theophylline and Asphyxia Neonatorum studies

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the effects of prophylactic theophylline in renal function and survival rates of asphyxiated newborns."	9.12	Effectiveness of theophylline administration in neonates with perinatal asphyxia: a meta-analysis. ( Bellos, I; Pandita, A; Yachha, M, 2021)
"To compare the efficacy and safety of theophylline or aminophylline for prevention of acute kidney injury (AKI) in neonates and children."	9.01	Theophylline and aminophylline for prevention of acute kidney injury in neonates and children: a systematic review. ( Bhatt, GC; Bitzan, M; Das, RR; Gogia, P, 2019)
"The effect of theophylline on cerebral blood flow (CBF), oxygen transport, and energy metabolism was investigated during and following brief episodes of asphyxia."	7.69	Cerebral blood flow and metabolism during repeated asphyxias in newborn piglets: influence of theophylline. ( Delivoria-Papadopoulos, M; Goplerud, JM, 1994)
"The simultaneous determination of caffeine and theophylline plasmatic levels has been proposed when the later is used in the treatment of the newborn's apnea."	7.68	[Importance of monitoring theophylline and caffeine plasma levels in the management of neonatal apnea]. ( Sacristán del Castillo, JA; Soto Alvarez, J, 1991)
"To evaluate the effects of prophylactic theophylline in renal function and survival rates of asphyxiated newborns."	5.12	Effectiveness of theophylline administration in neonates with perinatal asphyxia: a meta-analysis. ( Bellos, I; Pandita, A; Yachha, M, 2021)
"To compare the efficacy and safety of theophylline or aminophylline for prevention of acute kidney injury (AKI) in neonates and children."	5.01	Theophylline and aminophylline for prevention of acute kidney injury in neonates and children: a systematic review. ( Bhatt, GC; Bitzan, M; Das, RR; Gogia, P, 2019)
"The effect of theophylline on cerebral blood flow (CBF), oxygen transport, and energy metabolism was investigated during and following brief episodes of asphyxia."	3.69	Cerebral blood flow and metabolism during repeated asphyxias in newborn piglets: influence of theophylline. ( Delivoria-Papadopoulos, M; Goplerud, JM, 1994)
"The simultaneous determination of caffeine and theophylline plasmatic levels has been proposed when the later is used in the treatment of the newborn's apnea."	3.68	[Importance of monitoring theophylline and caffeine plasma levels in the management of neonatal apnea]. ( Sacristán del Castillo, JA; Soto Alvarez, J, 1991)
" This view assumes that pharmacologic manipulation of apnea of prematurity is in itself a desirable goal and clearly superior to treatment of apneic episodes when they occur."	3.66	Adverse effects of caffeine and theophylline in the newborn infant. ( Aranda, JV; Clozel, M; Howell, J, 1981)
"Those infants with asphyxial renal failure were followed up for 1 year."	2.72	Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. ( Bhat, MA; Makhdoomi, MS; Mufti, MH; Shah, ZA, 2006)
"Aminophylline has been shown to reduce severe renal dysfunction in neonates after perinatal asphyxia."	1.62	Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia. ( Cho, SH; Chock, VY; Frymoyer, A, 2021)
"Gestational age, gender, duration of treatment, body weight, and Apgar scores were not found to correlate significantly with theophylline clearance."	1.27	Factors influencing theophylline disposition in 179 newborns. ( Erkan, NV; Gal, P; Gilman, JT; Hersh, CB; Levine, RS, 1986)

Research

Studies (24)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Calculated Estimated Glomerular Filtration Rate (eGFR)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (37.50)	18.7374
1990's	2 (8.33)	18.2507
2000's	4 (16.67)	29.6817
2010's	7 (29.17)	24.3611
2020's	2 (8.33)	2.80

Authors	Studies
Bellos, I	1
Pandita, A	2
Yachha, M	2
Chock, VY	1
Cho, SH	1
Frymoyer, A	1
Bhatt, GC	1
Gogia, P	1
Bitzan, M	1
Das, RR	1
Aydin, M	1
Hakan, N	1
Zenciroglu, A	1
Okumus, N	1
Al-Wassia, H	2
Raina, A	1
Harish, R	1
Jamwal, A	1
Askenazi, D	1
Eslami, Z	1
Shajari, A	1
Kheirandish, M	1
Heidary, A	1
Allende-Castro, C	1
Espina-Marchant, P	1
Bustamante, D	1
Rojas-Mancilla, E	1
Neira, T	1
Gutierrez-Hernandez, MA	1
Esmar, D	1
Valdes, JL	1
Morales, P	1
Gebicke-Haerter, PJ	1
Herrera-Marschitz, M	1
Alshaikh, B	1
Sauve, R	1
Bakr, AF	1
Bhat, MA	1
Shah, ZA	1
Makhdoomi, MS	1
Mufti, MH	1
Gal, P	2
Boer, HR	1
Toback, J	1
Wells, TJ	1
Erkan, NV	2
Howell, J	1
Clozel, M	1
Aranda, JV	1
Goplerud, JM	1
Delivoria-Papadopoulos, M	1
Jenik, AG	1
Ceriani Cernadas, JM	1
Gorenstein, A	1
Ramirez, JA	1
Vain, N	1
Armadans, M	1
Ferraris, JR	1
Soto Alvarez, J	1
Sacristán del Castillo, JA	1
Closa, RM	1
Tarres Roure, A	1
Gómez Papi, A	1
Casasin Edo, T	1
Gilman, JT	1
Levine, RS	1
Hersh, CB	1
Tervilä, L	1
Vartiainen, E	1
Kivalo, I	1
Finnilä, MJ	1
Väyrynen, M	1
Nobel, J	1
Meyburg, V	1
Lupp, H	1
Mengarda, G	1
Mentzel, H	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784]	Phase 1	18 participants (Anticipated)	Interventional	2024-06-30	Not yet recruiting
The Effect of Aminophylline on Preventing Acute Kidney Injury in Pediatric Patients Undergoing Open Heart Surgery[NCT03897335]	Phase 3	80 participants (Anticipated)	Interventional	2019-02-07	Recruiting
[NCT02276170]		9 participants (Actual)	Observational	2014-10-31	Terminated (stopped due to insufficient rate of accrual)
Perioperative Aminophylline to Improve High Risk Renal Graft Outcome- a Double Blinded, Placebo Controlled, Randomized Clinical Trial[NCT01759862]		50 participants (Actual)	Interventional	2012-11-30	Completed
A Multicenter Randomized Controlled Trial of Therapeutic Hypothermia Plus Magnesium Sulphate (MgSO4) Versus Therapeutic Hypothermia Plus Placebo in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy[NCT01646619]	Phase 3	300 participants (Anticipated)	Interventional	2012-05-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The investigators will measure blood creatinine on post-operative day 5 and using the Schwartz equation will calculate estimated glomerular filtration rate (GFR) to determine kidney function. (NCT01759862)
Timeframe: 5 days

Presence of Fibrosis Measured on Protocol Biopsy

Intervention	ml/min/1.73m2 (Mean)
Aminophylline	67.39
Control	80.48

The investigators will use the same cores that are obtained during routine 6 months protocol biopsies to quantify the amount of fibrosis (NCT01759862)
Timeframe: 6 months

Urinary NGAL (Neutrophil Gelatinase-associated Lipocalin)/ Creatinine Ratio

Intervention	Participants (Count of Participants)
Aminophylline	11
Control	14

urinary NGAL(Neutrophil gelatinase-associated lipocalin) is a biomarker for kidney injury. NGAL levels 12h post-transplant were found to be a marker for development of delayed graft function and need for dialysis post-transplant. NGAL levels are corrected for urine creatinine. (NCT01759862)
Timeframe: 12 hours post transplant

Article	Year
Effectiveness of theophylline administration in neonates with perinatal asphyxia: a meta-analysis. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2021, Volume: 34, Issue:18 Topics: Acute Kidney Injury; Asphyxia; Asphyxia Neonatorum; Glomerular Filtration Rate; Humans; Infant, Newb	2021
Theophylline and aminophylline for prevention of acute kidney injury in neonates and children: a systematic review. Archives of disease in childhood, 2019, Volume: 104, Issue:7 Topics: Acute Kidney Injury; Aminophylline; Asphyxia Neonatorum; Bronchodilator Agents; Child; Child, Presch	2019
Prophylactic theophylline for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia: a systematic review and meta-analysis of randomized controlled trials. Journal of perinatology : official journal of the California Perinatal Association, 2013, Volume: 33, Issue:4 Topics: Asphyxia Neonatorum; Glomerular Filtration Rate; Humans; Infant, Newborn; Infant, Postmature; Intens	2013

Article	Year
Treating perinatal asphyxia with theophylline at birth helps to reduce the severity of renal dysfunction in term neonates. Acta paediatrica (Oslo, Norway : 1992), 2016, Volume: 105, Issue:10 Topics: Asphyxia Neonatorum; Humans; Infant, Newborn; Renal Insufficiency; Theophylline; Vasodilator Agents	2016
Theophylline for prevention of kidney dysfunction in neonates with severe asphyxia. Iranian journal of kidney diseases, 2009, Volume: 3, Issue:4 Topics: Asphyxia Neonatorum; Cohort Studies; Creatinine; Female; Glomerular Filtration Rate; Humans; Infant,	2009
Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia--a study in a developing country. Pediatric nephrology (Berlin, Germany), 2005, Volume: 20, Issue:9 Topics: Asphyxia Neonatorum; Chemoprevention; Developing Countries; Double-Blind Method; Humans; Infant, New	2005
Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia--a study in a developing country. Pediatric nephrology (Berlin, Germany), 2005, Volume: 20, Issue:9 Topics: Asphyxia Neonatorum; Chemoprevention; Developing Countries; Double-Blind Method; Humans; Infant, New	2005
Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia--a study in a developing country. Pediatric nephrology (Berlin, Germany), 2005, Volume: 20, Issue:9 Topics: Asphyxia Neonatorum; Chemoprevention; Developing Countries; Double-Blind Method; Humans; Infant, New	2005
Prophylactic theophylline to prevent renal dysfunction in newborns exposed to perinatal asphyxia--a study in a developing country. Pediatric nephrology (Berlin, Germany), 2005, Volume: 20, Issue:9 Topics: Asphyxia Neonatorum; Chemoprevention; Developing Countries; Double-Blind Method; Humans; Infant, New	2005
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. The Journal of pediatrics, 2006, Volume: 149, Issue:2 Topics: Asphyxia Neonatorum; beta 2-Microglobulin; Body Weight; Creatinine; Glomerular Filtration Rate; Huma	2006
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000
A randomized, double-blind, placebo-controlled trial of the effects of prophylactic theophylline on renal function in term neonates with perinatal asphyxia. Pediatrics, 2000, Volume: 105, Issue:4 Topics: Asphyxia Neonatorum; Double-Blind Method; Glomerular Filtration Rate; Humans; Infant, Newborn; Kidne	2000

Article	Year
Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia. Pediatric research, 2021, Volume: 89, Issue:4 Topics: Acute Kidney Injury; Aminophylline; Asphyxia Neonatorum; Biomarkers; Creatinine; Female; Humans; Hyp	2021
Is the use of prophylactic theophylline safe for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia? Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:1 Topics: Asphyxia Neonatorum; Humans; Infant, Postmature; Renal Insufficiency; Theophylline	2014
Reply to: 'Is the use of prophylactic theophylline safe for the prevention of severe renal dysfunction in term and post-term neonates with perinatal asphyxia?'. Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:1 Topics: Asphyxia Neonatorum; Humans; Infant, Postmature; Renal Insufficiency; Theophylline	2014
Should neonates with perinatal asphyxia receive a single dose of IV theophylline to prevent acute kidney injury? Acta paediatrica (Oslo, Norway : 1992), 2016, Volume: 105, Issue:10 Topics: Acute Kidney Injury; Asphyxia; Asphyxia Neonatorum; Female; Humans; Infant, Newborn; Pregnancy; Theo	2016
Further studies on the hypothesis of PARP-1 inhibition as a strategy for lessening the long-term effects produced by perinatal asphyxia: effects of nicotinamide and theophylline on PARP-1 activity in brain and peripheral tissue : nicotinamide and theophyl Neurotoxicity research, 2012, Volume: 22, Issue:1 Topics: Animals; Animals, Newborn; Asphyxia; Asphyxia Neonatorum; Behavior, Animal; Brain; Heart; Humans; In	2012
Effect of asphyxia on theophylline clearance in newborns. Southern medical journal, 1982, Volume: 75, Issue:7 Topics: Asphyxia Neonatorum; Humans; Infant, Newborn; Theophylline	1982
Adverse effects of caffeine and theophylline in the newborn infant. Seminars in perinatology, 1981, Volume: 5, Issue:4 Topics: Apnea; Asphyxia Neonatorum; Caffeine; Cardiovascular System; Central Nervous System; Digestive Syste	1981
Cerebral blood flow and metabolism during repeated asphyxias in newborn piglets: influence of theophylline. Biology of the neonate, 1994, Volume: 65, Issue:3-4 Topics: Animals; Animals, Newborn; Asphyxia; Asphyxia Neonatorum; Brain; Cerebrovascular Circulation; Diseas	1994
[Importance of monitoring theophylline and caffeine plasma levels in the management of neonatal apnea]. Anales espanoles de pediatria, 1991, Volume: 34, Issue:4 Topics: Apnea; Asphyxia Neonatorum; Caffeine; Humans; Infant, Newborn; Monitoring, Physiologic; Theophylline	1991
[Monitoring theophylline in premature newborn infants]. Anales espanoles de pediatria, 1989, Volume: 30, Issue:4 Topics: Apnea; Asphyxia Neonatorum; Humans; Infant, Newborn; Infant, Premature, Diseases; Monitoring, Physio	1989
Factors influencing theophylline disposition in 179 newborns. Therapeutic drug monitoring, 1986, Volume: 8, Issue:1 Topics: Apgar Score; Asphyxia Neonatorum; Body Weight; Female; Gestational Age; Humans; Infant, Newborn; Inf	1986
The effect of oxygen ventilation and vasodilator on uterine perfusion, fetal oxygen and acid-base balance. I. A study in abnormal gravidae. Acta obstetricia et gynecologica Scandinavica, 1973, Volume: 52, Issue:4 Topics: Acid-Base Equilibrium; Anemia; Asphyxia Neonatorum; Erythroblastosis, Fetal; Female; Fetus; Humans;	1973
[Prevention of fetal asphyxia with theophylline drugs]. Geburtshilfe und Frauenheilkunde, 1970, Volume: 30, Issue:10 Topics: Asphyxia Neonatorum; Electrocardiography; Female; Fetal Death; Fetal Diseases; Heart Rate; Humans; I	1970
[Drug therapy of perinatal asphyxia]. Die Medizinische Welt, 1971, Aug-07, Volume: 31 Topics: Asphyxia Neonatorum; Atropine; Humans; Infant, Newborn; Injections, Intramuscular; Papaverine; Theop	1971
[The association of theophylline, papaverine and methylatropine in the treatment of the idiopathic respiratory syndrome in premature infants]. Minerva pediatrica, 1968, Sep-15, Volume: 20, Issue:37 Topics: Asphyxia Neonatorum; Atropine; Humans; Infant, Newborn; Infant, Premature, Diseases; Papaverine; Res	1968
[Asphyxia neonatorum. II. Treatment with vasodilator and vagolytic agents]. Zeitschrift fur Kinderheilkunde, 1966, Volume: 96, Issue:2 Topics: Acidosis, Respiratory; Asphyxia Neonatorum; Atropine; Blood Circulation; Humans; Hypercapnia; Hypoxi	1966

theophylline and Asphyxia Neonatorum