Baker, KA; Galant, SP; Kellerman, DJ; Lawrence, M; Meltzer, EO; Tomasko, M, 1996) |
| "To examine the effects of once-daily, sustained-release theophylline on sleep patterns in nocturnal asthmatics." | 5.08 | An evaluative study of the short-term effects of once-daily, sustained-release theophylline on sleep in nocturnal asthmatics. ( Driver, HS; Richardt, D, 1996) |
| " In the present study, theophylline concentration in plasma was measured by the Biotrack 516 system for theophylline, a newly developed automated system based on the turbidimetric latex agglutination inhibition reaction, using whole blood samples obtained from 35 asthmatic patients receiving chronic theophylline therapy." | 5.08 | Clinical application of the Biotrack 516 system for determination of theophylline by a turbidimetric latex agglutination inhibition reaction. ( Hasegawa, T; Nabeshima, T; Nadai, M; Takagi, K; Tsunekawa, Y; Yamaki, K, 1996) |
| "The anti-inflammatory effects of oral theophylline on cells in bronchial biopsies of symptomatic atopic asthmatic subjects were investigated." | 5.08 | Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study. ( Djukanovic, R; Finnerty, JP; Holgate, ST; Lee, C; Madden, J; Wilson, S, 1996) |
| "The aim of this study was to compare the clinical efficacy of salmeterol versus theophylline in the treatment of moderate-to-severe asthma." | 5.08 | Comparison of inhaled salmeterol and individually dose-titrated slow-release theophylline in patients with reversible airway obstruction. European Study Group. ( Di Franco, A; Giannini, D; Paggiaro, PL; Testi, R, 1996) |
| "Bronchodilator effect and toxicity of theophylline 300 mg twice a day (E1), Salbutamol 4 mg tid (E2), their combination in higher (200/4 mg, E3), and lower doses (100/2 mg E4), and placebo calcium lactate (300 mg) tid (E5) were compared in 30 patients with bronchial asthma in a randomized cross over trial." | 5.08 | [Sympathomimetics and theophylline: combined use?]. ( Alvarez Castro, MR; Alvarez Sintes, R, 1995) |
| "Patients with chronic asthma are often treated with sustained-release theophylline preparations." | 5.08 | [Usefulness of "Biotrack Theophylline kit" for measuring serum theophylline concentration in patients with chronic asthma]. ( Iwata, T, 1996) |
| "To compare 24-h and 12-h delayed-release theophylline in asthmatic patients, in terms of clinical stability and respiratory function, side effects and required dose, clinical tolerance and plasma concentrations." | 5.08 | [Theophyllines of 12- and 24-hour sustained-release. Comparative study]. ( Anguera, A; de Gracia, J; Mayordomo, C; Morell, F; Muñoz, X; Pou, L; Vendrell, M, 1996) |
| "Nocturnal cough and wheeze are common in asthma and often treated with beta2 agonists or theophyllines." | 5.08 | Inhaled salmeterol or oral theophylline in nocturnal asthma? ( Douglas, NJ; Engleman, HM; Fitzpatrick, MF; Mackay, TW; Selby, C; Sime, PM, 1997) |
| "These data suggest that for children with moderate to severe asthma exacerbation, hospital admission rates are similar in children given oral methylprednisolone and those given i." | 5.08 | Intravenous versus oral corticosteroids in the management of acute asthma in children. ( Barnett, PL; Baskin, M; Caputo, GL; Kuppermann, N, 1997) |
| " The present study was undertaken to compare the therapeutic effects of sustained release theophylline and a conventional low dose oral fenoterol in patients with asthma." | 5.08 | Oral fenoterol versus sustained release theophylline in adult asthmatics. ( Almagro, J; Andrade, RJ; Hidalgo Sanchez, R; Lucena, MI; Sanchez de la Cuesta, F, 1997) |
| "We investigated the effect of theophylline administration on circulating vitamin levels in children with asthma." | 5.08 | Relation between theophylline and circulating vitamin levels in children with asthma. ( Arakawa, H; Maeda, S; Mochizuki, H; Morikawa, A; Shimizu, T; Tokuyama, K, 1996) |
| "Although theophylline is recommended by current guidelines for the management of asthma in patients with persistent symptoms, theophylline has a narrow therapeutic index, requiring individual dose titration and regular monitoring of serum theophylline concentrations to avoid adverse effects." | 5.08 | Salmeterol versus theophylline in the treatment of asthma. ( Cox, FM; Emmett, A; Pollard, SJ; Spector, SL; Yancey, SW, 1997) |
| "The aim of the present study was to compare the efficacy and the tolerability of salmeterol and theophylline in patients with nocturnal asthma." | 5.08 | [Therapy of nocturnal asthma: salmeterol versus nocturnal administration of retard theophylline--comparison of effectiveness and tolerance]. ( Braun, H; Koper, I; Leutz, M; Schlimmer, P; Sybrecht, GW; Ukena, D, 1997) |
| "In comparison to beta-agonist drugs, which are the primary bronchodilator drugs in current use in asthma, both oral theophylline and inhaled ipratropium have a weaker bronchodilating action in asthma." | 5.08 | The effects of the combination of inhaled ipratropium and oral theophylline in asthma. ( Burki, NK, 1997) |
| "The safety and tolerance of intravenous theophylline in asthmatic patients was investigated." | 5.08 | [Clinical evaluation of the isotonic solution of theophylline for intravenous injection]. ( Chazan, R; Droszcz, W; Grubek-Jaworska, H; Martusewicz, M; Tymińska, K, 1996) |
| "Inhaled glucosteroids and oral theophylline are widely used to treat asthma." | 5.08 | A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma. ( Barnes, PJ; Chung, KF; Evans, DJ; O'Connor, BJ; Taylor, DA; Zetterstrom, O, 1997) |
| "The effect of a single oral dose of cilostazol on BHR was studied in 10 elderly patients with clinically stable asthma, with a mean age of 59." | 5.08 | Effect of a phosphodiesterase 3 inhibitor, cilostazol, on bronchial hyperresponsiveness in elderly patients with asthma. ( Fujimura, M; Hashimoto, T; Kamio, Y; Matsuda, T; Myou, S, 1997) |
| "Zileuton, a leukotriene pathway inhibitor, was compared with slowly absorbed theophylline in a randomized, double-blind study of patients with chronic asthma." | 5.08 | A randomized controlled trial comparing zileuton with theophylline in moderate asthma. The Zileuton Study Group. ( Dubé, LM; Lancaster, JF; Petty, T; Schwartz, HJ; Swanson, LJ, 1998) |
| "Inhaled corticosteroids and oral theophylline are effective treatments for moderate asthma." | 5.08 | Aerosol beclomethasone dipropionate spray compared with theophylline as primary treatment for chronic mild-to-moderate asthma. The American Academy of Allergy, Asthma and Immunology Beclomethasone Dipropionate-Theophylline Study Group. ( Li, JT; Nelson, HS; Offord, KP; Reed, CE; Tinkelman, DG, 1998) |
| "The aim of the study was to compare the influence of theophylline 300 on eosinophil cationic protein (ECP)level in serum in asthmatic patients Theophylline was given twice a day." | 5.08 | [The effect of an isotonic solution of theophylline 300 on eosinophil cationic protein levels]. ( Boros, MM; Chazan, R; Chazan-Polanowska, E; Droszcz, W; Grubek-Jaworska, H, 1997) |
| "This was a multicenter, randomized, double-blind, parallel-groups study in which 102 asthmatic patients were assigned to one of two treatments: beclomethasone three times daily or theophylline twice daily." | 5.08 | Neuropsychological and behavioral changes in asthmatic children treated with beclomethasone dipropionate versus theophylline. ( Bender, BG; DuHamel, T; Iklé, DN; Tinkelman, D, 1998) |
| "Previous studies evaluating spirometric values and symptoms have shown that once daily theophylline administered in the evening produces greater stabilisation of the airway function in asthmatic patients than the prototype theophylline given twice a day." | 5.08 | Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients. ( Biasin, C; Bonazza, L; Ferrari, M; Lampronti, G; Lo Cascio, V; Nacci, P; Olivieri, M; Talamini, G, 1997) |
| "The anti-asthmatic effects of theophylline may supplement those of inhaled steroids in asthma." | 5.08 | Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma. ( Harnest, U; Keller, A; Leichtl, S; Magyar, P; Rathgeb, F; Sakalauskas, R; Steffen, H; Steinijans, VW; Ukena, D; Vetter, N, 1997) |
| " The purpose of this work was to compare two methods used to quantify plasmatic levels of theophylline in asthmatic patients as support to choose the best method." | 5.08 | Plasmatic levels of theophylline in asthmatic patients. Comparative evaluations of two different methods. ( Flores-Pérez, J; Juárez-Olguín, H; Lares-Asseff, I, 1998) |
| "We investigated whether the deterioration in asthma control reported following cessation of theophylline was due to tolerance to theophylline." | 5.08 | The airway effects of stopping regular oral theophylline in patients with asthma. ( Bennett, JA; Pavord, ID; Tattersfield, AE; Thompson Coon, J; Wilding, PJ, 1998) |
| "Depending on the administration method, highly effective therapeutic variable serum concentrations (VSC) of theophylline can be attained only in the time range of frequent asthma attacks." | 5.08 | Comparative study on the clinical efficacy of theophylline variable serum concentrations therapy and round-the-clock therapy. ( Murata, M; Nagasawa, K; Nakahara, Y; Ohtsu, F; Suzuki, T, 1998) |
| "The role of aminophylline (ethylene diamine salt of theophylline) in the treatment of acute exacerbation of asthma has not been well established in children." | 5.08 | Efficacy of aminophylline in the treatment of acute asthma exacerbation in children. ( Barlan, IB; Başaran, MM; Dai, A; Nuhoğlu, Y, 1998) |
| "The aim of the present multicentre, open, randomized, parallel group study was to evaluate the efficacy and safety of salmeterol versus theophylline in asthmatic patients." | 5.08 | Long-term treatment of asthmatic patients with salmeterol vs slow-release theophylline. ( Martini, T; Nutini, S; Righi, R, 1998) |
| "A pilot study in 14 patients with mild asthma was performed to study the anti-inflammatory efficacy of theophylline (CAS 58-55-9)." | 5.08 | [The anti-inflammatory action of an oral sustained-release theophylline preparation. Results of a clinical pilot study with low dosages]. ( Bodner, A; Hens, C; Moser, C; Oster, H, 1998) |
| "Theophylline is a bronchodilator and immunomodulator drug which has recently been demonstrated to attenuate the recruitment and activation of inflammatory cells into lungs of asthmatics." | 5.08 | Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects. ( Costello, JF; Cotter, T; Kilfeather, S; Page, CP; Spina, D; Sullivan, P, 1998) |
| "The anti-asthmatic effect of theophylline may supplement those of inhaled steroids in asthma." | 5.08 | [Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma]. ( Harnest, U; Keller, A; Leichtl, S; Magyar, P; Rathgeb, F; Sakalauskas, R; Steffen, H; Steinijans, VW; Ukena, D; Vetter, N, 1998) |
| "Theophylline has been used as a bronchodilator in acute and chronic asthma management, although there is accumulating evidence that it may have anti-inflammatory effects." | 5.08 | Effect of theophylline withdrawal on airway inflammation in asthma. ( Adachi, M; Akabane, T; Hashimoto, T; Kihara, N; Kobayashi, H; Kohno, Y; Minoguchi, K; Mita, S; Miyamoto, M; Oda, N; Wada, K; Yokoe, T, 1998) |
| "To evaluate the effect of controlled-release theophylline given with the evening meal on the immediate asthmatic response (IAR) and LAR following nighttime antigen challenge in patients with mild atopic asthma." | 5.08 | Theophylline inhibits the late asthmatic response to nighttime antigen challenge in patients with mild atopic asthma. ( Busse, WW; Jarjour, NN; Lacouture, PG, 1998) |
| "The nonspecific phosphodiesterase inhibitor theophylline, widely used in asthma therapy, may cause a decrease in inflammatory responses of airways." | 5.08 | Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro. ( Berends, C; de Monchy, JG; Dijkhuizen, B; Kauffman, HF; Spoelstra, FM, 1998) |
| "Theophylline has been used as a bronchodilator in acute and chronic asthma management but recent evidences suggest that it has anti-inflammatory effects." | 5.08 | [Effect of slow-release theophylline on airway inflammation in bronchial asthma]. ( Adachi, M; Akiyama, K; Kokubu, F; Minoguchi, K; Mita, S; Sano, Y; Suzuki, H; Yasuhara, H, 1998) |
| "The purpose of this study is to determine whether theophylline provides clinical benefits in the hospitalized children with asthma attack." | 5.08 | [Evaluation of theophylline in children hospitalized with asthma attack]. ( Kodama, S; Miyoshi, M; Sakurai, T, 1998) |
| "Eight patients with mild extrinsic asthma participated in a double-blind randomized intraindividual cross-over study involving 6 weeks' treatment with twice daily oral theophylline (2 x 1 capsules = 800 mg/day Cronasma 400) and 6 weeks' treatment with twice daily inhaled budesonide (2 x 2 puffs = 0." | 5.07 | Theophylline vs. budesonide in the treatment of mild-to-moderate bronchial asthma. ( Herceg, R; Matthys, H; Müller, S, 1994) |
| "This study was designed to investigate the effect of sustained-release theophylline therapy on serum pyridoxal concentration in children with bronchial asthma." | 5.07 | [Serum pyridoxal concentration in children during theophylline therapy for bronchial asthma]. ( Fujino, M; Hiraga, Y; Inaba, J; Kobayashi, K; Tanaka, I, 1994) |
| "Theophylline, in addition to its bronchodilator effect, may attenuate inflammation in asthma." | 5.07 | Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. ( Bekir, S; Costello, J; Jaffar, Z; Jeffery, P; Page, C; Sullivan, P, 1994) |
| "The impact of theophylline therapy on neuropsychological (NP) function in adult asthmatics is unclear." | 5.07 | Effect of chronic theophylline therapy on brain blood flow and function in adult asthmatics. ( Anderson, R; Bowton, DL; Stump, DA, 1994) |
| "Patients were recruited from 18 centers and 4 countries to participate in a 1-month double-blind comparison of enprofylline or theophylline in the treatment of asthma and were subsequently maintained on a regimen with the assigned medication for a further 11 months." | 5.07 | Long-term xanthine therapy of asthma. Enprofylline and theophylline compared. International Enprofylline Study Group. ( Chapman, KR; Kallen, A; Ljungholm, K, 1994) |
| "This study compared the efficacy of weekly oral administration of methotrexate and placebo in treatment of 24 subjects with chronic glucocorticosteroid-dependent asthma." | 5.07 | Comparison of oral pulse methotrexate with placebo in the treatment of severe glucocorticosteroid-dependent asthma. ( Diaz, JD; Ledford, DK; Lockey, RF; Seleznick, MJ; Stewart, GE; Trudeau, WL, 1994) |
| "Administration of theophylline to asthmatic children is frequently associated with an adverse influence on their behavior." | 5.07 | Administration of half-dose theophylline together with ketotifen to asthmatic children--a double-blind, placebo-controlled study. ( Amir, J; Lerman, M; Malik, H; Varsano, I; Volovitz, B, 1994) |
| "A randomized trial of long-acting theophylline drugs theopek taken twice daily and euphilong taken in a single daily dose has been performed in 59 elderly patients suffering from bronchial asthma, chronic obstructive bronchitis." | 5.07 | [The comparative efficacy of the prolonged-action theophylline preparations Theopek and Euphylong in elderly patients with chronic obstructive lung diseases]. ( Belousov, IuB; Nonikov, VE; Salikova, VV, 1993) |
| "Sixteen asthmatic patients with normal diurnal activity between 05:00 and 23:00 h participated in this randomized, multiple-dose, double-blind, placebo-controlled, crossover study of the pharmacokinetics and efficacy of evening supplementation of a 12-hourly sustained-release theophylline (SRT) regimen with a nonsustained-release theophylline (NSRT) formulation." | 5.07 | Double-blind randomized cross-over trial of nocturnal elixir theophylline supplementation of a twice-daily sustained-release theophylline tablet formulation in asthmatic patients. ( du Plessis, JB; Le Roux, FP; Middle, MV; Müller, FO; Schall, R, 1993) |
| "Bronchodilator effect and toxicity of theophylline 300 mg twice a day (R1), salbutamol 4 mg tid (R2), their combination in higher (200/4mg, R3), and lower doses (100/2mg R4), and placebo (calcium lactate 300 mg) tid (R5) were compared in 25 patients with bronchial asthma in a randomized crossover trial." | 5.07 | Is combined therapy of sympathomimetics and theophylline indicated? ( Devpura, K; Garg, VK; Jain, NK; Sharma, SD; Sharma, TN, 1993) |
| "To determine the efficacy of theophylline when given in addition to nebulized albuterol and intravenously administered corticosteroid to children hospitalized with mild to moderate asthma." | 5.07 | Hospital treatment of asthma: lack of benefit from theophylline given in addition to nebulized albuterol and intravenously administered corticosteroid. ( Alpert, SE; DiGiulio, GA; Kercsmar, CM; Krug, SE; Marx, CM, 1993) |
| "To determine whether intravenously administered theophylline, when added to frequently nebulized albuterol and intravenously administered methylprednisolone, benefits children hospitalized with severe asthma." | 5.07 | Efficacy of intravenously administered theophylline in children hospitalized with severe asthma. ( Carter, E; Chesrown, S; Cruz, M; Hendeles, L; Reilly, K; Shieh, G, 1993) |
| "Theophylline, a drug used for the treatment of asthma, is recognized as an immunomodulator affecting T-lymphocytes both in vitro and in vivo." | 5.07 | Theophylline--an immunomodulatory role in asthma? ( Costello, JF; Evans, JM; McKenniff, M; Page, CP; Ward, AJ, 1993) |
| "Asthmatics treated with theophylline, a potent inhibitor of pyridoxal kinase and therefore a vitamin B6 antagonist, demonstrated a significant correlation (r = 0." | 5.07 | Theophylline increases pyridoxal kinase activity independently from vitamin B6 nutritional status. ( Becker, PJ; Delport, R; Ubbink, JB; Vermaak, WJ, 1993) |
| "The therapeutic value of a sustained-release theophylline preparation (Theospirex retard 300 mg) with administration of the daily dose once a day in the evening compared to the 2 x 1 dosage usual was investigated in 19 patients suffering from asthma symptoms manifested mainly at night." | 5.07 | [Comparison of two long-acting theophylline preparations in daily evening administration]. ( Holzer, R, 1993) |
| "Nine patients with asthma with a mean(SE) age of 65(5) years and percentage predicted forced expiratory volume in one second (FEV1 of 61(9)% participated in a double blind, placebo controlled, within subject crossover study to assess the effect of two weeks of treatment with salbutamol (Volmax; 8 mg twice daily) or theophylline (Phyllocontin; 350 mg twice daily) on lung mucociliary clearance during sleep." | 5.07 | Effect of oral bronchodilators on lung mucociliary clearance during sleep in patients with asthma. ( Agnew, JE; Clarke, SW; Hasani, A; Pavia, D; Vora, H, 1993) |
| "To compare the benefits and adverse reactions of theophylline and beclomethasone (BDP) in the long-term control of mild to moderate chronic asthma in children." | 5.07 | Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children. ( Nelson, HS; Offord, KP; Reed, CE; Tinkelman, DG, 1993) |
| "The effect of two new quinolones, ofloxacin and ciprofloxacin and nalidixic acid on serum theophylline level in 17 asthma patients treated with methylxanthines was evaluated." | 5.07 | [Effect of ofloxacin, ciprofloxacin and nalidixic acid on serum theophylline level in patients treated with methylxanthine preparations]. ( Chyrek-Borowska, S; Michalska, I; Siergiejko, Z; Szymański, W, 1992) |
| "To assess the efficacy and safety of nedocromil sodium metered dose aerosol as an adjunct to sustained-released theophylline therapy in adult theophylline-dependent asthma patients and to examine the ability of nedocromil sodium to substitute for theophylline." | 5.07 | Effects of the addition of nedocromil sodium to maintenance bronchodilator therapy in the management of chronic asthma. ( Callaghan, B; Clancy, L; Teo, NC, 1992) |
| "Ninety-six patients with nocturnal asthma (FEV1 = 60-90% pred, reversibility greater than or equal to 15%, at least 2 awakenings in the week preceding the trial) were included in a double-blind, randomized, crossover, multicenter study which compared the efficacy and side effects of inhaled salmeterol (50 micrograms morning and evening) to the association theophylline-ketotifen (300 mg and 1 mg morning and evening, respectively)." | 5.07 | [Usefulness of salmeterol in nocturnal asthma: a comparative study with theophylline-ketotifen association. A French multicenter group]. ( Georges, D; Muir, JF, 1992) |
| "The aim of this investigation was to study whether certain patients benefit from adding theophylline to the beta 2-agonist treatment of acute asthma." | 5.07 | Which patients benefit from adding theophylline to beta 2-agonist treatment in severe acute asthma? ( Boe, J; Boman, G; Janson, C, 1992) |
| ") to block or mitigate sulfur dioxide (SO2)-induced bronchoconstriction in adult subjects with asthma." | 5.07 | Theophylline mitigates the bronchoconstrictor effects of sulfur dioxide in subjects with asthma. ( Dumler, K; Koenig, JQ; Pierson, WE; Rebolledo, V; Williams, PV, 1992) |
| "Troleandomycin (TAO) is an alternative agent used in the treatment of severe, steroid-requiring asthma." | 5.07 | Effect of low-dose troleandomycin on theophylline clearance: implications for therapeutic drug monitoring. ( Brenner, AM; Hill, MR; Kamada, AK; Szefler, SJ, 1992) |
| "The subjects were 8- to 12-year-old children with asthma whose parents had observed adverse behavioral side effects while the children were taking theophylline." | 5.07 | Theophylline-induced behavior change in children. An objective evaluation of parents' perceptions. ( Bender, B; Milgrom, H, 1992) |
| "We have measured the plasma levels of salbutamol, terbutaline and theophylline in 140 patients (70 men, mean age 57 yrs) arriving for emergency treatment with severe acute asthma." | 5.07 | Bronchodilator intake and plasma levels on admission for severe acute asthma. ( Boe, J; Boman, G; Janson, C; Mossberg, B; Svedmyr, N, 1992) |
| "This study compared once-a-day dosing of Slo-bid, Theo-Dur, Theo-24 and Uniphyl, sustained release theophylline preparations, in the treatment of 12 mild to moderate asthmatic patients (FEV1 greater than 60%)." | 5.07 | Once-a-day dosing with theophylline: a comparison of four sustained-release products. ( Altman, LC; Ayars, GH; Benn, VJ; Minotti, DA; Popick, FR, 1992) |
| "Three combination regimens, (1) inhaled albuterol (ALB) with oral theophylline (THEO), (2) inhaled ALB with inhaled beclomethasone dipropionate (BDP), or (3) inhaled ALB, inhaled BDP, and oral THEO, were evaluated and compared as optimal pharmacotherapy for chronic asthma in 111 children." | 5.07 | Long-term comparison of three combinations of albuterol, theophylline, and beclomethasone in children with chronic asthma. ( Eigen, HN; Ellis, EF; Hemstreet, MP; Meltzer, EO; Orgel, HA, 1992) |
| "We conducted a study to evaluate the serum theophylline concentrations and dose interval of Theolan preparation in asthmatic children." | 5.07 | Evaluation of a once-a-day theophylline preparation in asthmatic children. ( Chang, YR; Chao, T; Hwang, B; Tang, RB; Wu, KG, 1992) |
| "Theophylline has been associated with a variety of behavioral side effects in asthmatic children." | 5.07 | Psychological change associated with theophylline treatment of asthmatic children: a 6-month study. ( Bender, BG; Comer, C; Ikle, D; Lerner, JA; Szefler, S, 1991) |
| "Salbutamol controlled-release (CR), a new salbutamol formulation, was compared in asthmatic patients to another long-acting bronchodilator, theophylline L." | 5.07 | [Delayed-release salbutamol, a new beta-mimetic with prolonged action. Results of a comparative study against theophylline L.A]. ( Brune, J; Desfougères, JL, 1991) |
| "In this study we examined the efficacy and pharmacokinetics of a new chrono-optimized theophylline sustained release preparation for once-daily dosing in the evening for treating bronchial asthma." | 5.07 | [24-hour lung function in asthmatic patients: chrono-optimal theophylline therapy as once-daily Euphylong administration vs conventional twice-daily administration]. ( D'Alonzo, GE; Emerson, MB; Feldman, S; Gianotti, LA; Sauter, R; Smolensky, MH; Staudinger, HW; Steinijans, VW, 1991) |
| "In this randomised crossover study in 26 outpatients with bronchial asthma the efficacy of a new once-daily theophylline formulation given in addition to a baseline medication was investigated; moreover, under steady state conditions, the effect of three evening intake times (6, 8 and 10 p." | 5.07 | [Efficacy of a theophylline retard preparation administered at 3 different intake times additionally to basic medication]. ( Böhm, A; Borner, K; Kunkel, G; Siebert, B; Staudinger, HW; Steinijans, VW, 1991) |
| "The effect of nifedipine on serum theophylline levels in 13 female hypertensive patients having asthma on theophylline therapy has been investigated." | 5.07 | Nifedipine alters serum theophylline levels in asthmatic patients with hypertension. ( Canberk, A; Eroğlu, L; Yilmaz, E, 1991) |
| " The effect of a new quinolone, sparfloxacin, on the pharmacokinetics and metabolism of theophylline was investigated in six asthmatic patients receiving chronic theophylline therapy (a sustained-release theophylline tablet formulation of 200 to 300 mg twice daily at 12-h intervals)." | 5.07 | Effect of a new quinolone, sparfloxacin, on the pharmacokinetics of theophylline in asthmatic patients. ( Hasegawa, T; Kuzuya, T; Nadai, M; Takagi, K; Yamaki, K, 1991) |
| "Patients with moderate to severe asthma, from two urban general practices, entered a double-blind randomised placebo-controlled crossover trial of sustained-release theophylline versus placebo." | 5.07 | A double-blind placebo-controlled trial of theophylline in general practice. ( Crombie, IK; McDevitt, DG; Neville, RG, 1991) |
| "In a multicentre, randomized, cross-over double-blind, double placebo trial the effectiveness and tolerability of slow-release oral salbutamol (SRS) were compared with those of long-acting (LA) theophylline (T) in the treatment of nocturnal asthma of adults." | 5.07 | [Slow-release salbutamol in the treatment of nocturnal asthma. Result of a comparative study vs. long-acting theophylline]. ( Arnaud, A; Desfougères, JL; Michel, FB; Pappo, M, 1991) |
| "The effect of theophylline and cromolyn sodium on sleep was studied in 10 children with asthma who were 10 to 17 years of age (mean 13." | 5.07 | Sleep quality in children with asthma treated with theophylline or cromolyn sodium. ( Avital, A; Chernick, V; Kryger, M; Pasterkamp, H; Sanchez, I; Steljes, DG, 1991) |
| "To determine whether oral slow-release theophylline inhibits asthmatic reactions and the associated increase of airway responsiveness to methacholine induced by allergens, we examined six asthmatic subjects who developed a dual asthmatic reactions after allergen bronchoprovocation with Dermatophagoides pteronyssinus or with grass pollen." | 5.07 | Theophylline inhibits early and late asthmatic reactions induced by allergens in asthmatic subjects. ( Boschetto, P; Crescioli, S; Fabbri, LM; Mapp, CE; Plebani, M; Pozzani, M; Spinazzi, A, 1991) |
| "The aim of this study was to compare the effects upon gastric secretion of therapeutic doses of aminophylline, with doxofylline, a new xanthine derivative proposed for the treatment of chronic asthma." | 5.06 | The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients. ( Bianchi Porro, G; Grossi, E; Lazzaroni, M, 1990) |
| "A double-blind, randomized, crossover chronic study was done to determine the efficacy of colchicine in 10 atopic patients with asthma." | 5.06 | A clinical and immunologic study of colchicine in asthma. ( Garty, MS; Greif, J; Ilfeld, DN; Kivity, S; Schlesinger, M; Schwarz, YA; Topilsky, M, 1990) |
| "To determine the efficacy of nedocromil sodium in adult asthma patients using bronchodilators alone to control their disease, a consecutive sample of 127 patients with long-term asthma was studied for 16 weeks." | 5.06 | A double-blind multicenter group comparative study of the efficacy and safety of nedocromil sodium in the management of asthma. North American Tilade Study Group. ( , 1990) |
| "In this randomized crossover study of 26 outpatients with bronchial asthma the efficacy of a new once-daily theophylline formulation given in addition to a baseline medication was investigated; moreover, under steady state conditions, the effect of three evening intake times (6, 8 and 10 p." | 5.06 | Efficacy of sustained release theophylline given at three different evening intake times in addition to a baseline medication. ( Borner, K; Kunkel, G; Siebert, B; Staudinger, HW; Steinijans, VW, 1990) |
| "Nine adult asthmatics with a history of nocturnal symptoms and with morning dips in peak expiratory flow (PEF) were treated for 10-14 days with 24-h controlled-release preparation of theophylline (Th), or a controlled-release preparation of terbutaline (Te), in a double-blind cross-over experiment." | 5.06 | Nocturnal oxygen saturation and body movement in asthmatics treated with controlled-release preparations of theophylline or terbutaline. ( Brander, PE; Hakulinen, A; Poppius, H; Salmi, T; Sovijärvi, AR, 1990) |
| "Enprofylline, a drug without adenosine antagonism and theophylline, a potent adenosine antagonist, were compared, double-blind, randomized, in acute asthma (n = 33)." | 5.06 | Comparison between theophylline and an adenosine non-blocking xanthine in acute asthma. ( Amundsen, T; Brenna, E; Eriksson, G; Holte, S; Källén, AG; Naustdal, T; Persson, CG; Storstein, L; Syvertsen, U; Vilsvik, JS, 1990) |
| "Twenty-four patients (five women) aged 53-72 yr with both ischemic heart disease and asthma or chronic bronchitis receiving oral beta 2-agonists also received additional bronchodilating therapy with theophylline (600 mg daily), enprofylline (600 mg daily) or placebo." | 5.06 | Arrhythmogenicity from combined bronchodilator therapy in patients with obstructive lung disease and concomitant ischemic heart disease. ( Conradson, TB; Eklundh, G; Olofsson, B; Pahlm, O; Persson, G, 1987) |
| "5 mg of reproterol hydrochloride (Aarane) administered by metered dose inhaler through 4 different spacer devices (Volumatic, Nebuhaler, InspirEase and Synchron-Aerosol) was tested in 18 asthmatic patients (age 8-15 years)." | 5.06 | [Effectiveness of various inhalation aids in children with bronchial asthma]. ( Robinson, S; Schöni, MH, 1989) |
| "The clinical effectiveness and the pharmacokinetic parameters of a once-a-day sustained release preparation of anhydrous theophylline were studied in a trial carried out on 10 adult patients affected by bronchial asthma or chronic obstructive lung disease." | 5.06 | [Clinico-laboratory evaluation a new sustained-release preparation of anhydrous theophylline]. ( Aiolfi, S; Capellini, G; Gandola, L; Ghio, L; Mauri, F; Patrini, G; Scartabellati, A; Soccini, F, 1989) |
| "131 asthmatics aged 12-65 years, who still had symptoms despite inhaled or oral bronchodilators, were included in this double-blind group comparative study involving nedocromil sodium (2 puffs of 2 mg each twice daily) and placebo (2 puffs twice daily)." | 5.06 | [Nedocromil sodium therapy in asthma patients. Therapeutic effect in addition to treatment with oral theophylline and inhaled bronchodilator agents]. ( Beck, W; Boos, R; van Kampen, C; Weede, W, 1989) |
| "Percentage reductions in the peak flow rates to a standardized number of histamine inhalations were compared after 7 days of treatment with 10 mg bd tazifylline and after 7 days of placebo in a randomized crossover study in 11 male seasonal atopic asthmatics." | 5.06 | The reducing effects of tazifylline on histamine-induced bronchoconstriction in atopic asthmatics. ( Harlow, B; Kiviranta, K; Reuter, C; Scott, J; Stenius-Aarniala, B, 1989) |
| "We tested an aminophylline loading-dose protocol in which asthmatic patients presenting to an emergency department were given a half (3 mg/kg) IV loading dose based on total body weight (TBW) if they had taken a short-acting or sustained-release theophylline preparation within 12 or 24 hours, respectively, prior to arrival: otherwise, a full (6 mg/kg) loading dose was administered." | 5.06 | Aminophylline loading in asthmatic patients: a protocol trial. ( Marcus, RH; Parvin, CA; Stine, RJ, 1989) |
| "To evaluate the long-term effects of slow-release formulations of theophylline and terbutaline on pulmonary function, clinical symptoms, and side effects, 24 children with stable and moderately severe perennial asthma participated in a prospective double-blind cross-over study." | 5.06 | Slow-release terbutaline and theophylline for the long-term therapy of children with asthma: a Latin square and factorial study of drug effects and interactions. ( Chow, OK; Fung, KP, 1989) |
| "It has been suggested that theophylline may possess anti-inflammatory actions which underlie its antiasthma properties." | 5.06 | Effect of theophylline on airway responses to inhaled platelet-activating factor in man. ( Barnes, PJ; Chung, KF; Lammers, JW; McCusker, M; Nichol, GM; Roberts, NM, 1989) |
| "The effect of increasing intravenous doses of theophylline and enprofylline, a new xanthine derivative, on bronchial responsiveness to methacholine was studied in eight asthmatic patients." | 5.06 | Effect of theophylline and enprofylline on bronchial hyperresponsiveness. ( Boorsma, M; Jonkman, JH; Koëter, GH; Kraan, J; van der Mark, TW, 1989) |
| "Potential day-night differences of theophylline absorption and disposition were examined in day-active asthmatic children." | 5.06 | Day-night differences in steady-state theophylline pharmacokinetics in asthmatic children. ( Baenziger, JC; Eigen, H; Harrist, RB; Hiatt, PW; Klank, BJ; Kramer, WG; Scott, PH; Smolensky, MH, 1989) |
| "Fifteen otherwise healthy asthmatics with reversible airway obstruction were treated with salbutamol (8 mg slow release twice daily) and theophylline (300 mg twice daily)." | 5.06 | Effect of theophylline and salbutamol on hepatic drug metabolism. ( Christensen, HR; Døssing, M; Evald, T; Lange, P, 1989) |
| "In a group of ten patients with chronic asthmatic bronchitis, the effect of monotherapy with theophylline and terbutaline and the combination of both drugs, as sustained-release tablets, was compared to placebo, in a double-blind cross-over, triple dummy at random study." | 5.06 | Combination therapy of theophylline and terbutaline as sustained-release preparations in patients with asthmatic bronchitis. ( Fokkens, JK; Hamelink, MJ; Kreukniet, J; Maes, RA; van der Vet, AP; van Drost, RH, 1987) |
| "We studied 15 nonsmoking, clinically stable asthmatic subjects aged 27 to 39 years to evaluate the potential cardiotoxic effects of combined use of a beta-adrenergic agonist drug and theophylline in the treatment of asthma." | 5.06 | Cardiac arrhythmias during the combined use of beta-adrenergic agonist drugs and theophylline. ( Barker, AF; Buist, AS; Coleman, JJ; Schultz, GE; Vollmer, WM, 1986) |
| "Forty patients suffering from asthmatic conditions, often accompanied by emphysema, were treated either with an extempore combination of salbutamol syrup plus 30-mg oxatomide tablets or with 30-mg oxatomide tablets alone for purposes of comparison." | 5.06 | Treatment of asthma with an extempore combination of a bronchodilator, salbutamol, and a new antihistamine drug, oxatomide. ( Caprioglio, L; Scremin, S, 1986) |
| "Chronic nonsteroid-dependent childhood asthma was treated by adding beclomethasone dipropionate (BDP) or placebo (P) to the daily regimen of theophylline (T)." | 5.06 | Twice-daily beclomethasone dipropionate in the treatment of childhood asthma. ( Katz, RM; Rachelefsky, GS; Rohr, AS; Siegel, SC; Spector, SL, 1986) |
| "The effect of long-term treatment with theophylline was studied in 20 chronic asthmatic patients receiving oral and inhaled beta 2-agonists." | 5.06 | Theophylline in maintenance treatment of chronic asthma: concentration-dependent additional effect to beta 2-agonist therapy. ( Billing, B; Dahlqvist, R; Hörnblad, Y; Leideman, T; Ripe, E; Skareke, L, 1987) |
| "This study examined the potential side effects of theophylline on behavior, attention, memory, and fine motor function in children with asthma." | 5.06 | Effects of theophylline on behavior and learning in children with asthma. ( Coffman, H; DeGraw, C; Fenton, T; Guare, R; Rappaport, L; Twarog, F, 1989) |
| "The effects on bronchoconstriction, on non-specific bronchial hyperreactivity (nBH), and the pharmacokinetics at steady state of two theophylline preparations, controlled release (CR) capsules (Riker Pharmaceuticals) and UnixanR tablets (Pharmacia) were compared in patients with nocturnal asthma." | 5.06 | Comparison between steady state pharmacokinetics and effects of two once-daily, slow-release theophylline formulations in nocturnal asthma. ( Almind, M; Frølund, L; Madsen, F; Nielsen, NH; Svendsen, UG; Weeke, B, 1988) |
| "After one week theophylline therapy with a sustained release preparation (TheoDur 200 and 300 mg), a mean theophylline level of 10 mg/l was obtained in a group of ten patients with chronic asthmatic bronchitis with a mean dosage of 760 mg theophylline/24 h." | 5.06 | Lung function improvement, tremor measurements and c-AMP determinations in a group of ten patients with asthmatic bronchitis after one week sustained release theophylline medication (theophylline plasma level +/- 10 mg/l) compared to one week placebo. ( Drost, RH; Fokkens, JK; Hamelink, ML; Kreukniet, J; Maes, RA; Van der Vet, AP, 1986) |
| "Ninety-six patients with reversible airways disease and a history of nocturnal asthma completed a four-week open-label study that compared the effectiveness of Uniphyl tablets (The Purdue Frederick Company, Norwalk, Connecticut) administered once daily in the morning or the evening with twice-daily baseline theophylline therapy." | 5.06 | Multicenter comparison of once-daily Uniphyl tablets administered in the morning or evening with baseline twice-daily theophylline therapy in patients with nocturnal asthma. ( Grossman, J, 1988) |
| "Twenty-one patients, 12 to 18 years of age, with nocturnal asthma controlled with sustained-release theophylline administered twice daily, were enrolled in a 10-week, double-blind, two-way crossover study that compared Theo-Dur tablets administered twice daily with an equivalent daily dose of Uniphyl tablets administered once daily at bedtime." | 5.06 | Is a uniform round-the-clock theophylline blood level necessary for optimal asthma therapy in the adolescent patient? ( Bierman, CW; Furukawa, CT; Pierson, WE; Shapiro, GG, 1988) |
| "In view of the lack of published data on the oral bronchodilator preparation 'Franol' (120 mg theophylline, 11 mg ephedrine hydrochloride and 8 mg phenobarbitone per tablet) a double-blind study was carried out to compare the effects on lung function of a single dose of 2 'Franol' tablets, 1 'Franol' plus 1 placebo tablet, or 2 placebo tablets over a period of 8 hours in 30 asthmatic patients with reversible airways resistance (mean FEV1 1." | 5.06 | A controlled trial of an oral bronchodilator preparation ('Franol') in asthma. ( Campbell, L; Owen, S; Stone, P; Webster, S; Woodstock, AA, 1988) |
| "Forty adult patients with chronic asthma completed a 3-month double-blind crossover study to compare the effect of sustained-release theophylline given both as a fixed 300 mg twice daily dose (standard) and an individually titrated dose (titrated) with placebo." | 5.06 | A double-blind, placebo-controlled comparison of the efficacy of standard and individually titrated doses of theophylline in patients with chronic asthma. ( Barlow, TJ; Graham, P; Harris, JM; Hartley, JP; Turton, CW, 1988) |
| "The effects of a new inhaled antimuscarinic drug, oxitropium bromide, and of a slow-release theophylline preparation upon nocturnal asthma were compared in a placebo-controlled double-blind study." | 5.06 | Comparison of the effect of oxitropium bromide and of slow-release theophylline on nocturnal asthma. ( Bellia, V; Cibella, F; Cuttitta, G; Ferrara, G; Insalaco, G; Mirto, M; Peralta, G; Visconti, A, 1988) |
| "Sixteen patients were included in the analysis of this double-blind crossover study comparing the effect of sodium cromoglycate, reproterol, sodium cromoglycate plus reproterol, and placebo in exercise-induced asthma." | 5.06 | Double-blind crossover study comparing sodium cromoglycate, reproterol, reproterol plus sodium cromoglycate, and placebo in exercise-induced asthma. ( Debelić, M; Hertel, G; König, J, 1988) |
| "The aim of this study was to evaluate the effect of a sustained-release theophylline preparation on bronchial responsiveness to cold dry air inhalation in asthmatic subjects." | 5.06 | Theophylline minimally inhibits bronchoconstriction induced by dry cold air inhalation in asthmatic subjects. ( Cartier, A; Ghezzo, H; L'Archevêque, J; Malo, JL; Merland, N, 1988) |
| "Theophylline retard "Oranienburg" has been applied in mild and intermediate forms of bronchial asthma as monotherapy (n = 40), and in severe forms of the disease in combination with other antiasthmatics (n = 21)." | 5.06 | [Clinical use of theophylline retard Oranienburg]. ( Förster, R; Hummel, S; Meister, W; Nussbücker, B; Rentsch, E; Slapke, J; Wenz, W; Wiesner, B; Wilke, A, 1988) |
| "Two theophylline treatments were compared in a randomized, multiple-dose, crossover study on 20 patients present with nonallergic bronchial asthma." | 5.06 | Therapeutic advantage of unequal dosing of theophylline in patients with nocturnal asthma. ( Dorow, P; Steinijans, VW, 1987) |
| "Twenty school children with chronic asthma who despite regular prophylactic therapy continued to have troublesome nocturnal wheeze or cough entered a double-blind cross-over study in which a once daily theophylline preparation was compared with placebo to assess control of these symptoms." | 5.06 | A once daily theophylline preparation in prevention of nocturnal symptoms in childhood asthma. ( Bose, B; Cater, JI; Clark, RA, 1987) |
| "The effect of adding slow release nifedipine to oral theophylline has been studied in eight patients with stable but symptomatic asthma, a double blind placebo controlled crossover protocol being used." | 5.06 | Effect of nifedipine on serum theophylline concentrations and asthma control. ( Kendall, MJ; Skinner, C; Smith, SR; Stableforth, DE; Wiggins, J, 1987) |
| "Sixteen patients with asthma and/or chronic obstructive lung disease were treated for 8 days by scored tablets of sustained-release theophylline." | 5.06 | [Prescription of Theostat 300 as a single evening dose]. ( Bida, C; Germouty, J; Moreau, L, 1987) |
| "We studied the relationship between attenuation of exercise-induced bronchoconstriction and serum theophylline concentration in a dose-dependent fashion in 11 patients with mild bronchial asthma." | 5.06 | Methylxanthines inhibit exercise-induced bronchoconstriction at low serum theophylline concentration and in a dose-dependent fashion. ( Jörres, R; Magnussen, H; Reuss, G, 1988) |
| "In order to assess whether clinically important changes in serum theophylline concentrations occur when patients switch their brand of slow-release (SR) theophylline, 10 subjects with asthma were administered the same dose of four different SR theophylline formulations for 2-week periods in a random, double-blinded, crossover manner." | 5.06 | Clinical relevance of the substitution of different brands of sustained-release theophylline. ( Baker, JR; DeNapoli, T; Gonzalez, U; Grabenstein, J; Moessner, H; Renard, R; Schuster, B; Summers, R, 1988) |
| "Concern about side-effects of theophylline prompted us to investigate whether this drug could be eliminated from the multi-medication regimen of severe asthmatics." | 5.06 | Need for theophylline in severe steroid-requiring asthmatics. ( Berkowitz, R; Brenner, M; Marshall, N; Strunk, RC, 1988) |
| "This study was performed in a randomized double-blind manner on 6 separate days in 10 asthmatic patients to investigate the effect of a sustained theophylline on baseline bronchial hyperreactivity to histamine in relation to the theophylline serum levels and the degree of bronchodilatation produced." | 5.06 | Relationship of serum theophylline concentrations to histamine-induced bronchospasm. ( Ciccarello, C; Crimi, N; Distefano, SM; Mistretta, A; Oliveri, R; Palermo, B; Palermo, F; Vancheri, C, 1987) |
| "A new sustained-release theophylline preparation has been designed with the purpose of providing 24-hour protection against bronchospasm in asthmatics when given as a single dose." | 5.06 | Once daily theophylline in childhood asthma. ( Levene, S; McKenzie, S, 1986) |
| "Because there are few published studies on capsulized sustained-release theophylline (SRT) products in children, we compared Slo-bid capsules to Theo-Dur tablets in a group of school age children and young adults with asthma in an 8-week randomized crossover study design with patients maintaining daily symptom diary cards and peak expiratory flow rates." | 5.06 | Comparison study of sustained-release theophylline products: Slo-bid capsules versus Theo-Dur tablets in 20 children and young adults with asthma. ( Hannaway, PJ; Hopper, GD, 1986) |
| "In a four-week study, 20 children with chronic asthma were treated in a randomized, double-blind, crossover manner with two sustained-release theophylline preparations (Theo-Dur and Uniphyl) to compare their drug concentrations and clinical efficacy." | 5.06 | Sustained-release theophylline preparations in asthmatic children. A short-term comparison of two products and the relationship of serum theophylline levels and pulmonary function changes. ( Gracey, V; Katz, R; Mickey, MR; Rachelefsky, G; Rohr, A; Siegel, S; Spector, S; Wo, J, 1986) |
| "Thirty-nine patients with asthma requiring acute treatment were included in a randomized, double-blind, parallel study which compared the effect of enprofylline (1." | 5.06 | Comparison of enprofylline and theophylline for intravenous treatment of acute asthma. ( Eriksson, G; Haahtela, T; Venho, K, 1986) |
| "The bronchial responsiveness of a group of asthmatic children was studied using histamine stimulation after a single dose of theophylline and after placebo." | 5.06 | Protective effect of theophylline on histamine-induced bronchoconstriction in asthmatic children. ( Levene, S; McKenzie, SA, 1986) |
| "Fifteen asthmatic outpatients were randomly treated during two periods of 14 days each with sustained-release preparations of either enprofylline (3-propyl-xanthine) or theophylline (Theo-Dur) in a double-blind crossover study." | 5.06 | Enprofylline and theophylline slow-eroding tablets in the treatment of asthma: a comparison. ( Eriksson, G; Laursen, LC; Weeke, B, 1986) |
| "The efficacy and side effects of oral or inhaled terbutaline were examined in 13 mild-to-moderate asthmatic patients (ages 12 to 71 years) on maintenance theophylline (levels 10 to 25 micrograms/ml)." | 5.06 | Addition of terbutaline to optimal theophylline therapy. Double blind crossover study in asthmatic patients. ( Kray, KT; Nelson, HS; Vandewalker, ML; Weber, RW, 1986) |
| "Two slow-release preparations of theophylline have been compared in an open crossover trial in the treatment of 20 asthmatic children." | 5.06 | Comparison of two new controlled-release theophylline formulations in the management of asthma in children and reliability of salivary theophylline concentration. ( Bennati, D; Boner, AL; Gaburro, D; Miglioranzi, P, 1986) |
| "To compare the acute bronchodilator effect of increasing doses of intravenous theophylline and inhaled beta adrenergic agonists, we administered intravenous theophylline dissolved in ethylenediamine or proxyphylline and diprophylline or placebo in a double blind fashion to nine asthmatics on three different days." | 5.06 | Bronchodilator effect of theophylline preparations and aerosol fenoterol in stable asthma. ( Hartmann, V; Jörres, R; Magnussen, H, 1986) |
| "The therapeutic effects of either morning or evening administration of a once-daily controlled release theophylline preparation (Uniphyllin) were studied in 17 asthmatic children." | 5.06 | Once a day theophylline in chronic childhood asthma? ( Davies, H; Helms, P; Leakey, T; Stroobant, J, 1986) |
| "A double blind crossover trial with active or placebo slow release theophylline (Slo-phyllin) in children with asthma aged up to 4 years is described." | 5.06 | Slow release theophylline in preschool asthmatics. ( Conway, SP; Houlsby, WT, 1986) |
| "The extrapulmonary effects of slow-release theophylline and an inhaled beta 2-agonist (albuterol) were examined separately and in combination among 18 adults and adolescents with asthma during a 3-month randomized, double-blind, crossover trial." | 5.06 | Extrapulmonary effects of maintenance therapy with theophylline and inhaled albuterol in patients with chronic asthma. ( Ahrens, RC; Joad, JP; Lindgren, SD; Weinberger, MM, 1986) |
| "Sustained release theophylline products can improve compliance and symptom control in children with asthma." | 5.06 | Apparent inconsistent theophylline absorption from sustained release capsules. ( Schaber, DE; Uden, DL; Wyatt, RA, 1987) |
| "Five different doses of enprofylline, a 3-propylxanthine, were compared with a standard dose of theophylline in 135 episodes of acute asthma in a double-blind study." | 5.06 | Efficacy of enprofylline, a new bronchodilating xanthine, in acute asthma. ( Boe, J; Eriksson, G; Ljungholm, K, 1987) |
| "Theophylline level variability obtained with standard slow-release theophylline tablets was compared to that obtained with a new sustained-release theophylline suspension in asthmatic children." | 5.06 | A new sustained-release theophylline suspension for asthmatic children: evaluation of serum theophylline concentrations. ( Bernocchi, D; Boner, AL; Plebani, M; Valletta, E; Vallone, G, 1987) |
| "Serum theophylline levels produced by two bands of sustained-release theophylline tablets, TheoDur and Respbid, were compared in a double-blind crossover study in 13 asthmatic children." | 5.06 | Serum drug fluctuations after administration of two sustained-release oral theophylline preparations in asthmatic children. ( Logvinoff, MM; Seifert, B; Watts, MT; Weinstein, DB, 1986) |
| " for 2 weeks, was studied in a randomized, double-blind, crossover trial in nine patients with asthma receiving theophylline." | 5.06 | Effect of nifedipine and theophylline in asthma. ( Cohen, E; Garty, M; Ilfeld, DN; Mazar, A; Rosenfeld, JB; Spitzer, S, 1986) |
| "The pharmacokinetics of two slow release theophylline preparations "Theo-Dur" (T) containing theophylline only and "Phyllocontin" (P) containing aminophylline have been compared in 12 patients with asthma." | 5.06 | Methods of comparing pharmacokinetics of slow release preparations: a comparison of "Theo-Dur" and "Phyllocontin" in patients with asthma. ( Jackson, SH; Shah, K; Turner, P, 1986) |
| "The goal of the current study was to determine whether administration of a methylxanthine preparation in the form of a retention enema (theophylline-diprophylline-proxyphylline combination, Neobiphyllin-Clys) has an effect similar to that of intravenous theophylline in the treatment of acute bronchospasm." | 5.06 | Effect of a methylxanthine preparation in the form of a retention enema on pulmonary function and theophylline levels in patients with acute bronchospasm. ( Dorow, P; Dougherty, C; Schenk, H, 1986) |
| "Sustained-release, 24-hour theophylline preparations have been formulated and may provide for convenient once-a-day dosing, although the use of such products in clinical asthma has yet to be fully established." | 5.06 | The use of a single daily theophylline dose and metered-dose albuterol in asthma treatment. ( Bush, RK; Busse, WW; Smith, A, 1986) |
| "The effect on bronchial smooth muscle of slow release theophylline plus placebo and theophylline plus slow release nifedipine administered for a prolonged period to 12 asthmatic and hypertensive patients has been studied." | 5.06 | Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma. ( Lombardi, C; Spedini, C, 1986) |
| "Studies evaluating adverse effects of oral theophylline on learning and behavior have been performed on children with asthma receiving long-term theophylline therapy." | 5.06 | Behavior abnormalities and poor school performance due to oral theophylline use. ( Adelson, J; Katz, RM; Mickey, MR; Rachelefsky, GS; Rohr, AS; Siegel, SC; Spector, SL; Wo, J, 1986) |
| "The relative benefit of maintenance therapy with theophylline, inhaled albuterol, and the combination was examined in 18 adolescents and adults with chronic asthma during a 3-month, randomized, double-blind, crossover trial." | 5.06 | Relative efficacy of maintenance therapy with theophylline, inhaled albuterol, and the combination for chronic asthma. ( Ahrens, RC; Joad, JP; Lindgren, SD; Weinberger, MM, 1987) |
| "In study I, carried out on 9 asthmatics to investigate whether the bronchodilator and protective effect of intravenous theophylline, dissolved in ethylene diamine (T." | 5.06 | [Comparison of the bronchodilator and protective effect of methylxanthines]. ( Jörres, R; Litt, M; Magnussen, H; Reuss, G; Stutz, P, 1986) |
| "We investigated the intensity and duration of the effect of a single dose of slow-release theophylline on bronchial hyperresponsiveness to ultrasonically nebulized distilled water in asthma." | 5.06 | Long-lasting protective effect of slow-release theophylline on asthma induced by ultrasonically nebulized distilled water. ( Alessandri, MV; De Marzo, N; Fabbri, LM; Mapp, CE; Paleari, D; Pozzan, M; Zocca, E, 1986) |
| "Sixty-one chronic asthmatic children received either a new slow-release sprinkle format of theophylline, twice daily, or theophylline liquid, 4-times per day." | 5.06 | A comparative study of theophylline in a slow-release 'sprinkle' format with a standard syrup preparation in young children with asthma. ( Dawson, KP, 1986) |
| "Theophylline is still one of the most widely prescribed drugs for the treatment of asthma and COPD in developing countries because the majority of asthma and COPD medicines are largely unavailable and also because it is a cheap option." | 5.05 | The effect of doxofylline in asthma and COPD. ( Cazzola, M; Matera, MG, 2020) |
| "A randomized multicentre trial was done to investigate the protective effects of ketotifen and disodium cromoglycate (DSCG) in the therapy of bronchial asthma." | 5.05 | [Treatment of seasonal asthmatic symptoms. A multicentre trial to compare the effects of ketotifen and disodium cromoglycate (author's transl)]. ( Borelli, S; Düngemann, H; Schiess, W, 1980) |
| "Twelve asthmatic patients with nocturnal wheezing were given a single nocturnal oral dose of slow-release aminophylline or matched placebo in a double-blind crossover trial." | 5.05 | Single-dose slow-release aminophylline at night prevents nocturnal asthma. ( Barnes, PJ; Greening, AP; Neville, L; Poole, GW; Timmers, J, 1982) |
| "The influence of pretreatment with equipment bronchodilating doses of intravenous theophyllamine and inhaled terbutaline on the effect of five terbutaline inhalations was investigated in a cross-over study in six adult asthmatics with stable and reproducible bronchoconstriction." | 5.05 | Does theophylline potentiate inhaled beta 2-agonists? ( Svedmyr, K; Svedmyr, N, 1982) |
| "5 mg) combined with 280 mg anhydrous theophylline orally in the randomized, double-blind, cross-over study in eight asthmatics." | 5.05 | Effects of oral theophylline combined with oral and inhaled beta-2-adrenostimulants in asthmatics. ( Svedmyr, K, 1982) |
| "The therapeutic value of adding a slow-release theophylline product (Theo-Dur) to the regular treatment program consisting of beta-stimulants and steroids was evaluated in 31 adult asthmatics." | 5.05 | Combined theophylline/beta-agonists maintenance therapy in chronic asthma. ( Eriksson, NE; Ewald, U; Haglind, K, 1983) |
| "In two groups of patients, 15 with asthma and 15 with chronic bronchitis, the bronchodilator effects of ipratropium bromide, of fenoterol plus theophylline, and of the combination of the three drugs, were compared using a double-blind, single-dose, placebo-controlled format." | 5.05 | The addition of an aerosol anticholinergic to an oral beta agonist plus theophylline in asthma and bronchitis. A double-blind single dose study. ( Baskerville, J; Blennerhassett, G; Lefcoe, NM; Paterson, NA; Toogood, JH, 1982) |
| "The role of the anticholinergic drug, ipratropium bromide, in maintenance antiasthmatic therapy was evaluated in a double-blind crossover trial of three bronchodilator regimens: (1) inhaled ipratropium, placebo, and oral oxtriphylline; (2) inhaled fenoterol, placebo, and oral oxtriphylline; and (3) both inhaled ipratropium and fenoterol plus oral oxtriphylline." | 5.05 | Anticholinergic and sympathomimetic combination therapy of asthma. ( Chapman, KR; Gent, M; Rebuck, AS, 1983) |
| "Ipratropium (40 micrograms) and theophylline (oxtriphylline 400 mg) were administered to 24 asthmatics in a randomized double-blind placebo controlled trial." | 5.05 | Combined therapy with ipratropium and theophylline in asthma. ( Cohen, C; Frank, H; Ghezzo, H; Kreisman, H; Vickerson, F; Wolkove, N, 1984) |
| "The protective effects of oxyphenonium bromide, terbutaline and theophylline were compared in 8 asthmatic patients by determination of the degree of non-specific airway reactivity after 1 week of oral treatment according to a fixed dose scheme in a double-blind random order: oxyphenonium bromide 3 X 10 mg; terbutaline 3 X 5 mg; theophylline 2 X 300 mg and placebo." | 5.05 | Protective effect of oral oxyphenonium bromide, terbutaline and theophylline against the bronchial obstructive effects of inhaled histamine, acetylcholine and propranolol. ( de Vries, K; de Zeeuw, RA; Greving, J; Jonkman, JH; Koëter, GH; Leferink, J; Meurs, H; Sluiter, HJ, 1984) |
| "In 6 asthmatic patients, the possibility of obtaining a steady state plasma level of 5 mg/l of enprofylline by administration of two constant rate infusions was examined." | 5.05 | Intravenous administration of enprofylline to asthmatic patients. ( Fagerström, PO; Johannesson, N; Laursen, LC; Weeke, B, 1983) |
| "Fifty clinically stable patients with asthma on maintenance theophylline therapy, mean dose of 15 mg kg-1 per day, were switched to an equivalent dose (X 1." | 5.05 | Study of oxtriphylline SA in 50 asthmatics. ( Bukantz, SC; Fox, RW; Lockey, RF; Samaan, SS, 1983) |
| "A double blind crossover comparison of slow-release theophylline, ketotifen and placebo was carried out in 18 young children with perennial asthma." | 5.05 | A controlled comparison of slow-release theophylline, ketotifen and placebo in the prophylaxis of asthma in young children. ( Carswell, F; Fysh, WJ; Hughes, AO; Robinson, P; Stratton, D, 1983) |
| "A double-blind randomized study of 50 patients was conducted to evaluate the efficacy and safety of terbutaline sulfate aerosol and isoproterenol sulfate aerosol in the treatment of patients with moderate to severe asthma." | 5.05 | Terbutaline sulfate and isoproterenol sulfate (metered dose aerosols) in the treatment of asthma. ( Kemp, JP; Meltzer, EO; Orgel, HA; Welch, MJ, 1983) |
| "In a co-operative study involving 10 centres, 95 asthmatic patients were treated with Armophylline, a new slow-release theophylline for a period of 1 to 3 months." | 5.05 | [Multicenter study of a slow-release theophylline: armophylline]. ( Akoun, G; Battesti, JP; Bignon, J; Caubarrere, I; Charpin, J; Chicou, JF; Godard, P; Herman, DM; Julien, D; Michel, FB, 1983) |
| "Clinical trials of slow-release theophylline and ketotifen as prophylaxis against asthma in 18 young children suggested that both drugs had some efficacy." | 5.05 | Double-blind comparisons of slow-release theophylline, ketotifen and placebo for prophylaxis of asthma in young children. ( Carswell, F; Fysh, WJ; Hughes, AO; Robinson, P; Stratton, D, 1984) |
| "The effects of a therapeutic serum theophylline concentration on inhaled methacholine and histamine were studied in 8 stable, moderately severe asthmatic children 8 to 15 yr of age." | 5.05 | Effects of theophylline on inhaled methacholine and histamine in asthmatic children. ( Howick, J; Kelly, HW; McWilliams, BC; Menendez, R, 1984) |
| "Twenty-five asthmatic outpatients were treated for 3 one-week periods with either enprofylline slowly eroding 300 mg tablets t." | 5.05 | Continuous treatment of asthmatic patients with enprofylline and theophylline. ( Johannesson, N; Laursen, LC; Weeke, B, 1984) |
| "Verofylline, a long-acting polysubstituted methylxanthine bronchodilator, was taken orally by eight adult patients with asthma in a double-blind, crossover tolerance study." | 5.05 | Verofylline, a methylxanthine bronchodilator, in asthma. ( Booker, WM; Lucas, SG; Malveaux, FJ; Morris, EA; Pittman, J; Rachal, RE; Young, RC, 1984) |
| "Two controlled-release theophylline drugs, T-D (Theo-Dur tablets) administered 12-hourly, and preparation U (Uniphyl tablets) once daily, given in 7-day sequences in daily 800-mg doses, produced comparable steady-state serum profiles in nonsmoking adults with asthma, chronic bronchitis, or both, showing acceptable theophylline clearances." | 5.05 | Serum profile and bioavailability of a controlled-release theophylline formulation for once-daily use: comparison with a 12-hr preparation. ( Cohen, BM, 1984) |
| "Twice daily sustained release theophylline gave satisfactory steady serum theophylline concentrations in asthmatic children aged 7 to 14 years." | 5.05 | Sustained release theophylline in nocturnal asthma. ( Barnes, ND; Elias-Jones, AC; Godden, DJ; Higenbottam, TW, 1984) |
| "The effectiveness of cromolyn sodium and theophylline on asthma in children was compared during a 3-month trial." | 5.05 | A double-blind study comparing the effectiveness of cromolyn sodium and sustained-release theophylline in childhood asthma. ( Bierman, CW; Furukawa, CT; Kraemer, MJ; Pierson, WE; Shapiro, GG; Ward, DJ, 1984) |
| "The bioavailability and absorption pattern of theophylline from a slow-release theophylline sprinkle preparation were investigated in 12 asthmatic children both in fasting conditions and after a standardized meal." | 5.05 | Erratic absorption of a slow-release theophylline sprinkle product. ( Møller-Petersen, J; Pedersen, S, 1984) |
| "The bronchodilator effect and side-effects of a single oral dose of enprofylline were compared with the corresponding actions of a therapeutic dose of theophylline in 20 asthmatic patients, in a randomized cross-over clinical trial." | 5.05 | Comparison of oral enprofylline and theophylline in asthmatic patients. ( Johannesson, N; Laursen, LC; Søndergaard, I; Weeke, B, 1984) |
| "This study was a randomized double-blind evaluation of three doses of dyphylline, theophylline, and placebo for blocking exercise-induced bronchospasm (EIB)." | 5.05 | Dyphylline versus theophylline: a double-blind comparative evaluation. ( Bierman, CW; Furukawa, CT; Pierson, WE; Shapiro, GG, 1983) |
| "After one year of sustained-release theophylline (SRT) treatment, 19 children with severe perennial asthma participated in a 6-week, placebo-controlled, randomized, double-blind cross-over study." | 5.05 | Long-term treatment of children with sustained-release theophylline. ( Nathan, E; Pedersen, S, 1983) |
| "In a double-blind, cross-over trial comprising 19 adult asthmatic patients a sustained-release preparation of theophylline (Theo-Dur), given twice daily, was compared with a conventional fast-release preparation (Nuelin), given three times daily." | 5.05 | Comparison of a sustained-release preparation (Theo-Dur) with a conventional preparation (Nuelin) in the treatment of chronic asthma. ( Haahtela, T; Kulstad, S; Vilkka, V, 1983) |
| "A comparison of pharmacokinetics and therapeutic effects of a standard oral theophylline preparation (Choline Theophyllinate) and controlled release aminophylline (Phyllocontin) was made in two parallel double blind trials in 25 children with chronic asthma." | 5.05 | A comparative trial of choline theophyllinate and controlled release aminophylline in chronic childhood asthma. ( Helms, P; Pearl, K; Wilson, R, 1983) |
| "In a double-blind study we compared the effect of 2 mg ketotifen (Zaditen) daily and 1050 mg aminophylline daily for 6 months in two groups of altogether 24 patients with bronchial asthma and a chronic obstruction of the airways." | 5.05 | The influence of ketotifen and aminophylline on the central and peripheral airways. ( Dorow, P; Schiess, W, 1983) |
| "A higher incidence of fatal asthma after increased use of combined inhaled beta 2-agonists and theophylline has been attributed to additive cardiac toxicity of these agents." | 5.05 | Concomitant bitolterol mesylate aerosol and theophylline for asthma therapy, with 24 hr electrocardiographic monitoring. ( Chervinsky, P; Kemp, JP; Meltzer, EO; Mingo, TS; Noyes, JH; Orgel, HA, 1984) |
| "There is evidence that theophylline therapy inhibits lower esophageal sphincter pressure and enhances gastroesophageal reflux in normal adults and adult asthmatics." | 5.05 | Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy. ( Berquist, WE; Katz, R; Rachelefsky, GS; Rowshan, N; Siegel, S; Welch, M, 1984) |
| "A double-blind randomised controlled trial was conducted to study the effects of oral theophylline alone compared with oral theophylline and salbutamol in a sample of asthmatic children." | 5.05 | Effects of oral theophylline and oral salbutamol in the treatment of asthma. ( Dawson, KP; Fergusson, DM, 1982) |
| "Twenty-one patients, suffering from bronchial asthma, with a moderate and clearly reversible airway obstruction, completed a double-blind cross-over trial of two theophylline sustained-release preparations, Theolair Retard (= Theolair S." | 5.05 | A double-blind comparative trial between two sustained-release theophylline preparations with individual doses in asthmatic in-patients. ( Van Alphen, AC; Van Altena, R; Van der Meer, YG; Van Loenen, AC, 1982) |
| "The effect of adding theophylline to treatment with a beta2-adrenoceptor stimulant was studied in 18 asthmatic children in a double-blind cross-over trial." | 5.05 | Combined treatment with sustained-release theophylline and beta2-adrenoceptor-stimulating agents in chronic childhood asthma. ( Foucard, T; Lindström, B; Lönnerholm, G, 1981) |
| "Slow-release aminophylline, although widely used for the prophylaxis of childhood asthma, has had only limited formal assessment." | 5.05 | Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid? ( Silverman, M; Wilson, N, 1982) |
| "The efficacy of nebulised sodium cromoglycate and an oral theophylline solution at currently recommended doses were compared in one to six-year-old children with chronic asthma." | 5.05 | Comparison of nebulised sodium cromoglycate and oral theophylline in controlling symptoms of chronic asthma in pre-school children: a double blind study. ( Newth, CJ; Newth, CV; Turner, JA, 1982) |
| "The treatment of chronic asthma with a sustained-release theophylline preparation was evaluated in a placebo controlled, 2 X 4 week, randomised, double-blind study." | 5.05 | Long-term treatment with oral sustained-release theophylline. ( Bundgaard, A; Weeke, B, 1982) |
| "The serum theophylline concentration profiles and clinical efficacy of two sustained-release theophylline tablets (Quibron-T/SR and Theo-Dur) were compared in 13 asthmatic children requiring continuous theophylline therapy." | 5.05 | Sustained-release theophylline. Pharmacokinetic and therapeutic comparison of two preparations. ( Howick, J; Kelly, HW; McWilliams, BC; Menendez, R, 1983) |
| "Oral administration of salbutamol and theophylline has been shown to be effective in relieving bronchoconstriction in asthmatic children aged between 3 and 5 years." | 5.05 | Efficacy of orally administered salbutamol and theophylline in pre-schoolchildren with asthma. ( Groggins, RC; Lenney, W; Milner, AD; Stokes, GM, 1980) |
| "In a double-blind controlled trial 14 chronic asthmatic patients with regular nocturnal exacerbations took 16 mg slow-release oral salbutamol (two Ventolin spandets), 450 mg slow-release aminophylline (two Phyllocontin Continus tablets), or placebo at midnight." | 5.05 | Slow-release oral salbutamol and aminophylline in nocturnal asthma: relation of overnight changes in lung function and plasma drug levels. ( Davies, HJ; Fairfax, AJ; McNabb, WR; Spiro, SG, 1980) |
| "We examined the value of maintenance theophylline at serum concentrations of 10 to 20 micrograms per milliliter in a placebo-controlled, randomized, double-blind trial of 33 children with steroid-dependent chronic asthma." | 5.05 | The value of maintenance theophylline in steroid-dependent asthma. ( Huntley, W; Nassif, EG; Thompson, R; Weinberger, M, 1981) |
| "The bronchodilator response to aerosolized terbutaline and optimal doses of theophylline, given singly and in combination, was studied in ten patients with perennial asthma." | 5.05 | Theophylline and aerosolized terbutaline in the treatment of bronchial asthma. Double-blind comparison of optimal doses. ( Nelson, HS; Smith, JA; Weber, RW, 1980) |
| "This study compared the efficacy of single oral doses of a new beta adrenergic agonist-xanthine derivative, reproterol, with placebo by measuring the degree of induced bronchodilation and inhibition of response to methacholine challenge in patients with bronchial asthma." | 5.05 | Inhibition of methacholine-induced bronchoconstriction with reproterol, a new beta agonist-xanthine derivative. ( Hunt, EJ; Klaustermeyer, WB; Kuhn, GJ; Santiago, SM; Wehiky, I, 1981) |
| "The purpose of this study was to compare the efficacy of a new bronchodilator, reproterol with standard bronchodilators terbutaline and theophylline in patients with allergic asthma." | 5.05 | Inhibition of antigen-induced bronchoconstriction with reproterol, a new beta agonist-xanthine derivative. ( Klaustermeyer, WB; Kuhn, GJ; Santiago, SM; Weliky, I, 1981) |
| "The authors give a synopsis of the results of a clinical efficacy trial involving a comparison of a new synthetic xanthine derivative (CK 0383) and theophylline, with emphasis on the prevention of exercise-induced asthma (EIA) by both theophylline and the new drug." | 5.05 | Clinical efficacy trial: theophylline vs (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione. ( Casali, L; Grassi, C; Rampulla, C; Rossi, A, 1980) |
| ": reproterol (Bronchospasmin), terbutalin (Bricanyl) and fenoterol (Berotec) were examined in a randomized study in 90 patients." | 5.05 | [Postoperative respiratory therapy: bronchospasmolytic activity and side-effects of some recently introduced beta-sympatheticomimetic agents (author's transl)]. ( Beer, S; Brandl, M; Hamer, P, 1981) |
| " Adult asthmatic patients who demonstrated greater than or equal to 20% improvement in FEV1 after inhalation of aerosolized isoproterenol or its equivalent and greater than or equal to 20% reduction in FEV1 after a graded treadmill exercise received theophylline (3, 6 mg/Kg, every 6 h) for 4 days." | 5.05 | A double-blind, placebo-controlled evaluation of (dl)-3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione in exercise-induced bronchospasm. ( Cho, YW; Han, HC; Kuemmerle, HP; Maines, JE; OH, SY, 1981) |
| "Salbutamol increased significantly the bronchodilating effect of proxyphylline both in experimental animals and in asthmatic patients." | 5.05 | Interaction between proxyphylline and salbutamol. ( Allonen, H; Kanto, J; Kulmala, T; Mäntylä, R; Tala, E, 1981) |
| "The efficacy of metaproterenol (orciprenaline) and theophylline given orally at currently recommended doses was examined in 34 children with chronic asthma using a randomized double-blind cross-over evaluation of four weeks' duration for each active regimen." | 5.05 | Comparison of orally administered metaproterenol and theophylline in the control of chronic asthma. ( Dusdieker, L; Ekwo, EE; Green, M; Smith, GD; Weinberger, M, 1982) |
| "Eleven asthmatic children less than six years were treated double-blind for eight weeks with fenoterol, theophylline or placebo syrups." | 5.05 | Comparison of the long-term effect of fenoterol hydrobromide and theophylline syrups in pre-school asthmatic children. ( Levison, H; Mindorff, C; Nolan, G; Reilly, PA, 1982) |
| "Twenty asthmatic children who had daily wheezing requiring constant medication as outpatients were given oral metaproterenol or oral theophylline in a randomized double-blind crossover study." | 5.05 | A comparison of metaproterenol and theophylline for control of childhood asthma. ( Oppenheimer, PJ; Schuller, DE, 1982) |
| "In an effort to determine the optimal emergency therapy for acute episodes of asthma, we randomly, assigned 102 acute ill patients to 60 minutes of treatment with inhaled isoproterenol alone, isoproterenol plus intravenous aminophylline or isoproterenol plus a single oral dose of an elixir of theophylline." | 5.05 | Emergency room of treatment of asthma. Relationships among therapeutic combinations, severity of obstruction and time course of response. ( Fanta, CH; McFadden, ER; Rossing, TH, 1982) |
| "Therapeutic response to theophylline in asthma is generally attributed to its effect in increasing intracellular 3',5' cyclic adenosine monophosphate (cAMP) by competitive inhibition of cAMP phosphodiesterase." | 5.05 | Stimulation of endogenous catecholamine release by theophylline: a proposed additional mechanism of action for theophylline effects. ( Galant, SP; Higbee, MD; Kumar, M, 1982) |
| "The bioavailability of three different theophylline tablets (microcrystallinic theophylline, Theolair, Nuelin, 3M Riker), choline theophyllinate as a new film-coated tablet (Teovent, Ferrosan, Sweden) and theophyllaminopropanol (Oxyphylline, Draco, Sweden) was investigated in eight adult asthmatics and a randomized, double-blind, cross-over study." | 5.05 | Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation. ( Mellstrand, T; Svedmyr, K; Svedmyr, N, 1982) |
| "The effects of oral doses of theophylline and a beta-adrenergic agonist, fenoterol, were examined in 18 asthmatic young adults." | 5.05 | The effects of oral doses of theophylline and fenoterol on exercise-induced asthma. ( Beasley, PP; Eggleston, PA; Kindley, RT, 1981) |
| "Theophylline concentrations in saliva have been compared with those in serum in 13 asthmatic patients after single and multiple oral dosage of a microcrystalline theophylline tablet (Nuelin) and a sustained-release preparation (Nuelin Retard)." | 5.05 | Theophylline concentrations in serum and saliva after oral microcrystalline and sustained-release preparations in asthmatics. ( Munch, EP; Søndergaard, I; Weeke, B, 1981) |
| "The capacity of single oral doses of theophylline, ephedrine and hydroxyzine, alone and in combination, to prevent antigen-induced changes in airways dynamics was compared in patients with seasonal asthma." | 5.05 | Combined vs. single-entity pharmacologic inhibition of induced asthma. ( Falliers, CJ; Redding, MA, 1980) |
| "Forty-eight patients who presented with acute episodes of asthma were randomized to treatment with subcutaneously administered epinephrine, inhaled isoproterenol, or intravenously administered aminophylline." | 5.05 | Emergency therapy of asthma: comparison of the acute effects of parenteral and inhaled sympathomimetics and infused aminophylline. ( Fanta, CH; Goldstein, DH; McFadden, ER; Rossing, TH; Snapper, JR, 1980) |
| "In a double blind crossover experiment the protective effect of theophylline slow-releasing coated tablets (Euphyllin retard) on exercise-induced asthma has been compared with that of a placebo." | 5.05 | [Euphyllin retard and "exercise-induced" asthma]. ( Ahrens, J; Bachofen, H; Kyd, K; Röthlisberger, U; Scherrer, M, 1980) |
| "Metaproterenol (M) and theophylline (T) were compared in an eight-week randomized, double-blind, crossover study in 20 moderately severe asthmatic children." | 5.05 | Metaproterenol and theophylline in asthmatic children. ( Katz, RM; Mickey, MR; Rachelefsky, GS; Siegel, SC, 1980) |
| "Bronchodilation and side effects of 28 days treatment with either a full therapeutic dose of theophylline slow-release preparation 500 mg twice daily (400-600 mg), a slow-release terbutaline preparation 10 mg twice daily or combinations of the 2 drugs in full or half doses were evaluated in 31 asthmatic outpatients in a double-blind, randomized crossover design." | 5.05 | Long-term oral therapy of asthma with terbutaline and theophylline, alone and combined. ( Gnosspelius, Y; Gymose, E; Laursen, LC; Taudorf, E; Weeke, B, 1985) |
| "We studied 40 patients with acute exacerbations of asthma to determine the efficacy of a 3-h intravenous infusion of aminophylline in patients who were already being treated with an inhaled beta-adrenergic agonist (metaproterenol)." | 5.05 | Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma. ( Gelb, A; Sheppard, D; Siegel, D; Weinberg, PF, 1985) |
| "In a placebo-controlled, double-blind cross-over study of 2 X 3 weeks' duration, twenty-four children with stable asthma who were wheezing during the night, were treated with a single dose of sustained-release theophylline (SRT) taken after supper." | 5.05 | Treatment of nocturnal asthma in children with a single dose of sustained-release theophylline taken after supper. ( Pedersen, S, 1985) |
| "1 mg/kg/6 hr) or placebo to 2- to 6-year old children whose extrinsic asthma was treated with maintenance theophylline in a prerandomized, double-blind crossover study design." | 5.05 | Albuterol syrup in the treatment of asthma. ( Bierman, CW; Furukawa, CT; Pierson, WE; Shapiro, GG, 1985) |
| "Three hundred seventy-four patients with asthma were entered into a year-long, double-blind, double-placebo controlled study comparing the prophylactic effect of ketotifen (229 patients), theophylline (73 patients), and placebo (72 patients)." | 5.05 | A multicenter trial of the prophylactic effect of ketotifen, theophylline, and placebo in atopic asthma. ( Buckley, CE; Bukantz, SC; Chodosh, S; Cohen, BM; Dobken, JH; Moss, BA; Rappaport, I; Rosenthal, RR; Sheffer, AL; Tinkelman, DG, 1985) |
| "A double-blind crossover comparison of a 12-hour theophylline preparation (Theo-Dur) and a 24-hour theophylline preparation (Theo-24) was conducted with 20 young adult chronic asthmatic patients requiring daily bronchodilator therapy." | 5.05 | A comparative trial of the clinical efficacy and pharmacokinetics of 12-hour and 24-hour controlled release theophylline preparations in patients with chronic asthma. ( Decouto, J; Edelman, L; Janky, DG; Miller, E; Tinkelman, DG, 1985) |
| "Eight asthmatic out-patients with a history of exercise-induced asthma (EIA) were randomly treated with intravenously administered enprofylline 1." | 5.05 | Effects of enprofylline and theophylline on exercise-induced asthma. ( Johannesson, N; Laursen, LC; Weeke, B, 1985) |
| "Twenty-seven asthmatic outpatients were randomly treated with bambuterol 30 mg administered once daily before going to bed and sustained release terbutaline 10 mg twice daily in a 14 day, double blind cross over study." | 5.05 | Bambuterol: effects of a new anti-asthmatic drug. ( Faurschou, P; Gnosspelius, Y; Laursen, LC; Pedersen, BK; Weeke, B, 1985) |
| "Treatment of chronic perennial childhood asthma with cromolyn sodium (CS) or long-acting theophylline (LAT) was compared in 13 children by a double-blind, cross-over trial in which each drug was administered for 4 wk." | 5.05 | Clinical, physiologic, and psychologic comparison of treatment by cromolyn or theophylline in childhood asthma. ( Ben Dov, I; Godfrey, S; Goldenberg, B; Springer, C, 1985) |
| "Nocturnal wheeze is common in patients with asthma, and slow release theophyllines may reduce symptoms." | 5.05 | Sustained release choline theophyllinate in nocturnal asthma. ( Connaughton, JJ; Douglas, NJ; Flenley, DC; McFie, J; Rhind, GB, 1985) |
| "Seven hundred and thirty-three atopic asthmatic patients were entered into two multicenter double-blind double-placebo controlled studies comparing the prophylactic effects of ketotifen (445 patients), placebo (143 patients), disodium cromoglycate (72 patients) and theophylline (73 patients)." | 5.05 | A multicenter study with ketotifen (Zaditen). ( Burns, RB, 1985) |
| "The literature is unclear as to whether theophylline loading doses should be based on total body weight (TBW) or ideal body weight (IBW)." | 5.05 | Volume of distribution of theophylline in acute exacerbations of reversible airway disease. Effect of body weight. ( Curtis, RA; Fischer, JH; Troyer, WG; Zell, M, 1985) |
| "We studied the effect of oral terbutaline on serum theophylline levels in 12 children with asthma." | 5.05 | Reduction of serum theophylline levels by terbutaline in children with asthma. ( Danziger, Y; Garty, M; Ilfeld, D; Rosenfeld, JB; Varsano, I; Volwitz, B, 1985) |
| "The airway response to increasing concentrations of inhaled-adenosine and histamine after oral theophylline or matched placebo was studied in nine asthmatic subjects." | 5.05 | Specific antagonism of adenosine-induced bronchoconstriction in asthma by oral theophylline. ( Holgate, ST; Mann, JS, 1985) |
| "In 15 asthmatic children and 3 healthy adult volunteers the pharmacokinetics and pharmacodynamics of proxyphylline under oral treatment, and the pharmacokinetics after intravenous administration were determined." | 5.05 | [Pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children]. ( Kalla, M; Reinhardt, D; Richter, O, 1985) |
| "The bronchodilator effect of a 10 mg/kg dose of theobromine (3,7-dimethylxanthine) was compared with that of 5 mg/kg of theophylline (1,3-dimethylxanthine) in young patients with asthma." | 5.05 | The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma. ( Becker, AB; Gillespie, CA; Simons, FE; Simons, KJ, 1985) |
| "Nine adult subjects with perennial bronchial asthma participated in a single-blind, cross-over, placebo-controlled study to evaluate and compare the effectiveness of a 24-hour sustained-release theophylline formulation, Uniphyl, with that of a twice-daily compound, Theo-Dur." | 5.05 | Pharmacokinetics and clinical response to single- and multiple-dose sustained-release theophylline compounds in perennial bronchial asthma. ( Fanta, CH; McFadden, ER, 1985) |
| "The bronchodilator effects of 375 mg theophylline orally and 200 microg salbutamol by pressurized aerosol were compared in a randomized, cross-over, double-blind trial in fourteen asthmatic patients." | 5.04 | Comparison of oral theophylline and salbutamol by inhalation in asthmatic patients. ( Hartnett, BJ; Marlin, GE, 1976) |
| "28 children with chronic asthma (15 in Denver and 13 in London) completed a 12 wk double-blind trial of treatment with sodium cromoglycate (cromolyn sodium), theophylline, and a combination of both." | 5.04 | Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study. ( Bell, T; Cavanaugh, M; Ginchansky, E; Godfrey, S; Greenberg, S; Hambleton, G; Taylor, J; Tooley, M; Weinberger, M, 1977) |
| ", theophylline) can have a prophylactic effect on natural or experimentally induced asthma by maintaining high levels of cyclic AMP in the target organ cells." | 5.04 | Pharmacologic modification of induced asthma. ( Falliers, CJ; Katsampes, CF, 1976) |
| "In a single-blind, crossover study 10 adult asthmatic patients received a theophylline-ephedrine combination tablet (theophylline 90 mg, ephedrine 16 mg and phenobarbital 25 mg in an immediate release layer and theophylline 90 mg and ephedrine 32 mg in a sustained release layer) twice daily or terbutaline 5 mg three times daily for two weeks." | 5.04 | A comparison of a theophylline-ephedrine combination with terbutaline. ( Alcala, JC; Bush, RK; Lee, TP; Smith, AM; Welling, PG, 1978) |
| "12 patients with bronchial asthma received treatment with Ketotifen for three months." | 5.04 | [Ketotifen, a new prophylactic agent in asthma (author's transl)]. ( Fryda-Kaurimsky, Z; Giesen, HK, 1979) |
| "Sixteen asthmatic children between the ages of 7 and 13 years, 13 of whom were receiving theophylline orally around-the-clock, were studied for eight weeks in double-blind manner to evaluate efficacy, toxicity, and development of tolerance to the combination of ephedrine sulfate and theophylline." | 5.04 | Ephedrine therapy in asthmatic children. Clinical tolerance and absence of side effects. ( Avner, SE; Tinkelman, DG, 1977) |
| "The bioavailability, duration of action, and efficacy of a crystallized tablet form of theophylline were studied in 16 nonsteroid-dependent asthmatic children." | 5.04 | The effectiveness of the short- and long-term use of crystallized theophylline in asthmatic children. ( Katz, RM; Rachelefsky, GS; Siegel, S, 1978) |
| "In a double-blind, crossover study a sustained release theophylline preparation was found to be effective and safe while controlling the symptoms and improving the measured pulmonary function of 16 chronic childhood asthmatics." | 5.04 | A sustained release theophylline preparation: efficacy in childhood asthma with low serum theophylline levels. ( Katz, RM; Rachelefsky, GS; Siegel, SC, 1978) |
| "5 mg hydroxyzine hydrochloride were compared in a double-blind cross-over placebo-controlled study in 12 patients with chronic reversible bronchial asthma." | 5.04 | The efficacy of oral theophylline and the combination of theophylline + hydroxyzine in chronic bronchial asthma. ( Lahdensuo, A, 1978) |
| "5 mg) and 2% (5 mg) reproterol aerosol was investigated in 30 patients with chronic obstructive bronchitis and asthma." | 5.04 | [Bronchospasmolytic effect of reproterol as aerosol (author's transl)]. ( Aurich, R; Voss, H, 1979) |
| "11 asthmatic outpatients were treated with placebo, ephedrine + theophylline + hydroxyzine, ephedrine + theophylline, and ephedrine + hydroxyzine, orally t." | 5.04 | Objective and subjective assessment of ephedrine combinations in asthmatic outpatients. ( Mattila, MJ; Muittari, A, 1979) |
| "A double-blind cross-over trial was conducted to evaluate the effectiveness of oral theophylline-7-acetic acid (T7AA) in 13 asthmatic patients." | 5.04 | Theophylline-7-acetic acid: lack of absorption and therapeutic effectiveness. ( Fleetham, JA; May, B; Munt, PW; Nakatsu, K; Owen, JA, 1979) |
| "Exercise-induced bronchospasm was induced by treadmill running in 12 children on two days preceding either inhaled cromolyn sodium (Intal) or oral theophylline (Slo-Phyllin tablets), 7." | 5.04 | Relationship of serum theophylline concentration to inhibition of exercise-induced bronchospasm and comparison with cromolyn. ( Cooper, D; Kiechel, F; Pollock, J; Weinberger, M, 1977) |
| "A prolonged therapeutic effect following a single oral dose of theophylline and maintenance of an adequate therapeutic blood level of theophylline is an important factor in the management of chronic bronchial asthma." | 5.04 | Pharmacodynamic and spirometric responses to a sustained-release theophylline capsule. ( Falliers, CJ, 1979) |
| "The acute bronchodilator effect of the beta 2-adrenoceptor agonist terbutaline was tested single-blind cross-over in out-patients with chronic obstructive airways disease (intrinsic asthma)." | 5.04 | [Lung function studies with the bronchodilator terbutaline]. ( Bonelli, J; Hitzenberger, G; Kaik, G; Laggner, A; Magometschnigg, D, 1979) |
| "The effects of administration of single doses of 10 mg/kg of two sustained release theophylline preparations were compared in a double-blind, crossover study in eight asthmatic children." | 5.04 | Comparison of Theolair SR and Theo-Dur tablets. ( Domson, JF; Hein, EW; Sheen, A; Sly, RM, 1979) |
| "A double-blind crossover trial was conducted in 10 asthmatic patients for comparison of fenoterol with salbutamol, in 12 other asthmatic patients for comparison of reproterol with salbutamol, and in 15 other asthmatic patients for comparison of terbutaline with salbutamol." | 5.04 | [The bronchospasmolytics salbutamol, fenoterol, terbutaline and reproterol. Their effects and side effects in asthmatics after inhalation with an electric nebulizer]. ( Budmiger, H; Kyd, K; Scherrer, M, 1978) |
| "Reproterol (Bronchospasmin), a monomolecular combination of catecholamine and theophylline, was tested in 81 patients with bronchial asthma or chronic obstructive bronchitis after a single oral dose, and compared with orciprenaline by intra-individual cross-over test." | 5.04 | [A multi-centre study of reproterol, a bronchodilator (author's transl)]. ( Galgóczy, G; Lode, H; Mándi, A; Matthys, H; Nolte, D; Stresemann, E, 1977) |
| "The effectiveness and safety of individualized theophylline doses administered as such and in combination with ephedrine and hydroxyzine was investigated in 23 children with chronic asthma who received these medications and a placebo for 1 week each, double-blind and in randomized sequence." | 5.04 | Interaction of ephedrine and theophylline. ( Bensch, GW; Bock, GN; Bronsky, E; Weinberger, M; Yecies, JJ, 1975) |
| "The relative effectiveness of ephedrine, theophylline, and hydroxyzine hydrochloride and their combinations was studied in a two-part investigation of 16 youths who has asthma and exercise-induced asthma." | 5.04 | Exercise-induced asthma. Pharmacological assessment of single drugs and drug combinations. ( Bierman, CW; Pierson, WE; Shapiro, GG, 1975) |
| "The relative effectiveness of ephedrine, theophylline, hydroxyzine, and their combinations in relieving cycloergometer exercise-induced asthma were studied in 16 children and adolescents." | 5.04 | The pharmacological assessment of single drugs and drug combinations in exercise-induced asthma. ( Bierman, CW; Pierson, WE; Shapiro, GG, 1975) |
| "Theophylline has been used for decades to treat both acute and chronic asthma." | 4.98 | Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis. ( Li, J; Mahemuti, G; Ren, L; Tieliwaerdi, N; Zhang, H, 2018) |
| " Natural products have been a rich source of drug discovery, Theophylline and Methylxanthine originated from tea leaves used for asthma treatment, whereas, Papaverine, a natural isoquinolein originated from Papaver somniferum traditionally used in impotency, altogether as caffeine where firstly described as PDE-inhibiting compounds." | 4.95 | Therapeutic potentials of natural compounds acting on cyclic nucleotide phosphodiesterase families. ( Abusnina, A; Lugnier, C, 2017) |
| "Theophylline is an orally acting xanthine that has been used since 1937 for the treatment of respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD)." | 4.95 | Xanthines and Phosphodiesterase Inhibitors. ( Page, CP; Spina, D, 2017) |
| " The benefits of methylxanthine-based therapies in the apnea of prematurity and their translational potential in pediatric affections of the respiratory tract are here presented." | 4.93 | The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. ( Franco, R; Martínez-Pinilla, E; Oñatibia-Astibia, A, 2016) |
| "Intravenous theophyllines are a second line treatment for children suffering an acute exacerbation of asthma." | 4.93 | The Evidence for Intravenous Theophylline Levels between 10-20mg/L in Children Suffering an Acute Exacerbation of Asthma: A Systematic Review. ( Cooney, L; Hawcutt, D; Sinha, I, 2016) |
| "inhaled magnesium sulphate in acute asthma was shown to improve lung function measures (one trial, 60 women); intravenous theophylline in acute asthma was not associated with benefits (one trial, 65 women)." | 4.90 | Interventions for managing asthma in pregnancy. ( Bain, E; Clifton, VL; Crowther, CA; Hodyl, NA; Middleton, P; Pierides, KL; Stark, MJ, 2014) |
| "Xanthines like theophylline have long been recognised as being effective drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD)." | 4.90 | Phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. ( Page, CP, 2014) |
| "Addition of theophylline to ICS has similar therapeutic effects on improving lung function as increasing the dose of ICS in the treatment of symptomatic asthma." | 4.87 | Addition of theophylline or increasing the dose of inhaled corticosteroid in symptomatic asthma: a meta-analysis of randomized controlled trials. ( Liao, X; Lin, K; Wang, C; Wang, Y, 2011) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: adding anti-IgE treatment; beta(2) agonists (adding long-acting inhaled beta(2) agonists when asthma is poorly controlled by inhaled corticosteroids, or short-acting inhaled beta(2) agonists as needed for symptom relief); inhaled corticosteroids (low dose and increasing dose); leukotriene antagonists (with or without inhaled corticosteroids); and theophylline (when poorly controlled by inhaled corticosteroids)." | 4.87 | Asthma in adults. ( Dennis, RJ; Rodrigo, G; Solarte, I, 2011) |
| "Afebrile seizures associated with rotavirus gastroenteritis, respiratory syncytial virus bronchiolitis, influenza infection, asthma, blood transfusions, and intake of a number of drugs (including theophylline, cephalosporins, metronidazole, and acyclovir) with therapeutic drug levels are uncommonly encountered in clinical practice." | 4.85 | Common causes of uncommon seizures. ( Boustany, RM; El-Bitar, MK, 2009) |
| "Doxofylline, a methylxanthine derivative, has recently drawn attention because of its better safety profile and similar efficacy over the most widely prescribed analogue, theophylline, indicated for asthma and chronic obstructive pulmonary disease." | 4.85 | Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. ( Chakraborty, S; Mishra, B; Shukla, D; Singh, S, 2009) |
| "Theophylline and long acting beta-2 agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma." | 4.84 | Long-acting beta2-agonists versus theophylline for maintenance treatment of asthma. ( Gibson, PG; Irving, LB; Koh, MS; Lasserson, TJ; Tee, AK; Wilson, AJ, 2007) |
| " theophylline) in the maintenance treatment of paediatric asthma." | 4.83 | Oral xanthines as maintenance treatment for asthma in children. ( Bara, A; Ducharme, FM; Lasserson, TJ; Seddon, P, 2006) |
| "Theophylline has been relegated to a second- or even third-line therapy in the treatment of asthma and chronic obstructive pulmonary disease (COPD), behind glucocorticosteroids and beta2-agonists, although recent findings have suggested that theophylline possesses anti-inflammatory and immunomodulatory effects in addition to its well-recognized effects as a bronchodilator." | 4.83 | Are phosphodiesterase 4 inhibitors just more theophylline? ( Boswell-Smith, V; Cazzola, M; Page, CP, 2006) |
| "Medications identified for the treatment of recurrent wheezing in preschool children by the Expert Panel Report of the NHLBI Guidelines for the Diagnosis and Management of Asthma include inhaled corticosteroids, chromones, theophylline, and leukotriene pathway modifiers." | 4.82 | Anti-inflammatory treatment for recurrent wheezing in the first five years of life. ( Gourgoulianis, K; Kaditis, AG; Winnie, G, 2003) |
| "The therapeutic strategy is much the same as for younger asthmatics but certain aspects take on greater importance: concerns about osteoporosis with long-term corticosteroid therapy (both oral and inhaled), the risk of arrhythmias with beta-2 adrenergic drugs and the significant side-effects of theophylline justifies, in difficult cases, consideration of anti-cholinergic and/or anti-leukotriene therapy." | 4.82 | [Asthma in the elderly]. ( Radenne, F; Tonnel, AB; Verkindre, C, 2003) |
| "Mice rendered adenosine deaminase-deficient manifest an 'asthma' phenotype in the lungs that includes mast cell degranulation, eosinophilia, mucus hypersecretion and bronchial hyperresponsiveness." | 4.82 | The case for a role for adenosine in asthma: almost convincing? ( Fozard, JR, 2003) |
| "Theophylline and long acting beta-2 agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma." | 4.82 | Long acting beta-agonists versus theophylline for maintenance treatment of asthma. ( Coughlan, J; Gibson, PG; Shah, L; Wilson, AJ, 2003) |
| "Despite having been recognized for a long time as a cheap and effective therapy for the treatment of asthma and chronic obstructive pulmonary disease (COPD), theophylline is relegated to third-line therapy in the treatment of airway diseases due to the drug's frequent side effects and relatively low efficacy." | 4.82 | Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease. ( Barnes, PJ; Erin, EM; Hansel, TT; Higgins, LA; Neighbour, H; Tan, AJ; Tennant, RC, 2004) |
| "Theophylline has been reduced usage in asthma and chronic obstructive pulmonary disease because of the high frequency of side effects and the relatively low efficacy." | 4.82 | [Development of theophylline in treatment of asthma and chronic obstructive pulmonary disease]. ( Xu, YJ, 2004) |
| "These results indicated that the expression of A2bAR mRNAs in PBMCs was more remarkable in asthmatics than in healthy subjects; that adenosine or IL-1 potentiated the mRNA expression of A2bAR in PBMCs in asthmatic patients, which was correlated with allergy state and the degree of airway obstruction; and that theophylline might antagonize adenosine by inhibiting A2bAR mRNA." | 4.81 | [The effects of adenosine, interleukin-1 and theophylline on the expression of A2 adenosine receptor mRNAs in peripheral blood mononuclear cells from asthmatic patients]. ( Lin, Y; Wang, Z; Zhou, X; Zhu, Y, 2001) |
| "The aim of this study was to compare the efficacy and safety of salmeterol vs theophylline in asthma management using meta-analysis of clinical trials." | 4.80 | The efficacy and safety of salmeterol compared to theophylline: meta-analysis of nine controlled studies. ( Brooks, G; Davies, B; Devoy, M, 1998) |
| "Theophylline has been used for over a century in the treatment of asthma and while it is used principally as a bronchodilator, a number of recent studies have demonstrated potential anti-inflammatory and immunomodulatory activity." | 4.80 | The role of theophylline and phosphodiesterase4 isoenzyme inhibitors as anti-inflammatory drugs. ( Landells, LJ; Page, CP; Spina, D, 1998) |
| "The view of theophylline as a second-line bronchodilator in asthma therapy has begun to be reconsidered in recent years as the details of its additional actions on airway inflammation have emerged." | 4.80 | Theophylline and airway inflammation. ( Dent, G; Rabe, KF, 1998) |
| "Many clinical trials have suggested that theophylline has anti-inflammatory properties in the treatment of bronchial asthma." | 4.80 | Asthma, adenosine, mast cells and theophylline. ( Church, MK; Coward, WR; Sagara, H, 1998) |
| "Low dose theophylline has been shown to reduce requirements for inhaled corticosteroid therapy in patients with asthma and may reduce overall treatment costs." | 4.80 | Theophylline. A review of its potential steroid sparing effects in asthma. ( Faulds, D; Markham, A, 1998) |
| "The use of theophylline for the treatment of asthma for 45 of the past 50 years has been for its ability to dilate bronchi." | 4.80 | Recent advances in our understanding of the use of theophylline in the treatment of asthma. ( Page, CP, 1999) |
| "Theophylline and long acting beta2-agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma." | 4.80 | Long acting beta-agonists versus theophylline for maintenance treatment of asthma. ( Coughlan, J; Gibson, PG; Wilson, AJ, 2000) |
| "Views on the appropriate use of theophylline in asthma management have varied substantially over the past decades." | 4.80 | The role of theophylline in asthma management. ( Kips, JC; Pauwels, RA; Peleman, RA, 1999) |
| "Current Japanese asthma guidelines recommend theophylline as an additional regimen to inhaled beta-agonists (on demand use) and inhaled corticosteroids (beclomethason dipropionate 200-1200 micrograms/day or fluticason propionate 200-800 micrograms/day) for patients whose asthma is not controlled completely." | 4.80 | Theophylline for the treatment of bronchial asthma: present status. ( Kato, M; Kawai, M, 2000) |
| "Theophylline and other methylxanthines are the strongest and most widely used antiasthmatic drugs." | 4.80 | [Undesirable pharmacokinetic interactions of theophylline]. ( Boznański, A; Willak-Janc, E, 2000) |
| "Theophylline has been in clinical use for the treatment of bronchial asthma and other respiratory diseases for well over 50 yrs." | 4.79 | Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma. ( Banner, KH; Page, CP, 1995) |
| "Theophylline has been used for several decades in the treatment of asthma and remains the most widely prescribed anti-asthma drug worldwide, although the development of newer anti-asthma medications, especially inhaled steroids, has resulted in declining use of theophylline in industrialized countries." | 4.79 | Theophylline in the management of asthma: time for reappraisal? ( Barnes, PJ; Pauwels, RA, 1994) |
| "The mechanism of action of theophylline in the treatment of asthma is not yet fully understood." | 4.79 | The changing role of theophylline in pediatric asthma. ( Stoloff, SW, 1994) |
| "Although theophylline has been used in the treatment of lung diseases, particularly bronchial asthma, since the nineteenth century, the mechanisms underlying its effectiveness remained poorly understood until quite recently." | 4.79 | Cyclic nucleotide phosphodiesterases in the human lung. ( Dent, G; Magnussen, H; Rabe, KF, 1994) |
| "An 8-year-old asthmatic child on theophylline was anesthetized with enflurane in nitrous oxide and oxygen." | 4.79 | [Myoglobinuria following anesthesia with enflurane and succinylcholine in an asthmatic child on theophylline]. ( Dan, K; Higa, K; Shono, S; Watanabe, R, 1996) |
| "Theophylline has traditionally been considered for its effect on airway calibre in the treatment of bronchial asthma." | 4.79 | Low-dose theophylline: a new anti-inflammatory role in asthma management? ( Djukanović, R; MacLeod, D, 1996) |
| "Several attempts have recently been made to develop chronotherapy for nocturnal asthma, using theophylline, inhaled corticosteroid, inhaled anticolinergic agent and beta 2-agonist." | 4.79 | [Chronopharmacology and chronotherapy for asthma by using PEF]. ( Burioka, N; Sasaki, T, 1996) |
| " But international consensus report recommends that theophylline should not be used for acute attacks, and reserves theophylline as a second-line drug for the therapy of asthma." | 4.79 | [The development of slow-release theophylline products and revaluation of theophylline's role as a bronchodilator]. ( Mano, K, 1996) |
| "Although theophylline is a widely used drug for the treatment of acute childhood asthma, its efficacy has not been clearly established." | 4.79 | Theophylline in acute childhood asthma: a meta-analysis of its efficacy. ( Brooks, JG; Goodman, DC; Littenberg, B; O'Connor, GT, 1996) |
| "Clinical trials reported in these proceedings have shown that nedocromil sodium is an effective antiasthmatic agent." | 4.78 | A review of some recent clinical studies with nedocromil sodium. ( Wasserman, SI, 1993) |
| " This review focuses on advances and controversies in the therapy of asthma, including issues regarding medications such as inhaled beta 2-agonists, inhaled corticosteroids, cromolyn sodium, and theophylline." | 4.78 | Advances in respiratory therapeutics in children. ( Reisman, JJ, 1993) |
| "Theophylline and its derivatives have been used in the treatment of asthma for over 50 years, but since the advent of more potent bronchodilators their use has become cloaked in controversy." | 4.78 | Theophylline. Current thoughts on the risks and benefits of its use in asthma. ( Nasser, SS; Rees, PJ, 1993) |
| "Theophylline is a safe and effective medication for the management of chronic asthma." | 4.78 | Current issues in the use of theophylline. ( Bender, B; Milgrom, H, 1993) |
| "Two asthmatic children who developed status epilepticus during theophylline treatment followed by semi-coma were reported." | 4.78 | [Two cases of theophylline-associated encephalopathy in childhood: clinical and CT findings]. ( Kawahara, H; Koeda, T; Maegaki, Y; Takeshita, K, 1993) |
| "Nedocromil sodium is a new prophylactic antiasthmatic medication." | 4.78 | [Review of North American studies on nedocromil sodium]. ( Boulet, LP, 1992) |
| "A case of a 81-year-old asthmatic male with Theophylline-induced rhabdomyolysis was reported." | 4.78 | [A case of theophylline-induced rhabdomyolysis following therapy of bronchial asthma]. ( Aoshima, M; Kameyama, S; Kamiya, T; Miyazaki, T; Murai, Y; Yamazaki, M, 1991) |
| "Beta 2-agonists and theophylline compounds are first line drugs and are extensively used in the treatment of acute bronchial asthma." | 4.77 | Round table on antiasthmatic drugs; beta-agonists and theophylline. Workshop on pathogenesis and therapy of bronchial asthma Cortina d'Ampezzo/1-4 April, 1987. ( Boschetti, E; Grassi, V; Tantucci, C, 1989) |
| "In addition to its bronchodilating activity, the antiasthmatic drug theophylline also reduces microvascular permeability and increases mucociliary clearance, diaphragmatic contractility, and circulating catecholamine levels." | 4.77 | New aspects of the therapeutic potential of theophylline in asthma. ( Pauwels, RA, 1989) |
| "Despite widespread use of theophylline in the hospital management of asthma, supportive data justifying its use are sparse." | 4.77 | Is theophylline use justified in acute exacerbations of asthma? ( Abou-Shala, N; Amarshi, N; Ellis, RF; Self, TH, 1989) |
| "Ten studies designed to evaluate the psychological and behavioral effects of the antiasthma agent theophylline in children have been carried out to date." | 4.77 | Psychological problems associated with drug therapy in childhood asthma. ( Creer, TL; Gustafson, KE, 1989) |
| " It is, further, necessary to apply these agents systemically together with theophylline, the best approach to pre-status and status asthmaticus being continuous i." | 4.77 | [Treatment of the severe asthma attack and status asthmaticus]. ( Baur, X, 1989) |
| "Theophylline has been demonstrated to be a useful agent in the therapy of chronic asthma." | 4.77 | Therapeutic monitoring of theophylline. Rationale and current status. ( Bierman, CW; Williams, PV, 1989) |
| "Recent reviews and editorials have indicated that theophylline may not be effective for the therapy of acute severe asthma." | 4.77 | Should we stop using theophylline for the treatment of the hospitalized patient with status asthmaticus? ( Kelly, HW; Murphy, S, 1989) |
| "Theophylline is an important antiasthmatic medication which has bronchodilator properties." | 4.77 | Sustained release theophylline preparations. Practical recommendations for prescribing and therapeutic drug monitoring. ( Glynn-Barnhart, A; Hill, M; Szefler, SJ, 1988) |
| "In relation to antiasthmatic treatment of hospitalized patients with theophyllines, results concerning: a) a retrospective analysis of plasma levels observed over a 18-month period; b) a pharmacokinetic study and consequent determination of an efficient individual posology are reported." | 4.77 | [Importance of the laboratory in optimizing anti-asthma therapy with theophylline]. ( Snidero, M, 1987) |
| "Theophylline has demonstrated a very high degree of clinical efficacy as a prophylactic maintenance drug for chronic asthma when dose levels maintain serum concentrations of 10 to 20 micrograms/ml." | 4.77 | Therapeutic effect and dosing strategies for theophylline in the treatment of chronic asthma. ( Hendeles, L; Weinberger, M, 1986) |
| "Theophylline has emerged as a major prophylactic agent for controlling the symptoms of chronic asthma, but it provides little if any relief of pulmonary symptoms caused by irreversible chronic airways obstruction." | 4.77 | Update on the pharmacodynamics and pharmacokinetics of theophylline. ( Hendeles, L; Massanari, M; Weinberger, M, 1985) |
| "The experimental data providing the rationale for the use of ketotifen as a prophylactic drug in asthma (inhibition of release of the mediators of anaphylaxis, particularly SRS-A, prevention of the bronchospasm induced by SRS-A in vivo, calcium antagonist effect) are briefly discussed, and the results of experimental and therapeutic trials carried out over 6 years in a number of countries in several thousand patients are reviewed." | 4.76 | Ketotifen in the oral prophylaxis of bronchial asthma: a review. ( Craps, L, 1981) |
| "The use of cromolyn sodium (SCG) and high-dose theophylline (HDT) in the treatment of chronic perennial asthma in children is reviewed." | 4.76 | The relative merits of cromolyn sodium and high-dose theophylline therapy in childhood asthma. ( Godfrey, S, 1980) |
| "Even with the availability of new and exciting antiasthmatic drugs, theophylline is emerging as one of the most useful noncorticosterioid agents available for suppressing symptoms in the patient with chronic asthma." | 4.76 | Experience with theophylline for the management of chronic asthma. ( Hendeles, L; Weinberger, M, 1980) |
| "Xanthines, best represented by theophylline, constitute a pharmacological principle of considerable age and importance in the treatment of asthma." | 4.76 | Some pharmacological aspects of xanthines in asthma. ( Persson, CG, 1980) |
| "The acute bronchodilator effect of the beta 2-adrenoceptor agonist terbutaline was tested single-blind cross-over in out-patients with chronic obstructive airways disease (intrinsic asthma)." | 4.76 | [Pulmonary function tests with the bronchodilator Terbutaline]. ( Bonelli, J; Hitzenberger, G; Kaik, G; Laggner, A; Magometschnigg, D, 1979) |
| " These agents are useful by aerosol and oral routes, alone and in addition to theophylline for asthma." | 4.75 | Treatment of asthma with theophylline and beta adrenergic agents. ( Davis, WJ; Feldman, BR, 1976) |
| "Theophylline is a drug commonly used to treat asthma due to its anti-inflammatory and bronchodilatory properties." | 4.31 | Theophylline-Induced Relaxation Is Enhanced after Testosterone Treatment via Increased K ( Carbajal-García, A; Casas-Hernández, MF; Díaz-Hernández, V; Montaño, LM; Reyes-García, J; Sommer, B, 2023) |
| " Multivariable logistic or linear regression was used for the analysis of urinary levels of caffeine or each of its three major metabolites (paraxanthine, theobromine, and theophylline) and current asthma, lung function, and FeNO." | 4.12 | Urinary caffeine and caffeine metabolites, asthma, and lung function in a nationwide study of U.S. adults. ( Celedón, JC; Forno, E; Han, YY, 2022) |
| "Theophylline is commonly used for the treatment of asthma and has a low hepatic clearance." | 3.96 | Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach. ( Alanazi, MM; Alasmari, F; Alqahtani, F; Imran, I; Khalid, R; Majeed, A; Rasool, MF; Saeed, H, 2020) |
| "Although newer and more efficient medicines to treat asthma and COPD has been developed, theophylline is still prescribed and used in 2016, but the incidence and prevalence have decreased markedly since 1997." | 3.88 | Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study. ( Davidsen, JR; Henriksen, DP; Laursen, CB, 2018) |
| " In the present study we investigated the effects of provinol and its combinations with clinically used antiasthmatics: budesonide or theophylline on airway defense mechanisms during experimental allergic asthma." | 3.81 | Effects of provinol and its combinations with clinically used antiasthmatics on airway defense mechanisms in experimental allergic asthma. ( Fraňová, S; Jošková, M; Kazimierová, I; Pecháňová, O; Šutovská, M, 2015) |
| "In clinical practice, patients using ICS alone or combined with theophylline or short-acting b2 agonists had a low percentage of asthma control and a high number of urgent care visits." | 3.81 | Evaluation of asthma control by inhaled corticosteroids in general practice in Thailand. ( Boonsawat, W; Thinkhamrop, B, 2015) |
| "Both theophylline and doxofylline produced enhancements in PFT at different time intervals in both asthma and COPD patients." | 3.81 | Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease. ( Kumar, R; Lal, D; Manocha, S; Ray, A; Vijayan, VK, 2015) |
| "The present work was undertaken with an objective to design a multilayered dosage form of doxofylline, using pastillation technology, for the chronotherapeutic management of nocturnal asthma." | 3.78 | In vitro and in vivo evaluation of multilayered pastilles for chronotherapeutic management of nocturnal asthma. ( Chakraborty, S; Mishra, B; Shukla, D, 2012) |
| " After adjusting for age, sex, smoking, asthma severity, and depressive disorders, analyses indicated that theophylline use was associated with an increased likelihood of SI (OR = 2." | 3.78 | Association between asthma medications and suicidal ideation in adult asthmatics. ( Bacon, SL; Favreau, H; Joseph, M; Labrecque, M; Lavoie, KL, 2012) |
| " To investigate the pharmacokinetics of theophylline in the presence of pyrexia, patients were divided into two groups based on body temperature: a pyrexia group (> or = 38 degrees C) and a non-pyrexia group (< 38 degrees C)." | 3.78 | Influences of pyrexia and age on theophylline clearance in young children with asthma. ( Imai, K; Kihira, K; Kimura, Y; Mimaki, Y; Morita, T; Munehisa, Y; Nomura, H; Yoshikuni, Y, 2012) |
| "Theophylline derivatives have long been recognized as potent bronchodilators for the relief of acute asthma." | 3.78 | Design and synthesis of new 8-anilide theophylline derivatives as bronchodilators and antibacterial agents. ( Alim, AA; Hayallah, AK; Talhouni, AA, 2012) |
| "The subjects were asthma patients who visited the outpatient clinic of Respiratory Medicine, St Luke's International Hospital, between April and October 2003, and were medicated with sustained-release theophylline tablets (Theodur®)." | 3.77 | Usefulness of the simultaneous determination of serum levels of theophylline and its metabolites in patients medicated with theophylline preparation. ( Chohnabayashi, N; Kizu, J; Nasu, H; Nishimura, N; Uchiyama, N; Watanabe, Y, 2011) |
| "The purpose of this study was to prepare a pressure-controlled colon delivery capsule (PCDC) containing theophylline (TPH) dispersion in a lipid matrix as a chronotherapeutic drug delivery system for the treatment of nocturnal asthma." | 3.77 | A new pressure-controlled colon delivery capsule for chronotherapeutic treatment of nocturnal asthma. ( Al-Suwayeh, SA; Bakry Yassin, AE; Barakat, NS; Taha, EI, 2011) |
| "The objective of the present work was to develop a delayed-onset controlled-release colon-targeted system of theophylline, and to achieve the chronotherapy of nocturnal asthma." | 3.77 | Design and optimization of colon-targeted system of theophylline for chronotherapy of nocturnal asthma. ( Amin, AF; Patel, MM, 2011) |
| "The purpose of this research work was to develop and evaluate a chronotherapeutic based colon-targeted drug delivery system of theophylline (THEO) exploiting pH-enzyme sensitive property for the prevention of episodic attack of asthma in early morning." | 3.77 | pH-enzyme di-dependent chronotherapeutic drug delivery system of theophylline for nocturnal asthma. ( Dangi, JS; Dangi, YS; Gupta, M; Jain, SK; Kumar, M; Namdeo, KP; Soni, ML, 2011) |
| "Methylxanthines especially theophylline have been recognized as potent bronchodilators for the relief of acute asthma for over 65 years." | 3.77 | Design and synthesis of some new theophylline derivatives with bronchodilator and antibacterial activities. ( Alim, AA; Elgaher, WA; Hayallah, AM; Salem, OI, 2011) |
| "Theophylline is commonly used to treat severe asthma and chronic obstructive pulmonary disease (COPD) characterized by non-eosinophilic inflammation." | 3.76 | Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma. ( Choi, DS; Choi, JP; Gho, YS; Jeon, SG; Kim, YK; Kim, YS; Moon, HG; Yoon, CM, 2010) |
| "To elucidate the mechanisms of intractable pediatric bronchial asthma and the indication of low-dose erythromycin (EM) therapy, the serum chemokine levels of and the angiogenic factor were evaluated in 55 pediatric patients with bronchial asthma; 7." | 3.76 | The indication and effectiveness of low-dose erythromycin therapy in pediatric patients with bronchial asthma. ( Akiyoshi, K; Izumi, T; Korematsu, S; Maeda, T; Miyahara, H; Nagakura, T; Okazaki, N; Suenobu, S; Yamamoto, K, 2010) |
| " With currently used dosing regimens, theophylline appears to produce relatively constant levels of effect on airway responsiveness and clinical efficacy around the clock, while inhaled beta 2 agonists appear to have insufficient effects at the end of longer dosing intervals." | 3.76 | The effect of theophylline and beta 2 agonists on airway reactivity. ( Ahrens, RC; Joad, J; Milavetz, G, 1987) |
| " The suggestion is made that failure to recognize the nonlinearity of the dose-response curves for bronchodilators has resulted in underestimating their combined action." | 3.76 | Theophylline as a bronchodilator in COPD and its combination with inhaled beta-adrenergic drugs. ( Jenne, JW, 1987) |
| "Theophylline can increase the transepithelial secretion of fluid into the respiratory tract lumen by stimulating the chloride pump which is controlled by cyclic AMP." | 3.76 | Theophylline and mucociliary clearance. ( Ziment, I, 1987) |
| "Asthma is considered as the most relevant pulmonary disease which is located at bronchial airways and oral theophylline is one of the most prescribed drugs for its treatment as it is inexpensive." | 3.75 | Respiratory delivery of theophylline by size-targeted starch microspheres for treatment of asthma. ( Mohammadi, MH; Momeni, A, 2009) |
| ") factors; these recent advances have led to improved individual adjustment of theophylline dosage using serum concentration assays if needed." | 3.75 | [Bronchodilators]. ( Advenier, C; Cerrina, J; Duroux, P, 1984) |
| "We report a case of theophylline-induced hypercalcemia." | 3.74 | [A case of theophylline induced hypercalcemia]. ( Itoh, Y; Kimura, T; Takeshita, Y; Tokita, Y; Toya, Y; Tsurumi, Y; Umemura, S, 2007) |
| "The aim of this study was to assess whether approved pharmacological substances in the treatment of asthma such as corticosteroids or theophylline regulate neurotrophins on a cellular level." | 3.73 | Regulation of NGF and BDNF by dexamethasone and theophylline in human peripheral eosinophils in allergics and non-allergics. ( Dinh, QT; Görges, D; Groneberg, DA; Hanf, G; Kunkel, G; Noga, O; Suttorp, N, 2005) |
| "Study 1) BTCs were measured by Accumeter at the beginning of surgery in asthmatic patients who had been medicated with oral theophylline." | 3.73 | [Perioperative evaluation of a kit for simplified measurement of blood theophylline concentration (Accumeter Theophylline)]. ( Iwasaki, S; Namiki, A; Satoh, J; Yamakage, M, 2005) |
| "To study the effects of doxofylline on calcium-activated potassium (K(Ca)) channels of human peripheral blood eosinophils in asthma." | 3.73 | [Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma]. ( Cai, CQ; Cai, SX; Zhao, HJ; Zhou, B; Zou, F, 2005) |
| "Although viral infection might alter theophylline metabolism in acute asthma, there are some difficulties in detecting infection due to various kinds of viruses in a clinical setting." | 3.73 | Theophylline metabolism in acute asthma with MxA-indicated viral infection. ( Adachi, Y; Fuchizawa, T; Itazawa, T; Miyawaki, T; Murakami, G; Nakabayashi, M, 2006) |
| "Theophylline is a useful drug for the treatment of asthma." | 3.73 | A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD. ( Adachi, M; Fukuda, T; Kihara, N; Makino, S; Miyamoto, T; Nakajima, S; Nishima, S; Ohta, K, 2006) |
| " Theophylline possesses anti-inflammatory activities in asthma." | 3.72 | Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma. ( Chung, KF; Huang, KH; Kuo, HP; Lin, CH; Lin, HC; Liu, SL; Wang, CH; Yu, CT, 2003) |
| "Although theophylline has long been used as a medication for bronchial asthma (BA), much remains to be elucidated about its action on Th2 cells, which play a critical role in the development of BA." | 3.72 | Theophylline suppresses IL-5 and IL-13 production, and lymphocyte proliferation upon stimulation with house dust mite in asthmatic children. ( Kimura, M; Okafuji, I; Yoshida, T, 2003) |
| "Preterm delivery was not associated with asthma diagnosis, severity, or symptoms but was associated with use of controller medications, independent of symptoms, specifically oral steroids and theophylline." | 3.72 | Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies. ( Beckett, WS; Belanger, K; Bracken, MB; Leaderer, BP; Saftlas, A; Triche, EW, 2003) |
| "76 patients with mild bronchial asthma were given long acting theophylline." | 3.72 | [Evaluation of the efficacy of inhaled glucocorticosteroids in mild bronchial asthma]. ( Averina, TK; Goriainov, AD; Il'chenko, VA; Kol'tsun, SS; Paleev, NR; Stotskaia, TV; Terpigorev, SA, 2003) |
| "A large-scale prospective study was conducted in 3810 Japanese elderly (> or =65 years old) patients with asthma or chronic obstructive pulmonary disease (COPD) who had been treated with sustained-release theophylline tablets (THEODUR) at a dose of 400 mg/day for 1-6 months, in principle." | 3.72 | A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD. ( Fukuchi, Y; Grouse, L; Mizutani, R; Ohta, K; Rabe, KF; Rennard, SI; Zhong, NS, 2004) |
| "To assay theophylline blood levels in a sample of Sri Lankan chronic asthmatics taking oral theophylline, and to evaluate a simple and cost effective ultraviolet spectrophotometric assay for theophylline levels in blood." | 3.71 | Theophylline blood levels in Sri Lankan asthmatics: comparison of two methods of assay. ( Balasuriya, WK; Cooray, HC; Fernando, N; Goonetilleke, AK; Munasinghe, TM, 2002) |
| "Metabolic and electrolyte abnormalities, including hypokalemia, hyperglycemia and lactic acidosis, are associated with theophylline overdose." | 3.71 | Lactic acidosis associated with the usual theophylline dose in a patient with asthma. ( Choi, IS; Koh, YI, 2002) |
| "We report a case of acute generalized exanthematous pustulosis (AGEP) in a 64-year-old woman, associated with the use of bamifylline." | 3.71 | Acute generalized exanthematous pustulosis induced by ingestion of bamifylline. ( Criado, PR; Criado, RF; de Mello, JF; Fernandes, MF; Galvão, C; Valente, NY, 2002) |
| ") administration of aminophylline has been used to relieve acute exacerbation of bronchial asthma for almost a century." | 3.71 | [Early replacement of intravenous aminophylline administration with oral theophylline in treating acute exacerbation of asthma]. ( Kamiya, U; Kondo, T; Moue, Y; Ohta, Y; Ono, Y; Syouyama, Y; Tanigaki, T; Tazaki, G, 2001) |
| "The comparative effects of a new theophylline preparation (Theodrip) and aminophylline on blood concentrations of theophylline were examined in 74 patients with asthma." | 3.71 | Comparative effect of theophylline and aminophylline on theophylline blood concentrations and peripheral blood eosinophils in patients with asthma. ( Kato, M; Morita, H; Okada, K; Sakamoto, K; Tatsuta, H, 2001) |
| "We examined effects of theophylline withdrawal in 17 adult asthmatics whose symptoms were well controlled under a treatment of a combination of theophylline and inhaled beclomethasone dipropionate (iBDP)." | 3.71 | Effects of theophylline withdrawal in well-controlled asthmatics treated with inhaled corticosteroid. ( Baba, K; Hattori, T; Kobayashi, T; Koishikawa, I; Niwa, S; Sakakibara, A; Takagi, K; Yagi, T; Yoshida, K, 2001) |
| "To investigate the mechanism of anti-inflammatory action of theophylline on asthma." | 3.71 | Effects of theophylline on CD4+ T lymphocyte, interleukin-5, and interferon gamma in induced sputum of asthmatic subjects. ( Hu, SP; Nie, HX; Wu, XJ; Yang, J, 2002) |
| "To elucidate the mechanism of the anti-inflammatory effect of theophylline, peripheral blood mononuclear cells (PBMCs) collected from patients with bronchial asthma who had a RAST score for Dermatophagoides farinae (Df) > = 3 were stimulated with Df antigen, and the interleukin-4 (IL-4) production by the stimulated PBMCs was determined in the presence and absence of theophylline." | 3.70 | Theophylline suppresses the release of interleukin-4 by peripheral blood mononuclear cells. ( Fukuoka, M; Kubo, H; Muraki, M; Nakahara, H; Nakajima, S; Tohda, Y, 1998) |
| "To investigate whether platelets are activated in asthmatics with increased release of preformed mediators and to investigate the influence of oral administration of theophylline on them." | 3.70 | Activation of platelets in bronchial asthma. ( Haruta, Y; Ishioka, S; Kambe, M; Moritani, C; Yamakido, M, 1998) |
| "This study suggests that theophylline may be antiinflammatory by inhibiting the L-arginine-dependent production of NO in patients with asthma." | 3.70 | Theophylline inhibits the production of nitric oxide by peripheral blood mononuclear cells from patients with asthma. ( Bouboulis, D; Frieri, M; Matin, A; Sansone, GR; Wang, SF, 1998) |
| " To clarify part of the bronchodilating effects of theophylline, lymphocyte cyclic AMP (cAMP) and phosphodiesterase (PDE) activity in asthmatic patients and healthy adults were measured." | 3.70 | Effects of theophylline on lymphocyte phosphodiesterase activity. ( Fukuoka, M; Kubo, H; Nakahara, H; Nakajima, S; Ohkawa, K; Tohda, Y, 1998) |
| "79 male and 97 female asthma patients who were treated with theophylline and other drugs between June 1994 and September 1996 were studied." | 3.70 | Decrease in emergency room or urgent care visits due to management of bronchial asthma inpatients and outpatients with pharmaceutical services. ( Murata, M; Ohta, M; Watanabe, T; Yamamoto, T, 1998) |
| "A 53-year-old cocaine user was on chronic therapy with theophylline, albuterol, and ipratropium for asthma and nifedipine for hypertension." | 3.70 | Nonconvulsive status epilepticus in theophylline toxicity. ( Krieger, AC; Takeyasu, M, 1999) |
| "The first regular treatment with inhaled corticosteroids initiated in the year following the recognition of asthma can reduce the risk of admission to hospital for asthma by up to 80% compared with regular treatment with theophylline." | 3.70 | First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma. ( Blais, L; Boivin, JF; Ernst, P; Suissa, S, 1998) |
| "Eight adult patients with mild bronchial asthma and normal liver function were infused aminophylline intravenously (6." | 3.70 | Pharmacokinetics of theophylline metabolites in 8 Chinese patients. ( Cao, W; Chen, G; Ling, SS; Zhuo, HT, 1998) |
| "Hypercalcemia and hypercalciuria observed both in humans and in animals who were on long-term theophylline therapy, prompted us to investigate whether oral theophylline treatment at optimal doses causes any adverse side effects on bone metabolism in mild asthmatics." | 3.70 | Evaluation of the effect of low-dose oral theophylline therapy on some bone turnover markers and serum prolidase I activity in mild asthmatics. ( Büyüköztürk, S; Gürdöl, F; Kolanci, C; Oner, P; Oner-Iyidon, Y, 1999) |
| "The plasma levels of theophylline (TP) and its metabolites were measured in patients with bronchial asthma who were treated with a slow-release preparation of TP." | 3.70 | Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under. ( Arakawa, M; Arakawa, Y; Hayakawa, T; Imai, K; Iwata, T; Kizu, J; Komoda, F; Takamizawa, M, 1999) |
| " The aim of the present study was to investigate the role of adenosine A2b receptors in the anti-proliferative action of theophylline in human peripheral blood mononuclear cells (HPBMC) from healthy and asthmatic subjects." | 3.70 | The role of adenosine receptors in the action of theophylline on human peripheral blood mononuclear cells from healthy and asthmatic subjects. ( Jensen, MW; Landells, LJ; O'Connor, BJ; Orr, LM; Page, CP; Spina, D, 2000) |
| "Theophylline, a known phosphodiesterase inhibitor, has been widely used as an additional bronchodilator in asthmatic patients who are not adequately controlled on high-doses of inhaled steroids." | 3.70 | Theophylline induces a reduction in circulating interleukin-4 and interleukin-5 in atopic asthmatics. ( Baxevanis, CN; Kosmas, EN; Michaelides, SA; Polychronaki, A; Polychronopoulos, V; Roussou, T; Toukmatzi, S, 1999) |
| "We investigated changes in the circadian rhythm of peak expiratory flow (PEF) in seven persons with nocturnal asthma for a 24h span when (1) they were symptom free and their disease was stable, (2) their asthma deteriorated and nocturnal symptoms were frequent, and (3) they were treated with theophylline chronotherapy." | 3.70 | Circadian rhythm in peak expiratory flow: alteration with nocturnal asthma and theophylline chronotherapy. ( Burioka, N; Sako, T; Shimizu, E; Suyama, H, 2000) |
| "In order to study whether a theophylline-related seizure is caused by a decrease in serum vitamin B6, serum pyridoxal (PAL) levels were measured in children with bronchial asthma treated with theophylline." | 3.70 | [Depression of serum pyridoxal levels in theophylline-related seizures]. ( Furukawa, K; Hattori, H; Hayashi, K; Inada, H; Isshiki, G; Kobayashi, N; Matsuoka, O; Seto, T; Tada, H, 2000) |
| "To evaluate the potential inhibitory effect of theophylline on the pulmonary oxidative stress in asthma and chronic obstructive pulmonary disease (COPD), we concomitantly measured the blood levels of theophylline, a non-selective phosphodiesterase (PDE) inhibitor and lipid peroxides as an index of oxidative stress." | 3.70 | Evidence of oxidative stress in asthma and COPD: potential inhibitory effect of theophylline. ( Dobashi, K; Hisada, T; Iizuka, K; Ishizuka, T; Iwamae, S; Mori, M; Shimizu, Y; Tsukagoshi, H, 2000) |
| "To report a case of a patient diagnosed as having bronchial asthma treated with intravenous infusion of theophylline, who presented an episode of altered theophylline metabolism with a disproportionately increase in serum concentrations together with tachycardia and symptoms of intoxication." | 3.70 | Kinetic alteration of theophylline at therapeutic doses. ( Borrás-Blasco, J; Gonzalez-Delgado, M; Navarro-Ruiz, A; Peris-Martí, J; Rosique-Robles, JD; Santos-Calle, FJ, 2000) |
| "To investigate the role of glucocorticosteroid and theophylline in treatment of asthmatic inflammation and their effects in production of nitric oxide (NO) and the expression of inducible nitric oxide synthase (iNOS)." | 3.70 | [The role of glucocorticosteroid and theophylline in asthmatic inflammation of murine model and the inhibition in NO production in lung]. ( Gao, Z; He, Q; Yu, B, 1998) |
| "To validate a previously suggested dosing regimen of aminophylline administration for Thai children, we enrolled 13 asthmatic Thai children (5 girls and 8 boys) between the ages of 7." | 3.69 | Theophylline pharmacokinetics in Thai children. ( Aranyanark, N; Tuchinda, M; Vichyanond, P; Visitsuntorn, N, 1994) |
| " Because leukotrienes are putative mediators of bronchial asthma, the effects of a lipoxygenase inhibitor, VZ564 (N-hydroxy-N-(6-methoxy-3,4-dihydro-2- naphthylmethyl) urea." | 3.69 | Effect of the lipoxygenase inhibitor N-hydroxy-N-(6-methoxy-3,4-dihydro-2-naphthylmethyl)urea on bronchoconstriction and lung vascular permeability in anaphylactic guinea pigs. ( Geist, C; Schneider, J; Zimmer, O, 1995) |
| "A new guinea pig model of allergic asthma was used to investigate the effects of low doses of the phosphodiesterase inhibitors, rolipram (phosphodiesterase IV selective), ORG 20241 (N-hydroxy-4-(3,4-dimethoxyphenyl)-thiazole-2-carboximidamide; dual phosphodiesterase III/IV inhibitor with some selectivity for the phosphodiesterase IV isoenzyme), and of theophylline (non-selective) on allergen-induced early and late phase asthmatic reactions, bronchial hyperreactivity to histamine inhalation, and airway inflammation." | 3.69 | Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs. ( Meurs, H; Olymulder, CG; Santing, RE; Van der Molen, K; Zaagsma, J, 1995) |
| "Chronic administration of theophylline can be used for treating asthma; it may represent a severe risk when some other drugs are prescribed by unaware physicians." | 3.69 | [Status epilepticus in an asthmatic child]. ( Bernard, JL; Bernard, O; Casha, P; Durand, A; Galland, MC; Koné-Paut, I; Pisano, P; Vialet, R, 1994) |
| "Oral theophylline treatment may be helpful in controlling severe asthma during pregnancy." | 3.69 | Slow-release theophylline in pregnant asthmatics. ( Riikonen, S; Stenius-Aarniala, B; Teramo, K, 1995) |
| "This study was undertaken to investigate the effect of theophylline on circulating vitamin B6 levels in children with asthma." | 3.69 | Theophylline attenuates circulating vitamin B6 levels in children with asthma. ( Maeda, S; Mochizuki, H; Morikawa, A; Shimizu, T; Tokuyama, K, 1994) |
| "We retrospectively evaluated three fluent asthmatic children who developed speech dysfluency following administration of theophylline." | 3.69 | Stuttering induced by theophylline. ( McCarthy, M; McKinney, K; Nudelman, HB; Rosenfield, DB; Viswanath, NS, 1994) |
| "We estimated the pharmacokinetic characteristics of theophylline in children with bronchial asthma after multiple oral dosing of Theo-Dur, in order to determine whether the absorption of the drug is best described by a zero-order absorption kinetic model (0-order model) or a first-order absorption kinetic model (1-order model)." | 3.69 | Prediction of steady-state serum theophylline concentration in children by first-order and zero-order absorption models. ( Fukutomi, O; Imaeda, N; Kato, Z; Kondo, N; Orii, T; Yamazaki, M, 1994) |
| "This study was undertaken to investigate the effect of theophylline on serum uric acid levels in children with asthma." | 3.69 | Effect of theophylline on serum uric acid levels in children with asthma. ( Kuroume, T; Maeda, S; Mochizuki, H; Morikawa, A; Shimizu, T; Tokuyama, K, 1994) |
| "To measure specific drug compliance and dosing frequency of two asthma medications, we used medical records data and pharmacy claims data from 276 patients who had concurrent prescriptions for inhaled anti-inflammatory agents and oral theophylline." | 3.69 | Comparison of patients' compliance with prescribed oral and inhaled asthma medications. ( Adlis, SA; Kelloway, JS; Wyatt, RA, 1994) |
| "Theophylline has shown itself to be a useful bronchodilator in the treatment of asthma, although its use has been restricted of late due to its lesser potency and greater side effects when compared with beta-adrenergic inhalants." | 3.69 | [The usefulness of theophylline in the treatment of moderate-severe asthma]. ( Bazo Fernández, E; Cebollero Rivas, P; Colás Sanz, C; Duce Gracia, F; Garisa Rocha, R, 1994) |
| "It may be concluded that combination therapy with inhaled glucocorticoid and sustained release theophylline is a safe and effective form of treatment of mild-to-moderate asthma." | 3.69 | [Successful combination therapy in bronchial asthma. Anti-obstructive and anti-inflammatory treatment]. ( Thomsen, M; Zahn, T, 1994) |
| "Elevated serum levels of theophylline, a first-line anti-asthma drug, are sometimes associated with febrile respiratory infection (FRI)." | 3.69 | [Decreased theophylline clearance in children with acute asthma with concurrent febrile respiratory infection]. ( Asai, T; Ikegami, H; Kurosaki, T; Makino, K; Matsuka, Y; Ohta, F; Saitoh, Y; Tamai, K; Toba, T, 1994) |
| "Hypomagnesaemia in a woman treated with theophylline and albuterol because of recurrent asthmatic attacks prompted us to explore the effects of these drugs on the metabolism of magnesium, calcium, sodium and phosphate in such patients." | 3.69 | Intravenous theophylline-induced excretion of calcium, magnesium and sodium in patients with recurrent asthmatic attacks. ( Bøhmer, T; Falch, J; Knutsen, R, 1994) |
| "Theophylline is widely used by patients with asthma and chronic obstructive pulmonary disease as a bronchodilator." | 3.69 | [Is routine monitoring of theophylline blood levels really effective?]. ( Atsmon, J; Dolev, E; Priel, IE, 1995) |
| "), treated for ten years only by theophylline for bronchial asthma, we observed spontaneous apoptosis of B lymphocytes (10%)." | 3.69 | [In vitro induction of apoptosis in chronic lymphoid leukemia B lymphocytes by theophylline: therapeutic applications]. ( Baudet, S; Binet, JL; Mentz, F; Merle-Béral, H; Ouaaz, F, 1995) |
| "This study was designed to define the predictive value and prevalence of minor symptoms of theophylline toxicity in ambulatory asthmatic adults receiving chronic theophylline therapy with elevated serum theophylline levels." | 3.69 | Minor symptoms are not predictive of elevated theophylline levels in adults on chronic therapy. ( Beaucher, WN; Melamed, J, 1995) |
| " To study the effect of a selective vitamin B-6 deficiency on transsulfuration, we performed oral methionine load tests on 22 vitamin B-6-deficient asthma patients treated with theophylline (a vitamin B-6 antagonist) and 24 age- and sex-matched controls with a normal vitamin B-6 status." | 3.69 | The effect of a subnormal vitamin B-6 status on homocysteine metabolism. ( Allen, RH; Delport, R; Riezler, R; Stabler, SP; Ubbink, JB; van der Merwe, A; Vermaak, WJ, 1996) |
| "The basis for the efficacy of theophylline in the treatment of asthma remains enigmatic." | 3.69 | Anti-inflammatory effects of theophylline: modulation of cytokine production. ( Borish, L; Cvietusa, P; Mascali, JJ; Negri, J, 1996) |
| " A careful review of his medical history and the mechanisms of drug-induced asthma revealed that the etiology of his death was more likely due to heroin abuse and noncardiogenic pulmonary edema." | 3.69 | The role of pharmacology and forensics in the death of an asthmatic. ( Blaho, K; Merigian, K, 1995) |
| "This study was undertaken to investigate the effect of sustained-release theophylline preparations on circulating vitamin B6 concentrations in children with asthma." | 3.69 | [Serum concentrations of the pyridoxal and pyridoxal-5'-phosphate in children during sustained-release theophylline therapy]. ( Fujino, M; Hiraga, Y; Ito, Y; Kobayashi, K; Tanaka, I, 1996) |
| "The practicality, efficacy, and tolerance of a standardized, ready-to-use theophylline solution (Eloasthmin, Leopold Pharma, Graz) was studied on 33 patients with bronchial asthma and/or chronic obstructive bronchitis (COPD) (19 males, 14 females) aged 19 to 79 (median 50) years." | 3.69 | [Practicability, effectiveness and tolerance of a standardized prepared theophylline infusion]. ( Aigner, K; Kummer, F; Lorber, H; Pfeiffer, KP; Pohl, WR; Würtz, J, 1996) |
| " We investigated whether theophylline and beta-agonists were associated with cardiovascular mortality among a cohort of subjects prescribed antiasthma medications." | 3.69 | Bronchodilators and acute cardiac death. ( Blais, L; Ernst, P; Hemmelgarn, B; Suissa, S, 1996) |
| "In the present study, we evaluated the effect of roxithromycin, a semisynthetic macrolide antibiotic, on the cough response to inhaled acetic acid (AA) and on the bronchoconstriction induced by ultrasonically nebulized distilled water (UNDW) in children with asthma." | 3.69 | Roxithromycin attenuates acid-induced cough and water-induced bronchoconstriction in children with asthma. ( Kato, M; Maeda, S; Mochizuki, H; Morikawa, A; Shimizu, T; Takei, K; Tokuyama, K, 1997) |
| "In the UK population studied, salmeterol, ipratropium bromide and theophylline are regularly used to treat patients with asthma of increasing severity." | 3.69 | Drug use and pulmonary death rates in increasingly symptomatic asthma patients in the UK. ( Jick, H; Meier, CR, 1997) |
| "Although first-line therapy for bronchial asthma has changed over the past decade to anti-inflammatory medication such as inhaled corticosteroids and cromolyn with possible addition of beta-agonists, theophylline is still useful and therefore widely used." | 3.69 | [Therapeutic and toxic theophylline levels in asthma attacks--is there a need for additional theophylline?]. ( Fink, G; Fradin, Z; Gardyn, J; Mittelman, M; Zeidman, A, 1997) |
| "4, range: 2-12 years) with an acute asthma attack were treated by an intravenous dosage regimen of theophylline (30 min loading infusion of 6 mg/kg body weight followed by a constant infusion of 1 mg/kg, twice for 6 hr each)." | 3.69 | Disposition of intravenous theophylline in asthmatic children: Bayesian approach vs direct pharmacokinetic calculations. ( el Desoky, E; Ghazal, MH; Klotz, U; Mohamed, MA, 1997) |
| "To evaluate the relationship of psychologic function of severely asthmatic children and families with theophylline compliance during a 1-year follow-up period after inpatient asthma rehabilitation." | 3.69 | Maintaining theophylline compliance/adherence in severely asthmatic children: the role of psychologic functioning of the child and family. ( Faust, D; Weinstein, AG, 1997) |
| "Having observed in recent years that the theophylline dose requirements needed to attain peak serum concentrations of 10 to 20 micrograms/ml infrequently reached previously described mean values, we hypothesized that a downward shift in the range of dose requirements had occurred among patients with asthma." | 3.69 | Apparent decrease in population clearance of theophylline: implications for dosage. ( Asmus, MJ; Hendeles, L; Marshik, P; Milavetz, G; Teresi, ME; Weinberger, MM, 1997) |
| "In a 10-year retrospective observational study the authors investigated the effects of antiinflammatory therapy with corticosteroids (CS), broncholytic therapy with theophylline drugs (TD) and of inhalations of short-action sympathomimetics (ISM) on the course and long-terms outcomes of bronchial asthma (BA)." | 3.69 | [Factors responsible for the course and long-term outcomes of bronchial asthma: chemotherapy]. ( Makolkin, VI; Ovcharenko, SI; Sheianov, MV, 1997) |
| "Theophylline is now considered not only as the a bronchodilatator, but it is increasingly recognised, that it has other anti-asthma activities." | 3.69 | [Selected aspects of theophylline antiinflammatory action on the respiratory tract]. ( Farnik-Brodzińska, M; Pierzchała, W, 1997) |
| "Several lines of evidence support the hypothesis that adenosine contributes to asthma." | 3.69 | Role of adenosine in asthma. ( Biaggioni, I; Feoktistov, I, 1996) |
| " Allergic bronchial eosinophilia in guinea pigs was inhibited by orally administered dexamethasone and methylprednisolone." | 3.68 | Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs. ( Chand, N; De Vine, CL; Diamantis, W; Harrison, JE; Jakubicki, RG; Nolan, KW; Pillar, J; Rooney, SM; Sofia, RD, 1993) |
| "The effect of intravenous theophylline upon the activity of creatinine kinase (CK) and its cardiac specific isoenzyme compound (CK-MB) and the frequency of cardiac arrhythmias was evaluated in 12 patients with bronchial asthma and spastic bronchitis." | 3.68 | [Effect of intravenous infusions of theophylline on cardiac arrhythmias and activity of creatinine kinase CK-MB in patients with airway obstruction]. ( Chazan, R; Droszcz, W; Eneser, M; Karwat, K; Tadeusiak, W; Tymińska, K, 1993) |
| "2 x Postnatal age in weeks) + 5) is preferred when intravenous theophylline therapy for apnea and bradycardia or for asthma is initiated." | 3.68 | Evaluation of three theophylline dosing equations for use in infants up to one year of age. ( Hogue, SL; Phelps, SJ, 1993) |
| "Initiating a course of electroconvulsive therapy (ECT) in patients taking theophylline has been associated with status epilepticus and consequent brain damage or even death." | 3.68 | Electroconvulsive therapy in patients taking theophylline. ( Rasmussen, KG; Zorumski, CF, 1993) |
| "A 32 year old pregnant woman who had taken large doses of theophylline for asthmatic attack was brought to our emergency medical center with convulsion and respiratory disturbance." | 3.68 | [Severe theophylline toxicity in a pregnant asthmatic patient]. ( Kasagawa, J; Nagahama, H; Nagano, K; Seki, I; Suzuki, Y; Yamanaka, I, 1993) |
| "Theophylline, a first-line antiasthma drug, is often associated with severe toxicity even when taken in the recommended schedule." | 3.68 | Are current pediatric dose recommendations for intravenous theophylline appropriate? ( Greenwald, M; Koren, G; Robieux, I; Shear, N; Shilalukey, K; Spino, M, 1993) |
| "We measured urine cotinine levels in 199 children with asthma; 145 also underwent pulmonary-function studies." | 3.68 | Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. ( Chilmonczyk, BA; Haddow, JE; Knight, GJ; Megathlin, KN; Neveux, LM; Palomaki, GE; Pulkkinen, AJ; Salmun, LM, 1993) |
| "Eleven diurnally active asthma patients having a history of nocturnal asthma and treated regularly with albuterol or metaproterenol alone or with twice-daily sustained-release theophylline were evaluated for day-night pattern in peak expiratory flow (PEF) and use of supplemental beta-agonist aerosol for relief of acute asthma." | 3.68 | Day-night variation of airways status in sympathomimetic- and theophylline-treated asthma patients. ( Brown, AC; D'Alonzo, GE; Smolensky, MH, 1993) |
| "Recently, there has been an increasing interest in the involvement of adenosine as a mediator of allergic asthma." | 3.68 | Adenosine-induced bronchoconstriction in an allergic rabbit model: antagonism by theophylline aerosol. ( Ali, S; Metzger, WJ; Mustafa, SJ, 1992) |
| "The effects of theophylline on allergen-induced airway obstruction and bronchial hyperresponsiveness were investigated in allergic rabbits." | 3.68 | Modification of allergen-induced airway obstruction and bronchial hyperresponsiveness in the allergic rabbit by theophylline aerosol. ( Ali, S; Metzger, WJ; Mustafa, SJ, 1992) |
| "We have shown previously that neutrophils (PMNs) from patients with asthma have a more potent stimulated respiratory burst than normals and that their respiratory burst is significantly less suppressed with exposure to 2-chloroadenosine (2-CADO)." | 3.68 | Neutrophils from asthmatics exhibit diminished responsiveness to 2-chloroadenosine which is reversed by theophylline. Evidence for a cyclic-AMP-independent pathway on human neutrophils. ( Borish, L; Joseph, BZ; Sustiel, AM, 1992) |
| "Described is a guinea pig model of allergic asthma, in which animals are sensitized by intraperitoneal injections of ovalbumin complexed with aluminum hydroxide to elicit an IgE response." | 3.68 | Induction by aerosol allergen of sustained and nonspecific IgE-mediated airway hyperreactivity in the guinea pig. ( DeLeo, JJ; Handley, DA; Havill, AM, 1992) |
| "Oral beta-stimulants, theophylline and oral antiallergic drugs are frequently used for asthma treatment in Japan." | 3.68 | [Necessity and limitations of effectiveness of oral beta-stimulants, theophylline and oral antiallergic drugs in asthma treatment]. ( Igarashi, T; Komuta, K; Maeda, K, 1992) |
| "Possible cytogenetic effects of theophylline have been investigated in asthmatic patients undergoing continuous therapy with this drug." | 3.68 | Cytogenetic study in peripheral blood lymphocytes from asthmatic patients receiving continued therapy with theophylline. ( Bernal, ML; Broto, A; Duce, F; Martinez-Berganza, A; Sinues, B; Suarez, MA, 1992) |
| " The serum protein binding of theophylline was studied in 28 asthmatics and 11 patients with cystic fibrosis (CF) who were receiving the drug regularly." | 3.68 | Variability of the serum protein binding of theophylline in patients with asthma and cystic fibrosis. ( Blanchard, J; Harvey, S; Morgan, WJ, 1992) |
| "The clearance of theophylline by hemodialysis was determined in one patient who had polycystic kidney with chronic renal failure and bronchial asthma." | 3.68 | Clearance of theophylline by hemodialysis in one patient with chronic renal failure. ( Chang, DB; Kuo, SH; Luh, KT; Shen, FH; Yang, PC, 1992) |
| "Several reports have been published on the disposition of methotrexate (MTX) when given in low dosages, but none in asthmatic patients." | 3.68 | Pharmacokinetics of low-dose methotrexate in adult asthmatics. ( Cochran, JE; Cott, GR; Erzurum, SC; Glynn-Barnhart, AM; Leff, JA; Martin, RJ; Szefler, SJ, 1992) |
| "A study was made of purine receptors (PR) in healthy subjects and bronchial asthma (BA) patients before and after theophylline (TP) treatment." | 3.68 | [The effect of theophylline on purine receptor function in bronchial asthma patients]. ( Belousov, IuB; Bondareva, GP; Dukhanin, AS; Omel'ianovskiĭ, VV; Sergeev, PV, 1992) |
| "The effect of a clinical pharmacokinetic consultation program for theophylline on the outcomes of pediatric patients with asthma was studied." | 3.68 | Pharmacokinetic consultation program in a pediatric asthma clinic. ( Botha, JH; Miller, R; Tyrannes, I; Wesley, AG, 1992) |
| "Theophylline levels in plasma, erythrocytes and cantharides-induced blister fluid (BF) have been correlated with peak expiratory flow (PEF) in asthmatic patients." | 3.68 | Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients. ( Arnaud, A; Bruguerolle, B; Philip-Joet, F; Reynaud, M, 1992) |
| "Academic achievement among children with asthma, at least those whose status is closely monitored in a structured treatment program, generally appears to be unaffected by asthma or by its treatment with appropriate doses of theophylline." | 3.68 | Does asthma or treatment with theophylline limit children's academic performance? ( Frasher, R; Lindgren, S; Lokshin, B; McCubbin, M; Nassif, E; Stromquist, A; Weinberger, M, 1992) |
| "Theophylline levels in stimulated and unstimulated mixed saliva were compared with total and free (unbound) serum theophylline levels in 11 outpatients with cystic fibrosis (CF) who were using theophylline regularly." | 3.68 | Relationship between serum and saliva theophylline levels in patients with cystic fibrosis. ( Blanchard, J; Harvey, S; Morgan, WJ, 1992) |
| "For the purpose of a safe and effective use of theophylline in therapy during an attack of asthma, we have examined the effect of an attack of bronchial asthma on the metabolism of theophylline." | 3.68 | [Examination of theophylline pharmacokinetics during an attack of bronchial asthma in children]. ( Odajima, Y, 1992) |
| "Seven children from 3 to 14 years old with chronic steroid-dependent asthma were treated with methotrexate (MTX)." | 3.68 | Methotrexate treatment of severe asthma in children. ( Guss, S; Portnoy, J, 1992) |
| "Lipid profiles were determined in three groups of children: children with asthma receiving long-term therapy with slow-releasing theophylline, children with asthma not treated with theophylline, and a control group of children without asthma." | 3.68 | Lipoprotein profile of children with asthma receiving long-term theophylline therapy: a preliminary study. ( Bearman, JE; Shahak, E; Shany, S; Tal, A; Yagupsky, P; Zuili, I, 1992) |
| "The effects of three different dosage schedules for sustained-release theophylline (Theolong) were investigated in children with asthma." | 3.68 | Plasma theophylline concentrations and airway function in asthmatic children receiving standard and modified RTC therapy. ( Arakawa, H; Kato, M; Kimura, T; Kuroume, T; Morikawa, A; Shigeta, M; Tateno, K, 1992) |
| "In order to clarify whether repirinast, an inhibitor of chemical mediator release, could influence the pharmacokinetics of theophylline, a loading test using intravenous injection of aminophylline was performed in 10 subjects with bronchial asthma before and after treatment with 300 mg/day of repirinast." | 3.68 | [The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma]. ( Dohi, Y; Houya, I; Kiuchi, H; Nagata, M; Sakamoto, Y; Tabe, K; Yamamoto, K, 1991) |
| " Theophylline is commonly used to relieve symptoms of chronic asthma." | 3.68 | Theophylline therapy inhibits neutrophil and mononuclear cell chemotaxis from chronic asthmatic children. ( Cambiucci, EC; Condino-Neto, A; De Nucci, G; Guglielmi, AA; Magna, LA; Ribeiro, JD; Vilela, MM, 1991) |
| " Our investigations involve both theoretical arguments and simulation studies, illustrated with data on PK and pharmacodynamic (PD) characteristics of the antiasthma drug theophylline." | 3.68 | The randomized concentration-controlled trial: an evaluation of its sample size efficiency. ( Peck, CC; Sanathanan, LP, 1991) |
| "Theophyllines continue to have a definite place in asthma therapy." | 3.68 | The role of theophyllines in a preventive approach for subjects with both mild and severe asthma. ( Arkinstall, WW, 1991) |
| "Theophylline is used as a prophylactic agent for controlling bronchospasm in patients with asthma." | 3.68 | [A case of sustained-release theophylline (Theodur)-induced asthma]. ( Kitada, O; Kurusu, M; Nakamura, H; Nishioka, Y; Suenaga, N; Sugita, M, 1991) |
| "The steady-state population pharmacokinetics of theophylline were studied in 52 asthmatic adult patients who received sustained-release theophylline as armophylline or euphylline." | 3.68 | Steady-state population pharmacokinetics of sustained release theophylline in adult asthmatic patients. ( Gervais, P; Houze, P; Koen, R; Lagier, G; Thomas, G, 1991) |
| " Theophylline disposition was studied in 70 asthmatic adolescents, ages 8-18 years, to determine if pubertal changes in body size, composition, and organ function are associated with changes in drug disposition." | 3.68 | Theophylline disposition in adolescents with asthma. ( Cary, J; Dell, R; Hein, K, 1991) |
| "Theophylline absorption from two sustained-release theophylline formulations was examined over 2 consecutive days during continuous therapy in 7 asthma patients." | 3.68 | Evaluation of slow-release theophylline pharmacokinetics by Fourier's harmonic analysis. ( Jurcic, B; Lenardic, A; Suskovic, S, 1991) |
| "A retrospective descriptive analysis of 140 asthmatic patients, classified in our hospital as corticosteroid dependent and treated in outpatients departments showed, that 63% received slow release theophylline (SRT)." | 3.68 | [Prednisolone-dependent asthma patients--often under-treated in ambulatory care? Results of a retrospective study]. ( Förster, R, 1991) |
| "Troleandomycin has been reported to be useful for reducing the steroid requirement of patients with asthma." | 3.68 | Use of troleandomycin as a steroid-sparing agent in both asthma and chronic obstructive pulmonary disease. ( Cash, M; Shivaram, U, 1991) |
| "The long-term stability of morning serum theophylline concentrations (STC) and peak expiratory flow (PEF) was investigated for at least one year in 21 asthmatic patients who received individualised theophylline doses in addition to a baseline medication (beta 2-agonists, corticosteroids, anticholinergics by MDI)." | 3.68 | [Long-term stability of morning serum theophylline level in asthma patients under minimally 1-year therapy with Euphylong]. ( Böhm, A; Kunkel, G; Siebert, B; Staudinger, HW; Steinijans, VW, 1991) |
| " The possibility of using saliva and urine was investigated and evaluated in theophylline (Th) therapy, both in asthmatic children and adults." | 3.68 | When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline. ( Agbaba, D; Miljkovic, B; Pokrajac, M; Varagic, VM, 1991) |
| "The effects of prednisolone, salbutamol or theophylline treatment were studied in guinea pigs on bronchial hyperreactivity induced by chronic administration of PAF, (subsequently measuring respiratory flow after an intravenous injection of histamine) and the chemokinesis of leucocytes in vitro." | 3.68 | Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs. ( Berga, P; Fernández, AG; Gristwood, RW; Llupiá, J, 1991) |
| " Urinary excretion of 3-methylhistidine (3-MH) as an index of myofibrillar protein catabolism was measured at the end of a 7-day treatment period with theophylline and a 5-day basal untreated control period in eight patients with stable chronic obstructive pulmonary disease (COPD), eight patients with stable asthma, and eight normal healthy volunteers." | 3.68 | Effect of theophylline on urinary excretion of 3-methylhistidine in patients with lung disease. ( Hoppel, CL; McFadden, ER; Wei, IW, 1991) |
| "Theophylline levels in mixed saliva (both stimulated and unstimulated) were compared with total and free (unbound) serum theophylline levels in 28 asthmatic outpatients using theophylline regularly." | 3.68 | Serum/saliva correlations for theophylline in asthmatics. ( Blanchard, J; Harvey, S; Morgan, WJ, 1991) |
| "Total and free theophylline concentrations were examined by fluorescent immunoassay using serum from 48 asthmatic patients treated with sustained-release theophylline formulation." | 3.68 | [Studies of free theophylline in asthmatic patients]. ( Doi, S; Hattori, H; Hayashida, M; Inoue, T; Kishimoto, S; Takamatsu, I; Toyoshima, K; Yasunami, J, 1991) |
| "The short-term treatment of asthma has for years included supplemental oxygen, IV theophylline, and subcutaneously administered and inhaled beta-adrenergic agonists, anticholinergics, and corticosteroids." | 3.68 | Asthma therapy: present trends and future prospects. ( Mintzer, MJ, 1990) |
| "To examine the effects of serum theophylline concentration on the bronchodilating effect of beta 2-stimulant inhalated by patients with bronchial asthma, 200 micrograms-Salbutamol inhalation test was performed on 30 patients with bronchial asthma (from 17 to 71 years old, averaging 49." | 3.68 | [The influence of serum theophylline concentration on the bronchodilating effect of salbutamol inhalation for bronchial asthma]. ( Hashimoto, T; Kondo, A; Nakamata, M; Tsukioka, K, 1990) |
| " Inhaled beta-agonists were the most commonly prescribed antiasthmatic agents in 1986, followed by sustained-release theophylline and inhaled corticosteroids." | 3.68 | Use of antiasthmatic drugs in Australia. ( Bowes, G; Hurley, SF; Jenkins, MA; McNeil, JJ, 1990) |
| "The dependence of the renal excretion of theophylline on its plasma concentration and urine flow rate has been investigated in asthmatic children of either sex." | 3.68 | Dependence of the renal excretion of theophylline on its plasma concentrations and urine flow rate in asthmatic children. ( Agbaba, D; Pesić, V; Pokrajac, M; Varagić, VM, 1990) |
| "Tracheal smooth muscle from seven cases of fatal asthma demonstrated an increased contractile response to histamine, acetylcholine, and electrical stimulation of intrinsic cholinergic nerves; impaired relaxation to isoproterenol, and possibly theophylline, was also evident (1)." | 3.68 | Abnormalities in airway smooth muscle in fatal asthma. A comparison between trachea and bronchus. ( Bai, TR, 1991) |
| "We studied the steroid-sparing effect of dapsone in 10 subjects with chronic asthma in a preliminary open trial." | 3.68 | The effect of dapsone in steroid-dependent asthma. ( Berlow, BA; Dyer, Z; Liebhaber, MI; Spiegel, TM, 1991) |
| "In order to investigate the mechanism of adenosine-induced bronchoconstriction in asthma, serum neutrophil chemotactic activity (NCA) was measured in normal individuals and patients with asthma before and 5 min after bronchoprovocation testing with adenosine." | 3.68 | Bronchial challenge with adenosine causes the release of serum neutrophil chemotactic factor in asthma. ( Driver, AG; Kukoly, CA; Metzger, WJ; Mustafa, SJ, 1991) |
| "to determine the relation of serum theophylline concentrations (STC) to the occurrence of cardiac arrhythmias in a population of hospitalized patients." | 3.68 | The arrhythmogenicity of theophylline. A multivariate analysis of clinical determinants. ( Bittar, G; Friedman, HS, 1991) |
| "We studied the role of theophylline on outcome of status epilepticus (SE) in children." | 3.68 | Theophylline and status epilepticus in children. ( Dunn, DW; Parekh, HU, 1991) |
| "Two aged patients with bronchial asthma and chronic obstructive pulmonary disease who suffered convulsions that resulted in permanent brain damage during treatment with the recommended therapeutic dose of theophylline are presented here." | 3.68 | Permanent brain damage possibly caused by theophylline in two elderly patients with airway obstruction. ( Aikawa, T; Fukushima, T; Itabashi, S; Sasaki, H; Sekizawa, K; Yanai, M, 1990) |
| "This study examined the relationship between long-term theophylline therapy and behavior problems in 14 asthmatic children that includes 5 intractable cases and 24 non-asthmatic children." | 3.68 | [Clinical effects of theophylline in the therapy of intractable asthmatic children. II. Theophylline therapy and behavior problems in children with asthma]. ( Iikura, Y; Segawa, H, 1990) |
| "We have tested the possibility of replacing plasma assays by salivary assays of theophylline for the monitoring of sustained-release theophylline therapy in asthmatic children." | 3.68 | [Treatment with sustained theophylline release. Monitoring by salivary assay in children]. ( Aergerter, P; Bidat, E; Flouvat, B; Gallet, JP; Leneveu, A; Roux, A, 1990) |
| "The effect of menstrual cycle on the pharmacokinetics of theophylline has been studied in 9 female asthmatic patients." | 3.68 | Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics. ( Bruguerolle, B; Faraj, F; Razzouk, H; Toumi, M; Vervloet, D, 1990) |
| "In the treatment of bronchial asthma, usefulness of beta 2-agonists aerosol inhalation are emphasized as well as sustained theophylline tablets recently." | 3.68 | [Inhalation therapy for bronchial asthma. A. Bronchodilator--beta 2-stimulant]. ( Awaya, M; Satake, T; Takagi, K; Yamaki, K, 1990) |
| "Unstimulated saliva, citric acid stimulated saliva, and serum were collected from 31 asthmatic children taking theophylline." | 3.68 | Comparison of unbound and total serum theophylline concentrations with those of stimulated and unstimulated saliva in asthmatic children. ( Ben-Aryeh, H; Colin, AA; Gozal, D; Laufer, D; Siegel, IA; Szargel, R, 1990) |
| "We report a case of fatal theophylline overdose in a 16-year-old asthmatic boy who presented with seizures, respiratory arrest, and a theophylline concentration of 117 mg/L in serum." | 3.68 | Massive theophylline overdose with atypical metabolic abnormalities. ( Eshleman, SH; Shaw, LM, 1990) |
| "Women in the Collaborative Perinatal Project who received theophylline during pregnancy were no more likely to be delivered of a stillborn infant than were women who did not receive theophylline." | 3.68 | Maternal theophylline consumption and the risk of stillbirth. ( Leviton, A; Neff, RK, 1990) |
| "The effect of ozagrel (OKY-046), a selective thromboxane A2 synthetase inhibitor, on theophylline disposition was studied in 12 asthmatic patients." | 3.68 | Effect of ozagrel (OKY-046), a thromboxane synthetase inhibitor, on theophylline pharmacokinetics in asthmatic patients. ( Kawaguchi, H; Kawakatsu, K; Kino, T; Oshima, S; Satake, N; Tsubata, R; Yasuba, H, 1990) |
| "The effect of an oral anti-allergic drug, mequitazine, on the pharmacokinetics of theophylline has been investigated in seven asthmatic patients." | 3.68 | Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients. ( Apichartpichean, R; Hasegawa, T; Kuzuya, T; Muraoka, I; Nadai, M; Takagi, K, 1990) |
| "The serum theophylline concentration was determined in 150 asthmatic patients who received treatment from General Practitioners in the Exeter Health District." | 3.68 | General practice theophylline audit in the Exeter Health District. ( Capps, N; Jordan, P; Sewell, GJ; Watkins, K, 1990) |
| "In 86 asthmatic children, the theophylline levels in the serum and saliva were compared." | 3.68 | [Comparison of salivary with serum levels of retard theophylline under steady-state conditions]. ( Mansfeld, J; Schmitz-Schumann, M; Virchow, C, 1990) |
| "The bio-availability of two slow-release theophylline capsules employing different sustained-release principles, was investigated in 12 children suffering from bronchial asthma, on this basis of the renal excretion of the unchanged active substance." | 3.68 | [Bioequivalence of theophylline retard capsules in children and relation of metabolism to administration route]. ( Berdel, D; Bonnacker, I; Buhr, W; Süverkrüp, R; von Berg, A, 1990) |
| "The clinical efficacy of the new Soviet long-acting drug theophylline (theopec) was studied in 126 patients with bronchial asthma and chronic obstructive bronchitis." | 3.68 | [The efficacy of theopek in bronchial asthma and chronic bronchitis]. ( Korzh, OB, 1990) |
| "Sustained-release theophylline (SRT) therapy was monitored in ambulatory children with asthma by measuring theophylline in citric acid-stimulated saliva." | 3.68 | Variations in theophylline concentrations detected by 24-hour saliva concentration profiles in ambulatory children with asthma. ( Aviram, M; Gorodischer, R; Tal, A, 1990) |
| "Our study was designed to assess potential cardiovascular adverse effects in clinically stable asthmatic children due either to oral sustained-release theophylline or theophylline in combination with an inhaled beta-2 adrenergic agonist." | 3.68 | Lack of adverse cardiac effects of combined treatment with theophylline and albuterol in asthmatic children. ( Bastianon, V; Bernardini, L; Businco, L; Coletta, F; Colloridi, V; Di Fazio, A; Ferrucci, A; Marzano, MC; Pucci, S; Sorbara, N, 1990) |
| "Theophylline binding to plasma protein was studied with seven bronchial asthmatic inpatients." | 3.67 | Clinical evaluation of theophylline binding to plasma protein in bronchial asthmatic patients. ( Hasegawa, M; Hasegawa, T; Johno, I; Kitazawa, S; Ogura, Y; Satake, T; Takagi, K; Yokochi, Y, 1984) |
| "Serum theophylline clearance was estimated prior to reaching steady state in 29 asthmatic children, aged 1-14 years, using methods described by Chiou et al." | 3.67 | Rapid estimation of serum theophylline clearance in children with acute asthma. ( Brown, AL; Kearns, GL; Kluza, RB; McConnell, RF; Stillwell, PC; Trang, JM; Wells, TG, 1984) |
| "The efficacy of microcrystalline theophylline is examined in patients with stabilized bronchial asthma." | 3.67 | [Possibilities for optimizing therapy with theophylline preparations. Clinical effectiveness and side effects of microcrystalline theophylline]. ( Iwainsky, H; Sehrt, I; Wiesner, B, 1984) |
| "Drug intake and plasma concentrations of theophylline and beta-agonists were recorded in 19 patients with acute asthma (peak expiratory flow rate less than 50% of predicted normal value and heart rate greater than 100 beats/min)." | 3.67 | Drug intake and plasma concentrations in acute asthma. ( Boe, J; Ljungholm, K, 1984) |
| "Assessment of individual pharmacokinetics has been helpful in the evaluation of patients with persistently low serum theophylline concentrations and poorly controlled asthma." | 3.67 | Use of pharmacokinetic profile in evaluating patients with repeatedly low theophylline concentrations. ( Baswell, B; Georgitis, JW; Shen, DD; Szefler, SJ, 1984) |
| "Twenty four hour profiles of serum theophylline concentrations were examined in 15 asthmatic children taking a new theophylline preparation once a day." | 3.67 | Once a day theophylline; serum concentrations. ( McKenzie, SA; Nerminathan, V, 1984) |
| "The pharmacokinetic profiles of three oral sustained-release theophylline preparations in steady state (350 mg Theograd, 350 mg Theolair Retard [= Nuelin Retard], and 300 mg Theolin Retard [= Theodur]) were compared in a group of six normal subjects and six patients with moderately severe asthmatic bronchitis." | 3.67 | Pharmacokinetics and pharmacodynamics of three sustained-release theophylline preparations (350 mg Theograd, 350 mg Theolair Retard and 300 mg Theodur) in steady state in healthy volunteers and asthmatics--Part I: Theophylline plasma levels. ( Drost, RH; Kreukniet, J; Maes, RA; van der Vet, AP, 1984) |
| "The pharmacokinetics of theophylline and methylprednisolone were examined before and during cimetidine treatment in an asthmatic woman who required long-term administration of these drugs." | 3.67 | Cimetidine-methylprednisolone-theophylline metabolic interaction. ( Ebling, WF; Gardner, MJ; Green, AW; Jusko, WJ, 1984) |
| "Twenty-seven asymptomatic asthmatic children with airway obstruction received a single oral dose of one out of three solutions, in a double-blind, randomized fashion, containing: etamiphylline, 6." | 3.67 | [Comparative study of the effect of a single oral dose of theophylline and etamiphyllin in children with asthma]. ( Labayru, MT; Vázquez, C, 1984) |
| "Ten patients with exacerbated chronic asthmatic bronchitis, subdivided into two groups on the basis of respiratory failure, were treated with theophylline-ethylendiamine administered by continuous venous infusion (0." | 3.67 | Macrolide antibiotics and serum theophylline levels in relation to the severity of respiratory impairment: a comparison between the effects of erythromycin and josamycin. ( Bartolucci, L; Gradoli, C; Iapadre, M; Valori, C; Vincenzi, V, 1984) |
| "The bronchodilating effect and side-effects of theophylline and a beta 2-adrenoceptor stimulating drug (terbutaline) alone and in combination were studied in 10 adult asthmatic patients." | 3.67 | Simultaneous treatment with terbutaline and theophylline. ( Billing, B; Dahlqvist, R; Garle, M; Hörnblad, Y; Ripe, E, 1984) |
| "On the assumption that plasma unbound drug concentrations are therapeutically active, the value of saliva concentrations in predicting plasma unbound theophylline concentrations was investigated in 25 ambulatory adults (aged 27 to 84 years) receiving theophylline (225-1350 mg aminophylline daily) for asthma or chronic bronchitis." | 3.67 | Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined. ( Bateman, M; Knott, C; Reynolds, F, 1984) |
| "A 61 year-old male patient developed gynecomastia after starting theophylline." | 3.67 | Gynecomastia associated with theophylline. ( Dardick, KR, 1984) |
| "To investigate serum theophylline levels during acute attacks of asthma, venous blood samples were taken from 41 consecutive patients." | 3.67 | Serum theophylline during acute asthmatic attacks. ( Tønnesen, J, 1984) |
| "We compared the bronchodilator effects and pharmacokinetics of orally administered caffeine (10 mg per kilogram of body weight) and theophylline (5 mg per kilogram) in a double-blind, single-dose study in asthmatic patients 8 to 18 years of age." | 3.67 | The bronchodilator effects and pharmacokinetics of caffeine in asthma. ( Becker, AB; Gillespie, CA; Simons, FE; Simons, KJ, 1984) |
| "To determine whether asthma alone can cause irreversible airflow obstruction 42 men and 47 women with chronic asthma (mean duration 22 (SD 13) years) without evidence of other disease likely to cause irreversible airflow obstruction were treated with theophylline orally and a beta agonist both orally and by inhalation for four weeks." | 3.67 | Asthma and irreversible airflow obstruction. ( Brown, PJ; Finucane, KE; Greville, HW, 1984) |
| "As theophylline is known to stimulate lipolysis and lipid mobilisation, plasma concentrations of malonyl dialdehyde were studied in asthmatic patients being treated with sustained release theophylline." | 3.67 | Long term treatment with theophylline increases malonyl dialdehyde plasma concentrations. ( Bensadoun, J; Chaintreuil, J; de Paulet, AC; Godard, P; Michel, FB; Parelon, G, 1984) |
| "Inhaled adenosine causes bronchoconstriction in asthmatic patients." | 3.67 | Adenosine-induced bronchoconstriction in asthma. Antagonism by inhaled theophylline. ( Cushley, MJ; Holgate, ST; Tattersfield, AE, 1984) |
| "Aggressive pharmacotherapy for the treatment of patients with severe status asthmaticus includes theophylline and beta-adrenergic agonists such as isoproterenol." | 3.67 | Effect of isoproterenol on measured theophylline levels. ( Crone, RK; O'Rourke, PP, 1984) |
| "In a double-blind cross-over study, including double-dummy placebo, 8 adult asthmatics received oral sustained-release proxyphylline 900 mg (Neofyllin retard) twice daily, or 250 mg microcrystalline theophylline (Nuelin) 4 times daily for 6 days." | 3.67 | Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. ( Madsen, L; Rasmussen, FV; Waldorff, S, 1984) |
| "In the treatment of obstructive lung diseases theophylline is one of the most important drugs." | 3.67 | [Possibilities for optimizing therapy with theophylline preparations. I. On the pharmacokinetics of theophylline preparations]. ( Iwainsky, H; Sehrt, I; Wiesner, B, 1984) |
| "The purpose of the study were to investigate the cardiopulmonary adaptations of asthmatic children to physical exercise and to evaluate the effects of theophylline." | 3.67 | Cardiopulmonary responses of asthmatic children to strenuous exercise. Effect of theophylline. ( Chryssanthopoulos, C; Gallen, WG; Hause, LL; Maksud, MG, 1984) |
| "Theophylline has long been a cornerstone of bronchodilator therapy for asthma and chronic obstructive lung disease, but until recently its use carried the risk of serious, even fatal, toxicity." | 3.67 | Theophylline therapy. Titrating dosage requirements. ( Uden, DL; Wyatt, RA; Zaske, DE, 1984) |
| "We report on two female patients, aged 22 and 50 receiving high-dose theophylline, 750-1,500 mg/day, for bronchial asthma, who were admitted to hospital with severe grand-mal seizures, in one primary focal with secondary generalisation." | 3.67 | [Grand mal series and status using high-dose theophylline medication]. ( Hager, H; Pohlmann-Eden, B, 1989) |
| " The infection coincided with neutropenia resulting from pyrazolone treatment." | 3.67 | Trichosporon beigelii pneumonia in a neutropenic patient. ( Borras, R; Chiner, E; Franco, J; Marin, J, 1989) |
| " The autoradiographic distribution of alpha 1-adrenoceptors was investigated in non-diseased and asthmatic human lung by use of [3H]-prazosin (H-PZ)." | 3.67 | Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung. ( Goldie, RG; Paterson, JW; Rigby, PJ; Spina, D, 1989) |
| "A possible pharmacokinetic interaction between theophylline and repirinast has been investigated in asthmatic patients." | 3.67 | Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients. ( Apichartpichean, R; Hasegawa, T; Horiuchi, T; Kuzuya, T; Nadai, M; Ogura, Y; Takagi, K, 1989) |
| "We report a case of respiratory arrest in a ten-year-old asthmatic girl under beta-2-agonists and theophylline." | 3.67 | [Respiratory arrest in an asthmatic girl treated with beta-2-mimetics and theophylline. Possible role of hypokalemia in sudden death in asthmatic patients]. ( Benhamou, PH; Devoldere, C; Epelbaum, S; Kremp, O; Pautard, JC; Piussan, C, 1989) |
| "Aminophylline administration was compared in 43 patients who died from asthma and 43 matched controls who were admitted, suffering from acute asthma, to hospitals in the North East Thames Region." | 3.67 | Aminophylline toxicity--how many hospital asthma deaths does it cause? ( Eason, J; Markowe, HL, 1989) |
| "Theophylline serum levels were studied after oral administration of slow release theophylline (Talofilina) in children with bronchial asthma." | 3.67 | Theophylline serum levels in children with bronchial asthma after administration of slow release theophylline as open or closed capsules. ( Naspitz, CK; Solé, D, 1989) |
| "Subjects suffering from bronchial asthma being treated with theophylline often have to be treated with an antibiotic during acute stages." | 3.67 | [Macrolide-theophylline interaction. Experiences in pediatrics]. ( Girardo, G; Leone, L; Mora, P; Moresco, V; Pavesio, D, 1989) |
| "The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children." | 3.67 | Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. ( Garg, SK; Kumar, L; Lal, R; Shukla, VK; Singh, S, 1989) |
| "In 28 children suffering from asthma--20 boys and 8 girls aged 3-19 years, weighing 18-79 kg--theophylline concentrations in serum and saliva were assessed." | 3.67 | [Monitoring serum theophylline levels in children. Use of saliva for prediction]. ( Dolezalová, K; Etlerová, E; Kopecká, J; Kuralová, Z; Martínková, J, 1989) |
| "Pharmacodynamic and pharmacokinetic properties of sustained-release anyhdrous theophylline (Theolair-SR) were similar when doses were given either immediately after or two hours after low-fat meals in children with moderate asthma requiring daily theophylline maintenance." | 3.67 | Pharmacokinetic properties of sustained-release theophylline (Theolair-SR) in relation to timing of doses after low-fat meals. ( Harrison, LI; Kvam, DC; McCarville, SE; Moyer, TP; O'Connell, EJ; Sachs, MI; Welsh, PW; Wick, KA, 1989) |
| "The bronchodilating effect of theophylline was studied from the perspective of its influence on the severity of acute asthmatic attack and where its acting site is located on bronchi." | 3.67 | Effect of theophylline on improvement of the pulmonary function in the treatment of acute episodes of asthma: the influence of the severity of acute asthma. ( Horai, Y; Kabe, J; Sakamoto, Y, 1989) |
| "Monitoring of theophyllinaemia in the course of 24 h during treatment with theophylline anhydrate capsules (Euphyllin CR) was used in 20 children (9-15 years) and in 20 adults (18-61 years) with bronchial asthma." | 3.67 | [Pharmacokinetics and chronotherapy of delayed action theophylline (Euphyllin CR)]. ( Pohunek, P; Reisová, M; Spicák, V; Tomíska, F; Trnavská, Z; Vondra, V, 1989) |
| "In 27 cases of acute severe asthma, a loading dose of 5 mg/kg of aminophylline (omitted if already receiving oral theophylline) followed by a continuous infusion of 1 mg/kg per hour gave satisfactory theophylline levels at 4 h and 24 h." | 3.67 | Aminophylline dosage in acute severe asthma. ( Gleeson, JG; Price, JF, 1989) |
| "The reliability and predictive value of salivary theophylline levels was investigated in 58 children who were treated with oral sustained-release theophylline preparations for bronchial asthma." | 3.67 | Monitoring theophylline levels in serum and saliva using fluorescence polarization immunoassay and Seralyzer. ( Berdel, D; Buhr, W; Schmidt, M; Schulte, T; Walkenbach, A, 1989) |
| "A 9-year-old boy developed Stevens-Johnson syndrome after taking slow-release theophylline for bronchial asthma." | 3.67 | Development of severe Stevens-Johnson syndrome after administration of slow-release theophylline. ( Brook, U; Fried, D; Singer, L, 1989) |
| "The pharmacokinetics of theophylline in serum and saliva, and the pulmonary functions were examined in seven asthmatic children aged 9-14 years in both single (6." | 3.67 | [Pharmacokinetics and pharmacodynamics of sustained-release theophylline formulation, Slo-bid, in both single and multiple dosing studies of asthmatic children]. ( Baba, M; Iwasaki, E, 1989) |
| "We often see severe asthma attacks occur in patients taking high doses of theophylline and disappear soon after intravenous injection of aminophylline." | 3.67 | [Asthma patients requiring unusually high doses of theophylline]. ( Matsumura, Y; Nakamura, T; Otsuka, H; Shiga, M; Sugiyama, H; Tomoe, Y, 1989) |
| "Clinicians frequently rely on serum theophylline concentrations (STCs) as an indicator of compliance for asthma medications." | 3.67 | Are theophylline "levels" a reliable indicator of compliance? ( Hill, M; Kossoy, AF; Lin, FL; Szefler, SJ, 1989) |
| "Plasma theophylline levels (mcg/ml) of 93 patients with a bronchopulmonary disease (asthma and chronic obstructive lung disease) who were on theophylline (normal or retarded) treatment, were determined on admission at the emergency ward because of acute bronchospasm." | 3.67 | [Levels of blood theophylline in patients with acute bronchospasm]. ( García Delgado, R; García Morillas, M; Martínez, B; Martínez, MJ; Puche, E; Saucedo, R, 1989) |
| "Theophylline, despite its potential for causing gastrointestinal tract and central nervous system side effects, is still the major drug used to control symptoms of moderate asthma in children." | 3.67 | Theophylline: is it obsolete for asthma? ( Rooklin, A, 1989) |
| "We monitored 14 asthmatic subjects (aged 18 to 60 years), with multiple 24-hour electrocardiogram (Holter) recordings, who were taking continuous sustained-release theophylline and beta-2-adrenergic therapy for control of their symptoms." | 3.67 | Lack of significant arrhythmogenicity from chronic theophylline and beta-2-adrenergic combination therapy in asthmatic subjects. ( Kelly, HW; Menendez, R; Voyles, W, 1985) |
| "Four critical issues related to theophylline are addressed: What is theophylline? Why use it? How should it be used? Who should receive it? Theophylline is a methylated xanthine with established clinical benefit as maintenance therapy for chronic asthma." | 3.67 | Theophylline use: an overview. ( Hendeles, L; Weinberger, M, 1985) |
| "Serum theophylline levels were measured in response to a single daily dose of Uniphyl in asthmatic adults who had previously received sustained-release theophylline preparations (usually Theo-Dur)." | 3.67 | Theophylline levels and clinical response in asthmatic adults receiving long-term Uniphyl. ( Petty, TL; Rollins, DL, 1985) |
| "It is widely believed that theophylline is a valuable addition to beta-agonists in the treatment of asthma." | 3.67 | Aminophylline in acute asthma. ( Olson, LG, 1987) |
| "The rate of ethanol elimination and blood acetate concentrations after a peroral dose of alcohol were measured in eight asthmatic patients receiving high-dose corticosteroid, sustained release theophylline and beta-2-sympathicomimetic treatment and in eight nonalcoholic, healthy controls." | 3.67 | Increased rate of ethanol elimination and elevated blood acetate in asthmatics on corticosteroid, beta-2-sympathicomimetic and theophylline treatment. ( Korri, UM; Salaspuro, M, 1988) |
| " To determine the clinical relevance of this potential interaction in patients with chronic asthma, we measured a peak steady-state theophylline serum concentration in 21 subjects while receiving theophylline alone (400 to 1,500 mg/day), and again, at least seven days later, after the addition of continuous therapy with maximally tolerated doses of either diltiazem (n = 18) or nifedipine (n = 16)." | 3.67 | Clinical relevance of the interaction of theophylline with diltiazem or nifedipine. ( Christopher, MA; Harman, E; Hendeles, L, 1989) |
| "Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured." | 3.67 | The relationship between theophylline clearance and age in adult life. ( Jackson, SH; Johnston, A; Turner, P; Woollard, R, 1989) |
| "Twelve children with chronic asthma were treated with a single dose of sustained-release theophylline once-a-day taken after supper at 9 PM." | 3.67 | Theophylline levels after single daily and divided dosing of a once-a-day theophylline preparation in asthmatic children. ( Boner, AL; Messori, A; Plebani, M; Sette, L; Vallone, G, 1989) |
| "Extrinsic asthmatic patients have been reported to have a deficiency of concanavalin A (Con A)-induced suppressor cell function." | 3.67 | Effect of in vitro colchicine and oral theophylline on suppressor cell function of asthmatic patients. ( Feierman, E; Ilfeld, D; Kivity, S; Kuperman, O; Topilsky, M, 1985) |
| "T-cell subpopulations and their function were studied in asthmatic children with or without theophylline therapy." | 3.67 | Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children. ( Colin, AA; Horenstien, L; Lahat, N; Nir, E, 1985) |
| "Fifty-four episodes of hypercapnic status asthmaticus (Pa CO2 50 mmHg or more) were treated with intravenous theophylline (6 mg/kg over 30 minutes, then 1 mg/kg/hour), intravenous hydrocortisone hemisuccinate (1 g then 500 mg 4-hourly) rehydration and oxygen therapy at a sufficient rate to obtain a Pa O2 of 80 mmHg or more." | 3.67 | [Hypercapnic status asthmaticus. Rapid reversibility of hypercapnia under medical treatment]. ( Boissinot, E; Ginies, G; Perrotin, D, 1986) |
| "Twenty patients with bronchial asthma, on long-term oral therapy with theophylline, demonstrated an increased number of suppressor T-cells and impaired graft vs host reaction." | 3.67 | Theophylline-induced alterations in cellular immunity in asthmatic patients. ( Fink, G; Mittelman, M; Shohat, B; Spitzer, SA, 1987) |
| "A group of 10 patients with chronic asthmatic bronchitis was titrated with slow-release theophylline (Theolin Retard) to a steady state plasma theophylline level of 10 mg/l." | 3.67 | Pharmacodynamics (lung function tests, tremor measurements and cAMP determinations) of a single dose of 0.5 mg terbutaline subcutaneously during sustained-release theophylline medication in patients with asthmatic bronchitis. ( Drost, RH; Fokkens, JK; Hamelink, ML; Kreukniet, J; Maes, RA; van der Vet, AP, 1986) |
| "Five asthmatic children (2 to 5 years) with persistent crying-induced bronchospasm refractory to concomitant oral theophylline and metaproterenol for 4 weeks were selected for an 8-week uncontrolled study with nebulized metaproterenol 5% and sodium cromoglycate 1%." | 3.67 | Crying-induced bronchospasm in childhood asthma: response to nebulized metaproterenol 5% and sodium cromoglycate 1%. ( Weinstein, AG, 1986) |
| "We developed an individualized approach for determining the intravenous rate of theophylline infusion for the treatment of status asthmaticus in children." | 3.67 | The use of theophylline clearance in pediatric status asthmaticus. II. The choice of appropriate dose for the intravenous theophylline infusion. ( Kolski, GB; Levy, J, 1987) |
| "The volume of distribution (Vd) of theophylline and the relevant aminophylline loading dose (LD) are usually calculated on the basis of total body weight (TBW)." | 3.67 | Effect of body weight on the volume of distribution of theophylline. ( Bonanno, A; Mirabella, A; Rizzo, A, 1988) |
| "Induction of theophylline-sensitive T-suppressor cells with THF, a thymic hormone, resulted in elevation of the low levels of these lymphocytes in non-treated asthmatic children." | 3.67 | Modulation of T-cell subsets in asthmatic children by THF, a thymic hormone. ( Shohat, B; Trainin, N; Varsano, I; Volovitz, B, 1985) |
| "Ambulant continuous intravenous theophylline therapy was used in a patient with frequent and severe asthmatic attacks." | 3.67 | Continuous intravenous therapy with theophylline in a patient with brittle bronchial asthma. ( Speelberg, B; van den Brink, WT, 1988) |
| "A pharmacokinetic model was applied to achieve therapeutic serum theophylline concentrations rapidly in 25 children with status asthmaticus." | 3.67 | Prediction of intravenous theophylline dosage based on a single, nonsteady-state concentration: a clinical study of childhood status asthmaticus. ( Anderson, DA; Kurland, G; Marquardt, ED; Mitsuoka, JC, 1988) |
| "A total of 42 children, aged from 5 to 13, all having been diagnosed as extrinsic asthma cases, were observed with the aim of establishing the average dose needed to maintain serum concentration by means of the administration of a slow-release theophylline preparation." | 3.67 | [Slow-release theophyllines: serum and saliva levels in asthmatic children]. ( Alvarez Sanz, E; Díaz Gómez, MI; Duque Hernández, J; Galván Tudela, L; Souto Martínez, I, 1988) |
| "The aim of the study was to determine whether gastro-oesophageal (GO)-reflux was increased by normal maintenance doses of theophylline, and if so, whether this was detrimental to lung function in asthmatic patients with symptoms of reflux." | 3.67 | Influence of theophylline on gastro-oesophageal reflux and asthma. ( Ekström, T; Tibbling, L, 1988) |
| "This study assessed the potential clinical benefit of rapid theophylline assays in an urban pediatric emergency department by 1) examining current practices of monitoring and adjusting theophylline therapy in children with asthma and 2) determining the relationship between these practices and the adequacy of theophylline therapy and duration of emergency department visits." | 3.67 | Serum theophylline testing in a pediatric emergency setting: potential benefit of rapid assays. ( Fleisher, GR; Schwartz, JS; Shaw, KN, 1988) |
| "Filter paper cards incorporating dried blood spots for the measurement of theophylline concentrations were returned by 62 out of 100 asthmatic children sent kits with instructions for their collection." | 3.67 | Acceptance of domiciliary theophylline monitoring using dried blood spots. ( Rattenbury, JM; Tsanakas, J, 1988) |
| "Theophylline absorption was studied in asthmatic children ages 2-7 years." | 3.67 | The consistency of theophylline absorption from a sustained-release formulation in asthmatic children. ( Haltom, JR; Hill, M; Szefler, SJ, 1988) |
| "Study of the impact of rapid availability of theophylline concentrations on emergency treatment of acute asthma disclosed use of AccuLevel in 50 children significantly shortened the time required to reach concentrations of at least 10 micrograms/mL and shortened time spent in the emergency room as compared with 50 children in whom serum concentrations were measured only by EMIT." | 3.67 | Impact of AccuLevel on treatment of acute asthma. ( Altieri, MF; Boeckx, RL; Klein, BL; Mattey, JE; Nguyen, QC; Ochsenschlager, DW; Shier, JM; Sly, RM, 1988) |
| "To study whether theophylline inhibits airway hyperresponsiveness in a dose-dependent fashion, we performed inhalation challenges with histamine and methacholine in 9 asthmatic patients." | 3.67 | Theophylline has a dose-related effect on the airway response to inhaled histamine and methacholine in asthmatics. ( Jörres, R; Magnussen, H; Reuss, G, 1987) |
| "Fifteen Chinese subjects with stable asthma were given asymmetric doses of slow-release choline theophyllinate (Theobret) according to body weight; patients under 60 kg (132 lb) received 180 mg at 9 AM and 360 mg at 9 PM for six days (period 1), followed by 180 mg at 1 PM and 360 mg at 9 PM for six days (period 2); for those over 60 kg, the regimen was the same, except that they received 270 mg during the daytime and 540 mg at night." | 3.67 | The pharmacokinetics and efficacy of slow-release theophylline with asymmetric dosing in asthmatic Chinese. ( Pang, JA; Swaminathan, R; Zhang, YG, 1988) |
| "Co-administration of intravenous albuterol and theophylline resulted in increased theophylline clearance in a child with severe asthma." | 3.67 | Enhancement of theophylline clearance by intravenous albuterol. ( Amirav, I; Amitai, Y; Avital, A; Godfrey, S, 1988) |
| "Theophylline not only is a bronchodilator but also has other effects (inhibition of mediator release, enhancement of mucociliary clearance, enhancement of diaphragmatic contractility) that are potentially beneficial to asthmatic patients." | 3.67 | How much theophylline is enough? ( Fairshter, RD, 1988) |
| "To explore the possibility that theophylline may act through adrenomedullary secretion of catecholamines, we examined the time courses of plasma norepinephrine (NE), epinephrine (E), and theophylline concentrations and peak expiratory flow (PEF) in nine children with an acute exacerbation of asthma receiving a 72-hour constant infusion of aminophylline." | 3.67 | Plasma catecholamine concentrations during a 72-hour aminophylline infusion in children with acute asthma. ( Ishizaki, T; Kanagawa, S; Minegishi, A; Morishita, M; Nagai, T; Odajima, Y; Yamaguchi, M, 1988) |
| "The purpose of this study was to evaluate prospectively the occurrence of cardiac arrhythmias during the combined therapy with intravenous aminophylline and terbutaline in 29 consecutive patients with status asthmaticus." | 3.67 | Cardiac arrhythmias during the combined use of intravenous aminophylline and terbutaline in status asthmaticus. ( Chauvet, JP; Iung, B; Laaban, JP; Proteau, J; Psychoyos, I; Rochemaure, J, 1988) |
| " The free and total plasma and saliva concentrations of theophylline were measured during a dosing interval at steady state in nineteen asthmatic subjects receiving a once-daily theophylline preparation (Riker TCR-1)." | 3.67 | Determinants of free theophylline clearance in asthma. ( Alwazir, YA; Buss, DC; Campbell, IA; John, R; Lazarus, JH; Littley, M; Routledge, PA; Williams, PE, 1987) |
| "The pharmacokinetic and clinical efficacy of three theophylline slow-release formulations was studied in 29 children suffering chronic bronchial asthma." | 3.67 | [Monitoring of three delayed-release preparations of theophylline in the plasma of children: pharmacokinetic parameters and therapeutic significance]. ( Domínguez Granados, R; Girón Caro, F; Gómez Rubio, M; Molina Font, JA; Pita Calandre, E, 1987) |
| "Pharmacokinetic studies of theophylline were carried out in 12 Thai asthmatic children after oral administration of Elixir Quibron and Tablet Aminophylline." | 3.67 | Pharmacokinetics of oral theophylline in Thai asthmatic children. ( Geadsomnuig, S; Habananada, S; Koysooko, R; Pinthong, T; Tuchinda, M; Wattanapermpool, J, 1987) |
| "Intravenous administration of theophylline for acute asthmatic attacks treatment requires statistical adjustment of the dosage." | 3.67 | [Intravenous theophylline in the treatment of asthma attacks]. ( Blaive, B; Bonnaud, F; Clary, C; Lemoigne, F, 1987) |
| "An improved protocol was developed for the use of troleandomycin (TAO) in severe, steroid-requiring subjects with asthma." | 3.67 | An improved protocol for the use of troleandomycin (TAO) in the treatment of steroid-requiring asthma. ( Farr, RS; Friedman, BF; Wald, JA, 1986) |
| "The interaction between a new macrolide antibiotic, miocamycin, and theophylline was evaluated in a single cross-over study in 5 asthmatic children." | 3.67 | Effect of miocamycin on theophylline kinetics in children. ( Giuliani, MG; Onorato, J; Principi, N; Vigano, A, 1987) |
| "The purpose of this study was to determine the dose requirements and dose interval of a sustained-release theophylline sprinkle preparation (Somophyllin-12) necessary to maintain therapeutic serum theophylline concentrations in children with asthma." | 3.67 | Evaluation of a sustained-release theophylline product in children with asthma. ( Amaro-Galvez, R; Aranda, J; Canny, GJ; Chua, YY; Fox, Z; Levison, H; Misener, C; Woo, N, 1987) |
| "Relationships between theophylline concentrations in saliva and serum and lung functions were investigated in 27 asthmatic children receiving a sustained-release theophylline." | 3.67 | Saliva and serum theophylline concentration in management of asthma in children on sustained-release therapy. ( Baba, M; Iwasaki, E, 1987) |
| "The efficacy of maintenance theophylline therapy at serum concentrations ranging between 8 and 20 micrograms/ml was studied over a six-month period in a group of 100 outpatients (age range 18-80 years) with chronic asthma." | 3.67 | Efficacy of maintenance of therapeutic serum concentrations of theophylline in chronic asthma. ( Barrueco, M; Dominguez-Gil, A; Gomez, F; Mariño, E; Otero, MJ, 1987) |
| "For assessing the clinical impact of nonlinearity in theophylline elimination, we examined the incidence of individuals with an apparent Michaelis-Menten kinetics (percent change in plasma concentration exceeding that in dose by at least 50%) among asthmatic children (n = 122) and adults (n = 50) screened through a two-step chart review." | 3.67 | Incidence of apparent Michaelis-Menten kinetic behavior of theophylline and its parameters (Vmax and Km) among asthmatic children and adults. ( Ishizaki, T; Kubo, M, 1987) |
| "The effects of pregnancy on the disposition of theophylline were assessed in 10 patients throughout pregnancy and post-partum." | 3.67 | Longitudinal effects of pregnancy on the pharmacokinetics of theophylline. ( Cousins, L; Gardner, MJ; Jusko, WJ; Middleton, E; Schatz, M; Zeiger, R, 1987) |
| "Intrasubject variability in theophylline pharmacokinetics was assessed in six subjects with mild/moderate asthma." | 3.67 | Intraindividual variability in theophylline pharmacokinetics in subjects with mild/moderate asthma. ( Adams, E; Choi, L; Goldberg, A; Middleton, E; Slaughter, RL, 1987) |
| "The concentrations of theophylline, terbutaline and salbutamol in post-mortem blood samples from 68 patients (17-85 years old) with asthma or chronic obstructive lung disease, 54 of whom had died of asthma, were analysed." | 3.67 | Post-mortem concentrations of salbutamol, terbutaline and theophylline in asthma patients. ( Boman, G; Lindsjö, M; Lindström, B; Strandberg, K; Wiholm, BE, 1987) |
| "Theophylline absorption from 2 sustained-release theophylline (S-RT) formulations was examined over 2 consecutive days during continuous therapy in 8 clinically stable hospitalized patients with moderate to severe asthma." | 3.67 | Theophylline absorption from two sustained-release products. Implications for therapeutic drug monitoring. ( Hill, MR; Rogers, RJ; Szefler, SJ; Wiener, MB, 1987) |
| "Intraindividual changes in theophylline clearance were examined in 13 children with acute exacerbation of asthma receiving a 72-hour constant intravenous infusion of aminophylline." | 3.67 | Intraindividual changes in theophylline clearance during constant aminophylline infusion in children with acute asthma. ( Ishizaki, T; Kanagawa, S; Kubo, M; Nagai, T; Odajima, Y; Yamaguchi, M, 1986) |
| "An asthmatic patient required very high doses of theophylline (2." | 3.67 | Large theophylline requirements due to high theophylline clearance: verification by the antipyrine test. ( Blyden, GT; Greenblatt, DJ; LeDuc, BW, 1986) |
| "Eleven methods for pharmacokinetic determination of theophylline dose were compared, based on the ability of each method to predict theophylline serum concentration and clearance for adults with asthma." | 3.67 | Accuracy of 11 methods for predicting theophylline dose. ( Paloucek, FP; Rodvold, KA; Zell, M, 1986) |
| "To test the hypothesis that nighttime and early morning signs and symptoms of air flow obstruction in patients with moderately severe asthma would be better controlled by theophylline given on a once-a-day evening dosing schedule chosen to provide a peak blood level in the early morning than by the traditional twice-a-day dosing schedule designed to maintain levels more constant throughout the 24-hour period, the effects on nocturnal asthma of Uniphyl once a day and Theo-Dur twice a day were studied in 14 patients with moderately severe asthma." | 3.67 | Timing of once-a-day theophylline dose to match peak blood level with diurnal variation in severity of asthma. ( Conrad, E; Reed, CE; Welsh, PW, 1986) |
| "We examined two rapid methods of measuring theophylline clearance using pairs of serum concentration measurements, and compared them with the steady-state values in 31 patients with acute asthma." | 3.67 | Early estimate of theophylline clearance during intravenous infusion. ( Bonanno, A; Bonsignore, G; Ferrara, G; Mangiacavallo, A; Mirabella, A; Rizzo, A, 1986) |
| "To assess the utility of a dose-titration scheme for determining maintenance theophylline requirements, dose requirements and stability of serum concentrations were examined using 3537 serum determinations from 1073 patients with chronic asthma during a 5-year period." | 3.67 | Evaluation of a scheme for establishing and maintaining dosage of theophylline in ambulatory patients with chronic asthma. ( Hendeles, L; Milavetz, G; Vaughan, LM; Weinberger, MM, 1986) |
| "The incidence of preeclampsia was reduced among asthmatic patients taking theophylline (one of 85) compared to other asthmatic patients (six of 68, p less than 0." | 3.67 | Incidence of preeclampsia among asthmatic patients lower with theophylline. ( Boike, GM; Bottoms, SF; Dombrowski, MP; Wald, J, 1986) |
| "Theophylline pharmacokinetics were studied serially in five women during and after pregnancy." | 3.67 | Theophylline pharmacokinetics in pregnancy. ( Atkinson, AJ; Chow, MJ; Frederiksen, MC; Ruo, TI, 1986) |
| "Fifteen asthmatic patients receiving a sustained-release theophylline preparation were also treated with spiramycin for at least 5 days." | 3.67 | Spiramycin has no effect on serum theophylline in asthmatic patients. ( Bigot, MC; Debruyne, D; Jehan, A; Lechevalier, B; Moulin, M; Prevost, JN, 1986) |
| "Theophylline clearance was prospectively studied in eight pregnant asthmatic patients who were receiving maintenance doses of theophylline." | 3.67 | Theophylline clearance during pregnancy. ( Carter, BL; Driscoll, CE; Smith, GD, 1986) |
| "Forced expiratory volume in the first second (FEV1) and serum theophylline levels were measured comparatively in 26 patients with stable bronchial asthma after a 240 mg theophylline infusion." | 3.67 | [Serum levels and bronchodilatation after intravenous administration of theophylline in asthmatic patients]. ( Andrejak, M; Aubry, P; Lary, H; Levi-Valensi, P, 1986) |
| "Two patients are presented who required higher than usual doses of theophylline to control their asthma." | 3.67 | High theophylline doses required for asthma control. ( Jones, LM, 1986) |
| "A method for converting pediatric patients from intravenous aminophylline to sustained-release oral theophylline was evaluated in eight asthmatic children." | 3.67 | Conversion from intravenous to sustained-release oral theophylline in pediatric patients with asthma. ( Clarke, DF; Grodin, MA; Shargel, L; Werbowsky, OL, 1986) |
| "The influence of age on the disposition of theophylline was studied in 95 adult patients (nonsmokers) with bronchial asthma requiring oral theophylline therapy: 17 patients age less than or equal to 39 years, 50 patients age 40-59 years, and 28 patients greater than or equal to 60 years." | 3.67 | Individualization of theophylline dosage in adults with bronchial asthma. ( Barrueco, M; Dominguez-Gil, A; Gomez, F; Mariño, EL; Otero, MJ, 1986) |
| "Plasma and saliva theophylline concentrations were measured in 21 asthmatic subjects receiving chronic oral therapy with a new sustained-release theophylline capsule (K1B Riker) given as a once daily dose, after titration to achieve a before-dose concentration of 8 mg l-1 or greater, or to the maximum dose of 1200 mg of theophylline daily." | 3.67 | Steady-state pharmacokinetics and effects of a new once-daily, slow-release theophylline capsule preparation in asthma. ( Alwazir, YA; Campbell, IA; Routledge, PA; Williams, PE, 1986) |
| " In order to evaluate the relative contribution of vagal and non-vagal afferences to increasing neural drive to the respiratory muscles in 14 asymptomatic asthmatic patients known to be responsive (decrease in FEV1 greater than 20% of the control values) to previous bronchial provocation test (BPT) with aerosolized histamine, we evaluated FEV1, breathing pattern and neuromuscular drive, as assessed by mouth occlusion pressure (PO." | 3.67 | Effects of histamine and reproterol inhalation on mouth occlusion pressure in patients with bronchial asthma. ( Arcangeli, P; Duranti, R; Emmi, L; Gigliotti, F; Lo Conte, C; Scano, G; Spinelli, A; Stendardi, L; Turco, R, 1986) |
| "Sustained-release theophylline compounds given once (Uniphyl) or twice (Theodur) daily were compared in adult asthmatics." | 3.67 | Comparison of once-a-day and twice-a-day theophylline in asthma. ( Fairshter, RD; Lowe, JE; Novey, HS; Salness, K; Wilson, AF, 1986) |
| "To determine the usefulness of clinical information in predicting theophylline levels, 21 parameters were studied in 204 asthmatic patients." | 3.67 | Clinical predictors of theophylline blood levels in asthmatic patients. ( Marcus, RH; Parvin, CA; Stine, RJ, 1987) |
| "The authors report the results obtained with one single daily dose of 10 mg/kg of a long-acting theophylline preparation administered in the evening to asthmatic patients previously treated with the same dose twice a day." | 3.67 | [Value of a daily dose of theophylline in the treatment of nocturnal asthma]. ( Godard, P; Kleisbauer, JP; Mazoyer, F; Muir, JF; Paramelle, B, 1986) |
| "A group of 167 pediatric asthmatics were followed up over four years, and their theophylline clearance values were recorded when they were admitted for status asthmaticus." | 3.67 | The use of theophylline clearance in pediatric status asthmaticus. I. Interpatient and intrapatient theophylline clearance variability. ( Anolik, R; Kolski, GB; Levy, J, 1987) |
| "The reliability and accuracy of salivary theophylline levels as a predictor of serum theophylline levels was investigated in 28 hospitalized chronic asthmatics, free of other chronic diseases, on continuous aminophylline infusion for greater than 24 hours." | 3.67 | Reliability and predictive value of salivary theophylline levels. ( Bjornson, L; Chiaramonte, LT; Goldstein, S; Jaber, M; Schneider, AT; Sergiou, H, 1987) |
| "Asthmatic children receiving theophylline or steroid-theophylline combination therapy and normal nonasthmatics were given tests of visual retention and paired-associate learning." | 3.67 | Mnemonic effects of asthma medication in children. ( Chai, H; Kalisker, A; Stump, N; Suess, WM, 1986) |
| "In 78 children (4 to 17 years of age) with moderate or severe asthma who were additionally treated with sustained-release theophylline preparations, different ways of drug monitoring were examined." | 3.67 | [Monitoring long-term therapy with theophylline preparations in children with asthma]. ( Bauer, J; Lindemann, H; Schwandt, HJ, 1985) |
| "Cromolyn sodium has matured as a first-line drug in the management of asthma in the United States." | 3.67 | Cromolyn sodium in the treatment of asthma: coming of age in the United States. ( Bernstein, IL, 1985) |
| "Drug therapy of asthma chiefly relies on beta 2-mimetics, corticosteroids, theophyllines and disodium cromoglycate." | 3.67 | [Routine treatment methods in respiratory allergy]. ( Bonstein, H, 1985) |
| "A sustained-release theophylline preparation (Theo-Dur Sprinkle) was evaluated in young asthmatic patients aged 1 to 6 years and receiving a daily dose of 23." | 3.67 | Evaluation of serum theophylline concentrations following administration of sustained-release beads in applesauce to asthmatic preschool children. ( Correia, J; Isles, AF; Leeder, JS; Levison, H; Macleod, SM; Robertson, C, 1986) |
| "Doxycycline (D) is often administered during respiratory infections to asthmatic patients, many of them treated by theophylline (T) as well." | 3.67 | Serum theophylline concentrations are not affected by coadministration of doxycycline. ( Farfel, Z; Schey, G; Seggev, JS; Shefi, M, 1986) |
| "We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer." | 3.67 | Perforated gastric ulcer in an asthmatic treated with theophylline and steroids. Case report and literature review. ( Chiaramonte, LT; Guss, C; Schneider, AT, 1986) |
| "The bioavailability and absorption pattern of theophylline from a single dose of a slow release theophylline sprinkle product (Somophyllin) were investigated in 10 asthmatic children both in fasting conditions and after a standardized breakfast." | 3.67 | Food and fasting absorption of a single dose of a sustained release theophylline sprinkle formulation in children. ( Pedersen, S; Steffensen, G, 1986) |
| "Thirty-nine chronic asthmatic children were enrolled in a 6-month outpatient theophylline compliance study." | 3.67 | Theophylline compliance in asthmatic children. ( Cuskey, W; Weinstein, AG, 1985) |
| "During routine monitoring of hospitalized children with asthma receiving a sustained-release theophylline formulation, we frequently observe unpredictable fluctuations in serum theophylline concentration (STC)." | 3.67 | Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children. ( Kalisker, A; Rogers, RJ; Szefler, SJ; Wiener, MB, 1985) |
| "The case is presented of a 39-year-old male in status asthmaticus who failed to respond to conventional therapy, including positive pressure ventilation, and who required halothane anesthesia." | 3.67 | The use of halothane in the treatment of status asthmaticus. ( Bayliff, CD; Faclier, G; Koch, JP, 1985) |
| "After literature reports linking fibrocystic breast disease (FBD) to methylxanthine ingestion, a pilot study was undertaken to investigate the possible contribution of theophylline to this effect." | 3.67 | Theophylline and fibrocystic breast disease. ( Bullough, B; Hindi-Alexander, MC; London, WM; Middleton, E; Montes, N; Rosner, DH; Zielezny, MA, 1985) |
| "The disposition of theophylline was examined in seven children with asthma on two occasions before and on one occasion after chronic phenobarbital dosing (2 mg/kg/day)." | 3.67 | The effect of phenobarbital on theophylline disposition in children with asthma. ( Danish, M; Greene, J; Mansmann, HC; Ragni, MC; Rocci, ML; Saccar, CL; Yaffe, SJ, 1985) |
| "Ten ambulatory subjects with asthma experienced a seizure while they were receiving oral theophylline preparations and were evaluated prospectively according to a set protocol." | 3.67 | The relationship of cerebrospinal fluid and plasma theophylline concentrations in children and adolescents taking theophylline. ( Auritt, WA; Mansmann, HC; McGeady, SJ, 1985) |
| "The clinical pharmacodynamics of theophylline, which concerns the correlation between the serum theophylline concentration ([TH]) attained during therapy for asthma and improved pulmonary function or unwanted side effects, serves to link the pharmacokinetics of theophylline with the time course of clinical outcome." | 3.67 | Clinical pharmacodynamics of theophylline. ( Baker, J; Ezra, D; Lenert, LL; Nichols, AI; Peck, CC, 1985) |
| " The topical anti-inflammatory treatment provided by inhaled steroids thus compares favorably with prednisolone and with other asthma therapy with respect to morbidity and mortality, suggesting that inhaled steroids combined with an inhaled beta-agonist is a safe and comprehensive treatment for chronic asthma." | 3.67 | Inhaled corticosteroid therapy: a substitute for theophylline as well as prednisolone? ( Clark, TJ, 1985) |
| "The lung function profiles of a group of six healthy volunteers and six patients with moderately severe asthmatic bronchitis were compared after one theophylline infusion and after oral administration of Theograd (350 mg), Theolair Retard (350 mg), and Theolin Retard (300 mg) all given twice daily for 1 week." | 3.67 | Pharmacokinetics and pharmacodynamics of three sustained-release theophylline preparations (Theograd, 350 mg Theolair Retard, and 300 mg Theolin Retard) in steady state in six normals and six patients with chronic asthmatic bronchitis--Part II: Lung funct ( Drost, RH; Kreukniet, J; Maes, RA; van der Vet, AP, 1985) |
| "Fifty two preschool children with asthma were given a recommended regimen of slow release theophylline." | 3.67 | Treatment of asthma in preschool children with slow release theophylline. ( Loftus, BG; Price, JF, 1985) |
| "A sustained-release theophylline (SRT) tablet was evaluated in 15 children with moderately severe asthma between the ages of 3 and 5 years (4." | 3.67 | Evaluation of a sustained-release theophylline tablet in young asthmatics. ( Baldwin, JN; Kobayashi, RH; Swigart, SA, 1985) |
| " At about the same time that the Progestasert system was being developed, a membrane-based ocular system also was developed for the delivery of pilocarpine to treat glaucoma." | 3.67 | Membrane systems: practical applications. ( Smith, KL, 1985) |
| "In accordance with a case report of a 7-year-old boy with bronchial asthma, who was twice treated with aminophylline and each time reacted upon this with an aggressive behaviour, which was completely abolished after stopping the medication and which did not appear after application of theophylline, we became suspicious, that this side effect could be due only to the ethylenediamine." | 3.67 | [Aggressive behavior as a side effect of ethylenediamine (but not of theophylline)]. ( Niggemann, B, 1985) |
| "Several theophylline pharmacologic strategies were tested for the forgetful medication-dependent asthmatic who frequently initiates treatment from below the therapeutic range of 10 to 20 micrograms/mL." | 3.67 | Sustained release theophylline for the forgetful asthmatic. ( Weinstein, AG, 1985) |
| "To evaluate the dose-effect relationship of a controlled-release theophylline in preschool children, 20 patients with asthma (mean age 4." | 3.67 | Clinical and bronchodilating efficacy of controlled-release theophylline as a function of its serum concentrations in preschool children. ( Duiverman, EJ; Graatsma, BH; Kerrebijn, KF; Neijens, HJ, 1985) |
| "The trough steady-state concentration of theophylline in plasma and stimulated saliva of 12 asthmatic children receiving an oral slow-release theophylline preparation was determined after 1 week of treatment." | 3.67 | Relationship between plasma and stimulated-saliva concentrations of theophylline in asthmatic children. ( Hoffer, E; Krivoy, N; Rubin, A; Teitelman, U; Zinman, P, 1985) |
| "We studied 16 adults with chronic bronchial asthma by measuring the plasma theophylline concentrations and evaluating clinically the control of asthma following oral administration of choline theophyllinate (CT) and a sustained-release theophylline preparation (SRT)." | 3.67 | A comparative study of the use of choline theophyllinate and a sustained-release theophylline in adults with chronic asthma. ( Chan, KW; Feng, PH; Lee, HS; Tan, TH; Ti, TY, 1985) |
| "Two sustained-release theophylline preparations, one a 12-hour and the other a 24-hour product, were compared in 20 subjects with stable asthma." | 3.67 | Study of two controlled-release theophylline preparations. ( Conrad, E; Fink, JN; Levy, MB, 1985) |
| "The effects of histamine, antihistamines, isoproterenol and theophylline on the expressions of Fc and complement (C') receptors on the polymorphonuclear leukocytes (PMN's) were studied in 40 asthmatic children." | 3.66 | The effects of histamine, antihistamines, isoproterenol and theophylline on the Fc and complement receptor functions of polymorphonuclear leukocytes in asthmatic children. ( Hsieh, KH, 1981) |
| "Theophylline is a potent bronchodilator that can be effective as maintenance medication for preventing chronic symptoms of asthma." | 3.66 | Improved efficacy and safety of theophylline in the control of airways hyperreactivity. ( Hendeles, L; Weinberger, M, 1982) |
| "In 9 "stable" adult asthmatics, the relationship between serum theophylline level and pulmonary function, as well as the interaction of aminophylline and inhaled beta2-agonist on pulmonary function, were studied." | 3.66 | Relationship between serum theophylline levels and pulmonary function before and after inhaled beta-agonist in "stable" asthmatics. ( Cherniack, RM; Klein, JJ; Lefkowitz, MS; Spector, SL, 1983) |
| " Recommended initial outpatient treatment of sporadic asthma consists of administration of an inhaled beta 2 agent, followed as necessary by a systemic beta 2 agent, a long-acting theophylline preparation, cromolyn, and inhaled ipratropium." | 3.66 | Asthma therapy. Advantages and limitations of various approaches. ( Schwartz, SH, 1983) |
| "Two groups of asthmatic children were found with regard to the influence of theophylline on the anti-IgE-induced histamine release from whole blood." | 3.66 | In vitro influence of theophylline on anti-IgE-induced release from leucocytes and whole blood in asthmatic children. ( Burtin, C; Fermanian, J; Lebel, B; Paupe, H; Scheinmann, P, 1981) |
| "Studies using the guinea pig ileum bioassay technique have previously shown that patients with either asthma or chronic bronchitis have increased amounts of histamine in their sputum." | 3.66 | Histamine content of sputum from patients with asthma and chronic bronchitis. ( Bryant, DH; Pui, A, 1982) |
| "Authors have studied pharmacokinetic parameters of theophylline in a sample of 21 children with bronchial asthma, through evolution of plasmatic concentrations, evaluated by RIA, in order to appreciate therapeutic response to it depending on the time-variation of such concentrations." | 3.66 | [Pharmacokinetics of theophylline in infantile bronchial asthma. Clinical findings]. ( Girón, F; Loscertales, M; Martínez Sampere, JJ; Olea, N; Pedraza, V; Puentes, C; Ruiz Estremera, A, 1982) |
| "Verapamil was found to be an effective inhibitor of isometric tension in in vitro, experimental anaphylaxis in guinea pig trachealis smooth muscle." | 3.66 | Effect of calcium antagonists in experimental asthma. ( Barbero, L; Markowicz, J; Weiss, EB, 1982) |
| "The absolute T-cell numbers and function, and the T-suppressor-cell subset were tested in eleven children with extrinsic asthma prior to and 1 month after theophylline treatment." | 3.66 | Induction of suppressor T cells in asthmatic children by theophylline treatment. ( Shohat, B; Varsano, I; Volovitz, B, 1983) |
| "The effect of therapeutic doses of theophylline on the pituitary-thyroid axis was studied in four normal adults and in 15 asthmatic children on theophylline treatment." | 3.66 | Effect of sustained-release theophylline administration on pituitary-thyroid axis. ( Hiratani, M; Ito, S; Kasei, M; Muto, K; Oshida, Y; Sato, T; Ueda, S, 1982) |
| "Beta-adrenergic refractoriness was assessed in human lymphocytes following in vivo administration of the beta-adrenergic agonist, metaproterenol, the phosphodiesterase inhibitor, theophylline, or both concomitantly, to normal and asthmatic subjects." | 3.66 | Lymphocyte beta-adrenergic refractoriness induced by theophylline or metaproterenol in healthy and asthmatic subjects. ( Abrass, IB; Littner, MR; Scarpace, PJ; Tashkin, DP, 1982) |
| " was used to predict theophylline kinetics in eleven critically ill patients with either acute severe asthma or bronchoconstriction." | 3.66 | Pharmacokinetic optimisation of aminophylline infusions in critically ill patients. ( Ilett, KF; Nation, RL; Oh, TE; Silbert, B, 1983) |
| "A pediatric patient who was taking carefully monitored doses of theophylline for chronic asthma, was placed on erythromycin base for bronchitis." | 3.66 | Interaction of theophylline with erythromycin base in a patient with seizure activity. ( Burns, RM; Haulman, NJ; Parish, RA, 1983) |
| "Twenty children aged between 5 and 16 suffering from severe asthma were treated with long acting oral theophylline." | 3.66 | [Sustained-action oral theophylline in the asthmatic child. Clinical, pharmacokinetic and respiratory function studies]. ( Baculard, A; Boule, M; Gaultier, C; Morgant, G; Tournier, G, 1983) |
| "Ninety-three patients presenting with acute asthma to the emergency department were studied to determine theophylline levels and their relationship to airway obstruction, history of prior medication use, and side effects of treatment." | 3.66 | Theophylline concentrations in the emergency treatment of acute bronchial asthma. ( Anderson, JA; Emerman, CL; Nowak, RM; Sarkar, D; Tomlanovich, MC; Yanari, S, 1983) |
| "The absolute oral bioavailability of a sustained release theophylline tablet (Nuelin-SR250), given 12 hourly was determined in 14 asthmatic children aged 5 to 13 years." | 3.66 | Bioavailability and diurnal variation in absorption of sustained release theophylline in asthmatic children. ( Birkett, DJ; Coulthard, KP; Grgurinovich, N; Grygiel, JJ; Lines, DR, 1983) |
| "Analyses of 90 admissions to the Cincinnati Children's Hospital Center, Cincinnati, Ohio, were used to assess the effects of the routine availability of serum theophylline determinations (STD) in treating acute in-hospital asthma over three one-year review periods coinciding with the relative availability of STD." | 3.66 | Use of serum theophylline determinations during acute asthma therapy in children. ( Fischer, TJ; Hunter, RH; Kearns, GL, 1982) |
| "In a 12-week study 20 children, ages two to seven years, with moderate to severe asthma received 20 mg cromolyn sodium via a power-driven nebulizer four times daily." | 3.66 | Safety, efficacy and bronchodilator-sparing effects of nebulized cromolyn sodium solution in the treatment of asthma in children. ( Prenner, BM, 1982) |
| "Eleven children suffering from an acute asthma attack were treated with 6 mg theophylline/kg given as a single dose of a new theophylline liquid (Nuelin Liquid, Riker) (day 1)." | 3.66 | Pharmacokinetics of a new theophylline liquid in asthmatic children. ( Pedersen, S, 1983) |
| "This study was performed to assess the need of obtaining serum theophylline (T) levels between 10--20 micrograms/ml to achieve maximum reversibility of airway obstruction in chronic childhood asthma." | 3.66 | Theophylline administration in children with asthma: optimal pulmonary function and possible tolerance to chronic administration. ( Katz, RM; Mickey, R; Rachelefsky, GS; Siegel, SC, 1983) |
| "To facilitate administration of sustained-release theophylline in pediatric patients fourteen children with asthma were studied using intact capsules versus the granular contents in apple sauce." | 3.66 | Bioavailability of sustained-release theophylline granules in apple sauce in pediatric asthmatic patients. ( Carroll, S; Lotner, GZ; Spangler, DL; Tinkelman, DG; Vanderpool, GE, 1983) |
| "Thirty-three chronic asthmatic children and adolescents on predetermined doses of theophylline preparations who arrived at the Emergency Room with an acute episode of wheezing were evaluated to determine compliance, and if therapeutic plasma theophylline levels (PTLs) facilitate the effectiveness of epinephrine." | 3.66 | Assessment of acute asthma in the emergency room: evaluation of compliance and combined drug therapy. ( Chryssanthopoulos, C; Laufer, P; Torphy, DE, 1983) |
| "In order to determine the types of respiratory responses observed during aspirin-induced reactions, 50 consecutive asthmatic patients with a history of aspirin sensitivity underwent prospective oral aspirin challenges between 1979 and 1981." | 3.66 | Aspirin-sensitive rhinosinusitis/asthma: spectrum of adverse reactions to aspirin. ( Mathison, DA; Pleskow, WW; Schatz, M; Simon, RA; Stevenson, DD; Zeiger, RS, 1983) |
| "Continuous sustained-release theophylline therapy was used in 61 children with severe asthma, aged 5 to 16 years." | 3.66 | [Continuous treatment of asthma in children with theophylline retard]. ( Benoist, MR; de Blic, J; Paupe, J; Ruff, F; Scheinmann, P, 1983) |
| "Plasma concentration and pharmacokinetic data of a sustained-release theophylline (Theolair retard) was compared with that of a short-acting theophylline (Theolair) in six normals and six patients with asthmatic bronchitis." | 3.66 | Pharmacokinetics and pharmacodynamics of a short- and long-acting theophylline medication (theolair and Theolair retard) in normals and asthmatics. Part I: pharmacokinetics. ( Kreukniet, J; Maes, RA; Meering, PG; Utama, I, 1983) |
| "Serial serum theophylline levels were measured in 20 inpatient asthmatics given tablets of either microcrystalline or sustained-release theophylline." | 3.66 | Serum theophylline levels in adult asthmatics: comparison of oral sustained-release and microcrystalline preparations. ( Jones, DT; Sears, MR, 1980) |
| "Dihydroxypropyl theophylline (dyphylline) was administered by aerosol in a single dose of 250 mg aerosolized over five minutes to two asthmatic volunteers and in a single dose of 375 mg aerosolized over ten minutes to two other asthmatic volunteers." | 3.66 | Dyphylline aerosol can induce bronchospasm in human asthmatics. ( Auer, S; Bardana, E; Brottem, J; Downes, H; Hirshman, C; Lawyer, C; Lynn, R, 1982) |
| "The newborn's potential for xanthine toxic reactions from placental transfer of theophylline or caffeine conversion from theophylline was studied in 12 newborns of asthmatic mothers." | 3.66 | Placental theophylline transfer in pregnant asthmatics. ( Labovitz, E; Spector, S, 1982) |
| " The added observation that theophylline and salbutamol were effective suggests that the condition is a manifestation of asthma." | 3.66 | Persistent cough a forme-fruste of asthma. ( Benzaray, S; Katznelson, D; Yahav, Y, 1982) |
| "Aminophylline and isoproterenol were simultaneously administered by continuous intravenous infusion to six patients with status asthmaticus and acute respiratory failure." | 3.66 | Effect of intravenous isoproterenol on theophylline kinetics. ( Hemstreet, MP; Miles, MV; Rutland, RO, 1982) |
| "During the 1980 influenza B outbreak in King County, Washington, 11 children whose asthma had previously been controlled with a stable theophylline dose, developed theophylline toxicity on this same dose." | 3.66 | Altered theophylline clearance during an influenza B outbreak. ( Bierman, CW; Furukawa, CT; Koup, JR; Kraemer, MJ; Pierson, WE; Shapiro, GG, 1982) |
| "The kinetics and the effects on the ventilatory function peak expiratory flow rate (PEFR) of a single 600-mg oral dose of theophylline were investigated in 46 adult patients with bronchial asthma (BA) and in 16 adult patients with chronic airflow obstruction (CAO)." | 3.66 | Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: influence of erythromycin. ( Bah, H; Duroux, P; Giudicelli, JF; Mathieu, M; Richer, C; Thuillez, C, 1982) |
| "Theo-Dur, a sustained-release theophylline formulation, was administered every 12 hours for three months to ten asthmatic children aged 3 to 7 years, with no evidence of adverse reaction or tolerance." | 3.66 | Sustained-release theophylline for treatment of asthma in preschool children. ( Luciuk, GH; Simons, FE; Simons, KJ, 1982) |
| "Allergy and/or contraindications for theophylline and adrenergic drugs can be a life-threatening problem for patients with respiratory failure resulting from status asthmaticus." | 3.66 | Pulmonary lavage in a patient in status asthmaticus receiving mechanical ventilation: a case report. ( Maxson, TR; Shridharani, M, 1982) |
| "Long-term treatment of childhood asthma with theophylline or theophylline ethylenediamine (Aminophyllin) preparations requires dosage according to the various age groups." | 3.66 | [Serum theophylline levels in aminophyllin treatment in children]. ( Alterthum, K; Bauer, P; Müller, G; Windorfer, A, 1982) |
| "A retrospective analysis of the records of 56 children admitted in status asthmaticus was done to assess the impact of serum theophylline levels on subsequent therapeutic decisions." | 3.66 | Theophylline blood levels as a guide to intravenous therapy in children. ( Davis, WJ; Feldman, BR; Feldman, CH; Fox, J; Hicks, P, 1982) |
| "Drug therapy of asthma in the elderly with sympathomimetics, theophylline, steroids, and mucokinetic agents is described, with discussion of dosage evaluation, toxicity, possible drug interactions, and suggested management of common problems." | 3.66 | Management of respiratory problems in the aged. ( Ziment, I, 1982) |
| "The bronchodilating properties and side effects of theophylline and a beta 2-adrenoceptor stimulating drug (terbutaline) alone and in combination were studied in 10 adult asthmatic patients." | 3.66 | Separate and combined use of terbutaline and theophylline in asthmatics. Effects related to plasma levels. ( Billing, B; Dahlqvist, R; Garle, M; Hörnblad, Y; Ripe, E, 1982) |
| "Theophylline reduces asthmatic bronchial obstruction; this desired therapeutic action but also the occurrence of unpleasant and dangerous side effects depends directly on its tissue and serum concentration." | 3.66 | [Theophylline in the treatment of childhood asthma]. ( Zach, M, 1982) |
| "Intravenous maintenance aminophylline infusion rate can be calculated from the previously received equivalent oral dosage in children with chronic asthma with considerable accuracy." | 3.66 | Intravenous maintenance aminophylline dosage in patients with asthma on regular oral theophylline. ( Bell, TD; Chai, H; Chang, KC; Miles-Lawrence, R; Pinney, CT, 1982) |
| "The authors followed up the plasma theophylline level in 51 patients with bronchial asthma treated with novphyllin." | 3.66 | [Plasma theophylline level in patients with bronchial asthma treated with novphyllin]. ( Dimitrov, V; Kosturkov, G; Mileva, Zh; Slavov, S; Vasileva, S, 1982) |
| "Fifteen adult chronic asthmatic patients were studied on 6 consecutive days of the second week of treatment with a new sustained release theophylline formulation, and 8 were again studied after three months on the same dosing regimen (375 mg b." | 3.66 | Components of variability in serum theophylline concentrations during maintenance therapy with a sustained release formulation. ( Almog, S; Halkin, H; Mazar, A; Schnaps, Y, 1982) |
| "Serum levels of theophylline were determined in 54 asthmatics children aged 3,92 +/- 2,45 years, who were taken oral theophylline at doses of 4,99 +/- 0,45 mg." | 3.66 | [Serum theophylline levels after oral administration in a group of asthmatic children]. ( Borges Domingo, T; de la Morena, E; Escorihuela, R; Lillo Lillo, M; Llerena, P; López-Linares, M; Royo, F, 1982) |
| "18 elderly patients (17 male and 1 female) with chronic obstructive pulmonary disease, and 2 elderly patients (1 male, 1 female) with an acute asthmatic attack were treated with theophylline." | 3.66 | Maintenance oral theophylline therapy: suggested schedule in elderly patients. ( Alroy, G; Krivoy, N, 1980) |
| "This study compared the bronchodilator effect in experimental canine asthma of dyphylline administered by aerosol and intravenous routes in doses producing equivalent concentrations of the drug in the plasma." | 3.66 | Dyphylline aerosol attenuates antigen-induced bronchoconstriction in experimental canine asthma. ( Downes, H; Farbood, A; Gerber, N; Hirshman, CA; Lawyer, C; Rodgers, R, 1981) |
| "A patient developed severe asthma following insulation of her house with urea-formaldehyde foam." | 3.66 | Asthma induced by dust from urea-formaldehyde foam insulating material. ( Filley, WV; Frigas, E; Reed, CE, 1981) |
| "Authors have adjusted oral theophylline requirements in 55 asthmatic children, whose ages ranged from 19 months to 14 years, following a preconceived plan." | 3.66 | [Individualization of the dosage of oral theophylline with regular increase method and serum level control in 55 asthmatic children (author's transl)]. ( Cabanas, R; Castro-Gago, M; Cortizo, E; Fuster, M; Peña, J; Tojo, R; Vázquez, MC, 1981) |
| "The authors studied the clinical activity of a synthetic theophylline derivative, (dl)-dihydro-1,8-dimethyl-1-3-(-2-methyl-butyl)-1 H-purine-2,6 dione, both after short-term treatment and in prevention of Exercise-Induced Asthma (EIA)." | 3.66 | Effect of (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione on exercise-induced bronchospasm. ( Casali, L; Grassi, C; Rampulla, C; Rossi, A, 1981) |
| "The pharmacokinetics of theophylline following a single intravenous dose of aminophylline were determined in 8 asthmatic patients in each of the acute, the recovery and the remission phase." | 3.66 | A comparison of the pharmacokinetics of theophylline in asthmatic children in the acute episode and in remission. ( Arnold, JD; Hill, GN; Sansom, LN, 1981) |
| " A comparative study with various drug used in the treatment of asthma (isoprenaline, metaproterenol, salbutamol, clenbuterol, papaverine and atropine) has been conducted." | 3.66 | Reproterol and the muscle of the trachea and bronchi: in vitro and in vivo comparative studies with various drugs used in the treatment of asthma. ( Di Mezza, F; Giordano, L; Marmo, E; Montanaro, A; Scognamiglio, M, 1981) |
| "A new, low dose sustained-release tablet of theophylline has been developed in order to facilitate a correct dose regimen in asthmatic children treated with theophylline." | 3.66 | Evaluation of a new sustained-release theophylline tablet for children. ( Aas, K; Alme, A; Bjerve, KS; Rugstad, HE; Selvig, K, 1981) |
| " clearance estimation methods were evaluated n 19 chronic obstructive pulmonary disease (COPD)/asthmatic patients who were receiving aminophylline by continuous infusion." | 3.66 | Evaluation of two methods for estimating theophylline clearance prior to achieving steady state. ( Anderson, G; Edwards, WD; Hook, E; Koup, J; Resman, B; Slaughter, R, 1981) |
| "During both the 1977 and 1978 eight-week summer sessions at Bronco Junction the effect of oral inhalation of beclomethasone dipropionate and optimum dose theophylline therapy in 56 chronically severe, corticosteroid dependent asthmatic children was evaluated." | 3.66 | Use of inhaled beclomethasone dipropionate and optimized theophylline doses in asthmatic children at Camp Bronco Junction, 1977-1978. ( Morton, JL; Scherr, LB; Scherr, MS, 1980) |
| "A sustained release theophylline preparation, administered on a q8h or q12h schedule, was evaluated in 12 severly asthmatic children." | 3.66 | Comparison of two dosage schedules of sustained release theophylline in pediatric patients. ( Kirsten, EB; Loren, ML, 1980) |
| " It has been known to have side effects such as dyskinesia, but this case details the emergence of dystonia and dyskinesia when the simultaneous use of methylphenidate and a phenothiazine was followed by withdrawal of the phenothiazine." | 3.66 | Methylphenidate, neuroleptics and dyskinesia-dystonia. ( Chapel, J; Husain, A; Malek-Ahmadi, P, 1980) |
| "The pharmacokinetics and urinary excretion of intravenously administered 7-(2,3-dihydroxypropyl) theophylline (dyphylline), were studied in a 37-yr-old asthmatic woman with ethylene diamine sensitivity who manifested intolerance to intravenous aminophylline on three separate occasions." | 3.66 | Utilization of intravenous dihydroxypropyl theophylline (dyphylline) in an aminophylline-sensitive patient, and its pharmacokinetic comparison with theophylline. ( Bardana, EJ; Gerber, N; Lawyer, CH; Rodgers, R, 1980) |
| "In the management of severe chronic asthma, extensive avoidance of known precipitating factors and optimum betastimulation supported by theophylline have pride of place." | 3.66 | [Problems of indication and execution of long-term steroid therapy in advanced disabling bronchial asthma]. ( Imhof, K; Scherrer, M, 1980) |
| "Theophylline preparations have long been the mainstay in the management of asthma." | 3.66 | Intravenous theophylline therapy in asthma: a clinical update. ( Rothstein, RJ, 1980) |
| "The purpose of this study was to determine whether a new sustained-release theophylline preparation TheoDur could maintain therapeutic serum theophylline levels in asthmatic children on a 12-hour dosage regimen." | 3.66 | Efficacy of a 12-hour sustained-release preparation in maintaining therapeutic serum theophylline levels in asthmatic children. ( Kelly, HW; Murphy, S, 1980) |
| "The frequency and type of dysrhythmias observed in asthmatic patients treated with epinephrine alone, and those given epinephrine and intravenous aminophylline, were compared." | 3.66 | Cardiac dysrhythmias during the treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol. ( Gibson, G; Josephson, GW; Kennedy, HL; MacKenzie, EJ, 1980) |
| " The present program for a hand-held calculator (TI-59) was written to minimize these problems, and was designed for the use of intravenous theophylline in the management of acute asthma, where there is a need for individualisation of dosage." | 3.66 | A hand-held calculator program for individualized dosage adjustment of intravenous theophylline in acute asthma. ( Madsen, BW; Paterson, JW; Tarala, RA, 1980) |
| "The effects of theophylline on lower esophageal sphincter pressure (LESP) were studied on four normal volunteers and six asthmatics with symptoms of gastroesophageal reflux (GER)." | 3.66 | The effect of theophylline on the lower esophageal sphincter pressure. ( Jacobson, KW; Mansfield, LE; McDonnell, JT; Nelson, HS; Stein, MR; Towner, TG; Weber, RW, 1980) |
| "The serum-saliva theophylline level ratio was measured in 19 chronically asthmatic children after their conditions were stabilized on a sustained-release theophylline preparation." | 3.66 | Monitoring children on sustained-release therapy by salivary theophylline levels. ( Hadley, WM; Kelly, HW; Murphy, SA; Skipper, BG, 1981) |
| "The plasma half-life of theophylline was determined during and 1 month after serologically confirmed upper-respiratory-tract viral illness in six children with chronic asthma." | 3.66 | Altered theophylline pharmacokinetics during acute respiratory viral illness. ( Bell, TD; Chai, H; Chang, KC; Lauer, BA, 1978) |
| "Serum theophylline concentrations were measured in 17 children and adolescents with acute asthma who received an aminophylline loading dose of 7 mg/kg and a constant infusion of 15 mg/kg/24 hours." | 3.66 | Pharmacokinetics of theophylline in acute asthma. ( Bierman, CW; Pierson, WE; Shapiro, GG; Simons, FE; Simons, KJ, 1978) |
| "Possible interaction of erythromycin with theophylline is a problem in the dental treatment of asthmatic patients." | 3.66 | The interaction of erythromycin and theophylline in the asthmatic dental patient. ( Hendeles, L; Walker, J, 1979) |
| "Theophylline has become useful not just as an acute bronchodilator, but also as a major prophylactic agent for the suppression of symptoms of chronic asthma." | 3.66 | Theophylline for treatment of asthma. ( Weinberger, M, 1978) |
| "Theophylline protein binding was 58-82% in serum from six normal adults and 42 asthmatic patients, 1-25 years old, who were given 5 mg of theophylline/kg." | 3.66 | Theophylline protein binding in humans. ( Briggs, CJ; Lo, L; Simons, FE; Simons, KJ, 1979) |
| "Theophylline is one of the best drugs for the therapy of bronchial asthma." | 3.66 | [Theophylline therapy--foundations and possibilities (author's transl)]. ( Iwainsky, H; Sehrt, I, 1979) |
| "Serum concentrations of theophylline following intravenous and oral administration of aminophylline were studied in asthmatic children, 2--17 years of age." | 3.66 | Serum concentrations of theophylline in children following the administration of doses generally recommended: new dosage regimen required. ( Aas, K; Bjerve, KS; Holmen, TL; Rugstad, HE; Selvig, K, 1979) |
| "The quantitative effects of theophylline anhydrous upon exercise-induced asthma (EIA) were evaluated in asthmatic children." | 3.66 | Quantitative effect of theophylline anhydrous on exercise-induced asthma after maximal physical effort. ( Bruns, WT; Chryssanthopoulos, C; Gallen, WJ; Hause, LL; Maksud, MG, 1979) |
| "Sub-therapeutic theophylline levels due to patient (parent) non-compliance is a significant cause of outpatient treatment failure in childhood asthma." | 3.66 | Non-compliance in asthmatic children: a study of theophylline levels in a pediatric emergency room population. ( Kadlec, GJ; Karibo, JM; Pollard, SJ; Sublett, JL, 1979) |
| "Twenty children, five to 16 years old, diagnosed as having asthma, were studied to compare the serum concentrations of theophylline obtained by standard venipuncture with capillary concentrations obtained by finger lancet." | 3.66 | Comparison of theophylline concentrations in venous blood and capillary blood in asthmatic children. ( Rosen, JP; Umstead, GS, 1979) |
| "Serum theophylline levels produced in asthmatic children by sustained-release theophylline tablets (TheoDur) were studied." | 3.66 | Serum theophylline levels in asthmatic children receiving sustained-release theophylline tablets. ( Kelly, HW; Murphy, S, 1979) |
| "A study was carried out in 25 patients with asthma caused by exposure to occupational antigens to investigate the effectiveness of reproterol in protecting and terminating the bronchoconstrictor response to inhaled antigens." | 3.66 | Inhibition of artifically-induced asthma by reproterol ('Bronchospasmin'). ( Bianco, S; Kamburoff, PL; Prime, FJ, 1979) |
| "Twenty-one adult chronic asthmatic patients were studied while taking a 12-hour sustained-action theophylline tablet." | 3.66 | Use of a twelve-hour theophylline preparation in chronic adult asthmatics. ( Carroll, MS; Spangler, DL; Tinkelman, D; Vanderpool, G, 1979) |
| "Theophylline dosage requirements to maintain serum concentrations of 10 to 20 microgram/ml among asthmatic patients were examined in 156 children, ages 2 1/2 months to 16 years, and 33 otherwise health adults." | 3.66 | Oral theophylline dosage for the management of chronic asthma. ( Hendeles, L; Weinberger, M; Wyatt, R, 1978) |
| "Serum theophylline concentration was measured in children both during treatment of status asthmaticus with intravenous aminophylline, and as outpatients while they were taking oral theophylline compounds for long-term management of asthma." | 3.66 | Clinical applications of serum theophylline measurement by high pressure liquid chromatography. ( Baillie, E; Edmunds, AT; McKenzie, SA; Meek, JH, 1978) |
| "Efficacy and dose-response activity of oral theophylline were evaluated in 21 asthmatic children, using inhibition of exercise-induced bronchospasm (EIB) as a therapeutic marker." | 3.66 | Exercise, induced bronchospasm in asthmatic children as a dose-response model for theophylline. ( Bierman, CW; Cho, YW; Pierson, WE; Shapiro, GG, 1978) |
| "Theophylline, when used appropriately, seems to be the most effective noncorticosteroid prophylactic medication for chronic asthma." | 3.66 | Guide to oral theophylline therapy for the treatment of chronic asthma. ( Hendeles, L; Weinberger, M; Wyatt, R, 1978) |
| "Theophylline disposition (clearance, volume of distribution, and half-life) was measured in 31 normal volunteers and 26 acutely ill patients with airway obstruction within 24 hours of hospital admission and again when intravenous aminophylline was discontinued 2 to 10 days later." | 3.66 | Theophylline disposition in acutely ill hospitalized patients. The effect of smoking, heart failure, severe airway obstruction, and pneumonia. ( Costello, J; Hopewell, P; Powell, JR; Riegelman, S; Sheiner, LB; Vozeh, S, 1978) |
| "The efficacy of continuous, around-the-clock sustained-release (S-R) theophylline therapy, adjusted to approximate serum or plasma steady state theophylline concentrations (Tc) of 15 microgram/ml three hours following the last dose, was assessed in 18 children suffering from moderately severe chronic asthma." | 3.66 | Sustained-release theophylline therapy for chronic childhood asthma. ( Bell, T; Bigley, J, 1978) |
| "The present study compares the pharmacokinetic characteristics of equivalent theophylline doses of a delayed release formulation of oxtriphylline and a sustained release formulation given as single or six hourly repetitive dosings in six adult asthmatics." | 3.66 | Pharmacokinetics of delayed (DR) versus sustained release (SR) theophylline formulations following single (SD) and repetitive dosing (RD). ( Bell, T; Katsampes, C; Leung, P, 1978) |
| "Serum theophylline concentrations measured in 25 asthmatic children for whom continual therapy had been prescribed were found to exceed 8 mcg/ml more often in those receiving sustained-release theophylline preparations than those receiving short-acting theophylline preparations." | 3.66 | Serum theophylline concentrations in asthmatic children. ( Sheen, A; Sly, RM, 1978) |
| "Serum theophylline levels were measured throughout the day in 65 asthmatic children receiving one of two slow-release theophylline compounds." | 3.66 | Serum theophylline levels in asthmatic children after oral administration of two slow-release theophylline preparations. ( Baillie, E; McKenzie, S, 1978) |
| "Twenty asthmatics and 14 non-atopic controls were given long-acting theophylline tablets, 400 mg twice daily, and were then challenged, after a control period, with 0." | 3.65 | Effect of salbutamol inhalations of plasma and urinary cyclic adenosine monophosphate levels in asthmatics and non-atopic controls. ( Härkönen, M; Muittari, A; Raij K-Alanko, K, 1976) |
| "Monolayers of adherent mononuclear leukocytes prepared from normal subjects and asthmatic children whose bronchodilater therapy did not include sympathomimetic drugs, respond to relatively low concentrations of isoproterenol (ISO) and prostaglandin E1 with increased intracellular cyclic adenosine monophosphate (cAMP) levels." | 3.65 | Drug-induced changes of adenylate cyclase activity in cells from asthmatic and nonasthmatic subjects. ( Kalisker, A; Middleton, E; Nelson, HE, 1977) |
| "Ten patients with exercise-induced asthma were premedicated with oral salbutamol and oral theophylline on separate occasions before performing a standardised exercise test." | 3.65 | A comparison of oral theophylline and oral salbutamol in exercise-induced asthma. ( Anderson, SD; Lindsay, DA; Seale, JP, 1977) |
| "To test the efficacy of using a weight-derived formula to determine aminophylline dosages, 50 patients hospitalized for treatment of severe asthma were given intravenous aminophylline infusions at a rate of 0." | 3.65 | Theophylline concentrations in asthmatic patients after administration of aminophylline. ( Kordash, TR; McCall, JT; Van Dellen, RG, 1977) |
| "This study examined the effectiveness of theophylline therapy in modifying exercise-induced bronchospasm (EIB) in children with perennial asthma and evaluated whether tolerance to theophylline developed with prolonged use." | 3.65 | Acute and chronic theophylline therapy in exercise-induced bronchospasm. ( Bierman, CW; Dorsett, CS; Pierson, WE; Shapiro, GG, 1977) |
| "Seven asthmatic children had repeat determinations of theophylline pharmacokinetic measurements over three- to nine-month intervals." | 3.65 | Intrapatient variability in theophylline kinetics. ( Strunk, RC; Taussig, LM; Walson, PD, 1977) |
| "Simultaneous saliva and plasma theophylline levels in 12 chronic asthmatic children were measured by high pressure liquid chromatography following administration of a theophylline preparation." | 3.65 | Reliability of salivary theophylline as a guide to plasma theophylline levels. ( Cummins, LH; Galant, SP; Gillman, SA; Kozak, PP; Orcutt, JJ, 1977) |
| "Theophylline clearance was examined in 23 children with chronic asthma by administering constant intravenous infusions of theophylline until steady-state serum concentrations were documented." | 3.65 | Relationship of theophylline clearance to oral dosage in children with chronic asthma. ( Ginchansky, E; Weinberger, M, 1977) |
| "Prior assumptions of first-order elimination for theophylline were tested by administering theophylline by intravenous infusion at two dosage levels to 20 children with chronic asthma." | 3.65 | Dose-dependent kinetics of theophylline disposition in asthmatic children. ( Ginchansky, E; Weinberger, M, 1977) |
| "1 Ephedrine plasma levels have been measured in ten asthmatic patients given a singel dose of ephedrine hydrochloride (22 mg) along and in combination with theophylline and a barbiturate." | 3.65 | The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment. ( May, CS; Paterson, JW; Pickup, ME; Ssendagire, R, 1976) |
| "Previously published data of plasma concentrations and pharmacologic effects obtained after rapid intravenous injection and during constant rate intravenous infusion of theophylline in asthmatic children were analyzed pharmacokinetically to determine the relationship between effect on pulmonary function (improvement of forced expiratory volume in the first second) and drug level." | 3.65 | Pharmacokinetic analysis of the effect of theophylline on pulmonary function in asthmatic children. ( Koysooko, R; Levy, G, 1975) |
| "The broncholytic effect and plasma concentrations of theophylline in 10 asthmatic patients were studied for 8 hours after a single dose of 600 mg choline theophyllinate in press-coated 200 mg tablets." | 3.65 | Plasma level and broncholytic effect of choline theophyllinate after a single dose of a press-coated tablet formulation. ( Bülow, KB; Larsson, H; Leideman, T, 1975) |
| "In eight asthmatic patients, there was no change in the bronchodilator response to a single dose of ephedrine (22 mg) given alone or in a compound tablet, after treatment with ephedrine (11 mg three times a day) or one tablet three times a day for 2 weeks." | 3.65 | The acute and chronic bronchodilator effects of ephedrine in asthmatic patients. ( May, CS; Paterson, JW; Pickup, ME, 1975) |
| "The bioavailability of theophylline from formulations containing this drug alone and also in combination with phenobarbital and ephedrine has been studied in normal volunteers and asthmatic subjects." | 3.65 | Influence of formulation on bioavailability of theophylline. ( Domoradzki, J; Reed, CE; Sims, JA; Welling, PG, 1976) |
| "A group of ambulatory asthmatic children was studied with serum and salivary theophylline levels following a prescribed dose of a hydroalcoholic solution of theophylline to determine compliance." | 3.65 | Compliance of chronic asthmatics with oral administration of theophylline as measured by serum and salivary levels. ( Eney, RD; Goldstein, EO, 1976) |
| " This study was performed to compare the efficacy of inhaled corticosteroids (ICS) combined with slow-release theophylline (SRT) with that of double-dose ICS in asthma control, anti-inflammatory activity and safety." | 2.71 | Comparison of inhaled corticosteroid combined with theophylline and double-dose inhaled corticosteroid in moderate to severe asthma. ( Li, SP; Liao, XQ; Lin, KX; Qian, GS; Song, YX; Wang, CZ; Wang, Y; Zhao, ZQ; Zhuo, WL, 2005) |
| "The theophylline serum levels were determined by an ELISA method." | 2.71 | Pharmacokinetics of theophylline after administration of suppositories formulation. ( Abou-Basha, LI; Aboul-Enein, HY; Hamza, A; Wahman, LF, 2005) |
| "Bronchial asthma is eosinophilic airway inflammation with enhanced airway responsiveness induced by eosinophilic granule proteins such as eosinophilic cationic protein (ECP) that are released from eosinophils." | 2.70 | [Effects of once-daily low-dose administration of sustained-release theophylline on airway inflammation and airway hyperresponsiveness in patients with asthma]. ( Terao, I, 2002) |
| " Following individual dosing of 100-300 mg theophylline twice a day, a pharmacokinetic profile for 24 h was derived after seven days of multiple dosing." | 2.69 | [Pharmacokinetics of theophylline in sustained-release formulation in young asthmatics]. ( Fuchs, WS; Heese, U; Laicher, A; von Nieciecki, A; Witschital, K, 1998) |
| "Histamine challenges were carried out by tidal breathing method at entry, and at Days 4, 8, 22, 36, and 40." | 2.69 | Effects of theophylline on tolerance to the bronchoprotective actions of salmeterol in asthmatics in vivo. ( Cheung, D; de GOEIJ, JA; de GRAAFF, CS; Steen, H; Sterk, PJ; Wever, AM, 1998) |
| " The pharmacokinetic characteristics of Xanthium were compared with those of Theo-Dur in twelve Thai children with stable persistent asthma by randomized, double blind, crossover study." | 2.69 | Comparative study of the pharmacokinetic characteristics of slow release theophylline oral preparations in Thai children with persistent asthma. ( Jiraporncharoen, K; Kanthawatana, S; Tontayapiwat, A; Trakultivakorn, M, 1999) |
| " In Ex I and II, no subjects had adverse effects and in Ex I no influence on ECG was seen." | 2.69 | Usefulness and safety of theophylline injection form (Theodrip) for the treatment of acute asthma. ( Fukui, H; Katoh, H; Kawai, H; Kojima, J; Ohnishi, A; Onodera, K; Taniguchi, T, 2000) |
| "To investigate the effect of small dose of oral theophyllin combined with low dose of inhaled beclomethasone dipropionate (BDP) on clinical symptoms, bronchial responsiveness and hypothalamic-pituitary-adrenal axis (HPAA)." | 2.69 | [Effect of low dose of inhaled corticosteroid combined with small dose of oral theophylline on treatment of bronchial asthma]. ( Huang, H; Li, J; Mo, H, 2000) |
| " Patients (n = 133) first received open-label Theo-Dur treatment with dosage titrated to achieve peak serum theophylline concentrations of 10-20 micrograms/ml." | 2.68 | Conversion from twice- to once-daily extended-release theophylline treatment in patients with reversible airway obstruction. ( Berkowitz, RB; Hubbard, RC; Lorber, RR; Marcoux, JP; Moss, BA; Rennard, SI; Rooklin, AR; Tinkelman, DG; Zeitz, HJ, 1995) |
| "Theophylline may produce a paradoxical increase in awareness of asthma in some individuals." | 2.68 | Influence of treatment with beclomethasone, cromoglycate and theophylline on perception of bronchoconstriction in patients with bronchial asthma. ( Higgs, CM; Laszlo, G, 1996) |
| "aminophylline did not produce adequate serum theophylline concentrations or eliminate the need for a second bolus dose in most pediatric patients with acute exacerbations of asthma." | 2.67 | Adequacy of recommended aminophylline loading doses in children. ( Godley, PJ; Maxwell-Rubin, M; Paap, CM, 1994) |
| " An one-compartment open pharmacokinetic model with first-order absorption and first-order elimination was used." | 2.67 | [Evaluation of theophylline population pharmacokinetics in adult hospitalized patients using NONMEM analysis]. ( Chen, G; Li, Z, 1994) |
| "The ketotifen dosage was 0." | 2.67 | Multicenter study with ketotifen (Zaditen) oral drop solution in the treatment of wheezy children aged 6 months to 3 years. ( Rotchild, M; Schlessinger, M; Soferman, R; Tabachnik, E; Tal, A; Varsano, I; Volovitz, B, 1993) |
| "This study was undertaken to determine if a computerized pharmacokinetic program for adjusting theophylline infusion rates could attain a goal serum theophylline level more accurately than physician-derived adjustments and what clinical impact this would have." | 2.67 | A randomized controlled trial of computerized pharmacokinetic theophylline dosing versus empiric physician dosing. ( Casner, PR; Ho, H; Reilly, R, 1993) |
| " To determine whether a calibrated dosage of oral slow-release theophylline inhibits asthmatic reactions and the associated increase of airway responsiveness to methacholine induced by TDI, we examined six asthmatic subjects who developed a late or a dual asthmatic reaction after TDI inhalation challenge." | 2.67 | Theophylline inhibits late asthmatic reactions induced by toluene diisocyanate in sensitised subjects. ( Boschetto, P; Ciaccia, A; Crescioli, S; De Marzo, N; Fabbri, LM; Mapp, CE; Plebani, M; Spinazzi, A, 1992) |
| "In order to determine the effects of repeated administration under fed and fasting conditions on the bioavailability and clinical efficacy of Uniphyl tablets, 22 adult asthmatics took the drug immediately following their evening meal for seven consecutive days and under fasting conditions for an additional seven consecutive days." | 2.67 | Repeated dosing of Uniphyl tablets under fed and fasting conditions: comparison of serum theophylline levels, pulmonary function, and asthma symptoms. ( Arkinstall, WW; Brar, PS; Stewart, JH, 1991) |
| "Theophylline (TPh) was absorbed from TP tablets according to the laws of the kinetics of the first order, i." | 2.67 | [The clinical efficacy and pharmacokinetic characteristics of theopek and theobiolong in bronchial asthma patients]. ( Abazova, FI; Belousov, IuB; Bondarenko, GP; Didkovskiĭ, NA; Kablashova, NA; Kholodov, LE; Kozhanov, AM; Noreĭka, RM, 1991) |
| "Theophylline was initially prescribed and monitored in an 'open' phase to obtain the drug dosage required to achieve a serum level in the therapeutic range of 10-20 mg/l." | 2.67 | The effect of sustained-release theophylline in nocturnal asthma. ( Cayton, RM; Freeman, W; Packe, GE, 1991) |
| "Theophylline was prescribed (10 mg." | 2.67 | Manufacturer's information insert and subjective theophylline side-effects. ( Faraj, F; Orehek, J; Razzouk, H; Toumi, M; Vesco, D, 1990) |
| "treatment." | 2.67 | High-dose inhaled versus intravenous salbutamol combined with theophylline in severe acute asthma. Swedish Society of Chest Medicine. ( , 1990) |
| "Theophylline was titrated for patients to receive, unblinded, theophylline serum concentrations of 10 to 20 micrograms/ml." | 2.67 | Long-term, double-blind comparison of controlled-release albuterol versus sustained-release theophylline in adolescents and adults with asthma. ( Bell, TD; LaForce, CF; MacCosbe, PE; Pierson, WE; Sykes, RS; Tinkelman, D, 1990) |
| "05 for both), there was no difference in methacholine sensitivity at the time of ingestion of the two dosage forms." | 2.67 | Relationship of different serum levels of theophylline on methacholine sensitivity. ( Garcha, BS; Lutz, CN; Tinkelman, DG, 1990) |
| " In contrast, the OD treatment was associated with larger peak-to-trough drug level fluctuation, with higher levels produced overnight and lower ones in the evening at the end of the dosing interval." | 2.67 | Twenty-four hour lung function in adult patients with asthma. Chronoptimized theophylline therapy once-daily dosing in the evening versus conventional twice-daily dosing. ( D'Alonzo, GE; Emerson, MB; Feldman, S; Gianotti, LA; Smolensky, MH; Staudinger, H; Steinijans, VW, 1990) |
| " Home monitoring prevented unnecessary clinic visits in several instances when theophylline dosage adjustments were based on telephone reports from patients." | 2.67 | Home monitoring of theophylline levels: a novel therapeutic approach. ( Chandler, MH; Clifton, GD; Coons, SJ; Foster, TS; Louis, BA; Phillips, BA, 1990) |
| " Of the patients who were unable to stop taking theophylline, the Zaditen-and placebo-treated groups recorded average dosage reductions of 62% and 26%, respectively." | 2.66 | A Canadian multicenter study with Zaditen (ketotifen) in the treatment of bronchial asthma in children aged 5 to 17 years. ( Brown, CA; Chandra, RK; Ho, P; Hoogerwerf, PE; Kennedy, RJ; Knight, A; Langer, H; Milne, J; Moote, DW; Rackham, A, 1989) |
| " Two different sustained-release theophylline preparations were used to determine (1) if the serum theophylline concentrations (STC) depend on the type and dosing schedule of the preparation, (2) the relationship between STC and the circadian variations in asthma, and (3) the effect of STC on sleep quality and respiratory patterns during the night." | 2.66 | Circadian variations in theophylline concentrations and the treatment of nocturnal asthma. ( Ballard, RD; Cherniack, RM; Cicutto, LC; Goldenheim, PD; Martin, RJ, 1989) |
| "The pharmacokinetic mechanism of the theophylline-terbutaline interaction has been studied." | 2.66 | Increased theophylline clearance in asthmatic patients due to terbutaline. ( Garty, M; Ilfeld, DN; Mazar, A; Paul-Keslin, L; Rosenfeld, JB; Spitzer, S, 1989) |
| " It can be concluded from this study that nedocromil sodium is a safe and effective drug in the management of asthma." | 2.66 | A group comparative study of the safety and efficacy of nedocromil sodium (Tilade) in reversible airways disease: a preliminary report. ( Bewtra, AK; Bodman, SF; Chick, TW; Koepke, JW; Nair, N; Nathan, RA; Selner, JC; Storms, WW; Townley, RG; van As, A, 1986) |
| " To assess the safety and efficacy of Uniphyl tablets, an oral theophylline preparation formulated for once-daily dosing, in elderly patients with chronic airflow obstruction, we conducted a randomized, three-phase, double-blind crossover study comparing evening dosing with Uniphyl tablets, Theo-Dur tablets administered twice daily, and placebo." | 2.66 | Safety and efficacy of once-daily Uniphyl tablets compared with twice-daily Theo-Dur tablets in elderly patients with chronic airflow obstruction. ( Aitken, TL; Calcutt, L; Hodder, RV; Rivington, RN; Stewart, JH, 1988) |
| "The relative bioavailability of two slow-release theophylline formulations using bead-filled capsules." | 2.66 | Oral bioavailability of slow-release theophylline from unencapsulated beads in preschool children with chronic asthma. ( Harris, JB; Milavetz, G; Smith, GD; Vaughan, LM; Weinberger, MM, 1988) |
| "Theophylline was stopped 24 hours and other bronchodilators at least 8 hours before the study day." | 2.66 | A dose-response study of the bronchodilator action of azelastine in asthma. ( Bucholtz, GA; Kemp, JP; Meltzer, EO; Middleton, E; Newton, JJ; Orgel, HA; Perhach, JL; Spector, SL; Welch, MJ, 1987) |
| " As the dosing of the investigated SR-formulation is circadian rhythm adapted, the major part of the daily dose, namely 2/3, is affected by the change in time of administration." | 2.66 | Chrono-optimization of the time of evening administration with unequally divided twice-daily theophylline. ( Borner, K; Kunkel, G; Steinijans, VW, 1987) |
| "Eight diurnally active (approximately 0730-1100 hr) adults (41-61 yr) suffering from nocturnal asthma volunteered for a double-blind, cross-over randomized study of a once-daily dosing (600-900 mg/24 hr) of Armophylline (Rorer s." | 2.66 | Comparison of once-daily evening versus morning sustained-release theophylline dosing for nocturnal asthma. ( Abella, ML; Chaouat, D; Gervais, A; Gervais, P; Levi, F; Pauchet, F; Reinberg, A; Ruff, F; Smolensky, MH; Zidani, R, 1987) |
| ") dosage schedules--twice-daily equally divided 12 hr (BID), once-daily evening (OD-PM) and once-daily morning (OD-AM)--were compared under steady-state conditions in 10 adult asthmatics with a documented history of nocturnal dyspnea." | 2.66 | Comparison of sustained-release theophylline scheduled conventionally (twice-daily, equal interval in equal amount) versus once-daily mornings or evenings on circadian pattern of bronchial patency in asthmatics. ( D'Alonzo, GE; Frankoff, HM; Gianotti, L; Hsi, B; McGovern, JP; Smolensky, MH, 1987) |
| " The pharmacokinetics of Theo-24 varied greatly depending on the dosing time." | 2.66 | Administration-time-dependency of the pharmacokinetic behavior and therapeutic effect of a once-a-day theophylline in asthmatic children. ( Baenziger, JC; Harrist, RB; Hiatt, PH; Klank, BJ; Marbella, A; Meltzer, A; Scott, PH; Smolensky, MH; Wong, TK, 1987) |
| " A crossover study comparing the pharmacokinetic and clinical response to Theolan Suspension (administered every 12 hours) with aminophylline solution (administered every 8 hours) in children younger than 12 years of age is reported." | 2.66 | Clinical and pharmacokinetic evaluation of a sustained-release liquid theophylline preparation. ( Altman, RE; Bottini, PB; Brown, DA; DuRant, RH; Guill, MF; Lawless, TE; Pruitt, AW, 1988) |
| " This disparity reflects the greater bronchodilation effected by isoproterenol as a single agent than by epinephrine, in the dosing schedules and routes of administration chosen." | 2.66 | Treatment of acute asthma. Is combination therapy with sympathomimetics and methylxanthines indicated? ( Fanta, CH; McFadden, ER; Rossing, TH, 1986) |
| "Reproterol is a synthetic selective beta-adrenoceptor agonist with a xanthine side chain." | 2.66 | Bronchial and cardiovascular responses to inhaled reproterol in asthmatics: a double-blind placebo controlled dose-response study. ( Burge, PS; Patchett, P; Patchett, SM, 1985) |
| " single daily dosing with the 24-hour sustained-release theophylline Uniphyl." | 2.66 | Comparison of morning and evening dosing with a 24-hour sustained-release theophylline, Uniphyl, for nocturnal asthma. ( Bush, RK; Busse, WW, 1985) |
| ") dosing regimens with a new once-daily oral theophylline (Uniphyl, Purdue Frederick) was performed." | 2.66 | Comparison of morning versus evening dosing with a new once-daily oral theophylline formulation. ( Calcutt, L; Child, S; Hodder, RV; MacLeod, JP; Rivington, RN; Stewart, JH, 1985) |
| " The same dosage per kilogram for either preparation gave virtually identical mean serum levels suggesting there is no difference in the rate of absorption between the two preparations." | 2.65 | A comparative trial of two slow-release theophylline tablets in the treatment of asthma; Nuelin S.A. and Theocontin Continus tablets. ( Davies, BH; Davies, PD; Hakeem, V; Munn, J, 1984) |
| " Plasma levels from 5 to 20 mg/l were measured after five days of treatment with either preparation given in average dosage of 10 mg Theophylline per kg body weight." | 2.65 | [Comparison of 2 theophylline delayed-action preparations of different galenic forms]. ( Hirsch, H, 1983) |
| "Theophylline serum levels were measured by radioimmunoassay." | 2.65 | [Therapy of obstructive respiratory tract diseases with pure theophylline retard]. ( Arens, PJ, 1982) |
| " Ten asthmatic children who reported a feeling of chest tightness and subsequent wheezing after taking a preparation containing brompheniramine maleate were studied in addition to 10 control asthmatic children who reported no such adverse effect." | 2.65 | Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children. ( Schuller, DE, 1983) |
| " Both dosage forms appeared to have similar kinetic properties within the context of the study." | 2.65 | Bioavailability, efficacy, and tolerance of two sustained-release theophylline dosage forms in adult patients with bronchial asthma. ( Demers, L; Esler, V; Field, E; Trautlein, JJ, 1981) |
| "Inflammation is a central feature of asthma and chronic obstructive pulmonary disease (COPD)." | 2.61 | Transcription inhibitors and inflammatory cell activity. ( Adcock, IM; Cannavò, MF; Caramori, G; Coppolino, I; Mumby, S; Nucera, F; Proietto, A; Ruggeri, P, 2019) |
| "Bronchial asthma is a chronic inflammatory disorder of the airways associated with airflow obstruction that is reversible spontaneously or with treatment." | 2.48 | Chronotherapeutics--a chronopharmaceutical approach to drug delivery in the treatment of asthma. ( Nainwal, N, 2012) |
| "Chronic obstructive pulmonary disease (COPD) and asthma are chronic diseases that are increasing worldwide in incidence, prevalence, and burden." | 2.44 | Differentiating chronic obstructive pulmonary disease from asthma. ( Balkstra, CR; Buchsel, PC; Kuebler, KK, 2008) |
| " Dosage recommended for children> 6 yrs of age is 6 mg/Kg/dose BID." | 2.44 | Doxofylline: The next generation methylxanthine. ( Kabra, SK; Lodha, R; Sankar, J, 2008) |
| " Older people experience more adverse drug effects because of pharmacodynamic and pharmacokinetic changes and particularly drug-drug and drug-disease interactions." | 2.44 | Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribing. ( Gupta, P; O'Mahony, MS, 2008) |
| " In the meantime, health care providers and pregnant women must work with the information that is available to evaluate the risks and benefits of a particular medication and alternative choices for treatment of asthma or allergy during pregnancy, while considering the potential for adverse effects if the woman with severe or uncontrolled asthma is under-treated." | 2.43 | Safety of asthma and allergy medications in pregnancy. ( Chambers, C, 2006) |
| "Inflammatory lung diseases are characterised by increased expression of multiple inflammatory genes that are regulated by proinflammatory transcription factors, such as NF-kappaB." | 2.43 | Histone deacetylation: an important mechanism in inflammatory lung diseases. ( Adcock, IM; Barnes, PJ; Ito, K, 2005) |
| "Theophylline has also been used in the treatment of patients with asthma, although there is a perception that this drug does not offer the patient any advantages over conventional therapeutic strategies." | 2.42 | Theophylline and PDE4 inhibitors in asthma. ( Spina, D, 2003) |
| "Epidemiological studies showed that bronchial asthma is one of the most common diseases which can complicate pregnancy (1-7%)." | 2.42 | General strategy for the management of bronchial asthma in pregnancy. ( Canonica, GW; Cazzola, M; D'Amato, G; D'Amato, M; Liccardi, G; Passalacqua, G, 2003) |
| "With very few exceptions, COPD is caused by tobacco smoking, and smoking cessation is the only truly effective treatment of COPD available." | 2.42 | Pharmacology of airway inflammation in asthma and COPD. ( Adcock, I; Caramori, G, 2003) |
| "Prevalence of gastroesophageal reflux had been detected in 24% of asthmatic patients, in some cases as a cause of asthma exacerbation." | 2.42 | [Treatment of bronchial asthma exacerbation]. ( Płusa, T, 2004) |
| "The goal of management of patients with respiratory failure is to restore them to a state of quiet breathing, without complication." | 2.41 | Management of respiratory failure in patients with asthma. ( Corbridge, T; Gluckman, TJ, 2000) |
| " Alongside concerns about long term use of ICS and possible systemic adverse effects, there remains a need for alternative approaches to the control of the disease in children." | 2.41 | Corticosteroid-sparing options in the treatment of childhood asthma. ( Helms, PJ, 2000) |
| "Aminophylline has not been found by most studies to improve outcomes and the narrow therapeutic range and unfavorable safety profile relegate it to a last-line agent or no use at all." | 2.41 | Treatment of acute asthma. A new look at the old and at the new. ( Silverman, R, 2000) |
| " They can be used to study the dose-response effect of inhaled corticosteroids and may be useful to establish the relative potency of different corticosteroid formulations and delivery devices." | 2.41 | The use of sputum cell counts to evaluate asthma medications. ( Hargreave, FE; Parameswaran, K, 2001) |
| "Inhaled corticosteroid therapy against bronchial asthma has developed rapidly and remarkably during last 10 years." | 2.41 | [Recent advance in inhaled corticosteroid therapy]. ( Hojo, M; Kudo, K, 2001) |
| " Inhaled corticosteroids (ICS), because of their efficacy, remain a cornerstone in managing persistent pediatric asthma, but also are associated with significant adverse effects, including growth suppression." | 2.41 | Balancing safety and efficacy in pediatric asthma management. ( Skoner, DP, 2002) |
| " Two recently completed trials have demonstrated that with respect to asthma control the combination of inhaled steroid (400 - 800 microg/d) plus theophylline is at least as effective as doubling the dose of inhaled steroid in patients who remain symptomatic on a dosage of 400 - 800 microg daily." | 2.40 | [Asthma therapy: combination of topical glucocorticosteroids and theophylline]. ( Ukena, D, 1997) |
| "Theophylline is a bronchodilator that is useful for severe and nocturnal asthma, but recent studies suggest that it may also have an immunomodulatory effect." | 2.40 | Current therapies for asthma. Promise and limitations. ( Barnes, PJ, 1997) |
| "Theophylline, a drug that has been used for several decades, has several different actions at a cellular level, including inhibition of phosphodiesterase isoenzymes, antagonism of adenosine, enhancement of catecholamine secretion, and modulation of calcium fluxes." | 2.40 | Theophylline: recent advances in the understanding of its mode of action and uses in clinical practice. ( Lipsky, JJ; Vassallo, R, 1998) |
| " Compliance with therapy in adolescents in particularly low if the dosing regimen is more than twice daily, with poor inhaler technique contributing to ineffective control." | 2.40 | The problems of treating adolescent asthma: what are the alternatives to inhaled therapy? ( Kemp, J; Price, J, 1999) |
| "Theophylline has a narrow therapeutic margin." | 2.39 | Pharmacokinetic optimisation of asthma treatment. ( Schmit, B; Taburet, AM, 1994) |
| "Although bronchial asthma is the most frequent chronic disease in childhood, not all of the affected children are readily recognised as asthmatics well in time for appropriate treatment." | 2.38 | [Treatment strategy in childhood bronchial asthma]. ( Schuster, R; Sollich, V; Thal, W, 1993) |
| " Because of recent concerns raised in the literature about the safety of long-term use of beta 2 agonists, early and appropriate medication in the form of inhaled corticosteroids or cromolyn sodium is recommended for daily control of asthma symptoms, long-term patient management, and prevention of acute exacerbations." | 2.38 | Asthma in the 1990s. A new approach to therapy. ( Busse, W, 1992) |
| "Theophylline, a drug which has been used in asthma therapy for many years, provides additional benefit for patients already treated with effective doses of beta-agonists and/or corticosteroids." | 2.38 | Asthma--something old, something new .... ( Milgrom, H, 1991) |
| " Once-daily theophylline when dosed in the evening not only controls nocturnal symptoms and improves airflow during the early morning hours, but decreases airway responsiveness to histamine as well." | 2.38 | Nocturnal asthma: mechanisms and the role of theophylline in treatment. ( Bush, RK, 1991) |
| " The investigations--in most cases estimations of the nonbiotransformated part of antituberculotic drugs and theophylline had following purposes: security of the necessary dose especially in the case of INH (hereditary INH-polymorphismus), proof of a sufficient permeation of INH and RMP in the tuberculous kidney, control of the usefulness or uselessness of the INH-depot-preparations, relations between the concentration in the serum and dose respectively of the appearance of side effects, estimation of bioavailability and pharmacokinetic parameters during the development of an useful retard-preparation of theophylline." | 2.38 | [Clinical pharmacology in optimization of therapy of lung diseases]. ( Iwainsky, H; Wiesner, B; Winsel, K, 1991) |
| " Ultimately the pharmacologic modulation of the pathologic features of the asthmatic airway by the chronic use of antiasthma drugs, coupled with clinical responses, need to be investigated using bronchial biopsies and broncholveolar lavage in asthmatic patients." | 2.38 | Pharmacology of airway inflammation in asthma. ( Chung, KF, 1990) |
| "Theophylline's role in the treatment of airway obstruction has been challenged, yet it remains a useful agent in the management of obstructive lung disease." | 2.38 | Theophylline in asthma and COPD: changing perspectives and controversies. ( Poe, RH; Utell, MJ, 1991) |
| "Theophylline concentrations in serum between 10 to 20 micrograms/ml cannot be obtained with usual dosage of theophylline in children with individual very short elimination half time of theophylline." | 2.38 | [Individually-adjusted dosages of aminophylline in children with bronchial asthma]. ( Feller, K; Gramatté, T; Leupold, W; Paditz, E; Richter, K, 1990) |
| "Theophylline is a second-line drug for the symptomatic treatment of obstructive pulmonary diseases." | 2.38 | Management of chronic airway obstruction: theophylline--is it still necessary? ( Sybrecht, GW; Ukena, D, 1990) |
| " Dosing practices that will minimize side effects and toxicity are stressed, along with their management if they do occur." | 2.37 | Theophylline use in asthma. Some current issues. ( Jenne, JW, 1984) |
| " When chronic symptoms necessitate maintenance treatment, the frequency of dosing may become a deciding factor in the selection of a bronchodilator." | 2.37 | Tulobuterol in the management of obstructive airways disease in adults. ( Patel, KR, 1985) |
| "The various features of bronchial asthma as it pertains to infants and children are reviewed." | 2.37 | Asthma in infants and children--treatment of childhood asthma: Part II. ( Rachelefsky, GS; Siegel, SC, 1985) |
| "Gastroesophageal reflux (GER) and its many manifestations are extremely common problems." | 2.37 | Respiratory complications of gastroesophageal reflux. ( Barish, CF; Castell, DO; Wu, WC, 1985) |
| " Initial findings from studies of unequal (morning versus evening) BID dosing schedules--more theophylline or terbutaline before bed-time than arising--reveal a better therapeutic advantage relative to equal BID dosing schedules for those patients with predominantly nocturnal symptoms." | 2.37 | Chronobiology and asthma. II. Body-time-dependent differences in the kinetics and effects of bronchodilator medications. ( McGovern, JP; Reinberg, A; Scott, PH; Smolensky, MH, 1987) |
| "Enprofylline is a more potent smooth muscle relaxant and antiasthmatic drug than theophylline but does not produce, e." | 2.37 | Effects of enprofylline and theophylline may show the role of adenosine. ( Andersson, KE; Kjellin, G; Persson, CG, 1986) |
| " The required higher dosage in relation to body weight results in more pronounced oscillations of drug levels in serum." | 2.37 | [Peculiarities of theophylline therapy in childhood]. ( Köhler, E; Schuster, R; Sollich, V; Thal, W; Walther, H, 1988) |
| " In steady-state we did the pharmacokinetic studies at 1 h, 4 h and 6 h after the administration of one dose." | 2.37 | [Pharmacokinetics of theophylline in children with acute asthmatic crisis]. ( Casasín Edo, T; Closa Monasterolo, R; Gómez Papi, A; Llusa Arbos, M; Tarrés Roure, A, 1988) |
| "The theophylline title is a very important biologic parameter, necessary to the asthma treatment survey through such drug." | 2.37 | [Significance and evaluation of theophyllinemia in clinical medicine]. ( Beziau, H; Blaive, B; Bonnaud, F; Bugnas, B; Fournier, JP; Lemoigne, F, 1986) |
| "Selection of the dosing interval for oral theophylline must consider the product's absorption rate, the patient's elimination rate, and the tolerated fluctuation in serum concentration." | 2.37 | Clinical and pharmacokinetic concerns of 24-hour dosing with theophylline. ( Weinberger, M, 1986) |
| "Bronchial asthma is not a disease entity but a nonspecific reaction of the lung characterized by recurrent reversible airway obstruction." | 2.36 | [Bronchial asthma. Long-term therapy and prognosis]. ( Rieger, CH, 1983) |
| " Careful dosage titration prevents adverse effects, especially when final dosage is guided by measurement of serum concentration." | 2.36 | Theophylline for chronic asthma: rationale for treatment, product selection, and dosage schedule. ( Hendeles, L; Weinberger, M, 1983) |
| "The bronchial asthma is a polyetiologic syndrome with increased bronchomotoric excitability." | 2.36 | [New viewpoints in the pathogenesis and therapy of bronchial asthma]. ( Jäger, L, 1979) |
| "Adult bronchial asthma (hereinafter, asthma) is characterized by chronic airway inflammation, reversible airway narrowing, and airway hyperresponsiveness." | 1.40 | Japanese Guideline for Adult Asthma 2014. ( Adachi, M; Akiyama, K; Ichinose, M; Nagase, H; Ohta, K; Sugiura, H; Tohda, Y; Yamaguchi, M; Yamauchi, K, 2014) |
| "We analyzed COPD subjects with GOLD I-IV disease in the COPDGene® study." | 1.38 | Demographic, physiologic and radiographic characteristics of COPD patients taking chronic systemic corticosteroids. ( Criner, GJ; Kim, V; Make, BJ; Murphy, JR; Newell, J; Satti, A; Silverman, EK; Steiner, RM; Swift, I; Wilson, C, 2012) |
| "The Spanish COPD Guidelines (GesEPOC) is an initiative of SEPAR, which, together with the scientific societies involved in COPD patient care, and the Spanish Patient Forum, has developed these new clinical practice guidelines." | 1.38 | Spanish COPD Guidelines (GesEPOC): pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery. ( Almagro, P; Ancochea, J; Calle, M; López-Campos, JL; Miravitlles, M; Molina, J; Piñera, P; Quintano, JA; Riesco, JA; Simón, A; Soler-Cataluña, JJ; Soriano, JB; Trigueros, JA, 2012) |
| "The prepared immediate release and controlled release pastilles were subjected to in vivo pharmacokinetic studies in rats." | 1.38 | Evaluation of in vivo behavior of controlled and pulsatile release pastilles using pharmacokinetic and γ-scintigraphic techniques. ( Chakraborty, S; Mishra, B; Shukla, D, 2012) |
| "Melatonin treatment strengthened contraction responses, but did not affect relaxation responses in rat tracheal preparations." | 1.38 | The achilles heel in melatonin: asthma. ( Belgin Yildirim, F; Karasu-Minareci, E; Kaya, Y, 2012) |
| "Theophylline pellets were optimized by applying a 2-factors 3-levels full factorial design." | 1.36 | Development of colon targeted multiparticulate pulsatile drug delivery system for treating nocturnal asthma. ( Gattani, SG; Kadam, VD, 2010) |
| " A risk simulation platform that integrates population statistics, drug delivery system characteristics, dosing guidelines, patient compliance estimates, production metrics, and pharmacokinetic, pharmacodynamic, and in vitro-in vivo correlation models to investigate the impact of manufacturing variability on clinical performance of a model extended-release theophylline solid oral dosage system was developed." | 1.36 | A new definition of pharmaceutical quality: assembly of a risk simulation platform to investigate the impact of manufacturing/product variability on clinical performance. ( Anderson, CA; Cogdill, RP; D'Amico, F; Drennen, JK; Short, SM, 2010) |
| " Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants." | 1.35 | Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients. ( Igarashi, T; Iwakawa, S, 2009) |
| "Theophylline microspheres were prepared by solvent evaporation method using Eudragit S 100." | 1.35 | Development and evaluation of pulsatile drug delivery system using novel polymer. ( Gattani, SG; Tekade, AR, 2009) |
| "The theophylline microcapsules were prepared in four batches, with Eudragit L-100 and S-100 (1:2) by varying drug to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and from the obtained results; one better formulation was selected for further fabrication of pulsatile capsule." | 1.34 | Time and pH dependent colon specific, pulsatile delivery of theophylline for nocturnal asthma. ( Dandagi, PM; Gadad, AP; Jain, SS; Kulkarni, AR; Mastiholimath, VS, 2007) |
| "Concomitant GERD was revealed in 45." | 1.33 | [Gastroesophageal reflux disease and respiratory apparatus pathology: the evidence of interrelation and unsolved problems]. ( Chereĭskaia, NK; Isakov, VA; Ivanova, OV; Paleev, NR, 2005) |
| " All patients received inhaled corticosteroids; only 44 had high dosed corticosteroids." | 1.33 | [Treatment compliance in asthma: a Tunisian transversal study]. ( Ali, BK; Ikram, D; Radhouane, F; Sonia, M, 2005) |
| "The lifetime prevalence of bronchial asthma in adults is approximately 5%." | 1.33 | [Drug therapy of asthma. Results of the 1998 German National Health Interview and Examination Survey]. ( Knopf, H; Langen, U; Melchert, HU, 2006) |
| ", its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i." | 1.32 | An evaluation of population D-optimal designs via pharmacokinetic simulations. ( Dodds, MG; Foracchia, M; Hooker, AC; Vicini, P, 2003) |
| "Theophylline has been widely used in the treatment of bronchial asthma mainly due to its bronchodilating effect." | 1.32 | Theophylline attenuates the adhesion of eosinophils to endothelial cells. ( Choo, JH; Kikuchi, I; Nagata, M; Sakamoto, Y; Sutani, A, 2003) |
| "The prevalence of bronchial asthma, similarly to the normal population, is also increasing among pregnant women." | 1.32 | [Treatment of bronchial asthma in pregnancy]. ( Bártfai, Z; Somoskövi, A; Tamási, L; Tolnay, E, 2003) |
| " These findings suggest that ways need to be found: (i) to increase the use of current asthma management guidelines by practitioners; (ii) to improve documentation of prescribed medications and their dosage and; (iii) to improve education of parents in home management measures." | 1.32 | Prescribing for asthmatic children in primary care. Are we following guidelines? ( Dashash, NA; Mukhtar, SH, 2003) |
| "Sixty-seven patients with bronchial asthma treated with the bronchodilator insanovin for 4 weeks were followed up." | 1.32 | [Insanovin aerosol therapy in the treatment of bronchial asthma]. ( Insanov, AB; Mustafaeva, LI, 2004) |
| "GERD was present in 86." | 1.32 | [Prevalence of gastroesophageal reflux disease in patients with bronchial asthma]. ( Bocheńska-Marciniak, M; Górski, P, 2004) |
| "inhibition: 97." | 1.32 | Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients. ( Beeh, KM; Beier, J; Buhl, R; Lerch, C; Schulz, AK, 2004) |
| "The theophylline-treated and CK-elevating drug-treated group showed about 100% higher serum CK levels (225 IU/L) than any other group (102-124 IU/L), and no increase in the serum theophylline level." | 1.31 | Synergistic effect of combining theophylline and drugs that potentially elevate serum creatine kinase. ( Iwano, J; Izumida, T; Minakuchi, K; Nakamura, Y; Sone, S; Takiguchi, Y; Yokota, M, 2000) |
| " Experimental studies in pregnant rabbits using Primatene in both low and high dosage resulted in limb reduction defects and other malformations in a significant number of the offspring compared with controls." | 1.31 | Association of sympathomimetic drugs with malformations. ( Drut, RM; Gilbert-Barness, E, 2000) |
| " On the basis of a continuous dose-response analysis, we calculated that the rate of death from asthma decreased by 21 percent with each additional canister of inhaled corticosteroids used in the previous year (adjusted rate ratio, 0." | 1.31 | Low-dose inhaled corticosteroids and the prevention of death from asthma. ( Baltzan, M; Benayoun, S; Cai, B; Ernst, P; Suissa, S, 2000) |
| "Treatment with theophylline significantly increased FEV1 (3." | 1.31 | [The effect of 6 week treatment with theophylline on spirometric parameters, nonspecific bronchial reactivity and the concentration of soluble interleukin 2 receptor in serum of asthmatic patients]. ( Chazan, R; Droszcz, W; Grubek-Jaworska, H; Mazurek, J; Wrońska, J, 2000) |
| " Then a sustained-release theophylline preparation formulated for once-daily dosing was administered to these patients grouped to examine the effect of the drug on circadian rhythms in PEF." | 1.31 | [Chronotherapy of bronchial asthma: circadian rhythms in peak expiratory flow. The report II: Circadian rhythms of peak expiratory flow in asthmatic patients and effect of sustained-release theophylline on various types of the circadian rhythms]. ( Kagami, M; Nakazawa, T; Tomioka, H; Yoshida, S, 2001) |
| "Steady-state bioavailability of sustained-release theophylline (SRT); Theo-Dur, Uni-Dur and Xanthium were compared in 10 healthy males with theophylline clearance ranged from 0." | 1.31 | Comparative steady-state bioavailability of sustained-release theophylline preparations: Theo-Dur, Uni-Dur and Xanthium. ( Kovjiriyapan, K; Manorot, M; Pothirat, C; Rojanasthien, N, 2001) |
| "Aminophylline 25 mg/kg was given intraperitoneally to the group I animals and 5 mg/kg to group II animals." | 1.31 | Pulmonary function changes and immunomodulation of Th 2 cytokine expression induced by aminophylline after sensitization and allergen challenge in brown Norway rats. ( Chen, A; Liaw, SF; Lin, CC; Lin, CY, 2002) |
| "terbutaline because of bronchoconstriction (dosage not documented)." | 1.30 | [Acute theophylline intoxication as differential diagnosis of pneumothorax in an asthma patient]. ( Schaarschmidt, S; Standl, T, 1997) |
| "Eosinophils play a crucial role in bronchial asthma." | 1.30 | Inhibitory effects of theophylline and procaterol on eosinophil function. ( Horie, S; Hossain, M; Isobe, M; Momose, T; Okubo, Y; Sekiguchi, M; Suzuki, J, 1997) |
| " The definition of equivalence acceptance limits becomes crucial, particularly in studies conducted in the flat range of the dose-response curve of inhaled steroids." | 1.30 | Asthma management: the challenge of equivalence. ( Hummel, T; Keller, A; Leichtl, S; Neuhäuser, M; Rathgeb, F; Steinijans, VW, 1998) |
| "Theophylline is an immunomodulator; however, weak effects and the narrow therapeutic window make it a controversial drug." | 1.30 | Differences in the anti-inflammatory effects of theophylline and pentoxifylline: important for the development of asthma therapy? ( Bitter-Suermann, S; Burdon, D; Entzian, P; Ernst, M; Schlaak, M; Zabel, P, 1998) |
| " This question is more relevant to the chronic use of the long-acting beta2-agonists, salmeterol and formoterol." | 1.30 | Options for bronchodilation in children: can we rely on adult data? ( Verberne, AA, 1999) |
| " The one-compartment model as a pharmacokinetic model was assumed." | 1.30 | [Population pharmacokinetic analysis of theophylline: relationship between serum concentrations and clinical effects in therapeutic drug monitoring]. ( Fukuoka, M; Goshima, T; Matsumoto, M; Matsumoto, Y; Matsuzaki, T; Noguchi, S; Tanikawa, K, 1999) |
| "The long-term treatment modalities of bronchial asthma were studied in children from a defined Finnish population from 1985 to 1993, with special reference to changes during the study period." | 1.29 | Preventive therapy for asthma in children; a 9-year experience in eastern Finland. ( Korppi, M; Kuikka, L; Remes, K, 1995) |
| " Percentage of dosage of beta 2 adrenergics inhaled as against the total of beta 2 (oral and inhaled)." | 1.29 | [Evaluation of the impact of a care program for asthmatic children on the quality of anti-asthma drug prescriptions]. ( Alba, F; Gimeno, J; González, M; Madridejos, R, 1995) |
| " In the resting state, the chronic administration of theophylline seemed to produce a slight increase in percent fractional shortening, outflow peak velocity and atrial contribution to ventricular filling in the asthmatic children as compared to normals, but these changes were not statistically significant." | 1.29 | Left ventricular function in asthmatic children chronically treated with theophylline evaluated by exercise Doppler echocardiography. ( Aoki, T; Hayashi, H; Iwase, M; Miyaguchi, K; Watanabe, T; Yokota, M, 1994) |
| "Mixed atrial and ventricular arrhythmias, which are rarely mentioned as a specific feature of theophylline intoxication, were found in 16% of our patients and accounted for 29% of the cardiovascular manifestations." | 1.29 | The clinical implication of theophylline intoxication in the Emergency Department. ( Chern, TL; Deng, JF; Hu, SC; Lee, CH; Tsai, J; Wang, RB, 1994) |
| "We studied the design of oral sustained-release theophylline dosing after conversion from constant aminophylline infusion." | 1.29 | The design of oral sustained-release theophylline dosing after conversion from intravenous to oral therapy. ( Agata, H; Fukutomi, O; Imaeda, N; Kato, Z; Kondo, N; Kondo, T; Nakashima, Y; Orii, T; Shinoda, S; Yamazaki, M, 1994) |
| "Drug treatment of bronchial asthma should be initiated early on, be planned for the long-term, and comprise an individually matched combination of anti-inflammatory agents and drugs with an acute action." | 1.29 | [Bronchial asthma in childhood. Part 2: Prevention and step-wise plan for drug therapy]. ( Nicolai, T; Oberbauer, B; von Mutius, E, 1993) |
| "preparation in the treatment of bronchial asthma in childhood." | 1.29 | [Preliminary evaluation of efficacy for the preparation DNCG-compositum in treatment of atopic bronchial asthma in children]. ( Boznański, A; Domanasiewicz, M; Pirogowicz, I; Rudzka, D, 1994) |
| " We report the case of a 44-year-old woman who presented with toxic effects of theophylline secondary to the use of an over-the-counter product for asthma." | 1.29 | Theophylline toxic effects from an over-the-counter asthma medication. ( Purdom, D; Scarpinato, L, 1993) |
| "In order to study risk factors for gastroesophageal reflux (RGO), we have analysed the clinical particulars, the spirometry and the different therapies of chronic asthmatics with and without RGO." | 1.29 | [Risk factors for gastroesophageal reflux in chronic asthma]. ( Charlery, S; Denjean, A; Duroux, P; Escourrou, P; Gandolfo, JY; Gaultier, C; Hervé, P; Petitpretz, P; Salmeron, S; Simonneau, G, 1993) |
| "The effects and the mechanism of single and long-term administration of theophylline on ventilatory regulation were investigated in patients with chronic obstructive pulmonary disease (COPD)." | 1.29 | [Effects of theophylline on ventilatory regulation in patients with chronic obstructive pulmonary disease]. ( Aritomi, T; Ikeda, A; Ishibashi, M; Miyahara, S; Senju, S; Toyoshima, H; Watanabe, K; Yoshida, M, 1993) |
| "In 38 patients with atopic bronchial asthma DNCG (disodium cromoglycate) and DNCG comp." | 1.29 | [Clinical evaluation of disodium cromoglycate with beta-2-agonist in therapy of patients with atopic bronchial asthma (preliminary study)]. ( Chciałowski, A; Mamełka, B; Płusa, T; Włodarczyk, R, 1993) |
| " For 10 patients this method definitely revealed non-compliance, whereas compliance was doubtful with 12 children and 15 children had strictly adhered to the prescribed dosage regimen." | 1.29 | [Compliance of children with bronchial asthma in long-term therapy with theophylline retard preparations]. ( Köhler, E; Schuster, R; Sollich, V, 1993) |
| "Since surgery, bronchial asthma has been effectively controlled with standard drug therapy in all patients." | 1.29 | Surgical therapy for Wolff-Parkinson-White syndrome in patients with bronchial asthma. ( Kawasuji, M; Matsunaga, Y; Misaki, T; Ohtake, H; Tubota, M; Watanabe, Y, 1996) |
| "Treatment with rolipram, but not theophylline, prevented the increase in responsiveness to inhaled histamine 24 h after antigen challenge." | 1.29 | Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits. ( Blake, SM; Gozzard, N; Herd, CM; Higgs, GA; Holbrook, M; Hughes, B; Page, CP, 1996) |
| " Population pharmacokinetic analysis was performed with the MULTI(ELS) computer program according to a one-compartment model." | 1.29 | Application of population pharmacokinetics to the optimization of theophylline therapy. ( Barrueco, M; Buelga, DS; Dominguez-Gil, A; Otero, MJ; Vázquez, MA, 1996) |
| " With this dosage the median values of the 24-hour profile (10." | 1.29 | [Inhibition of growth hormone secretion by theophylline in asthmatic children]. ( Baum, WF; Klöditz, E; Schneyer, U, 1996) |
| " Dosage was according to age between 11 and 24 mg/kg body weight and day." | 1.29 | [Comparison of serum concentrations of once and twice daily administration of ultra-retard theophylline in school children with bronchial asthma]. ( Liebke, C; Niggemann, B; Wahn, U, 1996) |
| " Some of these agents have narrow therapeutic ranges and are associated with potentially serious adverse reactions, toxic effects, or drug interactions." | 1.29 | Possible theophylline toxicity during anesthesia. ( Redden, RJ, 1996) |
| " However, the pharmacokinetic interaction between mexiletine and theophylline has not been clarified." | 1.28 | [The effect of mexiletine on theophylline pharmacokinetics in patients with bronchial asthma]. ( Hariya, Y; Hayakawa, H; Inafuku, M; Nagasawa, K; Nakahara, Y; Ohtsu, F; Suzuki, T; Yoshioka, Y, 1992) |
| "Theophylline concentration was determined using HPLC." | 1.28 | Could saliva stand for plasma in theophylline monitoring in asthmatic children? Still a controversial problem. ( Bertin, L; d'Athis, P; de Blic, J; Gao, Y; Olive, G; Pons, G; Rey, E; Richard, MO; Scheinmann, P; Thiroux, G, 1992) |
| "for treatment of bronchial asthma." | 1.28 | A prospective trial using salivary-theophylline levels to guide asthma therapy. ( Mansfeld, J; Matthys, H; Virchow, C; Virchow, JC, 1992) |
| "To report unusually high theophylline dosing requirements in a smoker receiving concomitant therapy with phenytoin and phenobarbital." | 1.28 | Massive theophylline dosing in a heavy smoker receiving both phenytoin and phenobarbital. ( Basile, SA; Cury, JD; Nicholson, JP, 1992) |
| " After the patient recovered, a pharmacokinetic study demonstrated that normal methylxanthine metabolism was re-established." | 1.28 | Pharmacokinetics of theophylline and its metabolites during acute renal failure. A case report. ( Coates, PE; Elias-Jones, AC; Leakey, TE; Smith, KJ, 1991) |
| "00 hr) dosing was characterized by significantly low rate of absorption (t 1/2a and Tmax) but higher extent of absorption (AUC0-alpha) compared to that after nocturnal dosing (22." | 1.28 | A study on the chronopharmacokinetics of theophylline in rabbits. ( Chakrabarti, A; Garg, SK; Kumar, A, 1991) |
| "To assess the pharmacokinetic parameters of theophylline (Euphylong as retard pellets) children were studied belonging to age groups between 9 to 13 and 5 to 9 years in twice-daily dosage with unequal distribution of the daily doses." | 1.28 | [Pharmacokinetics and pharmacodynamics of twice-daily unequal administration of theophylline retard pellets in children of various age groups]. ( Berdel, D; Heimann, G; Reinhardt, D; Sauter, R; Steinijans, VW; von Berg, A, 1991) |
| " The general practice workload involved in adjusting theophylline dosage was approximately four consultations, one dose change and two serum assays per 'average' patient." | 1.28 | Clinical audit of theophylline use in general practice. ( McDevitt, DG; Neville, RG, 1991) |
| "The effects of long-term administration of theophylline on the pituitary-thyroid axis were investigated." | 1.28 | [Effects of long-term administration of theophylline on the pituitary-thyroid axis in asthmatics]. ( Fukutani, K, 1991) |
| "The theophylline syrup was as rapidly and as essentially bioavailable as the theophylline granule preparation." | 1.28 | [A comparative study of the pharmacokinetics and urinary metabolites of sustained-release theophylline syrup, granule and tablet preparations]. ( Horiuchi, Y; Takemura, T; Ueno, K, 1991) |
| " There was a trend toward fewer toxic concentrations recorded at 1 (0 percent vs 7 percent; p = 0." | 1.28 | Aminophylline in the emergency department. Maximizing safety and efficacy. ( Day, RO; Fulde, GW; Kino, R; Pearce, GA, 1991) |
| "Erythromycin is an antibiotic extensively used worldwide which is also reported to have anti-inflammatory action." | 1.28 | Erythromycin reduces the severity of bronchial hyperresponsiveness in asthma. ( Miyatake, H; Satake, T; Suzuki, R; Takagi, K; Taki, F; Taniguchi, H, 1991) |
| " This regimen is now indicated for morning and evening dosing for reversible airway obstruction, in the United States and Canada, and marks the first available treatment for these diseases to include dosing time in the therapeutic strategy." | 1.28 | Chronotherapy of reversible airways disease with once-daily evening doses of a controlled-release theophylline preparation. ( Goldenheim, PD; Schein, LK, 1991) |
| "A study of 299 patients with bronchial asthma indicates that it is of importance to include breathing with positive pressure at expiration in the complex of the rehabilitation program." | 1.28 | [The rehabilitation of bronchial asthma patients at a polyclinic]. ( Korzh, OB, 1990) |
| "Theophylline has been shown to be a potent cardiovascular teratogen in animals, but there has been no evidence linking theophylline with congenital anomalies in infants." | 1.28 | Cardiovascular anomalies associated with prenatal exposure to theophylline. ( Myers, TL; Park, JM; Schmer, V, 1990) |
| "Mean theophylline levels were higher in the standing position at all time and only the mean rate of absorption (ka) was significantly faster without any obvious change in parameters of pharmacokinetics." | 1.28 | [Posture and circadian variations in serum theophylline concentrations]. ( Hukushima, K; Iikura, Y; Kishida, M, 1990) |
| " However an optimum dosage is hardly maintained in children by the present dose of a single tablet of 280 theophylline content." | 1.28 | [Initial experiences with "Oranienburg" slow-release theophylline in asthma therapy of children and adolescents]. ( Köhler, E; Schuster, R; Sollich, V; Thal, W; Walther, H, 1990) |
| "In standard clinical practice the pharmacokinetic profile of theophylline is monitored by measuring blood levels of the drug." | 1.28 | [Different rates of theophylline clearance. A statistical study of a group of asthmatics]. ( Ardizzi, A; Bernardi, W; Bianchi, M; Bruna, S; Gai, R; Galietti, F; Giorgis, GE; Oliaro, A, 1990) |
| "Aminophylline is a potent antagonist at purinoceptor level." | 1.28 | Role of purinergic system in tracheobronchial reactivity of healthy and bronchopathic subjects. ( Carapella, N; Filippelli, A; Loffreda, A; Marmo, E; Matera, MG; Montanaro, C; Santagata, A; Servodio, R; Susanna, V, 1990) |
| "A 56-year-old male with non-atopic bronchial asthma was admitted to our hospital due to status asthmaticus." | 1.28 | [Successful treatment with continuous intravenous theophylline therapy at home for a patient with problems of oral theophylline absorption]. ( Kodaka, T; Murakawa, K; Nakashizuka, T; Nakata, K; Noguchi, M; Tsuboi, E, 1989) |
| "Gastroesophageal reflux (GER) may contribute to the persistence of asthma and may be triggered and/or exacerbated by treatment with bronchodilatory and cortisone drugs." | 1.28 | [Gastro-esophageal reflux and asthma. Clinical experience]. ( Barberio, G; Di Pasquale, F; Morabito, L; Pajno, GB; Pollicino, A; Ruggeri, C; Terranova, ML, 1989) |
| " The existing empirical evidence suggests that selecting twice-daily over once-daily dosing will incur a drop in compliance that is substantially greater than 14%." | 1.28 | Once-daily versus twice-daily dosing of theophylline. A decision analysis approach to evaluating theophylline blood levels and compliance. ( Jordan, TJ; Reichman, LB, 1989) |
| "Theophylline was measured with a Kodak Ektachem DTSC using its property of uncompetitive inhibition of alkaline phosphatase." | 1.28 | Theophylline assay on Kodak Ektachem DTSC--performance and interference by structurally-related compounds and salicylate. ( Ayers, GJ; Baldwin, AJ; Burnett, D; Fowler, AM; Goudie, JH, 1989) |
| " The average of relative bioavailability (3 cases) is 82%, 83%, 102%." | 1.28 | Sustained-release theophylline-uniphyllin in nocturnal asthmatics. ( Chiang, CD; Huang, WL; Jih, KS; Lin, TM; Mu, JY; Shih, WL; Yang, GY; Yiin, KT, 1989) |
| "On the case of a 13-year-old boy the authors demonstrate the possible non-linear relationship between long-term administration of theophylline and its serum concentrations which implies the danger of induction of limital to toxic concentrations of the drug in the blood stream when the doses are increased as required." | 1.28 | [Nonlinear theophylline kinetics in a boy on long-term theophylline therapy for bronchial asthma. Case report]. ( Dolezalová, K; Kopecká, J; Martínková, J, 1989) |
| " The AUC during the dosing interval was significantly reduced in phases B and C compared with phase A, and bioavailability relative to the fasting state was reduced to 77% +/- 15% (range 61% to 104%) in phase B and 70% +/- 16% (range 40% to 103%) in phase C." | 1.28 | Effects of time of dose in relation to food on the bioavailability of Theo-Dur Sprinkle at steady state in asthmatic children. ( Birkett, DJ; Green, B; Hughes, HM; Kneebone, GM; Lines, DR, 1989) |
| " In a period of eighteen months 1913 such assays were performed, and their influence on management was assessed by retrospective analysis in two groups--113 outpatients on stable dosage with no recent exacerbations of disease; and 28 inpatients and outpatients with concentrations exceeding 25 mg/l." | 1.27 | Theophylline prescribing, serum concentrations, and toxicity. ( Geddes, DM; Johnson, MA; Woodcock, AA, 1983) |
| " Using a nomogram derived from the plasma concentration 6 hours after dosing and the logarithm of the calculated dose, which were significantly correlated, there was a significant relation between the dose predicted and the actual dose required to produce a concentration of 55 mumol/l." | 1.27 | Theophylline dose prediction. ( Beswick, DT; Cullen, RE; Rylance, GW, 1984) |
| "This study indicates that a sustained-release tablet may be used in certain young children on an every-12-hr dosing schedule with acceptable serum theophylline fluctuation." | 1.27 | Serum theophylline levels in young children receiving a sustained-release theophylline tablet. ( Baldwin, JN; Howard, ML; Jensen, BK; Kobayashi, RH, 1984) |
| " Only 1 of the 21 patients met the criteria for dose dependency of a greater than or equal to 50% reduction in clearance with dosage increase." | 1.27 | Dose-dependent kinetics of theophylline in adults with pulmonary diseases. ( Gotz, VP; Massey, KL; Russell, WL, 1984) |
| "The ability of a dosing regimen of intravenous theophylline to achieve therapeutic serum theophylline concentrations was evaluated." | 1.27 | Inadequacy of FDA dosing guidelines for intravenous theophylline. ( Hemmes, RJ; Lopez, LM; Russell, WL; Ryerson, EG, 1984) |
| "Some patients with bronchial asthma report increased symptoms in association with weather fronts." | 1.27 | Relation between positive small air ions, weather fronts and pulmonary function in patients with bronchial asthma. ( Danziger, RE; Nelson, HS; Wagner, CJ, 1983) |
| " Patients clearly preferred preparations which permitted a simple daily dosing schedule requiring the minimum number of tablets." | 1.27 | Sustained-release theophylline preparations. A comparative survey of 467 patients. ( Palmen, FM; Steenhoek, A, 1984) |
| "Because theophylline (T) has a narrow therapeutic index, serum concentrations resulting from previous outpatient therapy must be considered when planning intravenous (IV) aminophylline dosage in the emergency department (ED)." | 1.27 | Prediction of serum theophylline levels. ( Elenbaas, RM; Payne, VW, 1984) |
| "A dosage prediction method to estimate theophylline clearance and dose requirement was evaluated in 22 outpatients with partly reversible obstructive airways disease." | 1.27 | Individualizing theophylline dosage: evaluation of a single-point maintenance dose prediction method. ( Neuenkirchen, H; Oellerich, M; Sybrecht, GW; Wilkens, JH, 1984) |
| " The solutions allowed an accurate dosage calculation, did not initiate the urge to defecate, and were retained well." | 1.27 | Treatment of acute asthma in children with rectal administration of aminophylline solution. ( Nissen, P; Pedersen, S; Sommer, B, 1984) |
| " It seems advisable to use a higher dosage of the theophyllines and perhaps it is even better to combine them with other bronchodilators." | 1.27 | Pharmacokinetics and pharmacodynamics of a short- and long-acting theophylline medication (Theolair and Theolair retard) in normals and asthmatics. Part II: Lung function and side effects. ( Fokkens, J; Kreukniet, J; Serra, R; Utama, I, 1983) |
| " Bedtime dosing may prevent nocturnal shortness of breath." | 1.27 | Pharmacologic approaches to obstructive airway disease. ( Beck, BW, 1985) |
| " Patients were then switched within one dosing interval to an equivalent single daily dose of Theo-24 and maintained on this therapy for the duration of the study." | 1.27 | Assessing the efficacy and safety of q. d. theophylline therapy: a multicenter study. ( Dockhorn, RJ; Green, AW; Green, E, 1985) |
| "Theophylline has protective action on histamine bronchospasm which is dependent on the blood levels of theophylline attained." | 1.27 | Modulation of non-specific bronchial reactivity. ( Crimi, N; Mistretta, A; Palermo, F, 1986) |
| " dosing due to unacceptable fluctuations." | 1.27 | Comparison of a new sustained-release theophylline preparation, TheoBeads, with Theo-Dur tablets in children with asthma. ( Gawchik, S; Kemp, JP; Meltzer, EO; Orgel, HA; Rooklin, AR; Tinkelman, DG; Welch, MJ, 1988) |
| " Therefore, we studied the bioavailability of a commonly prescribed slow-release theophylline formulation (Slo-Bid Gyrocaps), administered twice daily by sprinkling the beads on applesauce." | 1.27 | Bioavailability of a slow-release theophylline capsule given twice daily to preschool children with chronic asthma: comparison with liquid theophylline. ( Hendeles, L; Hill, M; McKenzie, M; Sallent, J; Stecenko, A, 1988) |
| " A therapeutic drug monitoring programme which enables individualisation of dosage on the basis of pharmacokinetic principles is described." | 1.27 | Clinical experience with theophylline. A case for monitoring serum concentrations. ( Miller, R; Pillai, G, 1988) |
| "Theophylline was administered to a group of 17 volunteers and resulted in large reductions in plasma pyridoxal-5'-phosphate levels, while plasma pyridoxal levels and urinary 4-pyridoxic acid excretion were unaffected by theophylline therapy." | 1.27 | Vitamin B6 nutritional status in asthma: the effect of theophylline therapy on plasma pyridoxal-5'-phosphate and pyridoxal levels. ( Becker, PJ; Delport, R; Serfontein, WJ; Ubbink, JB; Walters, L, 1988) |
| "Increasing awareness of the exaggerated circadian rhythm in bronchomotor tone that causes most asthmatic patients to have increased respiratory symptoms in the early morning has resulted in a search for dosing strategies that will provide maximal bronchodilatory activity at the time of reduced bronchial patency." | 1.27 | Review of the North American experience with evening administration of Uniphyl tablets, a once-daily theophylline preparation, in the treatment of nocturnal asthma. ( Arkinstall, WW, 1988) |
| " The dosage of theophylline was adjusted according to the complaints of the patients." | 1.27 | Once daily Theo-Dur in morning dippers. ( Greve, LH; Quaedvlieg, M; van der Vet, AP, 1988) |
| "Theophylline is a very efficacious medication for the treatment of bronchospastic disorders: however, it has a narrow therapeutic range of 10 to 20 micrograms/mL." | 1.27 | Problems with generic theophylline and indiscriminate brand switching. ( Klein, GL, 1987) |
| " However, bioavailability was complete both after single doses and during steady state." | 1.27 | Absorption characteristics of once-a-day slow-release theophylline preparation in children with asthma. ( Pedersen, S; Steffensen, G, 1987) |
| " The ratio, (FEV1:FVC) X 100, was calculated for each patient before and after steady-state serum level determination and dosage adjustment." | 1.27 | Using a hand-held spirometer as a monitoring tool in chronic theophylline therapy. ( Catania, PN; Mikhail, MN, 1987) |
| "In two studies, 25 diurnally active patients (6-17 years of age) were evaluated for day-night differences in serum theophylline concentration (STC) by frequent blood sampling over two consecutive 12-hr dosing intervals while being treated with Theo-Dur." | 1.27 | Clinical relevance of theophylline chronokinetics for asthmatic children. ( McGovern, JP; Scott, PH; Smolensky, MH, 1987) |
| " Mean values +/- SD (n = 16) of the steady-state characteristics were Cmin 6." | 1.27 | Steady state pharmacokinetics, metabolism and pharmacodynamics of theophylline in children after unequal twice-daily dosing of a new sustained-release formulation. ( Berdel, D; Heimann, G; Johnson, E; Kusenbach, G; Reinhardt, D; Staudinger, H; Steinijans, VW; von Berg, A, 1987) |
| "Theophylline concentration was measured in 137 simultaneously obtained paired specimens of plasma and saliva from 68 patients 2 1/2 months to 14 years of age treated with theophylline for asthma (dosage 20." | 1.27 | Monitoring theophylline therapy using citric acid-stimulated saliva in infants and children with asthma. ( Aviram, M; Ben-Zvi, Z; Gorodischer, R; Tal, A, 1987) |
| " In general, adult subjects dosed with solid theophylline formulations have morning trough theophylline concentrations 10-16% greater than corresponding evening troughs; this morning-to-evening drop is statistically significant." | 1.27 | Circadian variation in steady-state trough theophylline concentrations. ( Reed, RC; Schwartz, HJ, 1986) |
| " In contrast, on oral dosing a smaller area under the serum concentration-time curve was found during the night time (22." | 1.27 | Circadian changes in the absorption and elimination of theophylline in patients with bronchial obstruction. ( Follath, F; Uematsu, T; Vozeh, S, 1986) |
| "To evaluate the bioavailability of a new theophylline preparation suitable for once-a-day (od) oral administration, we performed a nonrandomized crossover study in which the absorption of the OD and a standard twice-a-day (bid) preparation were compared." | 1.27 | Bioavailability of a once daily-administered theophylline preparation. A comparison study. ( Abdel Rahman, MS; Bartholf, R; Lavietes, MH; Mangura, BT; Maniatis, T, 1986) |
| "The slow disappearance of the arrhythmia is a result of the prolonged half-life of theophylline in the fetus." | 1.27 | [Fetal bigeminus following combined bronchodilator treatment of the mother]. ( Neeb, U, 1986) |
| "" Extensive pharmacokinetic evaluation in patients with food intake not controlled has yielded bioavailability comparable to that of twice-daily theophylline." | 1.27 | The Contin delivery system: dosing considerations. ( Leslie, S, 1986) |
| " In the intravenous administration of theophylline (5 mg/kg) to dogs, the theophylline half-life was 4." | 1.27 | Pharmacokinetics of theophylline in beagle dogs and asthmatic patients after multiple oral doses of sustained-release theophylline tablet formulation. ( Hasegawa, T; Mizukami, Y; Nosaka, H; Ogura, Y; Satake, T; Takagi, K, 1986) |
| "1 hours and mean apparent elimination half-life was 6." | 1.27 | The pharmacokinetics of uniphyllin in nocturnal asthma. ( Alton, E; Ayesh, R; Cochrane, GM; Essex, EG; Hetzel, MR; Johnston, ID, 1986) |
| " The results demonstrated no relationship between dosing interval and the appearance of peak or trough levels with Theo-Dur." | 1.27 | Optimal time for obtaining peak and trough theophylline levels in 12-hour and 24-hour products in children. ( Cole, WQ; Lutz, CN; Miller, E; Tinkelman, DG, 1987) |
| "Treatment of theophylline overdosage with hemodialysis and/or hemoperfusion is accepted as necessary in the most severe cases." | 1.27 | Hemoperfusion/hemodialysis in the treatment of acute theophylline poisoning--description of a fatal case. ( Rongved, G; Westlie, L, 1986) |
| "56, that were well tolerated, being the theophylline blood levels, five hours after dosing 14." | 1.27 | [Sustained-release theophylline: study in a child population]. ( Díaz Fernández, M; Gracía Hidalgo, A; López Elorze, F; Mateo Cañas, G, 1986) |
| " On a 12 hourly dosing schedule, mean dose was 25." | 1.27 | Pharmacokinetics of a sustained-release theophylline preparation in infants and preschool children with asthma. ( Isles, AF; Newth, CJ, 1985) |
| " For each patient, total theophylline dosage was calculated and a theophylline blood level was obtained at the time of EEG recording." | 1.27 | Central nervous system effects of antiasthma medication--an EEG study. ( Cummins, KR; Euwer, RL; Friedman, A; Shucard, DW; Shucard, JL; Spector, SL, 1985) |
| " Significant alterations in theophylline dosage may be required during the acute and recovery phases of viral hepatitis." | 1.27 | The effects of acute viral hepatitis on theophylline clearance. ( Feinstein, RA; Miles, MV, 1985) |
| "We have carried out a steady state pharmacokinetic comparison of three different theophylline preparations in nine healthy volunteers using a once a day dosage schedule of 600 mg theophylline given before bedtime for four days." | 1.27 | Night-time pharmacokinetics of once a day theophylline: a steady state comparison of three preparations. ( Karttunen, P; Nykänen, S; Saano, V; Tukiainen, H, 1985) |
| " In patients receiving theophylline, blood levels should be monitored closely and dosage adjusted if rifampicin therapy is introduced or withdrawn." | 1.27 | Effect of rifampicin administration on theophylline pharmacokinetics in humans. ( Gray, BJ; Jamieson, AP; Moxham, J; Powell-Jackson, PR; Williams, R, 1985) |
| "Although arrhythmias associated with myocardial infarction are managed primarily with drug therapy, those associated with acute respiratory failure respond best to adequate oxygenation and correction of metabolic and hemodynamic abnormalities." | 1.27 | Managing asthma and COPD in patients with cardiovascular disease. ( George, RB; Payne, DK, 1985) |
| " The pharmacokinetic parameters (T 1/2, Kel, VD, Cl and AUC) did not differ between both groups." | 1.27 | [Pharmacokinetics of a new slow-release theophylline preparation in asthmatic children]. ( Caballero, L; Gil, MC; Mazón, A; Nieto, A, 1985) |
| "Treatment of theophylline intoxication involves attention to fluid and electrolyte balance and initiation of measures to remove theophylline from the body (gastric lavage or emesis, repeated charcoal administration by mouth, and charcoal hemoperfusion in serious cases)." | 1.27 | Theophylline toxicity. ( Ellis, EF, 1985) |
| " By generally applied measurements, including mean serum theophylline concentration, bioavailability over a single daytime dosing interval, and percent change in serum theophylline concentration over a single dosing interval, the preparations did not differ." | 1.27 | Theophylline absorption in young asthmatic children receiving sustained-release formulations. ( Haltom, JR; Szefler, SJ, 1985) |
| "Theophylline is a medium-potency bronchodilator that is useful in the treatment of reversible airway obstruction from any cause." | 1.27 | Methylxanthine therapy and reversible airway obstruction. ( McFadden, ER, 1985) |
| " This study suggests that this new sustained-release theophylline will be useful for the purpose of maintaining serum theophylline levels within the safe and therapeutic range with a twice daily dosing schedule." | 1.26 | Pharmacokinetics of Nuelin-SR 250 mg in asthmatic children: a new sustained-release theophylline. ( Liang, AY; Mitchell, EA, 1980) |
| " Six hours later the serum level was measured and the appropriate dosage of sustained-release theophylline to achieve a serum level of 10 micrograms/ml was selected from the clearance nomogram." | 1.26 | Individualization of theophylline dosage using a single serum sample following a test dose. ( Bierman, CW; Fuquay, D; Furukawa, CT; Gibaldi, M; Koup, JR; Pierson, WE; Shapiro, GG, 1982) |
| "A study was designed to evaluate the validity of the dosage guidelines for theophylline recommended by Hendeles and Weinberger." | 1.26 | Investigation of a dosage regimen for intravenous theophylline. ( Harman, EM; Hughey, MC; Robinson, JD; Yost, RL, 1982) |
| "The oral dosage of theophylline was adjusted in order to maintain a serum level between 10 and 20 micrograms/ml." | 1.26 | [Determination of the mean dose of oral theophylline in asthmatic children (author's transl)]. ( Cabanas, R; Castro-Gago, M; Cortizo, E; Couselo, JM; Fuster, M; Peña, J; Tojo, R, 1982) |
| "The great variability in the metabolism and degradation of theophylline in different people demands an individual dosage to be effective; this is to maintain the theophylline levels between the threshold of therapeutic activity (10 mg/L) to the upper limit of tolerance (15 to 20 mg/L according to different studies)." | 1.26 | [The theophylline test. Indications for the effective daily dosage (author's transl)]. ( Blaive, B; Bugnas, B; Lapalus, P; Lemoigne, F, 1982) |
| " Serum theophylline concentrations were determined and theophylline dosage (milligrams per kilogram body weight per day) was calculated in participants who had allegedly followed their medication regimen." | 1.26 | Theophylline compliance in adolescent patients with chronic asthma. ( Miller, KA, 1982) |
| " Simulations based on obtained pharmacokinetic data showed that in the average child below nine years of age oral theophylline, 6-8 mg/kg three times daily, would give plasma levels between 10 and 20 micrograms/ml (55-110 mumol/l) for about 60-70% of the day." | 1.26 | Pharmacokinetics and dose regimen of oral theophylline in children. ( Bolme, P; Eriksson, M; Lönnerholm, G; Paalzow, L, 1982) |
| "The authors propose a practical method for determining chronic oral theophylline dosage in children from slow intravenous theophylline infusion (45 minutes)." | 1.26 | [Adaptation of the oral dosage of theophylline to the asthmatic child. Value of a kinetic test by the intravenous route]. ( Albertini, M; Boutte, P; Lapalus, P; Mariani, R; Maurin, S, 1982) |
| " Food significantly reduced the absorption rate of theophylline whereas the extent of absorption of theophylline was unaffected by food." | 1.26 | Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation. ( Moeller-Petersen, J; Pedersen, S, 1982) |
| "Theophylline has a narrow therapeutic index which complicates rapid effective administration." | 1.26 | Rectal administration of theophylline in aqueous solution. ( Pedersen, S; Sommer, B, 1981) |
| " Available single-dose absorption data then were used to compare predicted fluctuations in serum concentration among nine formulations (18 brand names) for eight- and 12-hour dosing in an average child and adult (elimination half-lives of 3." | 1.26 | Relationship of formulation and dosing interval to fluctuation of serum theophylline concentration in children with chronic asthma. ( Hendeles, L; Weinberger, M; Wong, L, 1981) |
| "94 mg/kg) of anhydrous theophylline in 20 children aged 4 to 16 years, the pharmacokinetic characteristics (mean and standard deviation) were as follow: half life (T 1/2 6." | 1.26 | [Theophylline in childhood asthma. Pharmacokinetic and clinical study (author's transl)]. ( Barbier, Y; Bellon, G; Gilly, R; Plasse, JC; Satta, S, 1981) |
| " Neither an acute loading dose nor chronic administration of either drug singly produced significant changes in wheal size in response to histamine, ragweed, or grass allergens." | 1.26 | Effect of theophylline and terbutaline on immediate skin tests. ( Chipps, BE; Lichtenstein, LM; Norman, PS; Sanders, JP; Sobotka, AK; Teets, KC, 1980) |
| " It reflects whether daily oral theophylline dosage in childhood asthma is below or within the therapeutic range." | 1.26 | Salivary theophylline estimation in the management of asthma in children. ( Hutchins, P; Lena, SM; Turner, P; Wood, CB, 1980) |
| " The dosage of beta 2-mimetics and especially glucocorticoids could be reduced." | 1.26 | [Long-term therapy with a peroral effective theophyllin compound (author's transl)]. ( Pertusini, B; Zwick, H, 1980) |
| " Oxtriphylline syrup demonstrated no appreciable change in the pharmacokinetic parameter of half-life in this young age group." | 1.26 | Pharmacokinetics and taste acceptance of an alcohol-free oxtriphylline solution. ( Ellenberg, D; Ha, L; Jarboe, CH; Kadlec, GJ; Karibo, JM; Katsampes, C; Pollard, S; Simon, T; Sublett, J, 1980) |
| "In order to assess the clinical impact of dose-dependent kinetics for theophylline, the relationship between serum concentration and daily dosage among patients under the care of the University of Iowa Pediatric Allergy and Pulmonary Service was examined." | 1.26 | Dose-dependent kinetics for theophylline: observations among ambulatory asthmatic children. ( Hendeles, L; Muir, K; Riegelman, S; Sarrazin, E; Weinberger, M, 1980) |
| " Chronic therapy may also require corticosteroids, in which case toxic effects of long-term therapy can be minimized by use of alternate-day dosage of prednisone or daily inhalation of beclomethasone dipropionate." | 1.26 | Management of asthma. 2. Antiasthmatic drugs. ( Hendeles, L; Weinberger, M, 1977) |
| "The first step in management of bronchial asthma is to exclude other diseases which may present as wheezing dyspena." | 1.26 | Bronchial asthma: some aspects of pathogenesis and therapy. ( Ahmad, M; Lindquist, C, 1977) |
| " Adequate theophylline dosage is an effective bronchodilator." | 1.26 | Treatment of asthma in children. ( Hobday, JD, 1978) |
| "Gastroesophageal reflux, diagnosed by positive acid reflux test, occurred in nine patients." | 1.26 | Gastroesophageal reflux in steroid-dependent asthmatic youths. ( Christie, DL; Shapiro, GG, 1979) |
| " Using the mean values of the calculated pharmacokinetic parameters, rectal enemas providing a dose of theophylline of 6-8 mg/kg t." | 1.26 | Pharmacokinetics of theophylline in young children with asthma: comparison of rectal enema and suppositories. ( Bolme, P; Edlund, PO; Eriksson, M; Paalzow, L; Winbladh, B, 1979) |
| "The oral dosage of aminophylline required for therapeutic "trough" serum theophylline levels was studied in 150 children, 16 months to 19 years old (mean 8." | 1.26 | Aminophylline therapy in children: guidelines for dosage. ( Newcomb, RW; Rangsithienchai, P, 1977) |
| " When initiating continuous oral aminophylline therapy, dosage guidelines, based on the mean ATC calculated for each group, were predicted, and trough theophylline serum levels of 10mug/ml were obtained." | 1.26 | Oral aminophylline therapy. Increased dosage requirements in children. ( Austrian, S; Johnson, PB; Miller, KW; Strem, EL; Zaske, DE, 1977) |
| "Theophylline levels were measured 2 hours after each dose and were satisfactory in both schedules." | 1.26 | Effect of practical timing of dosage on theophylline blood levels in asthmatic children treated with choline theophyllinate. ( Baillie, E; Godfrey, S; McKenzie, SA, 1978) |
| " Following intensive round-the-clock therapy with theophylline (the dosage of which maintained serum levels of theophylline between 10 microgram/ml and 20 microgram/ml) and therapy with prednisone (20 mg twice daily for three weeks or more), there were improvements in spirometric and body plethysmographic measurements." | 1.26 | Irreversibility of obstructive changes in severe asthma in childhood. ( Bell, TD; Buck, VM; Chai, H; Cooley, RL; Leung, PK; Loren, ML, 1978) |
| "Therapy for bronchial asthma should be preventive when possible." | 1.26 | New drugs in treatment of asthma. ( Kaiser, HB; Weisberg, SC, 1976) |
| "A practical method for monitoring serum theophylline concentrations has been used to investigate intravenous aminophylline dosage requirements." | 1.26 | Intravenous aminophylline dosage. Use of serum theophylline measurement for guidance. ( Chidsey, CA; Ginchansky, EJ; Matthay, RA; Petty, TL; Weinberger, MW, 1976) |
| " The mean half-life of dyphylline is 2." | 1.25 | The pharmacokinetics of dihydroxypropyltheophylline: a basis for rational therapy. ( Bierman, CW; Simons, FE; Simons, KJ, 1975) |
| " Using a daily dosage of up to 16 mg/kg bodyweight more than 80% of children showed definite improvement leading to prevention or significant reduction of acute attacks and clearly reduced dyspnoeic states between attacks." | 1.25 | [Long-term out-patient treatment of children with asthma with a theophylline-ephedrine-hydroxyzine combination (author's transl)]. ( Götz, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1684 (64.40) | 18.7374 |
| 1990's | 608 (23.25) | 18.2507 |
| 2000's | 238 (9.10) | 29.6817 |
| 2010's | 74 (2.83) | 24.3611 |
| 2020's | 11 (0.42) | 2.80 |
| Authors | Studies |
|---|---|
| Medwid, JB | 1 |
| Paul, R | 2 |
| Baker, JS | 1 |
| Brockman, JA | 2 |
| Du, MT | 1 |
| Hallett, WA | 2 |
| Hanifin, JW | 2 |
| Hardy, RA | 1 |
| Tarrant, ME | 2 |
| Torley, LW | 2 |
| Callahan, FM | 1 |
| Fabio, PF | 1 |
| Johnson, BD | 1 |
| Lenhard, RH | 1 |
| Zablocki, J | 1 |
| Kalla, R | 1 |
| Perry, T | 1 |
| Palle, V | 1 |
| Varkhedkar, V | 1 |
| Xiao, D | 1 |
| Piscopio, A | 1 |
| Maa, T | 1 |
| Gimbel, A | 1 |
| Hao, J | 1 |
| Chu, N | 1 |
| Leung, K | 1 |
| Zeng, D | 1 |
| Kodimuthali, A | 1 |
| Jabaris, SS | 1 |
| Pal, M | 1 |
| Han, YY | 1 |
| Forno, E | 1 |
| Celedón, JC | 1 |
| Sultan, K | 1 |
| Zamir, A | 1 |
| Ashraf, W | 1 |
| Imran, I | 2 |
| Saeed, H | 2 |
| Rehman, AU | 1 |
| Majeed, A | 2 |
| Rasool, MF | 2 |
| Wu, P | 1 |
| Xu, B | 1 |
| Shen, A | 1 |
| Zeng, H | 1 |
| Shen, K | 1 |
| Reyes-García, J | 1 |
| Díaz-Hernández, V | 1 |
| Carbajal-García, A | 1 |
| Casas-Hernández, MF | 1 |
| Sommer, B | 3 |
| Montaño, LM | 1 |
| Fukumitsu, K | 1 |
| Kanemitsu, Y | 1 |
| Kurokawa, R | 1 |
| Takeda, N | 1 |
| Tajiri, T | 1 |
| Nishiyama, H | 1 |
| Ito, K | 6 |
| Inoue, Y | 1 |
| Yamamoto, S | 1 |
| Mori, Y | 1 |
| Fukuda, S | 1 |
| Uemura, T | 1 |
| Ohkubo, H | 1 |
| Maeno, K | 1 |
| Ito, Y | 4 |
| Oguri, T | 1 |
| Takemura, M | 1 |
| Niimi, A | 1 |
| Boylan, PM | 1 |
| Abdalla, M | 1 |
| Bissell, B | 1 |
| Malesker, MA | 1 |
| Santibañez, M | 1 |
| Smith, Z | 1 |
| Calzetta, L | 2 |
| Matera, MG | 4 |
| Goldstein, MF | 3 |
| Fairweather, WR | 2 |
| Howard, WW | 2 |
| Cazzola, M | 8 |
| Rogliani, P | 1 |
| Zhao, X | 1 |
| Ma, H | 1 |
| Pan, Q | 1 |
| Wang, H | 1 |
| Qian, X | 1 |
| Song, P | 2 |
| Zou, L | 1 |
| Mao, M | 1 |
| Xia, S | 1 |
| Ge, G | 1 |
| Yang, L | 1 |
| Khalid, R | 1 |
| Alasmari, F | 1 |
| Alanazi, MM | 1 |
| Alqahtani, F | 1 |
| Balakrishnan, S | 1 |
| Rakesh, PS | 1 |
| Jayasankar, S | 1 |
| Sunilkumar, M | 1 |
| Krishnaveni, V | 1 |
| Gopal, B | 1 |
| Manu, MS | 1 |
| Achuthan Nair, S | 1 |
| Komasawa, N | 1 |
| Nishihara, I | 1 |
| Nishimura, W | 1 |
| Minami, T | 1 |
| Koh, MS | 2 |
| Yii, AC | 1 |
| Ong, YY | 1 |
| Abusnina, A | 1 |
| Lugnier, C | 1 |
| Page, C | 3 |
| Saint, GL | 1 |
| Semple, MG | 1 |
| Sinha, I | 2 |
| Hawcutt, DB | 1 |
| Mahemuti, G | 1 |
| Zhang, H | 1 |
| Li, J | 2 |
| Tieliwaerdi, N | 1 |
| Ren, L | 1 |
| Srivastava, D | 1 |
| Fatima, Z | 1 |
| Kaur, CD | 1 |
| Szefler, SJ | 17 |
| Ma, Y | 1 |
| Xue, L | 1 |
| Chen, X | 1 |
| Kang, Y | 1 |
| Wang, Y | 4 |
| Wang, L | 1 |
| Henriksen, DP | 1 |
| Davidsen, JR | 1 |
| Laursen, CB | 1 |
| Hanania, NA | 1 |
| Dini, FL | 2 |
| Caramori, G | 6 |
| Coppolino, I | 1 |
| Cannavò, MF | 1 |
| Nucera, F | 1 |
| Proietto, A | 1 |
| Mumby, S | 1 |
| Ruggeri, P | 1 |
| Adcock, IM | 5 |
| Goodwin, AT | 1 |
| Singanayagam, A | 1 |
| Jenkins, G | 1 |
| Barnes, PJ | 28 |
| Haahtela, T | 7 |
| Lehtimäki, L | 1 |
| Ahonen, E | 1 |
| Harju, T | 1 |
| Jartti, T | 1 |
| Kankaanranta, H | 1 |
| Korhonen, K | 1 |
| Mäkelä, M | 1 |
| Puurunen, M | 1 |
| Sovijärvi, A | 1 |
| Valovirta, E | 1 |
| Venho, KK | 1 |
| Chen, ZC | 1 |
| Ding, JJ | 1 |
| Qian, HY | 1 |
| Lin, XH | 1 |
| Feng, KQ | 1 |
| Wang, J | 1 |
| Al-Alawi, M | 1 |
| Hassan, T | 1 |
| Chotirmall, SH | 1 |
| Cazzoletti, L | 1 |
| Corsico, AG | 1 |
| Albicini, F | 1 |
| Di Vincenzo, EM | 1 |
| Gini, E | 1 |
| Grosso, A | 1 |
| Ronzoni, V | 1 |
| Bugiani, M | 2 |
| Pirina, P | 1 |
| Cerveri, I | 1 |
| FOURTON, A | 1 |
| Tohda, Y | 4 |
| Rajanandh, MG | 2 |
| Nageswari, AD | 2 |
| Ilango, K | 2 |
| Tsuchida, T | 1 |
| Matsuse, H | 3 |
| Okpapi, A | 2 |
| Friend, AJ | 2 |
| Turner, SW | 2 |
| Bossé, Y | 1 |
| Manoharan, A | 1 |
| Anderson, WJ | 1 |
| Lipworth, J | 1 |
| Ibrahim, I | 1 |
| Lipworth, BJ | 7 |
| Ohta, K | 5 |
| Ichinose, M | 1 |
| Nagase, H | 1 |
| Yamaguchi, M | 4 |
| Sugiura, H | 1 |
| Yamauchi, K | 3 |
| Adachi, M | 6 |
| Akiyama, K | 4 |
| Kazimierová, I | 1 |
| Jošková, M | 1 |
| Pecháňová, O | 1 |
| Šutovská, M | 1 |
| Fraňová, S | 1 |
| Bain, E | 1 |
| Pierides, KL | 1 |
| Clifton, VL | 1 |
| Hodyl, NA | 1 |
| Stark, MJ | 1 |
| Crowther, CA | 1 |
| Middleton, P | 1 |
| Abadoglu, O | 1 |
| Berk, S | 1 |
| Page, CP | 13 |
| Boonsawat, W | 2 |
| Thinkhamrop, B | 1 |
| Lal, D | 1 |
| Manocha, S | 1 |
| Ray, A | 1 |
| Vijayan, VK | 1 |
| Kumar, R | 1 |
| Calabrese, EJ | 1 |
| Dhawan, G | 1 |
| Kapoor, R | 1 |
| Celis, P | 1 |
| Rada, G | 1 |
| Oñatibia-Astibia, A | 1 |
| Martínez-Pinilla, E | 1 |
| Franco, R | 1 |
| Cooney, L | 1 |
| Hawcutt, D | 1 |
| Spina, D | 10 |
| Chen, P | 1 |
| Dai, A | 2 |
| Shang, S | 1 |
| Kong, L | 1 |
| Preskorn, SH | 1 |
| Singh, V | 1 |
| Kuebler, KK | 1 |
| Buchsel, PC | 1 |
| Balkstra, CR | 1 |
| Dalbeck, M | 1 |
| Boskabady, MH | 1 |
| Rezaeitalab, F | 1 |
| Rahimi, N | 1 |
| Dehnavi, D | 1 |
| Arand, M | 1 |
| Igarashi, T | 2 |
| Iwakawa, S | 2 |
| Spears, M | 1 |
| Donnelly, I | 1 |
| Jolly, L | 1 |
| Brannigan, M | 1 |
| McSharry, C | 1 |
| Lafferty, J | 1 |
| Chaudhuri, R | 1 |
| Braganza, G | 1 |
| Wood, S | 1 |
| Thomson, NC | 2 |
| Tekade, AR | 2 |
| Gattani, SG | 3 |
| Baba, K | 2 |
| Hattori, T | 2 |
| Yagi, T | 2 |
| Onoe, K | 1 |
| Kawai, S | 1 |
| Yoshida, K | 2 |
| Yamaguchi, E | 1 |
| Kukreti, R | 1 |
| Guleria, R | 1 |
| Schatz, M | 6 |
| Dombrowski, MP | 4 |
| Dennis, RJ | 3 |
| Solarte, I | 5 |
| Fitzgerald, JM | 3 |
| Stiefelhagen, P | 1 |
| Ukena, D | 10 |
| Farel, RM | 1 |
| Contoli, M | 1 |
| Papi, A | 1 |
| Shiohira, H | 1 |
| Fujii, M | 1 |
| Koizumi, N | 1 |
| Kondoh, M | 1 |
| Watanabe, Y | 3 |
| Cosio, BG | 1 |
| Soriano, JB | 3 |
| El-Bitar, MK | 1 |
| Boustany, RM | 1 |
| Shukla, D | 3 |
| Chakraborty, S | 3 |
| Singh, S | 2 |
| Mishra, B | 3 |
| Hozawa, S | 1 |
| Haruta, Y | 2 |
| Terada, M | 1 |
| Yamakido, M | 2 |
| Lang, DM | 2 |
| Polansky, M | 1 |
| Sherman, MS | 1 |
| Newman, RB | 2 |
| Momirova, V | 1 |
| Wise, R | 2 |
| Landon, M | 2 |
| Rouse, DJ | 1 |
| Lindheimer, M | 2 |
| Caritis, SN | 2 |
| Sheffield, J | 1 |
| Miodovnik, M | 2 |
| Wapner, RJ | 2 |
| Varner, MW | 2 |
| O'Sullivan, MJ | 2 |
| Conway, DL | 2 |
| Moon, HG | 1 |
| Kim, YS | 1 |
| Choi, JP | 1 |
| Choi, DS | 1 |
| Yoon, CM | 1 |
| Jeon, SG | 1 |
| Gho, YS | 1 |
| Kim, YK | 1 |
| Momeni, A | 1 |
| Mohammadi, MH | 1 |
| Wilson, SR | 1 |
| Strub, P | 1 |
| Buist, AS | 2 |
| Knowles, SB | 1 |
| Lavori, PW | 1 |
| Lapidus, J | 1 |
| Vollmer, WM | 2 |
| Park, HY | 1 |
| Lim, SY | 1 |
| Park, HK | 1 |
| Park, SY | 1 |
| Kim, TS | 1 |
| Suh, GY | 1 |
| FRANKLIN, HL | 1 |
| PRIGAL, SJ | 1 |
| BROOKS, AM | 1 |
| HARRIS, R | 1 |
| Worth, H | 3 |
| Gillissen, A | 1 |
| Kadam, VD | 1 |
| Kovacevic, A | 1 |
| Schwahn, B | 1 |
| Schuster, A | 1 |
| Korematsu, S | 1 |
| Yamamoto, K | 2 |
| Nagakura, T | 3 |
| Miyahara, H | 1 |
| Okazaki, N | 1 |
| Akiyoshi, K | 1 |
| Maeda, T | 1 |
| Suenobu, S | 1 |
| Izumi, T | 2 |
| Short, SM | 1 |
| Cogdill, RP | 1 |
| D'Amico, F | 1 |
| Drennen, JK | 1 |
| Anderson, CA | 1 |
| Chohnabayashi, N | 1 |
| Nasu, H | 1 |
| Nishimura, N | 1 |
| Uchiyama, N | 1 |
| Kizu, J | 3 |
| Barakat, NS | 1 |
| Al-Suwayeh, SA | 1 |
| Taha, EI | 1 |
| Bakry Yassin, AE | 1 |
| Hardy-Fairbanks, AJ | 1 |
| Baker, ER | 1 |
| Tilley, SL | 1 |
| Mizutani, N | 1 |
| Inui, S | 1 |
| Yoshino, S | 1 |
| Nabe, T | 1 |
| Patel, MM | 1 |
| Amin, AF | 1 |
| Soni, ML | 1 |
| Namdeo, KP | 1 |
| Jain, SK | 1 |
| Gupta, M | 1 |
| Dangi, JS | 1 |
| Kumar, M | 2 |
| Dangi, YS | 1 |
| Lin, K | 1 |
| Wang, C | 1 |
| Liao, X | 1 |
| Nishima, S | 2 |
| Hayallah, AM | 1 |
| Elgaher, WA | 1 |
| Salem, OI | 1 |
| Alim, AA | 2 |
| Schudt, C | 3 |
| Hatzelmann, A | 2 |
| Beume, R | 1 |
| Tenor, H | 2 |
| Rodrigo, G | 2 |
| Hartnett, BJ | 1 |
| Marlin, GE | 2 |
| Swift, I | 1 |
| Satti, A | 1 |
| Kim, V | 1 |
| Make, BJ | 1 |
| Newell, J | 1 |
| Steiner, RM | 1 |
| Wilson, C | 1 |
| Murphy, JR | 1 |
| Silverman, EK | 1 |
| Criner, GJ | 1 |
| Favreau, H | 1 |
| Bacon, SL | 1 |
| Joseph, M | 1 |
| Labrecque, M | 1 |
| Lavoie, KL | 1 |
| Miravitlles, M | 1 |
| Soler-Cataluña, JJ | 1 |
| Calle, M | 1 |
| Molina, J | 1 |
| Almagro, P | 1 |
| Quintano, JA | 1 |
| Riesco, JA | 1 |
| Trigueros, JA | 1 |
| Piñera, P | 1 |
| Simón, A | 1 |
| López-Campos, JL | 1 |
| Ancochea, J | 1 |
| Imai, K | 3 |
| Munehisa, Y | 1 |
| Yoshikuni, Y | 1 |
| Morita, T | 2 |
| Nomura, H | 1 |
| Kimura, Y | 1 |
| Mimaki, Y | 1 |
| Kihira, K | 1 |
| Hayallah, AK | 1 |
| Talhouni, AA | 1 |
| Karasu-Minareci, E | 1 |
| Kaya, Y | 1 |
| Belgin Yildirim, F | 1 |
| Nainwal, N | 1 |
| Nie, H | 1 |
| Zhang, G | 1 |
| Liu, M | 1 |
| Ding, X | 1 |
| Huang, Y | 1 |
| Hu, S | 1 |
| Yurdakul, AS | 2 |
| Calişir, HC | 1 |
| Tunçtan, B | 1 |
| Ogretensoy, M | 1 |
| Dempsey, OJ | 1 |
| Fowler, SJ | 1 |
| Wilson, A | 1 |
| Kennedy, G | 1 |
| Dahl, R | 3 |
| Larsen, BB | 1 |
| Venge, P | 2 |
| Goonetilleke, AK | 1 |
| Munasinghe, TM | 1 |
| Cooray, HC | 1 |
| Balasuriya, WK | 1 |
| Fernando, N | 1 |
| Balfour-Lynn, IM | 2 |
| Elborn, JS | 1 |
| Koh, YI | 1 |
| Choi, IS | 1 |
| Bense, L | 1 |
| Keeley, D | 4 |
| Fotinos, C | 1 |
| Dodson, S | 1 |
| Ota, K | 1 |
| Nakano, J | 1 |
| Galvão, C | 1 |
| Criado, RF | 1 |
| Criado, PR | 1 |
| Valente, NY | 1 |
| de Mello, JF | 1 |
| Fernandes, MF | 1 |
| Self, TH | 3 |
| Redmond, AM | 1 |
| Nguyen, WT | 1 |
| Hooker, AC | 1 |
| Foracchia, M | 1 |
| Dodds, MG | 1 |
| Vicini, P | 1 |
| Lai, CK | 2 |
| De Guia, TS | 1 |
| Kim, YY | 1 |
| Kuo, SH | 2 |
| Mukhopadhyay, A | 1 |
| Trung, PL | 1 |
| Zhong, NS | 2 |
| Zainudin, N | 1 |
| Zainudin, BM | 1 |
| Zhou, X | 1 |
| Wang, Z | 1 |
| Lin, Y | 1 |
| Zhu, Y | 1 |
| Lee, DK | 3 |
| Gray, RD | 1 |
| Kaditis, AG | 1 |
| Gourgoulianis, K | 1 |
| Winnie, G | 1 |
| Yanagawa, H | 1 |
| Shiraga, M | 1 |
| Nakamura, Y | 2 |
| Azuma, M | 1 |
| Yoneda, K | 1 |
| Ogawa, H | 1 |
| Kitamuro, C | 1 |
| Maeda, K | 2 |
| Miki, M | 1 |
| Matsumori, Y | 1 |
| Sugita, A | 1 |
| Hashimoto, S | 1 |
| Hara, C | 1 |
| Tani, K | 1 |
| Sone, S | 2 |
| Wang, CH | 1 |
| Lin, HC | 1 |
| Lin, CH | 1 |
| Yu, CT | 1 |
| Liu, SL | 1 |
| Huang, KH | 1 |
| Chung, KF | 12 |
| Kuo, HP | 1 |
| Radenne, F | 1 |
| Verkindre, C | 1 |
| Tonnel, AB | 1 |
| Obase, Y | 1 |
| Shimoda, T | 2 |
| Kawano, T | 1 |
| Saeki, S | 2 |
| Tomari, SY | 1 |
| Mitsuta-Izaki, K | 1 |
| Kinoshita, M | 1 |
| Kohno, S | 2 |
| Choo, JH | 1 |
| Nagata, M | 3 |
| Sutani, A | 1 |
| Kikuchi, I | 1 |
| Sakamoto, Y | 3 |
| Green, RH | 1 |
| Brightling, CE | 1 |
| Pavord, ID | 3 |
| Wardlaw, AJ | 1 |
| Somoskövi, A | 1 |
| Tamási, L | 1 |
| Bártfai, Z | 1 |
| Tolnay, E | 1 |
| Fozard, JR | 2 |
| Sakai, H | 1 |
| Soejima, Y | 1 |
| Tsurikisawa, N | 1 |
| Taniguchi, M | 1 |
| Suzuki, S | 1 |
| Dashash, NA | 1 |
| Mukhtar, SH | 1 |
| Liccardi, G | 1 |
| Canonica, GW | 1 |
| D'Amato, M | 1 |
| D'Amato, G | 1 |
| Passalacqua, G | 1 |
| Kimura, M | 2 |
| Okafuji, I | 1 |
| Yoshida, T | 2 |
| Adcock, I | 3 |
| Shah, L | 1 |
| Wilson, AJ | 3 |
| Gibson, PG | 3 |
| Coughlan, J | 2 |
| Bhatia, RS | 1 |
| PIERSANTI, F | 1 |
| GALUP, J | 1 |
| MARTINI, H | 1 |
| HILLER, E | 2 |
| ECKENBERG, E | 1 |
| PREUNER, R | 1 |
| VON PRITTWITZ, J | 1 |
| GAFFRON, J | 1 |
| BREHMER, W | 1 |
| RAMSER, O | 1 |
| HEDENIUS, P | 2 |
| SALOMON, A | 1 |
| HERSCHFUS, JA | 1 |
| RADOVSKY, SS | 1 |
| SEGAL, MS | 2 |
| DANN, S | 1 |
| DE GRAFF, AC | 1 |
| BROWN, FR | 1 |
| KUPPERMAN, HS | 1 |
| WOLFER-BIANCHI, R | 1 |
| RATHERT, H | 1 |
| BURGER, W | 1 |
| HOCHLI, M | 1 |
| SNIDER, GL | 2 |
| BARNETT, K | 1 |
| RADNER, DB | 1 |
| MOSKO, MM | 1 |
| HAHN, L | 1 |
| EISELE, A | 1 |
| KOWALSKI, F | 1 |
| WAXLER, SH | 1 |
| ONESTI, SJ | 1 |
| NOLKE, AC | 1 |
| SAUDAN, Y | 2 |
| ASCIONE, A | 2 |
| VITALE, P | 2 |
| MAYERL, H | 2 |
| BUHR, G | 2 |
| KESSLER, F | 2 |
| SUDECK, G | 1 |
| SCHLUGER, J | 1 |
| MCGINN, JT | 1 |
| BURBANK, B | 1 |
| PHEAR, DN | 1 |
| GOLSONG, HJ | 1 |
| JUNGST, W | 2 |
| BRANDESKY, G | 1 |
| HAMMERL, H | 2 |
| PICHLER, O | 3 |
| KALLOS, P | 1 |
| KALLOS-DEFFNER, L | 1 |
| WILDE, W | 1 |
| CASTELFRANCO, M | 1 |
| GHIRINGHELLI, G | 1 |
| PIANE, C | 1 |
| CASS, LJ | 1 |
| FREDERIK, WS | 1 |
| FRANKE, W | 1 |
| ELIACHAR, E | 1 |
| TASSY, R | 1 |
| CANY, J | 1 |
| FRANK, DE | 1 |
| TUREK, LH | 1 |
| FOND, IA | 1 |
| PERLMAN, E | 1 |
| SAPOZNIK, HI | 1 |
| KOCHSIEK, K | 1 |
| NELLE, K | 1 |
| BERGAMI, G | 1 |
| ZACCARDI, GF | 1 |
| CENACCHI, GC | 1 |
| DI PAOLO, E | 1 |
| STRANG, LB | 1 |
| KNOX, EG | 1 |
| BLANC, P | 1 |
| CAMOES, S | 2 |
| DELAUDE, A | 1 |
| JORDA, MF | 1 |
| CAZAVET, A | 1 |
| DUBOW, E | 1 |
| EISEN, AH | 1 |
| BACAL, HL | 1 |
| GIZAN, CJ | 1 |
| GRZAN, CJ | 1 |
| KUSUNOKI, G | 1 |
| GANDEVIA, B | 1 |
| GUERTLER, J | 1 |
| FRIEDMAN, HT | 1 |
| GOECHT, R | 1 |
| THOMAS, JW | 1 |
| SJOGREN, I | 1 |
| SCHILLER, IW | 3 |
| MICHELSON, AL | 1 |
| FRIEDMAN, S | 1 |
| KARLIN, H | 1 |
| LEVY, DL | 1 |
| CORDOVA, A | 1 |
| COSIN, M | 1 |
| BIEDERMAN, JB | 1 |
| DAMRAU, F | 2 |
| GUENTHNER, W | 1 |
| ROMANSKI, B | 1 |
| UNGER, DL | 3 |
| BLOOM, S | 1 |
| MARKOW, H | 1 |
| TOWNLEY, RG | 5 |
| BRONSTEIN, SB | 1 |
| LEVIN, SJ | 2 |
| SCHERER, RA | 1 |
| JONES, RS | 1 |
| WHARTON, MJ | 1 |
| BUSTON, MH | 1 |
| TOURAINE, R | 1 |
| BIRON, A | 1 |
| JACKSON, RH | 4 |
| MCHENRY, JI | 1 |
| MORELAND, FB | 1 |
| RAYMER, WJ | 2 |
| ETTER, RL | 2 |
| GHORY, JE | 1 |
| BERNSTEIN, IL | 4 |
| KREINDLER, L | 1 |
| AUSDENMOORE, RW | 1 |
| HEISEN, AJ | 1 |
| HEISEN, A | 1 |
| HEULIN, A | 1 |
| SORS, C | 1 |
| KLOTZ, SD | 1 |
| ZIFFER, AM | 1 |
| TRESSER, M | 1 |
| BECK, GJ | 1 |
| TAUB, SJ | 2 |
| SPIERS, AS | 1 |
| BOPP, KP | 1 |
| WOLFROMM, R | 2 |
| NATAF, P | 1 |
| UMEDA, H | 1 |
| WOOLF, CR | 1 |
| SHERMAN, WB | 1 |
| GONKKIEWICZ, M | 1 |
| BARZO, P | 1 |
| BAKONYI, Z | 1 |
| LANYI, M | 1 |
| POLOTSKAIA, EL | 1 |
| LEVINA, SI | 1 |
| UNTERHARNSHEIDT, F | 1 |
| RICHTER, W | 1 |
| RUBINSTEIN, K | 1 |
| ELMING, N | 1 |
| TURIAF, J | 2 |
| MARLAND, P | 1 |
| MILLASANTOS, J | 1 |
| DARNELLTEY, A | 1 |
| AARONSON, AL | 1 |
| EHRLICH, NJ | 1 |
| FRANKEL, DB | 1 |
| GOLDTHORPE, AM | 1 |
| MILTON, RJ | 1 |
| MOFFAT, RJ | 1 |
| PEATFIELD, BJ | 1 |
| RYDE, DH | 1 |
| GROVER, FW | 1 |
| BARRAS, G | 1 |
| HOFMANN, E | 1 |
| HEINRICH, K | 1 |
| WEISSBECKER, L | 1 |
| JACOBI, H | 1 |
| PFLEGER, K | 1 |
| MACLAREN, WR | 1 |
| NICOLETTI, G | 1 |
| GIUSTI, C | 1 |
| SORBINI, A | 1 |
| PENGELLY, CD | 1 |
| BROCKBANK, W | 1 |
| KATZ AVRUTZKI, F | 1 |
| KOHN, CM | 1 |
| LANOFF, G | 1 |
| LEHNERT, G | 1 |
| SZADKOWSKI, D | 1 |
| WEISNAGEL, J | 1 |
| LIPMAN, WH | 1 |
| MILLER, J | 2 |
| PERRICONI, HM | 1 |
| RAIMONDO, NH | 1 |
| PESET REIG, R | 1 |
| LLOPIS LLOMBART, R | 1 |
| LOPEZ MERINO, V | 1 |
| PULS, RJ | 1 |
| GRATER, WC | 1 |
| Coghlan, D | 1 |
| Powell, C | 1 |
| Eber, E | 2 |
| Frischer, T | 1 |
| Götz, M | 3 |
| Horak, E | 1 |
| Kurz, H | 1 |
| Riedler, J | 1 |
| Schmitzberger, R | 1 |
| Zach, M | 4 |
| Bracken, MB | 1 |
| Triche, EW | 1 |
| Belanger, K | 1 |
| Saftlas, A | 1 |
| Beckett, WS | 1 |
| Leaderer, BP | 1 |
| Lenhardt, R | 1 |
| Malone, A | 1 |
| Grant, EN | 1 |
| Weiss, KB | 1 |
| Suessmuth, S | 1 |
| Freihorst, J | 1 |
| Gappa, M | 1 |
| Taci, N | 1 |
| Eren, A | 1 |
| Sipit, T | 1 |
| Terpigorev, SA | 1 |
| Il'chenko, VA | 1 |
| Kol'tsun, SS | 1 |
| Goriainov, AD | 1 |
| Stotskaia, TV | 1 |
| Averina, TK | 1 |
| Paleev, NR | 2 |
| PIOT, C | 1 |
| URBANO, L | 1 |
| Hansel, TT | 2 |
| Tennant, RC | 1 |
| Tan, AJ | 1 |
| Higgins, LA | 1 |
| Neighbour, H | 1 |
| Erin, EM | 1 |
| Thom, EA | 1 |
| Mabie, W | 1 |
| McNellis, D | 1 |
| Hauth, JC | 1 |
| Leveno, KJ | 1 |
| Meis, P | 1 |
| Fukkuda, T | 1 |
| Zhang, JX | 1 |
| Lin, HQ | 1 |
| Chen, JS | 1 |
| Xu, YJ | 1 |
| Donohue, JF | 1 |
| Lim, KG | 1 |
| Hirose, M | 2 |
| Yokoyama, H | 1 |
| Iinuma, K | 1 |
| McKean, M | 3 |
| Insanov, AB | 1 |
| Mustafaeva, LI | 1 |
| GARDNER, RA | 1 |
| HANSEN, AE | 1 |
| EWING, PL | 1 |
| EMERSON, GA | 1 |
| RUDOLPH, JA | 2 |
| FRIEDLAND, B | 1 |
| GRATER, W | 1 |
| Pelaia, G | 2 |
| Vatrella, A | 2 |
| Gallelli, L | 1 |
| Maselli, R | 2 |
| Marsico, SA | 1 |
| Bates, CE | 1 |
| Currie, GP | 3 |
| Cowan, LM | 1 |
| McFarlane, LC | 2 |
| Fukuchi, Y | 1 |
| Grouse, L | 1 |
| Mizutani, R | 1 |
| Rabe, KF | 3 |
| Rennard, SI | 2 |
| Bocheńska-Marciniak, M | 1 |
| Górski, P | 1 |
| Kuna, P | 1 |
| Płusa, T | 3 |
| Basyigit, I | 1 |
| Yildiz, F | 1 |
| Kacar Ozkara, S | 1 |
| Boyaci, H | 1 |
| Ilgazli, A | 1 |
| Ozkarakas, O | 1 |
| Ponticiello, A | 1 |
| Parrella, R | 1 |
| Dennis, R | 2 |
| Nishihara, K | 2 |
| Kanazawa, M | 1 |
| Terashi, Y | 1 |
| Nagao, K | 1 |
| Takizawa, T | 1 |
| Sayers, I | 1 |
| Hall, IP | 1 |
| Gluck, JC | 1 |
| Gluck, PA | 1 |
| Beeh, KM | 1 |
| Beier, J | 1 |
| Lerch, C | 1 |
| Schulz, AK | 1 |
| Buhl, R | 1 |
| Wang, CZ | 1 |
| Lin, KX | 1 |
| Qian, GS | 1 |
| Zhuo, WL | 1 |
| Li, SP | 1 |
| Zhao, ZQ | 1 |
| Liao, XQ | 1 |
| Song, YX | 1 |
| Osur, SL | 1 |
| Wilson, AM | 1 |
| Shirai, T | 1 |
| Matsui, T | 1 |
| Suzuki, K | 1 |
| Chida, K | 1 |
| Irani, AM | 1 |
| Isakov, VA | 1 |
| Chereĭskaia, NK | 1 |
| Ivanova, OV | 1 |
| Kobayashi, H | 3 |
| Tanifuji, Y | 2 |
| Pian, HD | 1 |
| Inoue, H | 4 |
| Abou-Basha, LI | 1 |
| Wahman, LF | 1 |
| Hamza, A | 1 |
| Aboul-Enein, HY | 1 |
| Salmeron, S | 2 |
| Mangiapane, S | 1 |
| Schulz, M | 2 |
| Mühlig, S | 1 |
| Ihle, P | 1 |
| Schubert, I | 1 |
| Waldmann, HC | 1 |
| Sonia, M | 1 |
| Ikram, D | 1 |
| Radhouane, F | 1 |
| Ali, BK | 1 |
| Noga, O | 1 |
| Hanf, G | 1 |
| Görges, D | 1 |
| Dinh, QT | 1 |
| Groneberg, DA | 1 |
| Suttorp, N | 1 |
| Kunkel, G | 8 |
| Tomita, K | 4 |
| Hanaki, K | 1 |
| Hasegawa, Y | 1 |
| Watanabe, M | 1 |
| Sano, H | 1 |
| Igishi, T | 2 |
| Burioka, N | 4 |
| Hitsuda, Y | 1 |
| Horimukai, K | 1 |
| Fukutani, K | 2 |
| Sugimoto, Y | 1 |
| Yamamoto, M | 1 |
| Kato, K | 1 |
| Ikeda, T | 1 |
| Konishi, T | 2 |
| Tokuyasu, H | 1 |
| Kawasaki, Y | 1 |
| Yajima, H | 1 |
| Sejima, H | 1 |
| Isobe, T | 1 |
| Takabatake, T | 1 |
| Shimizu, E | 3 |
| Murali, PM | 1 |
| Rajasekaran, S | 1 |
| Krishnarajasekar, OR | 1 |
| Perumal, T | 1 |
| Nalini, K | 1 |
| Lakshmisubramanian, S | 1 |
| Deivanayagam, CN | 1 |
| Iwasaki, S | 1 |
| Yamakage, M | 1 |
| Satoh, J | 1 |
| Namiki, A | 1 |
| Takata, K | 1 |
| Saruwatari, J | 1 |
| Nakada, N | 1 |
| Nakagawa, M | 1 |
| Fukuda, K | 2 |
| Tanaka, F | 1 |
| Takenaka, S | 1 |
| Mihara, S | 1 |
| Marubayashi, T | 1 |
| Nakagawa, K | 1 |
| Shah, AR | 1 |
| Sharples, LD | 1 |
| Solanki, RN | 1 |
| Shah, KV | 1 |
| Zhou, B | 1 |
| Cai, SX | 1 |
| Zou, F | 1 |
| Cai, CQ | 1 |
| Zhao, HJ | 1 |
| Seddon, P | 1 |
| Bara, A | 1 |
| Ducharme, FM | 2 |
| Lasserson, TJ | 2 |
| Chambers, C | 1 |
| Itazawa, T | 1 |
| Adachi, Y | 1 |
| Nakabayashi, M | 1 |
| Fuchizawa, T | 1 |
| Murakami, G | 1 |
| Miyawaki, T | 1 |
| Huang, SD | 1 |
| Yang, J | 3 |
| Zhang, SY | 1 |
| Tian, LQ | 1 |
| Pan, QH | 1 |
| Chantaphakul, H | 1 |
| Lipworth, B | 1 |
| Boswell-Smith, V | 1 |
| Kuramochi, Y | 1 |
| Yoon, Y | 1 |
| Park, HD | 1 |
| Park, KU | 1 |
| Kim, JQ | 1 |
| Chang, YS | 1 |
| Song, J | 1 |
| Dixon, AE | 2 |
| Kaminsky, DA | 1 |
| Holbrook, JT | 3 |
| Wise, RA | 4 |
| Shade, DM | 3 |
| Irvin, CG | 4 |
| Langen, U | 1 |
| Knopf, H | 1 |
| Melchert, HU | 1 |
| Cohen, RI | 1 |
| Skloot, GS | 1 |
| Smith, LJ | 2 |
| Lima, JJ | 3 |
| Allayee, H | 2 |
| Mastiholimath, VS | 1 |
| Dandagi, PM | 1 |
| Jain, SS | 1 |
| Gadad, AP | 1 |
| Kulkarni, AR | 1 |
| Sagara, H | 3 |
| Komori, M | 1 |
| Matsumoto, T | 2 |
| Fukuyama, S | 1 |
| Matsumura, M | 1 |
| Nakano, T | 1 |
| Tsuda, M | 1 |
| Matsumoto, K | 2 |
| Kanaya, A | 1 |
| Moriwaki, A | 1 |
| Aizawa, H | 3 |
| Yoshida, M | 3 |
| Nakanishi, Y | 1 |
| Chanez, P | 3 |
| Vachier, I | 3 |
| Bourdin, A | 1 |
| Halimi, L | 1 |
| Godard, P | 9 |
| Odajima, Y | 7 |
| Nakano, H | 2 |
| Kato, T | 2 |
| Kondo, N | 4 |
| Katsunuma, T | 2 |
| Morikawa, A | 8 |
| Makino, S | 6 |
| Kihara, N | 3 |
| Nakajima, S | 4 |
| Fukuda, T | 3 |
| Miyamoto, T | 4 |
| Singh, N | 1 |
| Alluri, R | 1 |
| Nair, A | 1 |
| Itoh, Y | 1 |
| Tsurumi, Y | 1 |
| Kimura, T | 3 |
| Takeshita, Y | 1 |
| Tokita, Y | 1 |
| Toya, Y | 1 |
| Umemura, S | 1 |
| Tee, AK | 1 |
| Irving, LB | 1 |
| Hartiala, J | 1 |
| Lee, W | 1 |
| Mehrabian, M | 1 |
| Conti, DV | 1 |
| Okada, K | 2 |
| Eden, E | 1 |
| Brantly, ML | 1 |
| Turino, GM | 1 |
| Indinnimeo, L | 2 |
| Longhi, R | 2 |
| Yang, ZN | 1 |
| Wu, Y | 1 |
| Pu, HP | 1 |
| Krouse, JH | 1 |
| Krouse, HJ | 1 |
| Sankar, J | 1 |
| Lodha, R | 1 |
| Kabra, SK | 1 |
| Ishihara, K | 1 |
| Sano, Y | 3 |
| Taniguchi, H | 2 |
| Nakashima, M | 1 |
| Poon, AH | 1 |
| Tantisira, KG | 1 |
| Litonjua, AA | 1 |
| Lazarus, R | 1 |
| Xu, J | 1 |
| Lasky-Su, J | 1 |
| Hanrahan, JP | 1 |
| Lange, C | 1 |
| Weiss, ST | 2 |
| Mastronarde, JG | 1 |
| Olopade, CO | 1 |
| Scharf, SM | 1 |
| Gupta, P | 1 |
| O'Mahony, MS | 1 |
| Lindholm, B | 2 |
| Helander, E | 1 |
| Siehoff, F | 1 |
| Muysers, K | 1 |
| Worth, G | 1 |
| Gädeke, R | 1 |
| Unger, L | 2 |
| Temple, DE | 2 |
| Brouet, G | 1 |
| Cara, M | 1 |
| Péquignot, H | 1 |
| Munch, JC | 1 |
| Seinfeld, BM | 1 |
| Barlow, PP | 1 |
| Burger, JH | 1 |
| Williams, HO | 1 |
| Pauwels, R | 3 |
| Middleton, E | 10 |
| Gerhard, H | 1 |
| Schachter, EN | 2 |
| Hernandez, E | 1 |
| Angell, CS | 1 |
| Johnson, JW | 1 |
| Collins-Williams, C | 2 |
| Düngemann, H | 1 |
| Borelli, S | 1 |
| Schiess, W | 2 |
| Svedmyr, N | 12 |
| Svedmyr, K | 6 |
| Rosenhall, L | 1 |
| Lönnerholm, G | 4 |
| Foucard, T | 2 |
| Lindström, B | 4 |
| Leffert, F | 2 |
| Eagleton, LE | 1 |
| Kamburoff, PL | 2 |
| Falliers, CJ | 15 |
| Wilson, JD | 3 |
| Sutherland, DC | 4 |
| Thomas, AC | 1 |
| Rea, HH | 2 |
| Morell Brotad, F | 1 |
| Anto Boque, JM | 1 |
| Oriol Sabater, J | 1 |
| Orriols Martínez, R | 1 |
| Hsieh, KH | 1 |
| Anderson, SD | 2 |
| Dolovich, J | 3 |
| Hargreave, FE | 4 |
| Mansmann, HC | 7 |
| Jenne, JW | 5 |
| Smolensky, MH | 17 |
| Reinberg, A | 4 |
| Queng, JT | 1 |
| Georg, J | 2 |
| Craps, L | 2 |
| Greening, AP | 1 |
| Neville, L | 1 |
| Timmers, J | 1 |
| Poole, GW | 1 |
| Davies, D | 1 |
| Seale, JP | 4 |
| Mathieu, M | 2 |
| Cerrina, J | 2 |
| Simonneau, G | 2 |
| Duroux, P | 4 |
| Langaker, KE | 2 |
| Osmundsen, K | 1 |
| Bredesen, JE | 4 |
| Lunde, PK | 2 |
| George, RB | 2 |
| Milner, AD | 2 |
| Nicklas, RA | 2 |
| Whitehurst, VE | 1 |
| Donohoe, RF | 1 |
| Gartmann, J | 1 |
| Schmidt, OP | 1 |
| Lewiston, NJ | 2 |
| Johnson, S | 1 |
| Sloan, E | 1 |
| Vermeire, P | 1 |
| Thompson, PJ | 3 |
| Hay, JG | 1 |
| Hendeles, L | 37 |
| Weinberger, M | 53 |
| Herman, D | 2 |
| Vidart, JN | 1 |
| Schultze-Werninghaus, G | 2 |
| Meier-Sydow, J | 2 |
| Flenley, DC | 3 |
| Primrose, WR | 1 |
| Klein, JJ | 1 |
| Lefkowitz, MS | 1 |
| Spector, SL | 10 |
| Cherniack, RM | 4 |
| Eriksson, NE | 1 |
| Haglind, K | 1 |
| Ewald, U | 1 |
| Rieger, CH | 2 |
| Schwartz, SH | 1 |
| Batstone, GF | 2 |
| Coombes, EJ | 3 |
| Gamlen, TR | 2 |
| Isles, AF | 7 |
| Newth, CJ | 6 |
| Woodcock, AA | 1 |
| Johnson, MA | 1 |
| Geddes, DM | 2 |
| Jäger, L | 2 |
| Bundgaard, A | 3 |
| Galant, SP | 8 |
| Dold, HJ | 1 |
| Schmutzler, W | 1 |
| Zeiger, RS | 2 |
| Shapiro, GG | 17 |
| Bierman, CW | 23 |
| Denning, DW | 1 |
| Cheriyan, G | 1 |
| Tumwine, J | 1 |
| Furukawa, CT | 10 |
| DuHamel, T | 3 |
| Weimer, L | 2 |
| Pierson, WE | 19 |
| Pécoud, A | 1 |
| Van Nierop, JC | 1 |
| Weinstein, AM | 1 |
| Brokaw, A | 1 |
| Vazquez, C | 2 |
| Labayru, T | 1 |
| Rodriguez-Soriano, J | 1 |
| Stablein, JJ | 1 |
| Lockey, RF | 3 |
| Green, ID | 1 |
| Sly, RM | 11 |
| Addis, GJ | 2 |
| Rees, J | 3 |
| Basran, GS | 1 |
| Ball, AJ | 1 |
| Hanson, JM | 1 |
| Morley, J | 3 |
| Turner-Warwick, M | 2 |
| Summers, R | 3 |
| Smith, L | 1 |
| Bardana, EJ | 3 |
| Weinstein, AG | 9 |
| Mellis, CM | 2 |
| Morgan, WJ | 4 |
| Taussig, LM | 2 |
| Stempel, DA | 2 |
| Mellon, M | 2 |
| Smith, NA | 1 |
| Shaw, J | 1 |
| Lustig, JV | 1 |
| Groothuis, JR | 1 |
| Cuddy, PG | 1 |
| Lavietes, MH | 2 |
| Hopewell, PC | 1 |
| Miller, RT | 1 |
| Nowak, RM | 2 |
| Dwyer, JM | 1 |
| Scheinmann, P | 6 |
| Burtin, C | 1 |
| Paupe, H | 1 |
| Lebel, B | 1 |
| Fermanian, J | 1 |
| Bryant, DH | 1 |
| Pui, A | 1 |
| Ziering, RW | 3 |
| Klein, GL | 4 |
| Reinhardt, D | 8 |
| Becker, B | 4 |
| Nagel-Hiemke, M | 1 |
| Matern, M | 1 |
| Wegner, F | 2 |
| Fuchs, F | 1 |
| Martínez Sampere, JJ | 1 |
| Girón, F | 1 |
| Olea, N | 1 |
| Loscertales, M | 1 |
| Ruiz Estremera, A | 1 |
| Puentes, C | 1 |
| Pedraza, V | 1 |
| Weiss, EB | 2 |
| Markowicz, J | 1 |
| Barbero, L | 1 |
| Hegardt, B | 1 |
| Berman, BA | 3 |
| Ross, RN | 2 |
| Morr, H | 1 |
| Heinlein, P | 1 |
| Cummiskey, JM | 1 |
| Popa, V | 1 |
| Lefcoe, NM | 2 |
| Toogood, JH | 4 |
| Blennerhassett, G | 1 |
| Baskerville, J | 1 |
| Paterson, NA | 1 |
| Nolte, D | 6 |
| Rebuck, AS | 2 |
| Gent, M | 2 |
| Chapman, KR | 3 |
| Shohat, B | 3 |
| Volovitz, B | 5 |
| Varsano, I | 6 |
| Kreisman, H | 4 |
| Cohen, C | 1 |
| Ghezzo, H | 3 |
| Vickerson, F | 1 |
| Frank, H | 2 |
| Wolkove, N | 2 |
| Bonstein, HS | 1 |
| Wells, TG | 2 |
| Kearns, GL | 3 |
| Menendez, R | 6 |
| Kelly, HW | 10 |
| Kobayashi, RH | 3 |
| Schuhmacher, P | 1 |
| Fox, A | 1 |
| Stemmann, EA | 1 |
| Stirt, JA | 1 |
| Sullivan, SF | 1 |
| Persson, CG | 10 |
| Hiratani, M | 1 |
| Muto, K | 1 |
| Oshida, Y | 1 |
| Ito, S | 2 |
| Kasei, M | 1 |
| Ueda, S | 1 |
| Sato, T | 1 |
| Scarpace, PJ | 1 |
| Littner, MR | 1 |
| Tashkin, DP | 2 |
| Abrass, IB | 1 |
| Cushley, MJ | 6 |
| Tattersfield, AE | 8 |
| Holgate, ST | 13 |
| Marmo, E | 3 |
| Advenier, C | 1 |
| Davies, PD | 3 |
| Fennerty, AG | 2 |
| Benfield, GF | 1 |
| Parrish, RW | 1 |
| Campbell, IA | 4 |
| Koëter, GH | 2 |
| Meurs, H | 2 |
| Jonkman, JH | 2 |
| Greving, J | 1 |
| Leferink, J | 1 |
| Sluiter, HJ | 1 |
| de Zeeuw, RA | 1 |
| de Vries, K | 1 |
| Haley, TJ | 1 |
| Williams, RL | 1 |
| Upton, RA | 1 |
| Bostrom, A | 1 |
| Busse, WW | 5 |
| Smith, A | 2 |
| Alanko, K | 4 |
| Sahlström, K | 2 |
| Sahay, JN | 1 |
| Chatterjee, SS | 2 |
| Laursen, LC | 9 |
| Johannesson, N | 4 |
| Fagerström, PO | 1 |
| Weeke, B | 10 |
| Fox, RW | 1 |
| Samaan, SS | 1 |
| Bukantz, SC | 2 |
| Loytved, G | 1 |
| Werdermann, K | 1 |
| Jorde, W | 2 |
| Petro, W | 1 |
| Carswell, F | 2 |
| Stratton, D | 2 |
| Hughes, AO | 2 |
| Fysh, WJ | 2 |
| Robinson, P | 2 |
| Chrostowski, K | 1 |
| Ciszek, J | 1 |
| Higgs, CM | 2 |
| Laszlo, G | 2 |
| Kemp, JP | 6 |
| Orgel, HA | 7 |
| Meltzer, EO | 8 |
| Welch, MJ | 6 |
| Voyles, JB | 1 |
| Kropp, R | 1 |
| Aurich, R | 2 |
| Toseland, PA | 1 |
| Wicks, JF | 1 |
| Newall, RG | 1 |
| Mirsching, G | 1 |
| Akoun, G | 1 |
| Battesti, JP | 1 |
| Bignon, J | 1 |
| Caubarrere, I | 1 |
| Charpin, J | 3 |
| Chicou, JF | 1 |
| Herman, DM | 1 |
| Julien, D | 1 |
| Michel, FB | 6 |
| Ellis, EF | 9 |
| Alexander, MR | 1 |
| Taylor, JW | 1 |
| Dull, WL | 1 |
| Kasik, J | 1 |
| Mustion, AL | 1 |
| Kosturkov, G | 2 |
| Staneva, M | 1 |
| Vŭlcheva, T | 1 |
| Mileva, Zh | 2 |
| Gaĭtandzhiev, K | 1 |
| Mosbech, H | 1 |
| Paulsen, H | 1 |
| Søborg, M | 1 |
| Grubbauer, HM | 2 |
| Kump, H | 1 |
| McWilliams, BC | 2 |
| Howick, J | 2 |
| Munn, J | 1 |
| Hakeem, V | 1 |
| Davies, BH | 1 |
| Johno, I | 1 |
| Ogura, Y | 7 |
| Hasegawa, T | 11 |
| Yokochi, Y | 1 |
| Hasegawa, M | 1 |
| Kitazawa, S | 1 |
| Takagi, K | 15 |
| Satake, T | 9 |
| Young, RC | 1 |
| Lucas, SG | 1 |
| Morris, EA | 1 |
| Pittman, J | 1 |
| Rachal, RE | 1 |
| Malveaux, FJ | 2 |
| Booker, WM | 1 |
| Pinnas, JL | 2 |
| Campbell, SC | 1 |
| Cohen, BM | 4 |
| Tinkelman, DG | 15 |
| Edelman, LJ | 1 |
| DeCouto, J | 2 |
| Marquis, NR | 3 |
| Stillwell, PC | 1 |
| Brown, AL | 1 |
| Trang, JM | 1 |
| McConnell, RF | 1 |
| Kluza, RB | 1 |
| Brenner, BE | 2 |
| Branscomb, BV | 1 |
| Elias-Jones, AC | 3 |
| Higenbottam, TW | 2 |
| Barnes, ND | 1 |
| Godden, DJ | 2 |
| Selcow, JE | 2 |
| Mendelson, L | 1 |
| Rosen, JP | 2 |
| Grant, IW | 2 |
| Witek, TJ | 1 |
| Schacter, EN | 1 |
| Dean, NL | 1 |
| Fischer, JF | 1 |
| Meister, W | 4 |
| Mohorn, M | 1 |
| Merlini, M | 3 |
| La Medica, G | 1 |
| Zappa, GP | 1 |
| Fregonese, B | 2 |
| Borzone, A | 1 |
| Macciò, IL | 2 |
| Vallarino, G | 2 |
| Katz, RM | 10 |
| Levison, H | 10 |
| Isles, A | 2 |
| Conway, SP | 2 |
| Gillies, DR | 1 |
| Littlewood, JN | 1 |
| Wiesner, B | 7 |
| Sehrt, I | 4 |
| Iwainsky, H | 5 |
| Price, J | 3 |
| Haig, G | 1 |
| Jones, DK | 1 |
| Elias-Jones, A | 1 |
| Higenbottam, T | 1 |
| Nerminathan, V | 2 |
| McKenzie, SA | 5 |
| Keating, G | 1 |
| Mitchell, EA | 4 |
| Jackson, R | 2 |
| Beaglehole, R | 2 |
| Rea, H | 1 |
| Munro, CS | 1 |
| Prowse, K | 1 |
| Birkett, DJ | 3 |
| Coulthard, KP | 2 |
| Lines, D | 1 |
| Grgurinovich, N | 2 |
| Berdel, D | 7 |
| Heimann, G | 4 |
| Pedersen, S | 11 |
| Holland, A | 1 |
| Duiverman, EJ | 2 |
| Neijens, HJ | 2 |
| Kerrebijn, KF | 4 |
| Scott, PH | 7 |
| Kramer, WG | 2 |
| Harrist, R | 1 |
| Feinmann, R | 1 |
| Datta-Chaudhuri, M | 1 |
| Finlay, M | 1 |
| Kraemer, MJ | 2 |
| Ward, DJ | 1 |
| Cummings, NP | 1 |
| Strunk, RC | 6 |
| Otero, MJ | 7 |
| Barrueco, M | 7 |
| Mariño, EL | 4 |
| Gómez, F | 5 |
| Domínquez-Gil, A | 1 |
| Fiser, PM | 1 |
| Harper, TB | 1 |
| Gaumer, HR | 1 |
| Waring, W | 1 |
| Brannon, RB | 1 |
| Salvaggio, JE | 2 |
| Rasmussen, FV | 2 |
| Madsen, L | 2 |
| Mann, JS | 2 |
| Tuchinda, M | 5 |
| Habanananda, S | 2 |
| Srimaruta, N | 2 |
| Thithapandha, A | 1 |
| Chaichanwathanakul, K | 2 |
| Boe, J | 5 |
| Ljungholm, K | 3 |
| Georgitis, JW | 1 |
| Baswell, B | 1 |
| Shen, DD | 1 |
| Beswick, DT | 1 |
| Cullen, RE | 1 |
| Rylance, GW | 1 |
| Møller-Petersen, J | 1 |
| Søndergaard, I | 2 |
| Schaefers, M | 2 |
| Richter, O | 3 |
| van der Vet, AP | 6 |
| Drost, RH | 4 |
| Kreukniet, J | 7 |
| Maes, RA | 6 |
| Sabaté Salvía, I | 1 |
| Rodríguez Sanchón, B | 1 |
| Barragán Rastrollo, F | 1 |
| Frey González, E | 1 |
| Escarrabill Sanglas, J | 1 |
| Ioli, F | 1 |
| Donner, CF | 1 |
| Fracchia, C | 1 |
| Patessio, A | 1 |
| Aprile, C | 1 |
| Plaza, AM | 1 |
| Farré, C | 1 |
| Giner, MT | 1 |
| Jiménez, CV | 1 |
| Sierra, JI | 1 |
| Takeshi, K | 1 |
| Mizukami, Y | 5 |
| Howard, ML | 1 |
| Baldwin, JN | 2 |
| Jensen, BK | 1 |
| McGeady, SJ | 5 |
| Cluss, PA | 1 |
| Epstein, LH | 1 |
| Galvis, SA | 1 |
| Fireman, P | 2 |
| Friday, G | 1 |
| Morita, Y | 2 |
| Nishida, Y | 1 |
| Kamatani, N | 1 |
| Novembre, E | 1 |
| Veneruso, G | 1 |
| Appendino, C | 1 |
| Vierucci, A | 1 |
| Massey, KL | 2 |
| Gotz, VP | 3 |
| Russell, WL | 2 |
| Green, AW | 2 |
| Ebling, WF | 1 |
| Gardner, MJ | 2 |
| Jusko, WJ | 3 |
| Lopez, LM | 2 |
| Hemmes, RJ | 1 |
| Ryerson, EG | 1 |
| Labayru, MT | 1 |
| Bartolucci, L | 1 |
| Gradoli, C | 1 |
| Vincenzi, V | 1 |
| Iapadre, M | 1 |
| Valori, C | 1 |
| Gayrard, P | 1 |
| Orehek, J | 2 |
| O'Donnell, TV | 2 |
| Geisler, LS | 3 |
| Hertle, F | 1 |
| Ulmer, WT | 1 |
| Wettengel, R | 4 |
| Sybrecht, G | 1 |
| Kemp, M | 2 |
| Tsai, JJ | 1 |
| Wang, SR | 1 |
| Billing, B | 4 |
| Dahlqvist, R | 5 |
| Garle, M | 2 |
| Hörnblad, Y | 3 |
| Ripe, E | 4 |
| Taylor, AJ | 1 |
| Král, B | 1 |
| Eliás, J | 1 |
| Ilnerová, A | 1 |
| Tilser, P | 1 |
| Ilett, KF | 2 |
| Nation, RL | 1 |
| Silbert, B | 1 |
| Oh, TE | 1 |
| Yamakawa, I | 1 |
| Hara, M | 1 |
| Ryuge, K | 3 |
| Wagner, CJ | 1 |
| Danziger, RE | 1 |
| Nelson, HS | 9 |
| Morell, F | 3 |
| Orriols, R | 2 |
| Roca, I | 1 |
| Fraile, M | 2 |
| Laporte, JR | 2 |
| Provotorov, VM | 1 |
| Nikitin, AV | 1 |
| Hirsch, H | 1 |
| Domínguez-Gil, A | 6 |
| Parish, RA | 1 |
| Haulman, NJ | 1 |
| Burns, RM | 1 |
| Nathan, E | 1 |
| de Gracia, J | 2 |
| Vilkka, V | 2 |
| Kulstad, S | 1 |
| Helms, P | 5 |
| Pearl, K | 1 |
| Wilson, R | 2 |
| Watanabe, K | 2 |
| Baculard, A | 2 |
| Morgant, G | 1 |
| Gaultier, C | 2 |
| Boule, M | 1 |
| Tournier, G | 4 |
| Lee, HS | 4 |
| Ngiam, TE | 2 |
| Ho, TF | 1 |
| Koh, PK | 1 |
| Emerman, CL | 1 |
| Tomlanovich, MC | 1 |
| Yanari, S | 1 |
| Sarkar, D | 1 |
| Anderson, JA | 2 |
| Dorow, P | 6 |
| Lines, DR | 2 |
| Grygiel, JJ | 1 |
| Steenhoek, A | 1 |
| Palmen, FM | 1 |
| Elenbaas, RM | 1 |
| Payne, VW | 1 |
| Knott, C | 1 |
| Bateman, M | 1 |
| Reynolds, F | 1 |
| Chervinsky, P | 2 |
| Noyes, JH | 1 |
| Mingo, TS | 1 |
| Dardick, KR | 1 |
| Bauman, JH | 1 |
| Teichman, S | 1 |
| Wible, DA | 1 |
| Tønnesen, J | 1 |
| Berquist, WE | 1 |
| Rachelefsky, GS | 11 |
| Rowshan, N | 1 |
| Siegel, S | 3 |
| Katz, R | 2 |
| Welch, M | 1 |
| Becker, AB | 2 |
| Simons, KJ | 6 |
| Gillespie, CA | 3 |
| Simons, FE | 10 |
| Rowe, MS | 1 |
| MacKechnie, HL | 1 |
| Brown, PJ | 1 |
| Greville, HW | 1 |
| Finucane, KE | 1 |
| Chaintreuil, J | 1 |
| Bensadoun, J | 1 |
| Parelon, G | 1 |
| de Paulet, AC | 1 |
| O'Rourke, PP | 1 |
| Crone, RK | 1 |
| Waldorff, S | 1 |
| Courteheuse, C | 1 |
| Kandt, D | 1 |
| Chryssanthopoulos, C | 3 |
| Maksud, MG | 2 |
| Gallen, WG | 1 |
| Hause, LL | 2 |
| Rankin, JA | 1 |
| Snyder, PE | 1 |
| Matthay, RA | 3 |
| Uden, DL | 2 |
| Wyatt, RA | 3 |
| Zaske, DE | 2 |
| Wilkens, JH | 3 |
| Neuenkirchen, H | 2 |
| Sybrecht, GW | 12 |
| Oellerich, M | 5 |
| Nissen, P | 1 |
| Rogers, RJ | 3 |
| Dawson, KP | 2 |
| Fergusson, DM | 1 |
| Arens, PJ | 1 |
| Clark, TJ | 3 |
| Van der Meer, YG | 1 |
| Van Alphen, AC | 1 |
| Van Altena, R | 1 |
| Van Loenen, AC | 1 |
| Jørstad, SO | 1 |
| Omenaas, E | 1 |
| Ogilvie, RI | 4 |
| Godfrey, S | 10 |
| Guy, H | 1 |
| Trembath, PW | 1 |
| Levin, A | 1 |
| Eigen, H | 3 |
| Gonzalez, P | 1 |
| Ahrens, R | 2 |
| Glass, J | 1 |
| Archer, LN | 1 |
| Adams, W | 1 |
| Simpson, H | 1 |
| Libby, D | 1 |
| Fischer, TJ | 1 |
| Hunter, RH | 1 |
| Wilson, N | 1 |
| Silverman, M | 1 |
| Kaiser, HB | 2 |
| Urbanek, R | 2 |
| Newth, CV | 1 |
| Turner, JA | 1 |
| Prenner, BM | 1 |
| Debelić, M | 2 |
| Rosenberry, KR | 1 |
| Defusco, CJ | 1 |
| White, JD | 1 |
| Blumenthal, I | 1 |
| Picado, C | 3 |
| Montserrat, JM | 1 |
| Roca, J | 1 |
| Rodríguez-Roisín, R | 1 |
| Estopá, R | 1 |
| Xaubet, A | 1 |
| Marín, A | 1 |
| Agustí-Vidal, A | 2 |
| Brown, DL | 1 |
| Maddux, MS | 1 |
| Organek, HW | 1 |
| Bauman, JL | 1 |
| Siegel, SC | 9 |
| Mickey, R | 1 |
| Lotner, GZ | 1 |
| Vanderpool, GE | 2 |
| Carroll, S | 1 |
| Spangler, DL | 3 |
| Laufer, P | 1 |
| Torphy, DE | 1 |
| Pleskow, WW | 1 |
| Stevenson, DD | 2 |
| Mathison, DA | 1 |
| Simon, RA | 1 |
| Hansen, HM | 1 |
| Kampmann, JP | 1 |
| Angelo, HR | 1 |
| Christensen, JM | 1 |
| de Blic, J | 5 |
| Brouard, JJ | 1 |
| Benoist, MR | 2 |
| Paupe, J | 4 |
| Ruff, F | 4 |
| Taylor, DR | 1 |
| Kinney, CD | 1 |
| McDevitt, DG | 3 |
| Delahunty, TJ | 1 |
| Andrasch, RH | 1 |
| Fiel, SB | 1 |
| Swartz, MA | 1 |
| Glanz, K | 1 |
| Francis, ME | 1 |
| Magnussen, H | 9 |
| Macha, HN | 1 |
| Utama, I | 2 |
| Meering, PG | 1 |
| Fokkens, J | 1 |
| Serra, R | 1 |
| Schuller, DE | 2 |
| Eitner, L | 1 |
| Schnitker, J | 1 |
| Charles, BG | 1 |
| Ravenscroft, PJ | 1 |
| Bochner, F | 1 |
| Webber-Jones, JE | 1 |
| Bryant, MK | 1 |
| Gever, LN | 1 |
| Rogers, TR | 1 |
| Texier, F | 2 |
| Vallarino, R | 1 |
| Liang, AY | 1 |
| Jones, DT | 1 |
| Sears, MR | 4 |
| Hamilton, W | 1 |
| Lawyer, C | 2 |
| Auer, S | 1 |
| Brottem, J | 1 |
| Bardana, E | 1 |
| Hirshman, C | 1 |
| Lynn, R | 1 |
| Downes, H | 2 |
| Sheen, A | 4 |
| Anderson, K | 1 |
| Holbrook, P | 1 |
| Schwartz, AL | 1 |
| Lipton, JM | 1 |
| Warburton, D | 1 |
| Johnson, LB | 1 |
| Twarog, FJ | 2 |
| Groggins, RC | 1 |
| Lenney, W | 1 |
| Stokes, GM | 1 |
| Fairfax, AJ | 2 |
| McNabb, WR | 1 |
| Davies, HJ | 1 |
| Spiro, SG | 1 |
| Nassif, EG | 2 |
| Thompson, R | 1 |
| Huntley, W | 1 |
| Smith, JA | 1 |
| Weber, RW | 4 |
| Klaustermeyer, WB | 2 |
| Kuhn, GJ | 2 |
| Santiago, SM | 2 |
| Wehiky, I | 1 |
| Hunt, EJ | 1 |
| Weliky, I | 1 |
| Grassi, C | 2 |
| Casali, L | 2 |
| Rampulla, C | 2 |
| Rossi, A | 2 |
| Van Asperen, PP | 1 |
| South, RT | 1 |
| Simpsom, SJ | 1 |
| McPhillips, JJ | 1 |
| Smith, K | 1 |
| Brandl, M | 1 |
| Beer, S | 2 |
| Hamer, P | 1 |
| Muittari, A | 4 |
| Allonen, H | 2 |
| Cho, YW | 3 |
| Han, HC | 2 |
| OH, SY | 2 |
| Maines, JE | 1 |
| Kuemmerle, HP | 2 |
| Kanto, J | 3 |
| Kulmala, T | 1 |
| Mäntylä, R | 1 |
| Tala, E | 1 |
| Pollert, I | 1 |
| Klein, H | 1 |
| Dusdieker, L | 1 |
| Green, M | 3 |
| Smith, GD | 3 |
| Ekwo, EE | 1 |
| Kügler, D | 1 |
| Nolan, G | 1 |
| Mindorff, C | 1 |
| Reilly, PA | 1 |
| Iafrate, RP | 2 |
| Robinson, JD | 2 |
| Lupkiewicz, SM | 1 |
| Koup, JR | 2 |
| Gibaldi, M | 1 |
| Fuquay, D | 1 |
| Oppenheimer, PJ | 1 |
| Cabanas, R | 3 |
| Peña, JU | 1 |
| Castro-Gago, M | 3 |
| Tojo, J | 1 |
| Labovitz, E | 1 |
| Spector, S | 2 |
| Fanta, CH | 4 |
| Rossing, TH | 4 |
| McFadden, ER | 8 |
| Mungall, D | 1 |
| Bancroft, W | 1 |
| Marshall, J | 1 |
| Tabachnik, E | 4 |
| Scott, P | 1 |
| Correia, J | 3 |
| MacLeod, S | 2 |
| Newth, C | 2 |
| Boggs, PB | 1 |
| Hughey, MC | 1 |
| Yost, RL | 1 |
| Harman, EM | 2 |
| Yahav, Y | 1 |
| Katznelson, D | 2 |
| Benzaray, S | 1 |
| Laver, J | 1 |
| Benson, L | 1 |
| Cotariu, D | 1 |
| Neli, P | 1 |
| Saidman, JL | 1 |
| Viure, E | 1 |
| Hemstreet, MP | 2 |
| Miles, MV | 2 |
| Rutland, RO | 1 |
| Feldman, CH | 2 |
| Hutchinson, VE | 1 |
| Sher, TH | 1 |
| Feldman, BR | 3 |
| Davis, WJ | 3 |
| Lam, C | 1 |
| Ben-Zvi, Z | 2 |
| Barnett, S | 1 |
| Kattan, M | 1 |
| Fenje, PC | 1 |
| Baltodano, A | 1 |
| MacLeod, SM | 4 |
| Soldin, S | 1 |
| Fischer, RG | 1 |
| Booth, BH | 1 |
| Mitchell, DQ | 1 |
| Kibbe, AH | 1 |
| Richer, C | 1 |
| Bah, H | 1 |
| Thuillez, C | 1 |
| Giudicelli, JF | 1 |
| Kyong, CU | 1 |
| Ponce, BE | 1 |
| Fudenberg, HH | 1 |
| Glassman, AB | 1 |
| Mohrmann, ME | 1 |
| Peña, J | 2 |
| Fuster, M | 2 |
| Cortizo, E | 2 |
| Couselo, JM | 1 |
| Tojo, R | 2 |
| Bronsky, EA | 3 |
| Durkee, JD | 1 |
| Simmons, SM | 1 |
| Camp, RB | 1 |
| Mungall, DR | 1 |
| Bailey, WC | 1 |
| Anolik, R | 2 |
| Kolski, GB | 5 |
| Schaible, DH | 1 |
| Ratner, J | 1 |
| Blaive, B | 3 |
| Bugnas, B | 2 |
| Lapalus, P | 2 |
| Lemoigne, F | 3 |
| Luciuk, GH | 1 |
| Shridharani, M | 1 |
| Maxson, TR | 1 |
| Bauer, P | 1 |
| Windorfer, A | 1 |
| Alterthum, K | 1 |
| Müller, G | 1 |
| Lockhart, JA | 1 |
| Katsampes, CP | 2 |
| Evans, HE | 1 |
| Marquis, JF | 1 |
| Carruthers, SG | 1 |
| Spence, JD | 1 |
| Brownstone, YS | 1 |
| Fox, J | 1 |
| Hicks, P | 1 |
| Higbee, MD | 1 |
| Ziment, I | 2 |
| Mellstrand, T | 2 |
| Chang, KC | 2 |
| Chai, H | 9 |
| Miles-Lawrence, R | 1 |
| Bell, TD | 5 |
| Pinney, CT | 1 |
| Bölcskei, P | 1 |
| Miller, KA | 1 |
| Smith, G | 2 |
| Pingleton, SK | 1 |
| Awaya, M | 3 |
| Zugić, M | 1 |
| Varagić, VM | 3 |
| Vasileva, S | 1 |
| Dimitrov, V | 1 |
| Slavov, S | 1 |
| Bolme, P | 2 |
| Eriksson, M | 2 |
| Paalzow, L | 2 |
| Albertini, M | 1 |
| Maurin, S | 1 |
| Boutte, P | 1 |
| Mariani, R | 1 |
| de la Morena, E | 2 |
| Borges, MT | 1 |
| García Rebollar, DC | 1 |
| Escorihuela, R | 2 |
| Cuena Boy, R | 1 |
| Honorato Pérez, JM | 1 |
| Azanza Perea, JR | 1 |
| Reeves, SE | 1 |
| Morrow, ME | 1 |
| Halkin, H | 1 |
| Mazar, A | 3 |
| Almog, S | 1 |
| Schnaps, Y | 1 |
| Moeller-Petersen, J | 1 |
| Robbins, JJ | 1 |
| Llerena, P | 1 |
| Royo, F | 1 |
| Lillo Lillo, M | 1 |
| Borges Domingo, T | 1 |
| López-Linares, M | 1 |
| Tinkelman, D | 5 |
| Suess, WM | 2 |
| Krivoy, N | 2 |
| Alroy, G | 1 |
| Eggleston, PA | 3 |
| Beasley, PP | 1 |
| Kindley, RT | 1 |
| Hirshman, CA | 1 |
| Farbood, A | 1 |
| Rodgers, R | 2 |
| Gerber, N | 2 |
| Frigas, E | 1 |
| Filley, WV | 1 |
| Reed, CE | 8 |
| Munch, EP | 1 |
| Carroll, W | 1 |
| Stempel, D | 1 |
| Cloutier, MM | 1 |
| Loughlin, GM | 2 |
| Wong, L | 1 |
| LaForce, CF | 2 |
| Miller, MF | 1 |
| Goldsworthy, SJ | 1 |
| Warner, JO | 1 |
| Bellon, G | 2 |
| Plasse, JC | 2 |
| Satta, S | 1 |
| Barbier, Y | 1 |
| Gilly, R | 2 |
| Vázquez, MC | 1 |
| Dettmer, HH | 1 |
| May, DC | 1 |
| Roe, EJ | 1 |
| Jarboe, CH | 3 |
| Vaughan, L | 1 |
| Bruner, JM | 1 |
| Arnold, JD | 1 |
| Hill, GN | 1 |
| Sansom, LN | 1 |
| Johnston, A | 2 |
| Culig, J | 1 |
| Turner, P | 4 |
| Racineux, JL | 1 |
| Troussier, J | 1 |
| Turcant, A | 1 |
| Tuchais, E | 1 |
| Allain, P | 1 |
| König, P | 5 |
| Schneck, DW | 1 |
| Di Mezza, F | 1 |
| Giordano, L | 1 |
| Scognamiglio, M | 1 |
| Montanaro, A | 1 |
| Selvig, K | 2 |
| Alme, A | 1 |
| Rugstad, HE | 2 |
| Aas, K | 2 |
| Bjerve, KS | 2 |
| Ufkes, JG | 1 |
| Leeuwin, RS | 1 |
| Ottenhof, M | 1 |
| Zeegers, A | 1 |
| Zuidema, J | 2 |
| Trautlein, JJ | 1 |
| Demers, L | 1 |
| Esler, V | 1 |
| Field, E | 1 |
| Anderson, G | 1 |
| Koup, J | 1 |
| Slaughter, R | 1 |
| Edwards, WD | 1 |
| Resman, B | 1 |
| Hook, E | 1 |
| Masaki, T | 1 |
| Sekine, H | 1 |
| Iikura, Y | 8 |
| Tomita, Y | 1 |
| Asano, T | 1 |
| Kajita, T | 1 |
| Seo, K | 1 |
| Pietruszewska, E | 1 |
| Droszcz, W | 7 |
| Wrońska, J | 3 |
| Kowalski, J | 1 |
| Kjellin, G | 2 |
| Erjefält, I | 2 |
| Karlsson, JA | 1 |
| Zarceansky, S | 1 |
| Yahav, I | 1 |
| Dani, S | 1 |
| Terral, C | 1 |
| Selles, JP | 1 |
| Chipps, BE | 1 |
| Sobotka, AK | 1 |
| Sanders, JP | 1 |
| Teets, KC | 1 |
| Norman, PS | 1 |
| Lichtenstein, LM | 1 |
| Pollowitz, JA | 1 |
| Klein, G | 1 |
| Depew, CC | 1 |
| Scherr, MS | 1 |
| Scherr, LB | 1 |
| Morton, JL | 1 |
| Brossmann, D | 1 |
| Ruf, G | 1 |
| Wiessmann, KJ | 1 |
| Loren, ML | 2 |
| Kirsten, EB | 1 |
| Husain, A | 1 |
| Chapel, J | 1 |
| Malek-Ahmadi, P | 1 |
| Lawyer, CH | 1 |
| Honicky, RE | 1 |
| Imhof, K | 1 |
| Scherrer, M | 5 |
| Carroll, MS | 2 |
| Page, EG | 1 |
| Redding, MA | 2 |
| Rothstein, RJ | 2 |
| Lena, SM | 1 |
| Hutchins, P | 1 |
| Wood, CB | 1 |
| Pertusini, B | 1 |
| Zwick, H | 1 |
| Buckley, JM | 1 |
| Canavan, JW | 1 |
| Ellerstein, NS | 1 |
| Sullivan, TD | 1 |
| Murphy, S | 6 |
| Miller, R | 3 |
| Brandon, ML | 2 |
| Newman, LJ | 1 |
| Richards, W | 5 |
| Church, JA | 2 |
| Borzy, MS | 1 |
| Stec, GP | 1 |
| Greenberger, P | 1 |
| Ruo, TI | 2 |
| Henthorn, T | 1 |
| Atkinson, AJ | 2 |
| Patterson, R | 3 |
| Deutsch, RI | 1 |
| Simmons, M | 1 |
| Calvarese, B | 1 |
| Wanger, J | 1 |
| Lee, YE | 1 |
| O'Brien, SR | 1 |
| Hein, EW | 3 |
| Goldstein, DH | 1 |
| Snapper, JR | 1 |
| Josephson, GW | 1 |
| Kennedy, HL | 1 |
| MacKenzie, EJ | 1 |
| Gibson, G | 1 |
| Madsen, BW | 1 |
| Tarala, RA | 3 |
| Paterson, JW | 11 |
| Bachofen, H | 1 |
| Kyd, K | 2 |
| Ahrens, J | 2 |
| Röthlisberger, U | 1 |
| Mickey, MR | 3 |
| Kadlec, GJ | 3 |
| Sublett, J | 1 |
| Pollard, S | 1 |
| Ha, L | 1 |
| Ellenberg, D | 1 |
| Karibo, JM | 3 |
| Simon, T | 1 |
| Katsampes, C | 2 |
| Stein, MR | 2 |
| Towner, TG | 1 |
| Mansfield, LE | 2 |
| Jacobson, KW | 1 |
| McDonnell, JT | 1 |
| Sarrazin, E | 1 |
| Muir, K | 1 |
| Riegelman, S | 3 |
| Murphy, MB | 1 |
| Dillon, A | 1 |
| Fitzgerald, MX | 2 |
| Gurwitz, D | 1 |
| Valia, KH | 1 |
| Hartman, CA | 1 |
| Kucharczyk, N | 1 |
| Sofia, RD | 2 |
| Weinberger, MM | 8 |
| Shannon, D | 1 |
| Guiang, SF | 1 |
| Jimenez, D | 1 |
| Ekwo, E | 2 |
| Holle, JP | 1 |
| Hartmann, V | 2 |
| Hadley, WM | 1 |
| Murphy, SA | 1 |
| Skipper, BG | 1 |
| Korppi, M | 2 |
| Kuikka, L | 1 |
| Remes, K | 1 |
| Hossain, M | 2 |
| Okubo, Y | 3 |
| Sekiguchi, M | 2 |
| Ahrens, RC | 5 |
| Milgrom, H | 5 |
| Bender, B | 4 |
| Welch, JS | 1 |
| Edwards, TB | 1 |
| Dockhorn, RJ | 2 |
| Wagner, DE | 1 |
| Fiddes, RA | 1 |
| Grossman, J | 2 |
| Southern, DL | 1 |
| Cefali, EA | 1 |
| Hassanein, RS | 1 |
| Banner, KH | 2 |
| Vichyanond, P | 2 |
| Aranyanark, N | 1 |
| Visitsuntorn, N | 1 |
| Berkowitz, RB | 1 |
| Marcoux, JP | 1 |
| Rooklin, AR | 2 |
| Zeitz, HJ | 1 |
| Moss, BA | 2 |
| Hubbard, RC | 1 |
| Lorber, RR | 1 |
| Bender, BG | 5 |
| Lanier, BQ | 1 |
| Lemanske, RF | 1 |
| Skoner, DP | 2 |
| Sleiman, C | 1 |
| Mal, H | 1 |
| Roué, C | 1 |
| Fournier, M | 1 |
| Pariente, R | 1 |
| Alba, F | 1 |
| Madridejos, R | 1 |
| Gimeno, J | 1 |
| González, M | 1 |
| Djukanović, R | 4 |
| Finnerty, JP | 2 |
| Lee, C | 2 |
| Wilson, S | 2 |
| Madden, J | 2 |
| D'Alonzo, GE | 11 |
| Steinijans, VW | 16 |
| Keller, A | 7 |
| Saeed, SA | 1 |
| Ali, N | 1 |
| Saleem, S | 1 |
| Kakhnovskiĭ, IM | 1 |
| Solomatin, AS | 1 |
| Vdovina, TI | 1 |
| Geist, C | 1 |
| Schneider, J | 1 |
| Zimmer, O | 1 |
| Lagente, V | 1 |
| Hichami, A | 1 |
| Boichot, E | 1 |
| Martins, MA | 1 |
| Silva, PM | 1 |
| Delaval, P | 1 |
| Desrues, B | 1 |
| Delaval, Y | 1 |
| Lena, H | 1 |
| Aoki, T | 1 |
| Iwase, M | 1 |
| Watanabe, T | 2 |
| Miyaguchi, K | 1 |
| Hayashi, H | 1 |
| Yokota, M | 2 |
| Youngchaiyud, P | 1 |
| Permpikul, C | 1 |
| Suthamsmai, T | 1 |
| Wong, E | 1 |
| Vagaggini, B | 1 |
| Paggiaro, PL | 2 |
| Bancalari, L | 1 |
| Di Franco, A | 2 |
| Giannini, D | 2 |
| Bacci, E | 1 |
| Carrara, M | 1 |
| Dente, FL | 1 |
| Giuntini, C | 1 |
| Ringel, S | 1 |
| Barr, J | 1 |
| Katz, Y | 1 |
| Kidney, J | 1 |
| Dominguez, M | 1 |
| Taylor, PM | 1 |
| Rose, M | 1 |
| Eseverri, JL | 1 |
| Botey, J | 1 |
| Marin, AM | 1 |
| Santing, RE | 1 |
| Olymulder, CG | 1 |
| Van der Molen, K | 1 |
| Zaagsma, J | 1 |
| Napier-Flood, FE | 1 |
| Creese, BR | 1 |
| Dekhuijzen, PN | 1 |
| van der Heijden, HF | 1 |
| van Herwaarden, CL | 1 |
| Ferrari, M | 2 |
| Olivieri, M | 2 |
| Lampronti, G | 2 |
| Biasin, C | 2 |
| Lo Cascio, V | 2 |
| Aubier, M | 1 |
| Matthys, H | 5 |
| Müller, S | 1 |
| Herceg, R | 1 |
| Bijl, D | 1 |
| Speelberg, B | 2 |
| Tanaka, I | 2 |
| Hiraga, Y | 2 |
| Inaba, J | 1 |
| Fujino, M | 2 |
| Kobayashi, K | 2 |
| Tsai, J | 1 |
| Chern, TL | 1 |
| Hu, SC | 1 |
| Lee, CH | 1 |
| Wang, RB | 1 |
| Deng, JF | 1 |
| Weldon, DP | 1 |
| Abramson, MJ | 2 |
| Kutin, JJ | 1 |
| Rosier, MJ | 1 |
| Bowes, G | 2 |
| Casha, P | 1 |
| Bernard, O | 1 |
| Galland, MC | 1 |
| Pisano, P | 1 |
| Koné-Paut, I | 1 |
| Vialet, R | 1 |
| Durand, A | 2 |
| Bernard, JL | 1 |
| Rivington, RN | 4 |
| Boulet, LP | 2 |
| Côté, J | 1 |
| Small, DI | 1 |
| Alexander, M | 1 |
| Day, A | 1 |
| Harsanyi, Z | 1 |
| Darke, AC | 1 |
| Harman, E | 2 |
| Huang, D | 1 |
| O'Brien, R | 1 |
| Blake, K | 2 |
| Delafuente, J | 1 |
| Quek, SC | 1 |
| Chong, A | 1 |
| Connett, GJ | 1 |
| Lee, BW | 1 |
| Yamazaki, M | 3 |
| Fukutomi, O | 2 |
| Kato, Z | 2 |
| Nakashima, Y | 1 |
| Shinoda, S | 1 |
| Agata, H | 1 |
| Kondo, T | 2 |
| Imaeda, N | 2 |
| Orii, T | 2 |
| Stenius-Aarniala, B | 2 |
| Riikonen, S | 1 |
| Teramo, K | 1 |
| Shimizu, T | 6 |
| Maeda, S | 4 |
| Mochizuki, H | 5 |
| Tokuyama, K | 6 |
| Rosenfield, DB | 1 |
| McCarthy, M | 1 |
| McKinney, K | 1 |
| Viswanath, NS | 1 |
| Nudelman, HB | 1 |
| Shendurnikar, N | 1 |
| Oberbauer, B | 1 |
| Nicolai, T | 1 |
| von Mutius, E | 1 |
| Coffey, MJ | 1 |
| Sanders, G | 1 |
| Eschenbacher, WL | 1 |
| Tsien, A | 1 |
| Ramesh, S | 1 |
| Toews, GB | 1 |
| McCune, WJ | 1 |
| Banner, AS | 1 |
| Gianaris, PG | 1 |
| Golish, JA | 1 |
| Newnham, DM | 1 |
| Coutie, WJ | 1 |
| Sullivan, P | 3 |
| Bekir, S | 1 |
| Jaffar, Z | 1 |
| Jeffery, P | 1 |
| Costello, J | 3 |
| Self, T | 1 |
| Abou-Shala, N | 2 |
| Sunman, W | 1 |
| Dzyngel, B | 1 |
| Kesten, S | 1 |
| Taburet, AM | 1 |
| Schmit, B | 1 |
| Ramadan, F | 1 |
| Fiocchi, A | 1 |
| Alessandro, F | 1 |
| Zuccotti, GV | 1 |
| Vincenzo, ZG | 1 |
| Sala, M | 1 |
| Marco, S | 1 |
| Giovannini, M | 1 |
| Marcello, G | 1 |
| Riva, E | 1 |
| Enrica, R | 1 |
| Bowton, DL | 1 |
| Stump, DA | 1 |
| Anderson, R | 1 |
| Kuroume, T | 3 |
| Louis, R | 3 |
| Bury, T | 1 |
| Radermecker, M | 3 |
| Maxwell-Rubin, M | 1 |
| Paap, CM | 1 |
| Godley, PJ | 1 |
| Kallen, A | 1 |
| Gourgoulianis, KI | 1 |
| Lavdas, E | 1 |
| Mizios, P | 1 |
| Li, Z | 1 |
| Chen, G | 2 |
| Khan, MM | 1 |
| Fjellbirkeland, L | 1 |
| Gulsvik, A | 1 |
| Palmer, JB | 1 |
| Kanthawatana, S | 2 |
| McCubbin, M | 2 |
| Bronsky, E | 2 |
| Kelloway, JS | 1 |
| Adlis, SA | 1 |
| Burgess, C | 2 |
| Pearce, N | 2 |
| Thiruchelvam, R | 1 |
| Wilkinson, R | 1 |
| Linaker, C | 1 |
| Woodman, K | 1 |
| Crane, J | 2 |
| Beasley, R | 2 |
| Pauwels, RA | 3 |
| Ashida, Y | 1 |
| Tsukuda, R | 1 |
| Cebollero Rivas, P | 1 |
| Garisa Rocha, R | 1 |
| Bazo Fernández, E | 1 |
| Colás Sanz, C | 1 |
| Duce Gracia, F | 1 |
| Okabe, T | 1 |
| Hida, M | 1 |
| Maruyama, K | 1 |
| Kohgo, T | 1 |
| Shibuya, M | 1 |
| Ohashi, A | 1 |
| Kaarsgaren, RJ | 1 |
| Zijlstra, RF | 1 |
| Annett, RD | 1 |
| Virchow, JC | 2 |
| Oehling, A | 1 |
| Boer, L | 1 |
| Werner, P | 1 |
| Blaser, K | 1 |
| Walker, C | 1 |
| Boznański, A | 2 |
| Domanasiewicz, M | 1 |
| Rudzka, D | 1 |
| Pirogowicz, I | 1 |
| Stewart, GE | 1 |
| Diaz, JD | 1 |
| Seleznick, MJ | 1 |
| Trudeau, WL | 1 |
| Ledford, DK | 1 |
| Wasserman, SI | 2 |
| Reisman, JJ | 1 |
| Scarpinato, L | 1 |
| Purdom, D | 1 |
| Stoloff, SW | 1 |
| Chand, N | 1 |
| Harrison, JE | 1 |
| Rooney, SM | 1 |
| Nolan, KW | 1 |
| De Vine, CL | 1 |
| Jakubicki, RG | 1 |
| Pillar, J | 1 |
| Diamantis, W | 1 |
| Hervé, P | 1 |
| Escourrou, P | 1 |
| Gandolfo, JY | 1 |
| Charlery, S | 1 |
| Denjean, A | 1 |
| Petitpretz, P | 1 |
| Thomsen, M | 1 |
| Zahn, T | 2 |
| Chazan, R | 5 |
| Karwat, K | 1 |
| Tymińska, K | 2 |
| Tadeusiak, W | 1 |
| Eneser, M | 1 |
| Snell, NJ | 1 |
| Toba, T | 1 |
| Kurosaki, T | 1 |
| Ohta, F | 1 |
| Tamai, K | 1 |
| Ikegami, H | 1 |
| Saitoh, Y | 1 |
| Matsuka, Y | 1 |
| Makino, K | 1 |
| Asai, T | 1 |
| Bland, JM | 1 |
| Thompson, JM | 1 |
| Ueno, K | 3 |
| Tanaka, K | 3 |
| Shiokawa, M | 1 |
| Horiuchi, Y | 3 |
| Amir, J | 1 |
| Malik, H | 1 |
| Lerman, M | 1 |
| Hogue, SL | 1 |
| Phelps, SJ | 1 |
| Smolensky, M | 1 |
| Knutsen, R | 1 |
| Bøhmer, T | 1 |
| Falch, J | 1 |
| Dent, G | 3 |
| Tsoĭ, AN | 6 |
| Bogovskiĭ, BP | 3 |
| Saprygina, TV | 1 |
| Kniazev, RM | 1 |
| Titova, EV | 1 |
| Kukes, VG | 3 |
| Salikova, VV | 1 |
| Nonikov, VE | 1 |
| Belousov, IuB | 4 |
| Cox, S | 1 |
| Webster, M | 1 |
| Walson, PD | 2 |
| Epstein, PE | 1 |
| Lewis, LD | 1 |
| Essex, E | 2 |
| Volans, GN | 1 |
| Cochrane, GM | 6 |
| Bosco, LA | 1 |
| Gerstman, BB | 1 |
| Tomita, DK | 1 |
| Kramer, MS | 1 |
| Baraka, A | 1 |
| Darwish, R | 1 |
| Rizkallah, P | 1 |
| Rasmussen, KG | 1 |
| Zorumski, CF | 1 |
| Ikeda, A | 1 |
| Senju, S | 1 |
| Toyoshima, H | 1 |
| Miyahara, S | 1 |
| Aritomi, T | 1 |
| Ishibashi, M | 1 |
| Ostrom, NK | 1 |
| Romero, L | 1 |
| Klinger, N | 1 |
| McCarville, S | 1 |
| Harrison, LI | 3 |
| Osborne, ML | 1 |
| Wall, M | 1 |
| Mahr, TA | 1 |
| Evans, R | 2 |
| Soferman, R | 1 |
| Tal, A | 4 |
| Schlessinger, M | 1 |
| Rotchild, M | 1 |
| Nagahama, H | 1 |
| Nagano, K | 1 |
| Yamanaka, I | 1 |
| Kasagawa, J | 1 |
| Seki, I | 1 |
| Suzuki, Y | 1 |
| Mamełka, B | 1 |
| Chciałowski, A | 1 |
| Włodarczyk, R | 1 |
| Yano, I | 1 |
| Tanigawara, Y | 2 |
| Yasuhara, M | 1 |
| Mikawa, H | 2 |
| Hori, R | 2 |
| Cortijo, J | 1 |
| Bou, J | 1 |
| Beleta, J | 1 |
| Cardelús, I | 1 |
| Llenas, J | 1 |
| Morcillo, E | 1 |
| Gristwood, RW | 2 |
| Middle, MV | 1 |
| Müller, FO | 1 |
| Schall, R | 1 |
| Le Roux, FP | 1 |
| du Plessis, JB | 1 |
| Köhler, E | 3 |
| Sollich, V | 4 |
| Schuster, R | 4 |
| Jain, NK | 1 |
| Sharma, SD | 1 |
| Garg, VK | 1 |
| Sharma, TN | 1 |
| Devpura, K | 1 |
| Hashimoto, K | 1 |
| Akimoto, K | 1 |
| Ebisawa, M | 1 |
| Muir, JF | 4 |
| Peiffer, G | 1 |
| Richard, MO | 2 |
| Benhamou, D | 1 |
| Andrejak, M | 2 |
| Hary, L | 1 |
| Moore, N | 1 |
| DiGiulio, GA | 1 |
| Kercsmar, CM | 1 |
| Krug, SE | 1 |
| Alpert, SE | 1 |
| Marx, CM | 1 |
| Carter, E | 1 |
| Cruz, M | 1 |
| Chesrown, S | 1 |
| Shieh, G | 1 |
| Reilly, K | 1 |
| Ward, AJ | 1 |
| McKenniff, M | 1 |
| Evans, JM | 1 |
| Costello, JF | 2 |
| Shilalukey, K | 1 |
| Robieux, I | 1 |
| Spino, M | 1 |
| Greenwald, M | 1 |
| Shear, N | 1 |
| Koren, G | 1 |
| Thal, W | 3 |
| Nasser, SS | 1 |
| Rees, PJ | 2 |
| Delport, R | 4 |
| Ubbink, JB | 4 |
| Vermaak, WJ | 3 |
| Becker, PJ | 2 |
| Chilmonczyk, BA | 1 |
| Salmun, LM | 1 |
| Megathlin, KN | 1 |
| Neveux, LM | 1 |
| Palomaki, GE | 1 |
| Knight, GJ | 1 |
| Pulkkinen, AJ | 1 |
| Haddow, JE | 1 |
| Holzer, R | 1 |
| Hasani, A | 1 |
| Agnew, JE | 1 |
| Pavia, D | 1 |
| Vora, H | 1 |
| Clarke, SW | 1 |
| Carsuzaa, F | 1 |
| Schranz, J | 1 |
| Casner, PR | 1 |
| Reilly, R | 1 |
| Ho, H | 1 |
| Morley, TE | 1 |
| Brown, AC | 1 |
| Offord, KP | 2 |
| Maegaki, Y | 1 |
| Koeda, T | 1 |
| Kawahara, H | 1 |
| Takeshita, K | 1 |
| Gazca Aguilar, A | 1 |
| del Río Navarro, B | 1 |
| Sienra Monge, JJ | 1 |
| Linares Zapien, FJ | 1 |
| Atsmon, J | 1 |
| Priel, IE | 1 |
| Dolev, E | 1 |
| Binet, JL | 1 |
| Mentz, F | 1 |
| Baudet, S | 1 |
| Ouaaz, F | 1 |
| Merle-Béral, H | 1 |
| Haen, E | 1 |
| Komada, F | 1 |
| Iwai, T | 1 |
| Maekawa, H | 1 |
| Okumura, K | 1 |
| Morris, A | 1 |
| Melamed, J | 1 |
| Beaucher, WN | 1 |
| Pedersen, B | 2 |
| Karlström, R | 1 |
| Peterson, CG | 1 |
| Ohtake, H | 1 |
| Misaki, T | 1 |
| Matsunaga, Y | 1 |
| Tubota, M | 1 |
| Kawasuji, M | 1 |
| Kraft, M | 2 |
| Torvik, JA | 1 |
| Trudeau, JB | 1 |
| Wenzel, SE | 1 |
| Martin, RJ | 9 |
| van der Merwe, A | 1 |
| Allen, RH | 1 |
| Stabler, SP | 1 |
| Riezler, R | 1 |
| Mano, K | 3 |
| Kamada, AK | 3 |
| Mascali, JJ | 1 |
| Cvietusa, P | 1 |
| Negri, J | 1 |
| Borish, L | 3 |
| Gordon, BR | 1 |
| Jaffar, ZH | 1 |
| Gozzard, N | 1 |
| Herd, CM | 1 |
| Blake, SM | 1 |
| Holbrook, M | 1 |
| Hughes, B | 1 |
| Higgs, GA | 1 |
| Nakahara, Y | 3 |
| Murata, M | 5 |
| Suzuki, T | 3 |
| Ohtsu, F | 3 |
| Nagasawa, K | 3 |
| Pak, J | 1 |
| Crescioli, S | 4 |
| Dal Carobbo, A | 1 |
| Maestrelli, P | 1 |
| Boschetto, P | 4 |
| Santagada, T | 1 |
| Hurst, TS | 1 |
| Parise, G | 1 |
| Fabbri, LM | 5 |
| Lawrence, M | 1 |
| Tomasko, M | 1 |
| Baker, KA | 1 |
| Kellerman, DJ | 1 |
| Richardt, D | 1 |
| Driver, HS | 1 |
| Buelga, DS | 1 |
| Vázquez, MA | 1 |
| Craig, T | 1 |
| Richerson, HB | 1 |
| Moeckli, J | 1 |
| Bielory, L | 1 |
| Tsunekawa, Y | 1 |
| Nadai, M | 4 |
| Yamaki, K | 6 |
| Nabeshima, T | 1 |
| Lilley, LL | 1 |
| Guanci, R | 1 |
| McNeill, ME | 2 |
| Graham, NB | 2 |
| Shono, S | 1 |
| Higa, K | 1 |
| Watanabe, R | 1 |
| Dan, K | 1 |
| Testi, R | 1 |
| MacLeod, D | 1 |
| Baum, WF | 1 |
| Klöditz, E | 1 |
| Schneyer, U | 1 |
| Alvarez Sintes, R | 2 |
| Alvarez Castro, MR | 1 |
| Merigian, K | 1 |
| Blaho, K | 1 |
| Carter, ER | 1 |
| Tomaç, N | 1 |
| Tuncer, A | 1 |
| Saraçlar, Y | 1 |
| Adalioğlu, G | 1 |
| Tamura, G | 2 |
| Sasaki, T | 1 |
| Nishimura, K | 1 |
| Iwasaki, E | 3 |
| Baba, M | 5 |
| Iwata, T | 4 |
| Okada, T | 1 |
| Ishikawa, A | 1 |
| Toyoshima, K | 2 |
| Doi, S | 2 |
| Murayama, N | 1 |
| McDonald, CJ | 2 |
| Pohl, WR | 1 |
| Kummer, F | 2 |
| Lorber, H | 1 |
| Würtz, J | 1 |
| Aigner, K | 1 |
| Pfeiffer, KP | 1 |
| Suissa, S | 4 |
| Hemmelgarn, B | 1 |
| Blais, L | 2 |
| Ernst, P | 3 |
| Zachary, CY | 1 |
| Vendrell, M | 1 |
| Muñoz, X | 1 |
| Pou, L | 1 |
| Anguera, A | 1 |
| Mayordomo, C | 1 |
| Maeda, Y | 1 |
| Omoda, K | 1 |
| Takeda, Y | 1 |
| Fukuhara, S | 1 |
| Fukuzawa, M | 1 |
| Ohune, T | 1 |
| Tsuya, T | 1 |
| Tsukiai, S | 1 |
| Selby, C | 1 |
| Engleman, HM | 1 |
| Fitzpatrick, MF | 1 |
| Sime, PM | 1 |
| Mackay, TW | 1 |
| Douglas, NJ | 3 |
| Barnett, PL | 1 |
| Caputo, GL | 1 |
| Baskin, M | 1 |
| Kuppermann, N | 1 |
| Lucena, MI | 1 |
| Almagro, J | 1 |
| Andrade, RJ | 1 |
| Hidalgo Sanchez, R | 1 |
| Sanchez de la Cuesta, F | 1 |
| Arakawa, H | 3 |
| Iklé, DN | 2 |
| Friday, GA | 1 |
| Khine, H | 1 |
| Lin, MS | 1 |
| Caliguiri, LA | 1 |
| Donahue, JG | 1 |
| Livingston, JM | 1 |
| Goetsch, MA | 1 |
| Greineder, DK | 1 |
| Platt, R | 1 |
| Kagoshima, M | 2 |
| Tomomatsu, N | 2 |
| Iwahisa, Y | 2 |
| Yamaguchi, S | 3 |
| Kawakami, Y | 2 |
| Terasawa, M | 2 |
| Butt, U | 1 |
| Criee, CP | 1 |
| Leupold, W | 2 |
| Loos, U | 1 |
| Podszus, T | 1 |
| Rabe, K | 1 |
| Rühle, KH | 3 |
| Sill, V | 1 |
| Schlimmer, P | 2 |
| Schmidt, M | 2 |
| Schmitz, M | 1 |
| Liebke, C | 1 |
| Niggemann, B | 2 |
| Wahn, U | 1 |
| Milanese, M | 1 |
| Crimi, E | 1 |
| Rehder, K | 1 |
| Brusasco, V | 1 |
| Edwardes, MD | 1 |
| Goodman, DC | 1 |
| Littenberg, B | 1 |
| O'Connor, GT | 1 |
| Brooks, JG | 1 |
| Matsuura, M | 1 |
| Schaarschmidt, S | 1 |
| Standl, T | 1 |
| Kleerup, EC | 1 |
| Bode, FR | 1 |
| Margo, K | 1 |
| Shaughnessy, AF | 1 |
| Pollard, SJ | 2 |
| Yancey, SW | 2 |
| Cox, FM | 1 |
| Emmett, A | 1 |
| Kato, M | 4 |
| Takei, K | 1 |
| Koper, I | 1 |
| Braun, H | 1 |
| Leutz, M | 1 |
| Burki, NK | 1 |
| Horie, S | 1 |
| Momose, T | 1 |
| Suzuki, J | 1 |
| Isobe, M | 1 |
| Shor, OA | 1 |
| Gafurov, MS | 1 |
| Meier, CR | 1 |
| Jick, H | 1 |
| Emerton, D | 1 |
| Martusewicz, M | 1 |
| Grubek-Jaworska, H | 3 |
| Zeidman, A | 1 |
| Gardyn, J | 1 |
| Fradin, Z | 1 |
| Fink, G | 2 |
| Mittelman, M | 2 |
| el Desoky, E | 1 |
| Ghazal, MH | 1 |
| Mohamed, MA | 1 |
| Klotz, U | 1 |
| Ohrui, T | 1 |
| Funayama, T | 1 |
| Sekizawa, K | 2 |
| Sasaki, H | 4 |
| Faust, D | 1 |
| Evans, DJ | 1 |
| Taylor, DA | 1 |
| Zetterstrom, O | 1 |
| O'Connor, BJ | 4 |
| Homer, CJ | 1 |
| Kazuma, N | 2 |
| Otsuka, K | 2 |
| Matsuoka, I | 2 |
| Peters, JI | 1 |
| Toda, K | 1 |
| Goriki, K | 1 |
| Ochiai, M | 1 |
| Tokunou, H | 1 |
| Uehara, S | 1 |
| Takahashi, H | 2 |
| Okusaki, K | 1 |
| Liu, Y | 1 |
| Asmus, MJ | 1 |
| Milavetz, G | 4 |
| Marshik, P | 1 |
| Teresi, ME | 1 |
| Makolkin, VI | 1 |
| Ovcharenko, SI | 1 |
| Sheianov, MV | 1 |
| Fujimura, M | 1 |
| Kamio, Y | 1 |
| Myou, S | 1 |
| Hashimoto, T | 3 |
| Matsuda, T | 1 |
| Kodama, H | 1 |
| Yoshida, I | 1 |
| Ishikawa, S | 1 |
| Ohtaki, A | 1 |
| Takahashi, T | 1 |
| Satoh, Y | 1 |
| Kawashima, O | 1 |
| Morishita, Y | 1 |
| Nakahara, H | 2 |
| Kubo, H | 2 |
| Muraki, M | 1 |
| Fukuoka, M | 3 |
| Schwartz, HJ | 2 |
| Petty, T | 1 |
| Dubé, LM | 1 |
| Swanson, LJ | 1 |
| Lancaster, JF | 1 |
| Li, JT | 3 |
| Pierzchała, W | 1 |
| Farnik-Brodzińska, M | 1 |
| Boros, MM | 1 |
| Chazan-Polanowska, E | 1 |
| Butz, AM | 2 |
| Huss, K | 1 |
| Thompson, L | 1 |
| Kolodner, K | 1 |
| Rand, CS | 1 |
| Bonazza, L | 1 |
| Nacci, P | 1 |
| Talamini, G | 1 |
| Chorostowska-Wynimko, J | 2 |
| Harnest, U | 2 |
| Sakalauskas, R | 2 |
| Magyar, P | 2 |
| Vetter, N | 2 |
| Steffen, H | 2 |
| Leichtl, S | 3 |
| Rathgeb, F | 3 |
| Moritani, C | 1 |
| Ishioka, S | 1 |
| Kambe, M | 1 |
| Powell, CV | 1 |
| Everard, ML | 1 |
| Juárez-Olguín, H | 1 |
| Flores-Pérez, J | 1 |
| Lares-Asseff, I | 1 |
| Vassallo, R | 1 |
| Lipsky, JJ | 1 |
| Neuhäuser, M | 1 |
| Hummel, T | 1 |
| Bennett, JA | 1 |
| Thompson Coon, J | 1 |
| Wilding, PJ | 1 |
| Nuhoğlu, Y | 1 |
| Barlan, IB | 1 |
| Başaran, MM | 1 |
| Davies, B | 1 |
| Brooks, G | 1 |
| Devoy, M | 1 |
| Shimizu, Y | 3 |
| Shichijo, M | 1 |
| Hiramatsu, K | 2 |
| Takeuchi, M | 2 |
| Nagai, H | 1 |
| Furukawa, CC | 1 |
| Rogers, DF | 1 |
| Giembycz, MA | 1 |
| Rogala, B | 1 |
| Nutini, S | 1 |
| Martini, T | 1 |
| Righi, R | 1 |
| Witschital, K | 1 |
| Fuchs, WS | 1 |
| Heese, U | 1 |
| von Nieciecki, A | 1 |
| Laicher, A | 1 |
| Bodner, A | 1 |
| Hens, C | 1 |
| Moser, C | 1 |
| Oster, H | 1 |
| Sansone, GR | 1 |
| Matin, A | 1 |
| Wang, SF | 1 |
| Bouboulis, D | 1 |
| Frieri, M | 1 |
| Cotter, T | 1 |
| Kilfeather, S | 1 |
| Ohkawa, K | 2 |
| Entzian, P | 1 |
| Bitter-Suermann, S | 1 |
| Burdon, D | 1 |
| Ernst, M | 1 |
| Schlaak, M | 1 |
| Zabel, P | 1 |
| Reijonen, TM | 1 |
| Cheung, D | 1 |
| Wever, AM | 1 |
| de GOEIJ, JA | 1 |
| de GRAAFF, CS | 1 |
| Steen, H | 1 |
| Sterk, PJ | 1 |
| Lanes, SF | 1 |
| Lanza, LL | 1 |
| Wentworth, CE | 1 |
| Chiappara, G | 1 |
| Vignola, AM | 1 |
| Gagliardo, R | 1 |
| Altieri, E | 1 |
| Térouanne, B | 1 |
| Vic, P | 1 |
| Bousquet, J | 3 |
| Landells, LJ | 4 |
| Coward, WR | 1 |
| Church, MK | 2 |
| Minoguchi, K | 2 |
| Kohno, Y | 1 |
| Oda, N | 1 |
| Wada, K | 1 |
| Miyamoto, M | 1 |
| Yokoe, T | 1 |
| Akabane, T | 1 |
| Mita, S | 2 |
| Jarjour, NN | 1 |
| Lacouture, PG | 1 |
| Spoelstra, FM | 1 |
| Berends, C | 1 |
| Dijkhuizen, B | 1 |
| de Monchy, JG | 1 |
| Kauffman, HF | 1 |
| Grutters, JC | 1 |
| Drent, M | 1 |
| van Velzen-Blad, H | 1 |
| van den Bosch, JM | 1 |
| Kokubu, F | 1 |
| Suzuki, H | 2 |
| Yasuhara, H | 1 |
| Crago, S | 1 |
| Coors, L | 1 |
| Lapidus, JA | 1 |
| Sapien, R | 1 |
| Murphy, SJ | 1 |
| Ohta, M | 1 |
| Yamamoto, T | 1 |
| Markham, A | 1 |
| Faulds, D | 1 |
| Tateishi, T | 2 |
| Asoh, M | 1 |
| Yamaguchi, A | 2 |
| Yoda, T | 1 |
| Okano, YJ | 1 |
| Koitabashi, Y | 2 |
| Kobayashi, S | 3 |
| Miyoshi, M | 1 |
| Sakurai, T | 1 |
| Kodama, S | 1 |
| Krieger, AC | 1 |
| Takeyasu, M | 1 |
| Abraham, WM | 1 |
| Sabater, JR | 1 |
| Szelenyi, S | 1 |
| Bähre, M | 1 |
| Watanabe, S | 1 |
| Yasuno, N | 1 |
| Arakawa, Y | 2 |
| Uzu, S | 1 |
| Kanda, S | 1 |
| Komoda, F | 2 |
| Hayakawa, H | 3 |
| Hayakawa, T | 2 |
| Devarajan, PV | 1 |
| Sule, PN | 1 |
| Parmar, DV | 1 |
| Boivin, JF | 1 |
| Horiguchi, T | 1 |
| Tachikawa, S | 1 |
| Kasahara, J | 1 |
| Doi, M | 1 |
| Shiga, M | 2 |
| Miyazaki, J | 1 |
| Sasaki, Y | 3 |
| Imazu, M | 1 |
| Löwhagen, O | 1 |
| Ekström, L | 1 |
| Holmberg, S | 1 |
| Wennerblom, B | 1 |
| Rosenfeldt, M | 1 |
| Redden, RJ | 1 |
| Hannon, JP | 1 |
| Li, S | 1 |
| Chen, Y | 1 |
| Tan, P | 1 |
| Cao, W | 1 |
| Zhuo, HT | 1 |
| Ling, SS | 1 |
| Wiegand, L | 1 |
| Mende, CN | 1 |
| Zaidel, G | 1 |
| Zwillich, CW | 2 |
| Petrocella, VJ | 1 |
| Rickard, KA | 1 |
| Fukao, T | 1 |
| Hirayama, K | 1 |
| Sakamoto, T | 1 |
| Torii, S | 1 |
| Bekman, NI | 1 |
| Tarasova, ON | 2 |
| Danilova, NP | 2 |
| Vasilov, RG | 2 |
| van den Berg, BT | 1 |
| Derks, MG | 1 |
| Koolen, MG | 1 |
| Braat, MC | 1 |
| Butter, JJ | 1 |
| van Boxtel, CJ | 1 |
| Verberne, AA | 1 |
| Ushida, M | 1 |
| Hiraba, K | 1 |
| Endo, S | 1 |
| Furukawa, S | 1 |
| Saito, Y | 1 |
| Oner, P | 1 |
| Gürdöl, F | 1 |
| Oner-Iyidon, Y | 1 |
| Kolanci, C | 1 |
| Büyüköztürk, S | 1 |
| Koshino, T | 1 |
| Kraus-Filarska, M | 1 |
| Zak-Nejmark, T | 1 |
| Małolepszy, J | 1 |
| Barg, W | 1 |
| Filarski, J | 1 |
| Crocetti, JG | 1 |
| Arakawa, M | 1 |
| Takamizawa, M | 1 |
| Sheikh, S | 1 |
| Goldsmith, LJ | 1 |
| Howell, L | 1 |
| Eid, N | 1 |
| Neville, RG | 3 |
| Pearson, MG | 1 |
| Richards, N | 1 |
| Patience, J | 1 |
| Sondhi, S | 1 |
| Wagstaff, B | 1 |
| Wells, N | 1 |
| Kemp, J | 1 |
| Tanikawa, K | 1 |
| Matsumoto, Y | 1 |
| Matsuzaki, T | 1 |
| Matsumoto, M | 1 |
| Noguchi, S | 1 |
| Goshima, T | 1 |
| Choy, DK | 1 |
| Ko, F | 1 |
| Li, ST | 1 |
| lp, LS | 1 |
| Leung, R | 1 |
| Hui, D | 1 |
| Lai, KN | 1 |
| Gluckman, TJ | 1 |
| Corbridge, T | 1 |
| Kirillov, MM | 1 |
| Shapovalova, TG | 1 |
| Riabova, AIu | 1 |
| Smoliak, SB | 1 |
| Bochkareva, LE | 1 |
| Kurnosova, OF | 1 |
| Kazban, OG | 1 |
| Flores-Murrieta, FJ | 1 |
| Mercado, DE | 1 |
| Rodríguez-Silverio, J | 1 |
| Chapela, R | 1 |
| Trakultivakorn, M | 1 |
| Tontayapiwat, A | 1 |
| Jiraporncharoen, K | 1 |
| Iwanaga, T | 1 |
| Takata, S | 1 |
| Takahashi, N | 1 |
| Hara, N | 1 |
| Hidi, R | 1 |
| Timmermans, S | 1 |
| Liu, E | 1 |
| Kume, H | 2 |
| Yoshida, N | 2 |
| Mizutani, H | 1 |
| Suzuki, R | 4 |
| Okano, Y | 1 |
| Matuda, T | 1 |
| Akimoto, Y | 1 |
| Miyoshi, T | 1 |
| Jensen, MW | 1 |
| Orr, LM | 1 |
| Iwano, J | 1 |
| Izumida, T | 1 |
| Takiguchi, Y | 1 |
| Minakuchi, K | 1 |
| Helms, PJ | 1 |
| Guereño, MT | 1 |
| Fornari, MC | 1 |
| Livio, DL | 1 |
| Diez, RA | 1 |
| Hernández, M | 1 |
| Salmen, S | 1 |
| Berrueta, L | 1 |
| Navas, M | 1 |
| Sánchez, B | 1 |
| Muñoz, J | 1 |
| Delgado, R | 1 |
| Romano, E | 1 |
| Rangel, A | 1 |
| Kips, JC | 1 |
| Peleman, RA | 1 |
| Miura, T | 1 |
| Kimura, K | 1 |
| Kosmas, EN | 1 |
| Michaelides, SA | 1 |
| Polychronaki, A | 1 |
| Roussou, T | 1 |
| Toukmatzi, S | 1 |
| Polychronopoulos, V | 1 |
| Baxevanis, CN | 1 |
| Gilbert-Barness, E | 1 |
| Drut, RM | 1 |
| Hartert, TV | 1 |
| Togias, A | 1 |
| Mellen, BG | 1 |
| Mitchel, EF | 1 |
| Snowden, MS | 1 |
| Griffin, MR | 1 |
| Milano, M | 1 |
| Danckwerts, MP | 1 |
| Falcão, AC | 1 |
| Rocha, MJ | 1 |
| Almeida, AM | 1 |
| Caramona, MM | 1 |
| Dal Piaz, V | 1 |
| Giovannoni, MP | 1 |
| Lalloo, UG | 1 |
| Bateman, ED | 1 |
| Feldman, C | 1 |
| Bardin, PG | 1 |
| Plit, M | 1 |
| Irusen, EM | 1 |
| O'Brien, J | 1 |
| Silverman, R | 1 |
| Suyama, H | 2 |
| Sako, T | 2 |
| Miyakawa, M | 1 |
| Shirase, E | 1 |
| Seto, T | 1 |
| Inada, H | 1 |
| Kobayashi, N | 2 |
| Tada, H | 1 |
| Furukawa, K | 1 |
| Hayashi, K | 1 |
| Hattori, H | 2 |
| Matsuoka, O | 1 |
| Isshiki, G | 1 |
| Tsukagoshi, H | 1 |
| Iwamae, S | 1 |
| Hisada, T | 1 |
| Ishizuka, T | 1 |
| Iizuka, K | 1 |
| Dobashi, K | 1 |
| Mori, M | 1 |
| Benayoun, S | 1 |
| Baltzan, M | 1 |
| Cai, B | 1 |
| Bettiol, J | 1 |
| Cataldo, D | 1 |
| Sele, J | 1 |
| Henquet, M | 1 |
| Kojima, J | 1 |
| Katoh, H | 1 |
| Taniguchi, T | 1 |
| Kawai, H | 1 |
| Fukui, H | 1 |
| Ohnishi, A | 2 |
| Onodera, K | 1 |
| Yoshimine, F | 1 |
| Sasagawa, M | 1 |
| Kon, Y | 1 |
| Suzuki, E | 1 |
| Gejyo, F | 1 |
| Mazurek, J | 1 |
| Lim, S | 4 |
| Jatakanon, A | 2 |
| Gordon, D | 1 |
| Macdonald, C | 1 |
| Souness, JE | 1 |
| Borrás-Blasco, J | 1 |
| Rosique-Robles, JD | 1 |
| Peris-Martí, J | 1 |
| Santos-Calle, FJ | 1 |
| Navarro-Ruiz, A | 1 |
| Gonzalez-Delgado, M | 1 |
| Kawai, M | 1 |
| Willak-Janc, E | 1 |
| Sherman, J | 1 |
| Tan, KS | 1 |
| Cogo, R | 1 |
| Sakakibara, H | 1 |
| Berg, MJ | 1 |
| Holimon, TD | 1 |
| Chafin, CC | 1 |
| Ono, Y | 1 |
| Tanigaki, T | 1 |
| Syouyama, Y | 1 |
| Moue, Y | 1 |
| Kamiya, U | 1 |
| Tazaki, G | 1 |
| Ohta, Y | 1 |
| Chavis, C | 1 |
| Majori, M | 1 |
| Farce, M | 1 |
| Chassany, O | 1 |
| Segrestaa, JM | 1 |
| Tatsuta, H | 1 |
| Sakamoto, K | 1 |
| Morita, H | 1 |
| Tsukadaira, A | 1 |
| Takashi, S | 1 |
| Kubo, K | 1 |
| Koyama, S | 1 |
| Szilagy, CM | 1 |
| Jones, NA | 1 |
| Allen, JM | 1 |
| Doherty, A | 1 |
| Oliver, B | 2 |
| Carramori, G | 1 |
| Hatchaleelaha, S | 1 |
| Jintavorn, V | 1 |
| Kerdsomnuig, S | 1 |
| Yu, B | 1 |
| He, Q | 1 |
| Gao, Z | 1 |
| Parameswaran, K | 1 |
| Vielhaber, MM | 1 |
| Kavuru, M | 1 |
| Feoktistov, I | 1 |
| Biaggioni, I | 1 |
| Yoshida, S | 1 |
| Tomioka, H | 1 |
| Kagami, M | 1 |
| Nakazawa, T | 1 |
| Eliasson, M | 1 |
| Sandström, T | 1 |
| Boman, G | 4 |
| Mayo, PR | 1 |
| Hojo, M | 1 |
| Kudo, K | 1 |
| Rojanasthien, N | 1 |
| Kovjiriyapan, K | 1 |
| Manorot, M | 1 |
| Pothirat, C | 1 |
| He, JQ | 1 |
| Joos, L | 1 |
| Sandford, AJ | 1 |
| Kitaichi, K | 1 |
| Shibata, E | 1 |
| Tu, HY | 1 |
| Li, QQ | 1 |
| Sakakibara, A | 1 |
| Niwa, S | 1 |
| Koishikawa, I | 1 |
| Kobayashi, T | 1 |
| Morali, T | 1 |
| Yilmaz, A | 1 |
| Erkan, F | 1 |
| Akkaya, E | 1 |
| Ece, F | 1 |
| Baran, R | 1 |
| Miyata, M | 1 |
| Mo, H | 1 |
| Huang, H | 1 |
| Ebihara, S | 1 |
| Ebihara, T | 1 |
| Kanda, A | 1 |
| Nevzorova, VA | 1 |
| Suvorenko, TN | 1 |
| Konovalova, EN | 1 |
| Lin, CC | 2 |
| Lin, CY | 1 |
| Liaw, SF | 1 |
| Chen, A | 1 |
| Koczorek, M | 1 |
| Nie, HX | 1 |
| Hu, SP | 1 |
| Wu, XJ | 1 |
| Terao, I | 1 |
| Cosio, B | 1 |
| Kessler, GF | 1 |
| Fossati, C | 1 |
| Hofmann, D | 1 |
| Lecks, HI | 1 |
| Landau, LI | 1 |
| Dry, J | 2 |
| Pradalier, A | 1 |
| Leynadier, F | 1 |
| Sherman, BV | 1 |
| Walters, JK | 1 |
| Cato, AE | 1 |
| Harris, JR | 1 |
| Simonsson, BG | 1 |
| Frank, A | 1 |
| Frewin, DB | 1 |
| Lindsay, D | 1 |
| O'Loughlin, JM | 2 |
| Scoggin, CH | 1 |
| Anderson, S | 1 |
| Ferris, L | 1 |
| Schoeffel, R | 1 |
| Lindsay, DA | 2 |
| Labrune, B | 1 |
| Badoual, J | 1 |
| Hambleton, G | 1 |
| Taylor, J | 1 |
| Cavanaugh, M | 1 |
| Ginchansky, E | 3 |
| Tooley, M | 2 |
| Bell, T | 3 |
| Greenberg, S | 1 |
| Gribbin, HR | 1 |
| Lauer, BA | 1 |
| Merkus, FW | 1 |
| Incaudo, GI | 1 |
| Kahler, S | 1 |
| Hamburger, RN | 1 |
| Nyhan, WL | 1 |
| Bone, RC | 1 |
| Hiller, C | 1 |
| Chodosh, S | 4 |
| Morgan, EJ | 1 |
| Schulaner, FA | 1 |
| Mattikow, MS | 1 |
| Marks, MB | 3 |
| Abarzua, J | 1 |
| Branan, WJ | 1 |
| Wray, BB | 1 |
| Green, C | 1 |
| Yaffe, SJ | 2 |
| Benatar, SR | 1 |
| Coffey, RG | 1 |
| Palmer, KN | 2 |
| Kaik, G | 2 |
| Bonelli, J | 2 |
| Hitzenberger, G | 2 |
| Laggner, A | 2 |
| Magometschnigg, D | 2 |
| Katsampes, CF | 1 |
| Wilson, WM | 1 |
| Germouty, J | 4 |
| Bonnaud, F | 3 |
| Gay, G | 1 |
| Raij K-Alanko, K | 1 |
| Härkönen, M | 1 |
| Ikemori, K | 1 |
| Kashima, T | 1 |
| Kalisker, A | 4 |
| Nelson, HE | 1 |
| Weisberg, SC | 2 |
| Bush, RK | 4 |
| Smith, AM | 1 |
| Welling, PG | 2 |
| Alcala, JC | 1 |
| Lee, TP | 1 |
| Reinert, M | 1 |
| Biro, G | 1 |
| Giesen, HK | 2 |
| Fryda-Kaurimsky, Z | 1 |
| Asakura, K | 1 |
| Kataura, A | 1 |
| Wieczorek, RR | 1 |
| Horner-Rosner, B | 1 |
| Rhomberg, F | 1 |
| Melvin, GR | 1 |
| Aceto, T | 1 |
| Barlow, J | 1 |
| Munson, D | 1 |
| Wierda, D | 1 |
| Walker, J | 2 |
| Safirstein, BH | 1 |
| Dhakhwa, RB | 1 |
| Gelb, B | 1 |
| Fontunato, FD | 1 |
| Lang, P | 1 |
| Goel, Z | 1 |
| Grieco, MH | 2 |
| Avner, SE | 1 |
| Meyer, GE | 1 |
| Jeffrey, LP | 1 |
| Boyd, GK | 1 |
| Mahoney, CD | 1 |
| Johnson, PN | 1 |
| Groncy, CE | 1 |
| Duriseti, S | 1 |
| Strick, L | 4 |
| Sims, JA | 2 |
| doPico, GA | 1 |
| Stenius, B | 1 |
| Poppius, H | 2 |
| Lahdensuo, A | 4 |
| Baigelman, W | 1 |
| Sheen, AE | 1 |
| Hite, S | 1 |
| Giblin, VR | 1 |
| Hebert, M | 1 |
| Thiruvengadam, KV | 2 |
| Haranath, K | 1 |
| Sudarsan, S | 1 |
| Sekar, TS | 1 |
| Rajagopal, KR | 1 |
| Zacharian, MG | 1 |
| Devarajan, TV | 1 |
| Joos, E | 1 |
| Seebach, A | 1 |
| Jones, RW | 1 |
| Voss, H | 1 |
| Alexander, AB | 1 |
| Cropp, GJ | 1 |
| McCombs, RP | 1 |
| Lowell, FC | 1 |
| Ohman, JL | 1 |
| Mattila, MJ | 4 |
| Fleetham, JA | 1 |
| Owen, JA | 1 |
| May, B | 1 |
| Munt, PW | 1 |
| Nakatsu, K | 1 |
| Hanna, CJ | 1 |
| Eyre, P | 1 |
| Edmunds, AT | 2 |
| McKenzie, S | 5 |
| Baillie, E | 5 |
| Brandon, BM | 1 |
| Stolley, PD | 1 |
| West, SK | 1 |
| Swartz, D | 1 |
| Rumrill, R | 1 |
| Ahmad, M | 1 |
| Lindquist, C | 1 |
| Webb-Johnson, DC | 1 |
| Andrews, JL | 1 |
| Feldman, NT | 1 |
| Pollock, J | 1 |
| Kiechel, F | 1 |
| Cooper, D | 2 |
| Hobday, JD | 1 |
| Briggs, CJ | 1 |
| Lo, L | 1 |
| Christie, DL | 1 |
| Holmen, TL | 1 |
| Van Dellen, RG | 2 |
| Arwood, LL | 1 |
| Dasta, JF | 1 |
| Friedman, C | 1 |
| Bruns, WT | 1 |
| Gallen, WJ | 1 |
| Sublett, JL | 1 |
| Kohn, BA | 1 |
| Geha, RS | 1 |
| Umstead, GS | 1 |
| Menillet, G | 2 |
| Santais, MC | 2 |
| Edlund, PO | 1 |
| Winbladh, B | 1 |
| Kozak, PP | 2 |
| Pihlajamäki, K | 2 |
| Harris, MR | 1 |
| Klumpp, JA | 1 |
| Rutland, J | 1 |
| Talseth, T | 2 |
| Boye, NP | 2 |
| Prime, FJ | 1 |
| Bianco, S | 1 |
| Buchanan, N | 2 |
| Hurwitz, S | 1 |
| Butler, P | 1 |
| Naish, PJ | 1 |
| Cooke, M | 1 |
| Chambers, RE | 1 |
| Domson, JF | 2 |
| Buffone, GJ | 1 |
| Rangsithienchai, P | 1 |
| Newcomb, RW | 1 |
| Vanderpool, G | 1 |
| Miller, KW | 1 |
| Strem, EL | 1 |
| Austrian, S | 1 |
| Johnson, PB | 1 |
| Levy, G | 3 |
| Gibson, TP | 1 |
| Whitman, W | 1 |
| Procknal, J | 1 |
| Kordash, TR | 1 |
| McCall, JT | 1 |
| Anagnostopoulos, C | 1 |
| Komarek, J | 1 |
| van Gennip, AH | 1 |
| Grift, J | 1 |
| van Bree-Blom, EJ | 1 |
| Ketting, D | 1 |
| Wadman, SK | 1 |
| Dorsett, CS | 1 |
| Gibiński, K | 1 |
| Giec, L | 1 |
| Gamski, M | 1 |
| Gorzko, M | 1 |
| Swiatecka, M | 1 |
| Dosiak, J | 1 |
| Król, W | 1 |
| Zola-Sleczek, E | 1 |
| Pracka, H | 1 |
| Stasiński, T | 1 |
| Biryńczyk, J | 1 |
| Hempton, D | 1 |
| Wyatt, R | 2 |
| Steen, SN | 2 |
| Rosegger, H | 1 |
| Tourville, JF | 1 |
| Finer, MA | 1 |
| Haddad, ZH | 1 |
| Verma, S | 1 |
| Soderberg-Warner, M | 1 |
| Kalra, V | 1 |
| Meek, JH | 1 |
| Caplin, I | 1 |
| Haynes, JT | 1 |
| Brørs, O | 1 |
| Schindl, R | 3 |
| Budmiger, H | 1 |
| Bighley, L | 1 |
| Leung, PK | 1 |
| Cooley, RL | 1 |
| Buck, VM | 1 |
| Dugue, P | 1 |
| Cano, JP | 1 |
| Henry, JP | 1 |
| Vervloet, D | 2 |
| Pedersen, JT | 1 |
| Powell, JR | 1 |
| Vozeh, S | 2 |
| Hopewell, P | 1 |
| Sheiner, LB | 1 |
| Bigley, J | 1 |
| Leung, P | 2 |
| Ha, LT | 1 |
| Richards, D | 1 |
| Plavsić, F | 1 |
| Bakran, I | 1 |
| Vrhovac, B | 1 |
| Albrecht, H | 1 |
| Messerli, C | 1 |
| Kagan, G | 1 |
| Rose, R | 1 |
| Lyons, HA | 1 |
| Thomas, JS | 1 |
| Talamo, RC | 1 |
| Doraiswami, S | 1 |
| Flod, NE | 1 |
| Franz, ML | 2 |
| Levine, BE | 1 |
| Loren, M | 1 |
| Miklich, DR | 1 |
| Barwise, G | 1 |
| Rudolph, BM | 1 |
| Warren, SL | 1 |
| Galgóczy, G | 1 |
| Lode, H | 1 |
| Mándi, A | 1 |
| Stresemann, E | 1 |
| Floyd, RA | 1 |
| Cohen, JL | 1 |
| Wolff, ED | 1 |
| Driessen, OM | 1 |
| Brasher, GW | 1 |
| Gillman, SA | 1 |
| Cummins, LH | 1 |
| Orcutt, JJ | 1 |
| Mitchell, C | 1 |
| Bouhuys, A | 2 |
| Komarov, FI | 1 |
| Daniliak, IG | 2 |
| Jacob, SC | 1 |
| Hsu, KH | 1 |
| Baagoe, KH | 1 |
| Weinberger, MW | 1 |
| Ginchansky, EJ | 1 |
| Chidsey, CA | 1 |
| Petty, TL | 3 |
| Salem, H | 3 |
| Wood, DW | 1 |
| Lecks, HJ | 1 |
| Pickup, ME | 2 |
| May, CS | 2 |
| Ssendagire, R | 1 |
| Rasawieh, M | 1 |
| Shannon, DC | 1 |
| Gorodisher, R | 1 |
| Bories, H | 1 |
| Bensch, GW | 1 |
| Bock, GN | 1 |
| Yecies, JJ | 1 |
| Fitchett, DH | 1 |
| McNicol, MW | 1 |
| Riordan, JF | 1 |
| Rosenberg, TF | 1 |
| Medsger, TA | 1 |
| DeCicco, FA | 1 |
| Johnson, GF | 1 |
| Dechtiaruk, WA | 1 |
| Solomon, HM | 1 |
| Piafsky, KM | 1 |
| Koysooko, R | 3 |
| Antonsen, BJ | 1 |
| Badiei, B | 1 |
| Bülow, KB | 1 |
| Larsson, H | 1 |
| Leideman, T | 2 |
| Shapiro, L | 1 |
| Domoradzki, J | 1 |
| Paroli, M | 1 |
| Di Benedetto, G | 1 |
| Eney, RD | 1 |
| Goldstein, EO | 1 |
| Mutoh, T | 1 |
| Horie, T | 1 |
| Inafuku, M | 1 |
| Hariya, Y | 1 |
| Yoshioka, Y | 1 |
| Phillips, MS | 1 |
| Chyrek-Borowska, S | 1 |
| Siergiejko, Z | 1 |
| Michalska, I | 1 |
| Szymański, W | 1 |
| Ali, S | 2 |
| Mustafa, SJ | 3 |
| Metzger, WJ | 3 |
| Callaghan, B | 2 |
| Teo, NC | 1 |
| Clancy, L | 2 |
| Joseph, BZ | 1 |
| Sustiel, AM | 1 |
| Wang, S | 1 |
| De Marzo, N | 3 |
| Spinazzi, A | 2 |
| Plebani, M | 5 |
| Mapp, CE | 3 |
| Ciaccia, A | 1 |
| Handley, DA | 1 |
| DeLeo, JJ | 1 |
| Havill, AM | 1 |
| Midgren, B | 1 |
| Melander, B | 1 |
| Persson, G | 2 |
| Shibasaki, M | 1 |
| Takeda, K | 1 |
| Sumazaki, R | 1 |
| Nogami, T | 1 |
| Takita, H | 1 |
| Bons, J | 1 |
| Pappo, M | 2 |
| Georges, D | 2 |
| Grammer, LC | 1 |
| Adams, SL | 1 |
| Martin, HG | 1 |
| Fauroux, B | 1 |
| Just, J | 1 |
| Couvreur, J | 1 |
| Grimfeld, A | 1 |
| Janson, C | 2 |
| Kida, K | 1 |
| Busse, W | 1 |
| Komuta, K | 1 |
| Sinues, B | 1 |
| Broto, A | 1 |
| Suarez, MA | 1 |
| Duce, F | 1 |
| Martinez-Berganza, A | 1 |
| Bernal, ML | 1 |
| Blanchard, J | 3 |
| Harvey, S | 3 |
| Leung, DY | 1 |
| Gleason, MC | 1 |
| Hill, MR | 3 |
| Yamada, N | 1 |
| Kadowaki, S | 1 |
| Umezu, K | 1 |
| Stuart, AM | 1 |
| Worley, LM | 1 |
| Spillane, J | 1 |
| Chang, DB | 1 |
| Yang, PC | 1 |
| Shen, FH | 1 |
| Luh, KT | 1 |
| Gao, Y | 1 |
| Pons, G | 1 |
| Rey, E | 1 |
| d'Athis, P | 1 |
| Bertin, L | 2 |
| Thiroux, G | 1 |
| Olive, G | 1 |
| Mansfeld, J | 2 |
| Virchow, C | 3 |
| Glynn-Barnhart, AM | 1 |
| Erzurum, SC | 1 |
| Leff, JA | 1 |
| Cochran, JE | 1 |
| Cott, GR | 1 |
| Sergeev, PV | 1 |
| Omel'ianovskiĭ, VV | 1 |
| Dukhanin, AS | 1 |
| Bondareva, GP | 2 |
| Botha, JH | 1 |
| Tyrannes, I | 1 |
| Wesley, AG | 1 |
| Nicholson, JP | 1 |
| Basile, SA | 1 |
| Cury, JD | 1 |
| Philip-Joet, F | 2 |
| Bruguerolle, B | 3 |
| Reynaud, M | 1 |
| Arnaud, A | 3 |
| Soto, J | 1 |
| Sacristán, JA | 1 |
| Alsar, MJ | 1 |
| Lindgren, S | 2 |
| Lokshin, B | 1 |
| Stromquist, A | 1 |
| Nassif, E | 1 |
| Frasher, R | 1 |
| Rohdewald, P | 1 |
| Cicutto, LC | 3 |
| Ackerson, LM | 1 |
| Guss, S | 1 |
| Portnoy, J | 1 |
| Koenig, JQ | 1 |
| Dumler, K | 1 |
| Rebolledo, V | 1 |
| Williams, PV | 2 |
| Brenner, AM | 1 |
| Mossberg, B | 1 |
| Yagupsky, P | 1 |
| Shahak, E | 1 |
| Bearman, JE | 1 |
| Zuili, I | 1 |
| Shany, S | 1 |
| Vadász, I | 1 |
| Bauman, A | 2 |
| Mitchell, CA | 1 |
| Henry, RL | 1 |
| Robertson, CF | 1 |
| Comino, EJ | 1 |
| Hensley, MJ | 1 |
| Leeder, SR | 1 |
| Minotti, DA | 1 |
| Altman, LC | 1 |
| Ayars, GH | 1 |
| Popick, FR | 1 |
| Benn, VJ | 1 |
| Fleisher, GR | 2 |
| Surpure, JS | 1 |
| Rosenberg, NM | 1 |
| Kulick, R | 1 |
| Tirot, P | 1 |
| Bouachour, G | 1 |
| Varache, N | 1 |
| Harry, P | 1 |
| Bourrier, P | 1 |
| Chennebault, JM | 1 |
| Alquier, P | 1 |
| Lim, TO | 1 |
| Suppiah, A | 1 |
| Ismail, F | 1 |
| Selvan, T | 1 |
| Khan, NK | 1 |
| Ngah, BA | 1 |
| Eigen, HN | 1 |
| Shigeta, M | 3 |
| Tateno, K | 1 |
| Tang, RB | 1 |
| Wu, KG | 1 |
| Chao, T | 1 |
| Chang, YR | 1 |
| Hwang, B | 1 |
| Tabe, K | 1 |
| Houya, I | 1 |
| Kiuchi, H | 1 |
| Dohi, Y | 1 |
| Condino-Neto, A | 1 |
| Vilela, MM | 1 |
| Cambiucci, EC | 1 |
| Ribeiro, JD | 1 |
| Guglielmi, AA | 1 |
| Magna, LA | 1 |
| De Nucci, G | 1 |
| Sanathanan, LP | 1 |
| Peck, CC | 2 |
| Murphy, CM | 1 |
| Coonce, SL | 1 |
| Simon, PA | 1 |
| Rheinberg, A | 1 |
| Tse, M | 1 |
| Bridges-Webb, C | 1 |
| Arkinstall, WW | 4 |
| Miyai, K | 1 |
| Seki, T | 1 |
| Kawaguchi, Y | 1 |
| Ziganshin, AS | 1 |
| Kaganov, SIu | 1 |
| Court, M | 1 |
| Miller, AJ | 1 |
| Szefler, S | 3 |
| Ellis, E | 1 |
| Dowse, R | 1 |
| Futter, WT | 1 |
| Stern, M | 1 |
| Collins, JV | 1 |
| Evans, T | 1 |
| Brar, PS | 1 |
| Stewart, JH | 4 |
| Aoshima, M | 1 |
| Kameyama, S | 1 |
| Murai, Y | 1 |
| Kamiya, T | 1 |
| Miyazaki, T | 1 |
| Lerner, JA | 2 |
| Ikle, D | 1 |
| Comer, C | 1 |
| Suenaga, N | 1 |
| Nakamura, H | 1 |
| Kurusu, M | 1 |
| Nishioka, Y | 1 |
| Kitada, O | 1 |
| Sugita, M | 1 |
| Leakey, TE | 2 |
| Coates, PE | 1 |
| Smith, KJ | 1 |
| Brune, J | 1 |
| Desfougères, JL | 2 |
| Thomas, G | 1 |
| Koen, R | 1 |
| Houze, P | 1 |
| Lagier, G | 1 |
| Gervais, P | 3 |
| Cary, J | 1 |
| Hein, K | 1 |
| Dell, R | 1 |
| Kumar, A | 1 |
| Chakrabarti, A | 1 |
| Garg, SK | 3 |
| Didkovskiĭ, NA | 3 |
| Abazova, FI | 2 |
| Kablashova, NA | 1 |
| Kozhanov, AM | 2 |
| Kholodov, LE | 2 |
| Bondarenko, GP | 1 |
| Noreĭka, RM | 1 |
| Suskovic, S | 1 |
| Jurcic, B | 1 |
| Lenardic, A | 1 |
| Winsel, K | 1 |
| Förster, R | 4 |
| Hill, AR | 1 |
| Adimoolam, S | 1 |
| Shivaram, U | 1 |
| Cash, M | 1 |
| Sauter, R | 3 |
| Böhm, A | 3 |
| Dietrich, R | 1 |
| Benedikt, G | 1 |
| Feldman, S | 2 |
| Gianotti, LA | 2 |
| Emerson, MB | 2 |
| Staudinger, HW | 4 |
| Siebert, B | 4 |
| Borner, K | 3 |
| von Berg, A | 3 |
| Pokrajac, M | 2 |
| Agbaba, D | 2 |
| Miljkovic, B | 1 |
| Llupiá, J | 1 |
| Fernández, AG | 1 |
| Berga, P | 1 |
| Costa, R | 1 |
| Marino, A | 1 |
| Guglielmo, L | 1 |
| Leone, R | 1 |
| Conforti, A | 1 |
| Schauer, U | 1 |
| Dippel, E | 1 |
| Gieler, U | 1 |
| Bräuer, J | 1 |
| Jung, T | 1 |
| Heymanns, J | 1 |
| Wei, IW | 1 |
| Hoppel, CL | 1 |
| Eggleston, P | 2 |
| Alexander, C | 1 |
| Rosenstein, BJ | 1 |
| Foo, AL | 1 |
| Sly, PD | 1 |
| Yasunami, J | 1 |
| Hayashida, M | 1 |
| Inoue, T | 1 |
| Takamatsu, I | 1 |
| Kishimoto, S | 1 |
| Yilmaz, E | 1 |
| Canberk, A | 1 |
| Eroğlu, L | 1 |
| Kuzuya, T | 3 |
| Crombie, IK | 1 |
| Freeman, W | 1 |
| Packe, GE | 1 |
| Cayton, RM | 1 |
| Osterwalder, JJ | 1 |
| Knoblauch, A | 1 |
| Takemura, T | 1 |
| Kino, R | 1 |
| Day, RO | 1 |
| Pearce, GA | 1 |
| Fulde, GW | 1 |
| Avital, A | 2 |
| Steljes, DG | 1 |
| Pasterkamp, H | 1 |
| Kryger, M | 1 |
| Sanchez, I | 1 |
| Chernick, V | 1 |
| Franzone, JS | 2 |
| Reboani, MC | 2 |
| Biglione, V | 1 |
| Cirillo, R | 1 |
| Mintzer, MJ | 1 |
| Gellert, AR | 1 |
| Gellert, SL | 1 |
| Iliffe, SR | 1 |
| Fourrier, E | 1 |
| Schmitz-Schumann, H | 1 |
| Weinberg, H | 1 |
| Tsukioka, K | 1 |
| Nakamata, M | 1 |
| Kondo, A | 1 |
| Musk, AW | 1 |
| Jenkins, MA | 1 |
| Hurley, SF | 1 |
| McNeil, JJ | 1 |
| Halpern, GM | 1 |
| Ojeda Casas, JA | 1 |
| García Ara, MC | 1 |
| Martín Muñoz, F | 1 |
| Díaz Pena, JM | 1 |
| Añibarro Bausera, B | 1 |
| Escobar Castro, H | 1 |
| Zamir, C | 1 |
| Qivity, S | 1 |
| Heldenberg, D | 1 |
| Topilsky, M | 3 |
| Clauzel, AM | 1 |
| Rifai, N | 1 |
| Vergnaud, A | 1 |
| Bony, C | 1 |
| Marín, JM | 1 |
| Carrizo, S | 1 |
| García, R | 1 |
| Ejea, MV | 1 |
| Pesić, V | 1 |
| Hughes, DM | 1 |
| McLeod, M | 1 |
| Garner, B | 1 |
| Goldbloom, RB | 1 |
| Bai, TR | 2 |
| Miyatake, H | 1 |
| Taki, F | 1 |
| Schlieper, A | 1 |
| Alcock, D | 1 |
| Beaudry, P | 1 |
| Feldman, W | 1 |
| Leikin, L | 1 |
| Berlow, BA | 1 |
| Liebhaber, MI | 1 |
| Dyer, Z | 1 |
| Spiegel, TM | 1 |
| Pozzani, M | 1 |
| Goldenheim, PD | 5 |
| Schein, LK | 2 |
| Poe, RH | 1 |
| Utell, MJ | 1 |
| Corren, J | 1 |
| Glynn-Barnhart, A | 2 |
| Baldwin, DR | 1 |
| Berg, JD | 1 |
| Buckley, BM | 1 |
| Mackay, AD | 1 |
| Schachtel, BP | 1 |
| Chen, TM | 1 |
| Roseberry, HR | 1 |
| Thoden, WR | 1 |
| Driver, AG | 1 |
| Kukoly, CA | 1 |
| Manzanares, C | 1 |
| Ibañez, A | 1 |
| Dorado, CA | 1 |
| Sanz, R | 1 |
| Bittar, G | 1 |
| Friedman, HS | 1 |
| Dunn, DW | 1 |
| Parekh, HU | 1 |
| Praetorius, F | 1 |
| Korzh, OB | 3 |
| Vesco, D | 1 |
| Toumi, M | 2 |
| Faraj, F | 2 |
| Razzouk, H | 2 |
| Paditz, E | 1 |
| Gramatté, T | 1 |
| Richter, K | 1 |
| Feller, K | 1 |
| Aikawa, T | 1 |
| Yanai, M | 1 |
| Itabashi, S | 1 |
| Fukushima, T | 1 |
| Paty, E | 1 |
| Brunet, D | 1 |
| Le Bourgeois, M | 1 |
| Garcelon, M | 1 |
| Randolph, C | 1 |
| Newhouse, MT | 2 |
| Lam, A | 2 |
| Segawa, H | 2 |
| Lazzaroni, M | 1 |
| Grossi, E | 1 |
| Bianchi Porro, G | 1 |
| Amirav, I | 2 |
| Bidat, E | 2 |
| Leneveu, A | 2 |
| Aergerter, P | 1 |
| Roux, A | 2 |
| Flouvat, B | 2 |
| Gallet, JP | 2 |
| Schwarz, YA | 1 |
| Kivity, S | 2 |
| Ilfeld, DN | 4 |
| Schlesinger, M | 2 |
| Greif, J | 1 |
| Garty, MS | 1 |
| Otto, J | 1 |
| Günther, S | 1 |
| Soares, FJ | 1 |
| Solé, D | 2 |
| Naspitz, CK | 2 |
| MacCosbe, PE | 1 |
| Sykes, RS | 1 |
| Garcha, BS | 1 |
| Lutz, CN | 3 |
| Johnston, ID | 2 |
| Serfontein, WJ | 2 |
| Bartel, P | 1 |
| Staudinger, H | 2 |
| Mallin, W | 1 |
| Semmelrock, HJ | 1 |
| Gusel', VA | 1 |
| Zisel'son, AD | 1 |
| Smirnov, DP | 1 |
| Park, JM | 1 |
| Schmer, V | 1 |
| Myers, TL | 1 |
| Brander, PE | 1 |
| Sovijärvi, AR | 1 |
| Salmi, T | 1 |
| Hakulinen, A | 2 |
| Greenberger, PA | 2 |
| Frederiksen, MC | 2 |
| Brander, P | 1 |
| Laitinen, J | 1 |
| Aalto, E | 1 |
| Silvasti, M | 1 |
| Karttunen, P | 2 |
| Martins, AM | 1 |
| Macready, JJ | 1 |
| Hamilton, DP | 1 |
| Cherniwchan, DP | 1 |
| Kishida, M | 2 |
| Hukushima, K | 1 |
| Aelony, Y | 2 |
| Gavrilenko, LN | 5 |
| Kushkenbaeva, BE | 1 |
| Siegel, IA | 1 |
| Ben-Aryeh, H | 3 |
| Gozal, D | 3 |
| Colin, AA | 3 |
| Szargel, R | 2 |
| Laufer, D | 1 |
| Goldenheim, P | 1 |
| Eshleman, SH | 1 |
| Shaw, LM | 1 |
| Vilsvik, JS | 1 |
| Amundsen, T | 1 |
| Brenna, E | 1 |
| Naustdal, T | 1 |
| Syvertsen, U | 1 |
| Storstein, L | 1 |
| Källén, AG | 1 |
| Eriksson, G | 4 |
| Holte, S | 1 |
| Kelkel, E | 1 |
| Pison, C | 1 |
| Pin, I | 1 |
| Paramelle, B | 3 |
| Brambilla, C | 1 |
| Campbell, S | 1 |
| Hood, I | 1 |
| Ryan, D | 1 |
| Biedrzycki, L | 1 |
| Mirchandani, H | 1 |
| Vygovskiĭ, VP | 1 |
| Stadnicheko, RA | 1 |
| Borzhievskaia, OE | 1 |
| Kopel'man, EI | 1 |
| Kozak, KM | 1 |
| Senyk, RV | 1 |
| Vygovskiĭ, IaV | 1 |
| Neff, RK | 1 |
| Leviton, A | 1 |
| Kern, DG | 1 |
| Walther, H | 2 |
| Stefadu, EG | 1 |
| Gneushev, ET | 1 |
| Kniazev, RP | 1 |
| Trnavská, Z | 3 |
| Kawakatsu, K | 1 |
| Kino, T | 1 |
| Yasuba, H | 1 |
| Kawaguchi, H | 1 |
| Tsubata, R | 1 |
| Satake, N | 1 |
| Oshima, S | 1 |
| Apichartpichean, R | 2 |
| Muraoka, I | 1 |
| Capps, N | 1 |
| Watkins, K | 1 |
| Jordan, P | 1 |
| Sewell, GJ | 1 |
| Gai, R | 1 |
| Oliaro, A | 1 |
| Galietti, F | 1 |
| Giorgis, GE | 1 |
| Bruna, S | 1 |
| Ardizzi, A | 1 |
| Bianchi, M | 1 |
| Bernardi, W | 1 |
| Mobley, RC | 1 |
| Altman, RE | 2 |
| Duvall, RM | 1 |
| Meyer, A | 1 |
| Jacobsen, P | 1 |
| Schmitz-Schumann, M | 3 |
| Bonnacker, I | 1 |
| Süverkrüp, R | 1 |
| Buhr, W | 2 |
| Rizzo, A | 3 |
| Mirabella, A | 3 |
| Bonanno, A | 3 |
| Trigg, CJ | 1 |
| Davies, RJ | 1 |
| Zheltikova, OA | 1 |
| Chervinskaia, TA | 1 |
| Sokolov, AV | 1 |
| Susanna, V | 1 |
| Loffreda, A | 1 |
| Servodio, R | 1 |
| Filippelli, A | 1 |
| Santagata, A | 1 |
| Montanaro, C | 1 |
| Carapella, N | 1 |
| Olson, R | 1 |
| Karpink, MH | 1 |
| Shelanski, S | 1 |
| Atkins, PC | 1 |
| Zweiman, B | 1 |
| Aviram, M | 2 |
| Gorodischer, R | 2 |
| Chandler, MH | 1 |
| Clifton, GD | 1 |
| Louis, BA | 1 |
| Coons, SJ | 1 |
| Foster, TS | 1 |
| Phillips, BA | 1 |
| Bogovskiĭ, VP | 1 |
| Semenova, LG | 2 |
| Antonovskiĭ, IuA | 1 |
| Bastianon, V | 1 |
| Di Fazio, A | 1 |
| Colloridi, V | 1 |
| Marzano, MC | 1 |
| Ferrucci, A | 1 |
| Pucci, S | 1 |
| Bernardini, L | 1 |
| Coletta, F | 1 |
| Sorbara, N | 1 |
| Businco, L | 1 |
| Ballard, RD | 2 |
| Ikeda, H | 1 |
| Sato, S | 1 |
| Takahashi, K | 1 |
| Kubota, I | 1 |
| Yasui, S | 1 |
| Miyazawa, K | 1 |
| Escamilla, R | 1 |
| Miguères, J | 1 |
| Jover, A | 1 |
| Krempf, M | 1 |
| Massabuau, P | 1 |
| Bonhoure, JP | 1 |
| Conradson, TB | 1 |
| Eklundh, G | 1 |
| Olofsson, B | 1 |
| Pahlm, O | 1 |
| Chevari, S | 1 |
| Andrial, T | 1 |
| Khorvat, R | 1 |
| Tomioka, S | 1 |
| Kuroiwa, H | 1 |
| Akagi, K | 1 |
| Kohi, F | 1 |
| Trivedi, R | 1 |
| Hager, H | 1 |
| Pohlmann-Eden, B | 1 |
| Pelikan, Z | 1 |
| Pelikan-Filipek, M | 1 |
| Cockcroft, DW | 3 |
| Murdock, KY | 1 |
| Gore, BP | 1 |
| O'Byrne, PM | 2 |
| Manning, P | 1 |
| Marin, J | 1 |
| Chiner, E | 1 |
| Franco, J | 1 |
| Borras, R | 1 |
| Boner, AL | 5 |
| Schöni, MH | 1 |
| Robinson, S | 1 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Gandola, L | 1 |
| Aiolfi, S | 1 |
| Soccini, F | 1 |
| Patrini, G | 1 |
| Capellini, G | 1 |
| Scartabellati, A | 1 |
| Ghio, L | 1 |
| Mauri, F | 1 |
| Rigby, PJ | 2 |
| Goldie, RG | 3 |
| Boos, R | 1 |
| van Kampen, C | 1 |
| Weede, W | 1 |
| Beck, W | 1 |
| Horiuchi, T | 1 |
| Clarke, H | 1 |
| Kiviranta, K | 1 |
| Reuter, C | 1 |
| Harlow, B | 1 |
| Scott, J | 1 |
| Flatt, A | 1 |
| Kwong, T | 1 |
| Ball, M | 1 |
| Grassi, V | 2 |
| Boschetti, E | 1 |
| Tantucci, C | 1 |
| Epelbaum, S | 1 |
| Benhamou, PH | 1 |
| Pautard, JC | 1 |
| Devoldere, C | 1 |
| Kremp, O | 1 |
| Piussan, C | 1 |
| Horn, CR | 2 |
| Schwabl, D | 1 |
| Göpfrich, H | 1 |
| Iung, B | 2 |
| Laaban, JP | 3 |
| Rochemaure, J | 4 |
| Maria, Y | 1 |
| Moneret-Vautrin, DA | 1 |
| Taudorf, E | 1 |
| Gnosspelius, Y | 2 |
| Gymose, E | 1 |
| Miyake, T | 1 |
| Miwa, M | 1 |
| Noguchi, M | 2 |
| Nakashizuka, T | 1 |
| Tsuboi, E | 1 |
| Kodaka, T | 1 |
| Murakawa, K | 2 |
| Nakata, K | 2 |
| Eason, J | 1 |
| Markowe, HL | 1 |
| Pavesio, D | 1 |
| Mora, P | 2 |
| Leone, L | 2 |
| Moresco, V | 1 |
| Girardo, G | 1 |
| Barberio, G | 2 |
| Ruggeri, C | 2 |
| Pajno, GB | 2 |
| Morabito, L | 1 |
| Pollicino, A | 1 |
| Di Pasquale, F | 1 |
| Terranova, ML | 1 |
| Kumar, L | 1 |
| Lal, R | 1 |
| Shukla, VK | 1 |
| Dolezalová, K | 2 |
| Martínková, J | 2 |
| Kopecká, J | 2 |
| Kuralová, Z | 1 |
| Etlerová, E | 1 |
| Weiss, ME | 1 |
| Wheeler, B | 1 |
| Adkinson, NF | 1 |
| Neagley, SR | 1 |
| Cicutto, L | 1 |
| White, DP | 1 |
| Goldenhersh, MJ | 1 |
| Godfrey, KR | 1 |
| Stine, RJ | 2 |
| Marcus, RH | 2 |
| Parvin, CA | 2 |
| Chow, OK | 1 |
| Fung, KP | 1 |
| Ellis, RF | 1 |
| Amarshi, N | 1 |
| Rackham, A | 1 |
| Brown, CA | 1 |
| Chandra, RK | 1 |
| Ho, P | 1 |
| Hoogerwerf, PE | 1 |
| Kennedy, RJ | 1 |
| Knight, A | 1 |
| Langer, H | 1 |
| Milne, J | 1 |
| Moote, DW | 1 |
| Lammers, JW | 1 |
| McCusker, M | 1 |
| Roberts, NM | 1 |
| Nichol, GM | 1 |
| Creer, TL | 2 |
| Gustafson, KE | 1 |
| Baur, X | 1 |
| Evseev, NG | 2 |
| Treskunov, VG | 1 |
| Zakharzhevskaia, TV | 1 |
| Fil'ko, VN | 1 |
| Tatarskiĭ, AR | 1 |
| Barry, W | 1 |
| Loftus, BG | 2 |
| Price, JF | 3 |
| McWilliams, B | 1 |
| Vanto, T | 2 |
| Koivikko, A | 1 |
| Thuresson, SO | 1 |
| Jordan, TJ | 1 |
| Reichman, LB | 1 |
| Schnabel, D | 1 |
| Sweeney, GD | 1 |
| Kraan, J | 1 |
| Boorsma, M | 1 |
| van der Mark, TW | 1 |
| Slapke, J | 3 |
| Hummel, S | 3 |
| Wilke, A | 3 |
| Wenz, W | 3 |
| Nussbücker, B | 3 |
| Ayres, JG | 2 |
| Lew, G | 1 |
| Murray, WE | 1 |
| Lane, JR | 1 |
| Haeger, E | 1 |
| Christiaanse, ME | 1 |
| Lavigne, JV | 1 |
| Lerner, CV | 1 |
| Mansheim, P | 1 |
| Rodgers, A | 1 |
| Woodhouse, KW | 1 |
| Bateman, DN | 1 |
| Welsh, PW | 2 |
| O'Connell, EJ | 1 |
| Sachs, MI | 1 |
| Moyer, TP | 1 |
| Wick, KA | 1 |
| McCarville, SE | 2 |
| Kvam, DC | 1 |
| Samaan, S | 1 |
| Fox, R | 1 |
| Kabe, J | 2 |
| Horai, Y | 1 |
| Vondra, V | 2 |
| Spicák, V | 2 |
| Reisová, M | 1 |
| Pohunek, P | 1 |
| Tomíska, F | 1 |
| Harrist, RB | 2 |
| Hiatt, PW | 1 |
| Baenziger, JC | 2 |
| Klank, BJ | 2 |
| Gleeson, JG | 1 |
| Døssing, M | 1 |
| Evald, T | 1 |
| Lange, P | 1 |
| Christensen, HR | 1 |
| Schulte, T | 1 |
| Walkenbach, A | 1 |
| Brook, U | 1 |
| Singer, L | 1 |
| Fried, D | 1 |
| Matsumura, Y | 1 |
| Otsuka, H | 1 |
| Tomoe, Y | 1 |
| Sugiyama, H | 1 |
| Nakamura, T | 1 |
| Kolander, SA | 1 |
| Nydegger, CC | 1 |
| Porter, RS | 2 |
| Kossoy, AF | 1 |
| Hill, M | 5 |
| Lin, FL | 1 |
| Ayers, GJ | 1 |
| Baldwin, AJ | 1 |
| Fowler, AM | 1 |
| Goudie, JH | 1 |
| Burnett, D | 1 |
| Yiin, KT | 1 |
| Chiang, CD | 1 |
| Shih, WL | 1 |
| Huang, WL | 1 |
| Jih, KS | 1 |
| Lin, TM | 1 |
| Yang, GY | 1 |
| Mu, JY | 1 |
| Reddy, J | 1 |
| Kingston, ME | 1 |
| Duffy, C | 1 |
| Williams, J | 1 |
| Ram, B | 1 |
| Sizeland, PC | 1 |
| Martínez, MJ | 1 |
| Martínez, B | 1 |
| Saucedo, R | 1 |
| García Delgado, R | 1 |
| García Morillas, M | 1 |
| Puche, E | 1 |
| Birkhead, G | 1 |
| Attaway, NJ | 1 |
| Townsend, MC | 1 |
| Teutsch, S | 1 |
| Milner, A | 1 |
| Kinnear, G | 1 |
| Gorchakov, VD | 1 |
| Treskunov, VK | 1 |
| Hirota, N | 1 |
| Adachi, K | 1 |
| Yamawaki, H | 1 |
| Brady, HR | 1 |
| Ryan, F | 1 |
| Cunningham, J | 1 |
| Tormey, W | 1 |
| Ryan, MP | 1 |
| O'Neill, S | 1 |
| Stålenheim, G | 1 |
| Rooklin, A | 1 |
| Cohendy, R | 2 |
| De Souza, V | 1 |
| Menz, G | 1 |
| Hänsch, GM | 1 |
| Rother, U | 1 |
| Rother, K | 1 |
| DuHamel, TR | 2 |
| Furukawa, C | 1 |
| Mapp, C | 1 |
| dal Vecchio, L | 1 |
| Paleari, D | 2 |
| van Drost, RH | 1 |
| Fokkens, JK | 3 |
| Hamelink, MJ | 1 |
| Duhault, J | 1 |
| Boulanger, M | 1 |
| Lonchampt, M | 1 |
| Tisserand, F | 1 |
| Holstorp, S | 1 |
| Saint-Romas, G | 1 |
| Pennel, L | 1 |
| Regnier, G | 1 |
| Robertson, C | 2 |
| James, AL | 1 |
| Phillips, MJ | 1 |
| Verini, M | 1 |
| Ansaloni, A | 1 |
| Di Vincenzo, MG | 1 |
| Napoleone, M | 1 |
| Morgese, G | 2 |
| James, PN | 1 |
| Anderson, JB | 1 |
| Prior, JG | 1 |
| White, JP | 1 |
| Henry, JA | 1 |
| Voyles, W | 1 |
| König, G | 1 |
| Smith, SB | 1 |
| Beck, BW | 1 |
| Patel, KR | 2 |
| Siegel, D | 1 |
| Sheppard, D | 1 |
| Gelb, A | 1 |
| Weinberg, PF | 1 |
| Jenkins, LC | 1 |
| Scoates, PJ | 1 |
| Barish, CF | 1 |
| Wu, WC | 1 |
| Castell, DO | 1 |
| Green, E | 1 |
| Rollins, DL | 1 |
| Coleman, JJ | 1 |
| Barker, AF | 1 |
| Schultz, GE | 1 |
| Scremin, S | 1 |
| Caprioglio, L | 1 |
| Rohr, AS | 3 |
| Fernández García, M | 1 |
| Vermeire, PA | 1 |
| Wittesaele, WM | 1 |
| Janssens, E | 1 |
| De Backer, WA | 1 |
| Hodgkin, JE | 1 |
| Balazs, T | 1 |
| Mistretta, A | 2 |
| Crimi, N | 2 |
| Palermo, F | 2 |
| Wiggins, J | 3 |
| Skareke, L | 1 |
| Segre, G | 1 |
| Henry, PJ | 1 |
| Lulich, KM | 1 |
| Baeza-Bacab, MA | 1 |
| Sienra-Monge, JJ | 1 |
| Joad, J | 1 |
| Olson, LG | 1 |
| Conti Nibali, S | 1 |
| Famulari, C | 1 |
| Pustorino, S | 1 |
| Magazzù, G | 1 |
| Lopez, M | 1 |
| Morris, EC | 1 |
| Kawamura, H | 1 |
| Nagano, H | 1 |
| van Essen-Zandvliet, EE | 1 |
| de Jongste, JC | 1 |
| Brackel, HJ | 1 |
| Scott, GW | 1 |
| Dahlerup, J | 1 |
| Asamoto, H | 2 |
| Kokura, M | 2 |
| Kawakami, A | 2 |
| Sawano, T | 2 |
| Kohara, N | 1 |
| Kitamura, Y | 1 |
| Oishi, T | 1 |
| Morishita, H | 1 |
| Hubert, D | 1 |
| Gaudric, M | 1 |
| Guerre, J | 1 |
| Lockhart, A | 1 |
| Marsac, J | 1 |
| Aubas, P | 1 |
| Korri, UM | 1 |
| Salaspuro, M | 1 |
| Williams, WR | 1 |
| Kagamimori, S | 1 |
| Kakiuchi, H | 1 |
| Naruse, Y | 1 |
| Ekström, TK | 1 |
| Tibbling, LI | 1 |
| Christopher, MA | 1 |
| Rappaport, L | 1 |
| Coffman, H | 1 |
| Guare, R | 1 |
| Fenton, T | 1 |
| DeGraw, C | 1 |
| Twarog, F | 1 |
| Jackson, SH | 2 |
| Woollard, R | 1 |
| Garty, M | 4 |
| Paul-Keslin, L | 1 |
| Spitzer, S | 2 |
| Rosenfeld, JB | 3 |
| Sette, L | 1 |
| Vallone, G | 2 |
| Messori, A | 1 |
| Kneebone, GM | 1 |
| Green, B | 1 |
| Hughes, HM | 1 |
| Ilfeld, D | 2 |
| Feierman, E | 1 |
| Kuperman, O | 1 |
| Lahat, N | 1 |
| Nir, E | 1 |
| Horenstien, L | 1 |
| Owens, GR | 1 |
| Guyatt, G | 1 |
| Sackett, D | 1 |
| Taylor, DW | 1 |
| Chong, J | 1 |
| Roberts, R | 1 |
| Pugsley, S | 1 |
| Perrotin, D | 1 |
| Boissinot, E | 1 |
| Ginies, G | 1 |
| Spitzer, SA | 1 |
| Ryan, CA | 1 |
| Willan, AR | 1 |
| Wherrett, BA | 1 |
| McGovern, JP | 3 |
| Bibi, H | 1 |
| Shapira, H | 1 |
| Schwartz, Y | 1 |
| Fink, A | 1 |
| Nielsen, NH | 1 |
| Madsen, F | 1 |
| Svendsen, UG | 1 |
| Almind, M | 1 |
| Frølund, L | 1 |
| Kurland, G | 2 |
| Leong, AB | 1 |
| Fredholm, BB | 1 |
| Salonen, RO | 1 |
| Weth, G | 1 |
| Koch, H | 1 |
| Haubitz, J | 1 |
| Papadimitriou, JM | 1 |
| Self, HM | 1 |
| Andersson, KE | 1 |
| van As, A | 1 |
| Chick, TW | 2 |
| Bodman, SF | 1 |
| Storms, WW | 1 |
| Nathan, RA | 1 |
| Selner, JC | 1 |
| Koepke, JW | 1 |
| Bewtra, AK | 1 |
| Nair, N | 1 |
| Hamelink, ML | 2 |
| Hochberg, Z | 1 |
| Kraiem, Z | 1 |
| Yamazaki, K | 1 |
| Kuehl, FA | 1 |
| Zanetti, ME | 1 |
| Soderman, DD | 1 |
| Miller, DK | 1 |
| Ham, EA | 1 |
| Helm, SG | 1 |
| Meltzer, SM | 1 |
| Calcutt, L | 2 |
| Hodder, RV | 2 |
| Aitken, TL | 1 |
| Owen, S | 1 |
| Stone, P | 1 |
| Campbell, L | 1 |
| Webster, S | 1 |
| Woodstock, AA | 1 |
| Crummie, A | 1 |
| Bastyr, MH | 1 |
| Casasín Edo, T | 1 |
| Llusa Arbos, M | 1 |
| Gómez Papi, A | 1 |
| Closa Monasterolo, R | 1 |
| Tarrés Roure, A | 1 |
| Vaughan, LM | 2 |
| Harris, JB | 1 |
| Morikawa, T | 1 |
| Igarashi, Y | 1 |
| Barlow, TJ | 1 |
| Graham, P | 1 |
| Harris, JM | 1 |
| Hartley, JP | 1 |
| Turton, CW | 1 |
| Bellia, V | 1 |
| Ferrara, G | 2 |
| Cibella, F | 1 |
| Cuttitta, G | 1 |
| Visconti, A | 1 |
| Insalaco, G | 1 |
| Mirto, M | 1 |
| Peralta, G | 1 |
| Wasek, Z | 1 |
| Kruszewski, J | 1 |
| Józefczak, E | 1 |
| Raczka, A | 1 |
| Sivananthan, N | 1 |
| Kana, D | 1 |
| Winson, MD | 1 |
| Roberts, KN | 1 |
| Dower, JC | 1 |
| Green, RJ | 1 |
| Achermann, R | 1 |
| Medici, TC | 1 |
| Mazzoni, L | 1 |
| Sanjar, S | 1 |
| Hussein, A | 2 |
| von der Hardt, H | 1 |
| Müller, W | 1 |
| Schell, SM | 1 |
| Haltom, JR | 3 |
| Canny, GJ | 2 |
| Rothwell, RP | 1 |
| Holst, PE | 1 |
| Gillies, AJ | 1 |
| Levy, J | 2 |
| Gal, P | 1 |
| Sharpless, MK | 1 |
| Mikhail, MS | 1 |
| Hunsinger, SY | 1 |
| Goodwin, SR | 1 |
| Poynter, D | 1 |
| Thorne, KJ | 1 |
| Richardson, BA | 1 |
| Butterworth, AE | 1 |
| Hay, I | 1 |
| Hertel, G | 1 |
| König, J | 1 |
| Pyun, BY | 1 |
| Obata, T | 2 |
| Forderer, A | 1 |
| Abelitis, M | 1 |
| Koch, I | 1 |
| Trainin, N | 1 |
| Jónsson, S | 1 |
| Kjartansson, G | 1 |
| Gíslason, D | 1 |
| Helgason, H | 1 |
| van den Brink, WT | 1 |
| Subramaniam, S | 1 |
| Dhand, R | 1 |
| Sharma, PL | 1 |
| Gawchik, S | 1 |
| Dunckley, GC | 1 |
| Anderson, DA | 1 |
| Mitsuoka, JC | 1 |
| Marquardt, ED | 1 |
| Triplett, RF | 1 |
| Kuthiala, C | 1 |
| Squire, EN | 1 |
| Souto Martínez, I | 1 |
| Duque Hernández, J | 1 |
| Galván Tudela, L | 1 |
| Alvarez Sanz, E | 1 |
| Díaz Gómez, MI | 1 |
| Kacírek, S | 1 |
| Ekström, T | 1 |
| Tibbling, L | 1 |
| Merland, N | 1 |
| Cartier, A | 2 |
| L'Archevêque, J | 2 |
| Malo, JL | 2 |
| Stirling, F | 1 |
| Gea, J | 1 |
| de Pablo, J | 1 |
| Martí, J | 1 |
| Pujol, A | 1 |
| Fujii, H | 1 |
| Iso, S | 1 |
| Ooishi, T | 1 |
| Ohara, N | 1 |
| Shaw, KN | 1 |
| Schwartz, JS | 1 |
| Rattenbury, JM | 1 |
| Tsanakas, J | 1 |
| Heydolph, F | 1 |
| Budde, R | 1 |
| Yoshimura, K | 1 |
| Nakatani, T | 1 |
| Nakamori, Y | 1 |
| Chonabayashi, N | 1 |
| Tanimoto, H | 1 |
| Cibier-Raphaël, V | 1 |
| Hruskovic, J | 1 |
| Cervenka, J | 1 |
| Brezina, J | 1 |
| Kayserová, H | 1 |
| Kurzawa, R | 1 |
| Gaweł, J | 1 |
| Matoga, S | 1 |
| Rudnik, J | 1 |
| Werys, R | 1 |
| Wissow, LS | 1 |
| Warshow, M | 1 |
| Box, J | 1 |
| Baker, D | 1 |
| Shier, JM | 1 |
| Boeckx, RL | 1 |
| Nguyen, QC | 1 |
| Mattey, JE | 1 |
| Altieri, MF | 1 |
| Klein, BL | 1 |
| Ochsenschlager, DW | 1 |
| Rentsch, E | 1 |
| Heins, M | 2 |
| Kurtin, L | 2 |
| Maes, R | 1 |
| Bucholtz, GA | 1 |
| Newton, JJ | 1 |
| Perhach, JL | 1 |
| Horn, H | 1 |
| Hagenmeier, A | 1 |
| Würtemberger, G | 1 |
| Cottle, AL | 1 |
| Larcher, VF | 1 |
| Fedoseev, GB | 1 |
| Kriakunov, KN | 1 |
| Leĭchenko, LV | 1 |
| Evartau, EE | 1 |
| Reuss, G | 3 |
| Jörres, R | 4 |
| Conrad, EA | 1 |
| Wilkens, H | 1 |
| Pauchet, F | 1 |
| Gervais, A | 1 |
| Levi, F | 1 |
| Chaouat, D | 1 |
| Abella, ML | 1 |
| Zidani, R | 1 |
| Frankoff, HM | 1 |
| Gianotti, L | 1 |
| Hsi, B | 1 |
| Hiatt, PH | 1 |
| Wong, TK | 1 |
| Marbella, A | 1 |
| Meltzer, A | 1 |
| Bose, B | 1 |
| Cater, JI | 1 |
| Clark, RA | 1 |
| Smith, SR | 1 |
| Stableforth, DE | 3 |
| Skinner, C | 1 |
| Kendall, MJ | 1 |
| Bida, C | 1 |
| Moreau, L | 1 |
| Snidero, M | 1 |
| Beziau, H | 1 |
| Fournier, JP | 1 |
| Rasaiah, B | 1 |
| Sallent, J | 1 |
| Stecenko, A | 1 |
| McKenzie, M | 1 |
| Versteegh, FG | 1 |
| Pang, JA | 1 |
| Zhang, YG | 1 |
| Swaminathan, R | 1 |
| Baker, JR | 1 |
| Moessner, H | 1 |
| Gonzalez, U | 1 |
| Grabenstein, J | 1 |
| Renard, R | 1 |
| DeNapoli, T | 1 |
| Schuster, B | 1 |
| Brunette, MG | 1 |
| Lands, L | 1 |
| Thibodeau, LP | 1 |
| Juan, D | 1 |
| Shin, SG | 1 |
| Holmes, T | 1 |
| Hughes, RL | 1 |
| Brenner, M | 1 |
| Berkowitz, R | 2 |
| Marshall, N | 1 |
| Cannizzaro, GF | 1 |
| Pesce, L | 1 |
| Zanoli, P | 1 |
| Milani, GF | 1 |
| Zannoni, F | 1 |
| Pivirotto, F | 1 |
| Pillai, G | 1 |
| Combes, A | 1 |
| Sablayrolles, B | 2 |
| Rodriguez, F | 1 |
| Labbé, A | 1 |
| Patau, JP | 1 |
| Walters, L | 1 |
| Amitai, Y | 1 |
| Fairshter, RD | 3 |
| Thompson, J | 1 |
| Lewis, G | 1 |
| Levy, DS | 1 |
| Krzanowski, JJ | 1 |
| Polson, JB | 1 |
| Ishizaki, T | 3 |
| Minegishi, A | 1 |
| Morishita, M | 1 |
| Kanagawa, S | 2 |
| Nagai, T | 2 |
| Guill, MF | 1 |
| Pruitt, AW | 1 |
| Lawless, TE | 1 |
| Brown, DA | 1 |
| DuRant, RH | 1 |
| Bottini, PB | 1 |
| Chauvet, JP | 1 |
| Psychoyos, I | 1 |
| Proteau, J | 1 |
| Quaedvlieg, M | 1 |
| Greve, LH | 1 |
| Janson-Bjerklie, S | 1 |
| Shnell, S | 1 |
| Kirsten, D | 1 |
| Mäder, I | 1 |
| Klech, H | 1 |
| Williams, PE | 2 |
| Alwazir, YA | 2 |
| Littley, M | 1 |
| Buss, DC | 1 |
| John, R | 1 |
| Routledge, PA | 2 |
| Lazarus, JH | 1 |
| Distefano, SM | 1 |
| Vancheri, C | 1 |
| Ciccarello, C | 1 |
| Palermo, B | 1 |
| Oliveri, R | 1 |
| Domínguez Granados, R | 1 |
| Pita Calandre, E | 1 |
| Girón Caro, F | 1 |
| Gómez Rubio, M | 1 |
| Molina Font, JA | 1 |
| Habananada, S | 1 |
| Pinthong, T | 1 |
| Wattanapermpool, J | 1 |
| Geadsomnuig, S | 2 |
| Tanaka, N | 1 |
| Noguchi, E | 1 |
| Clary, C | 1 |
| Wald, JA | 1 |
| Friedman, BF | 1 |
| Farr, RS | 1 |
| Principi, N | 2 |
| Onorato, J | 2 |
| Giuliani, MG | 1 |
| Vigano, A | 2 |
| Oliver, W | 1 |
| Chapman, D | 1 |
| Chua, YY | 1 |
| Woo, N | 1 |
| Amaro-Galvez, R | 1 |
| Misener, C | 1 |
| Fox, Z | 1 |
| Aranda, J | 1 |
| Giuliani, M | 1 |
| Kaufman, HS | 1 |
| Kvitash, VI | 1 |
| Modin, GW | 1 |
| Wai, MC | 1 |
| Levene, S | 2 |
| Hannaway, PJ | 1 |
| Hopper, GD | 1 |
| Rachelefsky, G | 1 |
| Rohr, A | 1 |
| Wo, J | 2 |
| Gracey, V | 1 |
| Venho, K | 1 |
| Hendy, MS | 1 |
| Burge, PS | 2 |
| Vandewalker, ML | 1 |
| Kray, KT | 1 |
| Dubey, GR | 1 |
| Dabholkar, SV | 1 |
| Kamat, SR | 1 |
| Mahashur, AA | 1 |
| Shah, SP | 1 |
| Sonaje, AG | 1 |
| Athawale, SS | 1 |
| Finiguerra, M | 1 |
| Morandini, GC | 1 |
| Bennati, D | 2 |
| Miglioranzi, P | 1 |
| Gaburro, D | 1 |
| Miech, RP | 1 |
| Stein, M | 1 |
| Davies, H | 2 |
| Stroobant, J | 2 |
| Leakey, T | 1 |
| Houlsby, WT | 1 |
| Joad, JP | 2 |
| Lindgren, SD | 2 |
| Arbab, OA | 1 |
| Jukkara, A | 1 |
| Reyes de la Rocha, S | 1 |
| Brown, MA | 1 |
| Mariño, E | 1 |
| Noseda, A | 1 |
| Lagier, F | 1 |
| Kubo, M | 2 |
| Mazurek, W | 1 |
| Halawa, B | 1 |
| Navarro, M | 1 |
| Durán, JA | 1 |
| Delgado, JA | 1 |
| Serrano, JS | 1 |
| González Hachero, J | 1 |
| Schaber, DE | 1 |
| Scolnik, D | 1 |
| Danziger, Y | 2 |
| Steffensen, G | 2 |
| Kester, MB | 1 |
| Saccar, CL | 2 |
| Rocci, ML | 2 |
| Uematsu, F | 2 |
| Cousins, L | 1 |
| Zeiger, R | 1 |
| Murphy, E | 1 |
| Hannon, D | 1 |
| Slaughter, RL | 1 |
| Goldberg, A | 1 |
| Choi, L | 1 |
| Adams, E | 1 |
| Monego, A | 1 |
| Infortuna, M | 1 |
| Santisi, G | 1 |
| Picciolo, A | 1 |
| Robusto, C | 1 |
| de Candussio, G | 1 |
| Schultz-Werninghaus, G | 1 |
| Fernández de Gatta, MR | 1 |
| Martín, J | 1 |
| de Portugal, J | 2 |
| Michalicková, J | 1 |
| Kapellerová, A | 1 |
| Sulko, M | 1 |
| Mikhail, MN | 1 |
| Catania, PN | 1 |
| Dupeyron, JP | 1 |
| Coignet, MC | 1 |
| Bedos, JP | 1 |
| Poirier, T | 1 |
| de Fenoyl, O | 1 |
| Ascher, E | 1 |
| Guérin, JM | 1 |
| Meyer, P | 1 |
| Habib, Y | 1 |
| Blot, P | 2 |
| Doboszyńska, A | 1 |
| Mutandwa, P | 1 |
| Neill, P | 1 |
| Lindsjö, M | 1 |
| Strandberg, K | 1 |
| Wiholm, BE | 1 |
| Lin, FJ | 1 |
| Kuo, HT | 1 |
| Huang, WC | 1 |
| Lee, CM | 1 |
| Nagashima, K | 1 |
| Yagi, H | 1 |
| Tajima, K | 2 |
| Nicora, M | 1 |
| Beretta, A | 1 |
| Valletta, E | 2 |
| Bernocchi, D | 1 |
| Battistini, E | 1 |
| Spallarossa, D | 1 |
| Zappa, GF | 1 |
| Frías, J | 1 |
| Carcas Sansuan, C | 1 |
| Castro, MA | 1 |
| López Serrano, MC | 1 |
| Alzamora, FM | 1 |
| Wiener, MB | 2 |
| Dutoit, JI | 1 |
| Salome, CM | 1 |
| Woolcock, AJ | 1 |
| Kusenbach, G | 1 |
| Johnson, E | 1 |
| Tuft, L | 1 |
| Logvinoff, MM | 1 |
| Weinstein, DB | 1 |
| Watts, MT | 1 |
| Seifert, B | 1 |
| Gianotti, A | 1 |
| Bottino, G | 1 |
| Izquierdo, I | 1 |
| Torrent, J | 1 |
| Cisteró, A | 1 |
| Jané, F | 1 |
| De Giorgis, A | 1 |
| Brienza, T | 1 |
| Farri, A | 1 |
| Blyden, GT | 1 |
| LeDuc, BW | 1 |
| Greenblatt, DJ | 1 |
| de Villiers, FP | 1 |
| Roberts, JR | 1 |
| Desai, HI | 1 |
| Rodvold, KA | 1 |
| Paloucek, FP | 1 |
| Zell, M | 2 |
| Reed, RC | 1 |
| Cheung, CM | 1 |
| Soldin, SJ | 1 |
| Conrad, E | 2 |
| Lochmanová, A | 1 |
| Borysová, L | 1 |
| Lochman, I | 1 |
| Cohen, E | 1 |
| Uematsu, T | 1 |
| Follath, F | 1 |
| Shah, K | 1 |
| Mangiacavallo, A | 1 |
| Bonsignore, G | 1 |
| Koenig, HG | 1 |
| Blake, RL | 1 |
| Leuenberger, P | 1 |
| Bottoms, SF | 1 |
| Boike, GM | 1 |
| Wald, J | 1 |
| Takishima, T | 1 |
| Teramichi, Y | 1 |
| Schenk, H | 1 |
| Dougherty, C | 1 |
| O'Donnell, D | 1 |
| Cotter, P | 1 |
| Kennedy, N | 1 |
| Chow, MJ | 1 |
| Debruyne, D | 1 |
| Jehan, A | 1 |
| Bigot, MC | 1 |
| Lechevalier, B | 1 |
| Prevost, JN | 1 |
| Moulin, M | 1 |
| Drebinger, K | 1 |
| Dittberner, H | 1 |
| Baum, D | 1 |
| Carter, BL | 1 |
| Driscoll, CE | 1 |
| Lary, H | 1 |
| Aubry, P | 1 |
| Levi-Valensi, P | 1 |
| Jones, LM | 1 |
| Nosaka, H | 2 |
| Mangura, BT | 1 |
| Maniatis, T | 1 |
| Abdel Rahman, MS | 1 |
| Bartholf, R | 1 |
| Clarke, DF | 1 |
| Werbowsky, OL | 1 |
| Grodin, MA | 1 |
| Shargel, L | 1 |
| Neeb, U | 1 |
| Teo, J | 1 |
| Teo, PC | 1 |
| Hibberd, SG | 1 |
| Alveyn, C | 1 |
| Leslie, S | 1 |
| Watanabe, A | 1 |
| Urata, C | 1 |
| Nomoto, H | 1 |
| Mizobe, M | 1 |
| Abe, Y | 1 |
| Miyamato, Y | 1 |
| Spedini, C | 1 |
| Lombardi, C | 1 |
| Scano, G | 1 |
| Lo Conte, C | 1 |
| Spinelli, A | 1 |
| Duranti, R | 1 |
| Gigliotti, F | 1 |
| Turco, R | 1 |
| Stendardi, L | 1 |
| Emmi, L | 1 |
| Arcangeli, P | 1 |
| Adelson, J | 1 |
| Gavalov, SM | 1 |
| Ivanova, TA | 1 |
| Kondiurina, EG | 1 |
| Nell, PA | 1 |
| Ayesh, R | 1 |
| Alton, E | 1 |
| Essex, EG | 1 |
| Hetzel, MR | 1 |
| Ciofetta, G | 1 |
| De Castro, G | 1 |
| Lo Tesoriere, A | 1 |
| Barretta, MA | 1 |
| Lalia, F | 1 |
| Zicari, AM | 1 |
| Ronchetti, R | 1 |
| Lowe, JE | 1 |
| Wilson, AF | 1 |
| Salness, K | 1 |
| Novey, HS | 1 |
| Direkwattanachai, C | 1 |
| Phanichyakarn, P | 1 |
| Srianujatra, S | 1 |
| Masters, B | 1 |
| Mitchell, I | 1 |
| Moore, D | 1 |
| Kleisbauer, JP | 1 |
| Mazoyer, F | 1 |
| Jaber, M | 1 |
| Schneider, AT | 2 |
| Goldstein, S | 1 |
| Sergiou, H | 1 |
| Bjornson, L | 1 |
| Chiaramonte, LT | 2 |
| Verbeek, PR | 1 |
| Atkins, ME | 1 |
| Harrison, D | 1 |
| Tilles, DS | 1 |
| Hales, CA | 1 |
| Stump, N | 1 |
| Geppe, NA | 1 |
| Sokolovskiĭ, GA | 1 |
| Akhmatalieva, MA | 1 |
| Zanić-Matanić, D | 1 |
| Miller, E | 2 |
| Cole, WQ | 1 |
| Despotović, N | 1 |
| Rosić, D | 1 |
| Vidanović, M | 1 |
| Bojović, I | 1 |
| Bozović, M | 1 |
| Glazebrook, KN | 1 |
| MacKintosh, DA | 1 |
| Baird-Lambert, J | 1 |
| Summer, WR | 1 |
| Cohen, RM | 1 |
| Lindberg, R | 1 |
| Ivaska, K | 1 |
| Irjala, K | 1 |
| Massanari, M | 1 |
| Sheffer, AL | 1 |
| Dobken, JH | 1 |
| Rosenthal, RR | 1 |
| Rappaport, I | 1 |
| Buckley, CE | 1 |
| Janky, DG | 1 |
| Edelman, L | 1 |
| De Stefano, G | 1 |
| Richelli, C | 1 |
| Carrier, JA | 1 |
| Shaw, RA | 1 |
| Allison, EJ | 1 |
| Kessler, ER | 1 |
| Woody, DG | 1 |
| Harker, CC | 1 |
| Jones, JG | 1 |
| Wallis, PJ | 1 |
| Joy, M | 1 |
| Hughes, DT | 1 |
| Empey, DW | 1 |
| Pedersen, BK | 1 |
| Faurschou, P | 1 |
| Carson, JW | 1 |
| Cagney, B | 1 |
| Taylor, MR | 1 |
| Lindemann, H | 1 |
| Bauer, J | 1 |
| Schwandt, HJ | 1 |
| Springer, C | 1 |
| Goldenberg, B | 1 |
| Ben Dov, I | 1 |
| Marney, SR | 1 |
| Daly, WJ | 1 |
| Rhind, GB | 1 |
| Connaughton, JJ | 1 |
| McFie, J | 1 |
| Bonstein, H | 1 |
| Burns, RB | 1 |
| Litt, M | 1 |
| Stutz, P | 1 |
| Schwartz, E | 1 |
| Bukstein, D | 1 |
| Grunstein, M | 1 |
| Leeder, JS | 1 |
| Seggev, JS | 1 |
| Shefi, M | 1 |
| Schey, G | 1 |
| Farfel, Z | 1 |
| Alessandri, MV | 1 |
| Zocca, E | 1 |
| Pozzan, M | 1 |
| Guss, C | 1 |
| Rongved, G | 1 |
| Westlie, L | 1 |
| Lemire, I | 1 |
| Martin, RR | 1 |
| Díaz Fernández, M | 1 |
| Gracía Hidalgo, A | 1 |
| Mateo Cañas, G | 1 |
| López Elorze, F | 1 |
| Cuskey, W | 1 |
| Curtis, RA | 1 |
| Troyer, WG | 1 |
| Fischer, JH | 1 |
| Shucard, DW | 1 |
| Euwer, RL | 1 |
| Cummins, KR | 1 |
| Shucard, JL | 1 |
| Friedman, A | 1 |
| Volwitz, B | 1 |
| Kuzemko, JA | 1 |
| Le Cotonnec, JY | 1 |
| Simpson-Laing, JE | 1 |
| Weibel, MA | 1 |
| Yernault, JC | 1 |
| Sternon, J | 1 |
| Gottschalk, R | 1 |
| Bouslama, A | 1 |
| Bouchoucha, S | 1 |
| Grandory, B | 1 |
| Wood, PR | 1 |
| Casey, R | 1 |
| McCormick, MC | 1 |
| Kodera, S | 1 |
| Misawa, M | 1 |
| Yanaura, S | 1 |
| Ishimura, K | 1 |
| Feinstein, RA | 1 |
| Tukiainen, H | 1 |
| Nykänen, S | 1 |
| Saano, V | 1 |
| Kravis, LP | 1 |
| Powell-Jackson, PR | 1 |
| Jamieson, AP | 1 |
| Gray, BJ | 1 |
| Moxham, J | 1 |
| Williams, R | 1 |
| Bayliff, CD | 1 |
| Koch, JP | 1 |
| Faclier, G | 1 |
| Payne, DK | 1 |
| Hindi-Alexander, MC | 1 |
| Zielezny, MA | 1 |
| Montes, N | 1 |
| Bullough, B | 1 |
| Rosner, DH | 1 |
| London, WM | 1 |
| Danish, M | 1 |
| Ragni, MC | 1 |
| Greene, J | 1 |
| Auritt, WA | 1 |
| Nieto, A | 1 |
| Mazón, A | 1 |
| Caballero, L | 1 |
| Gil, MC | 1 |
| Colin, A | 2 |
| Shachar, H | 1 |
| Nichols, AI | 1 |
| Baker, J | 1 |
| Lenert, LL | 1 |
| Ezra, D | 1 |
| Póder, G | 1 |
| Tótfalusi, L | 1 |
| Mezei, G | 1 |
| Tóth, UK | 1 |
| Berg, SJ | 1 |
| Balant, LP | 1 |
| Clarke, I | 1 |
| Laher, MS | 1 |
| O'Regan, P | 1 |
| Jackson, F | 1 |
| MacCarthy, E | 1 |
| Wright, E | 1 |
| Counihan, TB | 1 |
| Keelan, P | 1 |
| Bolaños, IF | 1 |
| Mínguez, A | 1 |
| Vallespín, J | 1 |
| Fournier-Massey, G | 1 |
| Massey, DG | 1 |
| Price, S | 1 |
| McLaughlin, DG | 1 |
| Gordon, BL | 1 |
| Shinagawa, Y | 1 |
| Ohta, H | 1 |
| Inui, H | 1 |
| Umesato, Y | 1 |
| Nishikawa, K | 1 |
| Arai, H | 1 |
| Mitsuhashi, M | 1 |
| Kido, M | 1 |
| Ogawa, Y | 1 |
| Hiura, T | 1 |
| Miyamoto, S | 1 |
| Swigart, SA | 1 |
| Smith, KL | 1 |
| Kalla, M | 1 |
| Graatsma, BH | 1 |
| Mayer, L | 1 |
| Zinman, P | 1 |
| Hoffer, E | 1 |
| Teitelman, U | 1 |
| Rubin, A | 1 |
| Dutau, G | 1 |
| Perrin, B | 1 |
| Pienkowski, C | 1 |
| Gillet, A | 1 |
| Rochiccioli, P | 1 |
| Chan, KW | 1 |
| Ti, TY | 1 |
| Tan, TH | 1 |
| Feng, PH | 1 |
| Patchett, P | 1 |
| Patchett, SM | 1 |
| Tullett, WM | 1 |
| Murphy, DH | 1 |
| Fink, JN | 1 |
| Levy, MB | 1 |
| Child, S | 1 |
| MacLeod, JP | 1 |
| Prazáková, J | 1 |
| Seebohm, PM | 1 |
| Van Cauwenberge, H | 1 |
| Hyde, JS | 2 |
| Floro, LD | 1 |
| McDonald, JR | 1 |
| Tan, EM | 1 |
| Vaughan, JH | 1 |
| Iurenev, PN | 1 |
| Frolova, MK | 1 |
| Pashkova, TL | 1 |
| Makarov, AN | 1 |
| Havnen, J | 1 |
| Shenfield, GM | 1 |
| Straub, PW | 1 |
| Bühlmann, AA | 1 |
| Rossier, PH | 1 |
| Buck, C | 1 |
| McCourtie, DR | 1 |
| Hudson, LD | 1 |
| Tyler, ML | 1 |
| Illig, H | 1 |
| Mangold, H | 1 |
| Fiedelman, W | 1 |
| Martens, J | 1 |
| Block, SH | 1 |
| Williams, SE | 1 |
| Parrillo, OJ | 1 |
| Humoller, FL | 1 |
| Demonet, B | 2 |
| Charles, A | 2 |
| Serizay, B | 2 |
| Vialatte, J | 1 |
| Ellorhaoui, M | 1 |
| Douglas, JS | 1 |
| Lewis, A | 1 |
| Parker, CW | 3 |
| Baumann, ML | 2 |
| Huber, MG | 2 |
| Belloni, L | 1 |
| Savioli, F | 1 |
| Simkó, A | 1 |
| Martelli, A | 1 |
| Rapp, DJ | 1 |
| Freedman, SO | 1 |
| Dworetzky, M | 1 |
| Furkert, K | 1 |
| Vertua, R | 1 |
| Caffau, S | 1 |
| Fontana, A | 2 |
| Ballerini, G | 1 |
| Renovanz, HD | 2 |
| Kiehelä, J | 1 |
| Keskinen, H | 1 |
| Hohenthal, TT | 1 |
| Dolcetti, A | 1 |
| Motta, PE | 1 |
| Gaino, T | 1 |
| Jllig, H | 1 |
| Perrault, M | 1 |
| Smith, JW | 1 |
| Weinberg, EG | 2 |
| Shore, SC | 2 |
| Subramanian, N | 1 |
| Narasimhan, SV | 1 |
| Nalini, S | 1 |
| Herxheimer, H | 1 |
| Naess, K | 1 |
| Licata, G | 1 |
| Indovina, I | 1 |
| Durante, F | 1 |
| Wells, FO | 1 |
| Stewart, CJ | 1 |
| Iisalo, E | 1 |
| Späth, G | 1 |
| Blumstein, CG | 1 |
| Whitcomb, NJ | 1 |
| Rubinstein, E | 1 |
| Paramelle, F | 1 |
| May, CD | 1 |
| Anderton, M | 1 |
| Mitenko, PA | 2 |
| Kessler, H | 1 |
| Fréour, P | 1 |
| Bernadou, M | 1 |
| Chomy, P | 1 |
| Nicholson, DP | 1 |
| Garrido, R | 1 |
| Silverman, HI | 1 |
| Halbrecht, I | 1 |
| Komlos, L | 1 |
| Shabtay, F | 1 |
| Solomon, M | 1 |
| Böök, JA | 1 |
| Schwarz, KG | 1 |
| Schwarz, CM | 1 |
| Lespagnol, A | 1 |
| Debaert, M | 1 |
| Blears, A | 1 |
| Devergnies, M | 1 |
| Cazin, JC | 1 |
| Cazin, M | 1 |
| Williams, MH | 1 |
| Morris, HG | 1 |
| DeRoche, G | 1 |
| Winkler, SM | 1 |
| Caro, CM | 1 |
| Gomez, J | 1 |
| Gomez, G | 1 |
| Taylor, WF | 4 |
| Busser, RJ | 1 |
| Heimlich, EM | 2 |
| Aepli, R | 2 |
| Günthner, W | 2 |
| Haslreiter, E | 1 |
| Krieger, E | 2 |
| Epstein, N | 1 |
| Brantingham, P | 1 |
| Marx, HH | 1 |
| Becker, E | 1 |
| Tivenius, L | 1 |
| Palecek, I | 1 |
| Stamm, SJ | 1 |
| Van Arsdel, PP | 1 |
| Swarts, C | 1 |
| Hagelund, CH | 1 |
| Ballerini, C | 1 |
| Kane, FJ | 1 |
| Florenzano, R | 1 |
| Dubois de Montreynaud, JM | 2 |
| Kochman, S | 1 |
| Cazabat, A | 1 |
| Candas, JC | 1 |
| Moreno González, A | 1 |
| Lorenzo Fernández, P | 1 |
| Brkich, J | 1 |
| Helander, S | 1 |
| Lindell, SE | 1 |
| Söderholm, B | 1 |
| Westling, H | 1 |
| Finke, SR | 1 |
| Castro, EJ | 1 |
| da Silva, AC | 1 |
| Busser, R | 1 |
| Radic, P | 1 |
| Long, C | 1 |
| Dinda, P | 1 |
| Riding, WD | 1 |
| Singh, T | 1 |
| Hammer, O | 1 |
| Melich, H | 1 |
| Casal, GL | 1 |
| Blamoutier, J | 1 |
| Mot, JC | 1 |
| Travagli, JP | 1 |
| Qaqundah, BY | 1 |
| Stănescu, DC | 1 |
| Teculescu, DB | 1 |
| Legge, JS | 1 |
| Gaddie, J | 1 |
| Swineford, O | 1 |
| Castaing, R | 1 |
| Bellet, M | 1 |
| Howard, LA | 1 |
| Dlouhy, R | 1 |
| Geisler, L | 1 |
| Klein, HG | 1 |
| Iven, A | 1 |
| de Lostalot, J | 1 |
| Breuer, H | 1 |
| Kösters, W | 1 |
| Kluthe, R | 1 |
| Pauly, VR | 2 |
| Gürtler, J | 1 |
| Lillehei, JP | 1 |
| Riethling, AK | 1 |
| Kiepe, B | 1 |
| Press, P | 1 |
| Frouchtman, R | 1 |
| Pindinelli, C | 1 |
| Bianchini, AM | 1 |
| La Cauza, C | 1 |
| Paul, K | 1 |
| Hansen, P | 1 |
| Göbel, P | 1 |
| Göbel-Rieken, E | 1 |
| Köster, E | 1 |
| Levine, ER | 1 |
| Ramel, C | 1 |
| Yunginger, JW | 1 |
| Smith, I | 1 |
| Keitel, HG | 1 |
| Wendt, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy Of Doxophylline As A Sparing Treatment For Inhaled Corticosteroids In Mexican Children With Asthma[NCT03879590] | Phase 3 | 60 participants (Anticipated) | Interventional | 2019-05-31 | Not yet recruiting | ||
| A Clinical Study to Investigate the Effect of Rosiglitazone, Theophylline and Inhaled Corticosteroid, Inflammation and Pulmonary Function in Asthmatic Smokers[NCT00119496] | Phase 2/Phase 3 | 79 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| General Anesthesia in Obstetric Patients for Cesarean Section, Maternal and Perinatal Outcomes[NCT06160583] | 5,000 participants (Actual) | Observational [Patient Registry] | 2023-11-12 | Active, not recruiting | |||
| [NCT00217945] | 0 participants | Interventional | 2001-09-30 | Completed | |||
| [NCT00149526] | 0 participants | Interventional | 2001-06-30 | Completed | |||
| Aminophylline for Patients With Post-Dural Puncture Headache: a Prospective, Multi-center, Randomized Controlled Trial[NCT02522013] | Phase 3 | 126 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Effect of Bronchial Thermoplasty on Moderate Bronchial Asthma in China[NCT02965807] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| Assessment of Bronchial Asthma Among Patients Attending Sohag University Hospital[NCT06141161] | 200 participants (Anticipated) | Observational | 2023-11-01 | Recruiting | |||
| [NCT00000578] | Phase 3 | 0 participants | Interventional | 1994-04-30 | Completed | ||
| Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia (FluCOP Trial)[NCT05216614] | Phase 2 | 0 participants (Actual) | Interventional | 2021-12-14 | Withdrawn (stopped due to Unable to obtain investigational product) | ||
| A Randomized Open-Label Comparative Study of Montelukast Versus Theophylline Added to Inhaled Corticosteroid in Pediatric Patients With Bronchial Asthma[NCT00756418] | Phase 4 | 84 participants (Actual) | Interventional | 2003-06-01 | Completed | ||
| [NCT00005279] | 0 participants | Observational | 1971-06-30 | Completed | |||
| Redesigning Ambulatory Care Delivery to Enhance Asthma Control in Children[NCT02409277] | 926 participants (Actual) | Interventional | 2013-08-31 | Completed | |||
| [NCT00005445] | 0 participants | Observational | 1994-04-30 | Completed | |||
| [NCT00005715] | 0 participants | Observational | 1990-08-31 | Completed | |||
| Effects of Breathing Exercises on Asthmatic Pregnant Females[NCT04674943] | 24 participants (Actual) | Interventional | 2020-09-25 | Completed | |||
| Assessment and Evaluation of Pharmacokinetic Profile of E004 in Healthy Adults (A Randomized, Evaluator-Blind, Single-Dose, Two Arm, Crossover, PK Study in Healthy Volunteers)[NCT01737892] | Phase 1/Phase 2 | 21 participants (Actual) | Interventional | 2012-11-30 | Terminated (stopped due to unable to validate analytical method) | ||
| Epinephrine Inhalation Aerosol USP, an HFA-MDI CLINICAL STUDY-B2 FOR ASSESSMENT OF PHARMACOKINETICS (A Randomized, Evaluator-Blind, Single-Dose, Two Arm, Crossover, PK Study in Healthy Volunteers)[NCT01188577] | Phase 1/Phase 2 | 23 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Epinephrine Inhalation Aerosol USP, an HFA-MDI: Clinical Study-C For Evaluation Of Efficacy And Safety In Asthma Patients[NCT01357642] | Phase 3 | 373 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| A 3-month Safety Evaluation Extension to the 12-week E004-C Study in Asthma Patients (A Double Blinded, Placebo-controlled, Parallel, 3-month Safety Study in Adolescent and Adult Patients With Asthma)[NCT01476904] | Phase 3 | 208 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| Evaluation of Efficacy and Safety for Single Dose of E004 in Children With Asthma (A Randomized, Double-Blind, Placebo-Controlled, Crossover, Single Dose Study in 4 - 11 Year Old Children With Asthma)[NCT01737905] | Phase 3 | 28 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| CLINICAL STUDY-B3 FOR ASSESSMENT OF PHARMACOKINETICS, A Randomized, Evaluator-Blind, Single-Dose, Three Arm, Crossover,PK Study in Healthy Volunteers[NCT01255709] | Phase 2 | 24 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| A Randomized, Double-blinded or Evaluator-blinded, Placebo and Active Controlled, Six-arm, Crossover, Single Dose, Dose-ranging Study, for Initial Evaluation of Safety and Efficacy in Asthma Patients[NCT01025648] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to Optimization of protocol) | ||
| Phase III Study of Epinephrine Inhalation Aerosol for Evaluation of Efficacy and Safety of E004 in Children With Asthma[NCT01460511] | Phase 3 | 70 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Combining N-of-1 Trials to Assess Fibromyalgia Therapies[NCT00000428] | Phase 4 | 58 participants (Actual) | Interventional | 2000-09-30 | Completed | ||
| Does a Lipophilic Steroid Inhaled After an Early Allergic Reaction Affect the Late Reaction?[NCT00716963] | Phase 4 | 7 participants (Actual) | Interventional | 2008-07-31 | Completed | ||
| Kinetics of IgE Memory B Cells, Plasmablasts and Plasma Cells After Whole Lung Allergen Challenge in Mild Asthmatics[NCT01420003] | 12 participants (Actual) | Interventional | 2011-11-30 | Completed | |||
| Phase II Study: LYM-X-SORB™, an Organized Lipid Matrix: Fatty Acids and Choline in CF[NCT00406536] | Phase 2 | 110 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
ED and hospital admission evaluated using data collected through Intermountain Healthcare claims data and ED visits and hospital encounters. Statistical analysis was not conducted since the numbers of ED/Hospital admissions was very small (2 and 0) in both group (during the 3 months study window). Here we used intent-to-treat analysis and included the overall 325 (rather than 318 used in analysis of other outcomes) participants. (NCT02409277)
Timeframe: 3-month period prior to the late clinics starting the e-AT
| Intervention | number of ED/Hospital admission (Number) |
|---|---|
| Early Starting Clinics | 2 |
| Late Starting Clinics | 0 |
ED and hospital admission was evaluated using data collected through Intermountain Healthcare claims data and ED visits and hospital encounters. Analyses (at the patient level) comparing the rates of ED/hospital admissions between a 1 year period following initiation of the e-AT for those in both standard and intensive e-AT groups who were enrolled early during the study period (patients with enrollment dates between January 2014 and December 2014) to rates of ED/hospital admissions for patients who started the e-AT later (patients with enrollment dates between January 2015 and December 2015), during a 1-year period prior to the late patient starting the e-AT. (NCT02409277)
Timeframe: 1 year following e-AT use for early and late starting patients
| Intervention | number of ED/Hospital admission (Mean) |
|---|---|
| Early Starting Patients | 0.10 |
| Late Starting Patients | 0.18 |
ED/hospital re-admission data were compared between prior and post 12 month period (for both intensive and standard interventions overall) when e-AT was administered. (NCT02409277)
Timeframe: 1 year
| Intervention | number of ED/hospital admission (Mean) |
|---|---|
| Prior e-AT Use | 0.22 |
| Post e-AT Use | 0.09 |
Use of oral steroid was evaluated using data collected through Intermountain Healthcare claims data and oral steroids prescribed. Statistical analysis was not conducted since the numbers of ED/Hospital admissions was very small (2 and 0) in both group (during the 3 months study window). Here we used intent-to-treat analysis and included the overall 325 (rather than 318 used in analysis of other outcomes) participants (NCT02409277)
Timeframe: 3 month period prior to the late clinics starting the e-AT
| Intervention | number of oral steroid use (Number) |
|---|---|
| Early Patients | 4 |
| Late Patients | 0 |
"Oral steroid use data was collected through Intermountain Healthcare claims data and clinics prescribing oral steroid.~Oral steroid use was evaluated using data collected through Intermountain Healthcare claims data and oral steroids prescribed. Analyses (at the patient level) comparing the rates oral steroid use between a 1 year period following initiation of the e-AT for those in both standard and intensive e-AT groups who were enrolled early during the study period (patients with enrollment dates between January 2014 and December 2014) to rates of oral steroid use for patients who started the e-AT later (patients with enrollment dates between January 2015 and December 2015), during a 1-year period prior to the late patient starting the e-AT." (NCT02409277)
Timeframe: 1 year
| Intervention | number of oral steroid use (Mean) |
|---|---|
| Early Starting Patients | 0.53 |
| Late Starting Patients | 0.53 |
Use of oral steroid was evaluated using data collected through Intermountain Healthcare claims data and oral steroids prescribed. Comparison was made between prior and post e-AT (both interventions) overall. (NCT02409277)
Timeframe: 1 year
| Intervention | number of oral steroid use (Mean) |
|---|---|
| Prior e-AT Use | 0.74 |
| Post e-AT Use | 0.51 |
Asthma control information was collected weekly through the e-AT for 1 year. Asthma control was measured using the Asthma Control Test (ACT), which had a score ranging from 5 to 25, with 5 being poor control and 25 being optimal control. The analysis compared the mean change in scores from baseline to quarters 1, 2, 3, and 4. (NCT02409277)
Timeframe: Average baseline ACT scores compared to average ACT scores at quarter 1, 2, 3 and 4, and between Standard vs. Intensive
| Intervention | mean score (points) change (Mean) | |||
|---|---|---|---|---|
| Qtr 1 vs baseline | Qtr 2 vs baseline | Qtr 3 vs baseline | Qtr 4 vs baseline | |
| Intensive e-AT Intervention | 1.78 | 2.18 | 2.18 | 3.30 |
| Standard e-AT Intervention | 2.55 | 3.09 | 3.26 | 3.33 |
"Asthma control information was collected through the e-AT, comparing change of asthma control from baseline to quarter 1, quarter 2, quarter 3 and quarter 4.~Asthma control was measured using the Asthma Control Test (ACT), which scale ranged from 5-25, with 5=poorly controlled and 25=well controlled.~Each patient submitted an ACT score weekly for 12 months." (NCT02409277)
Timeframe: baseline ACT scores were compared to quarters 1, 2, 3, 4.
| Intervention | Score (points) ranging from 5-25 (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | Quarter 1 | Quarter 2 | Quarter 3 | Quarter 4 | |
| All e-AT Users | 18.85 | 22.28 | 22.82 | 22.81 | 22.97 |
Number of child interrupted/missed school days were collected longitudinally (information includes mean at baseline, 3, 6, and 12 months in the study). (NCT02409277)
Timeframe: 1 year
| Intervention | Number of days (interrupted or missed) (Mean) | |||
|---|---|---|---|---|
| Baseline | 3 Months Follow-up | 6 Months Follow-up | 12 Months Follow-up | |
| All e-AT Users | 1.91 | 0.80 | 0.52 | 0.79 |
"Number of child interrupted/missed school days were collected longitudinally at the same time as collecting the QOL scores: baseline, 3, 6, and 12 months in the study.~Number of child interrupted/missed school days during the 3 months prior to baseline, 3, 6, and 12 months follow-up surveys were counted." (NCT02409277)
Timeframe: Interrupted/missed school days were collected at baseline, 3, 6, and 12 month follow-ups
| Intervention | Number of interrupted/missed school days (Number) | |||
|---|---|---|---|---|
| Baseline | 3 Months Follow-up | 6 Months Follow-up | 12 Months Follow-up | |
| Intensive e-AT Intervention | 129 | 60 | 30 | 37 |
| Standard e-AT Intervention | 435 | 114 | 87 | 129 |
Non randomized comparison of ED and hospital admissions between e-AT interventions (both intensive and standard) compared usual care (matched control patients drawn from non-participating clinics) in the prior vs. post e-AT intervention time periods. (NCT02409277)
Timeframe: 1 year
| Intervention | Rate per 1000-days (Mean) | |
|---|---|---|
| Prior | Post | |
| e-AT Intervention | 0.59 | 0.24 |
| Usual Care (Non-randomized Cohort) | 0.23 | 0.24 |
"ED and hospital admissions were evaluated using data collected through Intermountain Healthcare claims data and ED visits and hospital encounters.~We evaluated number ED and hospital admissions 12 months prior to intervention and 12 months post intervention" (NCT02409277)
Timeframe: Change in 1 year ED/hospital admission between 12-month prior and 12 month post e-AT use
| Intervention | Number of ED/hospital admissions (Number) | |
|---|---|---|
| Prior | Post | |
| Intensive e-AT Intervention | 18 | 8 |
| Standard e-AT Intervention | 53 | 21 |
Non randomized comparison of use of oral steroid between e-AT interventions (both intensive and standard) compared usual care (matched control patients drawn from non-participating clinics) in the prior vs. post e-AT intervention time periods. (NCT02409277)
Timeframe: 1 year
| Intervention | Rate per 1000-days (Mean) | |
|---|---|---|
| Prior | Post | |
| e-AT Intervention | 2.02 | 1.41 |
| Usual Care (Non-randomized Cohort) | 1.87 | 1.99 |
Number of parent interrupted/missed work days were collected longitudinally at the same time as collecting the QOL scores: Information includes mean at baseline, 3, 6, and 12 months in the study. (NCT02409277)
Timeframe: 1 year
| Intervention | Number of days (interrupted or missed) (Mean) | |||
|---|---|---|---|---|
| Baseline | 3 Months Follow-up | 6 Months Follow-Up | 12 Months Follow-up | |
| All e-AT Users | 0.72 | 0.27 | 0.25 | 0.20 |
"Number of parent interrupted/missed work days were collected longitudinally at the same time as collecting the QOL scores: baseline, 3, 6, and 12 months in the study.~Number of parent interrupted/missed work days during the 3 months prior to baseline, 3, 6, and 12 months follow-up surveys were counted." (NCT02409277)
Timeframe: Interrupted/missed work days were measured baseline 3, 6, and 12 months
| Intervention | Number of interrupted/missed work days (Number) | |||
|---|---|---|---|---|
| Baseline | 3 Months Follow-up | 6 Months Follow-up | 12 Months Follow-up | |
| Intensive e-AT Intervention | 56 | 14 | 15 | 18 |
| Standard e-AT Intervention | 176 | 44 | 42 | 23 |
"Parent satisfaction data was collected using a modified version of patient satisfaction survey developed and validated by Varni et al. at baseline and at 12 months in the study.~The scale ranged from 1-5, with 1=Very Dissatisfied and 5=Very Satisfied." (NCT02409277)
Timeframe: Satisfaction at 1 year following e-AT use was compared to baseline satisfaction scores
| Intervention | units (points) on a scale (from 1-5) (Mean) | |
|---|---|---|
| Baseline | 12 months Follow-up | |
| All e-AT Users | 4.66 | 4.46 |
"Parent satisfaction data was collected at baseline and at 12 months in the study.~The scale ranges from 1-5, with 1 being Very Dissatisfied and 5 Very Satisfied." (NCT02409277)
Timeframe: Changes in satisfaction was compared between 12 month follow-up and baseline satisfaction across Standard and Intensive interventions
| Intervention | units (points) on a scale (from 1-5) (Mean) | |
|---|---|---|
| Baseline | 12 months Follow-up | |
| Intensive e-AT Intervention | 4.63 | 4.54 |
| Standard e-AT Intervention | 4.63 | 4.38 |
"Patient QOL and missed school days was collected longitudinally through surveys of the study population defined above. The QOL questionnaire included the Integrated Therapeutics Group Child Asthma Short Form (ITG-CASF) and was used at baseline (at first assessment), 3, 6, and 12 months in the study.~Items within QOL scales are summed and linearly transformed from 0 to 100, with higher scores indicating better functioning." (NCT02409277)
Timeframe: Quality of Life assessed at baseline, then compared to 3 months, 6 months, and 12 months after intervention.
| Intervention | Units on a scale (Mean) | ||
|---|---|---|---|
| 3 Months Follow-up vs Baseline | 6 Months Follow-up compared vs Baseline | 12 Months Follow-up vs Baseline | |
| Intensive e-AT Intervention | 7.64 | 5.78 | 9.29 |
| Standard e-AT Intervention | 8.55 | 8.37 | 9.39 |
Patient QOL and missed school days was collected longitudinally through surveys of the study population defined above. The QOL questionnaire included the Integrated Therapeutics Group Child Asthma Short Form - ITG-CASF and was used at baseline (at first assessment), 3, 6, and 12 months in the study. Items within scales are summed and linearly transformed from 0 to 100, with higher scores indicating better functioning. (NCT02409277)
Timeframe: Average Baseline QOL was compared to QOL scores at 3, 6 and 12 month follow-up QOL
| Intervention | units (points) on a scale, range 0-100 (Mean) | |||
|---|---|---|---|---|
| Baseline | 3 Months | 6 Months | 12 Months | |
| All e-AT Users | 79.07 | 90.98 | 90.04 | 90.64 |
Patient PK blood samples were taken from a vein in a hand or arm via indwelling heparin-anticoagulated IV catheters, or by venipunctures at 0 (baseline), 2, 5, 7.5, 10, 12.5, 15, 20, 25, 30, 45, 60, 90, 120, 240, and 360 minutes post-dose in each treatment period and were analyzed using an established analysis method. Area under the curve from time zero to 6 hours post-dose (AUC[0-6]) was calculated using the trapezoidal rule. (NCT01188577)
Timeframe: Pre-dose to 6 hours post-dose
| Intervention | pg*min/mL (Mean) |
|---|---|
| Treatment T | 8498 |
| Treatment C | 6191 |
Patient PK blood samples were taken from a vein in a hand or arm via indwelling heparin-anticoagulated IV catheters, or by venipunctures at Baseline (prior to dosing) in each treatment period following a specified washout period (3-14 days), and were analyzed using an established analysis method. Baseline concentration (C0) is the concentration of epinephrine measured in the plasma at this time point. (NCT01188577)
Timeframe: 0 to 30 minutes prior to dosing
| Intervention | pg/mL (Mean) |
|---|---|
| Treatment T | 2.6 |
| Treatment C | 4.3 |
Patient PK blood samples were taken from a vein in a hand or arm via indwelling heparin-anticoagulated IV catheters, or by venipunctures at 0 (baseline), 2, 5, 7.5, 10, 12.5, 15, 20, 25, 30, 45, 60, 90, 120, 240, and 360 minutes post-dose in each treatment period and were analyzed using an established analysis method. Half-life (t1/2) is the amount of time it takes for epinephrine to decrease to half the peak concentration in plasma during the treatment period. (NCT01188577)
Timeframe: Pre-dose to 6 hours post-dose
| Intervention | min (Mean) |
|---|---|
| Treatment T | 145.9 |
| Treatment C | 289.8 |
Patient PK blood samples were taken from a vein in a hand or arm via indwelling heparin-anticoagulated IV catheters, or by venipunctures at 0 (baseline), 2, 5, 7.5, 10, 12.5, 15, 20, 25, 30, 45, 60, 90, 120, 240, and 360 minutes post-dose in each treatment period and were analyzed using an established analysis method. Peak (maximum) concentration (Cmax) is the highest concentration of epinephrine measured in plasma during the treatment period. (NCT01188577)
Timeframe: Pre-dose to 6 hours post-dose
| Intervention | pg/mL (Mean) |
|---|---|
| Treatment T | 862 |
| Treatment C | 190 |
Patient PK blood samples were taken from a vein in a hand or arm via indwelling heparin-anticoagulated IV catheters, or by venipunctures at 0 (baseline), 2, 5, 7.5, 10, 12.5, 15, 20, 25, 30, 45, 60, 90, 120, 240, and 360 minutes post-dose in each treatment period and were analyzed using an established analysis method. Tmax is the amount of time it takes for epinephrine to reach peak concentration in plasma during the treatment period. (NCT01188577)
Timeframe: Pre-dose to 6 hours post-dose
| Intervention | min (Mean) |
|---|---|
| Treatment T | 2.3 |
| Treatment C | 3.4 |
Patient PK blood samples were taken from a vein in a hand or arm via indwelling heparin-anticoagulated IV catheters, or by venipunctures at 0 (baseline), 2, 5, 7.5, 10, 12.5, 15, 20, 25, 30, 45, 60, 90, 120, 240, and 360 minutes post-dose in each treatment period and were analyzed using an established analysis method. (NCT01188577)
Timeframe: Pre-dose to 6 hours post-dose
| Intervention | pg/mL (Mean) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 min (Baseline) | 2 min post-dose | 5 min post-dose | 7.5 min post-dose | 10 min post-dose | 12.5 min post-dose | 15 min post-dose | 20 min post-dose | 25 min post-dose | 30 min post-dose | 45 min post-dose | 60 min post-dose | 90 min post-dose | 120 min post-dose | 240 min post-dose | 360 min post-dose | |
| Treatment C | 4.3 | 189.0 | 99.1 | 48.8 | 39.7 | 33.9 | 32.0 | 30.1 | 20.3 | 17.7 | 19.8 | 13.2 | 11.2 | 6.9 | 17.7 | 17.2 |
| Treatment T | 2.6 | 861.5 | 379.4 | 186.6 | 118.3 | 75.6 | 46.8 | 22.9 | 10.9 | 10.5 | 10.5 | 8.7 | 3.5 | 6.5 | 16.1 | 17.1 |
(NCT00716963)
Timeframe: Before inhalation 3 hours
| Intervention | percentage fall FEV1 (Mean) |
|---|---|
| Fluticasone Propionate (Flovent Diskus) 250 mcg | -30.5 |
| Budesonide 400mcg | -39.0 |
| Placebo | -31.9 |
(NCT00716963)
Timeframe: 7 hours after challenge
| Intervention | percentage fall FEV1 (Mean) |
|---|---|
| Fluticasone Propionate (Flovent Diskus) 250 mcg | -11.6 |
| Budesonide 400mcg | -14.7 |
| Placebo | -24 |
413 reviews available for theophylline and Asthma, Bronchial
| Article | Year |
|---|---|
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chr | 2008 |
Clinical pharmacokinetics of terbutaline in humans: a systematic review.
Topics: Administration, Intravenous; Asthma; Female; Humans; Kinetics; Pregnancy; Terbutaline; Theophylline | 2023 |
Theophylline for the management of respiratory disorders in adults in the 21st century: A scoping review from the American College of Clinical Pharmacy Pulmonary Practice and Research Network.
Topics: Adult; Asthma; Bronchodilator Agents; Humans; Hypoxia; Pharmacy; Pulmonary Disease, Chronic Obstruct | 2023 |
The effect of doxofylline in asthma and COPD.
Topics: Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Drug Costs; Economics, Pharmaceutical; Fema | 2020 |
Therapeutic potentials of natural compounds acting on cyclic nucleotide phosphodiesterase families.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Asthma; Biological Products; Cell Line, Tumor; Cell Pr | 2017 |
Doxofylline is not just another theophylline!
Topics: Animals; Asthma; Bronchodilator Agents; Disease Progression; Drug Interactions; Hospitalization; Hum | 2017 |
Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis.
Topics: Acute Disease; Administration, Intravenous; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Hu | 2018 |
Multicomponent Pharmaceutical Cocrystals: A Novel Approach for Combination Therapy.
Topics: Asthma; Chemistry, Pharmaceutical; Crystallization; Diabetes Mellitus; Drug Therapy, Combination; Fl | 2018 |
Impact of doxofylline compared to theophylline in asthma: A pooled analysis of functional and clinical outcomes from two multicentre, double-blind, randomized studies (DOROTHEO 1 and DOROTHEO 2).
Topics: Adult; Albuterol; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volu | 2018 |
Transcription inhibitors and inflammatory cell activity.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Humans; Inflammation; Pulmonary Di | 2019 |
Theophylline.
Topics: Asthma; Bronchodilator Agents; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline | 2013 |
[Update on current care guidelines: asthma].
Topics: Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Glucocorticoids; Hum | 2013 |
Advances in the diagnosis and management of asthma in older adults.
Topics: Administration, Inhalation; Age Factors; Age of Onset; Aged; Aging; Airway Resistance; Anti-Asthmati | 2014 |
[My research on asthma today and in the future].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; D | 2013 |
[Pregnancy and bronchial asthma].
Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Albuterol; Asthma; Bronchodilator A | 2014 |
Asthma and other recurrent wheezing disorders in children (acute).
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Asthma; Ch | 2012 |
Endocrine regulation of airway contractility is overlooked.
Topics: Adaptation, Physiological; Adiponectin; Androgens; Animals; Asthma; Bronchodilator Agents; Dehydroep | 2014 |
Management of allergy in the real world.
Topics: Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Antibodies, Monoclonal; Asthma; Humans | 2014 |
Interventions for managing asthma in pregnancy.
Topics: Adrenal Cortex Hormones; Algorithms; Anti-Asthmatic Agents; Asthma; Beclomethasone; Female; Humans; | 2014 |
Phosphodiesterase inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Bronchodilator Agents; Clinic | 2014 |
High-dose inhaled corticosteroids or addition of theophylline in patients with poorly controlled asthma?
Topics: Administration, Inhalation; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Dose-Response Rela | 2015 |
The potential of methylxanthine-based therapies in pediatric respiratory tract diseases.
Topics: Adolescent; Apnea; Asthma; Bronchodilator Agents; Caffeine; Child; Child, Preschool; Cough; Humans; | 2016 |
The Evidence for Intravenous Theophylline Levels between 10-20mg/L in Children Suffering an Acute Exacerbation of Asthma: A Systematic Review.
Topics: Acute Disease; Administration, Intravenous; Asthma; Bronchodilator Agents; Child; Humans; Practice G | 2016 |
Xanthines and Phosphodiesterase Inhibitors.
Topics: Animals; Asthma; Contraindications; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibi | 2017 |
What is new in the management of childhood asthma?
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Bronchodilator A | 2008 |
Differentiating chronic obstructive pulmonary disease from asthma.
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Causality; Cholin | 2008 |
Understanding clinical variability in response to asthma treatment.
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Child; Genetic Variation; Glucocorticoids; | 2009 |
Clinical practice. Asthma in pregnancy.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents | 2009 |
Asthma in adults.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Anti-Asthmatic Agents; Asthma; Humans; L | 2007 |
[Asthma therapy: combination of topical glucocorticosteroids and theophylline].
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Anti-Inflammatory Agents; Asthma; B | 1997 |
[Treatment of bronchial asthma in adults. Current advances].
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Antibodies, Anti | 2009 |
Common causes of uncommon seizures.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antiviral Agents; Asthma; Brain; Bronchiolitis; Child; | 2009 |
Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Databases, Bibliographic; Humans; Pulmonary Di | 2009 |
[Bronchial asthma in pregnant women].
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenergic Agonists; Asthma; Bronchodilator Agents; F | 2010 |
Asthma in pregnancy: pathophysiology, diagnosis and management.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Anti-Asthm | 2010 |
Methylxanthines in asthma.
Topics: Animals; Asthma; Humans; Lung; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; The | 2011 |
Addition of theophylline or increasing the dose of inhaled corticosteroid in symptomatic asthma: a meta-analysis of randomized controlled trials.
Topics: Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Forced Expiratory Volume; Humans; Randomized | 2011 |
[Bronchial asthma in children].
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Androstadi | 2011 |
Phosphodiesterase inhibitors: history of pharmacology.
Topics: Animals; Asthma; Bronchodilator Agents; Cardiovascular Diseases; Humans; Nitric Oxide; Phosphodieste | 2011 |
Asthma in adults.
Topics: Acute Disease; Administration, Inhalation; Adrenal Cortex Hormones; Adult; Anti-Asthmatic Agents; As | 2010 |
Asthma in adults.
Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; | 2011 |
Biochemical basis of asthma therapy.
Topics: Adrenergic beta-2 Receptor Agonists; Asthma; Cholinergic Antagonists; Glucocorticoids; Humans; Leuko | 2011 |
Asthma and other recurrent wheezing disorders in children (chronic).
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Anti-Asthmatic Agents; Asthma; Child; Humans; L | 2012 |
Chronotherapeutics--a chronopharmaceutical approach to drug delivery in the treatment of asthma.
Topics: Adrenergic beta-2 Receptor Antagonists; Anti-Asthmatic Agents; Asthma; Drug Chronotherapy; Glucocort | 2012 |
"CF asthma": what is it and what do we do about it?
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Bronchial Hyperreactivity; Bronchodila | 2002 |
Asthma in children.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asth | 2002 |
Clinical inquiries. Is there a role for theophylline in treating patients with asthma?
Topics: Adult; Age Factors; Asthma; Bronchodilator Agents; Child; Evidence-Based Medicine; Humans; Infusions | 2002 |
[Clinical guideline review: Bronchial asthma].
Topics: Adrenergic beta-Agonists; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Ast | 2002 |
Theophylline and PDE4 inhibitors in asthma.
Topics: Administration, Oral; Asthma; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; | 2003 |
Reassessment of theophylline use for severe asthma exacerbation: is it justified in critically ill hospitalized patients?
Topics: Asthma; Bronchodilator Agents; Critical Illness; Double-Blind Method; Hospitalization; Humans; Sever | 2002 |
Long-term management of asthma in children: effectiveness of inhaled corticosteroids compared to other medications.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents | 2002 |
Combination therapy: addition of other long-term-control medications to inhaled corticosteroids.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Asthmatic | 2002 |
[The effects of adenosine, interleukin-1 and theophylline on the expression of A2 adenosine receptor mRNAs in peripheral blood mononuclear cells from asthmatic patients].
Topics: Adenosine; Adolescent; Adult; Asthma; Female; Humans; Interleukin-1; Leukocytes, Mononuclear; Male; | 2001 |
Adenosine monophosphate bronchial provocation and the actions of asthma therapy.
Topics: Adenosine Monophosphate; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Inflammatory Agents; | 2003 |
Theophylline: new perspectives for an old drug.
Topics: Apoptosis; Asthma; Bronchodilator Agents; Gene Expression; Histone Deacetylases; Humans; Inflammatio | 2003 |
Anti-inflammatory treatment for recurrent wheezing in the first five years of life.
Topics: Anti-Inflammatory Agents; Asthma; Beclomethasone; Bronchodilator Agents; Budesonide; Child, Preschoo | 2003 |
[Asthma in the elderly].
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonist | 2003 |
Management of asthma in adults: current therapy and future directions.
Topics: Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Antagonists; Allergens; Anti-Asthmatic Agents; A | 2003 |
The case for a role for adenosine in asthma: almost convincing?
Topics: Adenosine; Adenosine Deaminase; Animals; Asthma; Asthma, Exercise-Induced; Bronchial Hyperreactivity | 2003 |
General strategy for the management of bronchial asthma in pregnancy.
Topics: Adrenergic beta-Agonists; Adult; Androstadienes; Anesthesia, Local; Anesthesia, Obstetrical; Asthma; | 2003 |
Pharmacology of airway inflammation in asthma and COPD.
Topics: Asthma; Bronchitis; Glucocorticoids; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline | 2003 |
Asthma in cystic fibrosis.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Bronchodilator Agents; Chi | 2003 |
Long acting beta-agonists versus theophylline for maintenance treatment of asthma.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchodilator Agents; Delayed-Action Preparatio | 2003 |
Treatment of childhood asthma: how do the available options compare?
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Asthma; Bronchodilator A | 2003 |
Theophylline: mechanism of action and use in asthma and chronic obstructive pulmonary disease.
Topics: Asthma; Clinical Trials as Topic; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline | 2004 |
[Recent study on pathogenesis of bronchial asthma and the therapeutic strategy].
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Anti-Asthmatic Agents; Anti-Inflamm | 2004 |
[Development of theophylline in treatment of asthma and chronic obstructive pulmonary disease].
Topics: Asthma; Bronchodilator Agents; Humans; Pulmonary Disease, Chronic Obstructive; Theophylline | 2004 |
Therapeutic responses in asthma and COPD. Bronchodilators.
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Cholinergic Antagonists; Dyspnea; Forced Ex | 2004 |
Asthma and other wheezing disorders of childhood.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Chi | 2003 |
Potential genetic influences on the response to asthma treatment.
Topics: Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Glucocorticoids; Humans; Leukotrienes; Phospho | 2004 |
[Current recommendation for asthma treatment].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Bronchodilator Age | 2004 |
[Treatment of bronchial asthma exacerbation].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Bronchodilator Age | 2004 |
NAEPP expert panel report. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update.
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Adult; Animals; Anti-Ast | 2005 |
Asthma and other wheezing disorders in infants and children.
Topics: Acetates; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Child; C | 2004 |
Asthma.
Topics: Acute Disease; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; Drug Therapy, Combina | 2004 |
[Bronchodilator: theophylline].
Topics: Aging; Asthma; Biomarkers; Bronchodilator Agents; Dosage Forms; Drug Interactions; Drug Monitoring; | 2004 |
Pharmacogenetic approaches in the treatment of asthma.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Arachidonate 5 | 2005 |
Asthma controller therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Ag | 2005 |
Histone acetylation and deacetylation: importance in inflammatory lung diseases.
Topics: Acetylation; Acetyltransferases; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Chromatin A | 2005 |
The management of asthma and rhinitis during pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Asthmati | 2005 |
Effects of dual therapy with corticosteroids plus long acting beta2-agonists in asthma.
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Drug Therapy, Combination; Glucocorticoi | 2005 |
The challenge of mild persistent asthma.
Topics: Adrenergic beta-Agonists; Adult; Aged; Anti-Asthmatic Agents; Asthma; Child; Clinical Trials as Topi | 2005 |
Blocking aspirin-induced bronchospasm.
Topics: Administration, Oral; Anti-Asthmatic Agents; Aspirin; Asthma; Bronchial Spasm; Drug Administration S | 2005 |
Oral xanthines as maintenance treatment for asthma in children.
Topics: Aminophylline; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Child; Humans; Randomized Contr | 2006 |
Safety of asthma and allergy medications in pregnancy.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Allergic Agents; Anti-Asthmatic Agents; Asth | 2006 |
Asthma and other wheezing disorders in children.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Child; Child, Pres | 2005 |
Asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asth | 2005 |
Investigation and treatment of asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Chronic Disease; H | 2005 |
Are phosphodiesterase 4 inhibitors just more theophylline?
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Asthma; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; P | 2006 |
[Update in asthma therapy. Slow-release theophylline].
Topics: Asthma; Autacoids; Humans; Theophylline | 2006 |
[Difficult asthma].
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspir | 2006 |
Histone deacetylation: an important mechanism in inflammatory lung diseases.
Topics: Acetylation; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Gene Expression; Glucocorticoi | 2005 |
Long-acting beta2-agonists versus theophylline for maintenance treatment of asthma.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchodilator Agents; Delayed-Action Preparatio | 2007 |
Asthma: guidelines-based control and management.
Topics: Asthma; Bronchodilator Agents; Drug Therapy; Guidelines as Topic; Humans; Psychometrics; Severity of | 2008 |
Doxofylline: The next generation methylxanthine.
Topics: Asthma; Bronchodilator Agents; Child; Humans; Theophylline | 2008 |
Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribing.
Topics: Adrenergic beta-Agonists; Aged; Asthma; Bronchodilator Agents; Cholinergic Antagonists; Drug Prescri | 2008 |
[Animal experiments and clinical studies on the role of adenosine in bronchial asthma].
Topics: Adenosine; Adult; Animals; Asthma; Atropine; Basophils; Bronchi; Bronchodilator Agents; Cromolyn Sod | 1984 |
In-vitro and in-vivo effects of theophylline and beta 2-adrenostimulants in combination.
Topics: Adrenergic beta-Agonists; Asthma; Bronchi; Drug Therapy, Combination; Humans; In Vitro Techniques; M | 1980 |
The management of chronic asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Allergens; Asthma; Child; Chronic Disease; Climat | 1980 |
Drugs affecting the respiratory system with particular reference to asthma.
Topics: Adrenergic alpha-Antagonists; Asthma; Asthma, Exercise-Induced; Bronchi; Child; Cromolyn Sodium; Cys | 1981 |
Strategies in the control of asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Allergens; Asthma; A | 1981 |
The evaluation, control, and modification of continuing asthma.
Topics: Adrenergic beta-Agonists; Asthma; Asthma, Exercise-Induced; Bronchi; Bronchial Provocation Tests; Hi | 1980 |
A critique of dosing strategies for beta-2 adrenergic agents and theophylline.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Bronchial Spasm; Bronchodilator Agents; Child; | 1981 |
The chronobiology and chronopharmacology of allergy.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Asthma; Biological Clocks; Bronchodilator Agen | 1981 |
The treatment of status asthmaticus.
Topics: Acute Disease; Adrenergic beta-Agonists; Airway Obstruction; Asthma; Blood Gas Analysis; Expectorant | 1981 |
Ketotifen in the oral prophylaxis of bronchial asthma: a review.
Topics: Asthma; Bronchi; Cromolyn Sodium; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Irrit | 1981 |
[Ketotifen in the prevention of bronchial asthma. International therapeutic evaluation].
Topics: Adrenal Cortex Hormones; Adult; Anaphylaxis; Asthma; Bronchial Provocation Tests; Bronchodilator Age | 1981 |
New drugs in respiratory disorders: I.
Topics: Adrenergic beta-Agonists; Aerosols; Asthma; Betamethasone; Bronchodilator Agents; Cromolyn Sodium; D | 1983 |
[Bronchial asthma. Long-term therapy and prognosis].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Child; Cromolyn Sodium; Dermatitis, Atopi | 1983 |
Current status of beta-adrenergic agonists in bronchial asthma.
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Child; Drug Synergism; Drug Tolerance; Huma | 1983 |
Exercise and asthma in athletes.
Topics: Adrenergic beta-Agonists; Asthma; Asthma, Exercise-Induced; Child; Cromolyn Sodium; Humans; Sports M | 1983 |
Special considerations in the approach to asthma in infancy and early childhood.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Air Pollutants; Allergens; Asthma; Bron | 1983 |
Therapeutic progress--review XI. Drugs in asthma.
Topics: Adrenergic beta-Agonists; Asthma; Calcium Channel Blockers; Cromolyn Sodium; Humans; Ipratropium; Ke | 1984 |
Airway smooth muscle, asthma, and calcium ions.
Topics: Asthma; Asthma, Exercise-Induced; Autacoids; Binding Sites; Calcium; Calcium Channel Blockers; Calmo | 1984 |
The chronic bronchitis complex in children.
Topics: Adrenergic beta-Agonists; Adult; Age Factors; Air Pollution; Anti-Bacterial Agents; Asthma; Bronchit | 1984 |
Antiasthmatic drugs.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Age Factors; Aminophylline; As | 1984 |
Ventilatory control in asthma.
Topics: Adrenergic beta-Agonists; Aminophylline; Analgesics; Asthma; Bronchial Provocation Tests; Carbon Dio | 1984 |
Pathophysiology and management of severe asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anesthesia, General; Anti-Infective Agents; Asthm | 1984 |
Theophylline use in asthma. Some current issues.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Asthma; Bronchi; Cardiac Output; Cyclic AMP; Drug Ther | 1984 |
Acute bronchial asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Aero | 1983 |
Postgraduate course presentation. Cromolyn sodium in the treatment of asthma: changing concepts.
Topics: Administration, Intranasal; Airway Obstruction; Animals; Asthma; Bronchial Spasm; Chemotactic Factor | 1981 |
Pharmacological modulation of mediator release: therapeutic significance?
Topics: Adrenergic beta-Agonists; Animals; Asthma; Bronchi; Cromolyn Sodium; Glucocorticoids; Histamine H1 A | 1983 |
Cromolyn.
Topics: Administration, Intranasal; Adult; Asthma; Asthma, Exercise-Induced; Child; Clinical Trials as Topic | 1983 |
Reciprocal relationship between pregnancy and pulmonary disease. State of the art.
Topics: Adrenergic beta-Agonists; Alcohol Drinking; Anti-Anxiety Agents; Anti-Bacterial Agents; Anti-Infecti | 1984 |
Theophylline therapy.
Topics: Asthma; Bronchodilator Agents; Delayed-Action Preparations; Humans; Theophylline | 1983 |
Single-entity sustained theophylline therapy for the pre-school child.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Administration Schedule; Humans; | 1983 |
Aminophylline.
Topics: Adult; Aminophylline; Anesthesia; Animals; Anticonvulsants; Arrhythmias, Cardiac; Asthma; Biotransfo | 1981 |
[Bronchodilators].
Topics: Animals; Asthma; Atropine Derivatives; Bronchodilator Agents; Clinical Trials as Topic; Drug Interac | 1984 |
A 25-year perspective of status asthmaticus.
Topics: Acidosis, Respiratory; Acute Disease; Adult; Asthma; Bicarbonates; Child; Dehydration; Epinephrine; | 1983 |
Metabolism and pharmacokinetics of theophylline in human neonates, children, and adults.
Topics: Adult; Age Factors; Apnea; Asthma; Biotransformation; Bradycardia; Caffeine; Child; Female; Half-Lif | 1983 |
Recent advances in respiratory medicine.
Topics: Adult; Aged; Anti-Bacterial Agents; Asthma; Bronchitis; Cephalosporins; Child; Humans; Immunosuppres | 1983 |
The profile of action of enprofylline, or why adenosine antagonism seems less desirable with xanthine antiasthmatics.
Topics: Adenosine; Animals; Asthma; Bronchi; Cats; Central Nervous System; Chemical Phenomena; Chemistry; Di | 1983 |
[Value of determining the serum theophylline level in the controlled treatment of bronchial asthma].
Topics: Asthma; Biological Availability; Chromatography, High Pressure Liquid; Half-Life; Humans; Immunoenzy | 1983 |
Role of patient compliance in the management of asthma.
Topics: Adolescent; Aerosols; Asthma; Child; Child, Preschool; Humans; Infant; Patient Compliance; Self Admi | 1983 |
Theophylline.
Topics: Adolescent; Adult; Asthma; Biological Availability; Child; Child, Preschool; Chromatography, High Pr | 1983 |
Therapy of chronic obstructive airways disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antitussive Agents; Asthma; Expectorants; Humans; Lu | 1984 |
The pharmacology and therapeutic use of theophylline.
Topics: Acute Disease; Adolescent; Adult; Apnea; Asthma; Bronchodilator Agents; Chemistry, Pharmaceutical; C | 1984 |
Bronchial asthma in adults: presentation to the emergency department. Part II: Sympathomimetics, respiratory failure, recommendations for initial treatment, indications for admission, and summary.
Topics: Adrenal Cortex Hormones; Albuterol; Aminophylline; Asthma; Emergencies; Epinephrine; Humans; Hydroge | 1983 |
The difficult asthmatic.
Topics: Asthma; Diabetes Complications; Diagnosis, Differential; Dyspnea, Paroxysmal; Female; Gastroesophage | 1984 |
Asthma and sports.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Breathing Exercises; Bronchial Provocation Tests; Child; Cr | 1983 |
Asthma in childhood.
Topics: Adolescent; Asthma; Beclomethasone; Behavior Therapy; Child; Child, Preschool; Cromolyn Sodium; Epin | 1983 |
Response: asthma in childhood.
Topics: Administration, Oral; Adrenal Cortex Hormones; Aerosols; Albuterol; Asthma; Bronchodilator Agents; C | 1983 |
Theophylline for chronic asthma: rationale for treatment, product selection, and dosage schedule.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Asthma; Child; Child, Preschool; Chronic Disease; Cromol | 1983 |
Asthma, or variable obstructive intrabronchial disease (VOID): an in depth review.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Cromolyn Sodium; Humans; Respiratory Functio | 1984 |
Clinical pharmacology of theophylline in children.
Topics: Adolescent; Adult; Age Factors; Asthma; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Ki | 1984 |
Choice of drug treatment in asthma.
Topics: Adrenal Cortex Hormones; Aerosols; Asthma; Bronchodilator Agents; Humans; Theophylline | 1982 |
Improved efficacy and safety of theophylline in the control of airways hyperreactivity.
Topics: Airway Resistance; Asthma; Biopharmaceutics; Chemical Phenomena; Chemistry; Humans; Intestinal Absor | 1982 |
Monitoring plasma theophylline concentrations.
Topics: Aging; Asthma; Humans; Kinetics; Theophylline | 1980 |
The relative merits of cromolyn sodium and high-dose theophylline therapy in childhood asthma.
Topics: Asthma; Asthma, Exercise-Induced; Child; Child, Preschool; Cromolyn Sodium; Dose-Response Relationsh | 1980 |
Corticosteroids in asthma: inhaled or oral?
Topics: Administration, Oral; Aerosols; Asthma; Beclomethasone; Cortisone; Cromolyn Sodium; Drug Administrat | 1980 |
Experience with theophylline for the management of chronic asthma.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Child; Chronic Disease; Cromolyn Sodium; Hum | 1980 |
Pharmacologic management of reversible obstructive airways disease.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Cromolyn Sodium; Humans; Lung Diseases, Obst | 1981 |
Some pharmacological aspects of xanthines in asthma.
Topics: Asthma; Histamine; Humans; Lung; Pulmonary Edema; Respiratory System; Theophylline; Xanthines | 1980 |
Two new roles for theophylline in the asthmatic?
Topics: Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Humans; Muscle Fatigue; Respiratory Muscles | 1995 |
Behavioral side effects of medications used to treat asthma and allergic rhinitis.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Atropine; Child; Child, Presc | 1995 |
Theophylline and selective phosphodiesterase inhibitors as anti-inflammatory drugs in the treatment of bronchial asthma.
Topics: Animals; Anti-Inflammatory Agents; Asthma; Guinea Pigs; Humans; Phosphodiesterase Inhibitors; Theoph | 1995 |
PDE isoenzymes as targets for anti-asthma drugs.
Topics: Anti-Asthmatic Agents; Asthma; Humans; Isoenzymes; Phosphodiesterase Inhibitors; Phosphoric Diester | 1995 |
Evolving role of theophylline for treatment of chronic childhood asthma.
Topics: Adrenergic beta-Agonists; Asthma; Beclomethasone; Bronchodilator Agents; Child; Clinical Trials as T | 1995 |
[Asthma and its treatment during pregnancy].
Topics: Adrenal Cortex Hormones; Asthma; Female; Fetal Hypoxia; Humans; Infant, Newborn; Pregnancy; Pregnanc | 1995 |
[Severe acute asthma].
Topics: Acute Disease; Anti-Inflammatory Agents; Asthma; Humans; Oxygen; Syndrome; Theophylline | 1995 |
Clinical management strategies to maintain drug compliance in asthmatic children.
Topics: Asthma; Child; Drug Monitoring; Humans; Male; Patient Compliance; Theophylline | 1995 |
[Theophylline in the treatment of asthma: is it still relevant?].
Topics: Asthma; Humans; Theophylline | 1995 |
Theophylline.
Topics: Asthma; Calcium; Cyclic AMP; Humans; Muscle, Smooth; Platelet Aggregation; Platelet Aggregation Inhi | 1995 |
ABC of asthma. Chronic asthma--general management.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Clinical Protoco | 1995 |
Cyclic nucleotides and phosphodiesterases and airway function.
Topics: Animals; Asthma; Cyclic AMP; Cyclic GMP; Humans; Isoenzymes; Muscle, Smooth; Phosphodiesterase Inhib | 1995 |
Severe bronchial asthma improved on bamifylline. Case report and review.
Topics: Adult; Asthma; Bronchodilator Agents; Humans; Male; Theophylline | 1994 |
[Theophylline: new information about a proven drug. The dual effect in therapy of bronchial asthma].
Topics: Airway Resistance; Asthma; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Ther | 1994 |
Theophylline in childhood asthma.
Topics: Asthma; Child; Humans; Theophylline | 1994 |
[Acute asthma therapy: inhalation therapy better than intravenous therapy].
Topics: Acute Disease; Adrenergic beta-Agonists; Asthma; Humans; Infusions, Intravenous; Respiratory Therapy | 1993 |
Pharmacokinetic optimisation of asthma treatment.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Asthma; Bio | 1994 |
New trends in asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Cromolyn Sodium; D | 1993 |
Theophylline in the management of asthma: time for reappraisal?
Topics: Animals; Asthma; Bronchodilator Agents; Humans; Theophylline | 1994 |
Neuropsychological dysfunction in asthmatic children.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Central Nervous System; Child; C | 1994 |
A review of some recent clinical studies with nedocromil sodium.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Inflammatory Age | 1993 |
Advances in respiratory therapeutics in children.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Bronchiolitis, | 1993 |
Asthma, inflammation, and airway hyperresponsiveness in children.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Allergens; Anti-Inflammatory Agents; Asthma; Bron | 1993 |
[What is assured in drug therapy of bronchial asthma?].
Topics: Airway Resistance; Asthma; Bronchodilator Agents; Cromolyn Sodium; Drug Therapy, Combination; Glucoc | 1993 |
The changing role of theophylline in pediatric asthma.
Topics: Asthma; Child; Child Behavior; Humans; Theophylline | 1994 |
The chronopharmacological application of theophylline therapy in asthma.
Topics: Asthma; Delayed-Action Preparations; Humans; Theophylline | 1994 |
Cyclic nucleotide phosphodiesterases in the human lung.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Asthma; Hemodynamics; Humans; Hypertension, | 1994 |
[Treatment strategy in childhood bronchial asthma].
Topics: Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Child; Child, Preschool; Dose-Response Rela | 1993 |
Theophylline. Current thoughts on the risks and benefits of its use in asthma.
Topics: Asthma; Humans; Risk Factors; Theophylline | 1993 |
Current issues in the use of theophylline.
Topics: Asthma; Humans; Theophylline | 1993 |
[Two cases of theophylline-associated encephalopathy in childhood: clinical and CT findings].
Topics: Asthma; Brain; Brain Diseases; Child, Preschool; Humans; Injections, Intravenous; Male; Theophylline | 1993 |
Molecular mechanisms of antiasthma therapy.
Topics: Adrenergic beta-Agonists; Asthma; Glucocorticoids; Humans; Theophylline; Transcription Factors | 1995 |
[Chronopharmacology of reversible airway obstruction].
Topics: Adrenergic beta-Agonists; Airway Obstruction; Airway Resistance; Anti-Asthmatic Agents; Anti-Inflamm | 1995 |
Theophylline in asthma.
Topics: Asthma; Humans; Theophylline | 1996 |
[Recent view on drug therapy of bronchial asthma].
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Beclomethasone; Betamethasone; Bronchodi | 1996 |
The role of theophylline in the treatment of asthma.
Topics: Asthma; Humans; Theophylline | 1996 |
[Guidelines for the treatment of asthma].
Topics: Administration, Inhalation; Anti-Inflammatory Agents; Asthma; Humans; Patient Education as Topic; Pr | 1996 |
Asthma: an important disease to otolaryngologists--Part II: Asthma management strategy.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Asthma; Cholinergic Antagonists; Expectorants | 1996 |
Problem drugs for the patient with asthma.
Topics: Adrenergic beta-Antagonists; Anaphylaxis; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammator | 1996 |
Asthma: the disease and its management.
Topics: Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Diagnosis, Differential; Humans; Immunother | 1996 |
[Myoglobinuria following anesthesia with enflurane and succinylcholine in an asthmatic child on theophylline].
Topics: Anesthesia, Inhalation; Asthma; Bronchodilator Agents; Child; Enflurane; Humans; Male; Muscle Rigidi | 1996 |
Immunomodulation as asthma therapy: where do we stand?
Topics: Adjuvants, Immunologic; Administration, Inhalation; Adrenal Cortex Hormones; Anti-Asthmatic Agents; | 1996 |
Low-dose theophylline: a new anti-inflammatory role in asthma management?
Topics: Asthma; Bronchodilator Agents; Cytokines; Dose-Response Relationship, Drug; Eosinophils; Humans; T-L | 1996 |
[The brittle asthmatic and the morning dipper].
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Chromones; Circad | 1996 |
[Chronopharmacology and chronotherapy for asthma by using PEF].
Topics: Administration, Oral; Adult; Aged; Asthma; Bronchodilator Agents; Chronotherapy; Circadian Rhythm; D | 1996 |
[Inhaled beta agonists as a bronchodilator are a mainstay of asthma therapy: focusing on inhaled beta agonists and oral theophylline].
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Asthma; Bronchodilator A | 1996 |
[The development of slow-release theophylline products and revaluation of theophylline's role as a bronchodilator].
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Controlled Clinic | 1996 |
[Slow-release theophylline for the treatment of asthmatic children].
Topics: Adolescent; Anti-Inflammatory Agents; Asthma; Biological Availability; Bronchodilator Agents; Child; | 1996 |
[The clinical application of long-acting preparations of theophylline].
Topics: Asthma; Bronchodilator Agents; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparatio | 1996 |
Theophylline in chronic asthma--evidence for disease-modifying properties.
Topics: Adult; Aged; Animals; Asthma; Chronic Disease; Female; Humans; Male; Middle Aged; Theophylline | 1996 |
The role of theophylline in the management of chronic asthma in adults.
Topics: Adult; Asthma; Chronic Disease; Humans; Theophylline | 1996 |
Theophylline in the treatment of asthma.
Topics: Asthma; Humans; Theophylline | 1996 |
Current therapies for asthma. Promise and limitations.
Topics: Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Chromones; Glucocort | 1997 |
Theophylline in acute childhood asthma: a meta-analysis of its efficacy.
Topics: Acute Disease; Adolescent; Asthma; Bronchodilator Agents; Child; Child, Preschool; Hospitalization; | 1996 |
Bronchodilators: new drugs and controversies.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Asthma; Asthma, Exercise-Induced; Bron | 1997 |
Are you "missing the boat" in modern asthma therapy?
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Humans; Patient | 1997 |
Evidence for benefits of early intervention with non-steroidal drugs in asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Inflammat | 1997 |
New developments in bronchodilator therapy.
Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; | 1996 |
Emergency treatment of asthma.
Topics: Acute Disease; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Airway | 1996 |
[Immunomodulatory properties of subtherapeutic levels of theophylline].
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Antigens, CD; Asthma; CD4-CD8 Ratio; Forc | 1997 |
Treatment of childhood asthma. Options and rationale for inhaled therapy.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Age Factors; Anti-Ast | 1998 |
Theophylline: recent advances in the understanding of its mode of action and uses in clinical practice.
Topics: Apnea; Apoptosis; Asthma; Calcium Channels; Capillary Leak Syndrome; Catecholamines; Erythropoietin; | 1998 |
[Current status on the treatment of asthma--special reference to anti-inflammatory drug therapy].
Topics: Administration, Inhalation; Anti-Allergic Agents; Anti-Inflammatory Agents; Asthma; Beclomethasone; | 1998 |
[Theophylline--anti-inflammatory drug].
Topics: Animals; Anti-Inflammatory Agents; Asthma; Biopsy; Bronchi; Bronchoalveolar Lavage Fluid; CD4 Lympho | 1998 |
The efficacy and safety of salmeterol compared to theophylline: meta-analysis of nine controlled studies.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Bronchodilator Agents; Chronic Disease; Fe | 1998 |
Asthma therapy for the 21st century.
Topics: Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Cell Adhesion Molecu | 1998 |
[Theophylline in treatment of bronchial obstructive diseases].
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Asthma; Bronchial Diseases; Bronchial Spasm; Bronc | 1998 |
The role of theophylline and phosphodiesterase4 isoenzyme inhibitors as anti-inflammatory drugs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents; Asthma; Cyclic Nucleotide Ph | 1998 |
Theophylline and airway inflammation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine; Administration, Oral; Anti-Inflammatory Agents; Asth | 1998 |
Asthma, adenosine, mast cells and theophylline.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Asthma; Cytokines; Humans; Immunohistochemistry; Lung; | 1998 |
Nocturnal asthma and the use of theophylline.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; | 1998 |
Theophylline. A review of its potential steroid sparing effects in asthma.
Topics: Adrenal Cortex Hormones; Asthma; Biological Availability; Bronchodilator Agents; Dose-Response Relat | 1998 |
Fortnightly review: modern drug treatment of chronic asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Asthma; Dose-Response R | 1999 |
Recent advances in our understanding of the use of theophylline in the treatment of asthma.
Topics: Asthma; Bronchodilator Agents; Humans; Theophylline | 1999 |
Adenosine receptor ligands: potential as therapeutic agents in asthma and COPD.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Humans; Ligands; Lung Diseases, Obstr | 1999 |
Advances in pharmacotherapy of asthma.
Topics: Administration, Intranasal; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Asthmatic | 1999 |
[Diagnosis and management of asthma].
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Anti-Inflammatory Agents | 1999 |
Circadian rhythms in the pharmacokinetics and clinical effects of beta-agonist, theophylline, and anticholinergic medications in the treatment of nocturnal asthma.
Topics: Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Cholinergic Antagoni | 1999 |
The problems of treating adolescent asthma: what are the alternatives to inhaled therapy?
Topics: Administration, Oral; Adolescent; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Histamine H1 | 1999 |
Management of respiratory failure in patients with asthma.
Topics: Administration, Inhalation; Albuterol; Asthma; Bronchodilator Agents; Calcium Channel Blockers; Gluc | 2000 |
Corticosteroid-sparing options in the treatment of childhood asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Bone and Bones; Ch | 2000 |
Long acting beta-agonists versus theophylline for maintenance treatment of asthma.
Topics: Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchodilator Agents; Delayed-Action Preparatio | 2000 |
The role of theophylline in asthma management.
Topics: Asthma; Bronchodilator Agents; Drug Therapy, Combination; Humans; Theophylline | 1999 |
Phosphodiesterase 4 inhibitors, structurally unrelated to rolipram, as promising agents for the treatment of asthma and other pathologies.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Arthritis, Rheumatoid; Asthma; Cyclic Nucleotide Phosphodiester | 2000 |
Treatment of acute asthma. A new look at the old and at the new.
Topics: Adrenergic beta-Agonists; Adult; Aminophylline; Asthma; Bronchodilator Agents; Child; Cholinergic An | 2000 |
A review of clinical use of theophylline in acute asthma: factors influencing kinetic disposition and drug interactions.
Topics: Acute Disease; Adult; Age Factors; Aged; Asthma; Child, Preschool; Drug Interactions; Humans; Infant | 2000 |
Asthma: the new advances.
Topics: Acetates; Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Child; Cyclopropanes; Gl | 2000 |
Challenges in evaluating controller asthma therapy in children.
Topics: Adrenal Cortex Hormones; Asthma; Child; Child, Preschool; Drug Evaluation; Humans; Theophylline | 2000 |
Theophylline for the treatment of bronchial asthma: present status.
Topics: Animals; Asthma; Bronchodilator Agents; Humans; Theophylline | 2000 |
[Undesirable pharmacokinetic interactions of theophylline].
Topics: Apoptosis; Asthma; Cyclic AMP; Drug Interactions; Humans; Muscle, Skeletal; Receptors, Purinergic P1 | 2000 |
Asthma in pregnancy.
Topics: Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchodilator Ag | 2000 |
[Theophylline].
Topics: Asthma; Bronchodilator Agents; Humans; Theophylline | 2000 |
[Pediatric allergy].
Topics: Anti-Allergic Agents; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Child; Desensitizatio | 2000 |
Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects.
Topics: Animals; Arrhythmias, Cardiac; Asthma; Bronchodilator Agents; Cardiovascular Diseases; Drug Evaluati | 2001 |
[Aspirin-induced asthma].
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Cyclooxygenase I | 2000 |
[Theophylline--mechanism of action in the respiratory tract].
Topics: Anti-Inflammatory Agents; Asthma; Bronchi; Diaphragm; Humans; Lung; Lung Diseases, Obstructive; Musc | 2000 |
Gender-specific prescribing: medications and the menstrual cycle.
Topics: Adolescent; Adult; Anticonvulsants; Asthma; Bronchodilator Agents; Epilepsy; Female; Humans; Menstru | 1998 |
Nocturnal asthma uncontrolled by inhaled corticosteroids: theophylline or long-acting beta2 agonists?
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Circadian Rhy | 2001 |
Chemotaxis of human CD4+ eosinophils.
Topics: Asthma; CD4 Antigens; Chemotaxis, Leukocyte; Dexamethasone; Eosinophils; Humans; Interleukin-16; Mod | 2001 |
The efficacy and safety of asthma medications during pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agent | 2001 |
The use of sputum cell counts to evaluate asthma medications.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Inflammatory Agents; | 2001 |
Should we still be using theophylline to treat asthma?
Topics: Asthma; Bronchodilator Agents; Humans; Theophylline | 2001 |
[Recent advance in inhaled corticosteroid therapy].
Topics: Administration, Inhalation; Administration, Topical; Adrenergic beta-Agonists; Androstadienes; Anti- | 2001 |
Recent developments in the genetics of asthma.
Topics: Adrenergic beta-Agonists; Anti-Asthmatic Agents; Arachidonate 5-Lipoxygenase; Asthma; Cholinergic An | 2001 |
Balancing safety and efficacy in pediatric asthma management.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents | 2002 |
[Apoptosis and inflammation in bronchial asthma].
Topics: Anti-Inflammatory Agents; Apoptosis; Asthma; Bronchodilator Agents; Eosinophils; fas Receptor; Gluco | 2001 |
[What is reliable in the therapy of the bronchial asthma?].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Asthma; Atropine Derivatives; Bronchodi | 1975 |
[Drug therapy of bronchial asthma].
Topics: Adrenocorticotropic Hormone; Adult; Asthma; Atropine; Beclomethasone; Child; Cromolyn Sodium; Epinep | 1975 |
Treatment of asthma with theophylline and beta adrenergic agents.
Topics: Adrenergic beta-Agonists; Adult; Asthma; Chemical Phenomena; Chemistry; Child; Humans; Receptors, Ad | 1976 |
Newer medications to aid treatment of asthma.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminophylline; Asthma; | 1977 |
Drugs in the treatment of asthma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenocorticotropic Hormone; Animals; Asthma; C | 1978 |
[New aspects of long-term asthma therapy].
Topics: Adrenergic beta-Agonists; Adrenocorticotropic Hormone; Allergens; Asthma; Chronic Disease; Cromolyn | 1979 |
[New viewpoints in the pathogenesis and therapy of bronchial asthma].
Topics: Acetylcholine; Adrenergic beta-Agonists; Analgesics; Asthma; Atropine; Bacterial Infections; Bronchi | 1979 |
An evaluation of pharmacotherapy for exercise-induced asthma.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adult; Aerosols; Asthm | 1979 |
Airway pharmacology.
Topics: Adrenergic beta-Agonists; Airway Resistance; Asthma; Autonomic Nervous System; Bronchi; Glucocortico | 1979 |
[Pulmonary function tests with the bronchodilator Terbutaline].
Topics: Administration, Oral; Adult; Aged; Albuterol; Asthma; Atropine; Clenbuterol; Epinephrine; Female; Fe | 1979 |
New drug therapy for asthma.
Topics: Asthma; Atropine; Beclomethasone; Cromolyn Sodium; Humans; Isoproterenol; Metaproterenol; Receptors, | 1978 |
Theophylline derivatives: a current review.
Topics: Administration, Oral; Aminophylline; Asthma; Drug Therapy, Combination; Humans; Injections, Intraven | 1977 |
[Theophylline in childhood asthmatic syndromes].
Topics: Asthma; Biological Availability; Child; Humans; Kinetics; Theophylline | 1979 |
On the action of combination bronchodilators.
Topics: Albuterol; Animals; Asthma; Bronchodilator Agents; Dogs; Drug Combinations; Drug Synergism; Ephedrin | 1979 |
Bronchodilator therapy (second of two parts).
Topics: Adrenal Cortex Hormones; Asthma; Bronchial Spasm; Bronchodilator Agents; Cromolyn Sodium; Drug Thera | 1977 |
Asthma: therapy old and new.
Topics: Asthma; Beclomethasone; Bronchi; Cromolyn Sodium; Glucocorticoids; Humans; Parasympatholytics; Sympa | 1977 |
Inhibition of exercise-induced asthma by different pharmacological pathways.
Topics: Adolescent; Airway Obstruction; Albuterol; Asthma; Atropine Derivatives; Bronchodilator Agents; Chil | 1976 |
Pharmacotherapy of asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Asthma; Child; Chronic Disease; Cromolyn Sodium; Humans; Sym | 1976 |
Pharmacotherapy of asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Chronic Disease; Cromolyn Sod | 1976 |
Current status of the use of theophyllines in children.
Topics: Administration, Oral; Asthma; Child; Humans; Injections, Intravenous; Theophylline | 1975 |
Use of ephedrine in bronchodilator therapy.
Topics: Asthma; Bronchi; Central Nervous System Diseases; Drug Therapy, Combination; Ephedrine; Gastrointest | 1975 |
[Review of North American studies on nedocromil sodium].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Clinical Trials as Topic; | 1992 |
Basic pharmacotherapy for asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Clinical Protocols; Cromolyn Sodium; Drug | 1992 |
The emergent approach to asthma.
Topics: Adrenergic beta-Agonists; Asthma; Blood Gas Analysis; Clinical Protocols; Decision Making; Emergency | 1992 |
Anti-inflammatory drugs in the treatment of allergic disease.
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Auranofin; Bronchodilator Agents; Cromol | 1992 |
Asthma. Bronchodilators: new developments.
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Fenoterol; Humans; Parasympatholytics; Theo | 1992 |
New drugs for asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Bronchodilator | 1992 |
Asthma in the 1990s. A new approach to therapy.
Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; | 1992 |
[Treatment of early-stage asthma].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Combined Modality Therapy; Cromolyn Sodiu | 1992 |
A step-wise approach to the changing drug therapy of asthma.
Topics: Adrenal Insufficiency; Adult; Anti-Inflammatory Agents; Asthma; Child; Cromolyn Sodium; Humans; Infl | 1992 |
Nocturnal asthma.
Topics: Adrenal Cortex Hormones; Asthma; Bronchial Hyperreactivity; Circadian Rhythm; Gastroesophageal Reflu | 1992 |
[The treatment of early asthma].
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Bronchodilator Agents; Child; Cr | 1992 |
The theophylline dilemma.
Topics: Administration, Oral; Adult; Aged; Asthma; Bronchitis; Delayed-Action Preparations; Female; Humans; | 1992 |
[Anti-asthmatic agents. From pharmacology to clinical aspects].
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Cromolyn Sodium; Glucocorticoids; Humans; K | 1991 |
Paediatric asthma, prospects for control or cure.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Inflammatory Agents, Non-Steroidal; Asthma; | 1991 |
Treatment of asthma in children.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; B | 1991 |
[Chronotherapy of asthma].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchoconstriction; Bronchodilator Agent | 1991 |
Asthma--something old, something new ....
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Eosinophils; Humans; Inflammation; Interl | 1991 |
Safety and efficacy of theophylline in children with asthma.
Topics: Asthma; Child; Drug Interactions; Humans; Theophylline | 1992 |
[A case of theophylline-induced rhabdomyolysis following therapy of bronchial asthma].
Topics: Aged; Aged, 80 and over; Asthma; Humans; Male; Rhabdomyolysis; Theophylline | 1991 |
Nocturnal asthma: mechanisms and the role of theophylline in treatment.
Topics: Asthma; Bronchial Hyperreactivity; Circadian Rhythm; Humans; Lung; Theophylline | 1991 |
[Clinical pharmacology in optimization of therapy of lung diseases].
Topics: Antitubercular Agents; Asthma; Biotransformation; Ethionamide; Humans; Isoniazid; Metabolic Clearanc | 1991 |
Respiratory muscle function in asthma.
Topics: Adrenal Cortex Hormones; Asthma; Humans; Positive-Pressure Respiration; Respiration, Artificial; Res | 1991 |
Theophylline in asthma management: current controversy.
Topics: Asthma; Humans; Theophylline | 1991 |
[Day-night pattern of bronchial width and dyspnea: basis for selection of optimal dosage schedules for theophylline].
Topics: Asthma; Bronchi; Circadian Rhythm; Drug Administration Schedule; Dyspnea; Humans; Theophylline | 1991 |
[Recent acquisitions on the pharmacology and therapeutic uses of theophylline with special reference to cardiovascular effects].
Topics: Adult; Angina Pectoris; Apnea; Asthma; Cardiovascular System; Child; Female; Humans; Infant, Newborn | 1991 |
[Current concepts of asthma in children].
Topics: Adrenal Cortex Hormones; Asthma; Child; Child, Preschool; Combined Modality Therapy; Diagnosis, Diff | 1990 |
Pharmacology of airway inflammation in asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Airway Resistance; Anti-Inflammatory Agents; Asth | 1990 |
Asthma in primary care patients. Challenges and controversies.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Allergens; Asthma; Combined Modality Therapy; Cro | 1990 |
[Current concepts in the treatment of asthma (in the United States)].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Albuterol; Asthma; Bronchial Spasm; Costs and | 1990 |
[Asthma and gastroesophageal reflux. Outcome of asthma after longterm medical treatment of the reflux].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Child; Child, Preschool; Cimetidine; E | 1990 |
[Adverse drug effects in bronchial asthma].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Female; Humans; Ma | 1990 |
[Role of beta-2-mimetic agents in the treatment of asthma].
Topics: Administration, Oral; Adrenergic beta-Agonists; Aerosols; Asthma; Bronchodilator Agents; Circadian R | 1990 |
Theophylline in asthma and COPD: changing perspectives and controversies.
Topics: Asthma; Humans; Lung Diseases, Obstructive; Mucociliary Clearance; Theophylline | 1991 |
[Individually-adjusted dosages of aminophylline in children with bronchial asthma].
Topics: Adolescent; Aminophylline; Asthma; Child; Half-Life; Humans; Theophylline | 1990 |
Management of chronic airway obstruction: theophylline--is it still necessary?
Topics: Airway Resistance; Asthma; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Respiratory | 1990 |
Management of asthma and chronic airflow limitation: are methylxanthines obsolete?
Topics: Adrenal Cortex Hormones; Airway Resistance; Aminophylline; Asthma; Bronchodilator Agents; Drug Thera | 1990 |
Theophylline in the management of airflow obstruction. 1. Much evidence suggests that theophylline is valuable.
Topics: Asthma; Humans; Lung Diseases, Obstructive; Theophylline | 1990 |
Theophylline in the management of airflow obstruction. 2. Difficult drugs to use, few clinical indications.
Topics: Acute Disease; Adult; Asthma; Child, Preschool; Chronic Disease; Humans; Lung Diseases, Obstructive; | 1990 |
The relationship between vitamin B6 metabolism, asthma, and theophylline therapy.
Topics: Asthma; Humans; Pyridoxal Kinase; Pyridoxal Phosphate; Pyridoxine; Theophylline; Vitamin B 6 Deficie | 1990 |
Management of asthma and chronic airflow limitation. Are methylxanthines obsolete?
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Aminophylline; Asthma; Bronchodilator Agents; H | 1990 |
Acute care of mild to moderately severe asthma in 1990.
Topics: Acute Disease; Adrenal Cortex Hormones; Aerosols; Asthma; Emergency Medical Services; Epinephrine; H | 1990 |
[Serum concentration and clinical efficacy of drugs in pulmonary and cardiac disease].
Topics: Administration, Oral; Adult; Aged; Asthma; Cardiac Complexes, Premature; Chromatography, High Pressu | 1985 |
Antiasthmatic therapy in children.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Child; Cromolyn Sodium; Delivery of Health C | 1989 |
Therapy of asthma in children.
Topics: Asthma; Child; Child, Preschool; Cromolyn Sodium; Family; Humans; Infant; Patient Education as Topic | 1989 |
[Problems of respiratory drug therapy in pregnancy].
Topics: Adrenal Cortex Hormones; Aminophylline; Anti-Bacterial Agents; Antitubercular Agents; Asthma; Cromol | 1989 |
Reassessment of mast cell stabilizers in the treatment of respiratory disease.
Topics: Adrenal Cortex Hormones; Adult; Animals; Asthma; Child; Clinical Trials as Topic; Cromolyn Sodium; H | 1989 |
Round table on antiasthmatic drugs; beta-agonists and theophylline. Workshop on pathogenesis and therapy of bronchial asthma Cortina d'Ampezzo/1-4 April, 1987.
Topics: Adrenergic beta-Agonists; Asthma; Cardiovascular System; Humans; Metabolism; Theophylline | 1989 |
[Combination of theophylline and beta-adrenergic agonists in the treatment of asthma: efficacy and tolerance. Review of the literature].
Topics: Acute Disease; Adrenergic beta-Agonists; Arrhythmias, Cardiac; Asthma; Bronchi; Drug Therapy, Combin | 1989 |
[Beta-2 adrenergic stimulants in the treatment of asthma: myths and realities].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Asthma; Drug Tolerance; Humans; Parasym | 1989 |
New aspects of the therapeutic potential of theophylline in asthma.
Topics: Asthma; Humans; Theophylline | 1989 |
Methylxanthines in 1989.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Humans; Sympatho | 1989 |
Childhood asthma: management.
Topics: Adrenal Cortex Hormones; Asthma; Child; Child, Preschool; Humans; Immunotherapy; Theophylline | 1989 |
Chronopharmacology and its application to the development of theophylline treatment schedules for asthma.
Topics: Asthma; Circadian Rhythm; Humans; Theophylline | 1989 |
The value of theophylline for asthma.
Topics: Asthma; Humans; Theophylline | 1989 |
Is theophylline use justified in acute exacerbations of asthma?
Topics: Acute Disease; Asthma; Emergency Medical Services; Hospitalization; Humans; Lung Volume Measurements | 1989 |
Psychological problems associated with drug therapy in childhood asthma.
Topics: Asthma; Attention Deficit Disorder with Hyperactivity; Central Nervous System; Child; Humans; Learni | 1989 |
[Treatment of the severe asthma attack and status asthmaticus].
Topics: Airway Resistance; Albuterol; Asthma; Drug Therapy, Combination; Fenoterol; Humans; Prednisolone; St | 1989 |
[Hemosorption in the treatment of bronchial asthma].
Topics: Asthma; Follow-Up Studies; Glucocorticoids; Hemoperfusion; Humans; Immunoglobulins; T-Lymphocytes; T | 1989 |
Management of acute severe asthma.
Topics: Acute Disease; Asthma; Child; Child, Hospitalized; Emergencies; Glucocorticoids; Humans; Parasympath | 1989 |
Therapeutic monitoring of theophylline. Rationale and current status.
Topics: Adult; Asthma; Child, Preschool; Humans; Monitoring, Physiologic; Theophylline | 1989 |
Should we stop using theophylline for the treatment of the hospitalized patient with status asthmaticus?
Topics: Asthma; Hospitalization; Humans; Status Asthmaticus; Theophylline | 1989 |
Anti-allergy and anti-asthma drugs. Disposition in infancy and childhood.
Topics: Adolescent; Asthma; Child; Child, Preschool; Humans; Hypersensitivity; Infant; Theophylline | 1989 |
[Theophylline in the treatment of asthma: indications, use and side effects].
Topics: Asthma; Delayed-Action Preparations; Dose-Response Relationship, Drug; Humans; Lung Diseases, Obstru | 1989 |
Bronchodilators in asthma.
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Humans; Parasympatholytics; Theophylline | 1985 |
Tulobuterol in the management of obstructive airways disease in adults.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Aged; Asthma; Bronchodilator Agents; Femal | 1985 |
Anaesthetic implications of calcium channel blockers.
Topics: Adrenergic beta-Antagonists; Anesthesia; Anesthetics; Animals; Asthma; Calcium; Calcium Channel Bloc | 1985 |
Asthma in infants and children--treatment of childhood asthma: Part II.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Insufficiency; Adrenergic beta-Agonists; Adult; Aerosol | 1985 |
Respiratory complications of gastroesophageal reflux.
Topics: Adrenergic beta-Agonists; Adult; Asthma; Child; Child, Preschool; Esophagogastric Junction; Gastroes | 1985 |
Physiologic changes that occur in response to allergen induced challenge.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aerosols; Allergens; | 1985 |
The treatment of asthma. Part 1. Pharmacology of therapeutic agents.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Asthma; Bronchodi | 1985 |
Current concepts in clinical therapeutics: asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Chemical Phenomena; Chemistry; Cromolyn S | 1986 |
Adrenergic therapy of bronchial asthma.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Aerosols; Asthma; Baso | 1986 |
Asthma therapy: basic mechanisms.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Animals; Annexins; Asthma; Calcium; Capillary Per | 1986 |
Why are deaths from asthma increasing?
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Canada; Child; Child, | 1986 |
Overview of effects of theophylline.
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Brain; Bronchi; Esophagus; Humans; Kidne | 1986 |
Adverse effects of theophylline-beta agonist interactions.
Topics: Adrenergic beta-Agonists; Animals; Asthma; Drug Interactions; Drug Therapy, Combination; Heart; Huma | 1986 |
The effect of theophylline and beta 2 agonists on airway reactivity.
Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Test | 1987 |
Theophylline as a bronchodilator in COPD and its combination with inhaled beta-adrenergic drugs.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchi; Bronchitis; Clinical Trials as Topic; | 1987 |
Bronchial asthma. Mechanisms and management of a complex obstructive airway disease.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Asthma; Bronchial Provocation Tests; Cr | 1987 |
Pharmacotherapy of allergic disease.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Aged; Anaphylax | 1987 |
Respiratory and allergic disease. I.
Topics: Asthma; Bronchodilator Agents; Delayed-Action Preparations; Histamine H1 Antagonists; Humans; Nedocr | 1988 |
[Pregnancy and asthma].
Topics: Adrenergic beta-Antagonists; Asthma; Bronchodilator Agents; Female; Fetus; Hematopoiesis; Hormones; | 1988 |
[Treatment of childhood asthma].
Topics: Adrenergic beta-Antagonists; Asthma; Bronchodilator Agents; Child; Child, Preschool; Humans; Infant; | 1988 |
New concepts in bronchodilator therapy.
Topics: Adrenal Cortex Hormones; Asthma; Atropine; Bronchodilator Agents; Calcium Channel Blockers; Fenotero | 1986 |
Chronobiology and asthma. II. Body-time-dependent differences in the kinetics and effects of bronchodilator medications.
Topics: Adult; Airway Resistance; Asthma; Bronchodilator Agents; Chronobiology Phenomena; Delayed-Action Pre | 1987 |
The management of status asthmaticus in infants and children.
Topics: Adrenal Cortex Hormones; Asthma; Bicarbonates; Child; Humans; Infant; Infusions, Parenteral; Isoprot | 1985 |
Effects of enprofylline and theophylline may show the role of adenosine.
Topics: Adenosine; Animals; Asthma; Brain; Bronchodilator Agents; Caffeine; Diuresis; Fatty Acids, Nonesteri | 1986 |
Cyclic AMP-dependent regulation of lipid mediators in white cells. A unifying concept for explaining the efficacy of theophylline in asthma.
Topics: Animals; Asthma; Cyclic AMP; Dinoprostone; Humans; Leukocytes; Lipids; Lung; Prostaglandins E; Theop | 1987 |
[Peculiarities of theophylline therapy in childhood].
Topics: Adolescent; Asthma; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Respiratory Distress S | 1988 |
Biologic rhythms and medicine.
Topics: Adrenal Cortex Hormones; Asthma; Chronobiology Phenomena; Circadian Rhythm; Humans; Theophylline | 1988 |
Sustained release theophylline preparations. Practical recommendations for prescribing and therapeutic drug monitoring.
Topics: Asthma; Delayed-Action Preparations; Humans; Theophylline | 1988 |
Asthma: current therapeutic approach.
Topics: Acute Disease; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Child; Child, Preschool; Huma | 1988 |
Biochemical and cellular basis for circadian rhythms in obstructive lung disease and implications for theophylline therapy.
Topics: Asthma; Circadian Rhythm; Humans; Lung Diseases, Obstructive; Theophylline | 1988 |
[Pharmacokinetics of theophylline in children with acute asthmatic crisis].
Topics: Asthma; Child; Child, Preschool; Female; Humans; Male; Theophylline; Time Factors | 1988 |
Theophylline: primary or tertiary drug? A brief review.
Topics: Asthma; Child, Preschool; Cromolyn Sodium; Humans; Seizures; Theophylline | 1987 |
Late asthmatic responses.
Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Cyclooxygenase Inhibitors; | 1987 |
Late asthmatic responses.
Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Cyclooxygenase Inhibitors; | 1987 |
Late asthmatic responses.
Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Cyclooxygenase Inhibitors; | 1987 |
Late asthmatic responses.
Topics: Allergens; Animals; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Cyclooxygenase Inhibitors; | 1987 |
Airway hyperresponsiveness: therapeutic implications.
Topics: Adrenal Cortex Hormones; Allergens; Asthma; Child; Cromolyn Sodium; Environment, Controlled; Humans; | 1987 |
Airway hyperresponsiveness and late asthmatic responses.
Topics: Adrenal Cortex Hormones; Allergens; Anti-Inflammatory Agents; Asthma; Bronchial Spasm; Cromolyn Sodi | 1988 |
Global perspectives in the management of asthma.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Cromolyn Sodium; Humans; Parasympatholytics; | 1988 |
[Therapy of asthma with theophylline preparations].
Topics: Asthma; Humans; Theophylline | 1988 |
The effects of theophylline on airway inflammation.
Topics: Adult; Animals; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Provocation Tests; Bronchitis; | 1987 |
Theophylline and mucociliary clearance.
Topics: Aminophylline; Animals; Asthma; Bronchitis; Cilia; Clinical Trials as Topic; Dogs; Humans; Lung Dise | 1987 |
Compliance and self-help in an office practice.
Topics: Asthma; Child; Child, Preschool; Health Facilities; Humans; Patient Compliance; Physician-Patient Re | 1987 |
Effects of theophylline on learning and behavior: reason for concern or concern without reason?
Topics: Asthma; Child; Child Behavior; Child Behavior Disorders; Depression; Humans; Learning; Learning Disa | 1987 |
Airway smooth muscle and disease workshop: theophylline.
Topics: Animals; Asthma; Bronchi; Bronchodilator Agents; Guinea Pigs; Humans; In Vitro Techniques; Muscle Re | 1987 |
[Methylxanthine preparations in the therapy of bronchial asthma].
Topics: Asthma; Delayed-Action Preparations; Drug Evaluation; Humans; Theophylline; Xanthines | 1987 |
Day-night patterns in bronchial patency and dyspnea: basis for once-daily and unequally divided twice-daily theophylline dosing schedules.
Topics: Asthma; Bronchi; Circadian Rhythm; Drug Administration Schedule; Dyspnea; Humans; Theophylline | 1987 |
Treatment of asthma by a controlled-release theophylline tablet formulation: a review of the North American experience with nocturnal dosing.
Topics: Asthma; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Drug Administration | 1987 |
Sustained-release theophylline and nocturnal asthma, once-daily and unequal dosing schedules.
Topics: Asthma; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedule; Food; Humans; T | 1987 |
Anti asthmatic effects and pharmacokinetics of enprofylline--a new xanthine derivate.
Topics: Administration, Oral; Asthma; Bronchi; Female; Humans; Infusions, Intravenous; Male; Theophylline; X | 1987 |
[Importance of the laboratory in optimizing anti-asthma therapy with theophylline].
Topics: Aged; Aminophylline; Asthma; Female; Humans; Male; Middle Aged; Retrospective Studies; Theophylline | 1987 |
[Significance and evaluation of theophyllinemia in clinical medicine].
Topics: Asthma; Humans; Theophylline | 1986 |
Clinical and pharmacokinetic concerns of 24-hour dosing with theophylline.
Topics: Absorption; Asthma; Delayed-Action Preparations; Dose-Response Relationship, Drug; Epinephrine; Huma | 1986 |
Respiratory pharmacology. Methylxanthines.
Topics: Administration, Oral; Aminophylline; Asthma; Drug Interactions; Humans; Injections, Intravenous; Kin | 1986 |
Therapeutic effect and dosing strategies for theophylline in the treatment of chronic asthma.
Topics: Asthma; Chronic Disease; Humans; Theophylline | 1986 |
Asthma in children: emergency management.
Topics: Asthma; Bronchodilator Agents; Child; Child, Preschool; Emergency Medical Services; Humans; Oxygen; | 1987 |
Status asthmaticus.
Topics: Adolescent; Adult; Aged; Asthma; Atropine; Bronchi; Bronchoscopy; Child; Child, Preschool; Fluid The | 1985 |
A pharmacokinetic approach to the use of theophylline in status asthmaticus.
Topics: Adolescent; Adult; Age Factors; Asthma; Child; Dose-Response Relationship, Drug; Drug Administration | 1985 |
Current concepts. Management of asthma during pregnancy.
Topics: Adrenal Cortex Hormones; Asthma; Birth Weight; Epinephrine; Female; Fetal Death; Fetus; Hormones; Hu | 1985 |
Update on the pharmacodynamics and pharmacokinetics of theophylline.
Topics: Asthma; Biotransformation; Delayed-Action Preparations; Drug Interactions; Food; Humans; Intestinal | 1985 |
Slow-release theophylline for the management of chronic asthma.
Topics: Asthma; Biological Availability; Child; Chronic Disease; Delayed-Action Preparations; Half-Life; Hum | 1985 |
Asthma: recent developments in treatment.
Topics: Acute Disease; Aminophylline; Aspirin; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Bude | 1985 |
Autonomic imbalance in asthma with special reference to beta adrenergic blockade.
Topics: Acetylcholine; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Asthma; Blood Glucose; Brad | 1972 |
Oral theophylline preparations--a review of their clinical efficacy in the treatment of bronchial asthma.
Topics: Acute Disease; Administration, Oral; Adrenal Cortex Hormones; Antacids; Antitussive Agents; Asthma; | 1974 |
[Treatment of bronchial asthma].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Anti-Bacterial Agents; Asthma; Autonomic | 1974 |
Current concepts of the pathogenesis and management of asthma.
Topics: Adrenergic beta-Antagonists; Aerosols; Allergens; Antibodies; Asthma; Bronchodilator Agents; Catecho | 1970 |
"Combination" anti-asthmatic therapy: recent developments.
Topics: Aminophylline; Asthma; Barbiturates; Ephedrine; Expectorants; Guaifenesin; Humans; Hydroxyzine; Hypn | 1974 |
The treatment of bronchial asthma.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Aerosols; Allergens; Amino Alcohols; Aminophyllin | 1971 |
[Antiasthmatics. 12].
Topics: Adrenal Cortex Hormones; Aminophylline; Anti-Bacterial Agents; Asthma; Atropine; Barbiturates; Bronc | 1967 |
[Beta-adrenergic blockade theory--impaired function of the autonomic nerve in asthma].
Topics: Adenylyl Cyclases; Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Antibody Formation; Asthma; | 1971 |
[The acute respiratory insufficiency].
Topics: Acute Disease; Asthma; Blood Gas Analysis; Bronchitis; Butyrates; Chronic Disease; Cortisone; Electr | 1972 |
Drug treatment in bronchial asthma.
Topics: Acetylcysteine; Anti-Bacterial Agents; Asthma; Bronchodilator Agents; Caffeine; Drug Combinations; E | 1973 |
Differential diagnosis of childhood asthma.
Topics: Age Factors; Asthma; Child; Child Health Services; Child, Institutionalized; Cystic Fibrosis; Defici | 1974 |
555 trials available for theophylline and Asthma, Bronchial
| Article | Year |
|---|---|
Tiotropium for refractory cough in asthma via cough reflex sensitivity: A randomized, parallel, open-label trial.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Asthma; Ca | 2023 |
A long-term clinical trial on the efficacy and safety profile of doxofylline in Asthma: The LESDA study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Albuterol; Asthma; Bronchodilator Agents; Fema | 2020 |
Theophylline Acetaldehyde as the Initial Product in Doxophylline Metabolism in Human Liver.
Topics: Acetaldehyde; Adult; Animals; Asthma; Bronchodilator Agents; Cytochrome P-450 Enzyme System; Female; | 2020 |
[Clinical efficacies of inhaled corticosteroids plus theophylline in the treatment of bronchial asthma].
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Aminophylline; Asthma; Budesonide; Drug | 2013 |
Pulmonary function assessment in mild to moderate persistent asthma patients receiving montelukast, doxofylline, and tiotropium with budesonide: a randomized controlled study.
Topics: Acetates; Adult; Asthma; Bronchodilator Agents; Budesonide; Cyclopropanes; Drug Therapy, Combination | 2014 |
Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: which is the best among the second-line treatment? A randomized trial.
Topics: Acetates; Adolescent; Adult; Asthma; Bronchodilator Agents; Budesonide; Cyclopropanes; Drug Therapy, | 2015 |
Intervention Studies of Inhaled Corticosteroids Combined with Long-acting Theophylline or Long-acting β
Topics: Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Aerosols; Aged; Albuterol; Anti | 2016 |
Improvement in symptoms and pulmonary function of asthmatic patients due to their treatment according to the Global Strategy for Asthma Management (GINA).
Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; | 2008 |
Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Analysis of Variance; Anti-Asth | 2009 |
Effects of the addition of Beta2-agonist tulobuterol patches to inhaled corticosteroid in patients with asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Aged; Asthma; | 2009 |
The effect of active and passive household cigarette smoke exposure on pregnant women with asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Beclomethasone; Disease Progression | 2010 |
Shared treatment decision making improves adherence and outcomes in poorly controlled asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Beclomethasone; Br | 2010 |
Shared treatment decision making improves adherence and outcomes in poorly controlled asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Beclomethasone; Br | 2010 |
Shared treatment decision making improves adherence and outcomes in poorly controlled asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Beclomethasone; Br | 2010 |
Shared treatment decision making improves adherence and outcomes in poorly controlled asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Beclomethasone; Br | 2010 |
Comparison of oral theophylline and salbutamol by inhalation in asthmatic patients.
Topics: Administration, Inhalation; Administration, Oral; Adult; Aged; Albuterol; Asthma; Bronchodilator Age | 1976 |
Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma.
Topics: Adolescent; Adult; Aged; Albuterol; Androstadienes; Asthma; Bronchodilator Agents; Circadian Rhythm; | 2013 |
Comparison of second controller medications in addition to inhaled corticosteroid in patients with moderate asthma.
Topics: Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Budesonide; D | 2002 |
Effects of adding either a leukotriene receptor antagonist or low-dose theophylline to a low or medium dose of inhaled corticosteroid in patients with persistent asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Anti-Asthmatic Agents; Asthma; Beclomethaso | 2002 |
Effect of long-term treatment with inhaled budesonide or theophylline on lung function, airway reactivity and asthma symptoms.
Topics: Administration, Inhalation; Administration, Oral; Asthma; Bronchodilator Agents; Budesonide; Double- | 2002 |
Reassessment of theophylline use for severe asthma exacerbation: is it justified in critically ill hospitalized patients?
Topics: Asthma; Bronchodilator Agents; Critical Illness; Double-Blind Method; Hospitalization; Humans; Sever | 2002 |
Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma.
Topics: 5' Flanking Region; Adolescent; Adult; Aged; Alleles; Asthma; Bayes Theorem; Cytochrome P-450 CYP1A2 | 2003 |
Low-dose theophylline in childhood asthma: a placebo-controlled, double-blind study.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Airway Resistance; Androstadienes; | 2003 |
Comparative efficacy of once-daily therapy with inhaled corticosteroid, leukotriene antagonist or sustained-release theophylline in patients with mild persistent asthma.
Topics: Acetates; Administration, Inhalation; Adrenergic beta-2 Receptor Antagonists; Adult; Anti-Asthmatic | 2003 |
Randomized trial of inhaled beclomethasone dipropionate versus theophylline for moderate asthma during pregnancy.
Topics: Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchodilator Age | 2004 |
[Clinical study on doxofylline injection in treatment of children with acute asthma attacks].
Topics: Acute Disease; Asthma; Bronchodilator Agents; Child; Child, Preschool; Female; Humans; Infant; Infus | 2004 |
Effects of high-dose inhaled fluticasone propionate on the hypothalamic-pituitary-adrenal axis in asthmatic patients with severely impaired lung function.
Topics: Adult; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Beclomethasone; Blood Proteins; Bre | 2004 |
Effects of different anti-asthmatic agents on induced sputum and eosinophil cationic protein in mild asthmatics.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Anti-Asthmatic Agents; Asthma; Blood Cel | 2004 |
Bronchodilating effects of salmeterol, theophylline and their combination in patients with moderate to severe asthma.
Topics: Administration, Oral; Adult; Albuterol; Asthma; Bronchodilator Agents; Cross-Over Studies; Delayed-A | 2005 |
Comparison of inhaled corticosteroid combined with theophylline and double-dose inhaled corticosteroid in moderate to severe asthma.
Topics: Administration, Inhalation; Adult; Asthma; Beclomethasone; Bronchodilator Agents; Dose-Response Rela | 2005 |
Efficacy and safety of intravenous theophylline administration for treatment of mild acute exacerbation of bronchial asthma.
Topics: Acute Disease; Aged; Asthma; Bronchodilator Agents; Female; Humans; Injections, Intravenous; Male; M | 2005 |
Pharmacokinetics of theophylline after administration of suppositories formulation.
Topics: Administration, Rectal; Adult; Asthma; Biological Availability; Child; Cross-Over Studies; Enzyme-Li | 2005 |
Plant-based formulation for bronchial asthma: a controlled clinical trial to compare its efficacy with oral salbutamol and theophylline.
Topics: Administration, Oral; Adult; Albendazole; Albuterol; Asthma; Double-Blind Method; Drug Therapy, Comb | 2006 |
Double-blind, randomised, controlled trial assessing controller medications in asthma.
Topics: Acetates; Adolescent; Adult; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Budesonide; Cyclo | 2006 |
[Clinical efficacy of low-dose oral theophylline for treating mild asthma].
Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Female; Humans; Male; Middle Aged; Respi | 2006 |
Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios.
Topics: Alleles; Asthma; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Genotype; Humans; Pharmacogenetic | 2006 |
Allergic rhinitis and sinusitis in asthma: differential effects on symptoms and pulmonary function.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchodilator Agents; Child; Child, Preschool; | 2006 |
Effect of obesity on clinical presentation and response to treatment in asthma.
Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Cyclopropanes; Cytokines; Dis | 2006 |
Effects of salmeterol in patients with persistent asthma receiving inhaled corticosteroid plus theophylline.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Aged; Albuterol; Asthma; Bronchodilator | 2007 |
Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma.
Topics: Acetates; Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Cyclopropanes; Double-Bl | 2007 |
A randomized open-label comparative study of montelukast versus theophylline added to inhaled corticosteroid in asthmatic children.
Topics: Acetates; Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Anti-Asthmatic Agents; As | 2006 |
The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics.
Topics: Acetates; Adult; Anti-Asthmatic Agents; Asthma; Biomarkers; C-Reactive Protein; Cardiovascular Disea | 2007 |
Prevalence of alpha-1 antitrypsin deficiency in poorly controlled asthma--results from the ALA-ACRC low-dose theophylline trial.
Topics: Acetates; Adolescent; Adult; Aged; alpha 1-Antitrypsin Deficiency; Asthma; Bronchodilator Agents; Co | 2007 |
[Comparative study on the clinical efficacy and safety of inhaled corticosteroid combined with slow-release theophylline compared to seretide in the control of asthma in children].
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Child; Child, Preschool; Drug Interacti | 2007 |
Comparison of salmeterol/fluticasone propionate (FP) combination with FP+sustained release theophylline in moderate asthma patients.
Topics: Administration, Inhalation; Adult; Aged; Albuterol; Androstadienes; Asthma; Bronchodilator Agents; D | 2008 |
Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma.
Topics: Albuterol; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Child; Child, Preschool; Double-Bli | 2008 |
Sleep quality in asthma: results of a large prospective clinical trial.
Topics: Acetates; Adult; Asthma; Bronchodilator Agents; Cyclopropanes; Double-Blind Method; Female; Humans; | 2008 |
The effect on the pulmonary ventilation of different theophylline derivatives compared to adrenaline and isoprenaline.
Topics: Asthma; Epinephrine; Female; Humans; Isoproterenol; Male; Middle Aged; Respiration; Theophylline | 1966 |
[Treatment of seasonal asthmatic symptoms. A multicentre trial to compare the effects of ketotifen and disodium cromoglycate (author's transl)].
Topics: Adrenergic beta-Agonists; Asthma; Beclomethasone; Bronchitis; Clinical Trials as Topic; Cromolyn Sod | 1980 |
Single-dose slow-release aminophylline at night prevents nocturnal asthma.
Topics: Adrenergic beta-Agonists; Adult; Aged; Aminophylline; Asthma; Circadian Rhythm; Clinical Trials as T | 1982 |
Double-blind comparative trial of Nuelin Depot and TheoDur with adjusted dosage in asthmatic adults.
Topics: Adrenergic beta-Agonists; Adult; Aerosols; Aged; Asthma; Bronchodilator Agents; Clinical Trials as T | 1981 |
Does theophylline potentiate inhaled beta 2-agonists?
Topics: Administration, Intranasal; Administration, Oral; Adrenergic beta-Agonists; Asthma; Blood Pressure; | 1982 |
Effects of oral theophylline combined with oral and inhaled beta-2-adrenostimulants in asthmatics.
Topics: Administration, Intranasal; Administration, Oral; Adrenergic beta-Agonists; Adult; Aged; Asthma; Blo | 1982 |
[Ketotifen in the prevention of bronchial asthma. International therapeutic evaluation].
Topics: Adrenal Cortex Hormones; Adult; Anaphylaxis; Asthma; Bronchial Provocation Tests; Bronchodilator Age | 1981 |
Combined theophylline/beta-agonists maintenance therapy in chronic asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Asthma; Clinical Trials as Topic; Double-Blind Me | 1983 |
Pretreatment of exercise-induced asthma with beta-2 agonists inhaled from RV to TLC or at TLC. A preliminary report.
Topics: Administration, Intranasal; Adult; Asthma; Asthma, Exercise-Induced; Clinical Trials as Topic; Gluco | 1983 |
Poor bronchodilator effect of oral etamiphylline in asthmatic children.
Topics: Administration, Oral; Asthma; Bronchodilator Agents; Child; Clinical Trials as Topic; Double-Blind M | 1984 |
Postgraduate course presentation. Cromolyn sodium in the treatment of asthma: changing concepts.
Topics: Administration, Intranasal; Airway Obstruction; Animals; Asthma; Bronchial Spasm; Chemotactic Factor | 1981 |
Cromolyn.
Topics: Administration, Intranasal; Adult; Asthma; Asthma, Exercise-Induced; Child; Clinical Trials as Topic | 1983 |
The addition of an aerosol anticholinergic to an oral beta agonist plus theophylline in asthma and bronchitis. A double-blind single dose study.
Topics: Administration, Oral; Adolescent; Adult; Aerosols; Aged; Asthma; Atropine Derivatives; Bronchitis; C | 1982 |
Anticholinergic and sympathomimetic combination therapy of asthma.
Topics: Adolescent; Adult; Aged; Asthma; Blood Pressure; Choline; Clinical Trials as Topic; Double-Blind Met | 1983 |
Combined therapy with ipratropium and theophylline in asthma.
Topics: Adolescent; Adult; Aged; Asthma; Atropine Derivatives; Bronchodilator Agents; Drug Therapy, Combinat | 1984 |
[Bronchodilators].
Topics: Animals; Asthma; Atropine Derivatives; Bronchodilator Agents; Clinical Trials as Topic; Drug Interac | 1984 |
Protective effect of oral oxyphenonium bromide, terbutaline and theophylline against the bronchial obstructive effects of inhaled histamine, acetylcholine and propranolol.
Topics: Acetylcholine; Administration, Oral; Adolescent; Adult; Asthma; Bronchi; Bronchial Provocation Tests | 1984 |
Relative bioavailability of two sustained-release theophylline formulations versus an immediate-release preparation.
Topics: Absorption; Asthma; Biological Availability; Clinical Trials as Topic; Delayed-Action Preparations; | 1983 |
Combination low-dose metaproterenol-theophylline therapy in asthma.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Clinical Trials as Topic; Drug Combinations; Drug T | 1983 |
Comparison of bronchodilator effects of oral salbutamol and theophylline and their combination with hydroxyzine.
Topics: Administration, Oral; Adult; Albuterol; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug | 1983 |
A 21-day double-blind study of the effect of adding sustained-release theophylline (Nuelin SA) to inhaled salbutamol in patients with asthma.
Topics: Adult; Aged; Albuterol; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind | 1983 |
Intravenous administration of enprofylline to asthmatic patients.
Topics: Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infusions, Parenteral; | 1983 |
Study of oxtriphylline SA in 50 asthmatics.
Topics: Adult; Aged; Aminophylline; Asthma; Choline; Clinical Trials as Topic; Drug Administration Schedule; | 1983 |
Clinical efficiency of neobiphyllineR-studies on lung function and serum levels after rectal application of a combination of methyl-xanthines.
Topics: Adult; Aged; Airway Resistance; Aminophylline; Asthma; Clinical Trials as Topic; Drug Combinations; | 1983 |
A controlled comparison of slow-release theophylline, ketotifen and placebo in the prophylaxis of asthma in young children.
Topics: Administration, Oral; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Delayed-Action Prep | 1983 |
The duration of protection from exercise-induced asthma by inhaled salbutamol, and a comparison with inhaled reproterol.
Topics: Adolescent; Adult; Albuterol; Asthma; Asthma, Exercise-Induced; Clinical Trials as Topic; Drug Combi | 1983 |
Terbutaline sulfate and isoproterenol sulfate (metered dose aerosols) in the treatment of asthma.
Topics: Adolescent; Adult; Aerosols; Asthma; Clinical Trials as Topic; Double-Blind Method; Humans; Isoprote | 1983 |
[1-second value and oscillatory airway resistance in the evaluation of the effectiveness of beta-adrenergic agents under general practice conditions].
Topics: Airway Resistance; Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Clinical Trials as To | 1983 |
[Asthma therapy. Clinical trial of 2 proxyphylline/ephedrine combinations with immediate and long-term effect].
Topics: Adult; Aminophylline; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Drug Combinatio | 1983 |
[Multicenter study of a slow-release theophylline: armophylline].
Topics: Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Male; Respiratory Fun | 1983 |
[Therapeutic effect of bronchospasmin in bronchial asthma patients].
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Chronic Disease; Clinical Trials as Topic; Drug Co | 1983 |
Double-blind comparisons of slow-release theophylline, ketotifen and placebo for prophylaxis of asthma in young children.
Topics: Asthma; Child; Child, Preschool; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind | 1984 |
Controlled-release theophylline and proxyphylline in asthmatics: a comparative study.
Topics: Adult; Aged; Aminophylline; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Bl | 1984 |
[Clinical trial of a pediatric oral sustained-release theophylline preparation].
Topics: Administration, Oral; Adolescent; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Delayed | 1984 |
Effects of theophylline on inhaled methacholine and histamine in asthmatic children.
Topics: Adolescent; Asthma; Bronchi; Bronchial Provocation Tests; Child; Female; Histamine; Humans; Male; Me | 1984 |
A comparative trial of two slow-release theophylline tablets in the treatment of asthma; Nuelin S.A. and Theocontin Continus tablets.
Topics: Adult; Aged; Airway Resistance; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Dose- | 1984 |
Continuous treatment of asthmatic patients with enprofylline and theophylline.
Topics: Adult; Aged; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Double-Blind Method; Female; H | 1984 |
Verofylline, a methylxanthine bronchodilator, in asthma.
Topics: Administration, Oral; Adult; Asthma; Bronchi; Bronchodilator Agents; Clinical Trials as Topic; Doubl | 1984 |
Aerosol formulations of terbutaline and isoproterenol in theophylline-stabilized asthmatic patients.
Topics: Adolescent; Adult; Aerosols; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Humans; | 1984 |
Serum profile and bioavailability of a controlled-release theophylline formulation for once-daily use: comparison with a 12-hr preparation.
Topics: Adult; Aged; Asthma; Biological Availability; Bronchitis; Clinical Trials as Topic; Delayed-Action P | 1984 |
Relationship between theophylline pharmacokinetics and clinical relevance.
Topics: Adolescent; Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparations; Female; Forced Exp | 1984 |
Sustained release theophylline in nocturnal asthma.
Topics: Adolescent; Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Metho | 1984 |
A comparison of cromolyn and bronchodilators in patients with mild to moderately severe asthma in an office practice.
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Cromolyn Sodium; Femal | 1983 |
Cromolyn therapy in children.
Topics: Aerosols; Age Factors; Asthma; Asthma, Exercise-Induced; Child; Child, Preschool; Clinical Trials as | 1983 |
A double-blind study comparing the effectiveness of cromolyn sodium and sustained-release theophylline in childhood asthma.
Topics: Adolescent; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Cromolyn Sodium; Delayed-Acti | 1984 |
Combination drug therapy in children with exercise-induced bronchospasm.
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Child; Cromolyn Sodium; Drug Therapy, Combination; Exe | 1984 |
Pretreatment of exercise-induced asthma in adults with aerosols and pulverized tablets.
Topics: Administration, Oral; Adolescent; Adult; Aerosols; Albuterol; Asthma; Asthma, Exercise-Induced; Clin | 1980 |
Synergism between ipratropium and theophylline in asthma.
Topics: Adult; Asthma; Atropine Derivatives; Clinical Trials as Topic; Double-Blind Method; Drug Synergism; | 1981 |
Erratic absorption of a slow-release theophylline sprinkle product.
Topics: Absorption; Asthma; Biological Availability; Capsules; Child; Delayed-Action Preparations; Female; F | 1984 |
Comparison of oral enprofylline and theophylline in asthmatic patients.
Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Female; Humans; Male; Middle Aged; Spiro | 1984 |
[Peculiarities of the pharmacokinetics and pharmacodynamics of theophylline in children].
Topics: Adolescent; Asthma; Bronchitis; Caffeine; Child; Child, Preschool; Chromatography, High Pressure Liq | 1984 |
[Comparison of 2 theophylline delayed-action preparations of different galenic forms].
Topics: Adolescent; Adult; Aged; Aminophylline; Asthma; Bronchitis; Delayed-Action Preparations; Drug Admini | 1983 |
Dyphylline versus theophylline: a double-blind comparative evaluation.
Topics: Adolescent; Asthma; Bronchial Spasm; Child; Double-Blind Method; Dyphylline; Female; Forced Expirato | 1983 |
Long-term treatment of children with sustained-release theophylline.
Topics: Asthma; Child; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Placebos; Ran | 1983 |
Comparison of a sustained-release preparation (Theo-Dur) with a conventional preparation (Nuelin) in the treatment of chronic asthma.
Topics: Adult; Aged; Asthma; Chronic Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; | 1983 |
A comparative trial of choline theophyllinate and controlled release aminophylline in chronic childhood asthma.
Topics: Adolescent; Aminophylline; Asthma; Child; Choline; Chronic Disease; Double-Blind Method; Female; Hum | 1983 |
The influence of ketotifen and aminophylline on the central and peripheral airways.
Topics: Adult; Aged; Aminophylline; Asthma; Double-Blind Method; Female; Humans; Ketotifen; Lung Diseases, O | 1983 |
Concomitant bitolterol mesylate aerosol and theophylline for asthma therapy, with 24 hr electrocardiographic monitoring.
Topics: Adolescent; Adult; Aerosols; Aged; Asthma; Child; Drug Therapy, Combination; Electrocardiography; Et | 1984 |
Quantitative gastroesophageal reflux and pulmonary function in asthmatic children and normal adults receiving placebo, theophylline, and metaproterenol sulfate therapy.
Topics: Adolescent; Adult; Asthma; Child; Female; Gastroesophageal Reflux; Humans; Male; Metaproterenol; Pla | 1984 |
Effects of oral theophylline and oral salbutamol in the treatment of asthma.
Topics: Adolescent; Albuterol; Asthma; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Drug | 1982 |
[Therapy of obstructive respiratory tract diseases with pure theophylline retard].
Topics: Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Lung Diseases, Obstru | 1982 |
A double-blind comparative trial between two sustained-release theophylline preparations with individual doses in asthmatic in-patients.
Topics: Adolescent; Adult; Aged; Airway Obstruction; Asthma; Clinical Trials as Topic; Delayed-Action Prepar | 1982 |
[Clinical experience with theophylline in slow-release form (Theo-dur)].
Topics: Adolescent; Adult; Aged; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Female; Huma | 1982 |
Combined treatment with sustained-release theophylline and beta2-adrenoceptor-stimulating agents in chronic childhood asthma.
Topics: Adolescent; Albuterol; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Delayed-Action Prep | 1981 |
Nebulised cromoglycate, theophylline, and placebo in preschool asthmatic children.
Topics: Activities of Daily Living; Aerosols; Asthma; Child, Preschool; Clinical Trials as Topic; Cromolyn S | 1981 |
Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid?
Topics: Adolescent; Aminophylline; Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparations; Dou | 1982 |
Comparison of nebulised sodium cromoglycate and oral theophylline in controlling symptoms of chronic asthma in pre-school children: a double blind study.
Topics: Administration, Oral; Aerosols; Albuterol; Asthma; Child; Child, Preschool; Clinical Trials as Topic | 1982 |
Long-term treatment with oral sustained-release theophylline.
Topics: Administration, Oral; Adolescent; Adult; Aerosols; Asthma; Bronchodilator Agents; Chronic Disease; D | 1982 |
Sustained-release theophylline. Pharmacokinetic and therapeutic comparison of two preparations.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Hu | 1983 |
Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma.
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Ambulatory Care; Asthma; Bronchodilator A | 1983 |
Adverse effects of brompheniramine on pulmonary function in a subset of asthmatic children.
Topics: Asthma; Brompheniramine; Child; Female; Forced Expiratory Volume; Humans; Male; Maximal Midexpirator | 1983 |
[Comparative subacute study of the effects and side effects of a non-depot theophylline preparation (Euspirax) and a depot preparation (Euphyllin retard)--a contribution to long-term therapy of asthma].
Topics: Adolescent; Adult; Aminophylline; Asthma; Bronchodilator Agents; Choline; Delayed-Action Preparation | 1983 |
Management of acute asthma in childhood. A randomized evaluation of beta-adrenergic agents.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Adult; Amino Alcohols; Aminophylline; Asthma; | 1980 |
Efficacy of orally administered salbutamol and theophylline in pre-schoolchildren with asthma.
Topics: Administration, Oral; Airway Resistance; Albuterol; Asthma; Child, Preschool; Clinical Trials as Top | 1980 |
Slow-release oral salbutamol and aminophylline in nocturnal asthma: relation of overnight changes in lung function and plasma drug levels.
Topics: Adolescent; Adult; Aged; Albuterol; Aminophylline; Asthma; Chronic Disease; Circadian Rhythm; Clinic | 1980 |
The value of maintenance theophylline in steroid-dependent asthma.
Topics: Adolescent; Adult; Asthma; Beclomethasone; Child; Clinical Trials as Topic; Double-Blind Method; For | 1981 |
Theophylline and aerosolized terbutaline in the treatment of bronchial asthma. Double-blind comparison of optimal doses.
Topics: Adult; Aerosols; Aged; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combinat | 1980 |
Inhibition of methacholine-induced bronchoconstriction with reproterol, a new beta agonist-xanthine derivative.
Topics: Adult; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Double-Blind Method; Drug Combinatio | 1981 |
Inhibition of antigen-induced bronchoconstriction with reproterol, a new beta agonist-xanthine derivative.
Topics: Adult; Aged; Antigens; Asthma; Bronchial Provocation Tests; Clinical Trials as Topic; Double-Blind M | 1981 |
Clinical efficacy trial: theophylline vs (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Clinical Trials as Topic | 1980 |
Value of combining B2 sympathomimetic metered aerosol and oral theophylline in children with asthma.
Topics: Administration, Oral; Adolescent; Aerosols; Asthma; Child; Child, Preschool; Clinical Trials as Topi | 1981 |
Effectiveness of terbutaline and theophylline alone and in combination in exercise-induced bronchospasm.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Child; Clinical Trials as Topic; Double-Blind M | 1981 |
[Postoperative respiratory therapy: bronchospasmolytic activity and side-effects of some recently introduced beta-sympatheticomimetic agents (author's transl)].
Topics: Adult; Aged; Asthma; Bronchial Spasm; Bronchitis; Clinical Trials as Topic; Drug Combinations; Ethan | 1981 |
Comparison of serum theophylline levels with plain and slow-release aminophylline in patient with airway obstruction.
Topics: Adult; Aged; Aminophylline; Asthma; Bronchitis; Clinical Trials as Topic; Delayed-Action Preparation | 1981 |
A double-blind, placebo-controlled evaluation of (dl)-3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione in exercise-induced bronchospasm.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Clinical Trials as Topic; Double-Bli | 1981 |
Interaction between proxyphylline and salbutamol.
Topics: Adolescent; Adult; Albuterol; Aminophylline; Animals; Asthma; Bronchodilator Agents; Clinical Trials | 1981 |
[Obstructive airway diseases. Basic therapy with pure theophylline in retard form].
Topics: Adult; Aged; Airway Resistance; Asthma; Bronchitis; Clinical Trials as Topic; Delayed-Action Prepara | 1982 |
Comparison of orally administered metaproterenol and theophylline in the control of chronic asthma.
Topics: Administration, Oral; Adolescent; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Double-B | 1982 |
[Theophylline in allergic bronchial asthma (author's transl)].
Topics: Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; The | 1982 |
Comparison of the long-term effect of fenoterol hydrobromide and theophylline syrups in pre-school asthmatic children.
Topics: Asthma; Child; Child, Preschool; Clinical Trials as Topic; Dosage Forms; Ethanolamines; Female; Feno | 1982 |
A comparison of metaproterenol and theophylline for control of childhood asthma.
Topics: Adolescent; Asthma; Child; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Metaprotereno | 1982 |
Emergency room of treatment of asthma. Relationships among therapeutic combinations, severity of obstruction and time course of response.
Topics: Adolescent; Adult; Aerosols; Aminophylline; Asthma; Emergencies; Female; Forced Expiratory Volume; H | 1982 |
Sustained-release theophylline: a significant advance in the treatment of childhood asthma.
Topics: Asthma; Child; Consumer Behavior; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Male | 1982 |
Sustained protection with oxtriphylline-SA against allergenic bronchial challenges.
Topics: Adult; Airway Resistance; Aminophylline; Asthma; Bronchial Provocation Tests; Bronchodilator Agents; | 1982 |
Albuterol by aerosol and orally administered theophylline in asthmatic children.
Topics: Administration, Oral; Adolescent; Aerosols; Albuterol; Asthma; Child; Humans; Pulmonary Ventilation; | 1982 |
Stimulation of endogenous catecholamine release by theophylline: a proposed additional mechanism of action for theophylline effects.
Topics: Adrenal Medulla; Adult; Asthma; Blood Pressure; Catecholamines; Dopamine; Epinephrine; Female; Heart | 1982 |
Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation.
Topics: Administration, Intranasal; Administration, Oral; Asthma; Biological Availability; Bronchodilator Ag | 1982 |
The effects of oral doses of theophylline and fenoterol on exercise-induced asthma.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Drug Therapy, Combination; Ethanolamines; Fenoterol; Forced | 1981 |
Theophylline concentrations in serum and saliva after oral microcrystalline and sustained-release preparations in asthmatics.
Topics: Administration, Oral; Adult; Asthma; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; | 1981 |
Bioavailability, efficacy, and tolerance of two sustained-release theophylline dosage forms in adult patients with bronchial asthma.
Topics: Adolescent; Adult; Asthma; Biological Availability; Capsules; Delayed-Action Preparations; Drug Tole | 1981 |
Compliance differences following administration of theophylline at six- and twelve-hour intervals.
Topics: Administration, Oral; Adolescent; Asthma; Child; Delayed-Action Preparations; Female; Humans; Male; | 1980 |
Combined vs. single-entity pharmacologic inhibition of induced asthma.
Topics: Adult; Airway Resistance; Antigens; Asthma; Double-Blind Method; Drug Therapy, Combination; Ephedrin | 1980 |
Bronchodilator effects of low doses of oral theophylline and terbutaline in asthmatic subjects.
Topics: Adult; Aged; Asthma; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Hemodynamics; | 1980 |
Emergency therapy of asthma: comparison of the acute effects of parenteral and inhaled sympathomimetics and infused aminophylline.
Topics: Administration, Intranasal; Adolescent; Adult; Aminophylline; Asthma; Emergencies; Epinephrine; Fema | 1980 |
[Euphyllin retard and "exercise-induced" asthma].
Topics: Asthma; Delayed-Action Preparations; Humans; Physical Exertion; Spirometry; Theophylline | 1980 |
Metaproterenol and theophylline in asthmatic children.
Topics: Adolescent; Asthma; Blood Pressure; Child; Double-Blind Method; Female; Forced Expiratory Volume; Hu | 1980 |
Comparative pharmacodynamics of oxtriphylline PEC tablets vs. elixir in the treatment of asthma.
Topics: Adult; Asthma; Biological Availability; Forced Expiratory Volume; Humans; Kinetics; Middle Aged; Tab | 1980 |
Dose-response study of oral fenoterol in asthmatic children.
Topics: Administration, Oral; Adolescent; Asthma; Child; Dose-Response Relationship, Drug; Ethanolamines; Fe | 1980 |
Efficacy of once daily extended-release theophylline in decreasing the use of inhaled beta 2-agonists in stable, mild-to-moderate asthma patients.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists | 1995 |
Conversion from twice- to once-daily extended-release theophylline treatment in patients with reversible airway obstruction.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchitis; Bronchodilator Agents; Delayed-Action Prepar | 1995 |
The effects of theophylline on mucosal inflammation in asthmatic airways: biopsy results.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Biopsy; Bronchi; CD8-Positive T-Lymphocytes; Double | 1995 |
Measurements of morning and evening airflow grossly underestimate the circadian variability of FEV1 and peak expiratory flow rate in asthma.
Topics: Adult; Asthma; Circadian Rhythm; Cross-Over Studies; Forced Expiratory Volume; Humans; Peak Expirato | 1995 |
A double-blind comparison of inhaled budesonide, long-acting theophylline, and their combination in treatment of nocturnal asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchodilator Agent | 1995 |
Oral slow-release theophylline does not prevent early and late asthmatic response to allergen in sensitized subjects.
Topics: Administration, Oral; Adult; Allergens; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Cr | 1995 |
Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy.
Topics: Adjuvants, Immunologic; Adult; Aged; Asthma; Biopsy; Bronchi; Cross-Over Studies; Female; Humans; Im | 1995 |
Budesonide: treatment of bronchial asthma during childhood.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Function Tests; Asthma; Budesonide; Child; Ch | 1995 |
Effect of three different doses of a slow-release theophylline formulation on bronchial response to inhaled methacholine in asthmatic patients.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Delayed-Action Preparations; | 1995 |
Theophylline vs. budesonide in the treatment of mild-to-moderate bronchial asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Bronchial Provocation Tests; Bronch | 1994 |
Severe bronchial asthma improved on bamifylline. Case report and review.
Topics: Adult; Asthma; Bronchodilator Agents; Humans; Male; Theophylline | 1994 |
[Serum pyridoxal concentration in children during theophylline therapy for bronchial asthma].
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Male; Pyridoxal; Theop | 1994 |
Theophylline effects on cognition, behavior, and learning.
Topics: Adolescent; Asthma; Child; Child Behavior; Cognition; Female; Humans; Learning; Male; Psychological | 1995 |
Efficacy of Uniphyl, salbutamol, and their combination in asthmatic patients on high-dose inhaled steroids.
Topics: Adult; Aged; Aged, 80 and over; Albuterol; Asthma; Beclomethasone; Bronchodilator Agents; Budesonide | 1995 |
Theophylline attenuation of airway responses to allergen: comparison with cromolyn metered-dose inhaler.
Topics: Adolescent; Adult; Allergens; Asthma; Bronchi; Cromolyn Sodium; Cross-Over Studies; Double-Blind Met | 1995 |
The role of methotrexate in the management of steroid-dependent asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Double-Blind Method; For | 1994 |
Anti-inflammatory effects of low-dose oral theophylline in atopic asthma.
Topics: Administration, Oral; Adult; Allergens; Asthma; Bronchi; Bronchoscopy; Dose-Response Relationship, D | 1994 |
Effect of chronic theophylline therapy on brain blood flow and function in adult asthmatics.
Topics: Adult; Aged; Asthma; Brain; Cerebrovascular Circulation; Chronic Disease; Cross-Over Studies; Double | 1994 |
Adequacy of recommended aminophylline loading doses in children.
Topics: Adolescent; Aminophylline; Asthma; Child; Child, Preschool; Drug Administration Schedule; Female; Hu | 1994 |
Long-term xanthine therapy of asthma. Enprofylline and theophylline compared. International Enprofylline Study Group.
Topics: Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Humans; Male; M | 1994 |
[Evaluation of theophylline population pharmacokinetics in adult hospitalized patients using NONMEM analysis].
Topics: Adolescent; Adult; Age Factors; Aged; Asthma; Drug Therapy, Combination; Female; Humans; Lung Diseas | 1994 |
The efficacy and tolerability of inhaled salmeterol and individually dose-titrated, sustained-release theophylline in patients with reversible airways disease.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchodilator Agents; Cros | 1994 |
Bioequivalence of a generic slow-release theophylline tablet in children.
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Child; Cross-Over Studies; Delayed-Action Preparations | 1994 |
Comparison of oral pulse methotrexate with placebo in the treatment of severe glucocorticosteroid-dependent asthma.
Topics: Administration, Oral; Adult; Aged; Asthma; Chronic Disease; Double-Blind Method; Drug Tolerance; Fem | 1994 |
Administration of half-dose theophylline together with ketotifen to asthmatic children--a double-blind, placebo-controlled study.
Topics: Asthma; Child; Child Behavior; Delayed-Action Preparations; Double-Blind Method; Drug Therapy, Combi | 1994 |
[The comparative efficacy of the prolonged-action theophylline preparations Theopek and Euphylong in elderly patients with chronic obstructive lung diseases].
Topics: Aged; Asthma; Bronchitis; Chronic Disease; Delayed-Action Preparations; Female; Humans; Lung Disease | 1993 |
A comparative study of a new once-a-day theophylline preparation with Theo-Dur given twice daily.
Topics: Adolescent; Adult; Asthma; Delayed-Action Preparations; Drug Administration Schedule; Humans; Middle | 1993 |
Multicenter study with ketotifen (Zaditen) oral drop solution in the treatment of wheezy children aged 6 months to 3 years.
Topics: Asthma; Child, Preschool; Double-Blind Method; Female; Follow-Up Studies; Humans; Infant; Ketotifen; | 1993 |
Double-blind randomized cross-over trial of nocturnal elixir theophylline supplementation of a twice-daily sustained-release theophylline tablet formulation in asthmatic patients.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Circadian Rhythm; Delayed-Action Preparations; Doub | 1993 |
Is combined therapy of sympathomimetics and theophylline indicated?
Topics: Adolescent; Adult; Aged; Albuterol; Asthma; Child; Drug Therapy, Combination; Female; Forced Expirat | 1993 |
Effect of inhaled beclomethasone dipropionate on bronchial responsiveness in patients with asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Beclomethasone; Bronchi; Child; Dose-Response | 1993 |
Lack of effect of magnesium-aluminium hydroxide on the absorption of theophylline given as a pH-dependent sustained release preparation.
Topics: Adult; Aged; Aluminum Hydroxide; Asthma; Delayed-Action Preparations; Double-Blind Method; Female; H | 1993 |
Hospital treatment of asthma: lack of benefit from theophylline given in addition to nebulized albuterol and intravenously administered corticosteroid.
Topics: Administration, Inhalation; Adolescent; Albuterol; Asthma; Child; Child, Preschool; Double-Blind Met | 1993 |
Efficacy of intravenously administered theophylline in children hospitalized with severe asthma.
Topics: Administration, Inhalation; Adolescent; Albuterol; Asthma; Child; Double-Blind Method; Drug Administ | 1993 |
Theophylline--an immunomodulatory role in asthma?
Topics: Adjuvants, Immunologic; Administration, Oral; Adolescent; Adult; Allergens; Animals; Asthma; Bronchi | 1993 |
Theophylline increases pyridoxal kinase activity independently from vitamin B6 nutritional status.
Topics: Adult; Aged; Asthma; Dose-Response Relationship, Drug; Double-Blind Method; Erythrocytes; Humans; Mi | 1993 |
[Comparison of two long-acting theophylline preparations in daily evening administration].
Topics: Adult; Aged; Airway Resistance; Asthma; Delayed-Action Preparations; Dose-Response Relationship, Dru | 1993 |
Effect of oral bronchodilators on lung mucociliary clearance during sleep in patients with asthma.
Topics: Aged; Albuterol; Asthma; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Lung; Male; | 1993 |
A randomized controlled trial of computerized pharmacokinetic theophylline dosing versus empiric physician dosing.
Topics: Aged; Asthma; Carbon Dioxide; Decision Making; Drug Therapy, Computer-Assisted; Female; Humans; Hydr | 1993 |
Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children.
Topics: Adolescent; Aerosols; Asthma; Beclomethasone; Child; Chronic Disease; Double-Blind Method; Female; F | 1993 |
Population pharmacokinetics of theophylline. III. Premarketing study for a once-daily administered preparation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Asthma; Bronchodilator Agen | 1995 |
Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking.
Topics: Adult; Aerosols; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Biomarkers; Blood Proteins | 1996 |
Theophylline: potential antiinflammatory effects in nocturnal asthma.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchoalveolar Lavage Fluid; Circadian Rhythm; Cro | 1996 |
Role of theophylline in asthma.
Topics: Asthma; Humans; Theophylline | 1996 |
Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Bro | 1996 |
Significance of the therapeutic range of serum theophylline concentration in the treatment of an attack of bronchial asthma.
Topics: Adrenergic beta-Agonists; Adult; Aminophylline; Asthma; Bronchodilator Agents; Female; Humans; Hydro | 1996 |
Theophylline's effect on neutrophil function and the late asthmatic response.
Topics: Adult; Asthma; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Neutrophi | 1996 |
Controlled-release theophylline inhibits early morning airway obstruction and hyperresponsiveness in asthmatic subjects.
Topics: Administration, Inhalation; Administration, Oral; Adult; Airway Obstruction; Asthma; Circadian Rhyth | 1996 |
Fluticasone propionate compared with theophylline for mild-to-moderate asthma.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Albuterol; Androstadienes | 1996 |
An evaluative study of the short-term effects of once-daily, sustained-release theophylline on sleep in nocturnal asthmatics.
Topics: Adult; Analysis of Variance; Asthma; Bronchodilator Agents; Circadian Rhythm; Cross-Over Studies; De | 1996 |
Influence of treatment with beclomethasone, cromoglycate and theophylline on perception of bronchoconstriction in patients with bronchial asthma.
Topics: Adult; Albuterol; Asthma; Beclomethasone; Bronchoconstriction; Bronchodilator Agents; Cromolyn Sodiu | 1996 |
Clinical application of the Biotrack 516 system for determination of theophylline by a turbidimetric latex agglutination inhibition reaction.
Topics: Anti-Asthmatic Agents; Antibody Specificity; Asthma; Chromatography, High Pressure Liquid; Evaluatio | 1996 |
Effects of theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Biopsy; Bronchodilator Agents; Bronchoscopy; | 1996 |
Comparison of inhaled salmeterol and individually dose-titrated slow-release theophylline in patients with reversible airway obstruction. European Study Group.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Ag | 1996 |
[Sympathomimetics and theophylline: combined use?].
Topics: Adolescent; Adult; Albuterol; Asthma; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug | 1995 |
Efficacy of salmeterol in the treatment of childhood asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Airway Resistance; Albuterol; Asthma; Bronchodilator Agents; C | 1996 |
[Usefulness of "Biotrack Theophylline kit" for measuring serum theophylline concentration in patients with chronic asthma].
Topics: Age Factors; Asthma; Bronchodilator Agents; Child; Child, Preschool; Delayed-Action Preparations; Hu | 1996 |
[Theophyllines of 12- and 24-hour sustained-release. Comparative study].
Topics: Adult; Asthma; Bronchodilator Agents; Cross-Over Studies; Delayed-Action Preparations; Forced Expira | 1996 |
Inhibition of theophylline metabolism by aciclovir.
Topics: Acyclovir; Adult; Animals; Antiviral Agents; Area Under Curve; Asthma; Biotransformation; Bronchodil | 1996 |
Inhaled salmeterol or oral theophylline in nocturnal asthma?
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Adult; Aged; Albuterol; | 1997 |
Intravenous versus oral corticosteroids in the management of acute asthma in children.
Topics: Administration, Oral; Adolescent; Albuterol; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents | 1997 |
Oral fenoterol versus sustained release theophylline in adult asthmatics.
Topics: Administration, Inhalation; Administration, Oral; Adult; Albuterol; Asthma; Bronchodilator Agents; C | 1997 |
Relation between theophylline and circulating vitamin levels in children with asthma.
Topics: Adolescent; Ascorbic Acid; Asthma; Bronchodilator Agents; Child; Female; Humans; Male; Theophylline; | 1996 |
Retention of asthmatic patients in a longitudinal clinical trial.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Behavior; Bias; | 1997 |
Salmeterol versus theophylline in the treatment of asthma.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Al | 1997 |
[Therapy of nocturnal asthma: salmeterol versus nocturnal administration of retard theophylline--comparison of effectiveness and tolerance].
Topics: Adult; Albuterol; Asthma; Bronchodilator Agents; Cross-Over Studies; Delayed-Action Preparations; Do | 1997 |
The effects of the combination of inhaled ipratropium and oral theophylline in asthma.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Analysis of Variance; Asthma; B | 1997 |
[Clinical evaluation of the isotonic solution of theophylline for intravenous injection].
Topics: Adult; Asthma; Bronchodilator Agents; Drug Administration Schedule; Electrocardiography, Ambulatory; | 1996 |
A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Budesonide; Doub | 1997 |
[Inhaled salmeterol or oral theophylline in nocturnal asthma?].
Topics: Administration, Inhalation; Administration, Oral; Albuterol; Asthma; Bronchodilator Agents; Cross-Ov | 1997 |
Effect of a phosphodiesterase 3 inhibitor, cilostazol, on bronchial hyperresponsiveness in elderly patients with asthma.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Aged; Asthma; Bronchial Hyperreactivity; | 1997 |
A randomized controlled trial comparing zileuton with theophylline in moderate asthma. The Zileuton Study Group.
Topics: Adult; Asthma; Bronchodilator Agents; Double-Blind Method; Female; Forced Expiratory Volume; Humans; | 1998 |
Aerosol beclomethasone dipropionate spray compared with theophylline as primary treatment for chronic mild-to-moderate asthma. The American Academy of Allergy, Asthma and Immunology Beclomethasone Dipropionate-Theophylline Study Group.
Topics: Adolescent; Adult; Aerosols; Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchodilator Age | 1998 |
[The effect of an isotonic solution of theophylline 300 on eosinophil cationic protein levels].
Topics: Adult; Asthma; Blood Proteins; Bronchodilator Agents; Eosinophil Granule Proteins; Eosinophils; Huma | 1997 |
Neuropsychological and behavioral changes in asthmatic children treated with beclomethasone dipropionate versus theophylline.
Topics: Administration, Inhalation; Adolescent; Adolescent Behavior; Anti-Asthmatic Agents; Asthma; Beclomet | 1998 |
Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients.
Topics: Adult; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoconstrictor Agents; Br | 1997 |
Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Asthma; Beclomethason | 1997 |
Plasmatic levels of theophylline in asthmatic patients. Comparative evaluations of two different methods.
Topics: Asthma; Child, Preschool; Chromatography, High Pressure Liquid; Drug Monitoring; Enzyme Multiplied I | 1998 |
The airway effects of stopping regular oral theophylline in patients with asthma.
Topics: Administration, Oral; Adult; Asthma; Bronchoconstriction; Bronchodilator Agents; Cyclic AMP; Double- | 1998 |
Comparative study on the clinical efficacy of theophylline variable serum concentrations therapy and round-the-clock therapy.
Topics: Adult; Aged; Asthma; Bayes Theorem; Drug Administration Schedule; Episode of Care; Female; Humans; M | 1998 |
Efficacy of aminophylline in the treatment of acute asthma exacerbation in children.
Topics: Acute Disease; Adolescent; Aminophylline; Asthma; Child; Child, Preschool; Double-Blind Method; Fema | 1998 |
Aerosol beclomethasone dipropionate compared with theophylline as primary treatment of chronic, mild to moderately severe asthma in children, by David G. Tinkelman, MD, et al, Pediatrics, 1993;92:64-77.
Topics: Aerosols; Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchodilator Agents; Child; History, 20th | 1998 |
Long-term treatment of asthmatic patients with salmeterol vs slow-release theophylline.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchodilator Agents; Dela | 1998 |
[Pharmacokinetics of theophylline in sustained-release formulation in young asthmatics].
Topics: Anti-Asthmatic Agents; Area Under Curve; Asthma; Capsules; Child; Delayed-Action Preparations; Doubl | 1998 |
[The anti-inflammatory action of an oral sustained-release theophylline preparation. Results of a clinical pilot study with low dosages].
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Delayed-Action Preparations; Eosi | 1998 |
Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects.
Topics: Adult; Airway Resistance; Asthma; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchodil | 1998 |
One-year follow-up of young children hospitalized for wheezing: the influence of early anti-inflammatory therapy and risk factors for subsequent wheezing and asthma.
Topics: Administration, Inhalation; Administration, Oral; Analysis of Variance; Anti-Asthmatic Agents; Anti- | 1998 |
Effects of theophylline on tolerance to the bronchoprotective actions of salmeterol in asthmatics in vivo.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchi; Bronchial P | 1998 |
[Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma].
Topics: Adolescent; Adult; Aged; Asthma; Beclomethasone; Dose-Response Relationship, Drug; Drug Administrati | 1998 |
Effect of theophylline withdrawal on airway inflammation in asthma.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Asthma; Bronchial Provocation Tests; Do | 1998 |
Theophylline inhibits the late asthmatic response to nighttime antigen challenge in patients with mild atopic asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Circadian Rhythm; Delayed-Action Preparations; Female; F | 1998 |
Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Blood Cell Count; Cells, Cultured; Down-Regulat | 1998 |
[Effect of slow-release theophylline on airway inflammation in bronchial asthma].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchitis; Delayed-Action Preparations; Fem | 1998 |
[Evaluation of theophylline in children hospitalized with asthma attack].
Topics: Aminophylline; Asthma; Bronchodilator Agents; Child, Preschool; Female; Hospitalization; Humans; Inj | 1998 |
Comparative pharmacodynamic-pharmacokinetic correlation of oral sustained-release theophylline formulation in adult asthmatics.
Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cr | 1999 |
Suppression of airway inflammation by theophylline in adult bronchial asthma.
Topics: Administration, Oral; Adult; Asthma; Biomarkers; Blood Proteins; Bronchitis; Bronchodilator Agents; | 1999 |
[The effect of protheo on pulmonary function and the change of its plasma concentration in patients with chronic asthmatic bronchitis].
Topics: Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Delayed-Action Preparations; Female; Hum | 1997 |
Salmeterol vs theophylline: sleep and efficacy outcomes in patients with nocturnal asthma.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchod | 1999 |
[Development and evaluation of parent-related quality of life questionnaires for asthmatic children and their parents or caregivers--evaluation of treatment process with sustained-release theophylline dry syrup].
Topics: Administration, Oral; Asthma; Caregivers; Child, Preschool; Female; Humans; Male; Parents; Quality o | 1999 |
Pharmacokinetic/pharmacodynamic modelling of the eosinopenic and hypokalemic effects of formoterol and theophylline combination in healthy men.
Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug I | 1999 |
[The effect of theophylline on neutrophil and lymphocyte chemotaxis stimulated with fMLP in health subjects and asthma patients].
Topics: Adult; Anti-Inflammatory Agents; Asthma; Chemotaxis, Leukocyte; Female; Humans; Lymphocytes; Male; M | 1999 |
Comparison of the efficacy of inhaled fluticasone propionate, 880 microg/day, with flunisolide, 1500 microg/day, in moderate-to-severe persistent asthma.
Topics: Absenteeism; Administration, Inhalation; Adolescent; Albuterol; Androstadienes; Asthma; Child; Cross | 1999 |
Pharmacokinetic/pharmacodynamic modeling of theophylline in patients with different degrees of airway obstruction.
Topics: Adult; Airway Obstruction; Algorithms; Asthma; Bronchodilator Agents; Female; Forced Expiratory Volu | 1999 |
Comparative study of the pharmacokinetic characteristics of slow release theophylline oral preparations in Thai children with persistent asthma.
Topics: Administration, Oral; Adolescent; Area Under Curve; Asthma; Child; Chronic Disease; Cross-Over Studi | 1999 |
Once-daily theophylline reduces serum eosinophil cationic protein and eosinophil levels in induced sputum of asthmatics.
Topics: Adolescent; Adult; Aged; Asthma; Blood Proteins; Bronchodilator Agents; Eosinophil Granule Proteins; | 2000 |
Higher incidence of elevated body temperature or increased C-reactive protein level in asthmatic children showing transient reduction of theophylline metabolism.
Topics: Adolescent; Asthma; Bronchodilator Agents; C-Reactive Protein; Child; Child, Preschool; Female; Feve | 2000 |
[Control of inhaled triggering factors decreases prolonged drug therapy requirements in patients with asthma].
Topics: Adolescent; Albuterol; Allergens; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Beclometh | 2000 |
Theophylline pharmacokinetics with concomitant steroid and gold therapy.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Auranofin; Bronchodilator Agents; Drug Interactions; Female; H | 2000 |
Effect of a 4-week treatment with theophylline on sputum eosinophilia and sputum eosinophil chemotactic activity in steroid-naive asthmatics.
Topics: Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents; Asthma; Blood Proteins; Cell Coun | 2000 |
Usefulness and safety of theophylline injection form (Theodrip) for the treatment of acute asthma.
Topics: Acute Disease; Adult; Aminophylline; Asthma; Cross-Over Studies; Humans; Middle Aged; Single-Blind M | 2000 |
[Efficacy of sustained-released theophylline on peak expiratory flow rate in asthmatic patients].
Topics: Adult; Aged; Asthma; Delayed-Action Preparations; Humans; Middle Aged; Peak Expiratory Flow Rate; Th | 2000 |
Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice.
Topics: Adolescent; Adult; Aged; Asthma; Beclomethasone; Bronchodilator Agents; Chronic Disease; Double-Blin | 2000 |
Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma.
Topics: Adult; Asthma; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Eosinophilia; Female; | 2001 |
Low-dose theophylline does not exert its anti-inflammatory effects in mild asthma through upregulation of interleukin-10 in alveolar macrophages.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; Cross-Over Studies; Dose-Resp | 2001 |
Effect of theophylline on airway inflammation in asthma.
Topics: Adult; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Blood Proteins; Eosin | 2001 |
Efficacy of inhaled budesonide and oral theophylline in asthmatic subjects.
Topics: Administration, Inhalation; Administration, Oral; Adult; Anti-Inflammatory Agents; Asthma; Bronchodi | 2001 |
Theophylline chronotherapy of nocturnal asthma using bathyphase of circadian rhythm in peak expiratory flow rate.
Topics: Adult; Algorithms; Anti-Asthmatic Agents; Asthma; Chronotherapy; Female; Humans; Male; Peak Expirato | 2001 |
[Effect of low dose of inhaled corticosteroid combined with small dose of oral theophylline on treatment of bronchial asthma].
Topics: Administration, Inhalation; Administration, Oral; Adrenocorticotropic Hormone; Adult; Aged; Asthma; | 2000 |
Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma -- a double-blind randomized placebo-controlled multicentre clinical trial.
Topics: Adrenergic beta-Agonists; Albuterol; Anti-Asthmatic Agents; Asthma; Dose-Response Relationship, Drug | 2002 |
[Effects of once-daily low-dose administration of sustained-release theophylline on airway inflammation and airway hyperresponsiveness in patients with asthma].
Topics: Administration, Oral; Adult; Asthma; Blood Proteins; Bronchial Hyperreactivity; Bronchodilator Agent | 2002 |
A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.
Topics: Adult; Asthma; Base Sequence; Bronchoalveolar Lavage Fluid; Bronchodilator Agents; Case-Control Stud | 2002 |
Controlled assessment of beta2 adrenergic therapy for childhood asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Child; Choline; Clinical Trials as Topic; Double-Blind | 1978 |
Controlled assessment of oral bronchodilators for asthmatic children.
Topics: Administration, Oral; Adolescent; Asthma; Barbiturates; Bronchodilator Agents; Child; Clinical Trial | 1978 |
An evaluation of pharmacotherapy for exercise-induced asthma.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adult; Aerosols; Asthm | 1979 |
Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study.
Topics: Adolescent; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Colorado; Cromolyn Sodium; Dru | 1977 |
Theophylline and cromoglycate (cromolyn) in asthma.
Topics: Asthma; Chronic Disease; Clinical Trials as Topic; Cromolyn Sodium; Drug Evaluation; Drug Therapy, C | 1977 |
Pharmacologic modification of induced asthma.
Topics: Adult; Airway Resistance; Asthma; Clinical Trials as Topic; Cyclic AMP; Drug Synergism; Ephedrine; F | 1976 |
A comparison of a theophylline-ephedrine combination with terbutaline.
Topics: Adult; Asthma; Clinical Trials as Topic; Cyclic AMP; Drug Combinations; Ephedrine; Humans; Lung; Ter | 1978 |
[Ketotifen, a new prophylactic agent in asthma (author's transl)].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Asthma; Child; Female; Humans; Ketotifen; Male | 1979 |
Ephedrine therapy in asthmatic children. Clinical tolerance and absence of side effects.
Topics: Adolescent; Age Factors; Asthma; Child; Clinical Trials as Topic; Drug Therapy, Combination; Drug To | 1977 |
The effect of metaproterenol in chronic asthmatic children receiving therapeutic doses of theophylline.
Topics: Adolescent; Asthma; Child; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Meta | 1978 |
A comparison between effects of aminophylline, proxyphylline and terbutaline in asthmatics.
Topics: Adult; Aminophylline; Asthma; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evalu | 1977 |
The effectiveness of the short- and long-term use of crystallized theophylline in asthmatic children.
Topics: Administration, Oral; Adolescent; Asthma; Biological Availability; Child; Clinical Trials as Topic; | 1978 |
A sustained release theophylline preparation: efficacy in childhood asthma with low serum theophylline levels.
Topics: Administration, Oral; Adolescent; Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparatio | 1978 |
Bronchodilating effect of oral theophylline-ephedrine combination.
Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Dose-Response | 1978 |
Controlled comparison of Nuelin, Theodrox and Marax in asthmatic out-patients.
Topics: Adult; Aged; Aminophylline; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Combinations | 1978 |
The efficacy of oral theophylline and the combination of theophylline + hydroxyzine in chronic bronchial asthma.
Topics: Administration, Oral; Adult; Aged; Asthma; Chronic Disease; Clinical Trials as Topic; Double-Blind M | 1978 |
The effect of metaproterenol in chronic asthmatic children receiving therapeutic doses of theophylline.
Topics: Adolescent; Asthma; Child; Clinical Trials as Topic; Double-Blind Method; Female; Forced Expiratory | 1978 |
Bronchodilator effects of metaproterenol and oxtriphylline in asthma.
Topics: Asthma; Choline; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Forced Ex | 1978 |
Comparison of salbutamol and ephedrine in oral bronchodilator combinations with theophylline and hydroxyzine: their effects on asthmatics.
Topics: Administration, Oral; Albuterol; Asthma; Bronchodilator Agents; Circadian Rhythm; Clinical Trials as | 1977 |
Comparative bronchodilatory activity of cetiedil citrate monohydrate, theophylline, orciprenaline and placebo in adult asthmatics.
Topics: Adolescent; Adult; Aged; Asthma; Azepines; Bronchodilator Agents; Clinical Trials as Topic; Double-B | 1978 |
Tylophora indica in bronchial asthma (a controlled comparison with a standard anti-asthmatic drug).
Topics: Asthma; Clinical Trials as Topic; Ephedrine; Humans; Phenobarbital; Plants, Medicinal; Theophylline | 1978 |
[Cross-over double-blind study using neophylline oral (proxyphylline and diprophylline) in bronchial asthma].
Topics: Administration, Oral; Adult; Asthma; Clinical Trials as Topic; Drug Combinations; Female; Humans; Ma | 1979 |
Comparative pharmacokinetics of two theophylline derivatives in asthmatic patients.
Topics: Adult; Aminophylline; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; | 1979 |
[Long-term study on a new beta2-sympathicomimetic agent and a combination of an oral theophylline-ethylenediamine with retard effect and hexoprenaline (author's transl)].
Topics: Adult; Airway Resistance; Asthma; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparati | 1979 |
[Bronchospasmolytic effect of reproterol as aerosol (author's transl)].
Topics: Aerosols; Aged; Airway Resistance; Asthma; Blood Pressure; Bronchitis; Bronchodilator Agents; Chroni | 1979 |
Objective and subjective assessment of ephedrine combinations in asthmatic outpatients.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Asthma; Clinical Trials as Topic; Double-Blind Method; Dru | 1979 |
Theophylline-7-acetic acid: lack of absorption and therapeutic effectiveness.
Topics: Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Intestinal Absorption; | 1979 |
Assessment of oral antiasthmatic drugs by inhalation challenges.
Topics: Adult; Allergens; Asthma; Bronchial Provocation Tests; Choline; Clinical Trials as Topic; Double-Bli | 1979 |
A comparison of oral choline theophyllinate and beclomethasone in severe perennial asthma in children.
Topics: Administration, Oral; Aerosols; Asthma; Beclomethasone; Child; Child, Preschool; Clinical Trials as | 1979 |
Relationship of serum theophylline concentration to inhibition of exercise-induced bronchospasm and comparison with cromolyn.
Topics: Adolescent; Asthma; Bronchial Spasm; Child; Clinical Trials as Topic; Cromolyn Sodium; Female; Human | 1977 |
Pharmacodynamic and spirometric responses to a sustained-release theophylline capsule.
Topics: Adult; Asthma; Delayed-Action Preparations; Female; Forced Expiratory Volume; Humans; Kinetics; Male | 1979 |
[Lung function studies with the bronchodilator terbutaline].
Topics: Adult; Aged; Airway Resistance; Asthma; Atropine; Clenbuterol; Drug Combinations; Ethylenediamines; | 1979 |
Comparison of Theolair SR and Theo-Dur tablets.
Topics: Absorption; Asthma; Child; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; T | 1979 |
[The bronchospasmolytics salbutamol, fenoterol, terbutaline and reproterol. Their effects and side effects in asthmatics after inhalation with an electric nebulizer].
Topics: Adult; Aged; Albuterol; Asthma; Bronchodilator Agents; Female; Fenoterol; Humans; Hypoxia; Male; Met | 1978 |
[Do plasma theophylline levels condemn enteral forms].
Topics: Administration, Oral; Asthma; Humans; Suppositories; Theophylline | 1978 |
The efficacy of Neo-Biphyllin Retard in asthmatic patients--a theophylline slow-releasing coated tablet.
Topics: Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Humans; Respiration; Tablets, Enteric | 1976 |
Double-blind trial of a long-acting bronchodilator preparation ("Nethaprin Dospan") in bronchospastic disease.
Topics: Asthma; Bronchial Spasm; Bronchiectasis; Bronchitis; Bronchodilator Agents; Child; Clinical Trials a | 1976 |
Suppression of exercise-induced asthma by salbutamol, theophylline, atropine, cromolyn, and placebo in a group of asthmatic children.
Topics: Adolescent; Albuterol; Asthma; Atropine; Child; Child, Preschool; Cromolyn Sodium; Female; Humans; M | 1975 |
An evaluation of theophylline/ephedrine with and without hydroxyzine in asthma.
Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Eph | 1975 |
Inhibition of exercise-induced asthma by different pharmacological pathways.
Topics: Adolescent; Airway Obstruction; Albuterol; Asthma; Atropine Derivatives; Bronchodilator Agents; Chil | 1976 |
[A multi-centre study of reproterol, a bronchodilator (author's transl)].
Topics: Airway Resistance; Asthma; Blood Pressure; Bronchitis; Drug Combinations; Drug Evaluation; Female; H | 1977 |
[Kenacort a solubile in status asthmaticus and acute asthmatic attack (author's transl)].
Topics: Asthma; Drug Evaluation; Drug Therapy, Combination; Humans; Injections, Intravenous; Theophylline; T | 1976 |
Interaction of ephedrine and theophylline.
Topics: Adolescent; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Drug Combinations; Drug Inter | 1975 |
Exercise-induced asthma. Pharmacological assessment of single drugs and drug combinations.
Topics: Adolescent; Age Factors; Asthma; Child; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Com | 1975 |
The pharmacological assessment of single drugs and drug combinations in exercise-induced asthma.
Topics: Adolescent; Asthma; Child; Clinical Trials as Topic; Drug Combinations; Ephedrine; Forced Expiratory | 1975 |
[Effect of ofloxacin, ciprofloxacin and nalidixic acid on serum theophylline level in patients treated with methylxanthine preparations].
Topics: Administration, Oral; Adult; Aminophylline; Asthma; Biological Availability; Ciprofloxacin; Drug The | 1992 |
Effects of the addition of nedocromil sodium to maintenance bronchodilator therapy in the management of chronic asthma.
Topics: Adolescent; Adult; Aerosols; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchodilator Agents; | 1992 |
Theophylline inhibits late asthmatic reactions induced by toluene diisocyanate in sensitised subjects.
Topics: Administration, Inhalation; Administration, Oral; Analysis of Variance; Asthma; Bronchial Provocatio | 1992 |
Formoterol, a new long-acting beta 2 agonist, inhaled twice daily, in stable asthmatic subjects.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Aerosols; Albuterol; Asthma; Bronchodilator Ag | 1992 |
[Salmeterol and prolonged treatment of asthma: international clinical data].
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Double-Blind Method; Drug Tole | 1992 |
[Usefulness of salmeterol in nocturnal asthma: a comparative study with theophylline-ketotifen association. A French multicenter group].
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Double-Blind Method; Drug Ther | 1992 |
Which patients benefit from adding theophylline to beta 2-agonist treatment in severe acute asthma?
Topics: Acute Disease; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Female; Humans; Male; Middl | 1992 |
Salmeterol versus slow-release theophylline combined with ketotifen in nocturnal asthma: a multicentre trial. French Multicentre Study Group.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Albuterol; Asthma; Bronch | 1992 |
Stability of the circadian alteration in lung function in asthma.
Topics: Adult; Asthma; Bronchial Provocation Tests; Circadian Rhythm; Forced Expiratory Volume; Humans; Lung | 1992 |
Theophylline mitigates the bronchoconstrictor effects of sulfur dioxide in subjects with asthma.
Topics: Adolescent; Adult; Asthma; Bronchoconstrictor Agents; Delayed-Action Preparations; Double-Blind Meth | 1992 |
Effect of low-dose troleandomycin on theophylline clearance: implications for therapeutic drug monitoring.
Topics: Adolescent; Asthma; Child; Double-Blind Method; Drug Administration Schedule; Drug Monitoring; Femal | 1992 |
Theophylline-induced behavior change in children. An objective evaluation of parents' perceptions.
Topics: Affect; Asthma; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Doub | 1992 |
Bronchodilator intake and plasma levels on admission for severe acute asthma.
Topics: Acute Disease; Administration, Inhalation; Adult; Aged; Albuterol; Asthma; Blood Pressure; Dose-Resp | 1992 |
Asthma morbidity in Australia: an epidemiological study.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Asthma; Australia; Bronchodilator Agents | 1992 |
Once-a-day dosing with theophylline: a comparison of four sustained-release products.
Topics: Adolescent; Adult; Aged; Asthma; Circadian Rhythm; Delayed-Action Preparations; Drug Administration | 1992 |
[Use of intravenous adrenalin in severe acute asthma].
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Asthma; Blood Gas Analysis; Blood Pressure; Drug Ther | 1992 |
Long-term comparison of three combinations of albuterol, theophylline, and beclomethasone in children with chronic asthma.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Albuterol; Asthma; Beclomethasone; Chi | 1992 |
Evaluation of a once-a-day theophylline preparation in asthmatic children.
Topics: Asthma; Child; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Male; Theo | 1992 |
Repeated dosing of Uniphyl tablets under fed and fasting conditions: comparison of serum theophylline levels, pulmonary function, and asthma symptoms.
Topics: Aged; Asthma; Dose-Response Relationship, Drug; Eating; Fasting; Female; Forced Expiratory Volume; H | 1991 |
Psychological change associated with theophylline treatment of asthmatic children: a 6-month study.
Topics: Affective Symptoms; Asthma; Child; Child Behavior Disorders; Female; Humans; Intelligence Tests; Mal | 1991 |
[Delayed-release salbutamol, a new beta-mimetic with prolonged action. Results of a comparative study against theophylline L.A].
Topics: Adolescent; Aged; Albuterol; Asthma; Delayed-Action Preparations; Female; Humans; Male; Maximal Expi | 1991 |
[The clinical efficacy and pharmacokinetic characteristics of theopek and theobiolong in bronchial asthma patients].
Topics: Adult; Asthma; Delayed-Action Preparations; Drug Tolerance; Female; Humans; Tablets; Theophylline; T | 1991 |
[24-hour lung function in asthmatic patients: chrono-optimal theophylline therapy as once-daily Euphylong administration vs conventional twice-daily administration].
Topics: Adult; Asthma; Circadian Rhythm; Female; Humans; Lung Volume Measurements; Male; Middle Aged; Theoph | 1991 |
[Efficacy of a theophylline retard preparation administered at 3 different intake times additionally to basic medication].
Topics: Adult; Aged; Asthma; Circadian Rhythm; Female; Humans; Male; Middle Aged; Parasympatholytics; Peak E | 1991 |
Nifedipine alters serum theophylline levels in asthmatic patients with hypertension.
Topics: Adult; Asthma; Blood Pressure; Double-Blind Method; Drug Interactions; Female; Humans; Hypertension; | 1991 |
Effect of a new quinolone, sparfloxacin, on the pharmacokinetics of theophylline in asthmatic patients.
Topics: 4-Quinolones; Aged; Anti-Infective Agents; Asthma; Biological Availability; Chromatography, High Pre | 1991 |
A double-blind placebo-controlled trial of theophylline in general practice.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Clinical Protocols; Double-Blind Method; Family Practice; Fe | 1991 |
The effect of sustained-release theophylline in nocturnal asthma.
Topics: Adult; Asthma; Bronchodilator Agents; Delayed-Action Preparations; Double-Blind Method; Drug Evaluat | 1991 |
[Randomized and controlled single-case study--a scientific method for individual and difficult therapy decisions in clinical practice exemplified with methotrexate use in asthma].
Topics: Adult; Asthma; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Methotrexate; Prednis | 1991 |
[Slow-release salbutamol in the treatment of nocturnal asthma. Result of a comparative study vs. long-acting theophylline].
Topics: Adult; Albuterol; Asthma; Circadian Rhythm; Delayed-Action Preparations; Double-Blind Method; Drug E | 1991 |
Sleep quality in children with asthma treated with theophylline or cromolyn sodium.
Topics: Adolescent; Asthma; Child; Cromolyn Sodium; Double-Blind Method; Female; Humans; Male; Sleep; Theoph | 1991 |
Effects of a combined treatment theophylline and tulobuterol on nocturnal chronic asthma.
Topics: Adrenergic beta-Agonists; Adult; Aged; Asthma; Bronchodilator Agents; Double-Blind Method; Drug Admi | 1990 |
[A second drug in nonatopic asthma insufficiently controlled with beta 2-adrenergic stimulants: budesonide versus theophylline].
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Asthma; Bronchodilator Agents; Budesonide; Double | 1990 |
Controlled trial of a home and ambulatory program for asthmatic children.
Topics: Adolescent; Air Pollutants; Ambulatory Care; Asthma; Child; Family; Female; Home Care Services; Huma | 1991 |
Effect of therapeutic plasma concentrations of theophylline on behavior, cognitive processing, and affect in children with asthma.
Topics: Affect; Asthma; Attention; Child; Child Behavior; Cognition; Double-Blind Method; Female; Forced Exp | 1991 |
Theophylline inhibits early and late asthmatic reactions induced by allergens in asthmatic subjects.
Topics: Administration, Oral; Adolescent; Adult; Allergens; Asthma; Bronchial Provocation Tests; Delayed-Act | 1991 |
Theophylline analysis at the chest clinic--comparison of a portable versus conventional system.
Topics: Adult; Aged; Asthma; Chromatography, High Pressure Liquid; Economics, Medical; Female; Humans; Male; | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Inhaled epinephrine and oral theophylline-ephedrine in the treatment of asthma.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Double-Blind Method; Drug Therapy, | 1991 |
Manufacturer's information insert and subjective theophylline side-effects.
Topics: Adult; Asthma; Drug Labeling; Female; Humans; Male; Middle Aged; Theophylline; Treatment Refusal | 1990 |
The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients.
Topics: Adult; Aminophylline; Asthma; Double-Blind Method; Duodenal Ulcer; Female; Gastric Acid; Gastric Jui | 1990 |
A clinical and immunologic study of colchicine in asthma.
Topics: Adolescent; Adult; Albuterol; Asthma; Bronchial Provocation Tests; Chronic Disease; Colchicine; Conc | 1990 |
A double-blind multicenter group comparative study of the efficacy and safety of nedocromil sodium in the management of asthma. North American Tilade Study Group.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchodilator Agents; Delayed-Action Prepar | 1990 |
High-dose inhaled versus intravenous salbutamol combined with theophylline in severe acute asthma. Swedish Society of Chest Medicine.
Topics: Administration, Inhalation; Albuterol; Asthma; Drug Therapy, Combination; Female; Humans; Infusions, | 1990 |
Efficacy of sustained release theophylline given at three different evening intake times in addition to a baseline medication.
Topics: Asthma; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Male; Middle Aged | 1990 |
Long-term, double-blind comparison of controlled-release albuterol versus sustained-release theophylline in adolescents and adults with asthma.
Topics: Adolescent; Adult; Albuterol; Asthma; Capsules; Delayed-Action Preparations; Double-Blind Method; Hu | 1990 |
Relationship of different serum levels of theophylline on methacholine sensitivity.
Topics: Adult; Asthma; Bronchial Provocation Tests; Drug Administration Schedule; Female; Forced Expiratory | 1990 |
Twenty-four hour lung function in adult patients with asthma. Chronoptimized theophylline therapy once-daily dosing in the evening versus conventional twice-daily dosing.
Topics: Adult; Asthma; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedule; Female; | 1990 |
Nocturnal oxygen saturation and body movement in asthmatics treated with controlled-release preparations of theophylline or terbutaline.
Topics: Adult; Asthma; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Middle Aged; | 1990 |
Once-daily theophylline in the treatment of nocturnal asthma.
Topics: Adolescent; Adult; Aged; Asthma; Delayed-Action Preparations; Double-Blind Method; Drug Administrati | 1990 |
Comparison between theophylline and an adenosine non-blocking xanthine in acute asthma.
Topics: Acute Disease; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Asthma; Bronchodilator Agents; Double- | 1990 |
[Effect of nebulized salbutamol in 26 patients hospitalized for asthma attack].
Topics: Adult; Albuterol; Asthma; Drug Tolerance; Female; Hospitalization; Humans; Injections, Intravenous; | 1990 |
Home monitoring of theophylline levels: a novel therapeutic approach.
Topics: Ambulatory Care; Asthma; Female; Humans; Lung Diseases; Lung Diseases, Obstructive; Male; Monitoring | 1990 |
Arrhythmogenicity from combined bronchodilator therapy in patients with obstructive lung disease and concomitant ischemic heart disease.
Topics: Aged; Asthma; Bronchitis; Cardiac Complexes, Premature; Clinical Trials as Topic; Coronary Disease; | 1987 |
Theophylline does not inhibit allergen-induced increase in airway responsiveness to methacholine.
Topics: Adult; Airway Resistance; Allergens; Asthma; Bronchial Provocation Tests; Cromolyn Sodium; Female; F | 1989 |
[Effectiveness of various inhalation aids in children with bronchial asthma].
Topics: Adolescent; Asthma; Bronchodilator Agents; Child; Cromolyn Sodium; Drug Combinations; Humans; Metapr | 1989 |
[Clinico-laboratory evaluation a new sustained-release preparation of anhydrous theophylline].
Topics: Adult; Aged; Asthma; Bronchitis; Delayed-Action Preparations; Female; Humans; Lung Diseases, Obstruc | 1989 |
Reassessment of mast cell stabilizers in the treatment of respiratory disease.
Topics: Adrenal Cortex Hormones; Adult; Animals; Asthma; Child; Clinical Trials as Topic; Cromolyn Sodium; H | 1989 |
[Nedocromil sodium therapy in asthma patients. Therapeutic effect in addition to treatment with oral theophylline and inhaled bronchodilator agents].
Topics: Administration, Inhalation; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchodil | 1989 |
The protective effects of intravenous theophylline and enprofylline against histamine- and adenosine 5'-monophosphate-provoked bronchoconstriction: implications for the mechanisms of action of xanthine derivatives in asthma.
Topics: Adult; Allergens; Asthma; Bronchoconstriction; Bronchodilator Agents; Cyclic AMP; Female; Forced Exp | 1989 |
The reducing effects of tazifylline on histamine-induced bronchoconstriction in atopic asthmatics.
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Histamine; Histamine H1 Antagonists; Humans; Male; | 1989 |
[Combination of theophylline and beta-adrenergic agonists in the treatment of asthma: efficacy and tolerance. Review of the literature].
Topics: Acute Disease; Adrenergic beta-Agonists; Arrhythmias, Cardiac; Asthma; Bronchi; Drug Therapy, Combin | 1989 |
Long-term oral therapy of asthma with terbutaline and theophylline, alone and combined.
Topics: Administration, Oral; Adolescent; Adult; Aged; Akathisia, Drug-Induced; Arrhythmias, Cardiac; Asthma | 1985 |
Nocturnal asthma therapy. Inhaled bitolterol versus sustained-release theophylline.
Topics: Administration, Inhalation; Administration, Oral; Asthma; Bronchodilator Agents; Clinical Trials as | 1989 |
Aminophylline loading in asthmatic patients: a protocol trial.
Topics: Adolescent; Adult; Aged; Aging; Aminophylline; Asthma; Body Weight; Clinical Trials as Topic; Emerge | 1989 |
Slow-release terbutaline and theophylline for the long-term therapy of children with asthma: a Latin square and factorial study of drug effects and interactions.
Topics: Adolescent; Analysis of Variance; Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparatio | 1989 |
A Canadian multicenter study with Zaditen (ketotifen) in the treatment of bronchial asthma in children aged 5 to 17 years.
Topics: Adolescent; Asthma; Bronchospirometry; Canada; Child; Child, Preschool; Clinical Trials as Topic; Do | 1989 |
Effect of theophylline on airway responses to inhaled platelet-activating factor in man.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Double-Blind Method; Female; Humans; Ma | 1989 |
Once or twice daily theophylline in childhood asthma.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans | 1989 |
Efficacy and pharmacokinetics of slow release theophylline in preschool children with intermittent episodes of asthma.
Topics: Asthma; Child, Preschool; Delayed-Action Preparations; Female; Humans; Infant; Male; Randomized Cont | 1989 |
[Treatment of nocturnal bronchial asthma].
Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Metho | 1989 |
Effect of theophylline and enprofylline on bronchial hyperresponsiveness.
Topics: Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Bronchodilator Agents; Doubl | 1989 |
Day-night differences in steady-state theophylline pharmacokinetics in asthmatic children.
Topics: Administration, Oral; Adolescent; Asthma; Child; Circadian Rhythm; Delayed-Action Preparations; Fema | 1989 |
Effect of theophylline and salbutamol on hepatic drug metabolism.
Topics: Adult; Albuterol; Antipyrine; Asthma; Coffee; Female; Humans; Liver; Male; Middle Aged; Respiratory | 1989 |
Protective effect of antiasthma drugs on late asthmatic reactions and increased airway responsiveness induced by toluene diisocyanate in sensitized subjects.
Topics: Asthma; Beclomethasone; Bronchial Provocation Tests; Clinical Trials as Topic; Cromolyn Sodium; Cyan | 1987 |
Combination therapy of theophylline and terbutaline as sustained-release preparations in patients with asthmatic bronchitis.
Topics: Adult; Asthma; Cyclic AMP; Delayed-Action Preparations; Double-Blind Method; Drug Evaluation; Drug T | 1987 |
Evaluation of reproterol's effectiveness in preventing exercise-induced bronchospasm in children.
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Child; | 1985 |
Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aerosols; Aminophylline; Asthma; Drug Therapy, Combinat | 1985 |
Cardiac arrhythmias during the combined use of beta-adrenergic agonist drugs and theophylline.
Topics: Adrenergic beta-Agonists; Adult; Arrhythmias, Cardiac; Asthma; Clinical Trials as Topic; Drug Therap | 1986 |
Treatment of asthma with an extempore combination of a bronchodilator, salbutamol, and a new antihistamine drug, oxatomide.
Topics: Adrenal Cortex Hormones; Adult; Aged; Albuterol; Asthma; Clinical Trials as Topic; Drug Combinations | 1986 |
Twice-daily beclomethasone dipropionate in the treatment of childhood asthma.
Topics: Adrenergic beta-Agonists; Asthma; Beclomethasone; Child; Double-Blind Method; Drug Administration Sc | 1986 |
Theophylline in maintenance treatment of chronic asthma: concentration-dependent additional effect to beta 2-agonist therapy.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Chronic Disease; Clinical Trials as Topic; | 1987 |
The effect of theophylline and beta 2 agonists on airway reactivity.
Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchial Provocation Test | 1987 |
Theophylline as a bronchodilator in COPD and its combination with inhaled beta-adrenergic drugs.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Asthma; Bronchi; Bronchitis; Clinical Trials as Topic; | 1987 |
Ipratropium.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Asthma; Atropine Derivatives; Clinical Trials | 1987 |
Comparative trials including a beta 2 adrenergic agonist, a methylxanthine, and a mast cell stabilizer.
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Attention; Child; Cromolyn Sodium; Dose-Response Relati | 1988 |
Effect of theophylline on gastroesophageal reflux in patients with asthma.
Topics: Adrenergic beta-Agonists; Adult; Aged; Asthma; Double-Blind Method; Female; Gastroesophageal Reflux; | 1988 |
Can mild bronchospasm reduce gastroesophageal reflux?
Topics: Aged; Asthma; Bronchial Provocation Tests; Esophagogastric Junction; Female; Forced Expiratory Volum | 1989 |
Circadian variations in theophylline concentrations and the treatment of nocturnal asthma.
Topics: Adult; Asthma; Circadian Rhythm; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug | 1989 |
Effects of theophylline on behavior and learning in children with asthma.
Topics: Asthma; Attention; Child; Child Behavior; Double-Blind Method; Female; Humans; Male; Memory; Motor A | 1989 |
Increased theophylline clearance in asthmatic patients due to terbutaline.
Topics: Adult; Asthma; Delayed-Action Preparations; Drug Interactions; Female; Humans; Male; Middle Aged; Te | 1989 |
Comparison between steady state pharmacokinetics and effects of two once-daily, slow-release theophylline formulations in nocturnal asthma.
Topics: Adult; Asthma; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Middle Aged; | 1988 |
A group comparative study of the safety and efficacy of nedocromil sodium (Tilade) in reversible airways disease: a preliminary report.
Topics: Adrenal Cortex Hormones; Adult; Aerosols; Asthma; Circadian Rhythm; Clinical Trials as Topic; Double | 1986 |
Lung function improvement, tremor measurements and c-AMP determinations in a group of ten patients with asthmatic bronchitis after one week sustained release theophylline medication (theophylline plasma level +/- 10 mg/l) compared to one week placebo.
Topics: Asthma; Bronchitis; Cyclic AMP; Delayed-Action Preparations; Female; Humans; Male; Respiratory Funct | 1986 |
Multicenter comparison of once-daily Uniphyl tablets administered in the morning or evening with baseline twice-daily theophylline therapy in patients with nocturnal asthma.
Topics: Adult; Asthma; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Drug Adminis | 1988 |
Is a uniform round-the-clock theophylline blood level necessary for optimal asthma therapy in the adolescent patient?
Topics: Adolescent; Asthma; Child; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; | 1988 |
Improved control of asthma in the office setting. A large-scale study of once-daily evening doses of theophylline.
Topics: Adult; Asthma; Circadian Rhythm; Clinical Trials as Topic; Drug Administration Schedule; Female; Hum | 1988 |
Safety and efficacy of once-daily Uniphyl tablets compared with twice-daily Theo-Dur tablets in elderly patients with chronic airflow obstruction.
Topics: Aged; Asthma; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind M | 1988 |
A controlled trial of an oral bronchodilator preparation ('Franol') in asthma.
Topics: Administration, Oral; Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Clinical Trials as Top | 1988 |
Steady-state evaluation of two controlled-release theophylline preparations in children.
Topics: Absorption; Adolescent; Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparations; Female | 1988 |
Oral bioavailability of slow-release theophylline from unencapsulated beads in preschool children with chronic asthma.
Topics: Administration, Oral; Asthma; Biological Availability; Child; Child, Preschool; Chronic Disease; Cli | 1988 |
A double-blind, placebo-controlled comparison of the efficacy of standard and individually titrated doses of theophylline in patients with chronic asthma.
Topics: Adult; Aged; Asthma; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations; Double- | 1988 |
Comparison of the effect of oxitropium bromide and of slow-release theophylline on nocturnal asthma.
Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Metho | 1988 |
[Theophylline in the serum and bronchoalveolar lavage fluid (BALF) in patients with bronchospastic conditions].
Topics: Adult; Asthma; Bronchitis; Bronchoalveolar Lavage Fluid; Clinical Trials as Topic; Double-Blind Meth | 1988 |
A study comparing Pro-Vent and phyllocontin in stable asthmatics.
Topics: Adolescent; Adult; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Metho | 1988 |
[Intravenous infusion of reproterol (a beta-2-mimetic agent) in the therapy of severe asthma attacks in childhood].
Topics: Adolescent; Albuterol; Asthma; Bronchodilator Agents; Carbon Dioxide; Child; Child, Preschool; Combi | 1986 |
Cognitive and behavioral findings in children taking theophylline.
Topics: Asthma; Attention; Behavior; Child; Cognition; Cromolyn Sodium; Female; Humans; Male; Theophylline | 1988 |
Double-blind crossover study comparing sodium cromoglycate, reproterol, reproterol plus sodium cromoglycate, and placebo in exercise-induced asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchodilator Agen | 1988 |
Comparison of the oral and intravenous routes for treating asthma with methylprednisolone and theophylline.
Topics: Acute Disease; Administration, Oral; Aged; Asthma; Delayed-Action Preparations; Drug Therapy, Combin | 1988 |
A steady state comparison of three theophylline formulations in adult stable asthmatics.
Topics: Adult; Aminophylline; Asthma; Biological Availability; Bronchodilator Agents; Choline; Excipients; F | 1988 |
Acute dosing with methylprednisolone in normal subjects does not affect theophylline clearance.
Topics: Administration, Oral; Adult; Asthma; Drug Therapy, Combination; Female; Humans; Male; Methylpredniso | 1988 |
Theophylline minimally inhibits bronchoconstriction induced by dry cold air inhalation in asthmatic subjects.
Topics: Adolescent; Adult; Aged; Asthma; Bronchial Spasm; Cold Temperature; Delayed-Action Preparations; Dou | 1988 |
[Clinical use of theophylline retard Oranienburg].
Topics: Adrenal Cortex Hormones; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Dose-Respons | 1988 |
Nocturnal asthma: slow-release terbutaline versus slow-release theophylline therapy.
Topics: Adult; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; H | 1988 |
A dose-response study of the bronchodilator action of azelastine in asthma.
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Child; Clinical Trials as Topic; Dose-Response Rel | 1987 |
The effects of theophylline on airway inflammation.
Topics: Adult; Animals; Anti-Inflammatory Agents; Asthma; Bronchi; Bronchial Provocation Tests; Bronchitis; | 1987 |
Theophylline and mucociliary clearance.
Topics: Aminophylline; Animals; Asthma; Bronchitis; Cilia; Clinical Trials as Topic; Dogs; Humans; Lung Dise | 1987 |
School performance and theophylline.
Topics: Asthma; Child; Child Behavior; Clinical Trials as Topic; Humans; Schools; Statistics as Topic; Theop | 1987 |
[Polysomnographic measurements in early and late administration (18.00 vs. 22.00 hours) of retarded theophylline in bronchial asthma].
Topics: Adult; Airway Resistance; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Drug Admini | 1987 |
Therapeutic advantage of unequal dosing of theophylline in patients with nocturnal asthma.
Topics: Adult; Aged; Asthma; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Drug A | 1987 |
Chrono-optimization of the time of evening administration with unequally divided twice-daily theophylline.
Topics: Adult; Aged; Asthma; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Drug A | 1987 |
Treatment of asthma by a controlled-release theophylline tablet formulation: a review of the North American experience with nocturnal dosing.
Topics: Asthma; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Drug Administration | 1987 |
Treatment of nocturnal asthma: the role of sustained-release theophylline and oral beta-2-mimetics.
Topics: Adult; Asthma; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind | 1987 |
Comparison of once-daily evening versus morning sustained-release theophylline dosing for nocturnal asthma.
Topics: Adult; Asthma; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind | 1987 |
Comparison of sustained-release theophylline scheduled conventionally (twice-daily, equal interval in equal amount) versus once-daily mornings or evenings on circadian pattern of bronchial patency in asthmatics.
Topics: Adult; Asthma; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind | 1987 |
Administration-time-dependency of the pharmacokinetic behavior and therapeutic effect of a once-a-day theophylline in asthmatic children.
Topics: Asthma; Child; Circadian Rhythm; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind | 1987 |
A once daily theophylline preparation in prevention of nocturnal symptoms in childhood asthma.
Topics: Adolescent; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Delayed-Action Preparations; | 1987 |
Effect of nifedipine on serum theophylline concentrations and asthma control.
Topics: Aged; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Huma | 1987 |
[Prescription of Theostat 300 as a single evening dose].
Topics: Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Drug Administration Schedule; Female; | 1987 |
[Therapy of nocturnal bronchial asthma: comparison of various doses of retard theophylline].
Topics: Adult; Aged; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Dose-Response Relationsh | 1987 |
Methylxanthines inhibit exercise-induced bronchoconstriction at low serum theophylline concentration and in a dose-dependent fashion.
Topics: Adolescent; Adult; Air; Asthma; Asthma, Exercise-Induced; Breathing Exercises; Cold Temperature; Dos | 1988 |
Clinical relevance of the substitution of different brands of sustained-release theophylline.
Topics: Adult; Asthma; Biological Availability; Delayed-Action Preparations; Dose-Response Relationship, Dru | 1988 |
Need for theophylline in severe steroid-requiring asthmatics.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Child; Female; Forced Expiratory Volume; Humans; Male; | 1988 |
Clinical and pharmacokinetic evaluation of a sustained-release liquid theophylline preparation.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Forced Expiratory Volume; Humans; Theo | 1988 |
Relationship of serum theophylline concentrations to histamine-induced bronchospasm.
Topics: Administration, Inhalation; Adolescent; Adult; Asthma; Bronchial Spasm; Double-Blind Method; Female; | 1987 |
Treatment of acute asthma. Is combination therapy with sympathomimetics and methylxanthines indicated?
Topics: Acute Disease; Adolescent; Adult; Aminophylline; Asthma; Clinical Trials as Topic; Drug Therapy, Com | 1986 |
Once daily theophylline in childhood asthma.
Topics: Asthma; Child; Child, Preschool; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind | 1986 |
Comparison study of sustained-release theophylline products: Slo-bid capsules versus Theo-Dur tablets in 20 children and young adults with asthma.
Topics: Adolescent; Adult; Asthma; Biological Availability; Child; Clinical Trials as Topic; Delayed-Action | 1986 |
Sustained-release theophylline preparations in asthmatic children. A short-term comparison of two products and the relationship of serum theophylline levels and pulmonary function changes.
Topics: Adolescent; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations; D | 1986 |
Comparison of enprofylline and theophylline for intravenous treatment of acute asthma.
Topics: Acute Disease; Adult; Aged; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Female; Humans; | 1986 |
Protective effect of theophylline on histamine-induced bronchoconstriction in asthmatic children.
Topics: Adolescent; Asthma; Bronchi; Child; Child, Preschool; Clinical Trials as Topic; Histamine; Humans; P | 1986 |
Effect of ketotifen on the bronchodilating action of aminophylline.
Topics: Adolescent; Adult; Aminophylline; Asthma; Bronchi; Clinical Trials as Topic; Double-Blind Method; Dr | 1986 |
Enprofylline and theophylline slow-eroding tablets in the treatment of asthma: a comparison.
Topics: Adult; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Headache; | 1986 |
Addition of terbutaline to optimal theophylline therapy. Double blind crossover study in asthmatic patients.
Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Asthma; Child; Clinical T | 1986 |
Comparison of oral salbutamol with reproterol in reversible airway obstruction.
Topics: Administration, Oral; Adolescent; Adult; Albuterol; Asthma; Bronchitis; Bronchodilator Agents; Clini | 1986 |
[Clinico-functional study of the activity of a new xanthine derivative: bamifylline].
Topics: Adult; Aged; Aminophylline; Asthma; Bronchodilator Agents; Bronchopneumonia; Chronic Disease; Clinic | 1986 |
Comparison of two new controlled-release theophylline formulations in the management of asthma in children and reliability of salivary theophylline concentration.
Topics: Administration, Oral; Asthma; Biological Availability; Child; Child, Preschool; Clinical Trials as T | 1986 |
Bronchodilator effect of theophylline preparations and aerosol fenoterol in stable asthma.
Topics: Airway Resistance; Aminophylline; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Synerg | 1986 |
Once a day theophylline in chronic childhood asthma?
Topics: Adolescent; Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Metho | 1986 |
[A comparative study of Unixan administered once daily and Theo-Dur administered twice daily].
Topics: Adult; Aged; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Fem | 1986 |
Slow release theophylline in preschool asthmatics.
Topics: Asthma; Child, Preschool; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method | 1986 |
Extrapulmonary effects of maintenance therapy with theophylline and inhaled albuterol in patients with chronic asthma.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Albuterol; Asthma; Bicarbonates; Calcium; Chron | 1986 |
Intravenous aminophylline in patients already taking oral theophylline: effect on calculated dose of knowledge of serum theophylline concentration on admission.
Topics: Administration, Oral; Aminophylline; Asthma; Clinical Trials as Topic; Female; Humans; Injections, I | 1986 |
Theophylline plus hydroxyzine versus theophylline monohydrate in the treatment of asthma.
Topics: Adult; Asthma; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Humans; Hydroxyzine | 1986 |
[Comparative study of plasma levels of 2 delayed-action theophyllines: Theostat 200 and Theodur 200, after a single evening dose].
Topics: Adult; Asthma; Bronchitis; Delayed-Action Preparations; Double-Blind Method; Drug Administration Sch | 1986 |
Apparent inconsistent theophylline absorption from sustained release capsules.
Topics: Absorption; Asthma; Capsules; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; | 1987 |
Non-interaction of ketotifen and theophylline in children with asthma--an acute study.
Topics: Adolescent; Asthma; Child; Drug Interactions; Half-Life; Hemodynamics; Humans; Ketotifen; Respirator | 1987 |
Efficacy of enprofylline, a new bronchodilating xanthine, in acute asthma.
Topics: Adult; Aged; Asthma; Blood Pressure; Bronchodilator Agents; Female; Heart Rate; Humans; Male; Middle | 1987 |
A new sustained-release theophylline suspension for asthmatic children: evaluation of serum theophylline concentrations.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Humans; Theophylline | 1987 |
Inhaled corticosteroids reduce the severity of bronchial hyperresponsiveness in asthma but oral theophylline does not.
Topics: Adult; Aerosols; Airway Resistance; Asthma; Beclomethasone; Bronchi; Bronchial Provocation Tests; De | 1987 |
Serum drug fluctuations after administration of two sustained-release oral theophylline preparations in asthmatic children.
Topics: Administration, Oral; Adolescent; Asthma; Child; Chronic Disease; Delayed-Action Preparations; Doubl | 1986 |
Sustained-release terbutaline vs sustained-release theophylline in young patients with asthma.
Topics: Adolescent; Aerosols; Asthma; Child; Delayed-Action Preparations; Double-Blind Method; Female; Human | 1986 |
Effect of nifedipine and theophylline in asthma.
Topics: Adult; Aged; Animals; Asthma; Double-Blind Method; Drug Evaluation; Drug Interactions; Humans; Kinet | 1986 |
Methods of comparing pharmacokinetics of slow release preparations: a comparison of "Theo-Dur" and "Phyllocontin" in patients with asthma.
Topics: Adult; Aged; Asthma; Body Weight; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Middl | 1986 |
Effect of a methylxanthine preparation in the form of a retention enema on pulmonary function and theophylline levels in patients with acute bronchospasm.
Topics: Airway Resistance; Asthma; Bronchial Spasm; Enema; Female; Humans; Lung; Male; Middle Aged; Respirat | 1986 |
An open steady-state pharmacokinetic study to compare Pro-Vent and Phyllocontin in asthmatic patients.
Topics: Adult; Aminophylline; Asthma; Female; Humans; Kinetics; Male; Middle Aged; Theophylline | 1986 |
The use of a single daily theophylline dose and metered-dose albuterol in asthma treatment.
Topics: Adult; Albuterol; Asthma; Female; Forced Expiratory Volume; Humans; Male; Theophylline | 1986 |
Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma.
Topics: Aged; Asthma; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifedip | 1986 |
Behavior abnormalities and poor school performance due to oral theophylline use.
Topics: Achievement; Administration, Oral; Asthma; Attention; Child; Child Behavior; Delayed-Action Preparat | 1986 |
Relative efficacy of maintenance therapy with theophylline, inhaled albuterol, and the combination for chronic asthma.
Topics: Adolescent; Adult; Aged; Albuterol; Asthma; Chronic Disease; Drug Administration Schedule; Drug Ther | 1987 |
Once-daily sustained-release theophylline reduces diurnal variation in spirometry and symptomatology in adult asthmatics.
Topics: Adult; Asthma; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedule; Female; | 1987 |
Theo-Dur: no loss of sustained-release effect with chewing or crushing.
Topics: Adult; Asthma; Biological Availability; Delayed-Action Preparations; Female; Humans; Male; Random Al | 1985 |
Treatment of nocturnal asthma in children with a single dose of sustained-release theophylline taken after supper.
Topics: Adolescent; Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Metho | 1985 |
Nocturnal asthma: effect of a once per evening dose of sustained release theophylline.
Topics: Adult; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; H | 1985 |
Sustained-release theophylline preparations.
Topics: Absorption; Asthma; Bronchitis; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparatio | 1985 |
Sustained release theophylline in nocturnal asthma.
Topics: Asthma; Child; Clinical Trials as Topic; Humans; Research Design; Theophylline | 1985 |
Albuterol syrup in the treatment of asthma.
Topics: Albuterol; Asthma; Child; Child, Preschool; Clinical Trials as Topic; Drug Therapy, Combination; Ele | 1985 |
A multicenter trial of the prophylactic effect of ketotifen, theophylline, and placebo in atopic asthma.
Topics: Adolescent; Asthma; Clinical Trials as Topic; Female; Humans; Hypersensitivity, Immediate; Ketotifen | 1985 |
A comparative trial of the clinical efficacy and pharmacokinetics of 12-hour and 24-hour controlled release theophylline preparations in patients with chronic asthma.
Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparat | 1985 |
[Clinical study on the efficacy and tolerance in childhood of a new microgranule preparation of theophylline].
Topics: Asthma; Child; Clinical Trials as Topic; Delayed-Action Preparations; Drug Tolerance; Female; Humans | 1985 |
Comparison of intravenous and oral routes of theophylline loading in acute asthma.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Asthma; Clinical Trials as Topic; Female; Hu | 1985 |
The efficacy of sustained release theophylline (Pro-Vent), in asthma.
Topics: Adult; Aged; Asthma; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Fem | 1985 |
Effects of enprofylline and theophylline on exercise-induced asthma.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Clinical Trials as Topic; Double-Blind Method; | 1985 |
Bambuterol: effects of a new anti-asthmatic drug.
Topics: Adult; Aged; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Delayed-Action Preparations; D | 1985 |
Clinical, physiologic, and psychologic comparison of treatment by cromolyn or theophylline in childhood asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Cromolyn Sodium; Female; Humans; Male; Physi | 1985 |
Sustained release choline theophyllinate in nocturnal asthma.
Topics: Adult; Aged; Asthma; Choline; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Me | 1985 |
A multicenter study with ketotifen (Zaditen).
Topics: Administration, Oral; Asthma; Clinical Trials as Topic; Cromolyn Sodium; Double-Blind Method; Forced | 1985 |
[Comparison of the bronchodilator and protective effect of methylxanthines].
Topics: Adolescent; Adult; Aminophylline; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Dose-Resp | 1986 |
Albuterol protects against exercise-induced asthma longer than metaproterenol sulfate.
Topics: Adolescent; Albuterol; Asthma; Asthma, Exercise-Induced; Child; Female; Forced Expiratory Volume; Hu | 1986 |
Long-lasting protective effect of slow-release theophylline on asthma induced by ultrasonically nebulized distilled water.
Topics: Asthma; Bronchial Spasm; Delayed-Action Preparations; Forced Expiratory Volume; Humans; Male; Respir | 1986 |
Theophylline partially inhibits bronchoconstriction caused by inhaled histamine in subjects with asthma.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Female; Forced Expiratory Volume; | 1986 |
A comparative study of theophylline in a slow-release 'sprinkle' format with a standard syrup preparation in young children with asthma.
Topics: Absorption; Asthma; Child, Preschool; Delayed-Action Preparations; Dosage Forms; Evaluation Studies | 1986 |
Volume of distribution of theophylline in acute exacerbations of reversible airway disease. Effect of body weight.
Topics: Adolescent; Adult; Anthropometry; Asthma; Body Weight; Bronchial Spasm; Female; Humans; Kinetics; Ma | 1985 |
Reduction of serum theophylline levels by terbutaline in children with asthma.
Topics: Asthma; Blood Pressure; Child; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Do | 1985 |
Bronchodilator actions of xanthine derivatives administered by inhalation in asthma.
Topics: Adult; Aerosols; Aged; Airway Resistance; Aminophylline; Asthma; Bronchi; Dyphylline; Female; Forced | 1985 |
Specific antagonism of adenosine-induced bronchoconstriction in asthma by oral theophylline.
Topics: Adenosine; Adult; Airway Resistance; Asthma; Bronchi; Bronchodilator Agents; Female; Forced Expirato | 1985 |
[Pharmacokinetics and pharmacodynamics of proxyphylline in asthmatic children].
Topics: Administration, Oral; Adolescent; Aminophylline; Asthma; Bronchial Provocation Tests; Child; Delayed | 1985 |
The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma.
Topics: Adolescent; Asthma; Child; Female; Forced Expiratory Volume; Humans; Kinetics; Male; Theobromine; Th | 1985 |
Bronchial and cardiovascular responses to inhaled reproterol in asthmatics: a double-blind placebo controlled dose-response study.
Topics: Adult; Asthma; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinati | 1985 |
Pharmacokinetics and clinical response to single- and multiple-dose sustained-release theophylline compounds in perennial bronchial asthma.
Topics: Adult; Asthma; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Kinetics; | 1985 |
Comparison of morning and evening dosing with a 24-hour sustained-release theophylline, Uniphyl, for nocturnal asthma.
Topics: Adult; Appetite; Asthma; Circadian Rhythm; Drug Administration Schedule; Female; Heart Rate; Humans; | 1985 |
Comparison of morning versus evening dosing with a new once-daily oral theophylline formulation.
Topics: Adolescent; Adult; Asthma; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Fema | 1985 |
Theophylline and chlorpheniramine in childhood asthma. Dose requirements for children 6 to 12 years (therapeutic orphans) and young adults 13 to 18 years of age receiving cromolyn sodium prophylaxis.
Topics: Adolescent; Age Factors; Asthma; Bronchodilator Agents; Child; Chlorpheniramine; Clinical Trials as | 1974 |
Objective assessment of a bronchodilator drug combination in asthmatic outpatients.
Topics: Adolescent; Adult; Aerosols; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Drug Combinati | 1973 |
Oral aminophylline and dikydroxypropyl theophylline in reversible obstructive airway disease: a single-dose, double-blind, crossover comparison.
Topics: Administration, Oral; Adult; Aged; Airway Obstruction; Aminophylline; Asthma; Bronchial Spasm; Bronc | 1973 |
[Clinical pharmacology in the domain of pulmonology].
Topics: Acetylcholine; Adrenal Cortex Hormones; Aerosols; Antitussive Agents; Asthma; Bronchodilator Agents; | 1970 |
Clinical investigation of a new broncholyticum--decloxizine--as compared with franol and placebo treatment.
Topics: Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Clinical Trials as Topic; Ephedrine; Eth | 1970 |
[Clinical pharmacology in the domain of pulmonology].
Topics: Acetylcholine; Adrenal Cortex Hormones; Aerosols; Antitussive Agents; Asthma; Bronchodilator Agents; | 1970 |
An anti-asthmatic combination.
Topics: Adolescent; Adult; Aged; Asthma; Chlordiazepoxide; Clinical Trials as Topic; Drug Combinations; Ephe | 1972 |
Human and animal studies on the interactions between glyphylline and isoprenaline.
Topics: Aerosols; Aged; Airway Resistance; Animals; Asthma; Blood Pressure; Bronchi; Bronchodilator Agents; | 1972 |
Clinical effectiveness of commonly used oral bronchodilators in asthmatic children.
Topics: Administration, Oral; Adolescent; Asthma; Bronchodilator Agents; Child; Child, Preschool; Clinical T | 1973 |
Evaluation of oral bronchodilator therapy in asthmatic children. Bronchodilators in asthmatic children.
Topics: Administration, Oral; Aminophylline; Asthma; Bronchodilator Agents; Child; Clinical Trials as Topic; | 1974 |
[Critical evaluation of a long acting bronchodilator agent in the treatment of asthma and chronic bronchial diseases].
Topics: Asthma; Bronchial Diseases; Bronchodilator Agents; Chronic Disease; Clinical Trials as Topic; Drug C | 1973 |
A double-blind trial of 'nethaprin dospan' in chronic asthmatic children.
Topics: Administration, Oral; Asthma; Bronchodilator Agents; Clinical Trials as Topic; Delayed-Action Prepar | 1974 |
Bioavailability and efficacy of a sustained-release theophylline tablet.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Biological Availability; Clinical Trials as Topic; | 1974 |
Bronchodilator effect of oral salbutamol and an ephedrine+theophylline+hydroxyzine combination in asthmatic out-patients.
Topics: Adolescent; Adult; Albuterol; Asthma; Clinical Trials as Topic; Drug Combinations; Ephedrine; Female | 1974 |
Rational intravenous doses of theophylline.
Topics: Adolescent; Adult; Airway Obstruction; Aminophylline; Asthma; Dose-Response Relationship, Drug; Fema | 1973 |
Double-blind evaluation of an anti-asthmatic agent.
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Child; Clinical Trials as Topic; Female; Guaifenes | 1967 |
Two bronchodilator tablets compared with a placebo.
Topics: Asthma; Bronchodilator Agents; Clinical Trials as Topic; Humans; Piperazines; Placebos; Theophylline | 1967 |
A controlled evaluation of oral theophylline in asthmatic children.
Topics: Asthma; Capsules; Child; Clinical Trials as Topic; Drug Synergism; Epinephrine; Female; Guaifenesin; | 1968 |
Effects of theophylline-alcohol with potassium iodide in asthmatic patients.
Topics: Adult; Asthma; Clinical Trials as Topic; Cough; Dyspnea; Female; Humans; Male; Potassium Iodide; Res | 1969 |
Clinical pharmacology of bronchospasmolytics in the asthmatic.
Topics: Aerosols; Aminophylline; Asthma; Bronchial Spasm; Bronchodilator Agents; Clinical Trials as Topic; H | 1969 |
[Clinical-experimental trial of a bisolvon-ephedrine-theophylline-combination preparation for treatment of asthmatic dyspnea].
Topics: Adult; Aged; Asthma; Clinical Trials as Topic; Dyspnea; Ephedrine; Expectorants; Female; Humans; Mal | 1968 |
Theophylline and potassium iodide in the treatment of chronic asthma.
Topics: Adolescent; Adult; Asthma; Chronic Disease; Clinical Trials as Topic; Female; Humans; Iodides; Male; | 1969 |
Clinical trial of Theograd.
Topics: Aged; Asthma; Bronchitis; Clinical Trials as Topic; Delayed-Action Preparations; Female; Humans; Mal | 1970 |
[Objective subjective and biometric-chemical study of a combined antiasthmatic drug].
Topics: Aniline Compounds; Asthma; Biometry; Clinical Trials as Topic; Dexamethasone; Drug Synergism; Expect | 1971 |
Comparison of drugs for asthma.
Topics: 1-Propanol; Asthma; Clinical Trials as Topic; Humans; Placebos; Spirometry; Theophylline | 1971 |
[Oral therapy with germakellin--clinico-experimental studies].
Topics: Acetylcholine; Adult; Asthma; Bronchi; Clinical Trials as Topic; Female; Humans; Khellin; Male; Meth | 1970 |
Double-blind trial of aminophylline in status asthmaticus.
Topics: Adolescent; Adrenal Cortex Hormones; Aminophylline; Anti-Bacterial Agents; Asthma; Carbon Dioxide; C | 1971 |
Bronchodilator action of drug combinations in asthmatic patients. Ephedrine, theophylline and tranquilizing drugs.
Topics: Adolescent; Adult; Aged; Asthma; Barbiturates; Bronchodilator Agents; Clinical Trials as Topic; Drug | 1971 |
[Clinical comparison between terbutalin and proxiphyllin administered orally].
Topics: Administration, Oral; Amino Alcohols; Asthma; Bronchial Diseases; Female; Humans; Male; Pulmonary Ve | 1971 |
[Treatment of asthma with germakellin. Body plethysmographic investigations].
Topics: Airway Resistance; Asthma; Drug Synergism; Injections, Intravenous; Khellin; Plethysmography, Whole | 1971 |
Ephedrine and theophylline in asthmatic children: quantitive observations on the combination and ephedrine tachyphylaxis.
Topics: Asthma; Child; Clinical Trials as Topic; Ephedrine; Humans; Respiratory Function Tests; Tachyphylaxi | 1965 |
Respiratory function and clinical responses to theophylline guiaphenesin ("Entair").
Topics: Aged; Asthma; Bronchitis; Clinical Trials as Topic; Ephedrine; Humans; Isoproterenol; Middle Aged; T | 1966 |
A trial of proxyphylline in the treatment of chronic obstructive airways disease.
Topics: Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Female; Humans; Male; Middle Aged; Spiro | 1969 |
Pharmacologic effects of intravenously administered aminophylline in asthmatic children.
Topics: Adolescent; Aminophylline; Asthma; Blood Pressure; Child; Child, Preschool; Female; Heart Rate; Huma | 1970 |
The effect of oral theophylline on bronchospasm.
Topics: Administration, Oral; Adolescent; Adult; Aged; Asthma; Bronchial Spasm; Bronchodilator Agents; Child | 1971 |
[Therapy of asthmoid diseases with a secretolytically acting combination preparation].
Topics: Asthma; Bronchitis; Emphysema; Ephedrine; Expectorants; Humans; Quaternary Ammonium Compounds; Respi | 1967 |
1662 other studies available for theophylline and Asthma, Bronchial
| Article | Year |
|---|---|
Preparation of triazolo[1,5-c]pyrimidines as potential antiasthma agents.
Topics: Animals; Asthma; Chemical Phenomena; Chemistry; Female; Histamine H1 Antagonists; Mice; Passive Cuta | 1990 |
Imidazo[1,5-d][1,2,4]triazines as potential antiasthma agents.
Topics: Anaphylaxis; Animals; Asthma; Basophils; Chemical Phenomena; Chemistry; Guinea Pigs; Histamine Relea | 1985 |
The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.
Topics: Adenosine A2 Receptor Antagonists; Asthma; Drug Stability; Humans; Liver; Structure-Activity Relatio | 2005 |
Urinary caffeine and caffeine metabolites, asthma, and lung function in a nationwide study of U.S. adults.
Topics: Adult; Asthma; Bronchodilator Agents; Caffeine; Coffee; Cross-Sectional Studies; Humans; Lung; Nutri | 2022 |
Characteristics of medicine use for children with asthma in China: a nationwide population-based study.
Topics: Administration, Inhalation; Adolescent; Anti-Asthmatic Agents; Asthma; Child; Child, Preschool; Chin | 2022 |
Theophylline-Induced Relaxation Is Enhanced after Testosterone Treatment via Increased K
Topics: Animals; Asthma; Female; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; Sexual Maturation; Te | 2023 |
Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach.
Topics: Administration, Intravenous; Administration, Oral; Adult; Age Factors; Area Under Curve; Asthma; Chi | 2020 |
Lung Health Care pilot project trims patient pill load and antibiotic prescription in primary health care settings in Kerala, India.
Topics: Adult; Aged; Anti-Bacterial Agents; Asthma; Bronchodilator Agents; Dexamethasone; Female; Focus Grou | 2020 |
Treatment of ventilation failure after tracheal intubation due to asthma attack with high concentration sevoflurane.
Topics: Abscess; Adult; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Anus Dis | 2017 |
Asthma in Singapore: Past, Present and Future.
Topics: Adrenal Cortex Hormones; Albuterol; Arsenic Poisoning; Asthma; Bronchodilator Agents; Developed Coun | 2017 |
Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children.
Topics: Acute Disease; Administration, Intravenous; Adolescent; Asthma; Child; Child, Preschool; Female; Hum | 2018 |
Dr Elliot F. Ellis: Initiating personalized asthma management in children.
Topics: Adult; Anti-Asthmatic Agents; Asthma; Child; History, 20th Century; History, 21st Century; Humans; M | 2018 |
Population pharmacokinetics of theophylline in adult Chinese patients with asthma and chronic obstructive pulmonary disease.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Asian People; Asthma; Bronchodilator Agents; C | 2018 |
Nationwide use of theophylline among adults-A 20-year Danish drug utilisation study.
Topics: Aged; Aged, 80 and over; Asthma; Bronchodilator Agents; Denmark; Drug Administration Schedule; Drug | 2018 |
Review of the British Thoracic Society Winter Meeting 2018, 5-7 December 2018, London, UK.
Topics: Asthma; Bronchodilator Agents; Cystic Fibrosis; Drug Resistance, Microbial; Genetic Therapy; Humans; | 2019 |
The course of asthma in young adults: a population-based nine-year follow-up on asthma remission and control.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Age Factors; Anti-Asthmatic Agents; Anti-I | 2014 |
[Asthma and adrenalin-theophylline aerosol; emergency and ambulatory treatment].
Topics: Aerosols; Asthma; Epinephrine; Humans; Theophylline | 1950 |
Small airway dysfunction is associated with poorer asthma control.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Forced | 2014 |
Japanese Guideline for Adult Asthma 2014.
Topics: Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Antibodies, Monoclonal; Asthma; | 2014 |
Effects of provinol and its combinations with clinically used antiasthmatics on airway defense mechanisms in experimental allergic asthma.
Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; | 2015 |
Tiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life data.
Topics: Administration, Inhalation; Adult; Aged; Airway Obstruction; Anti-Asthmatic Agents; Asthma; Bronchod | 2016 |
Evaluation of asthma control by inhaled corticosteroids in general practice in Thailand.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; | 2015 |
Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease.
Topics: Adult; Asthma; Bronchodilator Agents; Female; Humans; Male; Pulmonary Disease, Chronic Obstructive; | 2015 |
The Use of X Rays in the Treatment of Bronchial Asthma: A Historical Assessment.
Topics: Anti-Bacterial Agents; Asthma; Histamine Antagonists; History, 20th Century; Humans; Theophylline; X | 2015 |
How multiple medication use evolves and the importance of therapeutic trials: the slippery slide.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Anxiety Disorders; Asthma; Broncho | 2008 |
[Bronchial asthma in children and adolescents].
Topics: Adolescent; Adrenal Cortex Hormones; Age Factors; Allergens; Anti-Asthmatic Agents; Asthma; Bronchod | 2008 |
[Nocturnal shortness of breath: in asthma look for reflux -- is it worthwhile?].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Asthma; Bronchodilator Agents; Gastroesophageal Reflux; Hum | 2008 |
Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients.
Topics: Acute Disease; Aging; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Child; Child, Prescho | 2009 |
Development and evaluation of pulsatile drug delivery system using novel polymer.
Topics: Asthma; Bronchodilator Agents; Capsules; Chemistry, Pharmaceutical; Colon; Delayed-Action Preparatio | 2009 |
Adherence with long-term asthma management in patients who experienced hospitalized asthma exacerbation.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; Aged; Aged, 80 and over; Asthma; Emergencie | 2009 |
[Pulmonary diseases in pregnancy. What drugs are permitted?].
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antitubercular Agents; | 2009 |
Drug therapy for asthma.
Topics: Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Asthma; Ephedrine; Humans; Theophylline | 2009 |
Novel chronotherapeutic rectal aminophylline delivery system for therapy of asthma.
Topics: Acrylic Resins; Administration, Rectal; Alginates; Aminophylline; Animals; Asthma; Bronchodilator Ag | 2009 |
Theophylline again? Reasons for believing.
Topics: Anti-Inflammatory Agents; Aspirin; Asthma; Bronchodilator Agents; Humans; Inflammation; Phosphoric D | 2009 |
Hospitalizations for asthma in an urban population: 1995-1999.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Age Factors; Asthma; Black or | 2009 |
Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; | 2010 |
Respiratory delivery of theophylline by size-targeted starch microspheres for treatment of asthma.
Topics: Administration, Inhalation; Asthma; Cross-Linking Reagents; Delayed-Action Preparations; Drug Carrie | 2009 |
Regression of giant bullous emphysema.
Topics: Administration, Inhalation; Albuterol; Asthma; Bronchodilator Agents; Drug Therapy, Combination; Hum | 2010 |
Aminophylline with a barbiturate as a rectal suppository in the treatment of asthma.
Topics: Aminophylline; Asthma; Barbital; Barbiturates; Humans; Suppositories; Theophylline | 1947 |
The treatment of asthma by inhalation of aerosol of aminophyllin.
Topics: Administration, Inhalation; Aerosols; Aminophylline; Asthma; Humans; Theophylline | 1947 |
Development of colon targeted multiparticulate pulsatile drug delivery system for treating nocturnal asthma.
Topics: Acrylic Resins; Animals; Asthma; Bronchodilator Agents; Colon; Delayed-Action Preparations; Drug Chr | 2010 |
Hyperlactic acidosis as metabolic side-effect of albuterol and theophylline in acute severe asthma.
Topics: Acidosis, Lactic; Administration, Inhalation; Adolescent; Albuterol; Anti-Asthmatic Agents; Anti-Inf | 2010 |
The indication and effectiveness of low-dose erythromycin therapy in pediatric patients with bronchial asthma.
Topics: Anti-Asthmatic Agents; Anti-Bacterial Agents; Asthma; Chemokine CCL11; Child; Child, Preschool; Dose | 2010 |
A new definition of pharmaceutical quality: assembly of a risk simulation platform to investigate the impact of manufacturing/product variability on clinical performance.
Topics: Absorption; Administration, Oral; Asthma; Bronchodilator Agents; Chemistry, Pharmaceutical; Commerce | 2010 |
Usefulness of the simultaneous determination of serum levels of theophylline and its metabolites in patients medicated with theophylline preparation.
Topics: Asthma; Bronchodilator Agents; Caffeine; Chromatography, High Pressure Liquid; Humans; Smoking; Theo | 2011 |
Dual cross-linked pulsatile beads for chronotherapy of asthma: development and evaluation.
Topics: Alginates; Animals; Asthma; Biocompatible Materials; Bronchodilator Agents; Chemistry, Pharmaceutica | 2010 |
A new pressure-controlled colon delivery capsule for chronotherapeutic treatment of nocturnal asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Biological Availability; Capsules; Chromatography, High Pres | 2011 |
Intratracheal sensitization/challenge-induced biphasic asthmatic response and airway hyperresponsiveness in guinea pigs.
Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Antigens; Asthma; Bronchial Hyperreactivity; Chro | 2010 |
Design and optimization of colon-targeted system of theophylline for chronotherapy of nocturnal asthma.
Topics: Animals; Asthma; Bronchodilator Agents; Cellulose; Chronotherapy; Colon; Delayed-Action Preparations | 2011 |
pH-enzyme di-dependent chronotherapeutic drug delivery system of theophylline for nocturnal asthma.
Topics: Animals; Asthma; Drug Chronotherapy; Drug Delivery Systems; Galactans; Hydrogen-Ion Concentration; M | 2011 |
Design and synthesis of some new theophylline derivatives with bronchodilator and antibacterial activities.
Topics: Aminophylline; Ampicillin; Animals; Anti-Bacterial Agents; Asthma; Bronchial Spasm; Bronchodilator A | 2011 |
In vitro and in vivo evaluation of multilayered pastilles for chronotherapeutic management of nocturnal asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Delayed-Action Preparations; Drug Carriers; Drug Chronothera | 2012 |
Demographic, physiologic and radiographic characteristics of COPD patients taking chronic systemic corticosteroids.
Topics: Administration, Oral; Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Female; Forced Expira | 2012 |
Association between asthma medications and suicidal ideation in adult asthmatics.
Topics: Adrenergic beta-2 Receptor Agonists; Adult; Anti-Asthmatic Agents; Asthma; Benzodiazepines; Bronchod | 2012 |
Spanish COPD Guidelines (GesEPOC): pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery.
Topics: Adrenal Cortex Hormones; alpha 1-Antitrypsin; Aminopyridines; Anti-Bacterial Agents; Asthma; Benzami | 2012 |
Influences of pyrexia and age on theophylline clearance in young children with asthma.
Topics: Age Factors; Asthma; Body Temperature; Bronchodilator Agents; Child, Preschool; Drug Dosage Calculat | 2012 |
Evaluation of in vivo behavior of controlled and pulsatile release pastilles using pharmacokinetic and γ-scintigraphic techniques.
Topics: Administration, Oral; Animals; Asthma; Biological Availability; Bronchodilator Agents; Chromatograph | 2012 |
Design and synthesis of new 8-anilide theophylline derivatives as bronchodilators and antibacterial agents.
Topics: Aminophylline; Ampicillin; Anilides; Animals; Anti-Bacterial Agents; Asthma; Bronchial Spasm; Bronch | 2012 |
The achilles heel in melatonin: asthma.
Topics: Acetylcholine; Animals; Asthma; Circadian Rhythm; Dose-Response Relationship, Drug; Injections, Intr | 2012 |
Theophylline blood levels in Sri Lankan asthmatics: comparison of two methods of assay.
Topics: Adult; Aged; Asthma; Bronchodilator Agents; Cross-Sectional Studies; Drug Monitoring; Enzyme Multipl | 2002 |
Lactic acidosis associated with the usual theophylline dose in a patient with asthma.
Topics: Acidosis, Lactic; Adult; Asthma; Bronchodilator Agents; Female; Humans; Hyperglycemia; Hypokalemia; | 2002 |
Conclusion without support - remarks on 'Efficacy and safely of doxyphyllin compared to Theophylline in chronic reversible asthma- a double-blind randomized placebo-controlled multicentre trial' by Goldstein MF, Chervinsky P (published in MedSciMonit, 200
Topics: Asthma; Bronchodilator Agents; Double-Blind Method; Humans; Multicenter Studies as Topic; Placebos; | 2002 |
[Theophylline in asthma and COPD. Saving on inhalational steroids].
Topics: Administration, Inhalation; Anti-Inflammatory Agents; Asthma; Delayed-Action Preparations; Dose-Resp | 2002 |
Acute generalized exanthematous pustulosis induced by ingestion of bamifylline.
Topics: Asthma; Bronchodilator Agents; Drug Eruptions; Exanthema; Female; Humans; Middle Aged; Skin Diseases | 2002 |
An evaluation of population D-optimal designs via pharmacokinetic simulations.
Topics: AIDS Vaccines; Algorithms; Asthma; Clinical Trials as Topic; Computer Simulation; Dose-Response Rela | 2003 |
Asthma control in the Asia-Pacific region: the Asthma Insights and Reality in Asia-Pacific Study.
Topics: Adrenal Cortex Hormones; Adult; Asia; Asthma; Bronchodilator Agents; Child; Child, Preschool; Data C | 2003 |
Inhaled steroid therapy and hospitalization for bronchial asthma: trend in Tokushima University Hospital.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Androstadienes; Anti- | 2003 |
Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma.
Topics: Albuterol; Animals; Antigens, CD34; Apoptosis; Asthma; Cell Division; Female; Humans; Male; Methacho | 2003 |
Theophylline attenuates the adhesion of eosinophils to endothelial cells.
Topics: Adult; Asthma; Bronchodilator Agents; Cell Adhesion; Cyclic AMP; Endothelium, Vascular; Eosinophils; | 2003 |
[Treatment of bronchial asthma in pregnancy].
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Female; Huma | 2003 |
Successful treatment of theophylline toxicity by upper gastrointestinal endoscopy.
Topics: Abdominal Pain; Adult; Asthma; Bronchodilator Agents; Delayed-Action Preparations; Endoscopy, Gastro | 2003 |
Effects of a nitro compound patch on neuropathy in Churg-Strauss syndrome.
Topics: Adrenergic beta-Agonists; Asthma; Churg-Strauss Syndrome; Cyclophosphamide; Drug Hypersensitivity; F | 2003 |
Prescribing for asthmatic children in primary care. Are we following guidelines?
Topics: Adolescent; Adrenergic beta-Agonists; Albuterol; Asthma; Bronchodilator Agents; Child; Child, Presch | 2003 |
Theophylline suppresses IL-5 and IL-13 production, and lymphocyte proliferation upon stimulation with house dust mite in asthmatic children.
Topics: Adolescent; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Child; Child, Preschool | 2003 |
Low dose theophylline in asthma: let us give a chance.
Topics: Asthma; Bronchodilator Agents; Humans; Theophylline | 2003 |
[Effect of theophylline-ethylenediamine on vital capacity in asthma following ACTH therapy].
Topics: Adrenocorticotropic Hormone; Aminophylline; Asthma; Ethylenediamines; Humans; Theophylline; Tidal Vo | 1952 |
[New soluble derivative of theophylline combined with phenobarbital].
Topics: Asthma; Barbiturates; Dyspnea; Dyspnea, Paroxysmal; Phenobarbital; Theophylline | 1952 |
[Theophylline, its derivatives and its associations in the treatment of asthma].
Topics: Asthma; Humans; Theophylline | 1953 |
[Statistical statements on theophylline-ethylenediamine treatment of bronchial asthma].
Topics: Aminophylline; Asthma; Humans; Theophylline | 1953 |
[The resistance of the bronchial system in asthma and other bronchial diseases and its modification by dihydroxytheophylline test].
Topics: Asthma; Bronchi; Bronchial Diseases; Disease; Humans; Theophylline | 1953 |
[Experimental studies on therapy of bronchial asthma].
Topics: Asthma; Ephedrine; Humans; Papaverine; Theophylline | 1953 |
[Effect of various broncholytics in bronchial asthma].
Topics: Asthma; Norepinephrine; Theophylline | 1953 |
[Experience with neburil in inhalation therapy of respiratory diseases, especially asthma and bronchiectatic bronchitis].
Topics: Aerosols; Asthma; Bronchiectasis; Bronchitis; Humans; Propane; Respiratory Therapy; Theophylline | 1954 |
Orthoxine-theophylline for the relief of bronchial asthma.
Topics: Asthma; Humans; Methamphetamine; Sympathomimetics; Theophylline | 1954 |
The effective use of choline theophyllinate in the treatment of bronchial asthma and premenstrual molimina.
Topics: Asthma; Choline; Humans; Menstruation; Theophylline | 1954 |
[The value of theophylline derivatives in the treatment of bronchial asthma, their mode of application and dosage].
Topics: Asthma; Humans; Theophylline | 1954 |
[Therapy of asthmatoid states].
Topics: Asthma; Ephedrine; Histamine H1 Antagonists; Humans; Theophylline | 1954 |
New Aspects of Asthma Therapy.
Topics: Asthma; Theophylline | 1954 |
[Clinical examination of a new water-soluble theophylline body].
Topics: Asthma; Blood Pressure; Heart; Humans; Theophylline | 1954 |
[Peripherin in the treatment of bronchial asthma and emphysema].
Topics: Asthma; Cytoskeletal Proteins; Emphysema; Intermediate Filaments; Peripherins; Pulmonary Emphysema; | 1955 |
The evaluation of bronchodilator drugs in the treatment of asthma.
Topics: Asthma; Bronchodilator Agents; Epinephrine; Humans; Theophylline | 1955 |
[Bronchial asthma and its treatment].
Topics: Asthma; Cardiovascular Agents; Humans; Lobelia; Muscle Relaxants, Central; Theophylline | 1955 |
[Therapeutic possibilities in bronchial asthma].
Topics: Analgesics; Asthma; Theophylline | 1955 |
[Treatment of bronchial asthma with asthmone].
Topics: Asthma; Barbiturates; Calcium; Calcium, Dietary; Codeine; Ephedrine; Humans; Theophylline | 1955 |
Calcium theophyllinate in the treatment of bronchial asthma.
Topics: Asthma; Calcium, Dietary; Theophylline | 1955 |
Severe toxic effects from aminophylline and theophylline suppositories in children.
Topics: Aminophylline; Asthma; Child; Humans; Infant; Respiratory System; Respiratory Tract Diseases; Suppos | 1956 |
[Some cases treated with inhalation of neburil].
Topics: Asthma; Bronchitis; Propane; Theophylline | 1956 |
[Treatment of asthmatic dyspnea with neo-efrodal].
Topics: Asthma; Dyspnea; Theophylline | 1956 |
[Clinicotherapeutic research on a new synthetic theophylline derivative].
Topics: Asthma; Cardiovascular Diseases; Humans; Research; Theophylline | 1956 |
[Clinicotherapeutic research on a new synthetic theophylline derivative].
Topics: Asthma; Cardiovascular Diseases; Humans; Research; Theophylline | 1956 |
[Clinicotherapeutic research on a new synthetic theophylline derivative].
Topics: Asthma; Cardiovascular Diseases; Humans; Research; Theophylline | 1956 |
[Clinicotherapeutic research on a new synthetic theophylline derivative].
Topics: Asthma; Cardiovascular Diseases; Humans; Research; Theophylline | 1956 |
[Treatment of asthmoid diseases].
Topics: Analgesics; Asthma; Ephedrine; Humans; Theophylline; Thiazoles | 1956 |
[Treatment of asthmoid diseases].
Topics: Analgesics; Asthma; Ephedrine; Humans; Theophylline; Thiazoles | 1956 |
[Treatment of asthmoid diseases].
Topics: Analgesics; Asthma; Ephedrine; Humans; Theophylline; Thiazoles | 1956 |
[Treatment of asthmoid diseases].
Topics: Analgesics; Asthma; Ephedrine; Humans; Theophylline; Thiazoles | 1956 |
[Influenceability of lung ventilation capacity in bronchospastic conditions].
Topics: Asthma; Atropine Derivatives; Bronchitis; Humans; Lung Volume Measurements; Papaverine; Phenobarbita | 1957 |
[Influenceability of lung ventilation capacity in bronchospastic conditions].
Topics: Asthma; Atropine Derivatives; Bronchitis; Humans; Lung Volume Measurements; Papaverine; Phenobarbita | 1957 |
[Influenceability of lung ventilation capacity in bronchospastic conditions].
Topics: Asthma; Atropine Derivatives; Bronchitis; Humans; Lung Volume Measurements; Papaverine; Phenobarbita | 1957 |
[Influenceability of lung ventilation capacity in bronchospastic conditions].
Topics: Asthma; Atropine Derivatives; Bronchitis; Humans; Lung Volume Measurements; Papaverine; Phenobarbita | 1957 |
Clinical experience with an oral, rapidly-acting, theophylline preparation.
Topics: Asthma; Humans; Theophylline | 1957 |
[Rectal use of the broncholytic kellidrin].
Topics: Administration, Rectal; Asthma; Bronchitis; Diphenhydramine; Emphysema; Ephedrine; Humans; Khellin; | 1957 |
The treatment of the acute asthmatic attack with an oral alcohol-water solution of theophylline (elixophyllin).
Topics: Acute Disease; Airway Obstruction; Alcohols; Asthma; Humans; Theophylline; Water | 1957 |
An objective comparison of two recent neutral theophylline compounds with aminophylline.
Topics: Aminophylline; Asthma; Bronchitis; Ethylenediamines; Humans; Hydrogen-Ion Concentration; Theophyllin | 1957 |
[Treatment of asthma with efrodal B; review of three years of experience].
Topics: Asthma; Atropine; Azoles; Humans; Magnesium; Phenobarbital; Sympathomimetics; Theophylline | 1957 |
[Results of a test of a pure theophylline in a pulmotest and a clinical trial in bronchial asthma].
Topics: Aminopyrine; Asthma; Humans; Theophylline | 1957 |
[Research on rectal administration of water-soluble theophylline derivatives in the treatment of bronchial asthma].
Topics: Administration, Rectal; Asthma; Research; Theophylline; Water | 1957 |
[Gambaran: antiasthmatic].
Topics: Aminopyrine; Anti-Asthmatic Agents; Asthma; Cardiovascular Agents; Diphenhydramine; Muscle Relaxants | 1957 |
[Objectively determined effect of an antiasthmatic].
Topics: Adonis; Alkaloids; Anti-Asthmatic Agents; Asthma; Cardiac Glycosides; Datura stramonium; Ephedrine; | 1958 |
[Effect of theophylline ethylenediethylamine on oxygen consumption during effort].
Topics: Asthma; Humans; Oxygen Consumption; Theophylline | 1957 |
A new xanthine derivative: theophylline with diethylenediamine; a clinical study.
Topics: Asthma; Biomedical Research; Piperazines; Theophylline; Xanthine; Xanthines | 1958 |
[New clinical experiences concerning bronchial asthma].
Topics: Asthma; Hormones; Humans; Pituitary Gland; Pituitary Gland, Posterior; Procaine; Theophylline | 1958 |
[Symptomatic asthma therapy].
Topics: Asthma; Ephedrine; Humans; Phenobarbital; Theophylline | 1958 |
Choledyl, choline theophyllinate (BAN).
Topics: Asthma; Dyspnea; Dyspnea, Paroxysmal; Humans; Theophylline | 1959 |
[Therapeutic theophylline poisoning of a young child and infant].
Topics: Asthma; Child; Diuretics; Humans; Infant; Theophylline | 1959 |
[Trial therapy of asthma in children using a theophylline derivative administered subcutaneously].
Topics: Asthma; Child; Humans; Infant; Theophylline | 1959 |
Spirometric evaluation of a water-alcohol-soluble theophylline (elixophyllin) in acetylcholine-induced asthma.
Topics: Acetylcholine; Asthma; Ethanol; Spirometry; Theophylline; Water | 1959 |
Drug absorption and elimination as guide to rational therapy in bronchial asthma.
Topics: Asthma; Biological Transport; Humans; Theophylline | 1959 |
Hydroxyzine as a component of anti-asthmatic treatment.
Topics: Anti-Asthmatic Agents; Asthma; Ephedrine; Humans; Hydroxyzine; Theophylline | 1961 |
Hydroalcoholic theophylline preparation (Elixophyllin) in the management of bronchial asthma.
Topics: Asthma; Disease Management; Theophylline | 1960 |
Clinical experience with Elixophyllin in dyspnea.
Topics: Asthma; Dyspnea; Dyspnea, Paroxysmal; Humans; Pulmonary Emphysema; Theophylline | 1960 |
[Treatment of insomnia in asthmatics with hypnasmine].
Topics: Asthma; Barbiturates; Caffeine; Humans; Sleep Initiation and Maintenance Disorders; Theophylline | 1960 |
[Comparative studies on the action of aerosol inhalants on broncholysis and oxygen supply in obstructive lung diseases].
Topics: Aerosols; Asthma; Ephedrine; Humans; Lung Diseases; Lung Diseases, Obstructive; Oxygen; Respiratory | 1961 |
[Clinical considerations on the use of a new pharmacological combination with low prednisone content in therapy of bronchial asthma].
Topics: Asthma; Ephedrine; Prednisone; Theophylline | 1959 |
Choline theophyllinate in children with asthma: a controlled trial.
Topics: Asthma; Child; Choline; Humans; Theophylline | 1960 |
[Observations on the therapeutic effect of a new bronchodilator].
Topics: Asthma; Bronchitis; Bronchodilator Agents; Choline; Humans; Pulmonary Emphysema; Quinolines; Theophy | 1962 |
[Combination of franol and phenerol in asthma].
Topics: Anti-Allergic Agents; Asthma; Drug Combinations; Ephedrine; Ethylenediamines; Histamine H1 Antagonis | 1962 |
[The combination of Franol and Fenerol in asthma].
Topics: Anti-Allergic Agents; Asthma; Drug Combinations; Ephedrine; Ethylenediamines; Histamine H1 Antagonis | 1962 |
[Therapeutic value in respiratory pathology, of tablets combining 1.5 mg of prednisolone and 120 mg of theophylline with 10 mg of phenobarbital].
Topics: Asthma; Humans; Phenobarbital; Prednisolone; Tablets; Theophylline | 1962 |
Symptomatic treatment of infectious asthma in children.
Topics: Asthma; Communicable Diseases; Iodides; Phenobarbital; Sympathomimetics; Theophylline | 1962 |
Clinical evaluation of a theophylline solution (Elixophyllin) in children with bronchial asthma.
Topics: Asthma; Child; Infant; Pharmaceutical Solutions; Solutions; Theophylline | 1962 |
[The development of a new injectable asthma drug by clinical and experimental testing of various types of broncholytic agents].
Topics: Antipsychotic Agents; Asthma; Bronchodilator Agents; Humans; Khellin; Phenothiazines; Theophylline | 1962 |
[Acetylcholine bronchospasm as a clinical method for the quantitative assay of broncholytics].
Topics: Acetylcholine; Asthma; Bronchial Spasm; Diphenhydramine; Khellin; Theophylline | 1961 |
[Bronchial asthma].
Topics: Asthma; Humans; Theophylline | 1963 |
Management of asthma--bronchodilators.
Topics: Asthma; Atropine; Bronchodilator Agents; Disease Management; Humans; Steroids; Sympathomimetics; The | 1962 |
[Experiences with the prolonged-action anti-asthmatic drug: Asmapax (Nicholas)].
Topics: Anti-Asthmatic Agents; Asthma; Bromides; Ephedrine; Humans; Theophylline | 1963 |
Librium-theophylline-ephedrine compound in bronchial asthma. A double blind study in 100 patients.
Topics: Asthma; Chlordiazepoxide; Double-Blind Method; Ephedrine; Humans; Theophylline | 1963 |
[Experiences with Makara, a successful antiasthmatic power].
Topics: Anti-Asthmatic Agents; Antipyrine; Asthma; Ephedrine; Papaverine; Phenacetin; Theophylline | 1962 |
Resprium (Librium-theophylline-ephedrine compound) in the treatment of bronchial asthma and respiratory allergy.
Topics: Asthma; Chlordiazepoxide; Ephedrine; Humans; Respiratory Hypersensitivity; Theophylline; Tranquilizi | 1962 |
[Theomyl, a new synthetic asthma preparation].
Topics: Albuterol; Asthma; Caffeine; Epinephrine; Ipratropium; Theophylline | 1962 |
Bronchial asthma--views on therapy.
Topics: Adrenocorticotropic Hormone; Asthma; Cortisone; Expectorants; Humans; Theophylline | 1963 |
Theophylline glyceryl guaiacolate (Quibron) in bronchial asthma.
Topics: Asthma; Guaifenesin; Theophylline | 1962 |
[Clinico-experimental study with a new combination drug in the treatment of bronchial asthma].
Topics: Asthma; Barbiturates; Dexamethasone; Ephedrine; Meprobamate; Methylprednisolone; Theophylline | 1962 |
DILAMIN IN ALLERGIC CONDITIONS; A STUDY OF 200 CASES.
Topics: Adolescent; Angioedema; Asthma; Child; Eczema; Histamine H1 Antagonists; Humans; Hypersensitivity; R | 1963 |
[SPIROGRAPHIC STUDIES ON ASTHMATIC DYSPNEA].
Topics: Asthma; Atropine; Dyspnea; Humans; Papaverine; Phenobarbital; Spirometry; Theophylline | 1963 |
[TREATMENT OF BRONCHIAL ASTHMA IN CHILDREN].
Topics: Ascorbic Acid; Aspirin; Asthma; Cell- and Tissue-Based Therapy; Child; Ephedrine; Immunotherapy, Act | 1963 |
ADDITION OF GLYCERYL GUAIACOLATE TO OXTRIPHYLLINE IN CHRONIC ASTHMA: A DOUBLE BLIND STUDY.
Topics: Asthma; Choline; Double-Blind Method; Guaifenesin; Humans; Theophylline | 1963 |
EVALUATION OF A CHLORDIAZEPOXIDE, THEOPHYLLINE, EPHEDRINE COMBINATION IN THE TREATMENT OF BRONCHIAL ASTHMA.
Topics: Asthma; Chlordiazepoxide; Ephedrine; Humans; Theophylline | 1963 |
A DOUBLE BLIND CLINICAL EVALUATION OF GLYCERYL GUAIACOLATE.
Topics: Asthma; Bronchiectasis; Bronchitis; Choline; Cough; Double-Blind Method; Guaifenesin; Pulmonary Emph | 1963 |
THEOPHYLLINE-GLYCERYL GUAIACOLATE CAPSULES (QUIBRON). CLINICAL RESULTS IN BRONCHIAL ASTHMA.
Topics: Asthma; Capsules; Guaiacol; Guaifenesin; Humans; Theophylline; Toxicology | 1963 |
THE PLACE OF PHYSICAL EXERCISE AND BRONCHODILATOR DRUGS IN THE ASSESSMENT OF THE ASTHMATIC CHILD.
Topics: Asthma; Atropine; Bronchodilator Agents; Child; Ephedrine; Epinephrine; Exercise; Humans; Isoprotere | 1963 |
[TREATMENT OF ASTHMA IN THE ADULT].
Topics: Adrenal Cortex Hormones; Adult; Asthma; Humans; Theophylline | 1963 |
[CURRENT THERAPEUTIC METHODS IN THE THOROUGH TREATMENT OF ASTHMA].
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Allergic Agents; Asthma; Bloo | 1963 |
CLINICAL EVALUATION OF ELIXOPHYLLIN WITH CORRELATION OF PULMONARY FUNCTION STUDIES AND THEOPHYLLINE SERUM LEVELS IN ACUTE AND CHRONIC ASTHMATIC PATIENTS.
Topics: Asthma; Blood Chemical Analysis; Epinephrine; Humans; Lung; Pharmacology; Respiratory Function Tests | 1964 |
CLINICAL EVALUATION OF A BRONCHODILATOR DRUG COMBINATION IN CHILDREN WITH CHRONIC BRONCHIAL ASTHMA.
Topics: Adolescent; Aerosols; Anti-Allergic Agents; Asthma; Bronchodilator Agents; Child; Drug Combinations; | 1964 |
TREATMENT OF BRONCHIAL AND PULMONARY PARENCHYMAL DISORDERS.
Topics: Asthma; Bronchitis; Geriatrics; Guaifenesin; Humans; Lung Diseases; Pulmonary Emphysema; Pulmonary F | 1964 |
OXTRIPHYLLINE-GLYCERYL GUAIACOLATE ELIXIR AS EFFECTIVE THERAPY FOR CHRONIC BRONCHITIS AND ASTHMA.
Topics: Adolescent; Asthma; Bronchitis; Bronchitis, Chronic; Child; Choline; Geriatrics; Guaifenesin; Humans | 1964 |
[CLINICAL STUDY OF A EUPNEIC AGENT: AMPLIPHYLLINE].
Topics: Asthma; Bronchiectasis; Bronchitis; Bronchodilator Agents; Dyspnea; Dyspnea, Paroxysmal; Humans; Lun | 1964 |
SYMPTOMATIC TREATMENT OF BRONCHIAL ASTHMA WITH A NEW ANTIASTHMATIC DRUG COMBINATION.
Topics: Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Histamine H1 Antagonists; Humans; Sympathomimet | 1964 |
ADVANCES IN PHYSIOLOGIC TECHNICS FOR REHABILITATION OF ASTHMATIC PATIENT.
Topics: Acidosis; Adrenal Cortex Hormones; Aerosols; Anti-Bacterial Agents; Asthma; Breathing Exercises; Die | 1964 |
THE DIAGNOSIS AND TREATMENT OF ASTHMA IN THE ELDERLY.
Topics: Aerosols; Aged; Asthma; Betamethasone; Bronchiectasis; Bronchitis; Dexamethasone; Dyspnea; Dyspnea, | 1964 |
THE MANAGEMENT OF ASTHMATIC PATIENTS IN A CASUALTY DEPARTMENT.
Topics: Adrenal Cortex Hormones; Aminophylline; Amobarbital; Anti-Bacterial Agents; Antibiotics, Antitubercu | 1964 |
[CLINICAL AND THERAPEUTIC ASPECTS OF BRONCHIAL ASTHMA IN GERMANY].
Topics: Adrenal Cortex Hormones; Asthma; Desensitization, Immunologic; Diagnosis; Ephedrine; Germany; Humans | 1964 |
[CLINICAL AND THERAPEUTIC ASPECTS OF BRONCHIAL ASTHMA IN FRANCE].
Topics: Adrenal Cortex Hormones; Asthma; Diagnosis; France; Humans; Skin Tests; Theophylline | 1964 |
[DIAGNOSIS AND TREATMENT OF ASTHMA-LIKE SYNDROMES].
Topics: Adrenal Cortex Hormones; Aminopyrine; Asthma; Breathing Exercises; Bronchial Diseases; Chymotrypsin; | 1964 |
DRUGS IN THE TREATMENT OF ASTHMA.
Topics: Adrenocorticotropic Hormone; Aerosols; Aminophylline; Anti-Bacterial Agents; Asthma; Child; Ephedrin | 1964 |
BRONCHIAL ASTHMA.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aminophylline; Anti-Bacterial Agents; Antibiot | 1964 |
[ON THE TREATMENT OF PATIENTS SUFFERING FROM CHRONIC BRONCHITIS].
Topics: Anti-Bacterial Agents; Asthma; Bronchitis; Bronchitis, Chronic; Bronchoscopy; Clinical Laboratory Te | 1964 |
[ON ISOLATED ALLERGIC MYOCARDITIS].
Topics: Asthma; Bronchitis; Caffeine; Cardiac Complexes, Premature; Drug Therapy; Electrocardiography; Epine | 1964 |
[CLINICAL AND PATHOMORPHOLOGICAL FINDINGS IN CHRONIC ADDICTION TO ANTIASTHMATIC DRUGS].
Topics: Alkaloids; Anti-Asthmatic Agents; Asthma; Barbiturates; Brain; Ephedrine; Epinephrine; Lipids; Patho | 1964 |
ANAPHYLACTIC MICROSHOCK IN THE SCREENING OF SOME THEOPHYLLINES AND BENZYLPHENOXYAMINOALKANES FOR ANTIASTHMATIC ACTIVITY.
Topics: Aminophylline; Anaphylaxis; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Chemistry, | 1963 |
[MEDICATIONS AND TREATMENT OF ASTHMA. I. SYMPTOMATIC MEDICATIONS].
Topics: Adrenal Cortex Hormones; Anti-Allergic Agents; Asthma; Bronchodilator Agents; Drug Therapy; Histamin | 1964 |
[RESULTS OF CLINICAL EXPERIMENTATION WITH AC 3810 (TRENTADIL)].
Topics: Adolescent; Asthma; Biliary Tract; Biomedical Research; Colic; Dysmenorrhea; Female; Geriatrics; Hum | 1964 |
CLINICAL EVALUATION OF BRONDECON TABLETS IN CHRONIC BRONCHIAL ASTHMA.
Topics: Asthma; Bronchitis; Bronchodilator Agents; Choline; Geriatrics; Guaiacol; Humans; Pulmonary Emphysem | 1964 |
GUAIACOL GLYCERYL ETHER THEOPHYLLINATE. ITS VALUE FOR RELIEF OF BRONCHIAL ASTHMA AND RELATED BRONCHOSPASTIC CONDITIONS.
Topics: Aminophylline; Asthma; Blood; Bronchial Spasm; Drug Therapy; Guaifenesin; Humans; Theophylline | 1964 |
CLINICAL TRIAL OF A NEW THEOPHYLLINE PREPARATION.
Topics: Adolescent; Asthma; Biomedical Research; Bronchial Neoplasms; Bronchitis; Child; Diarrhea; Drug Ther | 1964 |
OXTRIPHYLLINE GLYCERYL GUAIACOLATE ELIXIR IN PEDIATRIC ASTHMA: WITH A THEOPHYLLINE REVIEW.
Topics: Adolescent; Asthma; Biomedical Research; Child; Choline; Drug Therapy; Expectorants; Glycerol; Guaia | 1965 |
[STUDY OF AN ANTIASTHMATIC COMBINATION OF ACTIVE SUBSTANCES (ASMAC) IN A PULMONARY TEST AND THE INDICATIONS FOR ITS THERAPEUTIC USE].
Topics: Anti-Asthmatic Agents; Asthma; Barbiturates; Drug Therapy; Ephedrine; Research; Theophylline | 1964 |
[THE ACTION OF AMBREDINE IN THE TREATMENT OF ASTHMATIC SYNDROMES].
Topics: Aminopyrine; Asthma; Bronchodilator Agents; Cardiovascular Agents; Drug Therapy; Humans; Methenamine | 1964 |
[Parenteral asthma therapy, a dosage problem].
Topics: Asthma; Humans; Theophylline; Thiazoles | 1955 |
[Theophylline and venous pressure].
Topics: Asthma; Blood Pressure; Blood Pressure Determination; Diuretics; Heart Diseases; Theophylline; Venou | 1955 |
[Broncholysis by means of water-soluble theophylline derivatives].
Topics: Asthma; Theophylline; Water | 1955 |
Non-steroid management of bronchial asthma.
Topics: Asthma; Disease Management; Theophylline | 1959 |
Acute and chronic asthma. Treatment with theophylline in hydro-alcoholic solution: clinical evaluation and pulmonary function studies.
Topics: Asthma; Humans; Pharmaceutical Solutions; Respiratory Physiological Phenomena; Solutions; Theophylli | 1959 |
[The behavior of pulmonary ventilation in asthmatic bronchitis under the influence of theophylline-ethylenediamine].
Topics: Aminophylline; Asthma; Bronchitis; Ethylenediamines; Humans; Pulmonary Ventilation; Theophylline | 1960 |
Oral theophylline compounds in chronic asthma: a blind clinical trial.
Topics: Asthma; Blindness; Humans; Theophylline; Visually Impaired Persons | 1959 |
[Clinical evaluation of a new bronchospasmolytic agent called "Quibran"].
Topics: Asthma; Cardiovascular Agents; Muscle Relaxants, Central; Theophylline | 1962 |
The use of Marax inthe treatment of bronchial asthma.
Topics: Aluminum Hydroxide; Asthma; Ephedrine; Hydroxyzine; Magnesium Hydroxide; Theophylline | 1962 |
Use of a new elixir for prophylaxis in pediatric bronchial asthma.
Topics: Anti-Allergic Agents; Asthma; Cardiovascular Agents; Child; Ephedrine; Histamine H1 Antagonists; Hum | 1962 |
[Clinicotherapeutic experiences with Gambaran in bronchial asthma].
Topics: Aminopyrine; Asthma; Ephedrine; Theophylline | 1962 |
Theophylline-glyceryl guaiacolate elixir (Quibron) clinical and blood level studies in bronchial asthma in children.
Topics: Asthma; Cardiovascular Agents; Guaifenesin; Muscle Relaxants, Central; Research; Theophylline | 1962 |
Clinical evaluation of Bronkotabs: a new anti-asthmatic drug combination.
Topics: Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Histamine H1 Antagonists; Phenobarbital; Theoph | 1961 |
Sustained-action medication in perennial bronchial asthma.
Topics: Asthma; Ephedrine; Phenobarbital; Theophylline | 1962 |
[Clinical trial of a new antiasthmatic preparation].
Topics: Amino Alcohols; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Histamine H1 Antagonists; Theop | 1962 |
[Therapeutic results obtained with Enfisin].
Topics: Asthma; Choline; Pulmonary Emphysema; Quinolines; Theophylline; Tuberculosis; Tuberculosis, Pulmonar | 1962 |
Clinical evaluation of Quibron TM in asthma.
Topics: Asthma; Cardiovascular Agents; Muscle Relaxants, Central; Theophylline | 1961 |
A brief review of drug therapy in bronchial asthma.
Topics: Asthma; Ephedrine; Humans; Phenobarbital; Theophylline | 1962 |
[Consensus recommendations on drug treatment of bronchial asthma in children and adolescents. 1. Addendum (2003). Austrian Society for Pediatrics and Adolescent Medicine and Austrian Society for Lung Diseases and Tuberculosis].
Topics: Adolescent; Adolescent Medicine; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Age Facto | 2003 |
Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies.
Topics: Adult; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Birth Weight; Case-Control Studies; | 2003 |
Trends in emergency department asthma care in metropolitan Chicago: results from the Chicago Asthma Surveillance Initiative.
Topics: Asthma; Blood Gas Analysis; Bronchodilator Agents; Chicago; Cross-Sectional Studies; Data Collection | 2003 |
[Evaluation of the efficacy of inhaled glucocorticosteroids in mild bronchial asthma].
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Budesonide; Drug | 2003 |
[Theophylline and aminophylline].
Topics: Aminophylline; Asthma; Coronary Vessels; Humans; Theophylline | 1951 |
[Clinical experience in the treatment of asthmatic syndromes with dimethylbenzylpyridilethylenediamine associated with theophylline, ephedrine, and phenylethylmalonylurea].
Topics: Asthma; Ephedrine; Humans; Phenobarbital; Syndrome; Theophylline | 1952 |
What role for theophylline in asthma?
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Dose-Response Rela | 2004 |
Theophylline impairs memory/learning in developing mice.
Topics: Age Factors; Animals; Asthma; Brain; Bronchodilator Agents; Dose-Response Relationship, Drug; Hyperk | 2004 |
[Insanovin aerosol therapy in the treatment of bronchial asthma].
Topics: Adult; Aerosols; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchod | 2004 |
Unexpected fatality in a child from accidental consumption of antiasthmatic preparation containing ephedrine, theophylline and phenobarbital.
Topics: Anti-Asthmatic Agents; Asthma; Barbital; Biological Phenomena; Ephedrine; Phenobarbital; Physiologic | 1950 |
TREATMENT OF BRONCHOSPASTIC STATES IN CHILDREN WITH A THEOPHYLLINE-NOSCAPINE FORMULATION.
Topics: Asthma; Bronchitis; Chemistry, Pharmaceutical; Child; Delayed-Action Preparations; Humans; Noscapine | 1964 |
EVALUATION OF A NEW HYDROALCOHOLIC BRONCHODILATOR-EXPECTORANT IN ASTHMA.
Topics: Asthma; Bronchodilator Agents; Child; Choline; Expectorants; Geriatrics; Guaiacol; Respiratory Funct | 1964 |
A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD.
Topics: Aged; Aged, 80 and over; Asthma; Bronchodilator Agents; Delayed-Action Preparations; Female; Humans; | 2004 |
[Prevalence of gastroesophageal reflux disease in patients with bronchial asthma].
Topics: Adult; Asthma; Body Mass Index; Bronchodilator Agents; Female; Gastroesophageal Reflux; Glucocortico | 2004 |
[The current managements and controversies of the clinical practice for patients with asthma. A questionnaire survey of asthma management for doctors professing internal medicine in Saitama prefecture].
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Data Collecti | 2004 |
Effects of piclamilast, a selective phosphodiesterase-4 inhibitor, on oxidative burst of sputum cells from mild asthmatics and stable COPD patients.
Topics: Adult; Asthma; Benzamides; Female; Humans; Male; Middle Aged; Phosphodiesterase Inhibitors; Predniso | 2004 |
Effect of pet removal on pet allergic asthma.
Topics: Adult; Animals; Animals, Domestic; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Chrom | 2005 |
[New trend in asthma therapy. Already early administration of inhaled corticoids--but low dosage when possible for long-term treatment].
Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; | 2005 |
[Gastroesophageal reflux disease and respiratory apparatus pathology: the evidence of interrelation and unsolved problems].
Topics: Adult; Aged; Asthma; Bronchi; Bronchodilator Agents; Female; Gastroesophageal Reflux; Humans; Male; | 2005 |
Pharmacotherapy--add-on therapies.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Child; Child, Pr | 2005 |
[Poor compliance: what are the sequelae for the asthmatic patient?].
Topics: Acute Disease; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic | 2005 |
Community pharmacy-based pharmaceutical care for asthma patients.
Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asth | 2005 |
[Treatment compliance in asthma: a Tunisian transversal study].
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adult; Androstadienes; Anti-Asthmatic Agents; A | 2005 |
Regulation of NGF and BDNF by dexamethasone and theophylline in human peripheral eosinophils in allergics and non-allergics.
Topics: Anti-Inflammatory Agents; Asthma; Brain-Derived Neurotrophic Factor; Bronchodilator Agents; Cells, C | 2005 |
Underrecognition of the severity of asthma and undertreatment of asthma in a rural area of Japan.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Ant | 2005 |
[Perioperative evaluation of a kit for simplified measurement of blood theophylline concentration (Accumeter Theophylline)].
Topics: Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Child; Child, Preschool; Evaluation Studies | 2005 |
Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Bronchodilator Agents; Caffeine; Cytochrome P-450 CYP1A2; De | 2006 |
Drugs for asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Animals; Anti-Asthmatic Agents; Asthma; Chromones | 2006 |
[Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma].
Topics: Adolescent; Adult; Asthma; Eosinophils; Female; Humans; Male; Patch-Clamp Techniques; Potassium Chan | 2005 |
Theophylline metabolism in acute asthma with MxA-indicated viral infection.
Topics: Acute Disease; Asthma; Biomarkers; Child; Child, Preschool; Female; Flow Cytometry; GTP-Binding Prot | 2006 |
Phosphodiesterase type 4 inhibitors for asthma: a real breakthrough or just expensive theophylline?
Topics: Aminopyridines; Asthma; Benzamides; Cyclopropanes; Humans; Phosphodiesterase Inhibitors; Randomized | 2006 |
Telithromycin in acute exacerbations of asthma.
Topics: Anti-Bacterial Agents; Asthma; Drug Interactions; Drug Resistance, Bacterial; Humans; Ketolides; Mac | 2006 |
[Drug therapy of asthma. Results of the 1998 German National Health Interview and Examination Survey].
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Age Factors; Aged; Ambulatory Care; Anti-Asthmatic Agen | 2006 |
Time and pH dependent colon specific, pulsatile delivery of theophylline for nocturnal asthma.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Chemistry, Pharmaceutical; Colon; Cross-Linking Reagents; De | 2007 |
[Clinical review on patients who developed seizures during theophylline administration: relationships with seizure-predisposing factors].
Topics: Administration, Oral; Asthma; Bronchodilator Agents; Child; Child, Preschool; Humans; Injections, In | 2006 |
A prospective survey on safety of sustained-release theophylline in treatment of asthma and COPD.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Anti-Asthmatic Agents; Asthma; Bronchiti | 2006 |
Carbamazepine in asthma: first do no harm!
Topics: Administration, Oral; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Carbamazepine; Drug Syne | 2007 |
Montelukast and theophylline: no use or some use in persistent asthma?
Topics: Acetates; Anti-Asthmatic Agents; Asthma; Cyclopropanes; Humans; Quinolines; Randomized Controlled Tr | 2007 |
[A case of theophylline induced hypercalcemia].
Topics: Asthma; Bronchodilator Agents; Female; Hashimoto Disease; Humans; Hypercalcemia; Hyperthyroidism; Mi | 2007 |
[A clinical review of patients with convulsions during theophylline administration II: points to consider in administration and prognosis as determined in patients with theophyline toxicosis].
Topics: Asthma; Bronchodilator Agents; Child; Child, Preschool; Female; Humans; Infant; Male; Prognosis; Sei | 2007 |
Long-term asthma therapy: adapt steroid therapy to severity.
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Asthma; Beclomethasone; | 2007 |
[Management of acute asthma attack at home and at the hospital emergency department].
Topics: Acute Disease; Administration, Inhalation; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; | 2007 |
[The influence of a new combination preparation on distribution disorders as well as on the alveolar oxygen and carbonic acid partial pressure].
Topics: Adult; Asthma; Carbon Dioxide; Ephedrine; Humans; Male; Middle Aged; Oxygen; Partial Pressure; Pheno | 1966 |
[On the therapy of bronchial asthma in children].
Topics: Adolescent; Asthma; Bronchodilator Agents; Child; Child, Preschool; Drug Hypersensitivity; Epinephri | 1967 |
Effect of an anti-asthmatic compound on blood pressure of hypertensive asthmatic patients.
Topics: Adult; Aged; Asthma; Blood Pressure; Female; Guaifenesin; Humans; Hypertension; Male; Middle Aged; P | 1967 |
[Present possibilities in the treatment of asthma].
Topics: Adrenal Cortex Hormones; Asthma; Dyspnea, Paroxysmal; Humans; Sympathomimetics; Theophylline | 1967 |
Xanthines: central nervous system reactions in allergic individuals. Six years' experience with a theophylline-noscapine preparation.
Topics: Asthma; Blood Pressure; Bronchial Spasm; Central Nervous System; Cerebrovascular Circulation; Delaye | 1967 |
A combined drug for asthmatic symptoms.
Topics: Adolescent; Adult; Aged; Asthma; Child; Chronic Disease; Ephedrine; Female; Humans; Hydroxyzine; Hyp | 1967 |
The drug treatment of asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Aged; Asthma; Bronchodilato | 1984 |
Thirty-sixth Annual Meeting of the American Academy of Allergy, Atlanta, Georgia, February 16-20, 1980. Abstracts of papers.
Topics: Allergy and Immunology; Asthma; Congresses as Topic; Humans; Immunotherapy; Societies, Medical; Theo | 1980 |
A rational approach to asthma therapy.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Airway Resistance; Antigens; Asthma; Humans; Immu | 1980 |
Exercise-induced asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Asthma, Exercise-Induced; Body Temperature Regulation; | 1980 |
Asthma in pregnancy: current concepts.
Topics: Acute Disease; Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Beclomethasone; Cromolyn Sodium; | 1980 |
Asthma in children--our challenge.
Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adrenergic beta-Agonists; Airway Obstr | 1980 |
Combined beta-stimulator and theophylline therapy.
Topics: Adrenergic beta-Agonists; Asthma; Bronchitis; Chronic Disease; Double-Blind Method; Drug Therapy, Co | 1980 |
Treatment of chronic asthma in children with a sustained-release preparation of theophylline in addition to beta 2-stimulating agents.
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Child; Chronic Disease; Delayed-Action Preparations; D | 1980 |
The Illinois Lung Association's first asthma camp.
Topics: Asthma; Histamine H1 Antagonists; Humans; Illinois; Prednisone; Theophylline | 1980 |
Effects of different drugs on exercise induced asthma (EIA).
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Asthma; Asthma, Exercise-Induced; Cromolyn S | 1980 |
Combined vs. sequential vs. single-entity therapy.
Topics: Albuterol; Aminophylline; Asthma; Beclomethasone; Drug Therapy, Combination; Ephedrine; Epinephrine; | 1981 |
Has the change to beta-agonists combined with oral theophylline increased cases of fatal asthma?
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Asthma; Child; Death, Sudden; | 1981 |
Drug interactions and asthma deaths.
Topics: Adrenergic beta-Agonists; Asthma; Drug Interactions; Humans; Theophylline | 1981 |
Has the change to beta-agonists combined with oral theophylline increased cases of fatal asthma?
Topics: Adrenergic beta-Agonists; Asthma; Drug Therapy, Combination; Humans; Theophylline | 1981 |
[Treatment of bronchial asthma].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Aminophylline; Asthma; Cromolyn Sodium | 1981 |
Oral theophylline and fatal asthma.
Topics: Administration, Oral; Adult; Aged; Asthma; Female; Humans; Male; Middle Aged; Theophylline | 1981 |
Asthma deaths.
Topics: Adrenergic beta-Antagonists; Asthma; Humans; New Zealand; Theophylline | 1981 |
The effects of histamine, antihistamines, isoproterenol and theophylline on the Fc and complement receptor functions of polymorphonuclear leukocytes in asthmatic children.
Topics: Adolescent; Asthma; Child; Child, Preschool; Cimetidine; Diphenhydramine; Histamine; Histamine H1 An | 1981 |
Asthma deaths and theophylline/beta2-agonist therapy.
Topics: Adrenergic beta-Agonists; Asthma; Drug Interactions; Heart; Humans; Theophylline | 1981 |
Theophylline, beta-agonists, and fatal asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Drug Interactions; Humans; Middle Aged; Theophy | 1981 |
American Academy of Pediatrics. Section on Allergy and Immunology. Management of asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Allergy and Immunology; Ast | 1981 |
Bronchodilators.
Topics: Administration, Intranasal; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchitis; B | 1981 |
beta 2-Adrenoceptor stimulants and theophylline in asthma therapy.
Topics: Administration, Oral; Adrenergic beta-Agonists; Aerosols; Albuterol; Aminophylline; Asthma; Bronchod | 1981 |
Slow-reacting substances and asthma: leukotrienes may hold the key to asthma therapy.
Topics: Adrenergic beta-Agonists; Animals; Arachidonic Acids; Asthma; Autacoids; Cromolyn Sodium; Humans; Lu | 1981 |
[Treatment of the asthmatic crisis].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Female; Humans; Male; Pregnancy; Theop | 1982 |
Some recent advances in the management of asthma.
Topics: Adrenergic beta-Agonists; Aminophylline; Asthma; Bronchodilator Agents; Cromolyn Sodium; Drug Therap | 1982 |
Childhood asthma: treatment and severity.
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Child; Chronic Disease; Cromolyn Sodium; Humans; Stero | 1982 |
Combined use of beta-adrenergic agonists and methyl xanthines.
Topics: Adrenergic beta-Agonists; Aminophylline; Animals; Asthma; Dogs; Heart; Heart Diseases; Humans; Insul | 1982 |
[Bronchial asthma--causal and symptomatic treatment (author's transl)].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Histamine H1 Antagonists; Humans; Para | 1982 |
[Long-term asthma therapy--recurrences often preprogrammed. Experiences and recommendations].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Asthma; Dose-Response Relationship, Dru | 1982 |
Effect of antihistamine on pulmonary function of children with asthma.
Topics: Adolescent; Adult; Asthma; Child; Chlorpheniramine; Double-Blind Method; Female; Histamine H1 Antago | 1982 |
Combined use of theophylline and beta-2-agonists in asthma.
Topics: Administration, Oral; Adrenergic beta-Agonists; Aerosols; Asthma; Drug Therapy, Combination; Humans; | 1982 |
Dangers of compound drugs and intravenous aminophylline.
Topics: Aminophylline; Asthma; Drug Combinations; Female; Humans; Injections, Intravenous; Theophylline | 1982 |
Combined beta agonists and methylxanthines in asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Child; Child, Preschool; Drug Therapy, Combinat | 1982 |
Improved efficacy and safety of theophylline in the control of airways hyperreactivity.
Topics: Acute Disease; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Asthma; Bronchodilator Agents; Chi | 1982 |
Asthma in children: evaluation and treatment.
Topics: Adrenergic beta-Agonists; Asthma; Child; Humans; Immunotherapy; Theophylline | 1982 |
[Risk evaluation and management of the pregnant asthmatic].
Topics: Adrenergic beta-Agonists; Asthma; Cromolyn Sodium; Female; Humans; Hydrocortisone; Ketotifen; Pregna | 1982 |
Theophylline: short term treatment.
Topics: Adrenergic beta-Antagonists; Airway Obstruction; Asthma; Humans; Theophylline | 1981 |
Asthma at night.
Topics: Asthma; Circadian Rhythm; Delayed-Action Preparations; Humans; Middle Aged; Sleep; Theophylline | 1983 |
Relationship between serum theophylline levels and pulmonary function before and after inhaled beta-agonist in "stable" asthmatics.
Topics: Administration, Intranasal; Adrenergic beta-Agonists; Adult; Airway Resistance; Asthma; Dose-Respons | 1983 |
[Long-term therapy of bronchial asthma].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Bacterial Agents; Antitussive Agents; | 1983 |
Asthma therapy. Advantages and limitations of various approaches.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Calcium Channel Blockers; | 1983 |
Theophylline assay on dried blood spots.
Topics: Asthma; Blood Specimen Collection; Fluorometry; Humans; Theophylline | 1983 |
Methylxanthines in asthma.
Topics: Adrenergic beta-Agonists; Asthma; Humans; Kinetics; Phosphodiesterase Inhibitors; Terbutaline; Theop | 1983 |
Combined beta agonists and methylxanthines in asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Child; Child, Preschool; Drug Therapy, Combinat | 1983 |
Theophylline benefits and difficulties.
Topics: Adult; Asthma; Bronchitis; Child; Humans; Theophylline | 1983 |
Theophylline prescribing, serum concentrations, and toxicity.
Topics: Administration, Oral; Aminophylline; Asthma; Bronchitis; Delayed-Action Preparations; Female; Humans | 1983 |
[Medical care strategy of allergic bronchial asthma and other immunologically-induced lung diseases].
Topics: Adrenergic beta-Agonists; Alveolitis, Extrinsic Allergic; Asthma; Desensitization, Immunologic; Huma | 1983 |
Theophylline toxicity.
Topics: Asthma; Drug Interactions; Humans; Theophylline | 1983 |
[Biochemical and pharmacologic factors in the regulation of bronchial tone and their clinical significance].
Topics: Adrenergic beta-Agonists; Airway Resistance; Animals; Asthma; Bronchi; Calcium; Humans; Muscle Tonus | 1983 |
Exercise-induced asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Aerosols; Asthma; Asthma, Exercise-Induced; Body Temperature R | 1983 |
Further problems with theophylline.
Topics: Asthma; Child, Preschool; Female; Humans; Theophylline | 1984 |
Learning and behaviour problems associated with theophylline therapy.
Topics: Asthma; Child; Child Behavior; Child, Preschool; Double-Blind Method; Female; Humans; Infant; Learni | 1984 |
[Mechanism of action of anti-asthma drugs].
Topics: Adrenergic beta-Agonists; Asthma; Cromolyn Sodium; Cyclic AMP; Glucocorticoids; Humans; Mast Cells; | 1984 |
[Drug treatment of children with CARA].
Topics: Adrenergic beta-Agonists; Asthma; Child; Child, Preschool; Cromolyn Sodium; Glucocorticoids; Humans; | 1983 |
Pharmacotherapy of asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Cromolyn Sodium; Drug Therapy, Combinatio | 1984 |
Managing asthma during pregnancy.
Topics: Adrenergic beta-Agonists; Anti-Bacterial Agents; Asthma; Female; Glucocorticoids; Hemodynamics; Huma | 1984 |
Beta-adrenergic drugs in the management of asthma in athletes.
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Asthma, Exercise-Induced; Dose-Response Relationship, D | 1984 |
Behavioural problems in children taking theophylline.
Topics: Adult; Asthma; Caffeine; Child; Child Behavior Disorders; Depressive Disorder; Female; Humans; Theop | 1984 |
Absence of bronchodilatory effect from etamiphylline.
Topics: Asthma; Bronchodilator Agents; Evaluation Studies as Topic; Humans; Theophylline | 1984 |
Drug treatment in acute asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aminophylline; Anti-Bacterial Agents; Asthma; Hum | 1984 |
Treatment of chronic asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Child, Preschool; Chroni | 1984 |
Circulating beta-adrenoceptor blocking factors in asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Binding Sites; Eosinophilia; Humans; L | 1984 |
Asthma management. New perspectives, improved options.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Calcium Channel Blockers; Cromolyn Sodium | 1984 |
Treating the elderly asthmatic patient.
Topics: Adrenal Cortex Hormones; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aged; Asthma; Bronchod | 1984 |
Direction, motivation, and successful self-management of asthma: focus on drug compliance.
Topics: Adolescent; Adrenergic beta-Agonists; Aerosols; Asthma; Attitude to Health; Child; Child, Preschool; | 1984 |
Management of "wheezy bronchitis".
Topics: Administration, Oral; Adrenergic beta-Agonists; Aerosols; Age Factors; Asthma; Bronchodilator Agents | 1984 |
Management of acute severe asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Auscultation; Child; Criti | 1984 |
Medication compliance in children with asthma.
Topics: Administration, Intranasal; Adolescent; Adrenergic beta-Agonists; Aerosols; Asthma; Beclomethasone; | 1984 |
Childhood asthma. Considerations in establishing treatment programs.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Child; Cromolyn Sodium; De | 1984 |
A pharmacological approach to the management of asthma.
Topics: Adrenergic beta-Agonists; Asthma; Humans; Peak Expiratory Flow Rate; Theophylline | 1984 |
In vitro influence of theophylline on anti-IgE-induced release from leucocytes and whole blood in asthmatic children.
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Histamine Release; Humans; Immunoglobulin E; In | 1981 |
Histamine content of sputum from patients with asthma and chronic bronchitis.
Topics: Albuterol; Animals; Asthma; Bronchitis; Carcinoma, Bronchogenic; Chronic Disease; Guinea Pigs; Hista | 1982 |
Allergic disease: how to recognize and manage three common types.
Topics: Adolescent; Asthma; Child; Cromolyn Sodium; Dermatitis, Atopic; Food Hypersensitivity; Gastrointesti | 1982 |
The role of histamine and noradrenaline in allergic and exercise induced asthma of childhood, and the effect of theophylline treatment.
Topics: Adolescent; Airway Resistance; Asthma; Asthma, Exercise-Induced; Child; Epinephrine; Female; Histami | 1982 |
[Pharmacokinetics of theophylline in infantile bronchial asthma. Clinical findings].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Asthma; Bronchi; Child; Child, Preschool; Cilia; Dose-Response | 1982 |
Effect of calcium antagonists in experimental asthma.
Topics: Anaphylaxis; Animals; Asthma; Calcium Channel Blockers; Depression, Chemical; Disease Models, Animal | 1982 |
Diagnosis and treatment of allergic rhinitis and asthma in infancy and childhood.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Environment, Controlled; Histamine H1 | 1984 |
A comparison of late reactions to antigen and exercise.
Topics: Albuterol; Antigens; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Chemotactic Fact | 1984 |
[Inhibition of anti-IgE-stimulated histamine liberation from sensitized leukocytes of patients with allergic bronchial asthma treated with theophylline].
Topics: Asthma; Histamine Release; Humans; Immunization; Immunoglobulin E; Leukocytes; Theophylline | 1984 |
Theophyllines--a review.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Biological Availability; Child; Child, Preschool; D | 1984 |
[Asthma therapy in medical practice].
Topics: Adrenal Cortex Hormones; Asthma; Cephalosporins; Cromolyn Sodium; Expectorants; Humans; Ipratropium; | 1982 |
Induction of suppressor T cells in asthmatic children by theophylline treatment.
Topics: Adolescent; Asthma; Child; Female; Graft vs Host Reaction; Humans; Leukocyte Count; Lymphocyte Activ | 1983 |
[Treatment of asthma].
Topics: Asthma; Cromolyn Sodium; Desensitization, Immunologic; Glucocorticoids; Humans; Ipratropium; Sympath | 1984 |
Practical use of theophylline in children with asthma.
Topics: Asthma; Child; Humans; Kinetics; Theophylline | 1984 |
Comparison of the effects of theophylline, prednisolone and sleep withdrawal on airway obstruction and urinary cyclic AMP/cyclic GMP excretion of asthmatic children with and without nocturnal asthma.
Topics: Adolescent; Airway Obstruction; Asthma; Child; Circadian Rhythm; Cyclic AMP; Cyclic GMP; Female; Hum | 1980 |
Universal adenosine receptor antagonism is neither necessary nor desirable with xanthine antiasthmatics.
Topics: Adenosine; Airway Resistance; Animals; Asthma; Central Nervous System; Diuresis; Dose-Response Relat | 1982 |
[Status asthmaticus].
Topics: Adrenocorticotropic Hormone; Asthma; Expectorants; Humans; Oxygen Inhalation Therapy; Prednisone; Th | 1982 |
Effect of sustained-release theophylline administration on pituitary-thyroid axis.
Topics: Adolescent; Asthma; Child; Child, Preschool; Cyclic AMP; Delayed-Action Preparations; Female; Humans | 1982 |
Lymphocyte beta-adrenergic refractoriness induced by theophylline or metaproterenol in healthy and asthmatic subjects.
Topics: Asthma; Cyclic AMP; Dihydroalprenolol; Drug Therapy, Combination; Humans; Lymphocytes; Male; Metapro | 1982 |
[Comparison of bronchodilating and metabolic effects of intravenous aminophylline and subcutaneous epinephrine individually and in combination in patients with bronchial asthma].
Topics: Adult; Aged; Aminophylline; Asthma; Bronchodilator Agents; Cyclic AMP; Drug Therapy, Combination; Ep | 1982 |
Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects.
Topics: Adenosine; Adolescent; Adult; Aged; Airway Resistance; Asthma; Bronchi; Constriction, Pathologic; Cy | 1983 |
[Pharmacodynamic aspects of theophylline].
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Asthma; Cell Membrane; Che | 1983 |
Twice daily slow-release theophylline vs placebo for 'morning-dipping' in asthma.
Topics: Adult; Aged; Asthma; Circadian Rhythm; Cyclic AMP; Delayed-Action Preparations; Double-Blind Method; | 1984 |
New thoughts about the mechanisms of action of corticosteroids and theophylline in asthma.
Topics: Adrenal Cortex Hormones; Airway Resistance; Asthma; Bronchial Provocation Tests; Cyclic AMP; Histami | 1984 |
Application of substrate-labelled fluorescent immunoassay to the measurement of anticonvulsant and antiasthmatic drug levels in plasma and serum.
Topics: Anticonvulsants; Asthma; Fluorescent Antibody Technique; Humans; Plasma; Theophylline; Uremia | 1983 |
The validation of a fluoroimmunoassay for the determination of theophylline concentration in dried blood spots suitable for domiciliary therapeutic drug monitoring.
Topics: Adult; Ambulatory Care; Asthma; Blood Specimen Collection; Child; Evaluation Studies as Topic; Femal | 1984 |
Clinical evaluation of theophylline binding to plasma protein in bronchial asthmatic patients.
Topics: Asthma; Blood Proteins; Humans; Hydrogen-Ion Concentration; Immunoenzyme Techniques; Protein Binding | 1984 |
Rapid estimation of serum theophylline clearance in children with acute asthma.
Topics: Acute Disease; Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Immunoenzyme Techniques; | 1984 |
Asthma in New Zealand.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Cromolyn Sodium; Desensitization, Immunologi | 1983 |
A review of the hospital course of asthmatic children and adults.
Topics: Adolescent; Adult; Aged; Asthma; Carbon Dioxide; Child; Child, Preschool; Female; Forced Expiratory | 1983 |
[Rational asthma drug therapy].
Topics: Aminophylline; Anti-Bacterial Agents; Asthma; Bronchial Spasm; Cromolyn Sodium; Desensitization, Imm | 1983 |
[Long-term theophylline therapy of bronchial asthma].
Topics: Adolescent; Asthma; Child; Child, Preschool; Humans; Infant; Long-Term Care; Theophylline | 1983 |
[Drug information: Uniphylline. Rhythm therapy of bronchial asthma].
Topics: Asthma; Delayed-Action Preparations; Humans; Theophylline | 1983 |
Chronic and acute asthma. Keys to successful management.
Topics: Administration, Oral; Adolescent; Adrenal Cortex Hormones; Aminophylline; Asthma; Asthma, Exercise-I | 1984 |
Intravenous aminophylline in acutely ill patients receiving theophylline.
Topics: Adolescent; Aminophylline; Asthma; Child; Child, Preschool; Drug Administration Schedule; Drug Thera | 1984 |
[Possibilities for optimizing therapy with theophylline preparations. Clinical effectiveness and side effects of microcrystalline theophylline].
Topics: Adult; Asthma; Female; Forced Expiratory Volume; Humans; Kinetics; Long-Term Care; Lung Diseases, Ob | 1984 |
ABC of asthma. Asthma in children: treatment.
Topics: Acute Disease; Aerosols; Asthma; Beclomethasone; Budesonide; Child; Child, Preschool; Cromolyn Sodiu | 1984 |
"Great Expectations"-defined and refined.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Child; Child, Preschool; Consumer Behavior; Cromolyn So | 1984 |
The effects of increasing the evening dose of controlled release theophylline in patients with reversible airways obstruction.
Topics: Adult; Aged; Asthma; Delayed-Action Preparations; Drug Administration Schedule; Humans; Middle Aged; | 1984 |
The influence of controlled release theophylline on cold air induced bronchoconstriction in asthma.
Topics: Adult; Asthma; Bronchi; Cold Temperature; Delayed-Action Preparations; Humans; Middle Aged; Pulmonar | 1984 |
Serum theophylline levels in children after a single dose of Uniphyllin Unicontin tablets.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Humans; Theophylline | 1984 |
Trends in sales of drugs for asthma in New Zealand, Australia, and the United Kingdom, 1975-81.
Topics: Adolescent; Adult; Aerosols; Asthma; Australia; Child; Child, Preschool; Cromolyn Sodium; Drug Utili | 1984 |
Doses of aminophylline given intravenously in casualty department and resulting serum theophylline concentrations.
Topics: Aged; Aminophylline; Asthma; Emergencies; Emergency Service, Hospital; England; Female; Humans; Inje | 1984 |
Circadian variation in the absorption of three sustained release theophylline products in asthmatic children and the effect of food on absorption of Somophyllin-CRT.
Topics: Asthma; Biological Availability; Child; Circadian Rhythm; Delayed-Action Preparations; Food; Humans; | 1984 |
Food and fasting intake of sustained release theophylline preparations.
Topics: Adult; Asthma; Biological Availability; Delayed-Action Preparations; Fasting; Food; Humans; Intestin | 1984 |
Clinical aspects of sustained release theophylline therapy: chairman's opening remarks.
Topics: Asthma; Child; Delayed-Action Preparations; Humans; Theophylline | 1984 |
A comparison of the plasma profiles of two slow release theophylline preparations in asthmatic patients and healthy volunteers.
Topics: Adolescent; Adult; Aged; Asthma; Biological Availability; Delayed-Action Preparations; Female; Human | 1984 |
Dose-effect relationship of a controlled release theophylline preparation in pre-school children.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Dose-Response Relationship, Drug; Huma | 1984 |
Circadian rhythms in theophylline pharmacokinetics and pharmacodynamics in asthmatic children.
Topics: Asthma; Child; Circadian Rhythm; Delayed-Action Preparations; Humans; Intestinal Absorption; Kinetic | 1984 |
Use of sustained release Somophyllin-12 capsules in young asthmatic children.
Topics: Asthma; Child, Preschool; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; Male | 1984 |
Doses of aminophylline given intravenously in casualty.
Topics: Administration, Oral; Aminophylline; Asthma; Humans; Infusions, Parenteral; Theophylline | 1984 |
[Serum levels, dose and response in prolonged treatment with theophylline].
Topics: Adolescent; Adult; Aged; Asthma; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Long-T | 1984 |
Iodide containing theophylline products.
Topics: Acne Vulgaris; Adolescent; Asthma; Drug Combinations; Female; Goiter; Humans; Infant, Newborn; Iodid | 1980 |
Management of childhood asthma.
Topics: Adrenal Cortex Hormones; Allergens; Asthma; Beclomethasone; Child; Cromolyn Sodium; Dust; Humans; Im | 1980 |
A comparison of cell-mediated immunity and suppressor T-cell function in asthmatic and normal children.
Topics: Asthma; Child; Concanavalin A; Female; Humans; Immunity, Cellular; Immunoglobulin E; Male; Phytohema | 1980 |
Adenosine as a bronchoconstrictor mediator in asthma and its antagonism by methylxanthines.
Topics: Adenosine; Asthma; Bronchi; Humans; Immunoglobulin E; Mast Cells; Theophylline; Xanthines | 1984 |
Rational dosage of intravenous aminophylline for Thai asthmatic children.
Topics: Adolescent; Aminophylline; Asthma; Child; Female; Humans; Infusions, Parenteral; Male; Theophylline | 1984 |
Drug intake and plasma concentrations in acute asthma.
Topics: Acute Disease; Administration, Oral; Aerosols; Albuterol; Asthma; Ethanolamines; Female; Fenoterol; | 1984 |
Use of pharmacokinetic profile in evaluating patients with repeatedly low theophylline concentrations.
Topics: Asthma; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Kinetics; Theophylline | 1984 |
Theophylline dose prediction.
Topics: Adolescent; Asthma; Child; Child, Preschool; Drug Administration Schedule; Humans; Theophylline | 1984 |
Once a day theophylline; serum concentrations.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Humans; Theophylline; Time Factors | 1984 |
The relationship between pharmacodynamics and pharmacokinetics in asthmatic children receiving a sustained-release formulation of theophylline.
Topics: Adolescent; Airway Resistance; Asthma; Child; Delayed-Action Preparations; Female; Forced Expiratory | 1984 |
Pharmacokinetics and pharmacodynamics of three sustained-release theophylline preparations (350 mg Theograd, 350 mg Theolair Retard and 300 mg Theodur) in steady state in healthy volunteers and asthmatics--Part I: Theophylline plasma levels.
Topics: Adult; Alcohol Drinking; Asthma; Biological Availability; Delayed-Action Preparations; Female; Human | 1984 |
[Interaction between theophylline and cimetidine. Effect of cimetidine on the serum clearance of theophylline].
Topics: Adult; Aged; Asthma; Cimetidine; Drug Interactions; Female; Humans; Male; Middle Aged; Theophylline | 1984 |
Sustained-release anhydrous theophylline in preventing exercise-induced asthma.
Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Child; Delayed-Action Preparations; Double-Blin | 1984 |
[Importance of salivary levels of theophylline in monitoring pediatric asthmatic patients].
Topics: Administration, Oral; Adolescent; Asthma; Child; Child, Preschool; Humans; Infant; Monitoring, Physi | 1984 |
Pharmacokinetics of theophylline in asthmatic children after multiple oral doses of aminophylline tablets.
Topics: Aminophylline; Asthma; Child; Child, Preschool; Female; Humans; Kinetics; Male; Tablets; Theophyllin | 1984 |
Serum theophylline levels in young children receiving a sustained-release theophylline tablet.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Male; | 1984 |
Realistic expectations: a look at childhood asthma in the 1980s.
Topics: Ambulatory Care; Asthma; Child; Humans; Pennsylvania; Status Asthmaticus; Theophylline | 1984 |
Effect of compliance for chronic asthmatic children.
Topics: Asthma; Child; Chronic Disease; Female; Humans; Male; Patient Compliance; Peak Expiratory Flow Rate; | 1984 |
Theophylline increases serum uric acid levels.
Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Erythrocytes; Female; Humans; Hypoxanthi | 1984 |
[Rational use of theophylline in asthma in children].
Topics: Age Factors; Asthma; Asthma, Exercise-Induced; Child; Child, Preschool; Humans; Infant; Kinetics; Th | 1984 |
Dose-dependent kinetics of theophylline in adults with pulmonary diseases.
Topics: Adult; Aged; Aminophylline; Asthma; Dose-Response Relationship, Drug; Female; Humans; Infusions, Par | 1984 |
Cimetidine-methylprednisolone-theophylline metabolic interaction.
Topics: Adult; Asthma; Biological Availability; Biotransformation; Cimetidine; Drug Interactions; Female; Hu | 1984 |
Inadequacy of FDA dosing guidelines for intravenous theophylline.
Topics: Adult; Aged; Asthma; Female; Humans; Infusions, Parenteral; Injections, Intravenous; Male; Middle Ag | 1984 |
[Comparative study of the effect of a single oral dose of theophylline and etamiphyllin in children with asthma].
Topics: Administration, Oral; Adolescent; Albuterol; Asthma; Child; Double-Blind Method; Drug Evaluation; Fo | 1984 |
Macrolide antibiotics and serum theophylline levels in relation to the severity of respiratory impairment: a comparison between the effects of erythromycin and josamycin.
Topics: Aged; Asthma; Bronchitis; Drug Interactions; Erythromycin; Female; Humans; Leucomycins; Male; Middle | 1984 |
[Bronchodilator effects of an atropinic compound: oxitropium pressurized aerosol. Comparison with theophylline in asthma].
Topics: Aerosols; Asthma; Bronchodilator Agents; Humans; Parasympatholytics; Scopolamine Derivatives; Theoph | 1984 |
Asthma in New Zealand: a response.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Humans; Hypoxia; New Zealand; Patient Educat | 1983 |
[Recommendations for the treatment of status asthmaticus in private and clinical practice].
Topics: Acute Disease; Aerosols; Anti-Bacterial Agents; Asthma; Fluid Therapy; Hospitalization; Humans; Hypn | 1983 |
Prospects for inhaled xanthines in asthma.
Topics: Aerosols; Aminophylline; Asthma; Humans; Theophylline | 1983 |
Adenosine antagonism as an alternative mechanism of action of methylxanthines in asthma.
Topics: Adenosine; Adenosine Monophosphate; Airway Resistance; Asthma; Bronchi; Dose-Response Relationship, | 1983 |
[Appraisal of the efficacy of hyposensitization in extrinsic asthmatics].
Topics: Adult; Asthma; Desensitization, Immunologic; Evaluation Studies as Topic; Female; Humans; Male; Midd | 1983 |
Simultaneous treatment with terbutaline and theophylline.
Topics: Adult; Aged; Asthma; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Forced | 1984 |
Theophylline--clinical pharmacokinetics and therapeutic drug monitoring.
Topics: Adolescent; Adult; Aged; Asthma; Biological Availability; Child; Child, Preschool; Dose-Response Rel | 1984 |
Oral theophylline and asthma.
Topics: Acute Disease; Administration, Oral; Adult; Asthma; Child; Delayed-Action Preparations; Humans; New | 1984 |
The effect of aminophylline, oxyphylline and fenoterol on some ventilatory functions in patients with reversible airways obstruction.
Topics: Aminophylline; Asthma; Ethanolamines; Fenoterol; Humans; Respiratory Function Tests; Theophylline | 1983 |
Pharmacokinetic optimisation of aminophylline infusions in critically ill patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminophylline; Asthma; Biological Availability; Bronchial Sp | 1983 |
[Bronchial asthma].
Topics: Airway Obstruction; Asthma; Electrocardiography; Humans; Oxygen; Respiratory Insufficiency; Theophyl | 1983 |
Practical considerations in the safe and effective use of theophylline.
Topics: Asthma; Biological Availability; Biotransformation; Child; Delayed-Action Preparations; Dosage Forms | 1983 |
Relation between positive small air ions, weather fronts and pulmonary function in patients with bronchial asthma.
Topics: Aerosols; Air Pollution; Anions; Asthma; Cations; Female; Humans; Ions; Lung; Male; Peak Expiratory | 1983 |
[Monitoring of plasma theophylline levels in asthmatic patients treated with oxtriphylline].
Topics: Adolescent; Adult; Aged; Asthma; Biological Availability; Child; Choline; Female; Humans; Male; Midd | 1983 |
[Clinical efficacy and immunological mechanisms of the effect of hemodes in patients with bronchial asthma].
Topics: Adolescent; Adult; Antibody Formation; Asthma; Drug Resistance; Female; Humans; Immunity, Cellular; | 1983 |
[Therapy with theophylline].
Topics: Administration, Oral; Asthma; Biological Availability; Humans; Theophylline | 1983 |
[Individualized dosage of theophylline for ambulatory asthmatic patients].
Topics: Adult; Aged; Asthma; Female; Humans; Male; Middle Aged; Theophylline | 1983 |
Interaction of theophylline with erythromycin base in a patient with seizure activity.
Topics: Asthma; Bronchitis; Child; Drug Interactions; Erythromycin; Female; Half-Life; Humans; Metabolic Cle | 1983 |
News aspects of oral theophylline.
Topics: Airway Resistance; Asthma; Drug Therapy, Combination; Humans; Theophylline | 1983 |
Theophylline--plasma concentration related to bronchodilatation and side effects.
Topics: Airway Resistance; Asthma; Humans; Theophylline | 1983 |
[Theophylline: plasma levels in asthma patients treated with choline theophyllinate every 8 hours].
Topics: Adolescent; Adult; Aged; Asthma; Child; Drug Administration Schedule; Female; Humans; Male; Middle A | 1983 |
[Effect of oral aminophylline on the result of the immediate intradermal skin test in asthmatic children--its relation to the serum theophylline level].
Topics: Administration, Oral; Adolescent; Age Factors; Aminophylline; Asthma; Child; Child, Preschool; Femal | 1983 |
[Sustained-action oral theophylline in the asthmatic child. Clinical, pharmacokinetic and respiratory function studies].
Topics: Administration, Oral; Adolescent; Age Factors; Asthma; Child; Child, Preschool; Circadian Rhythm; De | 1983 |
Plasma theophylline levels in asthmatic children in Singapore. A preliminary study.
Topics: Administration, Oral; Aminophylline; Asthma; Bronchodilator Agents; Child; Child, Preschool; Choline | 1983 |
Symptoms and peak expiratory flow rate: response to a slow release theophylline preparation.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Male; Peak Expiratory | 1983 |
Theophylline concentrations in the emergency treatment of acute bronchial asthma.
Topics: Acute Disease; Adolescent; Adult; Asthma; Emergencies; Humans; Theophylline | 1983 |
Bioavailability and diurnal variation in absorption of sustained release theophylline in asthmatic children.
Topics: Adolescent; Asthma; Biological Availability; Child; Child, Preschool; Circadian Rhythm; Delayed-Acti | 1983 |
Sustained-release theophylline preparations. A comparative survey of 467 patients.
Topics: Asthma; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Patient Compliance; Smoking; | 1984 |
Prediction of serum theophylline levels.
Topics: Adolescent; Adult; Aged; Asthma; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Theo | 1984 |
Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined.
Topics: Adult; Aged; Aging; Asthma; Blood Proteins; Bronchitis; Child; Child, Preschool; Female; Humans; Inf | 1984 |
Gynecomastia associated with theophylline.
Topics: Asthma; Gynecomastia; Humans; Male; Middle Aged; Theophylline | 1984 |
Increased theophylline clearance in a patient with hyperthyroidism.
Topics: Asthma; Humans; Hyperthyroidism; Kinetics; Male; Middle Aged; Theophylline | 1984 |
Serum theophylline during acute asthmatic attacks.
Topics: Acute Disease; Adult; Aged; Asthma; Bronchitis; Chronic Disease; Female; Humans; Kinetics; Male; Mid | 1984 |
The bronchodilator effects and pharmacokinetics of caffeine in asthma.
Topics: Adolescent; Asthma; Bronchodilator Agents; Caffeine; Child; Double-Blind Method; Humans; Kinetics; R | 1984 |
Hypothyroidism with coexistent asthma: problems in management.
Topics: Acute Disease; Asthma; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Hypothyroidis | 1984 |
Asthma and irreversible airflow obstruction.
Topics: Adult; Age Factors; Albuterol; Asthma; Chronic Disease; Female; Forced Expiratory Volume; Humans; Lu | 1984 |
Long term treatment with theophylline increases malonyl dialdehyde plasma concentrations.
Topics: Adolescent; Adult; Asthma; Delayed-Action Preparations; Humans; Kinetics; Lipolysis; Malonates; Malo | 1984 |
Adenosine-induced bronchoconstriction in asthma. Antagonism by inhaled theophylline.
Topics: Adenosine; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Dose-Response Relationship | 1984 |
Effect of isoproterenol on measured theophylline levels.
Topics: Adolescent; Asthma; Child; Child, Preschool; Drug Interactions; Humans; Isoproterenol; Theophylline | 1984 |
Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline.
Topics: Administration, Oral; Adolescent; Adult; Airway Obstruction; Aminophylline; Asthma; Double-Blind Met | 1984 |
[Choice of bronchodilators].
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Humans; Lung Diseases, Obstructive; Muscle T | 1984 |
Inhibition of exercise-induced asthma by theophylline.
Topics: Asthma; Asthma, Exercise-Induced; Drug Administration Schedule; Humans; Lung; Muscle Contraction; Th | 1984 |
[Possibilities for optimizing therapy with theophylline preparations. III. Ventilatory effect and pharmacokinetics of "new" Pulmophyllin].
Topics: Adult; Aminophylline; Antipyrine; Asthma; Double-Blind Method; Drug Combinations; Female; Forced Exp | 1984 |
[Possibilities for optimizing therapy with theophylline preparations. I. On the pharmacokinetics of theophylline preparations].
Topics: Adult; Aminophylline; Asthma; Biological Availability; Delayed-Action Preparations; Female; Humans; | 1984 |
Cardiopulmonary responses of asthmatic children to strenuous exercise. Effect of theophylline.
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Child; Electrocardiography; Female; Heart Rate; Humans | 1984 |
Bronchoalveolar lavage. Its safety in subjects with mild asthma.
Topics: Adult; Aminophylline; Asthma; Bronchi; Bronchial Provocation Tests; Bronchoscopy; Evaluation Studies | 1984 |
Gastroesophageal reflux and asthma.
Topics: Asthma; Child; Gastroesophageal Reflux; Humans; Theophylline | 1984 |
Theophylline therapy. Titrating dosage requirements.
Topics: Administration, Oral; Adolescent; Age Factors; Asthma; Cardiovascular Diseases; Child; Child, Presch | 1984 |
Individualizing theophylline dosage: evaluation of a single-point maintenance dose prediction method.
Topics: Adolescent; Adult; Asthma; Bronchitis; Computers; Female; Half-Life; Humans; Male; Middle Aged; Mode | 1984 |
Treatment of acute asthma in children with rectal administration of aminophylline solution.
Topics: Acute Disease; Asthma; Child; Double-Blind Method; Female; Humans; Intestinal Absorption; Kinetics; | 1984 |
Drug abuse and the asthmatic patient: a case report.
Topics: Adolescent; Asthma; Female; Humans; Personality; Substance-Related Disorders; Theophylline | 1984 |
Comparison at steady state of sustained-release theophylline tablets and capsules.
Topics: Adult; Aminophylline; Asthma; Capsules; Delayed-Action Preparations; Female; Humans; Immunoenzyme Te | 1982 |
[Determination of theophylline concentration in serum and saliva].
Topics: Asthma; Dose-Response Relationship, Drug; Humans; Kinetics; Saliva; Theophylline | 1982 |
[Clinical pharmacology of theophylline].
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Infant | 1982 |
Errors in the treatment of asthma.
Topics: Adrenal Cortex Hormones; Aminophylline; Asthma; Bronchodilator Agents; Cromolyn Sodium; Epinephrine; | 1980 |
Cromolyn sodium and theophylline in chronic perennial asthma.
Topics: Asthma; Cromolyn Sodium; Humans; Theophylline | 1980 |
Asthma and its treatment.
Topics: Adrenal Cortex Hormones; Aerosols; Asthma; Cromolyn Sodium; Humans; Sympathomimetics; Theophylline | 1980 |
Outpatient treatment of asthma in children.
Topics: Adrenal Cortex Hormones; Ambulatory Care; Asthma; Beclomethasone; Child; Cromolyn Sodium; Humans; Lu | 1980 |
[Drugs for the treatment of asthma. Part II: Theophylline, disodium cromoglycate and steroids (author's transl)].
Topics: Adrenal Cortex Hormones; Asthma; Cromolyn Sodium; Humans; Theophylline | 1980 |
Clinical pharmacology of drugs used for asthma.
Topics: Acute Disease; Administration, Oral; Adrenal Cortex Hormones; Aerosols; Airway Obstruction; Asthma; | 1981 |
Pulmonary infiltrates and eosinophilia in a patient with long-standing asthma.
Topics: Adult; Aspergillosis, Allergic Bronchopulmonary; Asthma; Diagnosis, Differential; Humans; Isoetharin | 1981 |
Use of serum theophylline determinations during acute asthma therapy in children.
Topics: Acute Disease; Adolescent; Adult; Aging; Analysis of Variance; Asthma; Child; Child, Hospitalized; C | 1982 |
Outpatient treatment of asthma.
Topics: Asthma; Beclomethasone; Cromolyn Sodium; Humans; Sympathomimetics; Theophylline | 1982 |
[Bronchial asthma in children].
Topics: Adrenal Cortex Hormones; Asthma; Child; Cromolyn Sodium; Desensitization, Immunologic; Humans; Ketot | 1982 |
Drugs for asthma.
Topics: Asthma; Beclomethasone; Cromolyn Sodium; Drug Combinations; Epinephrine; Humans; Isoproterenol; Theo | 1982 |
Safety, efficacy and bronchodilator-sparing effects of nebulized cromolyn sodium solution in the treatment of asthma in children.
Topics: Administration, Intranasal; Asthma; Bronchodilator Agents; Child; Child, Preschool; Cromolyn Sodium; | 1982 |
Pharmacological rehabilitation of the asthmatic child.
Topics: Asthma; Asthma, Exercise-Induced; Bronchi; Bronchial Provocation Tests; Child; Cromolyn Sodium; Huma | 1981 |
Pharmacokinetics of a new theophylline liquid in asthmatic children.
Topics: Adolescent; Asthma; Child; Female; Humans; Kinetics; Male; Theophylline | 1983 |
Responses of the pulmonary artery to asthma-drugs.
Topics: Asthma; Bronchi; Humans; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth; Mus | 1983 |
Reduced theophylline half-life induced by carbamazepine therapy.
Topics: Asthma; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Half-Life; Humans; Theophylline | 1983 |
Suggestion of need for higher therapeutic levels of serum theophylline to achieve optimal therapeutic response.
Topics: Asthma; Humans; Theophylline | 1983 |
Effects of oral theophylline and oral salbutamol in the treatment of asthma.
Topics: Albuterol; Asthma; Child; Humans; Theophylline | 1983 |
Mechanical ventilation in severe exacerbation of asthma. Study of 26 cases with six deaths.
Topics: Adolescent; Adult; Age Factors; Aged; Asthma; Female; Humans; Male; Methylprednisolone; Middle Aged; | 1983 |
Rapid and sustained oral theophylline loading. An alternative to intravenous aminophylline therapy.
Topics: Administration, Oral; Adult; Asthma; Delayed-Action Preparations; Female; Headache; Humans; Male; Th | 1983 |
[Use of bronchodilators in the therapy of obstructive respiratory diseases].
Topics: Aerosols; Asthma; Atropine Derivatives; Bronchitis; Bronchodilator Agents; Humans; Lung Diseases, Ob | 1983 |
Theophylline administration in children with asthma: optimal pulmonary function and possible tolerance to chronic administration.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Drug Tolerance; Female; Forced Expiratory Vo | 1983 |
Bioavailability of sustained-release theophylline granules in apple sauce in pediatric asthmatic patients.
Topics: Asthma; Biological Availability; Child; Delayed-Action Preparations; Female; Fruit; Humans; Male; Th | 1983 |
Assessment of acute asthma in the emergency room: evaluation of compliance and combined drug therapy.
Topics: Adolescent; Asthma; Bronchial Spasm; Child; Child, Preschool; Drug Therapy, Combination; Emergencies | 1983 |
Aspirin-sensitive rhinosinusitis/asthma: spectrum of adverse reactions to aspirin.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aspirin; Asthma; Drug Hypersensitivity; Forced Exp | 1983 |
[Dosage of intravenous theophyllamine].
Topics: Asthma; Humans; Injections, Intravenous; Theophylline | 1983 |
[The use of theophylline retard in asthmatic children].
Topics: Age Factors; Asthma; Child; Delayed-Action Preparations; Humans; Theophylline | 1983 |
[Continuous treatment of asthma in children with theophylline retard].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Dose-Response Relationship | 1983 |
Prediction of optimum oral theophylline dose in patients with obstructive airways disease.
Topics: Adult; Aged; Asthma; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Models, Biologic | 1983 |
Cathodally migrating creatine kinase in sera of patients treated with theophylline, and its diagnostic implications.
Topics: Adolescent; Adult; Aged; Asthma; Child; Child, Preschool; Chromatography, Ion Exchange; Creatine Kin | 1983 |
Reviewing bronchial asthma and its pharmacotherapy.
Topics: Adult; Aged; Aspirin; Asthma; Bronchodilator Agents; Female; Humans; Male; Patient Education as Topi | 1983 |
[Pharmacotherapy of severe asthma attacks. New aspects of conventional therapy].
Topics: Acute Disease; Adrenal Cortex Hormones; Asthma; Atropine Derivatives; Drug Therapy, Combination; Hum | 1983 |
Pharmacokinetics and pharmacodynamics of a short- and long-acting theophylline medication (theolair and Theolair retard) in normals and asthmatics. Part I: pharmacokinetics.
Topics: Adult; Asthma; Delayed-Action Preparations; Humans; Kinetics; Middle Aged; Theophylline | 1983 |
Pharmacokinetics and pharmacodynamics of a short- and long-acting theophylline medication (Theolair and Theolair retard) in normals and asthmatics. Part II: Lung function and side effects.
Topics: Adult; Asthma; Delayed-Action Preparations; Humans; In Vitro Techniques; Lung; Middle Aged; Theophyl | 1983 |
Comparative bioavailability study of theophylline tablets marketed in Australasia.
Topics: Absorption; Adolescent; Adult; Asthma; Biological Availability; Choline; Chromatography, High Pressu | 1980 |
Over-the-counter bronchodilators.
Topics: Asthma; Bronchodilator Agents; Ephedrine; Epinephrine; Female; Humans; Nonprescription Drugs; Substa | 1980 |
Theophylline. Know how to handle this potent bronchodilator.
Topics: Aminophylline; Asthma; Humans; Theophylline | 1980 |
Clinical problems in the adult with asthma.
Topics: Adult; Asthma; Catecholamines; Drug Therapy, Combination; Humans; Theophylline | 1981 |
[Therapeutic measures in asthmatic disease].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Asthma; Bronchodilator Agents; Humans; Sympathomimet | 1982 |
[Josamycin in respiratory pathology in children being treated with theophylline].
Topics: Asthma; Child; Child, Preschool; Humans; Infant; Leucomycins; Respiratory Tract Infections; Theophyl | 1982 |
Pharmacokinetics of Nuelin-SR 250 mg in asthmatic children: a new sustained-release theophylline.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Humans; Kinetics; Theophylline; Time Factors | 1980 |
Serum theophylline levels in adult asthmatics: comparison of oral sustained-release and microcrystalline preparations.
Topics: Administration, Oral; Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Delayed-Action Prepara | 1980 |
Long term theophylline therapy. Proceedings of a symposium, Copenhagen, 24th Sept 1979.
Topics: Asthma; Humans; Theophylline | 1980 |
Antibiotics and asthma therapy.
Topics: Asthma; Drug Interactions; Erythromycin; Humans; Theophylline | 1981 |
Dyphylline aerosol can induce bronchospasm in human asthmatics.
Topics: Adult; Aerosols; Aged; Asthma; Bronchial Spasm; Bronchodilator Agents; Dyphylline; Female; Forced Ex | 1982 |
Bleeding duodenal ulcer as a complication of treatment of status asthmaticus with adrenal corticosteroids.
Topics: Adolescent; Adrenal Cortex Hormones; Aminophylline; Asthma; Child; Child, Preschool; Duodenal Ulcer; | 1980 |
The clinical and pharmacological history of theophylline: first report on the bronchospasmolytic action in man by S. R. Hirsch in Frankfurt (Main) 1922.
Topics: Asthma; Bronchial Spasm; Cardiology; Germany, West; History, 19th Century; History, 20th Century; Hu | 1982 |
[Therapy control by determination of serum drug concentrations].
Topics: Asthma; Drug Therapy; Epilepsy; Humans; Phenytoin; Quality Control; Reference Standards; Theophyllin | 1982 |
[Obstructive airway diseases in children].
Topics: Abscess; Adult; Asthma; Child; Child, Preschool; Cystic Fibrosis; Foreign-Body Reaction; Humans; Inh | 1982 |
Computer-simulated conversion from intravenous to sustained-release oral theophylline.
Topics: Administration, Oral; Adult; Asthma; Computers; Delayed-Action Preparations; Drug Administration Sch | 1982 |
Individualization of theophylline dosage using a single serum sample following a test dose.
Topics: Asthma; Child; Child, Preschool; Humans; Individuality; Theophylline; Time Factors | 1982 |
Individualization of dosage for oral theophylline therapy.
Topics: Administration, Oral; Asthma; Child; Child, Preschool; Humans; Infant; Theophylline | 1982 |
Placental theophylline transfer in pregnant asthmatics.
Topics: Adolescent; Adult; Asthma; Caffeine; Female; Fetal Blood; Fetus; Half-Life; Heart; Hemodynamics; Hum | 1982 |
Computer-assisted oral and intravenous theophylline therapy.
Topics: Administration, Oral; Adult; Aged; Asthma; Bronchitis; Computers; Humans; Injections, Intravenous; M | 1982 |
Safe and effective use of sustained-release and intravenous theophylline.
Topics: Administration, Oral; Adolescent; Adult; Aminophylline; Asthma; Child; Child, Preschool; Delayed-Act | 1982 |
Investigation of a dosage regimen for intravenous theophylline.
Topics: Adult; Asthma; Drug Administration Schedule; Half-Life; Humans; Infusions, Parenteral; Injections, I | 1982 |
Persistent cough a forme-fruste of asthma.
Topics: Adolescent; Aerosols; Albuterol; Asthma; Bronchial Spasm; Child; Child, Preschool; Cough; Eosinophil | 1982 |
Comparison of serum theophylline levels in asthmatic children receiving sustained-release and rapid-release theophylline tablets.
Topics: Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Delayed-Action Preparations; Female; H | 1982 |
Effect of intravenous isoproterenol on theophylline kinetics.
Topics: Adolescent; Animals; Asthma; Child; Child, Preschool; Dogs; Drug Interactions; Humans; Isoproterenol | 1982 |
Altered theophylline clearance during an influenza B outbreak.
Topics: Asthma; Child; Disease Outbreaks; Headache; Humans; Influenza, Human; Male; Metabolic Clearance Rate | 1982 |
Interaction between nutrition and theophylline metabolism in children.
Topics: Adolescent; Asthma; Child; Diet; Dietary Carbohydrates; Dietary Proteins; Female; Humans; Kinetics; | 1982 |
Pitfalls in the interpretation of serum theophylline levels.
Topics: Adolescent; Adult; Asthma; Child; Female; Humans; Infant; Male; Patient Compliance; Theophylline | 1982 |
Interaction of cimetidine and theophylline in two infants.
Topics: Asthma; Child, Preschool; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Infant; Theophy | 1982 |
Influence of trivalent influenza vaccine on serum theophylline levels.
Topics: Adult; Asthma; Female; Humans; Influenza Vaccines; Male; Middle Aged; Theophylline | 1982 |
Theophylline kinetics and ventilatory flow in bronchial asthma and chronic airflow obstruction: influence of erythromycin.
Topics: Adult; Aged; Asthma; Drug Interactions; Drug Therapy, Combination; Erythromycin; Female; Humans; Kin | 1982 |
Bactericidal capacity of polymorphonuclear leukocytes from patients receiving theophylline therapy.
Topics: Adolescent; Adult; Asthma; Blood Bactericidal Activity; Child; Child, Preschool; Humans; Infant; Mid | 1982 |
Management of asthma--a correction.
Topics: Adolescent; Asthma; Child; Child, Preschool; Humans; Infant; Theophylline | 1982 |
[Determination of the mean dose of oral theophylline in asthmatic children (author's transl)].
Topics: Administration, Oral; Asthma; Child; Child, Preschool; Humans; Inactivation, Metabolic; Infant; Theo | 1982 |
Theophylline. New thoughts about an old drug.
Topics: Asthma; Bronchodilator Agents; Delayed-Action Preparations; Humans; Kinetics; Theophylline | 1982 |
Acceptability and efficacy of a new theophylline dosage form: Quibron-T.
Topics: Adolescent; Adult; Aged; Asthma; Attitude; Consumer Behavior; Female; Humans; Male; Middle Aged; Phy | 1982 |
The use of theophylline clearance to design an oral aminophylline regimen.
Topics: Administration, Oral; Adult; Aged; Aminophylline; Asthma; Body Weight; Female; Humans; Kinetics; Lun | 1982 |
Transient alteration of theophylline half-life: possible association with Herpes simplex infection.
Topics: Asthma; Child; Half-Life; Humans; Male; Stomatitis, Herpetic; Theophylline | 1982 |
Treatment of children with a single dose a day of sustained release theophylline.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Female; Humans; Male; Theophylline; Time Fac | 1982 |
[The theophylline test. Indications for the effective daily dosage (author's transl)].
Topics: Adolescent; Adult; Asthma; Female; Half-Life; Humans; Male; Middle Aged; Theophylline | 1982 |
Sustained-release theophylline for treatment of asthma in preschool children.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Male; Respiratory Func | 1982 |
Pulmonary lavage in a patient in status asthmaticus receiving mechanical ventilation: a case report.
Topics: Aminophylline; Arrhythmias, Cardiac; Asthma; Female; Humans; Lung; Middle Aged; Respiration, Artific | 1982 |
[Serum theophylline levels in aminophyllin treatment in children].
Topics: Adult; Age Factors; Aminophylline; Asthma; Child; Child, Preschool; Humans; Infant; Middle Aged; The | 1982 |
Physician/patient acceptability and efficacy study of Quibron-T/SR tablets in adult asthmatics.
Topics: Adult; Asthma; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Male; Middle Aged; Pati | 1982 |
Phenytoin-theophylline interaction.
Topics: Asthma; Drug Interactions; Half-Life; Humans; Male; Middle Aged; Phenytoin; Seizures; Theophylline | 1982 |
Theophylline blood levels as a guide to intravenous therapy in children.
Topics: Adolescent; Asthma; Child; Child, Preschool; Humans; Infant; Infusions, Parenteral; Length of Stay; | 1982 |
Management of respiratory problems in the aged.
Topics: Aged; Asthma; Common Cold; Cough; Expectorants; Glucocorticoids; Humans; Lung Diseases, Obstructive; | 1982 |
Separate and combined use of terbutaline and theophylline in asthmatics. Effects related to plasma levels.
Topics: Adult; Aged; Asthma; Dose-Response Relationship, Drug; Drug Interactions; Female; Forced Expiratory | 1982 |
[Theophylline in the treatment of childhood asthma].
Topics: Asthma; Child; Humans; Theophylline; Time Factors | 1982 |
Intravenous maintenance aminophylline dosage in patients with asthma on regular oral theophylline.
Topics: Administration, Oral; Adolescent; Aminophylline; Asthma; Child; Female; Humans; Infusions, Parentera | 1982 |
[The asthma attack - status asthmaticus].
Topics: Acute Disease; Adrenal Cortex Hormones; Anti-Bacterial Agents; Asthma; Humans; Oxygen Inhalation The | 1982 |
Theophylline compliance in adolescent patients with chronic asthma.
Topics: Adolescent; Asthma; Humans; Patient Compliance; Theophylline | 1982 |
Slow-release theophylline for the treatment of chronic asthma.
Topics: Adult; Asthma; Child; Chronic Disease; Delayed-Action Preparations; Humans; Infant; Theophylline | 1982 |
Diagnosis and management of outpatient adult asthma.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Female; Humans; Hypersensitivity; Ma | 1982 |
[The dose-concentration nomogram for intravenous theophylline therapy].
Topics: Aminophylline; Asthma; Humans; Infusions, Parenteral; Theophylline | 1982 |
[Theophylline. A new look at an old drug].
Topics: Asthma; Cardiovascular System; Central Nervous System; Humans; Kinetics; Muscles; Theophylline | 1982 |
[Plasma theophylline level in patients with bronchial asthma treated with novphyllin].
Topics: Adolescent; Adult; Aminophylline; Asthma; Female; Half-Life; Humans; Male; Middle Aged; Theophylline | 1982 |
Pharmacokinetics and dose regimen of oral theophylline in children.
Topics: Administration, Oral; Asthma; Child; Child, Preschool; Drug Administration Schedule; Enema; Humans; | 1982 |
[Adaptation of the oral dosage of theophylline to the asthmatic child. Value of a kinetic test by the intravenous route].
Topics: Administration, Oral; Adolescent; Age Factors; Asthma; Child; Child, Preschool; Delayed-Action Prepa | 1982 |
[Effect of methylprednisolone on serum theophylline levels].
Topics: Asthma; Child; Child, Preschool; Drug Interactions; Female; Humans; Male; Methylprednisolone; Theoph | 1982 |
[Clinical pharmacology of theophylline in the treatment of asthma].
Topics: Adolescent; Adult; Aged; Asthma; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Kinetics; | 1982 |
Theophylline.
Topics: Asthma; Humans; Theophylline | 1982 |
Clinical utilization of serum theophylline concentrations in a university-affiliated hospital.
Topics: Adult; Aged; Asthma; Female; Hospitals, University; Humans; Male; Middle Aged; Theophylline | 1982 |
Components of variability in serum theophylline concentrations during maintenance therapy with a sustained release formulation.
Topics: Administration, Oral; Adult; Asthma; Bronchial Spasm; Delayed-Action Preparations; Female; Forced Ex | 1982 |
[The relationship between plasma theophylline levels and respiratory impedance in asthmatic patients].
Topics: Asthma; Humans; Respiration; Theophylline | 1982 |
Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation.
Topics: Adult; Aging; Asthma; Biological Availability; Child; Delayed-Action Preparations; Dose-Response Rel | 1982 |
Theophylline serum concentration and therapeutic effect in severe acute bronchial obstruction.
Topics: Asthma; Child; Humans; Theophylline | 1982 |
[Serum theophylline levels after oral administration in a group of asthmatic children].
Topics: Administration, Oral; Asthma; Child; Child, Preschool; Female; Humans; Male; Theophylline; Time Fact | 1982 |
Risks of theophylline therapy in asthma.
Topics: Asthma; Child; Humans; Risk; Seizures; Theophylline | 1981 |
Strategies to improve drug compliance in children.
Topics: Asthma; Child; Humans; Patient Compliance; Theophylline | 1981 |
Theophylline: the concept of sustained action.
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Child; Delayed-Action Preparations; Drug Tolerance | 1981 |
Neuropsychological correlates of asthma: brain damage or drug effects?
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Child; Humans; Neurocognitive Disorders; Substance-Rela | 1981 |
Maintenance oral theophylline therapy: suggested schedule in elderly patients.
Topics: Administration, Oral; Aged; Asthma; Chronic Disease; Drug Administration Schedule; Female; Humans; I | 1980 |
Dyphylline aerosol attenuates antigen-induced bronchoconstriction in experimental canine asthma.
Topics: Aerosols; Animals; Antigens; Ascaris; Asthma; Bronchial Diseases; Constriction, Pathologic; Dogs; Dy | 1981 |
Asthma induced by dust from urea-formaldehyde foam insulating material.
Topics: Asthma; Bronchial Provocation Tests; Construction Materials; Dust; Female; Formaldehyde; Humans; Mid | 1981 |
Rectal administration of theophylline in aqueous solution.
Topics: Asthma; Child; Child, Preschool; Female; Half-Life; Humans; Male; Suppositories; Theophylline; Time | 1981 |
Sleeping bradycardia during recovery from childhood status asthmaticus.
Topics: Aminophylline; Asthma; Bradycardia; Child; Electrocardiography; Heart Rate; Humans; Isoetharine; Iso | 1981 |
Chronic cough in children: a manifestation of airway hyperreactivity.
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Child; Chronic Disease; Cough; Female; Humans; Isoprot | 1981 |
Relationship of formulation and dosing interval to fluctuation of serum theophylline concentration in children with chronic asthma.
Topics: Adolescent; Adult; Asthma; Child; Delayed-Action Preparations; Female; Half-Life; Humans; Male; Tabl | 1981 |
Effect of erythromycin on theophylline clearance in asthmatic children.
Topics: Adolescent; Asthma; Erythromycin; Female; Humans; Male; Metabolic Clearance Rate; Theophylline | 1981 |
Salivary and urine theophylline levels in management of childhood asthma.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Humans; Saliva; Theophylline | 1981 |
[Theophylline in childhood asthma. Pharmacokinetic and clinical study (author's transl)].
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Half-Life; Humans; Infant; Kinetics; Male; Theo | 1981 |
[Individualization of the dosage of oral theophylline with regular increase method and serum level control in 55 asthmatic children (author's transl)].
Topics: Administration, Oral; Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Infant; Male; The | 1981 |
[Therapy of chronic obstructive respiratory syndrome with the new theophylline preparation Afonilum retard].
Topics: Asthma; Bronchitis; Chronic Disease; Delayed-Action Preparations; Female; Humans; Lung Diseases, Obs | 1981 |
Effect of (dl) 3,7-dihydro-1,8-dimethyl-3-(2-methylbutyl)-1H-purine-2,6-dione on exercise-induced bronchospasm.
Topics: Adult; Asthma; Bronchial Spasm; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Physica | 1981 |
Clinical theophylline pharmacokinetic assessment: a valuable tool.
Topics: Adolescent; Asthma; Humans; Male; Theophylline | 1981 |
Sustained-release theophylline for childhood asthma: evidence for circadian variation of theophylline pharmacokinetics.
Topics: Adolescent; Asthma; Child; Circadian Rhythm; Delayed-Action Preparations; Female; Humans; Kinetics; | 1981 |
Influence of gender on theophylline dosage requirements in children with chronic asthma.
Topics: Adolescent; Asthma; Body Weight; Child; Child, Preschool; Chronic Disease; Female; Humans; Male; Met | 1981 |
Which oral theophylline preparation in asthma?
Topics: Asthma; Humans; Theophylline | 1981 |
Use of theophylline in bronchial asthma.
Topics: Asthma; Delayed-Action Preparations; Humans; Theophylline | 1981 |
A comparison of the pharmacokinetics of theophylline in asthmatic children in the acute episode and in remission.
Topics: Acute Disease; Aminophylline; Asthma; Child; Female; Half-Life; Humans; Kinetics; Male; Theophylline | 1981 |
Salivary and urine theophylline levels in management of childhood asthma.
Topics: Asthma; Child; Humans; Saliva; Theophylline | 1981 |
Sustained-release theophylline.
Topics: Asthma; Delayed-Action Preparations; Humans; Theophylline | 1981 |
[Comparison of bronchodilator effects of salbutamol and theophylline (author's transl)].
Topics: Aerosols; Albuterol; Asthma; Bronchodilator Agents; Female; Humans; Injections, Intravenous; Male; M | 1981 |
The use of albuterol for the prevention of exercise-induced bronchospasm.
Topics: Aerosols; Albuterol; Asthma; Asthma, Exercise-Induced; Atropine; Child; Humans; Isoproterenol; Theop | 1981 |
Therapeutic rounds at the Milton S. Hershey Medical Center.
Topics: Adolescent; Asthma; Cimetidine; Female; Guanidines; Headache; Humans; Nausea; Theophylline | 1981 |
Influence of dietary protein and carbohydrate on oxidative biotransformation of drugs in normal adults and children with asthma.
Topics: Adolescent; Adult; Antipyrine; Asthma; Child; Dietary Carbohydrates; Dietary Proteins; Female; Human | 1981 |
Reproterol and the muscle of the trachea and bronchi: in vitro and in vivo comparative studies with various drugs used in the treatment of asthma.
Topics: Animals; Asthma; Atropine; Bronchi; Bronchodilator Agents; Cattle; Dose-Response Relationship, Drug; | 1981 |
Evaluation of a new sustained-release theophylline tablet for children.
Topics: Adolescent; Adult; Asthma; Biological Availability; Child; Delayed-Action Preparations; Drug Evaluat | 1981 |
Efficacy of theophylline and its N-7-substituted derivatives in experimentally induced bronchial asthma in the guinea-pig.
Topics: Aminophylline; Animals; Asthma; Dyphylline; Female; Guinea Pigs; In Vitro Techniques; Theophylline; | 1981 |
Evaluation of two methods for estimating theophylline clearance prior to achieving steady state.
Topics: Aminophylline; Asthma; Evaluation Studies as Topic; Half-Life; Humans; Lung Diseases, Obstructive; M | 1981 |
[The clinical effect of sustained-release theophylline (Theo-Dur) for asthmatic children and serum theophylline level (author's transl)].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Evaluation; Female; H | 1981 |
[Evaluation of Euphylline-retard based on the measurement of theophylline concentration in the blood serum and spirometric parameters].
Topics: Adult; Aged; Aminophylline; Asthma; Bronchitis; Delayed-Action Preparations; Drug Evaluation; Female | 1981 |
Enprofylline, a principally new antiasthmatic xanthine.
Topics: Animals; Asthma; Cats; Guinea Pigs; In Vitro Techniques; Male; Mice; Theophylline; Xanthines | 1981 |
Adenosine antagonism, a less desirable characteristic of xanthine asthma drugs?
Topics: Adenosine; Animals; Asthma; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Motor Activity; Mu | 1981 |
[Slow-release theophylline in childhood asthma].
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Female; Humans; Male; Theophylline | 1981 |
[Long-term treatment with theophylline].
Topics: Airway Obstruction; Animals; Asthma; Bronchi; Bronchitis; Humans; Kinetics; Rats; Self Administratio | 1981 |
Effect of theophylline and terbutaline on immediate skin tests.
Topics: Administration, Oral; Asthma; Humans; Hypersensitivity, Immediate; Skin Tests; Surveys and Questionn | 1980 |
The management of acute severe asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Asthma; Bed Rest; Child; Fluid Therapy; Humans; Oxyge | 1980 |
Theophylline therapy during pregnancy.
Topics: Asthma; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Theophylline | 1980 |
Theophylline preparations in the treatment of asthma in children.
Topics: Asthma; Child; Child, Preschool; Humans; Theophylline | 1980 |
Obstructive airway disease: rational therapy with theophylline agents.
Topics: Administration, Oral; Aged; Airway Obstruction; Arrhythmias, Cardiac; Asthma; Biotransformation; Fem | 1980 |
Use of inhaled beclomethasone dipropionate and optimized theophylline doses in asthmatic children at Camp Bronco Junction, 1977-1978.
Topics: Administration, Intranasal; Adolescent; Asthma; Beclomethasone; Child; Dose-Response Relationship, D | 1980 |
[Effect of theophylline-ethylenediamine in obstructive lung disease (author's transl)].
Topics: Adolescent; Adult; Aged; Airway Resistance; Asthma; Blood Pressure; Bronchitis; Female; Humans; Lung | 1980 |
Comparison of two dosage schedules of sustained release theophylline in pediatric patients.
Topics: Administration, Oral; Adolescent; Asthma; Child; Forced Expiratory Volume; Humans; Maximal Midexpira | 1980 |
Methylphenidate, neuroleptics and dyskinesia-dystonia.
Topics: Asthma; Child, Preschool; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Dystonia; Humans; Hyp | 1980 |
Utilization of intravenous dihydroxypropyl theophylline (dyphylline) in an aminophylline-sensitive patient, and its pharmacokinetic comparison with theophylline.
Topics: Adult; Aminophylline; Asthma; Dyphylline; Female; Humans; Injections, Intravenous; Kinetics; Theophy | 1980 |
Status asthmaticus.
Topics: Asthma; Child; Humans; Methylprednisolone; Theophylline | 1980 |
[Problems of indication and execution of long-term steroid therapy in advanced disabling bronchial asthma].
Topics: Adrenal Cortex Hormones; Albuterol; Altitude; Asthma; Beclomethasone; Humans; Prednisone; Respirator | 1980 |
Intravenous theophylline therapy in asthma: a clinical update.
Topics: Adenosine Monophosphate; Age Factors; Asthma; Diet; Drug Interactions; Humans; Injections, Intraveno | 1980 |
Salivary theophylline estimation in the management of asthma in children.
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Administration Schedu | 1980 |
[Long-term therapy with a peroral effective theophyllin compound (author's transl)].
Topics: Adult; Aged; Asthma; Bronchitis; Drug Tolerance; Emphysema; Female; Humans; Lung Diseases, Obstructi | 1980 |
Asthma and depression.
Topics: Adolescent; Asthma; Beclomethasone; Child; Depression; Humans; Male; Prednisone; Theophylline | 1980 |
Intravenous administration of aminophylline in asthmatic children taking theophylline orally.
Topics: Administration, Oral; Adolescent; Adult; Aminophylline; Asthma; Child; Child, Preschool; Drug Therap | 1980 |
Efficacy of a 12-hour sustained-release preparation in maintaining therapeutic serum theophylline levels in asthmatic children.
Topics: Adolescent; Asthma; Biological Availability; Child; Delayed-Action Preparations; Female; Humans; Mal | 1980 |
Clinical pharmacology of theophylline.
Topics: Adult; Asthma; Humans; Smoking; Theophylline | 1980 |
Pirbuterol vs. hydroxyzine vs. theophylline vs. placebo in the treatment of bronchial asthma.
Topics: Adolescent; Adult; Asthma; Blood Pressure; Double-Blind Method; Ethanolamines; Female; Forced Expira | 1980 |
Abnormal absorption of a sustained-release theophylline preparation.
Topics: Absorption; Asthma; Child; Chronic Disease; Delayed-Action Preparations; Humans; Kinetics; Male; The | 1980 |
Kinetics of theophylline transfer to breast milk.
Topics: Adult; Aminophylline; Asthma; Female; Humans; Kinetics; Milk, Human; Models, Biological; Theophyllin | 1980 |
Treatment of acute asthmatic attacks in a holding unit of a pediatric emergency room.
Topics: Acute Disease; Administration, Intranasal; Adolescent; Adult; Aminophylline; Asthma; Child; Child, P | 1980 |
Cardiac dysrhythmias during the treatment of acute asthma. A comparison of two treatment regimens by a double blind protocol.
Topics: Acute Disease; Adolescent; Adult; Aminophylline; Arrhythmias, Cardiac; Asthma; Double-Blind Method; | 1980 |
A hand-held calculator program for individualized dosage adjustment of intravenous theophylline in acute asthma.
Topics: Acute Disease; Asthma; Computers; Female; Humans; Injections, Intravenous; Male; Models, Biological; | 1980 |
Pharmacokinetics and taste acceptance of an alcohol-free oxtriphylline solution.
Topics: Asthma; Child, Preschool; Choline; Dose-Response Relationship, Drug; Ethanol; Female; Half-Life; Hum | 1980 |
The effect of theophylline on the lower esophageal sphincter pressure.
Topics: Aminophylline; Asthma; Esophagogastric Junction; Female; Humans; Male; Theophylline | 1980 |
Dose-dependent kinetics for theophylline: observations among ambulatory asthmatic children.
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Chronic Disease; Dose-Response Relationship, Dru | 1980 |
Theophylline and depression.
Topics: Adult; Asthma; Child; Depression; Female; Humans; Theophylline | 1980 |
Simultaneous determination of dyphylline and theophylline in human plasma by high-performance liquid chromatography.
Topics: Asthma; Caffeine; Chromatography, High Pressure Liquid; Dyphylline; Humans; Reference Values; Theobr | 1980 |
Theophylline disposition in infancy.
Topics: Asthma; Delayed-Action Preparations; Female; Half-Life; Humans; Infant; Kinetics; Male; Theophylline | 1981 |
[The effect of aminophylline (Euphyllin) on the mechanics of breathing and the gaseous exchange in persons with bronchial asthma (author's transl)].
Topics: Adult; Asthma; Drug Combinations; Ethylenediamines; Female; Humans; Injections, Intravenous; Middle | 1980 |
Monitoring children on sustained-release therapy by salivary theophylline levels.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Female; Humans; Male; Saliva; Theophylline | 1981 |
Preventive therapy for asthma in children; a 9-year experience in eastern Finland.
Topics: Anti-Asthmatic Agents; Asthma; Beclomethasone; Bronchodilator Agents; Budesonide; Child; Child, Pres | 1995 |
Effects of various drugs (staurosporine, herbimycin A, ketotifen, theophylline, FK506 and cyclosporin A) on eosinophil viability.
Topics: Alkaloids; Asthma; Benzoquinones; Cell Survival; Cyclosporine; Eosinophils; Humans; Ketotifen; Lacta | 1994 |
Theophylline--down but not yet out.
Topics: Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Humans; Theophylline | 1995 |
Management of childhood and adolescent asthma. 1994 consensus. South African Childhood Asthma Working Group.
Topics: Adolescent; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Child; Cromolyn Sodium; Humans; | 1994 |
'Dose dumping' and sustained-release theophylline.
Topics: Asthma; Bronchodilator Agents; Delayed-Action Preparations; Dietary Fats; Fasting; Food-Drug Interac | 1995 |
Theophylline pharmacokinetics in Thai children.
Topics: Absorption; Administration, Oral; Adolescent; Aminophylline; Asthma; Biological Availability; Child; | 1994 |
[Evaluation of the impact of a care program for asthmatic children on the quality of anti-asthma drug prescriptions].
Topics: Administration, Inhalation; Administration, Oral; Administration, Rectal; Adolescent; Age Factors; A | 1995 |
Differential effects of anti-asthmatic drugs on arachidonic acid and platelet-activating factor.
Topics: Albuterol; Aminophylline; Arachidonic Acid; Asthma; Blood Platelets; Bronchodilator Agents; Humans; | 1994 |
[The clinical efficacy and characteristics of the effect of prolonged-action theophyllines on the external respiratory function and hemodynamics of bronchial asthma patients].
Topics: Adolescent; Adult; Aged; Asthma; Chronic Disease; Delayed-Action Preparations; Drug Evaluation; Fema | 1995 |
Effect of the lipoxygenase inhibitor N-hydroxy-N-(6-methoxy-3,4-dihydro-2-naphthylmethyl)urea on bronchoconstriction and lung vascular permeability in anaphylactic guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Capillary Permeability; Guinea Pigs; In Vitro Tec | 1995 |
Asthma and airway inflammation: potential anti-inflammatory activities of phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Airway Resistan | 1995 |
Left ventricular function in asthmatic children chronically treated with theophylline evaluated by exercise Doppler echocardiography.
Topics: Adolescent; Asthma; Blood Flow Velocity; Child; Echocardiography; Echocardiography, Doppler; Exercis | 1994 |
Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Analysis of Variance; Animals; Asth | 1995 |
The position of theophylline in the treatment of asthma and chronic obstructive pulmonary disease.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Animals; Asthma; Bronchodil | 1995 |
Theophylline and phosphodiesterase inhibitors.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Endothelium, Vascu | 1995 |
Drugs for asthma.
Topics: Administration, Topical; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Inflammatory | 1995 |
The clinical implication of theophylline intoxication in the Emergency Department.
Topics: Aged; Analysis of Variance; Arrhythmias, Cardiac; Asthma; Creatine Kinase; Digestive System; Dose-Re | 1994 |
Morbidity, medication and trigger factors in a community sample of adults with asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Air Pollution; | 1995 |
[Status epilepticus in an asthmatic child].
Topics: Asthma; Bronchodilator Agents; Child, Preschool; Drug Therapy, Combination; Humans; Ketotifen; Male; | 1994 |
[Theophylline--at 100 years old into its 4th life].
Topics: Airway Resistance; Asthma; Humans; Immune Tolerance; Respiratory Hypersensitivity; Theophylline | 1994 |
Effects of an acaricide on asthmatic children with house dust mite allergy.
Topics: Administration, Inhalation; Adolescent; Animals; Asthma; Bronchial Provocation Tests; Child; Cromoly | 1994 |
The design of oral sustained-release theophylline dosing after conversion from intravenous to oral therapy.
Topics: Administration, Oral; Adolescent; Aminophylline; Asthma; Bayes Theorem; Child; Child, Preschool; Del | 1994 |
Slow-release theophylline in pregnant asthmatics.
Topics: Adolescent; Adult; Asthma; Case-Control Studies; Delayed-Action Preparations; Female; Humans; Pregna | 1995 |
Theophylline attenuates circulating vitamin B6 levels in children with asthma.
Topics: Adolescent; Asthma; Child; Cromolyn Sodium; Delayed-Action Preparations; Female; Humans; Male; Pyrid | 1994 |
Stuttering induced by theophylline.
Topics: Asthma; Child; Child, Preschool; Female; Humans; Male; Retrospective Studies; Stuttering; Theophylli | 1994 |
[Bronchial asthma in childhood. Part 2: Prevention and step-wise plan for drug therapy].
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Anti-Inflammatory Agents | 1993 |
Theophylline: should we discard an old friend?
Topics: Acute Disease; Asthma; Humans; Theophylline | 1994 |
What role for theophylline?
Topics: Adrenergic beta-Agonists; Asthma; Bronchial Spasm; Humans; Lung Diseases, Obstructive; Respiratory M | 1994 |
Changing strategies in the management of asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Humans; Leukotriene Antagonists; Theophyl | 1994 |
Comparison of parameters of in vitro lymphocyte beta 2-adrenoceptor function in normal and asthmatic subjects.
Topics: Adrenergic beta-Agonists; Adult; Asthma; Cyclic AMP; Female; Forced Expiratory Volume; Humans; In Vi | 1993 |
Theophylline.
Topics: Asthma; Hospitalization; Humans; Lung Diseases, Obstructive; Theophylline | 1994 |
Theophylline.
Topics: Asthma; Humans; Theophylline | 1994 |
Assessment of an ambulatory care asthma program.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Ambulatory Care; Asthma; Bronchodilator | 1994 |
Compliance with pharmacologic prophylaxis and therapy in bronchial asthma.
Topics: Administration, Inhalation; Adolescent; Albuterol; Asthma; Beclomethasone; Bronchodilator Agents; Ch | 1994 |
Prediction of steady-state serum theophylline concentration in children by first-order and zero-order absorption models.
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Fluorescence Polarization; Humans; Intestinal A | 1994 |
Effect of theophylline on serum uric acid levels in children with asthma.
Topics: Adolescent; Asthma; Child; Female; Humans; Male; Substance Withdrawal Syndrome; Theophylline; Uric A | 1994 |
[Chronic drug treatment of asthma].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Drug Therapy, C | 1994 |
Prescription of bronchodilator drugs by primary health care physicians in asthma.
Topics: Adrenergic Agents; Asthma; Bronchodilator Agents; Drug Utilization; Family Practice; Glucocorticoids | 1994 |
Cytokine studies in allergy and asthma.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Asthma; Cytokines; Humans; Hypersensitivity | 1994 |
Comparison of patients' compliance with prescribed oral and inhaled asthma medications.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adult; Asthma | 1994 |
Prescribed drug therapy and near-fatal asthma attacks.
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Case-Control Studies; Female; Fenot | 1994 |
Pharmacological modulation of immediate and late airway response and leukocyte infiltration in the guinea pig.
Topics: Acetylcholine; Airway Resistance; Animals; Antibodies; Asthma; Benzoquinones; Bronchoalveolar Lavage | 1994 |
[The usefulness of theophylline in the treatment of moderate-severe asthma].
Topics: Adult; Asthma; Chronic Disease; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Male; | 1994 |
[The usefulness of the bayesian method for the prediction of plasma theophylline levels in asthmatic children during RTC therapy by the sustained preparation of theophylline].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Monitoring; Female; H | 1994 |
Asthma medication in children-1991.
Topics: Administration, Topical; Adolescent; Age Factors; Anti-Inflammatory Agents; Asthma; Bronchodilator A | 1994 |
Pulmonary function, activated T cells, peripheral blood eosinophilia, and serum activity for eosinophil survival in vitro: a longitudinal study in bronchial asthma.
Topics: Adolescent; Adult; Aged; Asthma; Blood; Cell Survival; Cells, Cultured; Eosinophilia; Eosinophils; F | 1994 |
[Preliminary evaluation of efficacy for the preparation DNCG-compositum in treatment of atopic bronchial asthma in children].
Topics: Administration, Inhalation; Adolescent; Asthma; Bronchodilator Agents; Child; Cromolyn Sodium; Drug | 1994 |
Theophylline: when should it be used?
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Child; Cromolyn Sodium; Epinephrin | 1993 |
Theophylline toxic effects from an over-the-counter asthma medication.
Topics: Adult; Asthma; Female; Humans; Nonprescription Drugs; Self Medication; Theophylline; Vomiting | 1993 |
Use of theophylline in childhood and adolescent asthma. Addendum to the 1991 consensus statement. South African Childhood Asthma Working Group (SACAWG).
Topics: Acute Disease; Adolescent; Asthma; Child; Humans; Theophylline | 1993 |
Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs.
Topics: Albuterol; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoa | 1993 |
[Risk factors for gastroesophageal reflux in chronic asthma].
Topics: Adolescent; Adult; Aged; Asthma; Chronic Disease; Female; Gastric Acidity Determination; Gastroesoph | 1993 |
[Successful combination therapy in bronchial asthma. Anti-obstructive and anti-inflammatory treatment].
Topics: Administration, Inhalation; Administration, Oral; Asthma; Beclomethasone; Drug Therapy, Combination; | 1994 |
[Effect of intravenous infusions of theophylline on cardiac arrhythmias and activity of creatinine kinase CK-MB in patients with airway obstruction].
Topics: Adult; Aged; Airway Obstruction; Arrhythmias, Cardiac; Asthma; Bronchitis; Creatine Kinase; Female; | 1993 |
Drug interactions with anti-asthma medication.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Drug Interactions; Humans; Sympathomimetics; | 1994 |
[Decreased theophylline clearance in children with acute asthma with concurrent febrile respiratory infection].
Topics: Acute Disease; Adolescent; Aminophylline; Asthma; Child; Child, Preschool; Fever; Humans; Infant; In | 1994 |
Risk factors for readmission to hospital for asthma in childhood.
Topics: Age Distribution; Asthma; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; | 1994 |
Age-dependent changes of renal excretion of theophylline in asthmatic children.
Topics: Administration, Oral; Aging; Asthma; Bronchitis; Child, Preschool; Chronic Disease; Delayed-Action P | 1994 |
Evaluation of three theophylline dosing equations for use in infants up to one year of age.
Topics: Apnea; Asthma; Bradycardia; Dose-Response Relationship, Drug; Female; Humans; Infant; Infant, Newbor | 1993 |
Intravenous theophylline-induced excretion of calcium, magnesium and sodium in patients with recurrent asthmatic attacks.
Topics: Administration, Oral; Adult; Aged; Albuterol; Asthma; Calcium; Female; Humans; Infusions, Intravenou | 1994 |
[Bronchial asthma: use of combination therapy. Anti-obstructive and anti-inflammatory treatment--result of treatment].
Topics: Adult; Asthma; Beclomethasone; Drug Therapy, Combination; Female; Humans; Rhinitis, Allergic, Perenn | 1994 |
[The pharmacodynamics of theophylline (euphylline)].
Topics: Adult; Aged; Aminophylline; Asthma; Bronchitis; Chronic Disease; Female; Hemodynamics; Humans; Injec | 1993 |
Audit of theophylline plasma level monitoring in a pediatric hospital.
Topics: Asthma; Child; Child, Preschool; Drug Monitoring; Fluorescence Polarization Immunoassay; Hospitals, | 1993 |
Hemlock or healer? The mercurial reputation of theophylline.
Topics: Asthma; Humans; Theophylline | 1993 |
A study of self poisoning with oral salbutamol--laboratory and clinical features.
Topics: Adolescent; Adult; Aged; Albuterol; Asthma; Child, Preschool; Female; Humans; Male; Middle Aged; Pot | 1993 |
Variations in the use of medication for the treatment of childhood asthma in the Michigan Medicaid population, 1980 to 1986.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Black or African American; Child; Child, Preschool; Cro | 1993 |
Relapse following emergency treatment for acute asthma: can it be predicted or prevented?
Topics: Acute Disease; Adolescent; Asthma; Canada; Child; Child, Preschool; Emergencies; Emergency Service, | 1993 |
Excessive dobutamine-induced tachycardia in the asthmatic cardiac patient: possible potentiation by theophylline therapy.
Topics: Aged; Aortic Valve Stenosis; Asthma; Dobutamine; Drug Synergism; Heart Diseases; Humans; Hypertrophy | 1993 |
Electroconvulsive therapy in patients taking theophylline.
Topics: Adult; Aged; Asthma; Bronchitis; Chronic Disease; Comorbidity; Depressive Disorder; Electroconvulsiv | 1993 |
[Effects of theophylline on ventilatory regulation in patients with chronic obstructive pulmonary disease].
Topics: Administration, Oral; Adult; Asthma; Blood Gas Analysis; Emphysema; Humans; Lung Diseases, Obstructi | 1993 |
Clinical problem-solving: too old for what?
Topics: Age Factors; Aged; Aged, 80 and over; Aortic Valve Stenosis; Asthma; Contraindications; Erythromycin | 1993 |
Allergist influence on asthma care.
Topics: Administration, Inhalation; Allergy and Immunology; Asthma; Child; Child, Preschool; Cromolyn Sodium | 1993 |
[Severe theophylline toxicity in a pregnant asthmatic patient].
Topics: Adult; Asthma; Cesarean Section; Female; Humans; Poisoning; Pregnancy; Pregnancy Complications; Theo | 1993 |
[Clinical evaluation of disodium cromoglycate with beta-2-agonist in therapy of patients with atopic bronchial asthma (preliminary study)].
Topics: Administration, Inhalation; Adult; Asthma; Bronchodilator Agents; Cromolyn Sodium; Drug Combinations | 1993 |
Population pharmacokinetics of theophylline. I: Intravenous infusion to children in the acute episode of asthma.
Topics: Acute Disease; Adolescent; Age Factors; Asthma; Blood Chemical Analysis; Blood Gas Analysis; Child; | 1993 |
Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Animals; Asthma; Bronchodilator Agents; Cyclic Nuc | 1993 |
[Compliance of children with bronchial asthma in long-term therapy with theophylline retard preparations].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Long-Term | 1993 |
Advances in the management of childhood asthma.
Topics: Administration, Topical; Anti-Inflammatory Agents; Asthma; Beclomethasone; Child; Cromolyn Sodium; F | 1993 |
Are current pediatric dose recommendations for intravenous theophylline appropriate?
Topics: Adolescent; Age Factors; Analysis of Variance; Asthma; Body Temperature; Child; Child, Preschool; Dr | 1993 |
Association between exposure to environmental tobacco smoke and exacerbations of asthma in children.
Topics: Adolescent; Asthma; Child; Child, Preschool; Cotinine; Environmental Exposure; Female; Forced Expira | 1993 |
[Toxic dermatitis induced by bamifylline. 2 cases].
Topics: Aged; Asthma; Bronchodilator Agents; Dermatitis, Exfoliative; Drug Eruptions; Exanthema; Female; Hum | 1993 |
Treating nocturnal asthma poses challenges.
Topics: Albuterol; Asthma; Circadian Rhythm; Delayed-Action Preparations; Humans; Peak Expiratory Flow Rate; | 1993 |
Day-night variation of airways status in sympathomimetic- and theophylline-treated asthma patients.
Topics: Administration, Inhalation; Adult; Aged; Analysis of Variance; Asthma; Circadian Rhythm; Delayed-Act | 1993 |
[Asthma and pregnancy].
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Female; Humans; Peak Expiratory Flow Rate; P | 1995 |
[Is routine monitoring of theophylline blood levels really effective?].
Topics: Asthma; Bronchodilator Agents; Diagnostic Tests, Routine; Drug Monitoring; Humans; Lung Diseases, Ob | 1995 |
[In vitro induction of apoptosis in chronic lymphoid leukemia B lymphocytes by theophylline: therapeutic applications].
Topics: Aged; Antineoplastic Agents, Alkylating; Apoptosis; Asthma; B-Lymphocytes; Bronchodilator Agents; Ch | 1995 |
Theophylline in asthma--no longer the bad egg in the basket!
Topics: Asthma; Bronchodilator Agents; Humans; Theophylline | 1995 |
Minor symptoms are not predictive of elevated theophylline levels in adults on chronic therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Female; Humans; Male; Middle Aged; Prospective S | 1995 |
Surgical therapy for Wolff-Parkinson-White syndrome in patients with bronchial asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Asthma; Bronchial Spasm; B | 1996 |
The effect of a subnormal vitamin B-6 status on homocysteine metabolism.
Topics: Administration, Oral; Adult; Asthma; Bronchodilator Agents; Cystathionine; Female; Homocysteine; Hum | 1996 |
Anti-inflammatory effects of theophylline: modulation of cytokine production.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cytokine | 1996 |
[Adult onset of asthma and their therapy (discussion)].
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Anti-Allergic Agents; Anti-Inflammatory | 1996 |
Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits.
Topics: Airway Resistance; Alternaria; Animals; Anti-Inflammatory Agents; Antigens, Fungal; Asthma; Bronchia | 1996 |
Application of population pharmacokinetics to the optimization of theophylline therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Bronchodilator Agents; Female; Humans; Male; Met | 1996 |
Avoiding adverse reactions.
Topics: Antacids; Anti-Infective Agents; Asthma; Bronchodilator Agents; Ciprofloxacin; Drug Interactions; Hu | 1996 |
Properties controlling the diffusion and release of water-soluble solutes from poly(ethylene oxide) hydrogels: 3. Device geometry.
Topics: Aminophylline; Asthma; Cross-Linking Reagents; Diffusion; Drug Delivery Systems; Gels; Half-Life; Ma | 1996 |
Properties controlling the diffusion and release of water-soluble solutes from poly(ethylene oxide) hydrogels. 4. Extended constant rate release from partly-coated spheres.
Topics: Aminophylline; Asthma; Delayed-Action Preparations; Diffusion; Drug Delivery Systems; Gels; Hydrogen | 1996 |
[Inhibition of growth hormone secretion by theophylline in asthmatic children].
Topics: Adolescent; Asthma; Bronchodilator Agents; Child; Child, Preschool; Dose-Response Relationship, Drug | 1996 |
The role of pharmacology and forensics in the death of an asthmatic.
Topics: Administration, Inhalation; Adult; Albuterol; Asthma; Fatal Outcome; Heroin; Humans; Lung; Male; Mor | 1995 |
Theophylline in acute asthma.
Topics: Acute Disease; Asthma; Bronchodilator Agents; Child; Clinical Trials as Topic; Humans; Theophylline | 1996 |
[Serum concentrations of the pyridoxal and pyridoxal-5'-phosphate in children during sustained-release theophylline therapy].
Topics: Asthma; Bronchodilator Agents; Child; Delayed-Action Preparations; Female; Humans; Male; Pyridoxal; | 1996 |
Proceedings of the Theophylline Forum. Stockholm, 25 June 1994.
Topics: Asthma; Bronchodilator Agents; Humans; Lung Diseases, Obstructive; Theophylline | 1996 |
Theophylline at therapeutic concentration suppresses PAF-induced upregulation of Mac-1 on human eosinophils.
Topics: Asthma; Eosinophils; Humans; Macrophage-1 Antigen; Platelet Activating Factor; Rhinitis, Allergic, S | 1996 |
Effect of long-term administration of theophylline on serum immunoglobulin E level in asthmatic children--preliminary study.
Topics: Adolescent; Asthma; Beclomethasone; Child; Child, Preschool; Cromolyn Sodium; Dose-Response Relation | 1996 |
[Practicability, effectiveness and tolerance of a standardized prepared theophylline infusion].
Topics: Adult; Aged; Asthma; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forced | 1996 |
Bronchodilators and acute cardiac death.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Cerebrovascular Disorder | 1996 |
Perioperative management for childhood asthma.
Topics: Adrenergic beta-Agonists; Asthma; Bronchial Spasm; Bronchodilator Agents; Child; Child, Preschool; H | 1996 |
[Therapeutic management of asthma: what is safe? What is new? What is being done incorrectly].
Topics: Asthma; Bronchodilator Agents; Delayed-Action Preparations; Humans; Theophylline; Vital Capacity | 1996 |
Profile of children requiring emergency treatment for asthma.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asth | 1997 |
Zileuton for asthma.
Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Dr | 1997 |
Inhaled steroids and the risk of hospitalization for asthma.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Anti | 1997 |
Effects of Y-24180, a long-acting and potent antagonist to platelet-activating factor, on immediate asthmatic response in guinea pigs.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Azepines; Benzoquinones; Bronchodilator Agents; Chromones; D | 1997 |
[Theophylline in therapy of bronchial asthma--is a reevaluation necessary?].
Topics: Airway Resistance; Animals; Asthma; Bronchodilator Agents; Drug Therapy, Combination; Humans; Theoph | 1996 |
[Comparison of serum concentrations of once and twice daily administration of ultra-retard theophylline in school children with bronchial asthma].
Topics: Adolescent; Asthma; Bronchodilator Agents; Child; Delayed-Action Preparations; Dose-Response Relatio | 1996 |
Allergen challenge of passively sensitized human bronchi alters M2 and beta2 receptor function.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Allergens; Animals; Asthma; Bronchi; Bronchial Hyp | 1997 |
Adjusted odds ratios for case-control studies with missing confounder data in controls.
Topics: Asthma; Bronchodilator Agents; Case-Control Studies; Confounding Factors, Epidemiologic; Death, Sudd | 1997 |
Suppressive effects of Y-24180, a receptor antagonist to platelet activating factor (PAF), on antigen-induced asthmatic responses in guinea pigs.
Topics: Administration, Oral; Aerosols; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Asthma; Azepin | 1997 |
[Acute theophylline intoxication as differential diagnosis of pneumothorax in an asthma patient].
Topics: Administration, Oral; Asthma; Bronchodilator Agents; Diagnosis, Differential; Dose-Response Relation | 1997 |
Oral vs i.v. steroids for asthma.
Topics: Administration, Oral; Adolescent; Adult; Albuterol; Anti-Inflammatory Agents, Non-Steroidal; Asthma; | 1997 |
Roxithromycin attenuates acid-induced cough and water-induced bronchoconstriction in children with asthma.
Topics: Acetic Acid; Adolescent; Anti-Bacterial Agents; Asthma; Bronchoconstriction; Child; Cough; Female; F | 1997 |
Inhibitory effects of theophylline and procaterol on eosinophil function.
Topics: Asthma; Bronchodilator Agents; CD11 Antigens; CD18 Antigens; Cell Adhesion Molecules; Cell Degranula | 1997 |
[The efficacy of inhaled glucocorticosteroids in different dosage regimens and in combination with theophylline preparations in bronchial asthma patients].
Topics: Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Drug Evaluation; Drug Therapy, Com | 1997 |
Drug use and pulmonary death rates in increasingly symptomatic asthma patients in the UK.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Albuterol; Asthma; Bronchodilator Agents; Case-Control | 1997 |
Asthma guidelines.
Topics: Aminophylline; Asthma; Bronchodilator Agents; Contraindications; Emergencies; Humans; Theophylline | 1997 |
[Therapeutic and toxic theophylline levels in asthma attacks--is there a need for additional theophylline?].
Topics: Adult; Asthma; Bronchodilator Agents; Delayed-Action Preparations; Dose-Response Relationship, Drug; | 1997 |
Disposition of intravenous theophylline in asthmatic children: Bayesian approach vs direct pharmacokinetic calculations.
Topics: Asthma; Bayes Theorem; Bronchodilator Agents; Child; Child, Preschool; Dose-Response Relationship, D | 1997 |
Serum theophylline and menstrual asthma attack.
Topics: Adolescent; Asthma; Bronchodilator Agents; Female; Humans; Luteal Phase; Theophylline | 1997 |
Maintaining theophylline compliance/adherence in severely asthmatic children: the role of psychologic functioning of the child and family.
Topics: Adolescent; Asthma; Child; Child Behavior; Child, Preschool; Family Relations; Female; Humans; Male; | 1997 |
Asthma disease management.
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Budesonide; Drug Therapy, Combination; Etha | 1997 |
Heart rate variability during 24 hours in asthmatic children.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Anti-Allergic Agents; Asthma; Case-Control Studies; | 1997 |
Gout due to xanthine derivatives.
Topics: Allopurinol; Aminophylline; Asthma; Benzbromarone; Bronchodilator Agents; Drug Therapy, Combination; | 1997 |
[Problems in the treatment of bronchial asthma].
Topics: Adrenergic beta-Agonists; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Glucocorticoids; | 1996 |
Apparent decrease in population clearance of theophylline: implications for dosage.
Topics: Adolescent; Age Factors; Asthma; Body Weight; Bronchodilator Agents; Child; Child, Preschool; Chroni | 1997 |
[Factors responsible for the course and long-term outcomes of bronchial asthma: chemotherapy].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Asthma; Beclomethasone; Bronchodilator Agents; Fem | 1997 |
[Thoracotomy for patients with bronchial asthma].
Topics: Adult; Aminophylline; Anesthetics, Inhalation; Asthma; Blister; Bronchodilator Agents; Female; Human | 1994 |
Theophylline suppresses the release of interleukin-4 by peripheral blood mononuclear cells.
Topics: Adult; Antigens, Dermatophagoides; Asthma; Bronchodilator Agents; Cells, Cultured; Cyclic AMP; Femal | 1998 |
[Selected aspects of theophylline antiinflammatory action on the respiratory tract].
Topics: Animals; Anti-Inflammatory Agents; Asthma; Cytokines; Humans; Respiratory System; Theophylline | 1997 |
Medications used by children with asthma living in the inner city.
Topics: Adrenergic beta-Agonists; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Baltimore; Bronch | 1998 |
Activation of platelets in bronchial asthma.
Topics: Administration, Oral; Adult; Aged; Asthma; Blood Platelets; Bronchodilator Agents; Calcium; Case-Con | 1998 |
Asthma management: the challenge of equivalence.
Topics: Administration, Inhalation; Anti-Asthmatic Agents; Area Under Curve; Asthma; Chlorofluorocarbons; Co | 1998 |
Mite antigen-induced IL-4 and IL-13 production by basophils derived from atopic asthma patients.
Topics: Administration, Topical; Adult; Animals; Anti-Inflammatory Agents; Antigens; Antigens, Dermatophagoi | 1998 |
Theophylline inhibits the production of nitric oxide by peripheral blood mononuclear cells from patients with asthma.
Topics: Adult; Anti-Inflammatory Agents; Asthma; Female; Humans; Leukocytes, Mononuclear; Male; Middle Aged; | 1998 |
Effects of theophylline on lymphocyte phosphodiesterase activity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Age Factors; Aminophylline; Asthma; Bronchodilator Agent | 1998 |
[Understanding and therapy of childhood asthma. Rome, 11-13 May].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Age Factors; Asthma; Child; Child, Preschool; Fem | 1998 |
Differences in the anti-inflammatory effects of theophylline and pentoxifylline: important for the development of asthma therapy?
Topics: Adult; Aged; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Blood Cells; Ce | 1998 |
Risk of emergency care, hospitalization, and ICU stays for acute asthma among recipients of salmeterol.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Age Factors; Albuterol; Anti-Asthmatic Agents; Asthma; | 1998 |
Glucocorticoid receptors in bronchial epithelial cells in asthma.
Topics: Administration, Oral; Adult; Aged; Albuterol; Anti-Inflammatory Agents; Asthma; Biopsy; Bronchi; Bro | 1998 |
[Theophylline and inhaled n corticosteroids in asthma: a reliable combination].
Topics: Administration, Inhalation; Asthma; Beclomethasone; Budesonide; Dose-Response Relationship, Drug; Dr | 1998 |
Inverse association between sarcoidosis and atopic asthma.
Topics: Acute Disease; Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Beclomethasone; Fol | 1998 |
Prehospital treatment of acute asthma in a rural state.
Topics: Acute Disease; Adrenergic beta-Agonists; Albuterol; Asthma; Emergency Medical Technicians; Emergency | 1998 |
Decrease in emergency room or urgent care visits due to management of bronchial asthma inpatients and outpatients with pharmaceutical services.
Topics: Algorithms; Asthma; Bronchodilator Agents; Case-Control Studies; Drug Costs; Emergency Service, Hosp | 1998 |
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients.
Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Th | 1999 |
Drugs for asthma.
Topics: Acetates; Administration, Inhalation; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adr | 1999 |
Nonconvulsive status epilepticus in theophylline toxicity.
Topics: Asthma; Bronchodilator Agents; Electroencephalography; Humans; Male; Middle Aged; Status Epilepticus | 1999 |
Inhaled corticosteroid therapy in asthma: a balancing act.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Albuterol; Androstadi | 1999 |
Comparative effects of a fixed combination of reproterol hydrochloride and disodium cromoglycate with each agent alone on antigen-induced airway responses in sheep.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Aerosols; Airway Resistance; Animals; Anti-All | 1998 |
Development and clinical application of high performance liquid chromatography for the simultaneous determination of plasma levels of theophylline and its metabolites without interference from caffeine.
Topics: Adolescent; Adult; Aged; Asthma; Caffeine; Child; Chromatography, High Pressure Liquid; Female; Fluo | 1999 |
First treatment with inhaled corticosteroids and the prevention of admissions to hospital for asthma.
Topics: Administration, Inhalation; Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; As | 1998 |
Experience of an emergency mobile asthma treatment programme.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Albuterol; Ambulances; Asthma; Broncho | 1997 |
Possible theophylline toxicity during anesthesia.
Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; | 1996 |
Pharmacokinetics of theophylline metabolites in 8 Chinese patients.
Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Circadian Rhythm; Humans; Middle Aged; Theophyl | 1998 |
[In focus: Standard combination in asthma therapy. RPR-Press Conversation at the 40th Congress of the German Society for Pneumonology, Bad Reichenhall, 19 March 1999].
Topics: Anti-Allergic Agents; Asthma; Bronchodilator Agents; Drug Combinations; Humans; Ketotifen; Metaprote | 1999 |
[Drug monitoring during the treatment with theophylline preparations of children with bronchial asthma].
Topics: Asthma; Bronchodilator Agents; Child; Dose-Response Relationship, Drug; Drug Monitoring; Humans; The | 1999 |
Options for bronchodilation in children: can we rely on adult data?
Topics: Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Child; Child, Preschool; Cholinergic | 1999 |
[Oral dyskinesias in two infants following use of theophylline during asthma attack].
Topics: Asthma; Bronchodilator Agents; Child, Preschool; Dyskinesia, Drug-Induced; Humans; Infant; Male; Mou | 1999 |
Evaluation of the effect of low-dose oral theophylline therapy on some bone turnover markers and serum prolidase I activity in mild asthmatics.
Topics: Administration, Oral; Adolescent; Adult; Aged; Alkaline Phosphatase; Amino Acids; Asthma; Biomarkers | 1999 |
Enhanced theophylline metabolism in patients with bronchial asthma at age 4 and under.
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Child; Child, Preschool; Chromatography, High Pres | 1999 |
A cost analysis on the pattern of asthma prescribing in the UK.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; C | 1999 |
[Population pharmacokinetic analysis of theophylline: relationship between serum concentrations and clinical effects in therapeutic drug monitoring].
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Biological Availability; B | 1999 |
Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells.
Topics: Adrenergic beta-Agonists; Albuterol; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; CD4-Po | 1999 |
[Effects of theopek and saltos on cardiorespiratory system in bronchial asthma].
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Cardiovascular System; Delayed-Action Preparations | 1999 |
Phosphodiesterase and cyclic adenosine monophosphate-dependent inhibition of T-lymphocyte chemotaxis.
Topics: Albuterol; Asthma; Bucladesine; Chemotaxis, Leukocyte; Colforsin; Cyclic AMP; Humans; Interleukin-8; | 2000 |
[Two cases of Kimura's disease associated with bronchial asthma].
Topics: Adolescent; Adult; Angiolymphoid Hyperplasia with Eosinophilia; Asthma; Beclomethasone; Drug Therapy | 1999 |
The role of adenosine receptors in the action of theophylline on human peripheral blood mononuclear cells from healthy and asthmatic subjects.
Topics: Adenosine Deaminase; Asthma; Cell Division; Humans; In Vitro Techniques; Monocytes; Phosphodiesteras | 2000 |
Synergistic effect of combining theophylline and drugs that potentially elevate serum creatine kinase.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Asthma; Bronchodilator Agents; Creatine Kinase; D | 2000 |
[In defense of aminophylline].
Topics: Aminophylline; Anti-Inflammatory Agents; Asthma; Bronchodilator Agents; Leukocytes; Phosphodiesteras | 1999 |
Drugs for asthma.
Topics: Acetates; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta | 2000 |
Theophylline-induced convulsions in children with epilepsy.
Topics: Asthma; Bronchodilator Agents; Child; Epilepsy; Humans; Infant; Retrospective Studies; Seizures; The | 2000 |
Theophylline induces a reduction in circulating interleukin-4 and interleukin-5 in atopic asthmatics.
Topics: Adult; Asthma; Bronchodilator Agents; Female; Humans; Interleukin-4; Interleukin-5; Male; Theophylli | 1999 |
Association of sympathomimetic drugs with malformations.
Topics: Adult; Aerosols; Animals; Asthma; Drug Combinations; Ephedrine; Female; Humans; Hypnotics and Sedati | 2000 |
Underutilization of controller and rescue medications among older adults with asthma requiring hospital care.
Topics: Administration, Inhalation; Administration, Oral; Administration, Topical; Adrenergic beta-Agonists; | 2000 |
Increased risk for dental caries in asthmatic children.
Topics: Adolescent; Albuterol; Amoxicillin; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; | 1999 |
Optimization and development of a core-in-cup tablet for modulated release of theophylline in simulated gastrointestinal fluids.
Topics: Analysis of Variance; Asthma; Bronchodilator Agents; Chemistry, Pharmaceutical; Delayed-Action Prepa | 2000 |
Guideline for the management of chronic asthma in adults--2000 update. South African Pulmonology Society Adult Asthma Working Group.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asthma; Cholinergic | 2000 |
Circadian rhythm in peak expiratory flow: alteration with nocturnal asthma and theophylline chronotherapy.
Topics: Adult; Aged; Asthma; Bronchodilator Agents; Chronotherapy; Circadian Rhythm; Female; Humans; Male; M | 2000 |
Seasonal variation in heart rate variability in asthmatic children.
Topics: Adolescent; Asthma; Autonomic Nervous System; Bronchodilator Agents; Case-Control Studies; Child; Ch | 2000 |
[Depression of serum pyridoxal levels in theophylline-related seizures].
Topics: Adolescent; Adult; Asthma; Biomarkers; Child; Child, Preschool; Humans; Male; Pyridoxal; Seizures; T | 2000 |
Evidence of oxidative stress in asthma and COPD: potential inhibitory effect of theophylline.
Topics: Aged; Asthma; Female; Forced Expiratory Volume; Humans; Lipid Peroxides; Lung Diseases, Obstructive; | 2000 |
Low-dose inhaled corticosteroids and the prevention of death from asthma.
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Anti-Asthmatic Agents; Asth | 2000 |
[The effect of 6 week treatment with theophylline on spirometric parameters, nonspecific bronchial reactivity and the concentration of soluble interleukin 2 receptor in serum of asthmatic patients].
Topics: Adult; Asthma; Bronchodilator Agents; Female; Humans; Male; Receptors, Interleukin-2; Spirometry; Th | 2000 |
A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Asthma; Case-Control Studies; Guanidines; Humans; | 2000 |
Kinetic alteration of theophylline at therapeutic doses.
Topics: Asthma; Bronchodilator Agents; Female; Heart Rate; Humans; Middle Aged; Theophylline | 2000 |
Practical pharmacotherapy for pediatric asthma.
Topics: Albuterol; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Budesonide; Child; Glucocorticoi | 2000 |
[Early replacement of intravenous aminophylline administration with oral theophylline in treating acute exacerbation of asthma].
Topics: Administration, Oral; Adult; Aminophylline; Asthma; Bronchodilator Agents; Female; Humans; Injection | 2001 |
Effects of glucocorticoids on endogenous and transcellular metabolism of eicosanoids in asthma.
Topics: 5-Lipoxygenase-Activating Proteins; Administration, Inhalation; Administration, Oral; Adrenergic bet | 2001 |
[Reading as a comforting tool].
Topics: Aged; Asthma; Bronchodilator Agents; Diagnosis, Differential; Female; Humans; Poisoning; Theophyllin | 2001 |
Comparative effect of theophylline and aminophylline on theophylline blood concentrations and peripheral blood eosinophils in patients with asthma.
Topics: Adult; Aged; Aged, 80 and over; Aminophylline; Asthma; Bronchodilator Agents; Eosinophils; Female; H | 2001 |
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adolescent; Adult; Allergens; Asthma; CD4-Positive T-Lymphocyte | 2001 |
How pediatricians manage asthma in Thailand.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Bronchodilator Agents; Chronic Disease; Disease Management; | 2001 |
[The role of glucocorticosteroid and theophylline in asthmatic inflammation of murine model and the inhibition in NO production in lung].
Topics: Animals; Anti-Inflammatory Agents; Asthma; Budesonide; Dexamethasone; Lung; Male; Mice; Mice, Inbred | 1998 |
Role of adenosine in asthma.
Topics: Adenosine; Adrenergic beta-Antagonists; Animals; Anti-Asthmatic Agents; Asthma; Bronchoconstriction; | 1996 |
[Chronotherapy of bronchial asthma: circadian rhythms in peak expiratory flow. The report II: Circadian rhythms of peak expiratory flow in asthmatic patients and effect of sustained-release theophylline on various types of the circadian rhythms].
Topics: Adolescent; Adult; Aged; Asthma; Chronotherapy; Circadian Rhythm; Female; Humans; Male; Middle Aged; | 2001 |
[Corrected conclusion in the SBU report: no supplementary effect of theophylline in acute, moderate asthma, but this is not documented in severe life-threatening asthma].
Topics: Adult; Anti-Asthmatic Agents; Asthma; Bronchodilator Agents; Child, Preschool; Drug Information Serv | 2001 |
Effect of passive smoking on theophylline clearance in children.
Topics: Asthma; Bronchodilator Agents; Child; Female; Humans; Male; Metabolic Clearance Rate; Retrospective | 2001 |
Comparative steady-state bioavailability of sustained-release theophylline preparations: Theo-Dur, Uni-Dur and Xanthium.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Biological Availability; Bronchodilator Agents; Cro | 2001 |
Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells.
Topics: Adult; Asthma; Cilostazol; Colforsin; Cyclic AMP; Dexamethasone; Humans; In Vitro Techniques; Interl | 2001 |
Effects of theophylline withdrawal in well-controlled asthmatics treated with inhaled corticosteroid.
Topics: Adult; Aged; Anti-Asthmatic Agents; Asthma; Beclomethasone; Blood Proteins; Bronchodilator Agents; D | 2001 |
Asthma severity and adequacy of management.
Topics: Aminophylline; Asthma; Bronchodilator Agents; Emergencies; Humans; Japan; Severity of Illness Index; | 2002 |
Pulmonary function changes and immunomodulation of Th 2 cytokine expression induced by aminophylline after sensitization and allergen challenge in brown Norway rats.
Topics: Allergens; Aminophylline; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; | 2002 |
Effects of theophylline on airway eosinophils.
Topics: Asthma; Bronchodilator Agents; Eosinophils; Humans; Theophylline | 2002 |
[Official therapy guidelines for the family physician. Your time table in asthma].
Topics: Administration, Topical; Adrenal Cortex Hormones; Androstadienes; Anti-Asthmatic Agents; Anti-Inflam | 2002 |
Effects of theophylline on CD4+ T lymphocyte, interleukin-5, and interferon gamma in induced sputum of asthmatic subjects.
Topics: Adult; Albuterol; Asthma; Bronchodilator Agents; CD4-Positive T-Lymphocytes; Delayed-Action Preparat | 2002 |
[The efficacy of intravenous theophylline injection for treatment of acute exacerbations of bronchial asthma].
Topics: Aged; Asthma; Bronchodilator Agents; Female; Forced Expiratory Volume; Humans; Injections, Intraveno | 2002 |
[Diagnostics and therapy of asthma].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Asthmatic Agents; Asthma; Bronchodilator Age | 2000 |
Pharmacologic therapy of asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic alpha-Antagonists; Aerosols; Aminophylline; Asthm | 1976 |
[Drug therapy of asthma syndrome].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aminophylline; Asthma; Beclomethasone; Child; Cro | 1976 |
Treatment of childhood asthma: application of pathophysiologic principles.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Age Factors; Airway Obstruction; Asth | 1976 |
Management of a child with asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aminophylline; Asthma; Child; Child, | 1977 |
[Bronchodilator therapy of asthma].
Topics: Adrenergic beta-Agonists; Asthma; Atropine; Bronchodilator Agents; Humans; Isoproterenol; Metaproter | 1977 |
Management of the child with recurrent asthma.
Topics: Adolescent; Anti-Bacterial Agents; Asthma; Child; Cromolyn Sodium; Erythromycin; Histamine H1 Antago | 1977 |
The role of the theophyllines in asthma therapy.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Asthma; Dose-Response Relationship, Drug; Drug Co | 1977 |
Current drug therapy of asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Asthma; Humans; Injections, Subcutaneou | 1978 |
Pharmacological aspects of bronchodilators.
Topics: Adrenergic beta-Agonists; Aminophylline; Asthma; Atropine; Bronchi; Bronchodilator Agents; Cyclic AM | 1979 |
Which bronchodilator-and when?
Topics: Adrenergic beta-Agonists; Aerosols; Albuterol; Aminophylline; Asthma; Bronchodilator Agents; Humans; | 1979 |
The current role of oral theophylline derivatives in respiratory medicine. A symposium held in: Montreux, Switzerland, 23rd--24th September 1978: proceedings.
Topics: Asthma; Bronchodilator Agents; Child; Congresses as Topic; Humans; Respiratory Tract Diseases; Switz | 1979 |
Therapeutics in childhood asthma.
Topics: Adrenergic beta-Agonists; Asthma; Child; Cromolyn Sodium; Desensitization, Immunologic; Humans; Para | 1979 |
Drug therapy of bronchial asthma.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; Asthma; Bronchodi | 1979 |
Acute asthma in adults.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Age Factors; Airway Resista | 1979 |
Theophylline in asthma.
Topics: Adrenergic beta-Agonists; Asthma; Drug Therapy, Combination; Emergencies; Humans; Theophylline | 1979 |
[Pediatrics in 1979].
Topics: Abdominal Neoplasms; Age Factors; Asthma; Child; Child, Preschool; Cryptorchidism; Diazepam; Goiter; | 1979 |
Cromoglycate in asthma.
Topics: Asthma; Bronchodilator Agents; Child; Cromolyn Sodium; Drug Evaluation; Humans; Theophylline | 1977 |
Altered theophylline pharmacokinetics during acute respiratory viral illness.
Topics: Acute Disease; Adenoviridae Infections; Adenovirus Infections, Human; Adolescent; Asthma; Child; Chr | 1978 |
Is acephylline a theophylline bronchodilator?
Topics: Asthma; Biological Availability; Bronchodilator Agents; Half-Life; Humans; Piperazines; Theophylline | 1978 |
Inhaled steroid aerosols and alternate-day prednisone.
Topics: Adult; Aerosols; Asthma; Beclomethasone; Child; Cromolyn Sodium; Drug Evaluation; Humans; Prednisone | 1979 |
Drugs for asthma.
Topics: Adrenal Cortex Hormones; Asthma; Beclomethasone; Cromolyn Sodium; Drug Combinations; Drug Therapy, C | 1978 |
An approach to the treatment of asthma.
Topics: Adolescent; Asthma; Beclomethasone; Bronchodilator Agents; Cromolyn Sodium; Female; Humans; Respirat | 1978 |
Modern treatment of bronchial asthma.
Topics: Adrenal Cortex Hormones; Aerosols; Ambulatory Care; Asthma; Bronchodilator Agents; Cromolyn Sodium; | 1978 |
Rational management of bronchial asthma.
Topics: Asthma; Beclomethasone; Cromolyn Sodium; Humans; Metaproterenol; Sympathomimetics; Terbutaline; Theo | 1978 |
The preventive treatment of asthma.
Topics: Aerosols; Asthma; Beclomethasone; Cromolyn Sodium; Humans; Metaproterenol; Sympathomimetics; Terbuta | 1979 |
Diagnosis and management of asthma. Part II: drug therapy in the office.
Topics: Adrenal Cortex Hormones; Asthma; Cromolyn Sodium; Humans; Sympathomimetics; Theophylline | 1979 |
Prophylactic drugs in the management of childhood asthma.
Topics: Adolescent; Aerosols; Asthma; Beclomethasone; Child; Child, Preschool; Cromolyn Sodium; Female; Huma | 1979 |
Drugs other than corticosteroids for the treatment of asthma.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Child; Cromolyn Sodium; Humans; Infant; Parasympathomimetics | 1979 |
Pharmacologic management of pediatric allergic disorders.
Topics: Acute Disease; Adrenal Cortex Hormones; Asthma; Child; Cromolyn Sodium; Dermatitis, Atopic; Expector | 1979 |
Advances in the pharmacologic management of asthma.
Topics: Asthma; Beclomethasone; Bronchodilator Agents; Cromolyn Sodium; Humans; Terbutaline; Theophylline | 1979 |
A simple standardized approach to childhood asthma.
Topics: Albuterol; Asthma; Beclomethasone; Child; Child Health Services; Child, Preschool; Cromolyn Sodium; | 1979 |
New drugs for the treatment of asthma.
Topics: Asthma; Beclomethasone; Bronchodilator Agents; Cromolyn Sodium; Humans; Theophylline | 1979 |
Current concepts in asthma therapy.
Topics: Acute Disease; Administration, Oral; Adrenal Cortex Hormones; Aerosols; Allergens; Asthma; Atropine | 1979 |
Increased adenosine triphosphatase activity in platelets of asthmatic children.
Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenylyl Cyclases; Adolescent; Asthma; Blood Plate | 1975 |
The management of asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Asthma; Child; Cromolyn Sodium; Desensitization, Immunologic | 1976 |
Control of asthma in children.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Allergens; Asthma; Bronchodilator | 1975 |
[Use of bronchodilators].
Topics: Administration, Intranasal; Administration, Oral; Albuterol; Asthma; Bronchial Spasm; Bronchodilator | 1976 |
Effect of salbutamol inhalations of plasma and urinary cyclic adenosine monophosphate levels in asthmatics and non-atopic controls.
Topics: Administration, Oral; Adolescent; Adult; Aerosols; Albuterol; Asthma; Cyclic AMP; Female; Humans; Ma | 1976 |
Comparison of cyclic adenosine monophosphate response of lymphocytes in normal and asthmatic subjects to norepinephrine and salbutamol.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Albuterol; Asthma; Cyclic AMP; Female; Humans; In Vitro | 1977 |
Drug-induced changes of adenylate cyclase activity in cells from asthmatic and nonasthmatic subjects.
Topics: Adenylyl Cyclases; Adult; Asthma; Child; Cyclic AMP; Desensitization, Immunologic; Female; Humans; I | 1977 |
[Plasma cortisol, cyclic adenosine monophosphate and lung function in asthmatic patients].
Topics: Adult; Aged; Albuterol; Asthma; Cosyntropin; Cyclic AMP; Female; Humans; Hydrocortisone; Middle Aged | 1978 |
The pharmacology of bronchodilator drugs: introduction.
Topics: Asthma; Cyclic AMP; Humans; Theophylline | 1979 |
Metabolism of cyclic nucleotides in allergic rhinitis: studies on lymphocytes, granulocytes, and plasma level.
Topics: Adolescent; Adult; Asthma; Child; Cyclic AMP; Cyclic GMP; Granulocytes; Humans; Isoproterenol; Lymph | 1979 |
The asthmatic child: preventing and controlling attacks.
Topics: Asthma; Child; Drainage; Epinephrine; Humans; Isoproterenol; Posture; Theophylline | 1979 |
Questions on serum levels of theophylline.
Topics: Asthma; Child; Child, Preschool; Humans; Kinetics; Theophylline | 1978 |
[General medical concepts for the dental treatment of aging patients].
Topics: Aged; Aging; Asthma; Cardiovascular Diseases; Cortisone; Dietary Carbohydrates; Emergencies; Geriatr | 1977 |
A comparison of oral theophylline and oral salbutamol in exercise-induced asthma.
Topics: Administration, Oral; Adolescent; Adult; Albuterol; Asthma; Child; Female; Humans; Male; Peak Expira | 1977 |
Pharmacokinetics of theophylline in acute asthma.
Topics: Acute Disease; Adolescent; Adult; Aminophylline; Asthma; Child; Child, Preschool; Female; Humans; Ma | 1978 |
Iatrogenic congenital goiter and hypothyroidism with respiratory distress in a newborn.
Topics: Asthma; Congenital Hypothyroidism; Ephedrine; Female; Goiter; Humans; Hypothyroidism; Infant, Newbor | 1978 |
The interaction of erythromycin and theophylline in the asthmatic dental patient.
Topics: Asthma; Cephalosporins; Dental Care; Drug Interactions; Erythromycin; Humans; Penicillins; Theophyll | 1979 |
Bronchodilator effects of oral salbutamol and theophylline-salbutamol combinations in chronic steroid-dependent asthmatics.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Albuterol; Asthma; Chronic Disease; Double-Bli | 1979 |
Subsensitivity of T lymphocytes to sympathomimetic and cholinergic stimulation in bronchial asthma.
Topics: Adult; Asthma; Carbachol; Female; Humans; Isoproterenol; Male; Middle Aged; Parasympathomimetics; Ro | 1978 |
TAO and theophylline.
Topics: Asthma; Drug Interactions; Humans; Theophylline; Troleandomycin | 1978 |
Bronchodilator therapy.
Topics: Animals; Asthma; Bronchial Spasm; Bronchodilator Agents; Child; Humans; Intermittent Positive-Pressu | 1978 |
Comparison of serum theophylline concentrations measured by high pressure liquid chromatography and quantitative enzyme-multiplied immunoassay technique.
Topics: Asthma; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Theophylline | 1979 |
Effects of relaxation training on pulmonary mechanics in children with asthma.
Topics: Adolescent; Arousal; Asthma; Child; Electromyography; Female; Galvanic Skin Response; Heart Rate; Hu | 1979 |
Myths, morbidity, and mortality in asthma.
Topics: Acidosis, Respiratory; Adrenal Cortex Hormones; Asthma; Humans; Intermittent Positive-Pressure Breat | 1979 |
Drugs used in the treatment of asthma.
Topics: Acetylcysteine; Adrenal Cortex Hormones; Aerosols; Asthma; Cromolyn Sodium; Dexamethasone; Drug Comb | 1977 |
Management of asthma. 2. Antiasthmatic drugs.
Topics: Adrenal Cortex Hormones; Asthma; Cromolyn Sodium; Dose-Response Relationship, Drug; Humans; Sympatho | 1977 |
Bronchial asthma: some aspects of pathogenesis and therapy.
Topics: Acute Disease; Aminophylline; Asthma; Beclomethasone; Cromolyn Sodium; Dehydration; Diagnosis, Diffe | 1977 |
Theophylline for treatment of asthma.
Topics: Asthma; Bronchial Spasm; Chronic Disease; Cromolyn Sodium; Drug Combinations; Drug Synergism; Ephedr | 1978 |
Treatment of asthma in children.
Topics: Albuterol; Asthma; Child; Cromolyn Sodium; Humans; Sympathomimetics; Theophylline | 1978 |
Theophylline protein binding in humans.
Topics: Adolescent; Adult; Asthma; Blood Proteins; Child; Child, Preschool; Humans; Infant; Protein Binding; | 1979 |
[Theophylline therapy--foundations and possibilities (author's transl)].
Topics: Adult; Asthma; Biotransformation; Child; Diuresis; Heart; Humans; Infant, Newborn; Muscle, Smooth; T | 1979 |
Serum theophylline levels in asthmatic children after oral administration of a slow-release aminophylline preparation (Phyllocontin Continus tablets).
Topics: Adolescent; Aminophylline; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Humans; The | 1979 |
Gastroesophageal reflux in steroid-dependent asthmatic youths.
Topics: Adolescent; Adrenal Cortex Hormones; Antacids; Asthma; Beclomethasone; Child; Gastroesophageal Reflu | 1979 |
Serum concentrations of theophylline in children following the administration of doses generally recommended: new dosage regimen required.
Topics: Administration, Oral; Adolescent; Aminophylline; Asthma; Body Weight; Child; Child, Preschool; Half- | 1979 |
Intravenous aminophylline.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aminophylline; Asthma; Body Weight; Child; Half-Life | 1979 |
Placental transfer of theophylline: two case reports.
Topics: Administration, Oral; Aminophylline; Asthma; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn | 1979 |
Quantitative effect of theophylline anhydrous on exercise-induced asthma after maximal physical effort.
Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Child; Dose-Response Relationship, Drug; Female; Force | 1979 |
Non-compliance in asthmatic children: a study of theophylline levels in a pediatric emergency room population.
Topics: Adolescent; Asthma; Bronchodilator Agents; Child; Child, Preschool; Emergency Service, Hospital; Fem | 1979 |
Differential effects of pharmacologic agents on EAC3 rosette formation by lymphocytes from normal and asthmatic subjects.
Topics: Adolescent; Adult; Animals; Asthma; Cattle; Child; Child, Preschool; Cholera Toxin; Complement C3; E | 1979 |
Comparison of theophylline concentrations in venous blood and capillary blood in asthmatic children.
Topics: Adolescent; Asthma; Blood Specimen Collection; Capillaries; Child; Child, Preschool; Female; Humans; | 1979 |
Management of the child with asthma.
Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Child; Food Hypersensitivity; Humans; Immuno | 1979 |
[Measurement of blood theophylline levels in the child: will this affect methods of prescription? (author's transl)].
Topics: Adolescent; Asthma; Child; Child, Preschool; Erythromycin; Female; Humans; Male; Theophylline | 1979 |
Slow-release theophylline preparations.
Topics: Asthma; Child; Chronic Disease; Delayed-Action Preparations; Humans; Theophylline | 1979 |
Pharmacokinetics of theophylline in young children with asthma: comparison of rectal enema and suppositories.
Topics: Age Factors; Asthma; Child, Preschool; Enema; Humans; Infant; Injections, Intravenous; Kinetics; Rec | 1979 |
Factors that influence theophylline metabolism.
Topics: Adolescent; Adult; Age Factors; Asthma; Biotransformation; Cannabis; Child; Child, Preschool; Diet; | 1979 |
Terbutaline and terbutaline combined with theophylline in asthmatics.
Topics: Administration, Oral; Aerosols; Asthma; Drug Evaluation; Drug Therapy, Combination; Humans; Injectio | 1979 |
Respiratory and circulatory interactions of salbutamol and theophyllamine in asthmatic patients.
Topics: Adolescent; Adult; Albuterol; Asthma; Double-Blind Method; Drug Interactions; Female; Hemodynamics; | 1979 |
Laboratory evaluation of exercise-induced asthma: methodologic considerations.
Topics: Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Fenoterol; Forced Expiratory V | 1979 |
Bronchodilators.
Topics: Adrenal Cortex Hormones; Asthma; Bronchial Spasm; Bronchitis; Bronchodilator Agents; Drug Combinatio | 1979 |
Serum theophylline levels in asthmatic children receiving sustained-release theophylline tablets.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Tablets; The | 1979 |
Dose-titration comparison of inhaled salbutamol and oral theophylline in asthma.
Topics: Administration, Oral; Adult; Aerosols; Aged; Albuterol; Asthma; Dose-Response Relationship, Drug; Fo | 1979 |
Clinical and pharmacological observations on a new microcrystalline theophylline preparation.
Topics: Adult; Aged; Asthma; Crystallization; Female; Humans; Lung Volume Measurements; Male; Middle Aged; T | 1979 |
Inhibition of artifically-induced asthma by reproterol ('Bronchospasmin').
Topics: Adult; Asthma; Blood Pressure; Bronchodilator Agents; Drug Combinations; Female; Humans; Male; Metap | 1979 |
Asthma--a possible interaction between hydrocortisone and theophylline.
Topics: Asthma; Drug Interactions; Humans; Hydrocortisone; Theophylline | 1979 |
Rapid assay for theophylline in clinical samples by reversed-phase high-performance liquid chromatography.
Topics: Asthma; Chromatography, High Pressure Liquid; Humans; Theophylline | 1979 |
Simultaneous use of rapidly absorbed and sustained release theophylline preparations in children.
Topics: Absorption; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Male; Theo | 1979 |
Aminophylline therapy in children: guidelines for dosage.
Topics: Administration, Oral; Adolescent; Aminophylline; Asthma; Child; Child, Preschool; Dose-Response Rela | 1977 |
Use of a twelve-hour theophylline preparation in chronic adult asthmatics.
Topics: Adolescent; Adult; Aged; Asthma; Chronic Disease; Circadian Rhythm; Female; Forced Expiratory Volume | 1979 |
Oral aminophylline therapy. Increased dosage requirements in children.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Aminophylline; Asthma; Child; Child, Pre | 1977 |
Hemodialysis clearance of theophylline.
Topics: Asthma; Biotransformation; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Kidney Failur | 1977 |
Theophylline concentrations in asthmatic patients after administration of aminophylline.
Topics: Adolescent; Adult; Aged; Aminophylline; Asthma; Female; Half-Life; Humans; Infusions, Parenteral; Ma | 1977 |
[The pharmacology of 1-propyl-3-methyl-7-(5-hydroxyhexyl) xanthine (HWA 153), a new bronchodilatory xanthine derivative].
Topics: Animals; Asthma; Bronchodilator Agents; Central Nervous System; Coronary Circulation; Female; Guinea | 1979 |
Urinary excretion of methylated purines in man and in the rat after the administration of theophylline.
Topics: Allopurinol; Animals; Asthma; Child; Chromatography, High Pressure Liquid; Chromatography, Thin Laye | 1979 |
Acute and chronic theophylline therapy in exercise-induced bronchospasm.
Topics: Acute Disease; Adolescent; Asthma; Bronchial Spasm; Child; Chronic Disease; Drug Tolerance; Female; | 1977 |
[Multicenter controlled clinical evaluation of the drug, metet].
Topics: Antihypertensive Agents; Asthma; Coronary Disease; Drug Evaluation; Humans; Hypertension; Theophylli | 1977 |
Theophylline: what dosage.
Topics: Age Factors; Asthma; Child; Humans; Male; Theophylline | 1977 |
Oral theophylline dosage for the management of chronic asthma.
Topics: Administration, Oral; Adolescent; Age Factors; Asthma; Child; Child, Preschool; Chronic Disease; Hum | 1978 |
Therapeutic synergism.
Topics: Asthma; Drug Synergism; Ephedrine; Humans; Hydroxyzine; Metaproterenol; Terminology as Topic; Theoph | 1978 |
The treatment of asthma.
Topics: Asthma; Drug Therapy, Combination; Humans; Sympathomimetics; Theophylline | 1978 |
[Accidental poisoning with suppositories containing a combination of theophyllin, dimethylaminophenazone, sympathicomimetic and vagolytic agents in a 15 months old child (Asthma 23 D) (author's transl)].
Topics: Aminopyrine; Asthma; Bronchodilator Agents; Drug Combinations; Female; Humans; Infant; Parasympathol | 1978 |
Evaluation of a program for the pharmacologic management of children with asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Child; Child, Preschool; Evaluat | 1978 |
Liquid preparations of theophylline for oral use.
Topics: Administration, Oral; Asthma; Child; Female; Humans; Theophylline | 1978 |
Pharmacokinetics of oral theophylline in asthmatic children: evaluation of a new preparation, "Theolair".
Topics: Administration, Oral; Adolescent; Asthma; Child; Drug Evaluation; Female; Forced Expiratory Volume; | 1978 |
Effect of practical timing of dosage on theophylline blood levels in asthmatic children treated with choline theophyllinate.
Topics: Administration, Oral; Adolescent; Asthma; Child; Child, Preschool; Humans; Infant; Theophylline; Tim | 1978 |
Clinical applications of serum theophylline measurement by high pressure liquid chromatography.
Topics: Adolescent; Asthma; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Infant; N | 1978 |
A re-evaluation of ephedrine/theophylline combinations in the treatment of asthma.
Topics: Asthma; Drug Synergism; Drug Therapy, Combination; Ephedrine; Humans; Theophylline | 1978 |
The treatment of asthma.
Topics: Adult; Aminophylline; Asthma; Bronchodilator Agents; Humans; Terbutaline; Theophylline | 1978 |
[Comparison between intravenous administration of salbutamol and theophylline in asthma].
Topics: Albuterol; Asthma; Humans; Theophylline | 1978 |
[Acute dyspnea].
Topics: Adrenal Cortex Hormones; Airway Obstruction; Anti-Arrhythmia Agents; Asthma; Diagnosis, Differential | 1978 |
[Long-term effect and tolerance of broncholytics].
Topics: Adult; Aerosols; Aged; Albuterol; Asthma; Drug Resistance; Drug Tolerance; Fenoterol; Hexoprenaline; | 1978 |
Exercise, induced bronchospasm in asthmatic children as a dose-response model for theophylline.
Topics: Adolescent; Asthma; Bronchial Spasm; Child; Dose-Response Relationship, Drug; Female; Forced Expirat | 1978 |
[Value of blood theophylline determination].
Topics: Animals; Asthma; Humans; Theophylline | 1978 |
Disposition of theophylline after a single intravenous infusion of aminophylline.
Topics: Adult; Aminophylline; Asthma; Dose-Response Relationship, Drug; Female; Humans; Infusions, Parentera | 1978 |
Irreversibility of obstructive changes in severe asthma in childhood.
Topics: Adolescent; Airway Obstruction; Aminophylline; Asthma; Child; Humans; Infant, Newborn; Lung; Lung Vo | 1978 |
Guide to oral theophylline therapy for the treatment of chronic asthma.
Topics: Administration, Oral; Adult; Asthma; Capsules; Child; Chronic Disease; Delayed-Action Preparations; | 1978 |
Dose of theophylline for asthma.
Topics: Asthma; Humans; Theophylline | 1978 |
[Drug information. Nuelin].
Topics: Adult; Asthma; Child; Humans; Theophylline | 1978 |
Theophylline disposition in acutely ill hospitalized patients. The effect of smoking, heart failure, severe airway obstruction, and pneumonia.
Topics: Acute Disease; Adult; Aged; Airway Obstruction; Asthma; Bronchitis; Chronic Disease; Female; Half-Li | 1978 |
Sustained-release theophylline therapy for chronic childhood asthma.
Topics: Adolescent; Asthma; Biological Availability; Child; Chronic Disease; Delayed-Action Preparations; Fe | 1978 |
Pharmacokinetics of delayed (DR) versus sustained release (SR) theophylline formulations following single (SD) and repetitive dosing (RD).
Topics: Adult; Asthma; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Theophylline; Ti | 1978 |
Effect of ampicillin on theophylline half-life in infants and young children.
Topics: Ampicillin; Asthma; Child; Child, Preschool; Drug Synergism; Half-Life; Humans; Infant; Retrospectiv | 1978 |
Serum theophylline concentrations and pulmonary mechanical functions following single and steady-state dosing with a sustained-release theophylline capsule.
Topics: Adult; Asthma; Capsules; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Humans; | 1978 |
Serum theophylline concentrations in asthmatic children.
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Infant; Male; Theophylline; Time Factor | 1978 |
[The pharmacokinetics of intravenous theophylline (author's transl)].
Topics: Asthma; Humans; Injections, Intravenous; Theophylline | 1978 |
Serum theophylline levels in asthmatic children after oral administration of two slow-release theophylline preparations.
Topics: Administration, Oral; Adolescent; Age Factors; Asthma; Child; Child, Preschool; Delayed-Action Prepa | 1978 |
Exercise-induced asthma--clinical, physiological, and therapeutic implications.
Topics: Adrenal Cortex Hormones; Adult; Airway Resistance; Aminophylline; Asthma; Atropine; Bronchodilator A | 1975 |
Theophylline and ephedrine in asthma.
Topics: Adult; Asthma; Child; Drug Combinations; Drug Therapy, Combination; Ephedrine; Humans; Sympathomimet | 1975 |
Managing the adolescent asthmatic.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Cromolyn Sodium; Diagnosis, Differential; Drug Therapy, | 1975 |
Therapeutic effectiveness of cromolyn sodium with 38 severely asthmatic children under five years of age.
Topics: Age Factors; Asthma; Child, Preschool; Cromolyn Sodium; Humans; Methods; Theophylline | 1976 |
Recent advances in bronchial asthma.
Topics: Asthma; Beclomethasone; Child; Child, Preschool; Cromolyn Sodium; Desensitization, Immunologic; Grow | 1976 |
New drugs in treatment of asthma.
Topics: Adrenal Cortex Hormones; Aerosols; Asthma; Bronchodilator Agents; Cromolyn Sodium; Humans; Parasympa | 1976 |
Asthma therapy - 1977.
Topics: Administration, Intranasal; Adrenal Cortex Hormones; Aerosols; Asthma; Bronchodilator Agents; Cromol | 1976 |
Aminophylline bioavailability and the across-time stability of plasma theophylline levels.
Topics: Adolescent; Aminophylline; Asthma; Biological Availability; Child; Female; Humans; Male; Theophyllin | 1977 |
Theophylline, a review.
Topics: Aminophylline; Asthma; Bronchial Spasm; Dose-Response Relationship, Drug; Humans; Lung Diseases, Obs | 1977 |
A simple office procedure for the monitoring of theophylline levels in asthma.
Topics: Asthma; Humans; Methods; Spectrophotometry, Ultraviolet; Theophylline | 1977 |
Variation in theophylline clearance rate with time in chronic childhood asthma.
Topics: Adolescent; Asthma; Child; Chronic Disease; Female; Humans; Male; Theophylline; Time Factors | 1977 |
Pharmacokinetics in drug therapy II: Applications of clinical pharmacokinetics in the assessment of theophylline therapy.
Topics: Administration, Oral; Adult; Aminophylline; Asthma; Biological Availability; Enema; Female; Humans; | 1977 |
Intrapatient variability in theophylline kinetics.
Topics: Adolescent; Asthma; Child; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Respiratory Fu | 1977 |
A child with theophylline poisoning.
Topics: Asthma; Blood Circulation; Blood Transfusion; Brain Edema; Child, Preschool; Coma; Digoxin; Heart Ma | 1977 |
The pharmacological basis of bronchodilator therapy.
Topics: Asthma; Bronchodilator Agents; Humans; Sympathomimetics; Theophylline | 1977 |
Management of infantile asthma.
Topics: Asthma; Bronchiolitis, Viral; Child, Preschool; Diagnosis, Differential; Ephedrine; Food Hypersensit | 1977 |
Reliability of salivary theophylline as a guide to plasma theophylline levels.
Topics: Adolescent; Asthma; Child; Chromatography, Liquid; Chronic Disease; Humans; Saliva; Theophylline | 1977 |
Variation in theophylline clearance rate.
Topics: Adolescent; Asthma; Child; Humans; Metabolic Clearance Rate; Theophylline | 1977 |
Relationship of theophylline clearance to oral dosage in children with chronic asthma.
Topics: Administration, Oral; Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Female; Humans; | 1977 |
Dose-dependent kinetics of theophylline disposition in asthmatic children.
Topics: Adolescent; Asthma; Biotransformation; Child; Child, Preschool; Dose-Response Relationship, Drug; Fe | 1977 |
Inhibition of histamin-induced airway constriction negative results with oxtriphylline and ascorbic acid.
Topics: Ascorbic Acid; Asthma; Constriction, Pathologic; Histamine; Theophylline | 1977 |
[Intravenous influsion of theophyllamine].
Topics: Adult; Aged; Asthma; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Nausea; Theophylline | 1977 |
New drugs for asthma: a scientific basis for therapy.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Child; Humans; Pediatrics; Theophylline | 1977 |
[Treatment of bronchospastic attack and the asthmatic state].
Topics: Albuterol; Asthma; Bronchial Spasm; Drug Combinations; Drug Evaluation; Ephedrine; Humans; Prednisol | 1977 |
Advances in management of chronic asthma in children.
Topics: Asthma; Child; Child, Preschool; Chronic Disease; Female; Humans; Male; Saliva; Theophylline | 1977 |
[Letter: Bronchial asthma. Treatment in general practice].
Topics: Adult; Aerosols; Aged; Asthma; Chronic Disease; Dexamethasone; Epinephrine; Female; Humans; Immunoth | 1976 |
Intravenous aminophylline dosage. Use of serum theophylline measurement for guidance.
Topics: Acute Disease; Adult; Age Factors; Asthma; Bronchial Spasm; Child; Humans; Infusions, Parenteral; Me | 1976 |
Therapeutic efficacy of a new anhydrous theophylline dosage form.
Topics: Adolescent; Adult; Asthma; Child; Female; Humans; Male; Middle Aged; Theophylline | 1976 |
Deaths due to childhood asthma. Are they preventable?
Topics: Adolescent; Adrenal Cortex Hormones; Aerosols; Asthma; Bronchitis; Child; Child, Preschool; Female; | 1976 |
Theophylline in asthma.
Topics: Adult; Asthma; Child; Humans; Kinetics; Theophylline; Time Factors | 1976 |
The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment.
Topics: Administration, Oral; Adult; Asthma; Biological Availability; Drug Therapy, Combination; Drug Tolera | 1976 |
Asthma in children.
Topics: Adrenal Cortex Hormones; Asthma; Child; Epinephrine; Humans; Infant; Isoproterenol; Theophylline | 1976 |
[Clinical pharmacology of theophyllin in bronchial asthma].
Topics: Asthma; Humans; Theophylline | 1976 |
[Asthma].
Topics: Adrenal Cortex Hormones; Adult; Asthma; Child; Child, Preschool; Humans; Theophylline | 1975 |
Intravenous salbutamol in management of status asthmaticus.
Topics: Acute Disease; Adolescent; Adult; Albuterol; Asthma; Beclomethasone; Carbon Dioxide; Female; Humans; | 1975 |
Allergic granulomatous angiitis (Churg-Strauss syndrome).
Topics: Adolescent; Arteritis; Asthma; Blood Cell Count; Body Weight; Drug Therapy, Combination; Eosinophili | 1975 |
Gas-chromatographic determination of theophylline in human serum and saliva.
Topics: Asthma; Child; Chromatography, Gas; Evaluation Studies as Topic; Humans; Methods; Microchemistry; Ph | 1975 |
Oral theophylline drugs for asthma.
Topics: Administration, Oral; Asthma; Bronchodilator Agents; Drug Combinations; Ephedrine; Humans; Pentobarb | 1975 |
Dosage of theophylline in bronchial asthma.
Topics: Acute Disease; Administration, Oral; Adult; Asthma; Chemical Phenomena; Chemistry; Child; Chronic Di | 1975 |
Pharmacokinetic analysis of the effect of theophylline on pulmonary function in asthmatic children.
Topics: Adolescent; Age Factors; Asthma; Child; Child, Preschool; Computers; Dose-Response Relationship, Dru | 1975 |
Rational use of oral theophylline in the treatment of chronic asthma.
Topics: Administration, Oral; Asthma; Chronic Disease; Humans; Theophylline | 1975 |
[Symptomatic treatment of bronchial asthma in children].
Topics: Asthma; Child; Drug Therapy, Combination; Humans; Sympathomimetics; Theophylline | 1975 |
Letter: Use of theophylline in asthma.
Topics: Administration, Oral; Adult; Age Factors; Asthma; Child; Humans; Theophylline; Time Factors | 1975 |
Current status of the use of intravenously administered aminophylline.
Topics: Adolescent; Aminophylline; Asthma; Child; Chromatography, Gas; Humans; Infusions, Parenteral; Theoph | 1975 |
Letter: Theophylline.
Topics: Alkalosis, Respiratory; Asthma; Epilepsy; Humans; Theophylline | 1975 |
The pharmacokinetics of dihydroxypropyltheophylline: a basis for rational therapy.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Biological Availability; Dose-Response Relationship | 1975 |
Theophylline toxicity in an infant.
Topics: Asthma; Dose-Response Relationship, Drug; Female; Humans; Infant; Theophylline | 1975 |
[Long-term out-patient treatment of children with asthma with a theophylline-ephedrine-hydroxyzine combination (author's transl)].
Topics: Adolescent; Ambulatory Care; Asthma; Child; Child, Preschool; Drug Therapy, Combination; Ephedrine; | 1975 |
Plasma level and broncholytic effect of choline theophyllinate after a single dose of a press-coated tablet formulation.
Topics: Adult; Asthma; Bronchi; Choline; Female; Forced Expiratory Volume; Humans; Isoproterenol; Kinetics; | 1975 |
The acute and chronic bronchodilator effects of ephedrine in asthmatic patients.
Topics: Administration, Oral; Asthma; Blood Pressure; Bronchodilator Agents; Drug Administration Schedule; D | 1975 |
Letter: Status asthmaticus.
Topics: Adult; Age Factors; Asthma; Child, Preschool; Humans; Theophylline | 1975 |
Influence of formulation on bioavailability of theophylline.
Topics: Adult; Asthma; Biological Availability; Drug Combinations; Drug Compounding; Ephedrine; Female; Huma | 1976 |
[Comparative study of the effect of some bronchodilator substances].
Topics: Aged; Albuterol; Aminophylline; Asthma; Bronchial Diseases; Bronchodilator Agents; Doxylamine; Drug | 1976 |
Compliance of chronic asthmatics with oral administration of theophylline as measured by serum and salivary levels.
Topics: Administration, Oral; Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Humans; Patient | 1976 |
[Effects of theophylline on the respiratory system].
Topics: Animals; Asthma; Bronchodilator Agents; Cardiovascular System; Diaphragm; Histamine Release; Humans; | 1992 |
[The effect of mexiletine on theophylline pharmacokinetics in patients with bronchial asthma].
Topics: Aged; Aged, 80 and over; Asthma; Cardiac Complexes, Premature; Drug Interactions; Female; Humans; Ma | 1992 |
Criteria for use of theophylline (aminophylline) in inpatients and outpatients with pulmonary disease.
Topics: Ambulatory Care; Asthma; Drug Utilization; Hospitalization; Humans; Lung Diseases, Obstructive; Theo | 1992 |
Adenosine-induced bronchoconstriction in an allergic rabbit model: antagonism by theophylline aerosol.
Topics: Adenosine; Aerosols; Anesthesia; Animals; Asthma; Bronchial Hyperreactivity; Histamine; Pollen; Rabb | 1992 |
Modification of allergen-induced airway obstruction and bronchial hyperresponsiveness in the allergic rabbit by theophylline aerosol.
Topics: Aerosols; Airway Obstruction; Airway Resistance; Allergens; Animals; Asthma; Bronchial Hyperreactivi | 1992 |
Neutrophils from asthmatics exhibit diminished responsiveness to 2-chloroadenosine which is reversed by theophylline. Evidence for a cyclic-AMP-independent pathway on human neutrophils.
Topics: 2-Chloroadenosine; Adult; Asthma; Cyclic AMP; Drug Synergism; Female; Humans; Male; Middle Aged; N-F | 1992 |
Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes.
Topics: Adult; Analysis of Variance; Asthma; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; I | 1992 |
Induction by aerosol allergen of sustained and nonspecific IgE-mediated airway hyperreactivity in the guinea pig.
Topics: Acetylcholine; Aerosols; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Diphenhydramine; Gui | 1992 |
Premenstrual asthma with seasonal variation.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Allergens; Animals; Antibodies; Antigen | 1992 |
[Treatment understanding and compliance in asthma of children. Results of a prospective survey].
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Child; Child, Preschoo | 1992 |
[Current concept on therapy of asthma and pollenosis].
Topics: Adrenergic beta-Agonists; Allergens; Animals; Asthma; Bronchial Provocation Tests; Desensitization, | 1992 |
[Asthma in the elderly].
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Aged; Asthma; Beclomethasone; Cromolyn Sodium; | 1992 |
[Diagnosis, physiopathology and therapy of bronchial asthma: discussion].
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Asthma; Bronchial Hyperreactivity; Desensitiza | 1992 |
[Necessity and limitations of effectiveness of oral beta-stimulants, theophylline and oral antiallergic drugs in asthma treatment].
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Beclomethasone; His | 1992 |
Cytogenetic study in peripheral blood lymphocytes from asthmatic patients receiving continued therapy with theophylline.
Topics: Adolescent; Adult; Animals; Asthma; Cell Division; Cells, Cultured; Chromosome Aberrations; Drug The | 1992 |
Variability of the serum protein binding of theophylline in patients with asthma and cystic fibrosis.
Topics: Adolescent; Adult; Aged; Asthma; Blood Proteins; Chromatography, High Pressure Liquid; Cystic Fibros | 1992 |
High-dose systemic glucocorticoid therapy in the treatment of severe asthma: a case of resistance and patterns of response.
Topics: Administration, Inhalation; Adolescent; Albuterol; Asthma; Child; Dose-Response Relationship, Drug; | 1992 |
Development of an animal model of late asthmatic response in guinea pigs and effects of anti-asthmatic drugs.
Topics: Albuterol; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cromolyn Sodium; Cytodiagnosis; | 1992 |
Choreiform movements observed in an 8-year-old child following use of an oral theophylline preparation.
Topics: Administration, Oral; Asthma; Child; Chorea; Humans; Male; Theophylline; Tremor | 1992 |
Clearance of theophylline by hemodialysis in one patient with chronic renal failure.
Topics: Aminophylline; Asthma; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Theophyll | 1992 |
Could saliva stand for plasma in theophylline monitoring in asthmatic children? Still a controversial problem.
Topics: Adult; Asthma; Child; Delayed-Action Preparations; Drug Monitoring; Female; Humans; Male; Saliva; Th | 1992 |
A prospective trial using salivary-theophylline levels to guide asthma therapy.
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Humans; Prospective Studie | 1992 |
Pharmacokinetics of low-dose methotrexate in adult asthmatics.
Topics: Adolescent; Adult; Aged; Asthma; Drug Administration Schedule; Female; Half-Life; Humans; Injections | 1992 |
[The effect of theophylline on purine receptor function in bronchial asthma patients].
Topics: Adolescent; Adult; Asthma; Chromatography, High Pressure Liquid; Humans; Lymphocytes; Middle Aged; R | 1992 |
Pharmacokinetic consultation program in a pediatric asthma clinic.
Topics: Asthma; Child; Child, Preschool; Humans; Outpatient Clinics, Hospital; Patient Education as Topic; P | 1992 |
Massive theophylline dosing in a heavy smoker receiving both phenytoin and phenobarbital.
Topics: Adult; Asthma; Drug Administration Schedule; Female; Humans; Phenobarbital; Phenytoin; Seizures; Smo | 1992 |
Correlations between theophylline concentrations in plasma, erythrocytes and cantharides-induced blister fluid and peak expiratory flow in asthma patients.
Topics: Asthma; Blister; Body Fluids; Cantharidin; Dose-Response Relationship, Drug; Erythrocytes; Humans; I | 1992 |
[Therapeutic non-compliance with theophylline preparations in ambulatory treatment].
Topics: Adult; Ambulatory Care; Asthma; Child; Female; Humans; Lung Diseases, Obstructive; Male; Patient Com | 1992 |
Does asthma or treatment with theophylline limit children's academic performance?
Topics: Adrenal Cortex Hormones; Asthma; Child; Educational Measurement; Female; Humans; Intelligence; Male; | 1992 |
[Inhaled glucocorticoids. Slight side effects at high effectiveness].
Topics: Administration, Oral; Adolescent; Adult; Asthma; Beclomethasone; Child; Glucocorticoids; Humans; Pro | 1992 |
Relationship between serum and saliva theophylline levels in patients with cystic fibrosis.
Topics: Adolescent; Adult; Asthma; Child; Cystic Fibrosis; Humans; Lung Diseases; Regression Analysis; Saliv | 1992 |
[Principles of theophylline therapy in obstructive respiratory diseases].
Topics: Asthma; Humans; Lung Diseases, Obstructive; Theophylline | 1992 |
[Examination of theophylline pharmacokinetics during an attack of bronchial asthma in children].
Topics: Adolescent; Aminophylline; Analysis of Variance; Asthma; Child; Child, Preschool; Female; Half-Life; | 1992 |
Methotrexate treatment of severe asthma in children.
Topics: Adolescent; Albuterol; Asthma; Beclomethasone; Body Height; Body Weight; Child; Child, Preschool; Cr | 1992 |
Lipoprotein profile of children with asthma receiving long-term theophylline therapy: a preliminary study.
Topics: Apolipoproteins; Asthma; Child; Cholesterol; Cholesterol, HDL; Coronary Artery Disease; Cross-Sectio | 1992 |
Management of asthma.
Topics: Albuterol; Asthma; Child; Child, Preschool; Emergencies; Female; Hospitalization; Humans; Male; Oxyg | 1992 |
Morbidity associated with asthma and audit of asthma treatment in out-patient clinics.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Asthma; Child; Drug Therapy, Combination; Female; Humans; | 1992 |
Plasma theophylline concentrations and airway function in asthmatic children receiving standard and modified RTC therapy.
Topics: Asthma; Child; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedule; Female; | 1992 |
[The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma].
Topics: Adult; Aged; Asthma; Female; Half-Life; Humans; Male; Middle Aged; Quinolones; Theophylline | 1991 |
Theophylline therapy inhibits neutrophil and mononuclear cell chemotaxis from chronic asthmatic children.
Topics: Asthma; Chemotaxis, Leukocyte; Child; Complement C3; Complement C4; Cyclic AMP; Female; Humans; Immu | 1991 |
The randomized concentration-controlled trial: an evaluation of its sample size efficiency.
Topics: Administration, Oral; Asthma; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Mo | 1991 |
Drugs for ambulatory asthma.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Am | 1991 |
Inhaled steroids for chronic asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Chronic Di | 1991 |
Will I get addicted to my asthma treatment?
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Drug Tolerance; Humans; Parasympatholytic | 1991 |
Asthma management in general practice.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Asthma; Australia; Child; Family Practi | 1991 |
The role of theophyllines in a preventive approach for subjects with both mild and severe asthma.
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Child; Drug Therapy, Combination; Humans; Lung; Theoph | 1991 |
Interaction between theophylline and mexiletine.
Topics: Aged; Asthma; Cardiac Complexes, Premature; Drug Interactions; Heart Block; Humans; Male; Mexiletine | 1990 |
[An immunoenzyme method of controlling the concentration of theophylline in the blood of children with bronchial asthma during treatment with theophylline preparations].
Topics: Asthma; Child; Humans; Immunoenzyme Techniques; Theophylline | 1991 |
Unstable asthma and theophylline.
Topics: Asthma; Humans; Peak Expiratory Flow Rate; Theophylline | 1992 |
Outpatient compliance with theophylline and phenytoin therapy.
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newbor | 1991 |
Unstable asthma and theophylline.
Topics: Adult; Asthma; Circadian Rhythm; Female; Humans; Peak Expiratory Flow Rate; Theophylline | 1991 |
Acute asthma in children.
Topics: Acute Disease; Albuterol; Asthma; Emergencies; Humans; Patient Education as Topic; Theophylline | 1991 |
[A case of sustained-release theophylline (Theodur)-induced asthma].
Topics: Adult; Asthma; Delayed-Action Preparations; Humans; Male; Theophylline | 1991 |
Pharmacokinetics of theophylline and its metabolites during acute renal failure. A case report.
Topics: Acute Kidney Injury; Asthma; Child, Preschool; Humans; Male; Metabolic Clearance Rate; Peritoneal Di | 1991 |
Steady-state population pharmacokinetics of sustained release theophylline in adult asthmatic patients.
Topics: Adult; Aged; Asthma; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Models, Biologi | 1991 |
Theophylline disposition in adolescents with asthma.
Topics: Adolescent; Ambulatory Care; Asthma; Body Mass Index; Child; Drug Administration Schedule; Female; H | 1991 |
A study on the chronopharmacokinetics of theophylline in rabbits.
Topics: Administration, Oral; Animals; Asthma; Circadian Rhythm; Drug Administration Schedule; Male; Rabbits | 1991 |
Evaluation of slow-release theophylline pharmacokinetics by Fourier's harmonic analysis.
Topics: Absorption; Adult; Asthma; Biological Availability; Delayed-Action Preparations; Fourier Analysis; H | 1991 |
[Prednisolone-dependent asthma patients--often under-treated in ambulatory care? Results of a retrospective study].
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Aged; Ambulatory Care; Asthma; | 1991 |
Use of troleandomycin as a steroid-sparing agent in both asthma and chronic obstructive pulmonary disease.
Topics: Adrenal Cortex Hormones; Aged; Asthma; Female; Humans; Lung Diseases, Obstructive; Male; Methylpredn | 1991 |
[Chronotherapy concept and the pharmacokinetic validation of a theophylline retard preparation for once-nightly administration (Euphylong)].
Topics: Asthma; Circadian Rhythm; Dose-Response Relationship, Drug; Food; Humans; Theophylline; Therapeutic | 1991 |
[Long-term stability of morning serum theophylline level in asthma patients under minimally 1-year therapy with Euphylong].
Topics: Adult; Aged; Asthma; Circadian Rhythm; Female; Humans; Longitudinal Studies; Male; Middle Aged; Peak | 1991 |
[Pharmacokinetics and pharmacodynamics of twice-daily unequal administration of theophylline retard pellets in children of various age groups].
Topics: Adolescent; Asthma; Child; Drug Administration Schedule; Female; Humans; Male; Respiratory Function | 1991 |
When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.
Topics: Adolescent; Adult; Aged; Asthma; Child; Female; Humans; Injections, Intravenous; Lung Diseases, Obst | 1991 |
Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.
Topics: Albuterol; Animals; Asthma; Bronchial Hyperreactivity; Chemotaxis, Leukocyte; Guinea Pigs; Male; Pla | 1991 |
[Asthma mortality and beta agonist drugs. The case of fenoterol].
Topics: Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adult; Asthma; Child; Child, Preschool; F | 1991 |
T cell receptor gamma delta bearing cells are decreased in the peripheral blood of patients with atopic diseases.
Topics: Adolescent; Adult; Albuterol; Antibodies, Monoclonal; Asthma; Beclomethasone; CD8 Antigens; Child; C | 1991 |
Methylxanthines in the treatment of asthma: the rise, the fall, and the possible rise again.
Topics: Aminophylline; Asthma; Drug Therapy; Humans; Theophylline | 1991 |
Effect of theophylline on urinary excretion of 3-methylhistidine in patients with lung disease.
Topics: Adult; Aged; Asthma; Blood Urea Nitrogen; Creatinine; Female; Humans; Lung Diseases, Obstructive; Ma | 1991 |
Serum/saliva correlations for theophylline in asthmatics.
Topics: Administration, Oral; Adult; Aged; Asthma; Feasibility Studies; Humans; Middle Aged; Predictive Valu | 1991 |
Outcomes of emergency room treatment of children with asthma.
Topics: Asthma; Child; Emergency Service, Hospital; Female; Humans; Male; Outcome and Process Assessment, He | 1991 |
Pulmonary function in a hospital population of asthmatic children.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Asthma; Child; Delayed-Actio | 1991 |
[Studies of free theophylline in asthmatic patients].
Topics: Adolescent; Adult; Aged; Asthma; Blood; Child; Child, Preschool; Female; Humans; Hydrogen-Ion Concen | 1991 |
Pharmacologic control of plasma exudation into tracheobronchial airways.
Topics: Animals; Asthma; Bronchi; Bronchodilator Agents; Capillary Permeability; Cromolyn Sodium; Guinea Pig | 1991 |
Clinical audit of theophylline use in general practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Child; Drug Monitoring; Evaluation Studies as To | 1991 |
Theophyllines in the treatment of asthma.
Topics: Asthma; Humans; Theophylline | 1991 |
Theophylline or physician toxicity?
Topics: Asthma; Humans; Malpractice; Theophylline | 1991 |
[Effects of long-term administration of theophylline on the pituitary-thyroid axis in asthmatics].
Topics: Adult; Aged; Asthma; Delayed-Action Preparations; Female; Humans; Hydrocortisone; Male; Middle Aged; | 1991 |
[A comparative study of the pharmacokinetics and urinary metabolites of sustained-release theophylline syrup, granule and tablet preparations].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Dosage Forms; Female; Huma | 1991 |
Aminophylline in the emergency department. Maximizing safety and efficacy.
Topics: Acute Disease; Aminophylline; Asthma; Drug Therapy, Computer-Assisted; Emergency Service, Hospital; | 1991 |
Pharmacological and toxicological activities of a new methylxanthine derivative [7-(1,3-dithiolan-2-ylmethyl)1,3-dimethylxanthine] with antibronchospastic and mucoregulatory properties.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminophylline; Animals; Antitussive Agents; Asthma; Bronchial S | 1990 |
Asthma therapy: present trends and future prospects.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Humans; Nebulizers and Vaporizers; Parasy | 1990 |
Prevalence and management of asthma in a London inner city general practice.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Bronch | 1990 |
[Treatment of acute crisis of chronic respiratory failure].
Topics: Asthma; Chronic Disease; Histamine H1 Antagonists; Humans; Lung Diseases, Obstructive; Pulmonary Fib | 1990 |
[The influence of serum theophylline concentration on the bronchodilating effect of salbutamol inhalation for bronchial asthma].
Topics: Administration, Inhalation; Adolescent; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Br | 1990 |
Asthma therapy and mortality.
Topics: Adrenergic beta-Agonists; Asthma; Australia; Bronchodilator Agents; Humans; Theophylline | 1990 |
Use of antiasthmatic drugs in Australia.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adrenal Cortex Hormones; Adrenergic be | 1990 |
Therapeutic implications of a precise diagnosis of airflow obstruction.
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Humans; Lung Diseases, Obstructive; Parasym | 1990 |
Dependence of the renal excretion of theophylline on its plasma concentrations and urine flow rate in asthmatic children.
Topics: Administration, Oral; Adolescent; Aminophylline; Asthma; Child; Child, Preschool; Delayed-Action Pre | 1990 |
Abnormalities in airway smooth muscle in fatal asthma. A comparison between trachea and bronchus.
Topics: Acetylcholine; Adult; Asthma; Bronchi; Bronchoconstriction; Electric Stimulation; Female; Histamine; | 1991 |
Erythromycin reduces the severity of bronchial hyperresponsiveness in asthma.
Topics: Adult; Aged; Asthma; Bronchi; Bronchial Provocation Tests; Bronchitis; Erythromycin; Female; Forced | 1991 |
The effect of dapsone in steroid-dependent asthma.
Topics: Adult; Aged; Asthma; Dapsone; Drug Synergism; Female; Humans; Male; Middle Aged; Neutrophils; Peak E | 1991 |
Chronotherapy of reversible airways disease with once-daily evening doses of a controlled-release theophylline preparation.
Topics: Asthma; Circadian Rhythm; Delayed-Action Preparations; Humans; Lung Diseases, Obstructive; Theophyll | 1991 |
Brief report: poor bioavailability of sustained-release theophylline. A case for liquid theophylline.
Topics: Adult; Asthma; Biological Availability; Delayed-Action Preparations; Female; Humans; Theophylline | 1991 |
Bronchial challenge with adenosine causes the release of serum neutrophil chemotactic factor in asthma.
Topics: Adenosine; Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Chemotaxis, Leukocyte; F | 1991 |
Theophylline concentrations predicted by the Chiou method.
Topics: Aminophylline; Asthma; Humans; Predictive Value of Tests; Theophylline | 1991 |
The arrhythmogenicity of theophylline. A multivariate analysis of clinical determinants.
Topics: Aged; Arrhythmias, Cardiac; Asthma; Cross-Sectional Studies; Electrocardiography; Female; Heart Rate | 1991 |
Theophylline and status epilepticus in children.
Topics: Adolescent; Asthma; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencephalograph | 1991 |
["Blood level thinking" in clinical medicine].
Topics: Asthma; Digoxin; Drug Therapy; Heart Diseases; Humans; Theophylline | 1991 |
[The rehabilitation of bronchial asthma patients at a polyclinic].
Topics: Ambulatory Care; Asthma; Bronchodilator Agents; Chronic Disease; Combined Modality Therapy; Drug The | 1990 |
In vivo anti-inflammatory activity of 7-(1,3-dithiolan-2-ylmethyl)-1,3-dimethylxanthine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Capillary Permeability; Edema; Guinea Pigs | 1990 |
Permanent brain damage possibly caused by theophylline in two elderly patients with airway obstruction.
Topics: Aged; Asthma; Brain Diseases; Female; Humans; Lung Diseases, Obstructive; Male; Seizures; Theophylli | 1990 |
[Accelerated desensitization with Dermatophagoides pteronyssinus in severe asthmatic children. Evaluation after one year of immunotherapy].
Topics: Acari; Adolescent; Adrenal Cortex Hormones; Animals; Asthma; Child; Child, Preschool; Cromolyn Sodiu | 1990 |
Childhood asthma in Thailand.
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Infant; Male; Prognosis; Prospective St | 1990 |
Cromolyn versus theophylline for treatment of asthma.
Topics: Asthma; Child; Cromolyn Sodium; Humans; Theophylline | 1990 |
[Clinical effects of theophylline in the therapy of intractable asthmatic children. II. Theophylline therapy and behavior problems in children with asthma].
Topics: Administration, Inhalation; Adolescent; Asthma; Child; Child Behavior; Cromolyn Sodium; Drug Therapy | 1990 |
Comment on the paper by M. Garty et al.: "Increased theophylline clearance by terbutaline in asthmatic patients" in European Journal of Clinical Pharmacology, issue 1 vol. 36, pp 25-28, 1989.
Topics: Asthma; Drug Interactions; Humans; Terbutaline; Theophylline | 1990 |
[Treatment with sustained theophylline release. Monitoring by salivary assay in children].
Topics: Adolescent; Asthma; Child; Child, Preschool; Humans; Saliva; Theophylline | 1990 |
The effects of theophylline on beta 2-adrenoceptors on polymorphonuclear leukocytes of asthmatic children and juveniles. Increase in receptor density and prevention of agonist-induced down-regulation.
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Down-Regulation; Female; Humans; Male; Neutrophi | 1990 |
Evaluation of beta-adrenergic function in normal and asthmatic children.
Topics: Albuterol; Asthma; Blood Glucose; Child; Epinephrine; Female; Humans; Male; Receptors, Adrenergic, b | 1990 |
[Determination of theophylline serum level: comparison between a rapid test (enzyme-immuno-chromatography) and conventional fluorescence polarization immunoassay].
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Fluorescence Polarization Immunoassay; Human | 1990 |
[Individualized euphylline therapy of children with refractory recurrent bronchial asthma controlled by therapeutic monitoring].
Topics: Adolescent; Asthma; Child; Child, Preschool; Circadian Rhythm; Drug Resistance; Humans; Monitoring, | 1990 |
Cardiovascular anomalies associated with prenatal exposure to theophylline.
Topics: Adult; Asthma; Drug Administration Schedule; Female; Heart Defects, Congenital; Humans; Infant, Newb | 1990 |
Guidelines for management of asthma.
Topics: Aged; Asthma; Humans; Methods; Theophylline | 1990 |
Asthma and pregnancy: responsibility of physicians and patients.
Topics: Administration, Inhalation; Adult; Asthma; Beclomethasone; Ephedrine; Fear; Female; Health Planning | 1990 |
Assessment of pediatric theophylline measurements.
Topics: Asthma; Child; Humans; Theophylline | 1990 |
[Posture and circadian variations in serum theophylline concentrations].
Topics: Adolescent; Asthma; Child; Circadian Rhythm; Female; Humans; Male; Posture; Theophylline | 1990 |
Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics.
Topics: Adult; Airway Resistance; Asthma; Female; Humans; Menstrual Cycle; Protein Binding; Theophylline | 1990 |
[A dose-concentration relationship study in different dosage regimens for theophylline preparations: intravenous for euphylline and peroral for prolonged-action forms].
Topics: Administration, Oral; Adult; Aged; Aminophylline; Asthma; Bronchial Spasm; Bronchitis; Chronic Disea | 1990 |
[Bronchodilator therapy in patients with bronchial asthma].
Topics: Aerosols; Asthma; Bronchodilator Agents; Humans; Parasympatholytics; Sympathomimetics; Theophylline | 1990 |
[Inhalation therapy for bronchial asthma. A. Bronchodilator--beta 2-stimulant].
Topics: Administration, Inhalation; Administration, Oral; Adult; Asthma; Bronchodilator Agents; Delayed-Acti | 1990 |
Comparison of unbound and total serum theophylline concentrations with those of stimulated and unstimulated saliva in asthmatic children.
Topics: Adolescent; Asthma; Blood Proteins; Child; Child, Preschool; Citrates; Citric Acid; Female; Humans; | 1990 |
Methylxanthines.
Topics: Asthma; Humans; Theophylline | 1990 |
Massive theophylline overdose with atypical metabolic abnormalities.
Topics: Adolescent; Asthma; Drug Overdose; Humans; Male; Substance-Related Disorders; Theophylline | 1990 |
Abnormalities in airway smooth muscle in fatal asthma.
Topics: Acetylcholine; Adult; Asthma; Cholinergic Fibers; Electric Stimulation; Female; Histamine; Humans; I | 1990 |
Death as a result of asthma in Wayne County Medical Examiner cases, 1975-1987.
Topics: Adolescent; Adult; Asthma; Black or African American; Cause of Death; Child; Female; Humans; Male; M | 1990 |
[Theopek in the treatment of patients with obstructive diseases of the respiratory organs].
Topics: Adult; Aged; Asthma; Bronchitis; Chronic Disease; Delayed-Action Preparations; Drug Evaluation; Fema | 1990 |
Maternal theophylline consumption and the risk of stillbirth.
Topics: Asthma; Cohort Studies; Female; Fetal Death; Humans; Pregnancy; Pregnancy Complications; Prospective | 1990 |
Treating asthma.
Topics: Asthma; Emergencies; Humans; Methylprednisolone; Theophylline | 1990 |
[Initial experiences with "Oranienburg" slow-release theophylline in asthma therapy of children and adolescents].
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Dose-Response Relationship, Drug; Female; Hu | 1990 |
[The clinical pharmacology of a new Soviet preparation theopek].
Topics: Adolescent; Adult; Aged; Aminophylline; Asthma; Bronchitis; Chronic Disease; Delayed-Action Preparat | 1990 |
Theophylline protein binding.
Topics: Adolescent; Adult; Aged; Asthma; Blood Proteins; Child; Dialysis; Female; Humans; Male; Middle Aged; | 1990 |
Effect of ozagrel (OKY-046), a thromboxane synthetase inhibitor, on theophylline pharmacokinetics in asthmatic patients.
Topics: Acrylates; Adult; Aged; Asthma; Drug Interactions; Female; Half-Life; Humans; Male; Methacrylates; M | 1990 |
Effect of theophylline on gastroesophageal reflux.
Topics: Asthma; Gastroesophageal Reflux; Humans; Theophylline | 1990 |
Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients.
Topics: Aged; Asthma; Bronchodilator Agents; Delayed-Action Preparations; Drug Interactions; Female; Humans; | 1990 |
General practice theophylline audit in the Exeter Health District.
Topics: Asthma; Dose-Response Relationship, Drug; Family Practice; Humans; Monitoring, Physiologic; Theophyl | 1990 |
[Different rates of theophylline clearance. A statistical study of a group of asthmatics].
Topics: Asthma; Chronic Disease; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Radioimmunoass | 1990 |
Evaluation of a rapid method for measuring theophylline in a clinical setting.
Topics: Ambulatory Care; Asthma; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; Humans; | 1990 |
[Therapeutic drug monitoring of theophylline].
Topics: Adolescent; Adult; Age Factors; Asthma; Biological Availability; Child; Child, Preschool; Chromatogr | 1990 |
[High-dose inhaled beta-2 sympathomimetics in severe bronchial asthma].
Topics: Administration, Inhalation; Administration, Oral; Albuterol; Asthma; Dose-Response Relationship, Dru | 1990 |
[Comparison of salivary with serum levels of retard theophylline under steady-state conditions].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Male; Sali | 1990 |
[Bioequivalence of theophylline retard capsules in children and relation of metabolism to administration route].
Topics: Adolescent; Asthma; Capsules; Child; Child, Preschool; Delayed-Action Preparations; Humans; Infusion | 1990 |
[The efficacy of theopek in bronchial asthma and chronic bronchitis].
Topics: Adolescent; Adult; Aged; Asthma; Bronchitis; Chronic Disease; Delayed-Action Preparations; Drug Eval | 1990 |
Theophylline pharmacokinetics after intramuscular administration.
Topics: Acute Disease; Administration, Oral; Adult; Asthma; Biological Availability; Bronchitis; Female; Hum | 1990 |
Use of slow-release theophylline in asthma--is it justified?
Topics: Asthma; Delayed-Action Preparations; Humans; Theophylline | 1990 |
[Pharmacokinetics and evaluation of the effectiveness of theopek, a Soviet form of theophylline, in bronchial asthma].
Topics: Adult; Asthma; Drug Evaluation; Humans; Middle Aged; Theophylline | 1990 |
Role of purinergic system in tracheobronchial reactivity of healthy and bronchopathic subjects.
Topics: Adenosine; Adolescent; Adult; Aged; Albuterol; Aminophylline; Asthma; Bronchi; Bronchitis; Bronchodi | 1990 |
Skin reactivity to codeine and histamine during prolonged corticosteroid therapy.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Asthma; Codeine; Female; Histamine; Humans; | 1990 |
Variations in theophylline concentrations detected by 24-hour saliva concentration profiles in ambulatory children with asthma.
Topics: Adolescent; Asthma; Child; Child, Preschool; Citrates; Citric Acid; Delayed-Action Preparations; Dos | 1990 |
[Individualized therapy of protracted attacks of bronchial asthma using theophylline preparations].
Topics: Adult; Asthma; Drug Administration Schedule; Female; Humans; Injections, Intravenous; Male; Middle A | 1990 |
Lack of adverse cardiac effects of combined treatment with theophylline and albuterol in asthmatic children.
Topics: Albuterol; Asthma; Child; Child, Preschool; Electrocardiography, Ambulatory; Exercise Test; Heart; H | 1990 |
Factors related to the nocturnal worsening of asthma.
Topics: Adult; Asthma; Bronchi; Bronchial Provocation Tests; Circadian Rhythm; Female; Forced Expiratory Vol | 1990 |
[Cardiac tolerance of a beta-2-sympathomimetic spray: fenoterol. Apropos of 37 patients followed using a Holter monitor during a brief treatment protocol].
Topics: Adult; Aerosols; Aged; Arrhythmias, Cardiac; Asthma; Cardiac Complexes, Premature; Drug Interactions | 1985 |
[Serum theophylline determination using a radioimmune technic in bronchial asthma patient].
Topics: Adult; Aged; Asthma; Humans; Middle Aged; Radioimmunoassay; Theophylline | 1987 |
[Therapeutic aspects of intractable asthma].
Topics: Adult; Aged; Asthma; Cromolyn Sodium; Female; Humans; Ketotifen; Male; Middle Aged; ortho-Aminobenzo | 1988 |
Pharmacologic modulation of spontaneous histamine release.
Topics: Adult; Alprostadil; Asthma; Basophils; Calcium; Dimaprit; Forced Expiratory Volume; Histamine Releas | 1989 |
[Grand mal series and status using high-dose theophylline medication].
Topics: Adult; Asthma; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clonic; Female; Humans; Middle Aged | 1989 |
Late asthmatic response to allergen challenge (LAR), its clinical feature and pharmacological modulation.
Topics: Albuterol; Allergens; Asthma; Beclomethasone; Bronchial Provocation Tests; Cromolyn Sodium; Humans; | 1989 |
Regarding the article by Furukawa et al.
Topics: Asthma; Child; Cromolyn Sodium; Humans; Learning Disabilities; Mental Disorders; Theophylline | 1989 |
Trichosporon beigelii pneumonia in a neutropenic patient.
Topics: Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Humans; Lung Diseases, Fungal; Mal | 1989 |
[Abrupt change in the clearance of theophylline in children].
Topics: Asthma; Child; Humans; Metabolic Clearance Rate; Theophylline | 1989 |
Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung.
Topics: Adult; Asthma; Autoradiography; Bronchi; Carbachol; Humans; In Vitro Techniques; Iodine Radioisotope | 1989 |
Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients.
Topics: Aged; Asthma; Delayed-Action Preparations; Drug Interactions; Female; Histamine Antagonists; Humans; | 1989 |
Prescribed fenoterol and death from asthma in New Zealand, 1981-83: case-control study.
Topics: Acute Disease; Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Age Factors; | 1989 |
[Respiratory arrest in an asthmatic girl treated with beta-2-mimetics and theophylline. Possible role of hypokalemia in sudden death in asthmatic patients].
Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Child; Death, Sudden; Drug Interactions; Female; Humans | 1989 |
Management of asthma in general practice.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Asthma; Cromolyn Sodium; Engla | 1989 |
[Obstructive bronchitis].
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Airway Obstruction; Asthma; Bronchitis; Child; | 1989 |
Theophylline, beta-adrenergic agents, and calcium channel blockers.
Topics: Adrenergic beta-Antagonists; Asthma; Calcium Channel Blockers; Humans; Theophylline | 1989 |
[Reciprocal actions among anti-asthmatic drugs].
Topics: Asthma; Drug Interactions; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Sympathomime | 1989 |
[Prolonged-action theophylline in the treatment of bronchial asthma].
Topics: Asthma; Delayed-Action Preparations; Drug Evaluation; Humans; Tablets; Theophylline | 1989 |
[Influence of theophylline and corticosteroid preparations on serum PAF acetylhydrolase activity in asthmatic children].
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Asthma; Child, Preschool; Female; Humans; Male; Phos | 1989 |
[Successful treatment with continuous intravenous theophylline therapy at home for a patient with problems of oral theophylline absorption].
Topics: Administration, Oral; Asthma; Home Care Services; Infusion Pumps; Male; Status Asthmaticus; Theophyl | 1989 |
Aminophylline toxicity--how many hospital asthma deaths does it cause?
Topics: Adult; Aged; Aminophylline; Asthma; Cause of Death; Dose-Response Relationship, Drug; Female; Hospit | 1989 |
Theophylline serum levels in children with bronchial asthma after administration of slow release theophylline as open or closed capsules.
Topics: Asthma; Capsules; Child; Delayed-Action Preparations; Humans; Theophylline; Time Factors | 1989 |
[Macrolide-theophylline interaction. Experiences in pediatrics].
Topics: Anti-Bacterial Agents; Asthma; Bayes Theorem; Child; Child, Preschool; Drug Interactions; Erythromyc | 1989 |
[Gastro-esophageal reflux and asthma. Clinical experience].
Topics: Asthma; Child; Clinical Protocols; Female; Gastroesophageal Reflux; Humans; Male; Theophylline | 1989 |
Effects of theophylline in gastroesophageal reflux.
Topics: Asthma; Data Interpretation, Statistical; Gastroesophageal Reflux; Humans; Theophylline | 1989 |
Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children.
Topics: Adolescent; Aging; Asthma; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Ha | 1989 |
[Monitoring serum theophylline levels in children. Use of saliva for prediction].
Topics: Adolescent; Adult; Asthma; Child; Child, Preschool; Female; Humans; Male; Saliva; Theophylline | 1989 |
Management of asthma: a consensus statement.
Topics: Asthma; Child; Child, Preschool; Consensus Development Conferences as Topic; Humans; Theophylline | 1989 |
A protocol for performing reproducible methacholine inhalation tests in children with moderate to severe asthma.
Topics: Adolescent; Asthma; Bronchial Provocation Tests; Child; Forced Expiratory Volume; Humans; Methacholi | 1989 |
Once-daily versus twice-daily dosing of theophylline. A decision analysis approach to evaluating theophylline blood levels and compliance.
Topics: Asthma; Decision Support Techniques; Decision Trees; Drug Administration Schedule; Humans; Patient C | 1989 |
Continuous intravenous therapy with theophylline in patients with brittle bronchial asthma.
Topics: Asthma; Humans; Infusions, Intravenous; Infusions, Parenteral; Terbutaline; Theophylline | 1989 |
Theophylline: Primary or Tertiary Drug? A Brief Review.
Topics: Asthma; Humans; Theophylline | 1989 |
Theophylline-thiabendazole drug interaction.
Topics: Asthma; Delayed-Action Preparations; Drug Interactions; Humans; Male; Middle Aged; Strongyloidiasis; | 1989 |
Psychosocial aspects of compliance in children and adolescents with asthma.
Topics: Adolescent; Asthma; Child; Family Characteristics; Female; Humans; Male; Patient Compliance; Regress | 1989 |
A case of acute psychosis in temporal association with theophylline toxicity.
Topics: Asthma; Child, Preschool; Humans; Male; Psychoses, Substance-Induced; Theophylline | 1989 |
Regarding an article by Milavetz et al.
Topics: Asthma; Biological Availability; Humans; Theophylline | 1989 |
Once nightly sustained release theophylline in elderly subjects.
Topics: Aged; Asthma; Delayed-Action Preparations; Humans; Theophylline | 1989 |
Pharmacokinetic properties of sustained-release theophylline (Theolair-SR) in relation to timing of doses after low-fat meals.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Dietary Fats; Drug Administration Schedule; | 1989 |
The effect of smoking on theophylline kinetics in healthy and asthmatic elderly males.
Topics: Aged; Asthma; Drug Interactions; Humans; Male; Smoking; Theophylline | 1989 |
Effect of theophylline on improvement of the pulmonary function in the treatment of acute episodes of asthma: the influence of the severity of acute asthma.
Topics: Acute Disease; Adult; Airway Resistance; Asthma; Female; Forced Expiratory Volume; Functional Residu | 1989 |
[Pharmacokinetics and chronotherapy of delayed action theophylline (Euphyllin CR)].
Topics: Adolescent; Adult; Asthma; Child; Circadian Rhythm; Delayed-Action Preparations; Drug Administration | 1989 |
Aminophylline dosage in acute severe asthma.
Topics: Aminophylline; Asthma; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; Theoph | 1989 |
Monitoring theophylline levels in serum and saliva using fluorescence polarization immunoassay and Seralyzer.
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Fluorescence Polarization; Humans; Male; Photom | 1989 |
Development of severe Stevens-Johnson syndrome after administration of slow-release theophylline.
Topics: Anti-Bacterial Agents; Asthma; Child; Conjunctivitis; Delayed-Action Preparations; Humans; Male; Pro | 1989 |
[Pharmacokinetics and pharmacodynamics of sustained-release theophylline formulation, Slo-bid, in both single and multiple dosing studies of asthmatic children].
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Female; Humans; Male; Theophylline | 1989 |
[Asthma patients requiring unusually high doses of theophylline].
Topics: Adolescent; Adult; Aged; Asthma; Female; Humans; Male; Middle Aged; Theophylline | 1989 |
T wave inversion associated with severe theophylline toxicity.
Topics: Adult; Arrhythmias, Cardiac; Asthma; Electrocardiography; Female; Heart Conduction System; Humans; T | 1989 |
Are theophylline "levels" a reliable indicator of compliance?
Topics: Administration, Oral; Adolescent; Asthma; Child, Preschool; Female; Humans; Infusions, Intravenous; | 1989 |
Theophylline assay on Kodak Ektachem DTSC--performance and interference by structurally-related compounds and salicylate.
Topics: Alkaline Phosphatase; Asthma; Autoanalysis; Chromatography, High Pressure Liquid; Evaluation Studies | 1989 |
Sustained-release theophylline-uniphyllin in nocturnal asthmatics.
Topics: Adult; Aged; Asthma; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Theophylline | 1989 |
Asthma: a provincial study.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Asthma; Female; Humans | 1989 |
[Levels of blood theophylline in patients with acute bronchospasm].
Topics: Acute Disease; Aged; Asthma; Bronchial Spasm; Delayed-Action Preparations; Female; Humans; Lung Dise | 1989 |
Investigation of a cluster of deaths of adolescents from asthma: evidence implicating inadequate treatment and poor patient adherence with medications.
Topics: Adolescent; Adult; Asthma; Child; Cluster Analysis; Emergencies; Environment; Humans; Patient Compli | 1989 |
Asthma in the very young baby.
Topics: Albuterol; Asthma; Bronchodilator Agents; Child, Preschool; Humans; Infant; Nebulizers and Vaporizer | 1989 |
[Effects of hemosorption on pharmacokinetics of massive doses of theophylline in bronchial asthma].
Topics: Adult; Asthma; Female; Hemoperfusion; Humans; Models, Biological; Theophylline | 1989 |
[Pharmacodynamic effects and dynamics of theophylline concentration in diverse schedules of its dosage].
Topics: Adult; Asthma; Bronchitis; Female; Humans; Male; Middle Aged; Models, Biological; Theophylline; Time | 1989 |
Does theophylline raise serum uric acid concentrations in asthmatic children?
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Infant; Male; Theophylline; Uric Acid | 1989 |
Hypophosphatemia complicating bronchodilator therapy for acute severe asthma.
Topics: Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Child; Female; Humans; Male; Middle Aged; Ph | 1989 |
[Nonlinear theophylline kinetics in a boy on long-term theophylline therapy for bronchial asthma. Case report].
Topics: Adolescent; Asthma; Humans; Male; Theophylline; Time Factors | 1989 |
Once-daily evening administration of Uniphyl tablets: announcement of first available chronotherapy of nocturnal asthma.
Topics: Asthma; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedule; Humans; Theophy | 1989 |
Oral terbutaline alone and in combination with theophylline: dose, plasma concentration, and effect in long-term treatment of bronchial asthma.
Topics: Administration, Oral; Asthma; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Terbutal | 1989 |
Theophylline: is it obsolete for asthma?
Topics: Asthma; Child; Child, Preschool; Drug Administration Schedule; Humans; Infant; Infant, Newborn; Theo | 1989 |
[Asthma and pregnancy].
Topics: Asthma; Female; Humans; Prednisolone; Prednisone; Pregnancy; Pregnancy Complications; Theophylline | 1989 |
Reduced production of oxygen-free radicals of platelets in aspirin-induced-asthma.
Topics: Adult; Aspirin; Asthma; Blood Platelets; Female; Free Radicals; Humans; Male; Methylprednisolone; Ox | 1989 |
Theophylline and school performance.
Topics: Asthma; Child; Child Behavior Disorders; Educational Measurement; Humans; Theophylline | 1989 |
Pharmacological properties of a new antiasthmatic xanthine derivative devoid of central stimulatory activity.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Asthma; Behavior, Animal; Blood Pressure; Bronchodilat | 1987 |
Comprehensive approach to asthma.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Aerosols; Aged; Asthma; Atr | 1985 |
Adequacy of management and severity of asthma in children attending a summer camp.
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Beclomethasone; Bronchodilator Agents; Child; Child, P | 1985 |
Stepwise therapy of bronchial asthma: the role of beta-adrenergic agonists.
Topics: Administration, Oral; Adrenergic beta-Agonists; Aerosols; Asthma; Bronchodilator Agents; Forced Expi | 1985 |
Patterns of drug taking in patients with chronic airflow obstruction.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Bronchitis; Female; Humans; L | 1985 |
Lack of significant arrhythmogenicity from chronic theophylline and beta-2-adrenergic combination therapy in asthmatic subjects.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Arrhythmias, Cardiac; Asthma; Atrial Function; De | 1985 |
[Therapy of status asthmaticus].
Topics: Adrenal Cortex Hormones; Ambroxol; Asthma; Bromhexine; Clorazepate Dipotassium; Histamine H1 Antagon | 1985 |
Exercise-induced asthma. Diagnostic clues with recommendation for treatment.
Topics: Adrenergic beta-Agonists; Asthma; Asthma, Exercise-Induced; Bronchial Spasm; Cromolyn Sodium; Forced | 1985 |
Pulmonary problems of pregnancy.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Asthma; Drug Therapy, Combination; Ethambutol; | 1985 |
Clinical pharmacology of the wheezing infant.
Topics: Adrenergic beta-Agonists; Asthma; Bronchodilator Agents; Humans; Infant; Respiratory Sounds; Respira | 1985 |
Pharmacologic approaches to obstructive airway disease.
Topics: Acute Disease; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Autonomic Nervous S | 1985 |
Theophylline use: an overview.
Topics: Adrenergic beta-Agonists; Age Factors; Asthma; Cromolyn Sodium; Dose-Response Relationship, Drug; Hu | 1985 |
Advantages and disadvantages of 24-hour theophylline.
Topics: Adrenergic beta-Agonists; Adult; Asthma; Child, Preschool; Cromolyn Sodium; Delayed-Action Preparati | 1985 |
Treatment decisions of asthma based on a paradigm of clinical severity.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Allergens; Asthma; Bronchi; Cromolyn Sodium; Forc | 1985 |
The outpatient management of asthma.
Topics: Acupuncture Therapy; Adrenergic beta-Agonists; Aerosols; Ambulatory Care; Asthma; Beclomethasone; Cr | 1985 |
Assessing the efficacy and safety of q. d. theophylline therapy: a multicenter study.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Asthma; Child; Delayed-Action Preparations; Femal | 1985 |
Nocturnal asthma and timing of treatment.
Topics: Adrenergic beta-Antagonists; Airway Resistance; Aminophylline; Asthma; Bronchi; Circadian Rhythm; De | 1985 |
Theophylline levels and clinical response in asthmatic adults receiving long-term Uniphyl.
Topics: Adrenergic beta-Agonists; Adult; Aged; Asthma; Delayed-Action Preparations; Drug Administration Sche | 1985 |
Asthma at night.
Topics: Adrenergic beta-Agonists; Airway Resistance; Asthma; Autonomic Nervous System; Bronchial Provocation | 1985 |
The treatment of asthma. Part 2. Practical aspects of management.
Topics: Acute Disease; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Aerosols; As | 1985 |
New therapeutic approaches in asthma.
Topics: Adrenergic beta-Agonists; Aerosols; Airway Obstruction; Aspirin; Asthma; Bronchi; Bronchodilator Age | 1986 |
[Asthmatic bronchitis].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Diagnosis, Differential; Humans; Infant; | 1986 |
European audit of asthma therapy.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Child; | 1986 |
United States audit of asthma therapy.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Asthma; Child; | 1986 |
Bedside theophylline assay in management of severe acute asthma.
Topics: Acute Disease; Adult; Aminophylline; Asthma; Female; Humans; Immunoassay; Infusions, Intravenous; Th | 1986 |
Modulation of non-specific bronchial reactivity.
Topics: Adrenergic beta-Agonists; Asthma; Asthma, Exercise-Induced; Bronchial Spasm; Cromolyn Sodium; Humans | 1986 |
Bedside theophylline assay in severe acute asthma.
Topics: Acute Disease; Asthma; Humans; Theophylline | 1986 |
New concepts in the management of asthma.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Airway Resistance; Asthma; Atropine; Cromolyn Sod | 1986 |
Drugs for asthma.
Topics: Adrenergic beta-Agonists; Asthma; Cromolyn Sodium; Glucocorticoids; Humans; Ipratropium; Sympathomim | 1987 |
Antiasthmatic drugs--opening remarks.
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Cromolyn Sodium; Humans; Ketotifen; Paras | 1986 |
In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline.
Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Airway Resistance; Asthma; Bronchi; Carbachol; Ch | 1986 |
Treatment of asthma.
Topics: Adrenergic beta-Agonists; Asthma; Breast Feeding; Cromolyn Sodium; Female; Fetal Hypoxia; Glucocorti | 1987 |
[Treatment of acute asthma].
Topics: Adolescent; Adrenergic beta-Agonists; Asthma; Child; Child, Preschool; Humans; Infant; Infant, Newbo | 1987 |
Pharmacologic therapy for bronchial asthma.
Topics: Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adrenergic beta-Agonists; | 1987 |
Aminophylline in acute asthma.
Topics: Adrenergic beta-Agonists; Aminophylline; Asthma; Drug Therapy, Combination; Humans; Theophylline | 1987 |
Therapy for asthma and allergic rhinitis.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Asthma; Child; Child, Preschool; Crom | 1987 |
A report from the Workshop on Pharmacology, Asthma Mortality Task Force.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents | 1987 |
Gastroesophageal reflux and asthma medication.
Topics: Adrenergic beta-Agonists; Adult; Asthma; Female; Gastroesophageal Reflux; Humans; Theophylline | 1987 |
[Progress of therapeutic agents for asthma--1) Progress of anti-asthmatic agents].
Topics: Adrenergic beta-Agonists; Asthma; Beclomethasone; Cromolyn Sodium; Delayed-Action Preparations; Huma | 1987 |
[Treatment of asthma in childhood].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Airway Obstruction; Asthma; Child; Cromolyn Sodiu | 1987 |
Bronchodilators: beta 2 agonists versus theophylline.
Topics: Adrenergic beta-Agonists; Asthma; Chronic Disease; Humans; Theophylline | 1987 |
[Various forms of asthma agents and treatment].
Topics: Adrenergic beta-Agonists; Asthma; Drug Therapy, Combination; Glucocorticoids; Humans; Theophylline | 1987 |
Effect of famotidine on theophylline clearance in asthma and COPD patients.
Topics: Adult; Aged; Asthma; Famotidine; Female; Histamine H2 Antagonists; Humans; Lung Diseases, Obstructiv | 1987 |
[Recommendations for a stepwise plan of long-term drug therapy in obstructive airway diseases].
Topics: Adrenergic beta-Agonists; Adult; Anti-Bacterial Agents; Asthma; Bronchitis; Child; Expectorants; Glu | 1988 |
Increased rate of ethanol elimination and elevated blood acetate in asthmatics on corticosteroid, beta-2-sympathicomimetic and theophylline treatment.
Topics: Acetates; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adult; Age Factors; Alcoholism; Asthma; | 1988 |
Effects of theophylline, beta-adrenergic stimulants and prednisolone on platelet and urine cyclic guanosine monophosphate (cGMP).
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Aminophylline; Asthma; Blood Platelets; Cyclic GMP | 1988 |
Clinical relevance of the interaction of theophylline with diltiazem or nifedipine.
Topics: Adolescent; Adult; Asthma; Diltiazem; Drug Interactions; Drug Therapy, Combination; Humans; Nifedipi | 1989 |
The relationship between theophylline clearance and age in adult life.
Topics: Adult; Aged; Aged, 80 and over; Aging; Asthma; Female; Half-Life; Humans; Male; Metabolic Clearance | 1989 |
Theophylline levels after single daily and divided dosing of a once-a-day theophylline preparation in asthmatic children.
Topics: Adolescent; Asthma; Biological Availability; Child; Circadian Rhythm; Delayed-Action Preparations; F | 1989 |
Effects of time of dose in relation to food on the bioavailability of Theo-Dur Sprinkle at steady state in asthmatic children.
Topics: Asthma; Biological Availability; Child; Child, Preschool; Circadian Rhythm; Delayed-Action Preparati | 1989 |
Effect of in vitro colchicine and oral theophylline on suppressor cell function of asthmatic patients.
Topics: Adolescent; Adult; Asthma; Cells, Cultured; Colchicine; Concanavalin A; Female; Humans; Male; Middle | 1985 |
Effect of theophylline on the proportion and function of T-suppressor cells in asthmatic children.
Topics: Adolescent; Asthma; Child; Child, Preschool; Humans; Rosette Formation; T-Lymphocytes; T-Lymphocytes | 1985 |
Determining optimal therapy--randomized trials in individual patients.
Topics: Aged; Asthma; Clinical Trials as Topic; Double-Blind Method; Ethics, Medical; Humans; Ipratropium; M | 1986 |
[Hypercapnic status asthmaticus. Rapid reversibility of hypercapnia under medical treatment].
Topics: Adolescent; Adult; Aged; Asthma; Emergencies; Female; Humans; Hydrocortisone; Hypercapnia; Male; Mid | 1986 |
Theophylline-induced alterations in cellular immunity in asthmatic patients.
Topics: Adolescent; Adult; Asthma; Female; Graft vs Host Reaction; Humans; Immunity, Cellular; Male; Middle | 1987 |
Home nebulizers in childhood asthma. Parental perceptions and practices.
Topics: Adolescent; Albuterol; Asthma; Child; Child, Preschool; Cromolyn Sodium; Female; Hospitalization; Hu | 1988 |
Cellular immunity and suppressor T cell function in asthmatic children on prolonged theophylline therapy.
Topics: Asthma; Child; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Male; Reference Values; Ro | 1988 |
On the mechanism of action of theophylline and caffeine.
Topics: Adenosine; Asthma; Caffeine; Calcium; Cyclic AMP; Humans; Muscle Contraction; Receptors, Cell Surfac | 1985 |
Actions of bronchodilator drugs, glucocorticoid, and their combinations on airways in rats and guinea pigs.
Topics: Animals; Asthma; Bronchodilator Agents; Disease Models, Animal; Drug Interactions; Female; Glucocort | 1985 |
The mast cell and theophylline in asthma.
Topics: Adenosine Triphosphate; Asthma; Chemotactic Factors; Chondroitin Sulfates; Cyclic AMP; Heparin; Hist | 1985 |
[Behavior of the second messenger cAMP in status asthmaticus before and following administration of theophylline-ethylenediamine].
Topics: Adult; Aminophylline; Anthracenes; Asthma; Cyclic AMP; Electrocardiography; Female; Humans; Male; Mi | 1985 |
Influence of the epithelium on responsiveness of guinea-pig isolated trachea to contractile and relaxant agonists.
Topics: Acetylcholine; Animals; Asthma; Autoradiography; Carbachol; Cimetidine; Colforsin; Dose-Response Rel | 1986 |
Pharmacodynamics (lung function tests, tremor measurements and cAMP determinations) of a single dose of 0.5 mg terbutaline subcutaneously during sustained-release theophylline medication in patients with asthmatic bronchitis.
Topics: Adult; Asthma; Bronchitis; Cyclic AMP; Delayed-Action Preparations; Drug Interactions; Female; Human | 1986 |
Maintenance theophylline therapy in children: effect on urinary calcium, phosphate and cyclic AMP excretion.
Topics: Adolescent; Asthma; Calcium; Child; Child, Preschool; Cyclic AMP; Delayed-Action Preparations; Femal | 1987 |
[Respiratory disease and clinical pharmacology--serum concentration and pharmacological effect of beta-stimulant and theophylline].
Topics: Adult; Asthma; Female; Humans; Kinetics; Male; Middle Aged; Receptors, Adrenergic, beta; Terbutaline | 1987 |
[Efficacy of whole blood theophylline assay kit AccuLevel].
Topics: Asthma; Child, Preschool; Evaluation Studies as Topic; Humans; Immunoenzyme Techniques; Male; Reagen | 1988 |
Interaction between carbamazepine and theophylline.
Topics: Asthma; Carbamazepine; Child; Drug Interactions; Epilepsy, Tonic-Clonic; Female; Half-Life; Humans; | 1986 |
[Theophylline in asthma therapy].
Topics: Asthma; Humans; Long-Term Care; Lung Diseases, Obstructive; Theophylline | 1986 |
Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis.
Topics: Albuterol; Asthma; Cromolyn Sodium; Humans; Hypersensitivity; Injections, Intravenous; Ketotifen; Lu | 1986 |
Pathogenesis of exercise-induced asthma: implications for treatment.
Topics: Asthma; Asthma, Exercise-Induced; Cromolyn Sodium; Humans; Physical Exertion; Sports; Theophylline | 1986 |
Prevention with and without the use of medications for exercise-induced asthma.
Topics: Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Carbon Dioxide; Child; Cromolyn Sodium; Hum | 1986 |
Crying-induced bronchospasm in childhood asthma: response to nebulized metaproterenol 5% and sodium cromoglycate 1%.
Topics: Administration, Oral; Aerosols; Asthma; Child, Preschool; Cromolyn Sodium; Crying; Humans; Metaprote | 1986 |
Management of asthma. A Canadian perspective.
Topics: Acute Disease; Adrenal Cortex Hormones; Asthma; Canada; Child; Combined Modality Therapy; Cromolyn S | 1986 |
Asthma mortality: comparison between New Zealand and England.
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Emergency Medical Services; England; Female; Gluco | 1986 |
The use of theophylline clearance in pediatric status asthmaticus. II. The choice of appropriate dose for the intravenous theophylline infusion.
Topics: Administration, Oral; Asthma; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; Inf | 1987 |
Cromolyn sodium for childhood asthma: a drug whose time has come.
Topics: Asthma; Child; Cromolyn Sodium; Humans; Theophylline | 1987 |
Pharmacologic management of asthma.
Topics: Adolescent; Adrenal Cortex Hormones; Asthma; Autonomic Agents; Child; Cromolyn Sodium; Female; Human | 1987 |
Myocardial ischemia complicating therapy of status asthmaticus.
Topics: Asthma; Child; Coronary Disease; Electrocardiography; Humans; Infusions, Intravenous; Isoproterenol; | 1987 |
Fatal asthma--is treatment incriminated?
Topics: Adrenal Cortex Hormones; Aerosols; Animals; Asthma; Bronchodilator Agents; Dogs; Drug Therapy, Combi | 1987 |
Effect of drugs used in the treatment of asthma on the production of eosinophil-activating factor by monocytes.
Topics: Albuterol; Asthma; Beclomethasone; Cromolyn Sodium; Eosinophils; Humans; Lymphokines; Methylpredniso | 1988 |
Theophylline--use and misuse in pediatric asthma.
Topics: Asthma; Child; Humans; Theophylline | 1988 |
Effect of single dose intravenous aminophylline in asthma.
Topics: Adolescent; Aminophylline; Asthma; Child; Female; Humans; Injections, Intravenous; Male; Theophyllin | 1987 |
Effect of body weight on the volume of distribution of theophylline.
Topics: Adult; Aged; Asthma; Body Weight; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Age | 1988 |
[Effect of the diagnosis and prevention of exercise-induced bronchial obstruction on sports participation by asthmatic school children].
Topics: Airway Resistance; Albuterol; Asthma; Asthma, Exercise-Induced; Beclomethasone; Child; Cromolyn Sodi | 1988 |
Modulation of T-cell subsets in asthmatic children by THF, a thymic hormone.
Topics: Adolescent; Animals; Asthma; Child; Child, Preschool; Female; Graft vs Host Reaction; Humans; Leukoc | 1985 |
Continuous intravenous therapy with theophylline in a patient with brittle bronchial asthma.
Topics: Activities of Daily Living; Adult; Asthma; Female; Humans; Infusion Pumps; Peak Expiratory Flow Rate | 1988 |
Comparison of a new sustained-release theophylline preparation, TheoBeads, with Theo-Dur tablets in children with asthma.
Topics: Asthma; Capsules; Child; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; | 1988 |
Prophylaxis for asthma.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Asthma; Humans; Theophylline | 1988 |
Prediction of intravenous theophylline dosage based on a single, nonsteady-state concentration: a clinical study of childhood status asthmaticus.
Topics: Asthma; Child; Humans; Infusions, Intravenous; Status Asthmaticus; Theophylline | 1988 |
Generic substitution: a dilemma for the allergist.
Topics: Allergy and Immunology; Asthma; Humans; Patient Education as Topic; Physician-Patient Relations; The | 1988 |
[Slow-release theophyllines: serum and saliva levels in asthmatic children].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Humans; Saliva; Theophylli | 1988 |
[Chronopharmacokinetics of theophylline].
Topics: Adolescent; Asthma; Child; Circadian Rhythm; Female; Humans; Male; Theophylline | 1988 |
Influence of theophylline on gastro-oesophageal reflux and asthma.
Topics: Asthma; Female; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Resp | 1988 |
Is posture clinically important when monitoring theophylline therapy?
Topics: Adult; Aged; Asthma; Female; Forced Expiratory Volume; Humans; Male; Middle Aged; Posture; Theophyll | 1988 |
[Anxiety crisis (panic attack) secondary to the administration of theophylline in an oral sustained-release preparation].
Topics: Administration, Oral; Adult; Anxiety Disorders; Asthma; Delayed-Action Preparations; Fear; Female; H | 1988 |
[Effect of azelastine on theophylline clearance in asthma patients].
Topics: Administration, Oral; Adult; Aged; Asthma; Delayed-Action Preparations; Female; Humans; Male; Metabo | 1988 |
Serum theophylline testing in a pediatric emergency setting: potential benefit of rapid assays.
Topics: Asthma; Child; Child, Preschool; Drug Administration Schedule; Emergency Service, Hospital; Hospital | 1988 |
Acceptance of domiciliary theophylline monitoring using dried blood spots.
Topics: Adolescent; Asthma; Blood Specimen Collection; Child; Child, Preschool; Delayed-Action Preparations; | 1988 |
[Determinations of blood theophylline level in a severe asthma attack in childhood treated with respirator therapy].
Topics: Adolescent; Aminophylline; Asthma; Combined Modality Therapy; Dose-Response Relationship, Drug; Emer | 1988 |
[Clinical evaluation of intravenous theophylline therapy in status asthmaticus].
Topics: Adult; Aged; Asthma; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Status Asthmaticus; | 1988 |
[Theophyllines and their derivatives].
Topics: Asthma; Humans; Theophylline | 1988 |
[The first retard theophylline made in Czechoslovakia for the treatment of asthma in children--Spophyllin Spofa].
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Humans; Theophylline | 1988 |
[Changes in theophylline levels in the blood serum and saliva of children with bronchial asthma].
Topics: Adolescent; Asthma; Biological Availability; Child; Humans; Saliva; Theophylline; Time Factors | 1988 |
[How to determine theophylline dosage?].
Topics: Administration, Oral; Adult; Age Factors; Asthma; Bronchi; Child; Child, Preschool; Humans; Infant; | 1988 |
The consistency of theophylline absorption from a sustained-release formulation in asthmatic children.
Topics: Administration, Oral; Analysis of Variance; Asthma; Child; Child, Preschool; Circadian Rhythm; Delay | 1988 |
Case management and quality assurance to improve care of inner-city children with asthma.
Topics: Asthma; Child, Preschool; Emergencies; Female; Home Nursing; Humans; Infant; Male; Medicaid; Parents | 1988 |
Impact of AccuLevel on treatment of acute asthma.
Topics: Acute Disease; Asthma; Blood Chemical Analysis; Emergency Medical Services; Hospitalization; Humans; | 1988 |
[Chronotherapy and allergic diseases].
Topics: Asthma; Chronobiology Phenomena; Circadian Rhythm; Drug Administration Schedule; Humans; Kinetics; P | 1987 |
Whole blood assay of theophylline concentrations using immunochromatographic stick at the bedside.
Topics: Adolescent; Asthma; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Immunoenz | 1987 |
Theophylline has a dose-related effect on the airway response to inhaled histamine and methacholine in asthmatics.
Topics: Adolescent; Adult; Airway Resistance; Asthma; Bronchi; Bronchial Provocation Tests; Dose-Response Re | 1987 |
Nonprescription availability of antiasthma drugs.
Topics: Adult; Asthma; Canada; Child; Child, Preschool; Female; Humans; Infant; Nonprescription Drugs; Pregn | 1988 |
Bioavailability of a slow-release theophylline capsule given twice daily to preschool children with chronic asthma: comparison with liquid theophylline.
Topics: Asthma; Biological Availability; Child, Preschool; Chronic Disease; Delayed-Action Preparations; Dru | 1988 |
[The treatment of asthma in childhood].
Topics: Asthma; Child; Humans; Parasympatholytics; Theophylline; Tropanes | 1988 |
The pharmacokinetics and efficacy of slow-release theophylline with asymmetric dosing in asthmatic Chinese.
Topics: Adult; Asthma; Bronchodilator Agents; China; Choline; Delayed-Action Preparations; Drug Administrati | 1988 |
Childhood asthma: prevention of attacks with short-term corticosteroid treatment of upper respiratory tract infection.
Topics: Albuterol; Asthma; Child, Preschool; Drug Therapy, Combination; Female; Humans; Male; Metaproterenol | 1988 |
Diet-induced changes in trough theophylline concentrations in an elderly asthmatic patient.
Topics: Aged; Asthma; Diet, Reducing; Humans; Male; Obesity; Theophylline | 1988 |
Theophylline serum levels unmodified by postprandial administration of a sustained-release preparation (Teonova).
Topics: Aged; Asthma; Delayed-Action Preparations; Humans; Male; Middle Aged; Theophylline | 1988 |
Clinical experience with theophylline. A case for monitoring serum concentrations.
Topics: Adult; Asthma; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Theophylline; Time Factor | 1988 |
[Chronokinetic study of various delayed-release theophyllines in children].
Topics: Asthma; Child; Chromatography, Liquid; Circadian Rhythm; Delayed-Action Preparations; Humans; Theoph | 1988 |
Vitamin B6 nutritional status in asthma: the effect of theophylline therapy on plasma pyridoxal-5'-phosphate and pyridoxal levels.
Topics: Adolescent; Adult; Aged; Asthma; Female; Humans; Middle Aged; Nutritional Physiological Phenomena; P | 1988 |
Evaluation of an office method of measuring theophylline serum concentrations.
Topics: Asthma; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Evaluation Studies | 1988 |
Enhancement of theophylline clearance by intravenous albuterol.
Topics: Albuterol; Asthma; Drug Interactions; Humans; Infant; Infusions, Intravenous; Male; Metabolic Cleara | 1988 |
How much theophylline is enough?
Topics: Asthma; Bronchi; Circadian Rhythm; Humans; Theophylline | 1988 |
Review of the North American experience with evening administration of Uniphyl tablets, a once-daily theophylline preparation, in the treatment of nocturnal asthma.
Topics: Adult; Asthma; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedule; Food; Hu | 1988 |
Cardiac arrest associated with halothane anesthesia in a patient receiving theophylline.
Topics: Anesthesia; Asthma; Child; Drug Interactions; Female; Halothane; Heart Arrest; Humans; Theophylline | 1988 |
Mechanism of action of methylxanthines in asthma.
Topics: Aminophylline; Asthma; Biomechanical Phenomena; Calcium; Child; Child, Preschool; Epinephrine; Human | 1988 |
Plasma catecholamine concentrations during a 72-hour aminophylline infusion in children with acute asthma.
Topics: Acute Disease; Administration, Inhalation; Albuterol; Aminophylline; Asthma; Child; Drug Therapy, Co | 1988 |
Cardiac arrhythmias during the combined use of intravenous aminophylline and terbutaline in status asthmaticus.
Topics: Adult; Aged; Aminophylline; Arrhythmias, Cardiac; Asthma; Drug Therapy, Combination; Electrocardiogr | 1988 |
Once daily Theo-Dur in morning dippers.
Topics: Adult; Asthma; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Peak Expiratory Flow | 1988 |
Effect of peak flow information on patterns of self-care in adult asthma.
Topics: Adaptation, Psychological; Adult; Asthma; Bronchodilator Agents; Female; Humans; Male; Peak Expirato | 1988 |
[Diagnosis and therapy of nocturnal asthma].
Topics: Airway Resistance; Asthma; Circadian Rhythm; Delayed-Action Preparations; Dose-Response Relationship | 1987 |
Determinants of free theophylline clearance in asthma.
Topics: Adult; Aged; Asthma; Body Weight; Female; Humans; Male; Middle Aged; Theophylline; Thyroid Hormones | 1987 |
[Monitoring of three delayed-release preparations of theophylline in the plasma of children: pharmacokinetic parameters and therapeutic significance].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Evaluation; Half-Life | 1987 |
Nonprescription availability of theophylline, epinephrine and ephedrine for asthma.
Topics: Asthma; Canada; Ephedrine; Epinephrine; Humans; Nonprescription Drugs; Theophylline | 1987 |
Pharmacokinetics of oral theophylline in Thai asthmatic children.
Topics: Administration, Oral; Adolescent; Asthma; Body Weight; Child; Ethnicity; Half-Life; Humans; Solution | 1987 |
[The usefulness of measuring the saliva theophylline concentration].
Topics: Adult; Aged; Asthma; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Monitoring, Phy | 1987 |
[Intravenous theophylline in the treatment of asthma attacks].
Topics: Asthma; Dose-Response Relationship, Drug; Humans; Injections, Intravenous; Theophylline | 1987 |
An improved protocol for the use of troleandomycin (TAO) in the treatment of steroid-requiring asthma.
Topics: Adult; Aged; Asthma; Bronchospirometry; Drug Administration Schedule; Female; Follow-Up Studies; Hum | 1986 |
Effect of miocamycin on theophylline kinetics in children.
Topics: Asthma; Child; Chronic Disease; Drug Interactions; Female; Half-Life; Humans; Kinetics; Leucomycins; | 1987 |
Office measurement of serum theophylline.
Topics: Asthma; Child; Humans; Reagent Kits, Diagnostic; Theophylline | 1987 |
Evaluation of a sustained-release theophylline product in children with asthma.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Administration Schedule; Drug Eva | 1987 |
Saliva and serum theophylline concentration in management of asthma in children on sustained-release therapy.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Forced Expiratory Volume; Humans; Lung; Maxi | 1987 |
Effect of miocamycin on theophylline kinetics in asthmatic children.
Topics: Asthma; Child; Drug Interactions; Half-Life; Humans; Leucomycins; Metabolic Clearance Rate; Miocamyc | 1987 |
A rapid method of theophylline assay in the physician's office.
Topics: Asthma; Chromatography, High Pressure Liquid; Fluorescent Antibody Technique; Humans; Theophylline | 1986 |
Efficacy of maintenance of therapeutic serum concentrations of theophylline in chronic asthma.
Topics: Adult; Aged; Aged, 80 and over; Asthma; Female; Humans; Kinetics; Male; Middle Aged; Respiratory Fun | 1987 |
[Treatment of bronchial asthma: a plea for bronchodilators via inhalation].
Topics: Administration, Inhalation; Aerosols; Asthma; Bronchodilator Agents; Sympathomimetics; Tachyphylaxis | 1987 |
Incidence of apparent Michaelis-Menten kinetic behavior of theophylline and its parameters (Vmax and Km) among asthmatic children and adults.
Topics: Adolescent; Adult; Age Factors; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Humans | 1987 |
[Theophylline pharmacokinetics in elderly persons and in patients with bronchial asthma or chronic obstructive bronchitis].
Topics: Aged; Asthma; Bronchitis; Chronic Disease; Humans; Kinetics; Male; Middle Aged; Theophylline | 1986 |
Problems with generic theophylline and indiscriminate brand switching.
Topics: Asthma; Bronchial Spasm; Dose-Response Relationship, Drug; Half-Life; Humans; Kinetics; Theophylline | 1987 |
[Effectiveness and tolerance of the treatment of infantile bronchial asthma with soluble and delayed-action theophylline].
Topics: Asthma; Child; Delayed-Action Preparations; Female; Humans; Male; Respiratory Function Tests; Theoph | 1987 |
Absorption characteristics of once-a-day slow-release theophylline preparation in children with asthma.
Topics: Absorption; Adolescent; Asthma; Biological Availability; Child; Delayed-Action Preparations; Dose-Re | 1987 |
A new simplified assay for the quantitation of theophylline and its major metabolites in urine by high-performance liquid chromatography.
Topics: Asthma; Biotransformation; Chromatography, High Pressure Liquid; Humans; Theophylline | 1987 |
[Clinical effects of theophylline in the therapy of intractable asthmatic children. I. Clinical effects of a new sustained-release preparation of theophylline E-0686].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Evaluation; Female; H | 1987 |
Longitudinal effects of pregnancy on the pharmacokinetics of theophylline.
Topics: Asthma; Blood Proteins; Female; Humans; Kinetics; Metabolic Clearance Rate; Milk, Human; Pregnancy; | 1987 |
Ketoconazole--theophylline interaction.
Topics: Asthma; Drug Interactions; Humans; Ketoconazole; Male; Middle Aged; Mycoses; Theophylline | 1987 |
Intraindividual variability in theophylline pharmacokinetics in subjects with mild/moderate asthma.
Topics: Adult; Asthma; Humans; Individuality; Kinetics; Male; Theophylline | 1987 |
[Delayed-action theophylline in the treatment children with chronic asthma. Results of our experience].
Topics: Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Delayed-Action Preparations; Female; H | 1987 |
[Results of a trial with a sustained-release preparation of theophylline (1/24 hour) in childhood asthmatics].
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Dietary Carbohydrates; Dietary Proteins; Fem | 1987 |
[Theophylline in bronchial asthma--clinical effect and mechanism of action].
Topics: Airway Resistance; Asthma; Bronchi; Humans; Theophylline | 1987 |
[Therapeutic non-compliance in patients with chronic airway obstruction].
Topics: Adult; Aged; Aminophylline; Asthma; Female; Humans; Lung Diseases, Obstructive; Male; Medication Err | 1987 |
[Diagnostic and therapeutic use of saliva examination in children].
Topics: Acute Disease; Asthma; Child, Preschool; Humans; Immunoglobulin A, Secretory; Infant; Isoenzymes; L- | 1987 |
Using a hand-held spirometer as a monitoring tool in chronic theophylline therapy.
Topics: Adult; Asthma; Child; Female; Forced Expiratory Volume; Humans; Lung Diseases, Obstructive; Male; Mi | 1987 |
Regarding the article, "Comparison study of sustained-release theophylline products: Slo-bid capsules versus Theo-Dur tablets in 20 children and young adults with asthma".
Topics: Adolescent; Adult; Asthma; Capsules; Child; Delayed-Action Preparations; Drug Evaluation; Humans; Ta | 1987 |
[Theophylline overdoses on admission to a resuscitation unit].
Topics: Acute Disease; Aged; Asthma; Emergency Service, Hospital; Female; Humans; Lung Diseases, Obstructive | 1987 |
[Asthma and pregnancy: peculiarities, therapeutic precautions].
Topics: Adrenal Cortex Hormones; Asthma; Breast Feeding; Female; Humans; Labor, Obstetric; Pregnancy; Pregna | 1987 |
Clinical relevance of theophylline chronokinetics for asthmatic children.
Topics: Adolescent; Asthma; Child; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedu | 1987 |
[Asthma during pregnancy].
Topics: Adrenal Cortex Hormones; Aminophylline; Asthma; Atropine Derivatives; Female; Humans; Labor, Obstetr | 1987 |
Theophylline dosing frequency: principles and practices.
Topics: Asthma; Delayed-Action Preparations; Drug Administration Schedule; Humans; Middle Aged; Theophylline | 1987 |
[Status asthmaticus].
Topics: Asthma; Combined Modality Therapy; Emergencies; Epinephrine; Humans; Injections, Intravenous; Oxygen | 1986 |
[Bronchial asthma].
Topics: Adult; Asthma; Child; Humans; Immunotherapy; Occupational Diseases; Oxygen Inhalation Therapy; Statu | 1986 |
Theophylline usage in patients with acute asthma presenting to a central hospital.
Topics: Acute Disease; Asthma; Drug Combinations; Emergency Service, Hospital; Ephedrine; Humans; Theophylli | 1986 |
Theophylline activity in late asthmatic response.
Topics: Asthma; Humans; Theophylline | 1987 |
Post-mortem concentrations of salbutamol, terbutaline and theophylline in asthma patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Albuterol; Animals; Asthma; Female; Human | 1987 |
Pharmacokinetics of theophylline in Chinese asthmatics.
Topics: Adult; Asian People; Asthma; Humans; Male; Metabolic Clearance Rate; Middle Aged; Smoking; Taiwan; T | 1987 |
Effect of theophylline on insulin-like growth factor I in children with asthma.
Topics: Asthma; Child; Child, Preschool; Female; Humans; Insulin-Like Growth Factor I; Male; Prolactin; Soma | 1987 |
Evaluation of the effectiveness and safety of a controlled-release theophylline in patients with reversible and stable bronchial obstruction.
Topics: Adult; Asthma; Delayed-Action Preparations; Female; Humans; Lung; Lung Diseases, Obstructive; Male; | 1987 |
[Slow-release theophylline in recurrent bronchial asthma. Clearance of the drug and circadian variations in blood theophylline].
Topics: Adolescent; Asthma; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Male; Metabolic Clear | 1987 |
[Clinical relevance of monitoring the plasma levels of theophylline].
Topics: Adult; Asthma; Child; Humans; Monitoring, Physiologic; Theophylline | 1987 |
Theophylline absorption from two sustained-release products. Implications for therapeutic drug monitoring.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Biological Availability; Child; Delayed-Action Prep | 1987 |
Circadian rhythm-adapted theophylline schedules for asthma.
Topics: Asthma; Circadian Rhythm; Drug Administration Schedule; Humans; Theophylline | 1987 |
Steady state pharmacokinetics, metabolism and pharmacodynamics of theophylline in children after unequal twice-daily dosing of a new sustained-release formulation.
Topics: Asthma; Child; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Schedule; Female; | 1987 |
Monitoring theophylline therapy using citric acid-stimulated saliva in infants and children with asthma.
Topics: Adolescent; Asthma; Child; Child, Preschool; Citrates; Citric Acid; Humans; Infant; Monitoring, Phys | 1987 |
High theophyllin doses required for asthma control.
Topics: Asthma; Humans; Theophylline | 1987 |
The use of a single daily theophylline dose and metered-dose albuterol in asthma treatment.
Topics: Albuterol; Asthma; Drug Administration Schedule; Humans; Theophylline | 1987 |
[Changes in plasma levels of theophylline in therapeutic combination with cimetidine and ranitidine].
Topics: Adult; Asthma; Cimetidine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middl | 1986 |
[Non-lineal kinetic behavior of theophylline. Apropos of a case].
Topics: Adult; Asthma; Humans; Kinetics; Male; Theophylline | 1986 |
[Clinical experience with bamifylline in children with asthmatic bronchitis or bronchial asthma].
Topics: Asthma; Bronchitis; Bronchodilator Agents; Child; Child, Preschool; Drug Evaluation; Female; Humans; | 1986 |
Intraindividual changes in theophylline clearance during constant aminophylline infusion in children with acute asthma.
Topics: Acute Disease; Aminophylline; Asthma; Child; Child, Preschool; Female; Humans; Infusions, Parenteral | 1986 |
Large theophylline requirements due to high theophylline clearance: verification by the antipyrine test.
Topics: Adult; Antipyrine; Asthma; Half-Life; Humans; Kinetics; Liver; Male; Theophylline | 1986 |
Mode of administration of sustained-release tablets.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Humans; Patient Compliance; Theophylli | 1986 |
Accuracy of 11 methods for predicting theophylline dose.
Topics: Acute Disease; Adult; Asthma; Bronchial Spasm; Female; Humans; Kinetics; Male; Metabolic Clearance R | 1986 |
Circadian variation in steady-state trough theophylline concentrations.
Topics: Adult; Asthma; Circadian Rhythm; Humans; Specimen Handling; Theophylline; Time Factors | 1986 |
Clinical evaluation of a dry chemistry strip theophylline assay.
Topics: Adult; Asthma; Child; Costs and Cost Analysis; Flavin-Adenine Dinucleotide; Fluorescence Polarizatio | 1986 |
Timing of once-a-day theophylline dose to match peak blood level with diurnal variation in severity of asthma.
Topics: Asthma; Circadian Rhythm; Drug Administration Schedule; Humans; Metabolic Clearance Rate; Theophylli | 1986 |
[The effect of histamine and theophylline and the formation of E rosettes].
Topics: Asthma; Histamine; Humans; Melanoma; Rhinitis, Allergic, Seasonal; Rosette Formation; Theophylline | 1986 |
Circadian changes in the absorption and elimination of theophylline in patients with bronchial obstruction.
Topics: Absorption; Aged; Aminophylline; Asthma; Circadian Rhythm; Delayed-Action Preparations; Female; Huma | 1986 |
Early estimate of theophylline clearance during intravenous infusion.
Topics: Acute Disease; Adult; Aged; Aminophylline; Asthma; Female; Humans; Infusions, Parenteral; Kinetics; | 1986 |
Rational theophylline use in older asthmatics.
Topics: Absorption; Aged; Aging; Anti-Bacterial Agents; Asthma; Drug Interactions; Female; Humans; Kinetics; | 1986 |
Evaluation of a scheme for establishing and maintaining dosage of theophylline in ambulatory patients with chronic asthma.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Asthma; Child; Child, Preschool; Drug Administration Sched | 1986 |
[Use and abuse of bronchodilators].
Topics: Asthma; Bronchodilator Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Epine | 1986 |
Incidence of preeclampsia among asthmatic patients lower with theophylline.
Topics: Adult; Asthma; Female; Humans; Platelet Aggregation; Pre-Eclampsia; Pregnancy; Theophylline; Vascula | 1986 |
[Guidelines for determination of the optimum dosage of E-0686. A new sustained-release preparation of theophylline].
Topics: Adolescent; Adult; Age Factors; Aged; Asthma; Body Weight; Child; Child, Preschool; Delayed-Action P | 1986 |
Theophylline pharmacokinetics in pregnancy.
Topics: Asthma; Blood Proteins; Female; Humans; Kinetics; Mathematics; Pregnancy; Pregnancy Complications; P | 1986 |
Spiramycin has no effect on serum theophylline in asthmatic patients.
Topics: Adult; Aged; Asthma; Delayed-Action Preparations; Drug Interactions; Female; Humans; Kinetics; Leuco | 1986 |
[Theophylline solubilizer and salicylate asthma].
Topics: Asthma; Drug Hypersensitivity; Humans; Pharmaceutical Vehicles; Salicylamides; Salicylates; Theophyl | 1986 |
Once-a-day sustained-release theophylline: a clinical experience.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Humans; Theophylline | 1986 |
Medication compliance in children with asthma.
Topics: Adolescent; Asthma; Child; Humans; Internal-External Control; Patient Compliance; Self Concept; Theo | 1986 |
Theophylline clearance during pregnancy.
Topics: Adolescent; Adult; Asthma; Body Weight; Female; Humans; Kinetics; Postpartum Period; Pregnancy; Preg | 1986 |
[Serum levels and bronchodilatation after intravenous administration of theophylline in asthmatic patients].
Topics: Adult; Aged; Asthma; Bronchi; Female; Forced Expiratory Volume; Humans; Infusions, Parenteral; Kinet | 1986 |
High theophylline doses required for asthma control.
Topics: Adult; Asthma; Dose-Response Relationship, Drug; Female; Humans; Prednisone; Theophylline | 1986 |
Studies on the pharmacokinetics of theophylline and its effect on respiratory impedance in asthmatic patients after multiple oral dosing of a sustained-release theophylline tablet formulation.
Topics: Administration, Oral; Adult; Aged; Asthma; Delayed-Action Preparations; Female; Humans; Kinetics; Ma | 1986 |
Bioavailability of a once daily-administered theophylline preparation. A comparison study.
Topics: Administration, Oral; Asthma; Biological Availability; Delayed-Action Preparations; Drug Administrat | 1986 |
Conversion from intravenous to sustained-release oral theophylline in pediatric patients with asthma.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Female; Humans; Injections, Intravenous; Kin | 1986 |
Individualization of theophylline dosage in adults with bronchial asthma.
Topics: Adult; Asthma; Female; Humans; Kinetics; Male; Middle Aged; Theophylline | 1986 |
[Fetal bigeminus following combined bronchodilator treatment of the mother].
Topics: Arrhythmias, Cardiac; Asthma; Drug Therapy, Combination; Electrocardiography; Female; Fetal Diseases | 1986 |
Plasma theophylline concentrations in asthmatic children receiving a twice daily theophylline preparation.
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Male; Theo | 1986 |
Acute and chronic pharmacokinetics of asymmetrical doses of slow release choline theophyllinate in asthma.
Topics: Administration, Oral; Aged; Asthma; Blood Stains; Bronchodilator Agents; Choline; Delayed-Action Pre | 1986 |
Steady-state pharmacokinetics and effects of a new once-daily, slow-release theophylline capsule preparation in asthma.
Topics: Adult; Aged; Asthma; Delayed-Action Preparations; Female; Forced Expiratory Volume; Humans; Kinetics | 1986 |
The Contin delivery system: dosing considerations.
Topics: Asthma; Delayed-Action Preparations; Drug Administration Schedule; Humans; Tablets; Theophylline | 1986 |
[Evaluation of circadian variation in serum theophylline levels in the sustained-release theophylline treatment of chronic asthma].
Topics: Adult; Aged; Asthma; Chronic Disease; Circadian Rhythm; Delayed-Action Preparations; Female; Humans; | 1986 |
Pharmacokinetics of theophylline in beagle dogs and asthmatic patients after multiple oral doses of sustained-release theophylline tablet formulation.
Topics: Administration, Oral; Adult; Aged; Animals; Asthma; Blood Proteins; Delayed-Action Preparations; Dog | 1986 |
Effects of histamine and reproterol inhalation on mouth occlusion pressure in patients with bronchial asthma.
Topics: Adult; Asthma; Autonomic Nervous System; Bronchial Provocation Tests; Bronchodilator Agents; Drug Co | 1986 |
[Reasons for the ineffectiveness of the treatment of bronchial asthma in children with theophylline preparations].
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Infant; Male; Theophylline | 1986 |
A 15-year-old girl with a perforated gastric ulcer.
Topics: Adolescent; Asthma; Cimetidine; Female; Humans; Peptic Ulcer Perforation; Stomach Ulcer; Theophyllin | 1986 |
Current state of theophylline in asthma.
Topics: Asthma; Child; Humans; Theophylline | 1986 |
The pharmacokinetics of uniphyllin in nocturnal asthma.
Topics: Acute Disease; Adult; Asthma; Circadian Rhythm; Delayed-Action Preparations; Drug Administration Sch | 1986 |
[Preliminary results of a new delayed-action theophylline preparation (1 dose in 24 hours) in the treatment of childhood asthma].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Administration Schedu | 1986 |
Comparison of once-a-day and twice-a-day theophylline in asthma.
Topics: Asthma; Delayed-Action Preparations; Drug Administration Schedule; Evaluation Studies as Topic; Forc | 1986 |
Clinical predictors of theophylline blood levels in asthmatic patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Delayed-Action Preparations; Emergency Medical S | 1987 |
Sustained release theophylline and ephedrine therapy in chronic asthma.
Topics: Adolescent; Adult; Asthma; Child; Chronic Disease; Delayed-Action Preparations; Drug Combinations; E | 1986 |
Changes in theophylline clearance during aminophylline infusion.
Topics: Asthma; Child; Humans; Theophylline | 1987 |
[Value of a daily dose of theophylline in the treatment of nocturnal asthma].
Topics: Adult; Asthma; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Theophylline | 1986 |
The use of theophylline clearance in pediatric status asthmaticus. I. Interpatient and intrapatient theophylline clearance variability.
Topics: Acute Disease; Asthma; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Individuality; In | 1987 |
Reliability and predictive value of salivary theophylline levels.
Topics: Adolescent; Adult; Aminophylline; Asthma; Child; Female; Humans; Kinetics; Male; Middle Aged; Monito | 1987 |
Theophylline loading in acute asthma.
Topics: Adult; Asthma; Epinephrine; Female; Humans; Male; Theophylline | 1987 |
Studies on the absorption kinetics of theophylline in the steady state, following multiple oral dosing of a sustained-release theophylline tablet formation to asthmatic patients.
Topics: Adult; Aged; Asthma; Delayed-Action Preparations; Female; Humans; Intestinal Absorption; Kinetics; M | 1986 |
Comparison of 12-hour and 24-hour sustained-release theophylline in outpatient management of asthma.
Topics: Adult; Asthma; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Theophylline | 1987 |
Mnemonic effects of asthma medication in children.
Topics: Adolescent; Asthma; Child; Drug Therapy, Combination; Humans; Memory; Steroids; Theophylline; Time F | 1986 |
[Use of teonikol in bronchial asthma in children].
Topics: Adolescent; Asthma; Child; Humans; Theophylline; Xanthinol Niacinate | 1986 |
[Manifestations of cardiac arrhythmia in halothane anesthesia in asthmatic patients treated with theophylline].
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Inhalation; Arrhythmias, Cardiac; Asthma; Drug Interacti | 1986 |
Optimal time for obtaining peak and trough theophylline levels in 12-hour and 24-hour products in children.
Topics: Asthma; Child; Delayed-Action Preparations; Humans; Theophylline; Time Factors | 1987 |
[Clinical significance of serum theophylline levels in patients with bronchial asthma].
Topics: Adult; Aged; Asthma; Female; Humans; Male; Middle Aged; Theophylline | 1985 |
[The nurse in front of an asthma crisis].
Topics: Aerosols; Albuterol; Asthma; Blood Gas Analysis; Emergencies; Humans; Theophylline | 1985 |
Management of acute asthma attacks in Auckland A & E departments.
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Aerosols; Asthma; Bronchodilator Agents; | 1985 |
Determination of theophylline in serum with the Seralyzer Aris reagent strip test evaluated.
Topics: Antibodies, Monoclonal; Asthma; Chromatography, High Pressure Liquid; Evaluation Studies as Topic; H | 1985 |
Plasma theophylline concentrations.
Topics: Asthma; Humans; Theophylline | 1985 |
Underutilisation of prophylactic drugs in asthmatic children.
Topics: Administration, Oral; Adolescent; Adrenal Cortex Hormones; Asthma; Child; Child, Preschool; Cromolyn | 1985 |
[Monitoring long-term therapy with theophylline preparations in children with asthma].
Topics: Adolescent; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Humans; Kinetics; Long-Ter | 1985 |
Advances in the treatment of bronchial asthma.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Asthma; Cromolyn Sodium; Hospitalization; Humans; In | 1985 |
Cromolyn sodium in the treatment of asthma: coming of age in the United States.
Topics: Aerosols; Asthma; Biological Availability; Bronchi; Bronchial Provocation Tests; Bronchial Spasm; Cr | 1985 |
COPD. Assessing functional status.
Topics: Anti-Bacterial Agents; Asthma; Bronchitis; Bronchodilator Agents; Emphysema; Heart Diseases; Hospita | 1985 |
[Routine treatment methods in respiratory allergy].
Topics: Administration, Topical; Adrenal Cortex Hormones; Asthma; Cromolyn Sodium; Delayed-Action Preparatio | 1985 |
Evaluation of serum theophylline concentrations following administration of sustained-release beads in applesauce to asthmatic preschool children.
Topics: Asthma; Child, Preschool; Delayed-Action Preparations; Fruit; Humans; Kinetics; Theophylline | 1986 |
Serum theophylline concentrations are not affected by coadministration of doxycycline.
Topics: Adolescent; Adult; Asthma; Child; Doxycycline; Drug Therapy, Combination; Female; Humans; Male; Midd | 1986 |
Effects of treatment on mortality from asthma.
Topics: Administration, Oral; Adolescent; Albuterol; Asthma; Child; Child, Preschool; Female; Humans; Inject | 1986 |
Perforated gastric ulcer in an asthmatic treated with theophylline and steroids. Case report and literature review.
Topics: Adolescent; Asthma; Female; Humans; Peptic Ulcer Perforation; Prednisone; Status Asthmaticus; Stomac | 1986 |
Hemoperfusion/hemodialysis in the treatment of acute theophylline poisoning--description of a fatal case.
Topics: Asthma; Female; Hemoperfusion; Humans; Middle Aged; Renal Dialysis; Theophylline; Time Factors | 1986 |
Theophylline--how much is enough?
Topics: Asthma; Dose-Response Relationship, Drug; Humans; Respiratory Function Tests; Theophylline | 1986 |
Food and fasting absorption of a single dose of a sustained release theophylline sprinkle formulation in children.
Topics: Asthma; Biological Availability; Capsules; Child; Child, Preschool; Drug Administration Schedule; Fe | 1986 |
[Sustained-release theophylline: study in a child population].
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug | 1986 |
Theophylline compliance in asthmatic children.
Topics: Adolescent; Asthma; Behavior Therapy; Child; Child, Preschool; Humans; Infant; Parents; Patient Comp | 1985 |
Crying-induced bronchospasm in childhood asthma: response to medical management.
Topics: Adolescent; Asthma; Bronchial Spasm; Child; Child, Preschool; Crying; Humans; Immunotherapy; Infant; | 1985 |
The acute asthmatic in the emergency department: the decision to admit or discharge.
Topics: Acute Disease; Asthma; Emergency Service, Hospital; Glucocorticoids; Hospitalization; Humans; Patien | 1985 |
Pharmacokinetics of a sustained-release theophylline preparation in infants and preschool children with asthma.
Topics: Asthma; Child, Preschool; Delayed-Action Preparations; Female; Humans; Infant; Kinetics; Male; Theop | 1985 |
Inconsistent absorption from a sustained-release theophylline preparation during continuous therapy in asthmatic children.
Topics: Adolescent; Aminophylline; Asthma; Biological Availability; Child; Child, Preschool; Chromatography, | 1985 |
[Serum levels and spirometric response with sustained release theophylline].
Topics: Adult; Aminophylline; Asthma; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Respir | 1985 |
Central nervous system effects of antiasthma medication--an EEG study.
Topics: Adrenal Cortex Hormones; Adult; Asthma; Central Nervous System; Child; Dose-Response Relationship, D | 1985 |
Rectal absorption of a theophylline solution in asthma.
Topics: Acute Disease; Asthma; Child, Preschool; Female; Humans; Infant; Intestinal Absorption; Male; Rectum | 1985 |
[Asthma and its pitfalls].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Asthma; Child; Child, Preschool; Humans; Infant; M | 1985 |
Nocturnal asthma and use of long-acting theophylline.
Topics: Asthma; Child; Humans; Theophylline | 1985 |
Guidelines for the use of theophylline in children with asthma. Allergy Section, Canadian Paediatric Society, Winnipeg, Manitoba.
Topics: Administration, Oral; Adolescent; Asthma; Child; Child, Preschool; Humans; Infant; Infusions, Parent | 1985 |
[Relation between blood theophylline levels and bronchodilator effect in asthmatics: comparison with salbutamol].
Topics: Adult; Albuterol; Asthma; Humans; Middle Aged; Theophylline | 1985 |
Compliance with oral theophylline therapy in asthmatic children.
Topics: Adolescent; Asthma; Attitude to Health; Child; Health Knowledge, Attitudes, Practice; Humans; Patien | 1985 |
[The significance of measuring theophylline and its metabolites in the sera of children with bronchial asthma].
Topics: Adolescent; Adult; Asthma; Child; Chromatography, High Pressure Liquid; Female; Humans; Kinetics; Ma | 1985 |
The effects of acute viral hepatitis on theophylline clearance.
Topics: Acute Disease; Adolescent; Asthma; Hepatitis, Viral, Human; Humans; Kinetics; Male; Theophylline | 1985 |
Night-time pharmacokinetics of once a day theophylline: a steady state comparison of three preparations.
Topics: Adult; Asthma; Circadian Rhythm; Drug Administration Schedule; Humans; Male; Metabolic Clearance Rat | 1985 |
Unexpected death in childhood asthma. A review of 13 deaths in ambulatory patients.
Topics: Adolescent; Adult; Asthma; Child; Death, Sudden; Female; Humans; Isoproterenol; Male; Retrospective | 1985 |
Effect of rifampicin administration on theophylline pharmacokinetics in humans.
Topics: Adult; Asthma; Drug Interactions; Humans; Kinetics; Lung Diseases, Obstructive; Male; Rifampin; Theo | 1985 |
The use of halothane in the treatment of status asthmaticus.
Topics: Adult; Airway Resistance; Asthma; Halothane; Humans; Male; Status Asthmaticus; Theophylline; Time Fa | 1985 |
Managing asthma and COPD in patients with cardiovascular disease.
Topics: Adult; Aged; Arrhythmias, Cardiac; Asthma; Cardiovascular Diseases; Digitalis; Digitalis Glycosides; | 1985 |
Theophylline and fibrocystic breast disease.
Topics: Adult; Age Factors; Asthma; Caffeine; Estrogens; Female; Fibrocystic Breast Disease; Humans; Menopau | 1985 |
The effect of phenobarbital on theophylline disposition in children with asthma.
Topics: Asthma; Child; Drug Administration Schedule; Drug Interactions; Female; Humans; Kinetics; Male; Phen | 1985 |
The relationship of cerebrospinal fluid and plasma theophylline concentrations in children and adolescents taking theophylline.
Topics: Adolescent; Adult; Asthma; Blood-Brain Barrier; Child; Child, Preschool; Electroencephalography; Hum | 1985 |
The pharmacology and therapeutic use of theophylline.
Topics: Asthma; Humans; Theophylline | 1985 |
Sustained-release theophylline therapy in Thai asthmatic children.
Topics: Adolescent; Asthma; Bronchodilator Agents; Child; Delayed-Action Preparations; Female; Humans; Male; | 1985 |
"Noninvasive" oral treatment of asthma in the emergency room.
Topics: Acute Disease; Administration, Oral; Aerosols; Asthma; Emergency Service, Hospital; Humans; Infusion | 1985 |
Behavioral strategies and theophylline compliance in asthmatic children.
Topics: Asthma; Behavior Therapy; Child; Chronic Disease; Drug Administration Schedule; Exercise Test; Human | 1985 |
[Pharmacokinetics of a new slow-release theophylline preparation in asthmatic children].
Topics: Asthma; Capsules; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Kinetics; Ma | 1985 |
Salivary composition in asthmatic children on theophylline.
Topics: Asthma; Child; Child, Preschool; Humans; Saliva; Theophylline | 1985 |
Salivary theophylline: a reliable alternative to monitoring serum levels?
Topics: Adolescent; Asthma; Child; Child, Preschool; Female; Humans; Male; Saliva; Theophylline | 1985 |
Theophylline toxicity.
Topics: Asthma; Behavior; Diuresis; Dose-Response Relationship, Drug; Heart; Humans; Nausea; Nervous System; | 1985 |
Clinical pharmacodynamics of theophylline.
Topics: Asthma; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Intestinal Absorption; K | 1985 |
Inhaled corticosteroid therapy: a substitute for theophylline as well as prednisolone?
Topics: Adrenal Cortex Hormones; Aerosols; Asthma; Humans; Prednisolone; Theophylline | 1985 |
[Significance of serum theophylline levels in the management of childhood asthma].
Topics: Asthma; Bronchial Provocation Tests; Child; Child, Preschool; Humans; Infant; Suppositories; Theophy | 1985 |
[Theophylline and its derivatives].
Topics: Aminophylline; Asthma; Bronchi; Bronchial Spasm; Drug Evaluation; Drug Interactions; Dyphylline; Hum | 1985 |
Slow release choline theophyllinate (Sabidal SR 270) in chronic asthma.
Topics: Adult; Asthma; Choline; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Theophylline | 1985 |
Pharmacokinetics and pharmacodynamics of three sustained-release theophylline preparations (Theograd, 350 mg Theolair Retard, and 300 mg Theolin Retard) in steady state in six normals and six patients with chronic asthmatic bronchitis--Part II: Lung funct
Topics: Adult; Airway Resistance; Asthma; Bronchitis; Delayed-Action Preparations; Female; Forced Expiratory | 1985 |
Serum theophylline--a mandatory measurement in the control of therapy?
Topics: Adolescent; Adult; Asthma; Delayed-Action Preparations; Female; Humans; Kinetics; Lung Diseases, Obs | 1985 |
[Minimal blood levels of theophylline: circadian rhythm].
Topics: Aged; Asthma; Circadian Rhythm; Female; Humans; Lung Diseases, Obstructive; Male; Middle Aged; Theop | 1985 |
Tropical island asthma in Hawaii.
Topics: Adolescent; Adult; Aerosols; Aged; Asthma; Child; Child, Preschool; Dust; Ethnicity; Female; Hair; H | 1985 |
Treatment of asthma in preschool children with slow release theophylline.
Topics: Asthma; Child, Preschool; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; | 1985 |
[Administration of E-0686 granule, sustained-release theophylline, for asthmatic infants].
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Evaluation; Female; Humans; Male; | 1985 |
[Simple and rapid estimation of serum theophylline concentrations using the apoenzyme reactivation immunoassay system].
Topics: Apoenzymes; Asthma; Humans; Immunoassay; Theophylline | 1985 |
Evaluation of a sustained-release theophylline tablet in young asthmatics.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Drug Administration Schedule; Evaluati | 1985 |
Membrane systems: practical applications.
Topics: Administration, Topical; Asthma; Bronchitis; Delayed-Action Preparations; Drug Implants; Estriol; Fe | 1985 |
[Aggressive behavior as a side effect of ethylenediamine (but not of theophylline)].
Topics: Aggression; Aminophylline; Asthma; Child; Delayed-Action Preparations; Ethylenediamines; Humans; Mal | 1985 |
Sustained release theophylline for the forgetful asthmatic.
Topics: Adolescent; Asthma; Child; Delayed-Action Preparations; Drug Administration Schedule; Humans; Male; | 1985 |
Steady-state evaluation of twice-a-day dosing of a new sustained-release theophylline preparation for young children.
Topics: Absorption; Asthma; Child; Child, Preschool; Delayed-Action Preparations; Female; Humans; Male; Theo | 1985 |
Theophylline absorption in young asthmatic children receiving sustained-release formulations.
Topics: Asthma; Biological Availability; Child; Child, Preschool; Delayed-Action Preparations; Humans; Intes | 1985 |
Clinical and bronchodilating efficacy of controlled-release theophylline as a function of its serum concentrations in preschool children.
Topics: Asthma; Child; Child, Preschool; Delayed-Action Preparations; Dose-Response Relationship, Drug; Doub | 1985 |
[Transition from parenteral to oral theophylline therapy in asthmatic patients].
Topics: Administration, Oral; Asthma; Drug Therapy, Combination; Female; Humans; Infusions, Parenteral; Male | 1985 |
Relationship between plasma and stimulated-saliva concentrations of theophylline in asthmatic children.
Topics: Asthma; Child; Child, Preschool; Female; Humans; Male; Monitoring, Physiologic; Saliva; Theophylline | 1985 |
[Treatment of asthmatic crisis in children with immediate-action theophylline].
Topics: Asthma; Child; Child, Preschool; Humans; Infant; Status Asthmaticus; Theophylline | 1985 |
A comparative study of the use of choline theophyllinate and a sustained-release theophylline in adults with chronic asthma.
Topics: Administration, Oral; Adult; Aged; Asthma; Bronchodilator Agents; Choline; Delayed-Action Preparatio | 1985 |
Comparison of two calcium antagonists, verapamil and gallopamil (D-600), in exercise-induced asthma.
Topics: Administration, Oral; Adolescent; Adult; Asthma; Blood Pressure; Choline; Forced Expiratory Volume; | 1985 |
Theophylline: still many mysteries.
Topics: Adult; Asthma; Humans; Kinetics; Theophylline | 1985 |
Methylxanthine therapy and reversible airway obstruction.
Topics: Adult; Age Factors; Asthma; Child; Delayed-Action Preparations; Diet; Drug Interactions; Half-Life; | 1985 |
Study of two controlled-release theophylline preparations.
Topics: Adolescent; Adult; Asthma; Biological Availability; Delayed-Action Preparations; Drug Administration | 1985 |
Studies on the pharmacokinetics of theophylline in asthmatic patients following multiple oral dosing of a sustained-release theophylline tablet formulation.
Topics: Administration, Oral; Adult; Asthma; Carrier Proteins; Delayed-Action Preparations; Female; Humans; | 1985 |
[Monitoring serum concentrations of theophylline during aminophylline infusion therapy].
Topics: Adolescent; Adult; Aminophylline; Asthma; Humans; Infusions, Parenteral; Middle Aged; Theophylline | 1985 |
Recent advances in the drug treatment of asthma.
Topics: Acetylcholine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic be | 1972 |
Management of respiratory allergy by nonallergists. 2. Asthma.
Topics: Aerosols; Allergens; Aminophylline; Asthma; Bronchodilator Agents; Central Nervous System Stimulants | 1973 |
[Treatment of asthma].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Allergens; Anti-Bact | 1973 |
Platelet aggregation in asthmatic and normal subjects.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Aminophylline; Asthma; Ephedrine; Epinephrine | 1974 |
[Bronchial asthma in children. II. Prevention by medication].
Topics: Asthma; Child; Cromolyn Sodium; Histamine H1 Antagonists; Humans; Sympathomimetics; Theophylline | 1974 |
Bronchodilators. Part I.
Topics: Adrenergic beta-Agonists; Animals; Asthma; Atropine; Bronchi; Bronchitis; Bronchodilator Agents; Dru | 1974 |
Hypovolaemia in status asthmaticus.
Topics: Adolescent; Adult; Asthma; Blood Pressure; Blood Proteins; Blood Volume; Central Venous Pressure; Ch | 1969 |
A clinical index of disability due to chronic asthma tested during a trial of cromolyn sodium treatment.
Topics: Asthma; Cromolyn Sodium; Disability Evaluation; Ephedrine; Epinephrine; Humans; Methods; Prednisone; | 1973 |
[Treatment of bronchial asthma at home and in hospital (author's transl)].
Topics: Acute Disease; Anti-Bacterial Agents; Asthma; Blood Gas Analysis; Delayed-Action Preparations; Ephed | 1974 |
Nasal congestion as a side effect of cromolyn sodium.
Topics: Asthma; Cromolyn Sodium; Guaifenesin; Humans; Male; Nasal Mucosa; Prednisone; Skin Tests; Theophylli | 1974 |
Letter: Psychosis associated with sympathomimetic and cromoglycate therapy.
Topics: Adult; Asthma; Cromolyn Sodium; Female; Humans; Metaproterenol; Psychoses, Substance-Induced; Theoph | 1974 |
A niacinamide-theophylline compound (RC-C-144). II. Clinical and spirometric effects.
Topics: Adult; Aged; Asthma; Bronchitis; Female; Humans; Male; Middle Aged; Niacinamide; Pulmonary Emphysema | 1966 |
A niacinamide-theophylline compound (RC-C-144). I. Human absorption and blood level studies.
Topics: Adult; Aged; Asthma; Bronchitis; Female; Humans; Male; Middle Aged; Niacinamide; Pulmonary Emphysema | 1966 |
Clinical evaluation of an antiasthmatic compound. Correlation of absorption with blood levels of theophylline.
Topics: Adult; Aged; Asthma; Guaifenesin; Humans; Male; Middle Aged; Phenylpropanolamine; Sympathomimetics; | 1966 |
[What errors should be avoided in the treatment of asthma?].
Topics: Adrenal Cortex Hormones; Adult; Aerosols; Age Factors; Anti-Bacterial Agents; Asthma; Child, Prescho | 1971 |
[Disodium cromoglycate in the treatment of asthma in childhood].
Topics: Adolescent; Adrenocorticotropic Hormone; Age Factors; Asthma; Bronchodilator Agents; Child; Child, P | 1971 |
[Therapy of bronchial asthma and asthma-like conditions].
Topics: Adrenocorticotropic Hormone; Adult; Aerosols; Anemia, Aplastic; Antimalarials; Asthma; Breathing Exe | 1972 |
[Experimental asthma in guinea pigs and autonomic mediators].
Topics: Animals; Asthma; Atropine; Autonomic Agents; Cyclic AMP; Disease Models, Animal; Guinea Pigs; Hexame | 1972 |
Alterations in cyclic AMP metabolism in human bronchial asthma. II. Leukocyte and lymphocyte responses to prostaglandins.
Topics: Asthma; Cyclic AMP; Drug Synergism; Epinephrine; Humans; Isoproterenol; Leukocytes; Lymphocytes; Pro | 1973 |
Alterations in cyclic AMP metabolism in human bronchial asthma. 3. Leukocyte and lymphocyte responses to steroids.
Topics: Asthma; Cyclic AMP; Drug Synergism; Epinephrine; Humans; Hydrocortisone; Isoproterenol; Leukocytes; | 1973 |
[Drug treatment of bronchial asthma].
Topics: Adrenal Cortex Hormones; Asthma; Histamine H1 Antagonists; Humans; Nitrites; Papaverine; Parasympath | 1965 |
[Clinical experiences with a new combination of anti-allergic drugs in respiratory pathology].
Topics: Asthma; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Sympathomimetics; Theophylli | 1965 |
[Experiences with the psychotonic captagon in ambulant psychiatric patients].
Topics: Asthma; Central Nervous System Stimulants; Humans; Mental Disorders; Theophylline | 1965 |
[Clinical experiences with a new drug association with anti-asthmatic action].
Topics: Adult; Aged; Amines; Asthma; Bronchitis; Bronchodilator Agents; Female; Histamine H1 Antagonists; Hu | 1967 |
Management of the child with allergic asthma and rhinitis.
Topics: Adult; Antigen-Antibody Reactions; Asthma; Child, Preschool; Desensitization, Immunologic; Ephedrine | 1969 |
Drug treatment of the out-patient asthmatic (chronic asthmatic).
Topics: Asthma; Chronic Disease; Ephedrine; Epinephrine; Histamine H1 Antagonists; Humans; Immunosuppressive | 1969 |
The dangers of therapeutic agents used in the treatment of asthma.
Topics: Aminophylline; Analgesics; Asthma; Barbiturates; Epinephrine; Histamine H1 Antagonists; Humans; Intu | 1969 |
[Experimental research on the anti-asthmatic action of morpholino-methyl-theophylline].
Topics: Animals; Arteries; Asthma; Blood Pressure; Bronchodilator Agents; Electrocardiography; Female; Guine | 1967 |
[Therapeutic action of a drug with constant and prolonged release (Netaprina Dospan) in the treatment of various obstructive broncho-pneumopathies].
Topics: Adolescent; Adult; Asthma; Bronchi; Bronchodilator Agents; Delayed-Action Preparations; Histamine H1 | 1970 |
[Clinical study of a new pharmacologic combination in the therapy of allergic respiratory diseases].
Topics: Adolescent; Adult; Aged; Asthma; Bronchodilator Agents; Ephedrine; Female; Histamine H1 Antagonists; | 1969 |
[Drug therapy of asthma and bronchitis].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Antitussive Agents; Asthma | 1971 |
[Asthma treatment].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Asthma; Desensitization, Immunologic; Histamine H | 1971 |
Alterations in cyclic adenosine monophosphate metabolism in human bronchial asthma. I. Leukocyte responsiveness to -adrenergic agents.
Topics: Adrenergic beta-Agonists; Asthma; Cells, Cultured; Centrifugation, Density Gradient; Cyclic AMP; Epi | 1973 |
The effects pf 'Nethaprin' Syrup in chronic asthmatic children.
Topics: Aminoisobutyric Acids; Asthma; Blood Pressure; Bronchodilator Agents; Child; Doxylamine; Ephedrine; | 1974 |
Oral salbutamol in bronchial asthma.
Topics: Administration, Oral; Albuterol; Asthma; Drug Combinations; Ephedrine; Humans; Phenobarbital; Theoph | 1974 |
Letter: Management of asthma.
Topics: Adult; Aminophylline; Asthma; Child; Humans; Theophylline | 1974 |
Letter: Vehicle for oral theophylline.
Topics: Administration, Oral; Asthma; Drug Combinations; Ephedrine; Ethanol; Humans; Pharmaceutical Vehicles | 1974 |
[Combinated oral antiasthmatics--how effective are they? An invitation to discussion].
Topics: Administration, Oral; Antipyrine; Asthma; Caffeine; Drug Combinations; Ephedrine; Humans; Parasympat | 1974 |
[Action of intravenous injection of theophylline-ethylenediamine on the pulmonary circulation in normal subjects, asthmatics and patients with chronic bronchitis, studied by radioisotope methods].
Topics: Asthma; Bronchitis; Chronic Disease; Ethylenediamines; Humans; Lung; Pulmonary Circulation; Radionuc | 1974 |
Problems with asthma.
Topics: Adult; Antifungal Agents; Asthma; Candida albicans; Candidiasis; Candidiasis, Oral; Ephedrine; Human | 1972 |
History of the introduction of theophylline into the treatment of asthma.
Topics: Aminophylline; Animals; Asthma; Cattle; Drug Therapy; Germany; History of Medicine; Theophylline; Un | 1974 |
[What's new in the treatment of asthma?].
Topics: Adrenal Cortex Hormones; Asthma; Cromolyn Sodium; Desensitization, Immunologic; Isoproterenol; Metap | 1972 |
[Pediatric Asthma-Bisolvon suppositories in the treatment of asthmatic bronchitis and bronchial asthma in childhood].
Topics: Adolescent; Antipyrine; Asthma; Barbiturates; Benzyl Compounds; Bronchitis; Child; Child, Preschool; | 1972 |
[A dimefline-theophylline association in the treatment of dyspnea due to bronchial spasm].
Topics: Adolescent; Adult; Asthma; Bronchial Neoplasms; Bronchial Spasm; Child; Drug Combinations; Dyspnea; | 1972 |
[Therapy and mortality in status asthmaticus].
Topics: Adrenal Cortex Hormones; Age Factors; Aged; Asphyxia; Asthma; Austria; Diazepam; Female; Humans; Int | 1972 |
A re-evaluation of parenteral aminophylline.
Topics: Administration, Oral; Airway Resistance; Aminophylline; Asthma; Bronchodilator Agents; Child; Dose-R | 1973 |
Blood levels following oral administration of theophylline preparations.
Topics: Administration, Oral; Adolescent; Adult; Aminophylline; Asthma; Child; Dosage Forms; Ethanol; Humans | 1973 |
Triploidy 69, XXX in a stillborn girl.
Topics: Adult; Asthma; Chromatids; Chromosome Aberrations; Chromosomes, Human, 1-3; Chromosomes, Human, 13-1 | 1973 |
[Treatment of asthmatic attacks and asthmatic conditions in general practice].
Topics: Adolescent; Adult; Aged; Aminopyrine; Asthma; Child; Drug Combinations; Ephedrine; Family Practice; | 1973 |
[Study of chemically obtained derivatives of theophylline].
Topics: Animals; Asthma; Blood Pressure; Diuresis; Guinea Pigs; Lethal Dose 50; Mice; Rabbits; Respiration; | 1973 |
Special problems in respiratory diseases.
Topics: Adrenal Cortex Hormones; Aged; Aging; Anti-Bacterial Agents; Anticoagulants; Asthma; Bronchodilator | 1974 |
Indirect plasma-theophylline monitoring in asthmatic children by determination of theophylline concentration in saliva.
Topics: Adolescent; Asthma; Child; Female; Humans; Hydrogen-Ion Concentration; Male; Saliva; Secretory Rate; | 1974 |
Editorial: Rational use of theophylline for bronchodilatation.
Topics: Administration, Oral; Asthma; Bronchodilator Agents; Child; Half-Life; Humans; Theophylline | 1974 |
Effect of oral prednisone on the measurement of plasma steroid concentrations by the competitive protein-binding radioassay.
Topics: Asthma; Binding, Competitive; Body Weight; Child; Fluorometry; Humans; Hydrocortisone; Methylprednis | 1974 |
[What is certain in the therapy of unspecific lung diseases?].
Topics: Anti-Bacterial Agents; Asthma; Bronchiectasis; Empyema; Humans; Lung Abscess; Lung Diseases; Lung Di | 1969 |
Long term prophylaxis of childhood asthma using cromolyn sodium.
Topics: Adolescent; Aerosols; Asthma; Child; Chromones; Cromolyn Sodium; Dexamethasone; Female; Humans; Isop | 1971 |
[Therapeutic trial of an association of theophylline and proscillaridin A in the treatment of cor pulmonale and of some decompensated heart diseases].
Topics: Adult; Aged; Asthma; Atrial Fibrillation; Bufanolides; Chronic Disease; Diuresis; Electrocardiograph | 1971 |
Psychosis accompanying use of bronchodilator compound.
Topics: Adult; Asthma; Bronchodilator Agents; Ephedrine; Humans; Hydroxyzine; Male; Psychoses, Substance-Ind | 1971 |
[Attempted clinical classification of asthma. New therapeutic agent with a prolonged effect].
Topics: Asthma; Bronchodilator Agents; Delayed-Action Preparations; Ephedrine; Humans; Phenobarbital; Theoph | 1971 |
[Antiasthmatic effect of 114 TE].
Topics: Animals; Asthma; Bronchodilator Agents; Guinea Pigs; Propylene Glycols; Theophylline | 1971 |
[What errors should be avoided in the treatment of asthma?].
Topics: Adult; Aerosols; Asthma; Child, Preschool; Desensitization, Immunologic; Glucocorticoids; Humans; Ma | 1971 |
Rectal aminophylline (blood levels with concentrated solutions).
Topics: Absorption; Adult; Aminophylline; Asthma; Child; Humans; Rectum; Solutions; Theophylline | 1971 |
Long- and short-acting epinephrine products in asthmatic children.
Topics: Asthma; Ephedrine; Epinephrine; Humans; Prednisone; Pulmonary Ventilation; Solutions; Theophylline | 1971 |
The hemodynamic and respiratory effects of adrenaline and theophylline derivatives in bronchial asthma.
Topics: Adult; Asthma; Bronchi; Cardiac Catheterization; Epinephrine; Hemodynamics; Humans; Injections, Intr | 1967 |
Metabolic response to epinephrine in bronchial asthma.
Topics: Adrenal Cortex Hormones; Adult; Aged; Asthma; Blood Glucose; Bronchodilator Agents; Drug Synergism; | 1968 |
[Use of oral theophylline in the emergency treatment of asthma].
Topics: Asthma; Female; Humans; Male; Theophylline | 1967 |
[Clinical findings on a combination of bronchodilators and a sedative in bronchial asthma].
Topics: Adolescent; Adult; Asthma; Bronchodilator Agents; Child; Child, Preschool; Chlorides; Ephedrine; Fem | 1970 |
[Therapy of asthmatic dyspnea].
Topics: Asthma; Barbiturates; Drug Synergism; Dyspnea; Glucocorticoids; Humans; Papaverine; Theophylline | 1969 |
[Xantedryl, Xantedrylettae suppositories].
Topics: Asthma; Bronchitis; Child; Dimenhydrinate; Drug Synergism; Ephedrine; Humans; Suppositories; Tablets | 1970 |
Bronchodilators.
Topics: Alcohols; Aminophylline; Asthma; Bronchodilator Agents; Cardiovascular Diseases; Child; Child, Presc | 1970 |
[Advantage of a new therapeutic agent for respiratory dyspneic diseases].
Topics: Asthma; Bronchial Diseases; Bronchodilator Agents; Caffeine; Dyspnea; Male; Parasympatholytics; Theo | 1970 |
Recurrent right middle lobe syndrome in an asthmatic child. Case report and serial vectorcardiographic study.
Topics: Asthma; Child; Cough; Ephedrine; Female; Humans; Middle Lobe Syndrome; Pain; Phenobarbital; Predniso | 1970 |
Pulmonary function in status asthmaticus: effect of therapy.
Topics: Adrenal Cortex Hormones; Adult; Arteries; Asthma; Bronchodilator Agents; Epinephrine; Female; Humans | 1970 |
Theograd, Numotac and Ventolin tablets.
Topics: Administration, Oral; Asthma; Bronchitis; Bronchodilator Agents; Ethanol; Humans; Spirometry; Sympat | 1970 |
Comparison of drugs for asthma.
Topics: Amino Alcohols; Asthma; Blood Pressure; Bronchodilator Agents; Butylamines; Ethanol; Humans; Placebo | 1971 |
A long-acting theophylline preparation.
Topics: Adolescent; Adult; Asthma; Central Nervous System; Delayed-Action Preparations; Female; Humans; Male | 1971 |
[Respiratory physical therapy].
Topics: Aerosols; Airway Resistance; Asthma; Breathing Exercises; Bronchitis; Chronic Disease; Gymnastics; H | 1971 |
[The spirographically controlled treatment of the chronic nonspecific respiratory syndrome].
Topics: Adult; Aged; Asthma; Auscultation; Blood Pressure; Bronchitis; Chronic Disease; Electrocardiography; | 1971 |
[Treatment of asthma with a new prolonged-action drug].
Topics: Asthma; Delayed-Action Preparations; Ephedrine; Humans; Phenobarbital; Theophylline | 1971 |
The effect of oral theophylline on bronchospasm.
Topics: Administration, Oral; Asthma; Bronchial Spasm; Ephedrine; Humans; Theophylline | 1971 |
Arizona, the asthma state; Therapeutic guidelines for students, residents and primary physicians.
Topics: Aminophylline; Anti-Bacterial Agents; Arizona; Asthma; Dyspnea, Paroxysmal; Epinephrine; Humans; Pre | 1971 |
[Verification of the efficacy of heptaminol acefyllinate in asthmatics and chronic respiratory insufficient patients].
Topics: Adolescent; Adult; Aged; Amino Alcohols; Asthma; Chronic Disease; Female; Humans; Male; Middle Aged; | 1971 |
[Clinical experiences with delayed action Perspiran in obstructive respratory disorders].
Topics: Adult; Asthma; Bronchitis; Bronchodilator Agents; Ephedrine; Female; Humans; Male; Middle Aged; Phen | 1967 |
[Analytical pulmonary function studies of the effective duration of a combination preparation in obstructive lung diseases].
Topics: Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Ephedrine; Female; Humans; Male; Oxygen | 1967 |
[Experiences in the treatment of bronchospastic diseases].
Topics: Adult; Aged; Asthma; Bronchitis; Bronchodilator Agents; Chronic Disease; Diphenhydramine; Ephedrine; | 1967 |
[On drug therapy of emphysema and related diseases in more advanced age].
Topics: Aged; Antipyrine; Asthma; Atropa belladonna; Bronchitis; Bronchodilator Agents; Humans; Papaverine; | 1967 |
[A bronchodilator and spasmolytic of a new formula: AC 3810 (trentadil). Clinical trial and comparison with theophylline].
Topics: Aged; Asthma; Bronchial Diseases; Bronchodilator Agents; Dyspnea; Dyspnea, Paroxysmal; Humans; Lung | 1967 |
[On the effect of a broncholytic-bronchosecretolytic combination preparation (N67c-AST) on the mechanics of resporation, respiration volumens and symptomatology in bronchitic syndrome].
Topics: Adult; Asthma; Bronchitis; Drug Synergism; Ephedrine; Expectorants; Humans; Male; Middle Aged; Quate | 1967 |
[Clinical and respiratory function technical studies of the new drug combination Asthmadyn-R in asthmatic clinical states].
Topics: Adult; Aged; Antipyrine; Asthma; Atropa belladonna; Bronchodilator Agents; Diphenhydramine; Ephedrin | 1967 |
Aminophylli Oral vs rectal administration.
Topics: Aminophylline; Asthma; Bronchitis; Enema; Humans; Suppositories; Tablets; Theophylline | 1968 |
[Long-term therapy of asthmoid diseases with asthma-bisolvan (N 67c-AST)].
Topics: Asthma; Bronchitis; Bronchodilator Agents; Ephedrine; Humans; Theophylline | 1968 |
[Aerosol therapy of the respiratory tract. Review of the drug assortment of the German Democratic Republic].
Topics: Adrenal Cortex Hormones; Aerosols; Anesthetics, Local; Anti-Bacterial Agents; Antitubercular Agents; | 1968 |
[On treatment with Trentadil in pediatrics].
Topics: Asthma; Bronchial Spasm; Bronchodilator Agents; Child; Child, Preschool; Humans; Infant; Theophyllin | 1968 |
[Symptomatic treatment of asthma].
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Asthma; Bronchodilator Agents; Dosage Forms; Ephedri | 1968 |
[1st clinical results obtained by new corticoid-stimulation with retard effect: Synacthen Retard].
Topics: Adrenal Cortex Hormones; Adult; Aged; Asthma; Ephedrine; Female; Humans; Male; Middle Aged; Theophyl | 1968 |
[Therapy of obstructive ventilation disorders].
Topics: Adult; Asthma; Bronchitis; Humans; Middle Aged; Noscapine; Theophylline | 1968 |
[Hematic concentrations and therapeutic effectiveness of theophylline monoethanolamine administered in micro-enemas in spastic disorders of the respiratory tract in childhood].
Topics: Asthma; Bronchial Spasm; Bronchitis; Bronchopneumonia; Child; Child, Preschool; Enema; Humans; Infan | 1968 |
[Clinical experiences with a new bronchodilator agent (Marax)].
Topics: Asthma; Bronchitis; Bronchodilator Agents; Ephedrine; Female; Humans; Hydroxyzine; Male; Pulmonary E | 1969 |
[Factory physician and bronchitis].
Topics: Antipyrine; Asthma; Atropa belladonna; Bronchitis; Humans; Occupational Medicine; Papaverine; Phytot | 1969 |
[On the therapy of asthmoid bronchitis with Asthma-Bisolvon].
Topics: Asthma; Bronchitis; Bronchodilator Agents; Ephedrine; Female; Humans; Male; Quaternary Ammonium Comp | 1969 |
Therapeutic effect of an alcohol solution of theophylline and potassium iodide in asthma.
Topics: Adolescent; Asthma; Child; Child, Preschool; Ethanol; Humans; Potassium Iodide; Respiration; Respira | 1969 |
[Report on experiences with a new anti-asthmatic agent].
Topics: Aged; Asthma; Atropa belladonna; Diphenhydramine; Ephedrine; Female; Guaiacol; Humans; Male; Middle | 1969 |
An effective oral medication for long term bronchodilation.
Topics: Adult; Asthma; Bronchitis; Humans; Middle Aged; Pneumonia; Pulmonary Emphysema; Theophylline | 1965 |
[Treatment of asthma-type syndromes with Ambredine].
Topics: Animals; Asthma; Bronchial Spasm; Pulmonary Emphysema; Sulfonamides; Theophylline | 1965 |
Serum theophylline levels and control of asthma following rectal theophylline.
Topics: Adolescent; Asthma; Child; Child, Preschool; Humans; Oxygen Consumption; Respiration; Theophylline | 1966 |
[The treatment of bronchial asthma and the combination treatment of acute and chronic bronchial, bronchopulmonary and pulmonary infections with Asthma 23D. An experience report of medical practice during the time period of 5 years].
Topics: Acute Disease; Adult; Aminopyrine; Anti-Bacterial Agents; Antitubercular Agents; Asthma; Atropa bell | 1966 |