theophylline and Anoxemia studies

Research Excerpts

Excerpt	Relevance	Reference
"Twelve non-ambulant patients with Duchenne muscular dystrophy underwent a double-blind cross-over clinical trial of slow-release theophylline for the treatment of asymptomatic sleep hypoxaemia."	9.08	A double blind cross over trial of theophylline prophylaxis for sleep hypoxaemia in Duchenne muscular dystrophy. ( Heckmatt, JZ; Khan, Y, 1997)
"The effects of the methylxanthine drugs doxofylline, theophylline and bamifylline were investigated on the basis of clinical and gasometric parameters in hypoxic patients with chronic heart failure."	9.07	Methylxanthine drug therapy in chronic heart failure associated with hypoxaemia: double-blind placebo-controlled clinical trial of doxofylline versus theophylline and bamifylline. ( Bettini, R; Cani, E; Cortellini, G; Dini, FL; Garagnani, A; Gobbi, G; Greco, A; Onorato, G; Pasini, G; Pasini, P, 1993)
" Twelve healthy young men took part in this investigation of the effect of oral theophylline and dipyridamole (two drugs known to affect the pharmacological effects of the purine nucleoside adenosine) on the respiratory response to isocapnic hypoxia."	9.07	Effect of theophylline and dipyridamole on the respiratory response to isocapnic hypoxia in normal human subjects. ( Christie, JM; Griffiths, TL; Holgate, ST; Parsons, ST, 1991)
"A double-blind crossover trial was conducted in 10 asthmatic patients for comparison of fenoterol with salbutamol, in 12 other asthmatic patients for comparison of reproterol with salbutamol, and in 15 other asthmatic patients for comparison of terbutaline with salbutamol."	9.04	[The bronchospasmolytics salbutamol, fenoterol, terbutaline and reproterol. Their effects and side effects in asthmatics after inhalation with an electric nebulizer]. ( Budmiger, H; Kyd, K; Scherrer, M, 1978)
"A limited number of small studies have suggested that methazolamide and theophylline can independently reduce symptoms of acute mountain sickness (AMS) and, if taken together, can improve aerobic exercise performance in normobaric hypoxia."	8.02	Combined methazolamide and theophylline improves oxygen saturation but not exercise performance or altitude illness in acute hypobaric hypoxia. ( Davis, C; Evero, O; Gronewold, J; Nichols, AJ; Reitinger, J; Roach, RC; Subudhi, AW; Van-Houten, SJ, 2021)
" We have investigated how CHU affects cardiovascular responses evoked by acute systemic hypoxia in adult male offspring, recognising that adenosine contributes to hypoxia-induced muscle vasodilatation and bradycardia by acting on A(1) receptors in normal (N) rats."	7.76	Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. ( Coney, AM; Marshall, JM, 2010)
"Adenosine, prostaglandins (PG) and nitric oxide (NO) have all been implicated in hypoxia-evoked vasodilatation."	7.71	Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. ( Abbas, MR; Coney, AM; Marshall, JM; Ray, CJ, 2002)
"This study investigated whether adenosine mediates the decrease in plasma renin activity (PRA) during acute hypoxia."	7.71	Evidence that the renin decrease during hypoxia is adenosine mediated in conscious dogs. ( Arntz, E; Boemke, W; Höhne, C; Kaczmarczyk, G; Krebs, MO, 2001)
" In anaesthetized rats, we have examined the role of adenosine in vasodilatation evoked in the cerebral cortex by systemic hypoxia (breathing 8 % O2)."	7.70	Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. ( Coney, AM; Marshall, JM, 1998)
"1 To investigate the effect of moderate hypoxia alone or combined with an inflammatory reaction or after 3-methylcholanthrene (3MC) pre-treatment on cytochrome P450 (P450), conscious rabbits were exposed for 24 h to a fractional concentration of inspired O2 of 10% (mean PaO2 of 34 mmHg)."	7.70	Effect of hypoxia alone or combined with inflammation and 3-methylcholanthrene on hepatic cytochrome P450 in conscious rabbits. ( Bélanger, PM; Dalkara, S; El-Kadi, AO; Kurdi, J; Maurice, H; Ong, H; Souich, P, 1999)
" Adenosine-receptor blockade with 8-(p-sulfophenyl)-theophylline reduced by 50% the maximum hypoxia-induced rise in plasma ANP concentrations."	7.69	Adenosine modulates hypoxia-induced atrial natriuretic peptide release in fetal sheep. ( Arora, CP; Castro, LC; Koos, BJ; Mason, BA; Ogunyemi, DA, 1995)
"In two groups of Saffan-anaesthetized, spontaneously breathing rats we have attempted to identify the peripheral influences of adenosine in mediating the responses evoked by hypoxia by using an adenosine receptor antagonist, 8-sulphophenyltheophylline (8-SPT, 20 mg kg-1 i."	7.69	Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia. ( Elnazir, BK; Marshall, JM; Thomas, T, 1994)
" In ten spontaneously breathing, Saffan-anaesthetized rats (group I), respiratory and cardiovascular responses evoked by 10 min periods of hypoxia (arterial partial pressure of O2, Pa,O2, 33 mmHg) were recorded before and after the administration of the adenosine receptor antagonist 8-phenyltheophylline (8-PT, 10 mg kg-1 i."	7.69	Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. ( Marshall, JM; Thomas, T, 1994)
" The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit."	7.69	Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994)
" In Saffan-anaesthetized rats, we have further investigated the mechanisms underlying the vasodilatation induced by adenosine in skeletal muscle by acute systemic hypoxia (breathing 8% O2 for 5 min)."	7.69	Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. ( Marshall, JM; Skinner, MR, 1996)
"This study was performed to assess whether nifedipine could prevent the decrease in hepatic cytochrome P450 induced by acute moderate hypoxia or an inflammatory reaction."	7.69	Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction. ( Barakat, M; du Souich, P, 1996)
"The purpose of this study was twofold: 1) to verify a report that a suspension of 8-phenyltheophylline (8-PT) completely abolished hypoxia-induced coronary vasodilation [H."	7.68	Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline. ( Downey, HF; Lee, SC; Mallet, RT; Shizukuda, Y; Williams, AG, 1992)
" In rats anaesthetized with Saffan we have studied the effects of the adenosine receptor antagonists, theophylline and 8-phenyltheophylline, upon the respiratory and cardiovascular responses evoked by 5 min periods of systemic hypoxia."	7.68	The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat. ( Marshall, JM; Neylon, M, 1991)
"Arousal is an important protective mechanism that aids in the resolution of obstructive sleep apnea in adults and children, but its role in neonatal apnea has not been investigated."	7.68	Behavioral arousal in newborn infants and its association with termination of apnea. ( Belan, MA; Cowen, CP; Mathew, OP; Thoppil, CK, 1991)
"These results show that adenosine does play a role in hypoxia induced bradycardia and vagal potentiation."	7.68	Endogenous adenosine enhances vagal negative chronotropic effect during hypoxia in the anaesthetised rabbit. ( Borgdorff, P; Verlato, G, 1990)
"The role of adenosine in hypoxia-induced vasodilation was examined in the intestine of pentobarbital sodium-anesthetized cats."	7.68	Hypoxia-induced vasodilation of the feline superior mesenteric artery is not adenosine mediated. ( Lautt, WW; Lockhart, LK, 1990)
"This study investigated the role of adenosine in the regulation of neonatal cerebral blood flow (CBF) during moderate (arterial PO2 = 47 +/- 9 Torr) and severe (arterial PO2 = 25 +/- 4 Torr) hypoxia."	7.68	Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet. ( Aranda, JV; Beharry, K; Farri, E; Laudignon, N; Rex, J, 1990)
"Previous studies suggest that high levels of adenosine may enhance histamine release and contribute to atrioventricular (AV) nodal conduction arrhythmias during anaphylaxis of isolated guinea pig hearts."	7.67	Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts. ( Heller, LJ; Regal, JF; Trachte, GJ, 1989)
"Anesthetized randomsource mongrel dogs of either sex were instrumented to investigate the effects of 8-phenyltheophylline on changes in coronary perfusion pressure caused by systemic hypoxia under conditions of controlled constant coronary blood flow."	7.67	Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline. ( Kang, YH; Merrill, GF; Wei, HM, 1989)
"Theophylline is a bronchodilator used extensively in the management of obstructive pulmonary disease."	6.38	Hypoxia, arterial pH and theophylline disposition. ( Lam, YW; Richer, M, 1993)
"Theophylline is an oral methylxanthine bronchodilator recommended as alternate therapy for the treatment of asthma and chronic obstructive pulmonary disease (COPD)."	5.41	Theophylline for the management of respiratory disorders in adults in the 21st century: A scoping review from the American College of Clinical Pharmacy Pulmonary Practice and Research Network. ( Abdalla, M; Bissell, B; Boylan, PM; Malesker, MA; Santibañez, M; Smith, Z, 2023)
"Adenosine dilation was also blunted by glibenclamide, a KATP antagonist (9 +/- 2, 14 +/- 3, 21 +/- 4 vs."	5.30	Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation. ( Armstead, WM, 1997)
"In theophylline-treated animals, NMDA responses were completely abolished during hypoxia (28 +/- 2 vs."	5.30	Inhibitory effects of hypoxia and adenosine on N-methyl-D-aspartate-induced pial arteriolar dilation in piglets. ( Bari, F; Busija, DW; Louis, TM; Thore, CR, 1998)
"To investigate the effect of acute hypoxia and concomitant changes in portal blood flow on the disposition of drugs mainly metabolized by the cytochrome P(450) enzymes (CYP) 3A4 (verapamil) and CYP1A2 (theophylline)."	5.11	Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m). ( Bärtsch, P; Burhenne, J; Dehnert, C; Göggelmann, C; Haefeli, WE; Menold, E; Mikus, G; Riedel, KD; Streit, M, 2005)
"The purine nucleoside, adenosine, has been implicated as a neuromodulator in central respiratory depression during prolonged exposure to hypoxia."	5.08	The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine. ( Christie, JM; Griffiths, TL; Holgate, ST; Parsons, ST, 1997)
"Twelve non-ambulant patients with Duchenne muscular dystrophy underwent a double-blind cross-over clinical trial of slow-release theophylline for the treatment of asymptomatic sleep hypoxaemia."	5.08	A double blind cross over trial of theophylline prophylaxis for sleep hypoxaemia in Duchenne muscular dystrophy. ( Heckmatt, JZ; Khan, Y, 1997)
"The effects of the methylxanthine drugs doxofylline, theophylline and bamifylline were investigated on the basis of clinical and gasometric parameters in hypoxic patients with chronic heart failure."	5.07	Methylxanthine drug therapy in chronic heart failure associated with hypoxaemia: double-blind placebo-controlled clinical trial of doxofylline versus theophylline and bamifylline. ( Bettini, R; Cani, E; Cortellini, G; Dini, FL; Garagnani, A; Gobbi, G; Greco, A; Onorato, G; Pasini, G; Pasini, P, 1993)
"To examine the role of endogenous adenosine in hypoxic ventilatory response, we measured, in nine normal young adults, ventilatory responses to isocapnic progressive hypoxia and subsequent sustained hypoxia [arterial O2 saturation (SaO2); 80%, 20 min] with and without pretreatment with dipyridamole in a double-blind crossover fashion."	5.07	Role of endogenous adenosine in hypoxic ventilatory response in humans: a study with dipyridamole. ( Akiyama, Y; Kawakami, Y; Kobayashi, S; Miyamoto, K; Nishimura, M; Yamamoto, M, 1994)
" Twelve healthy young men took part in this investigation of the effect of oral theophylline and dipyridamole (two drugs known to affect the pharmacological effects of the purine nucleoside adenosine) on the respiratory response to isocapnic hypoxia."	5.07	Effect of theophylline and dipyridamole on the respiratory response to isocapnic hypoxia in normal human subjects. ( Christie, JM; Griffiths, TL; Holgate, ST; Parsons, ST, 1991)
"A double-blind crossover trial was conducted in 10 asthmatic patients for comparison of fenoterol with salbutamol, in 12 other asthmatic patients for comparison of reproterol with salbutamol, and in 15 other asthmatic patients for comparison of terbutaline with salbutamol."	5.04	[The bronchospasmolytics salbutamol, fenoterol, terbutaline and reproterol. Their effects and side effects in asthmatics after inhalation with an electric nebulizer]. ( Budmiger, H; Kyd, K; Scherrer, M, 1978)
" Hypoxia induces vasodilation and both adenosine and NO release in the preparation; the NO release under hypoxia is blocked by theophylline."	4.82	Role of nitric oxide in the control of coronary resistance in teleosts. ( Agnisola, C, 2005)
"A limited number of small studies have suggested that methazolamide and theophylline can independently reduce symptoms of acute mountain sickness (AMS) and, if taken together, can improve aerobic exercise performance in normobaric hypoxia."	4.02	Combined methazolamide and theophylline improves oxygen saturation but not exercise performance or altitude illness in acute hypobaric hypoxia. ( Davis, C; Evero, O; Gronewold, J; Nichols, AJ; Reitinger, J; Roach, RC; Subudhi, AW; Van-Houten, SJ, 2021)
" We have investigated how CHU affects cardiovascular responses evoked by acute systemic hypoxia in adult male offspring, recognising that adenosine contributes to hypoxia-induced muscle vasodilatation and bradycardia by acting on A(1) receptors in normal (N) rats."	3.76	Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. ( Coney, AM; Marshall, JM, 2010)
" Tissue glucose uptake and cardiovascular characteristics were measured in the short-horned sculpin, Myoxocephalus scorpius, a species exhibiting low blood glucose levels, during normoxia and hypoxia to assess the role of adenosine receptors in the control of glucose uptake and anaerobic metabolism."	3.74	The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius. ( Driedzic, WR; MacCormack, TJ, 2007)
"Our findings indicate that obese rats possess altered adenosinergic modulation of ventilatory responses to acute and sustained hypoxia in two opposite ways."	3.73	Adenosinergic modulation of ventilation in obese zucker rats. ( Farkas, GA; Lee, SD; Nakano, H, 2005)
" Presynaptic depression of evoked EPSCs by hypoxia or adenosine was significantly larger in alpha-Syn knockout than in wild-type mice, further supporting the hypothesis of regulation of synaptic transmission by alpha-Syn."	3.72	Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice. ( Ceña, V; Fariñas, I; González-García, C; Martín, ED; Milán, M, 2004)
"Adenosine, prostaglandins (PG) and nitric oxide (NO) have all been implicated in hypoxia-evoked vasodilatation."	3.71	Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. ( Abbas, MR; Coney, AM; Marshall, JM; Ray, CJ, 2002)
"This study investigated whether adenosine mediates the decrease in plasma renin activity (PRA) during acute hypoxia."	3.71	Evidence that the renin decrease during hypoxia is adenosine mediated in conscious dogs. ( Arntz, E; Boemke, W; Höhne, C; Kaczmarczyk, G; Krebs, MO, 2001)
" In addition, cerebral arteriolar dilation to hypoxia and adenosine is maintained after ischemia despite the expected impairment in K(ATP) function."	3.70	Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. ( Bari, F; Busija, DW; Louis, TM, 1998)
"Hypoxia was assessed in three murine tumour models in vivo by measuring the incorporation of 7-(4'-(2-nitroimidazole-1-yl)-butyl)-theophylline (NITP), an immunologically identifiable hypoxia marker that binds bioreductively to cells under low-oxygen conditions."	3.70	Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo. ( Hodgkiss, RJ; Webster, L; Wilson, GD, 1998)
" In anaesthetized rats, we have examined the role of adenosine in vasodilatation evoked in the cerebral cortex by systemic hypoxia (breathing 8 % O2)."	3.70	Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. ( Coney, AM; Marshall, JM, 1998)
"This study was designed to assess if opioids or adenosine are involved in the hypometabolism induced by hypoxia in the rat."	3.70	Neuromodulators and hypoxic hypothermia in the rat. ( Gautier, H; Murariu, C, 1998)
"In an in vitro preparation of the intact carotid body (CB) of the rabbit, adenosine (100 microM) inhibited hypoxia-induced catecholamine release by 25%."	3.70	Adenosine inhibits L-type Ca2+ current and catecholamine release in the rabbit carotid body chemoreceptor cells. ( Almaraz, L; Gonzalez, C; Rocher, A, 1999)
"In both laryngeal squamous cell carcinoma xenograft tumour lines carbogen was very effective in reducing diffusion limited hypoxia."	3.70	Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide. ( Bussink, J; Hodgkiss, RJ; Kaanders, JH; Marres, HA; Peters, JP; Rijken, PF; van der Kogel, AJ, 1999)
"1 To investigate the effect of moderate hypoxia alone or combined with an inflammatory reaction or after 3-methylcholanthrene (3MC) pre-treatment on cytochrome P450 (P450), conscious rabbits were exposed for 24 h to a fractional concentration of inspired O2 of 10% (mean PaO2 of 34 mmHg)."	3.70	Effect of hypoxia alone or combined with inflammation and 3-methylcholanthrene on hepatic cytochrome P450 in conscious rabbits. ( Bélanger, PM; Dalkara, S; El-Kadi, AO; Kurdi, J; Maurice, H; Ong, H; Souich, P, 1999)
"We have used the isolated brainstem-spinal cord preparation of the neonatal rat to study the effects of theophylline on the ventilatory response to hypoxia."	3.69	Theophylline and hypoxic ventilatory response in the rat isolated brainstem-spinal cord. ( Kawai, A; Mückenhoff, K; Okada, Y; Scheid, P, 1995)
" Adenosine-receptor blockade with 8-(p-sulfophenyl)-theophylline reduced by 50% the maximum hypoxia-induced rise in plasma ANP concentrations."	3.69	Adenosine modulates hypoxia-induced atrial natriuretic peptide release in fetal sheep. ( Arora, CP; Castro, LC; Koos, BJ; Mason, BA; Ogunyemi, DA, 1995)
"In two groups of Saffan-anaesthetized, spontaneously breathing rats we have attempted to identify the peripheral influences of adenosine in mediating the responses evoked by hypoxia by using an adenosine receptor antagonist, 8-sulphophenyltheophylline (8-SPT, 20 mg kg-1 i."	3.69	Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia. ( Elnazir, BK; Marshall, JM; Thomas, T, 1994)
" In ten spontaneously breathing, Saffan-anaesthetized rats (group I), respiratory and cardiovascular responses evoked by 10 min periods of hypoxia (arterial partial pressure of O2, Pa,O2, 33 mmHg) were recorded before and after the administration of the adenosine receptor antagonist 8-phenyltheophylline (8-PT, 10 mg kg-1 i."	3.69	Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. ( Marshall, JM; Thomas, T, 1994)
" The effects of NG-monomethyl-L-arginine, tetrodotoxin and glibenclamide on hypoxia-induced coronary artery relaxation, induced by bubbling Krebs solution with 95% N2 and 5% CO2 instead of 95% O2 and 5% CO2, were assessed by measuring the changes in isometric tension in isolated epicardial coronary artery rings of the rabbit."	3.69	Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. ( Collins, P; Jiang, C, 1994)
"The role of intracerebral adenosine levels in the control of ventilatory response to hypoxia was explored in 15 spontaneously breathing intubated piglets, 1-5 days old, sedated with chloral hydrate."	3.69	Role of adenosine in the hypoxic ventilatory response of the newborn piglet. ( Aranda, JV; Davis, GM; Lopes, JM; Mullahoo, K, 1994)
"To elucidate the role of adenosine in coronary vasoregulation, we studied the effects of adenosine antagonism (by theophylline) on coronary blood flow at different levels of adenosine formation (stimulated by hypoxia and exercise)."	3.69	Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation. ( Edlund, A; Sollevi, A, 1995)
" In Saffan-anaesthetized rats, we have further investigated the mechanisms underlying the vasodilatation induced by adenosine in skeletal muscle by acute systemic hypoxia (breathing 8% O2 for 5 min)."	3.69	Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. ( Marshall, JM; Skinner, MR, 1996)
"This study was performed to assess whether nifedipine could prevent the decrease in hepatic cytochrome P450 induced by acute moderate hypoxia or an inflammatory reaction."	3.69	Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction. ( Barakat, M; du Souich, P, 1996)
" They were studied under anaesthesia while breathing 12% O2 and during acute hypoxia (breathing 8% O2 for 5 min) before and after addition of the adenosine receptor antagonist 8-phenyltheophylline (8-PT, 10 mg kg-1)."	3.69	The roles of adenosine in regulating the respiratory and cardiovascular systems in chronically hypoxic, adult rats. ( Marshall, JM; Thomas, T, 1997)
"In electrically driven myocardial preparations obtained from chronically methylxanthine-[aminophylline (APH) and 8-phenyltheophylline (8-PT)] or solvent(DMSO)-treated guinea pigs no differences were found in alteration of mechanical activity under hypoxia and reoxygenation."	3.69	Long-lasting treatment with adenosine receptor antagonists: effects on hypoxic tolerance and vascular responsiveness. ( Antal, K; Cseppentö, A; Kovács, P; Szabó, JZ; Szegi, J; Szentmiklósi, AJ; Ujfalusi, A, 1996)
" In 10-day-old rats, mucosal permeability to 51Cr EDTA was measured after subjecting the animals to 10-minute ischemia-reperfusion injury, 30 minutes of hypoxia (14% oxygen), cold stress (4 degree C for 4 minutes), and intraperitoneal indomethacin (0."	3.68	Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs. ( Langer, JC; Mumford, DA; Sohal, SS, 1993)
" The rate and amplitude of smooth muscle relaxation at low PO2 were significantly decreased by tolbutamide (5 mmol l-1), which is known to inhibit cyclic AMP-dependent protein kinases."	3.68	Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats. ( Basilyuk, OV; Soloviev, AI, 1993)
"The purpose of this study was twofold: 1) to verify a report that a suspension of 8-phenyltheophylline (8-PT) completely abolished hypoxia-induced coronary vasodilation [H."	3.68	Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline. ( Downey, HF; Lee, SC; Mallet, RT; Shizukuda, Y; Williams, AG, 1992)
"Endogenous adenosine depresses synaptic transmission in rat hippocampal slices during periods of hypoxia, a potentially neuroprotective cellular response that is attenuated by the adenosine antagonist 8-cyclopentyltheophylline."	3.68	Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist: an anatomical and behavioral study. ( Boissard, CG; Gribkoff, VK; Lindner, MD, 1992)
"The present studies were undertaken to assess the direct effects of N6-cyclohexyladenosine (CHA), a stable adenosine analogue, on erythropoietin (Ep) secretion in hepatocellular carcinoma cells (Hep 3B)."	3.68	Increased erythropoietin secretion in human hepatoma cells by N6-cyclohexyladenosine. ( Beckman, B; Brookins, J; Fisher, JW; Nakashima, J, 1991)
" In rats anaesthetized with Saffan we have studied the effects of the adenosine receptor antagonists, theophylline and 8-phenyltheophylline, upon the respiratory and cardiovascular responses evoked by 5 min periods of systemic hypoxia."	3.68	The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat. ( Marshall, JM; Neylon, M, 1991)
"Arousal is an important protective mechanism that aids in the resolution of obstructive sleep apnea in adults and children, but its role in neonatal apnea has not been investigated."	3.68	Behavioral arousal in newborn infants and its association with termination of apnea. ( Belan, MA; Cowen, CP; Mathew, OP; Thoppil, CK, 1991)
"These results show that adenosine does play a role in hypoxia induced bradycardia and vagal potentiation."	3.68	Endogenous adenosine enhances vagal negative chronotropic effect during hypoxia in the anaesthetised rabbit. ( Borgdorff, P; Verlato, G, 1990)
"The role of adenosine in hypoxia-induced vasodilation was examined in the intestine of pentobarbital sodium-anesthetized cats."	3.68	Hypoxia-induced vasodilation of the feline superior mesenteric artery is not adenosine mediated. ( Lautt, WW; Lockhart, LK, 1990)
"This study investigated the role of adenosine in the regulation of neonatal cerebral blood flow (CBF) during moderate (arterial PO2 = 47 +/- 9 Torr) and severe (arterial PO2 = 25 +/- 4 Torr) hypoxia."	3.68	Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet. ( Aranda, JV; Beharry, K; Farri, E; Laudignon, N; Rex, J, 1990)
"Previous studies suggest that high levels of adenosine may enhance histamine release and contribute to atrioventricular (AV) nodal conduction arrhythmias during anaphylaxis of isolated guinea pig hearts."	3.67	Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts. ( Heller, LJ; Regal, JF; Trachte, GJ, 1989)
"Anesthetized randomsource mongrel dogs of either sex were instrumented to investigate the effects of 8-phenyltheophylline on changes in coronary perfusion pressure caused by systemic hypoxia under conditions of controlled constant coronary blood flow."	3.67	Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline. ( Kang, YH; Merrill, GF; Wei, HM, 1989)
"The present study addressed the hypothesis that cardiac production of adenosine (ADO) and/or prostacyclin (PGI2) during hypoxia is augmented to a level sufficient to affect nerve-stimulation-induced release of noradrenaline (NA)."	3.67	Effect of hypoxia on nerve-stimulation-induced release of noradrenaline from the rabbit heart. ( Wennmalm, M, 1988)
"The purpose of the present study was to elucidate the importance of extracellular adenosine (ADO) in the regulation of cerebrocortical microcirculation during rest, hypoxia, and brain activation."	3.67	Effect of theophylline treatment on the functional hyperaemic and hypoxic responses of cerebrocortical microcirculation. ( Dóra, E, 1986)
"In conclusion, our results suggest that neither the redox state of cytochrome oxidase nor adenosine are critical factors in the regulation of cerebral blood flow during arterial hypoxia and epileptic seizures."	3.67	Regulation of cerebral blood flow (CBF) during hypoxia and epileptic seizures. ( Dóra, E; Kovách, AG, 1985)
"5 months but who was equipped with an apnea monitor at home on psychological indications."	3.66	A case of near-miss SIDS developing an abnormal respiratory reaction to hypoxia. ( Bjure, J; Kjellmer, I; Wennergren, G, 1983)
" Alterations in coronary flow were induced by hypoxia, amobarbital (Amytal) infusion, increase in work load of the heart, and adenosine infusion."	3.66	Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. ( Erecińska, M; Nishiki, K; Nuutinen, EM; Wilson, DF, 1982)
"Previous studies using bioassay demonstrated the presence of a vasoactive substance or substances in coronary sinus blood during myocardial reactive hyperemia which had, on bioassay, characteristics of adenosine and/or AMP."	3.66	Evidence from bioassay studies indicating a role for adenosine in cardiac ischemic and hypoxic dilation in the dog. ( Chen, WT; Dabney, JM; Haddy, FJ; Scott, JB; Swindall, BT, 1979)
" Theophylline (10(-4) M) inhibits both hypoxia and adenosine effects."	3.65	[The effect of hypoxia on the branchial vascular system of the perfused trout head]. ( Laurent, P; Ristori, MT, 1977)
" The increased beta-adrenergic activity thus generated was associated with marked reductions in the pulmonary vasoconstrictor responses to hypoxia, hypercapnic acidosis, and histamine, but not to serotonin."	3.65	beta-Receptor influence on lung vasoconstrictor responses to hypoxia and humoral agents. ( Bergofsky, EH; Naftchi, NE; Porcelli, RJ; Viau, AT, 1977)
" Values for elimination half-life (7."	2.66	Theophylline clearance in patients with severe chronic obstructive pulmonary disease receiving supplemental oxygen and the effect of acute hypoxemia. ( Charan, NB; Crowley, JJ; Cusack, BJ; Mercer, GD; Vestal, RE, 1986)
"Medications partially improve obstructive sleep apnea and stabilize periodic breathing at altitude."	2.50	Medication effects on sleep and breathing. ( Lee-Chiong, T; Seda, G; Tsai, S, 2014)
"Theophylline is a bronchodilator used extensively in the management of obstructive pulmonary disease."	2.38	Hypoxia, arterial pH and theophylline disposition. ( Lam, YW; Richer, M, 1993)
"Aminophylline has been shown to reduce severe renal dysfunction in neonates after perinatal asphyxia."	1.62	Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia. ( Cho, SH; Chock, VY; Frymoyer, A, 2021)
"Thus β(2)-agonists reduce the anoxia-induced loss of force, leading to partial force recovery."	1.38	Effects of β₂-agonists on force during and following anoxia in rat extensor digitorum longus muscle. ( Clausen, T; Fredsted, A; Gissel, H; Ortenblad, N, 2012)
" We conclude that concomitant dosing with a cardiac stimulant and endothelin antagonist can partially reverse loss of physical performance capacity under hypobaric hypoxia, independent from improving blood oxygen saturation."	1.38	The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude. ( Boico, A; Hamilton, K; Hanna, G; Irwin, D; Palmer, G; Piantadosi, CA; Radiloff, DR; Schroeder, T; Shan, S; Wu, C; Zhao, Y, 2012)
"Adenosine serves as a homeostatic factor, regulating hippocampal activity through A(1) receptor-mediated inhibition."	1.35	Modulation of gamma oscillations by endogenous adenosine through A1 and A2A receptors in the mouse hippocampus. ( Hamilton, JB; Lancaster, DM; Patel, N; Pietersen, AN; Vreugdenhil, M, 2009)
"We investigated DA balance during early anoxia when energy status in the turtle brain is compromised."	1.33	Adenosine and ATP-sensitive potassium channels modulate dopamine release in the anoxic turtle (Trachemys scripta) striatum. ( Lutz, PL; Milton, SL, 2005)
"The acute renal effects of hypoxemia and the ability of the co-administration of an angiotensin converting enzyme inhibitor (perindoprilat) and an adenosine receptor antagonist (theophylline) to prevent these effects were assessed in anesthetized and mechanically-ventilated rabbits."	1.31	Complementary effects of adenosine and angiotensin II in hypoxemia-induced renal dysfunction in the rabbit. ( Gouyon, JB; Guignard, JP; Huet, F; Prévot, A; Semama, DS, 2002)
"Adenosine dilation was also blunted by glibenclamide, a KATP antagonist (9 +/- 2, 14 +/- 3, 21 +/- 4 vs."	1.30	Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation. ( Armstead, WM, 1997)
"Levels increased during anoxia, during hypercapnia, and to an even greater extent during anoxic hypercapnia."	1.30	A role for adenosine in metabolic depression in the marine invertebrate Sipunculus nudus. ( Nilsson, GE; Pörtner, HO; Reipschläger, A, 1997)
"Post-theophylline HPV was divided by pre-theophylline HPV to normalize individual variation."	1.30	Effect of theophylline on hypoxic pulmonary vasoconstriction in awake rats. ( Arisaka, Y; Kato, S; Sato, S; Takahashi, H; Tomoike, H; Yuki, H, 1997)
"In theophylline-treated animals, NMDA responses were completely abolished during hypoxia (28 +/- 2 vs."	1.30	Inhibitory effects of hypoxia and adenosine on N-methyl-D-aspartate-induced pial arteriolar dilation in piglets. ( Bari, F; Busija, DW; Louis, TM; Thore, CR, 1998)
"According to the anoxemia theory of atherosclerosis, an imbalance between the demand for and supply of oxygen and nutrients in the arterial wall is a key factor in atherogenesis."	1.30	A bioluminescence method for the mapping of local ATP concentrations within the arterial wall, with potential to assess the in vivo situation. ( Björnheden, T; Evaldsson, M; Levin, M; Walenta, S; Wiklund, O, 1999)
"Pentoxifylline is a noteworthy drug that could be a candidate as a therapy to help prevent hypoxemia in lung injuries that share a common mechanism with oleic acid-induced lung injury."	1.29	Pentoxifylline prevents a decrease in arterial oxygen tension in oleic acid-induced lung injury. ( Moriuchi, H; Yuizono, T, 1995)
"In vitro cultures of an Epo producing hepatocellular carcinoma (Hep3B) cell line with NECA (> or = 10(-6) M) for 20 hours under hypoxic conditions (1% O2) produced significant increases in medium levels of Epo when compared with hypoxia controls."	1.29	Effects of 5'-N-ethylcarboxamideadenosine (NECA) on erythropoietin production. ( Agrawal, KC; Beckman, BS; Brookins, JW; Fisher, JW; Nakashima, J; Ohigashi, T, 1993)
"During anoxia, however, these antagonists provoked maximal efflux of K+ (anoxic depolarization)."	1.29	Adenosine, a "retaliatory" metabolite, promotes anoxia tolerance in turtle brain. ( Lutz, PL; Pérez-Pinzón, MA; Rosenthal, M; Sick, TJ, 1993)
"Treatment with theophylline did not alter the elevation of plasma [ADO] after dipyridamole infusion, but abolished responses of fetal heart rate to dipyridamole infusion."	1.28	Plasma adenosine and cardiovascular responses to dipyridamole in fetal sheep. ( Power, GG; Yoneyama, Y, 1992)
"The therapy of pulmonary hypertension is difficult in those diseases where the causes or mechanisms are not understood or are unknown."	1.27	Treatment of pulmonary hypertension. ( Denolin, H; Mathey, DG, 1986)
"The acute renal effects of hypoxemia and the ability of theophylline to prevent these effects were assessed in anesthetized and mechanically-ventilated newborn and adult rabbits."	1.27	Theophylline prevents the hypoxemia-induced renal hemodynamic changes in rabbits. ( Gouyon, JB; Guignard, JP, 1988)
" In both Groups I and II, our aminophylline dosage schedules, which consisted of intravenously administered boluses of 6 and 3 mg/kg followed by constant infusions of 1 mg/kg/h, resulted in serum theophylline levels that ranged from 12."	1.26	Aminophylline does not inhibit canine hypoxic pulmonary vasoconstriction. ( Benumof, JL; Trousdale, FR, 1982)
"In the "anoxia test" the anoxic tolerance was shortened by AR-L 115 BS similar to theophylline when the anoxic contractile activity was stimulated below the maximum level in contrast to the prolongation due to ouabain."	1.26	[The effect of AR-L 115 BS on the function and oxygen consumption of isolated guinea pig atria as compared to g-strophanthin and theophylline]. ( Seifart, HJ; Siess, M; Stieler, K, 1981)
"The effects of acute and chronic hypoxemia on norepinephrine-stimulated lipolysis were studied in dogs."	1.26	Norepinephrine-stimulated lipolysis in acute and chronic hypoxemia. ( Baum, D; Oyer, P, 1981)
" The dose-response and time-action parameters of theophylline's predisposing action to chloroform-hypoxia-induced cardiac arrhythmias were determined."	1.26	Development of a cardiac antiarrhythmic screening test utilizing theophylline in the rat. ( Baker, T; Erker, EF, 1980)
"In puppies with oxygen deficiency, insulin levels declined, whereas during epinephrine infusion, they remained stable or increased slightly."	1.26	Beta adrenergic receptor dysfunction in hypoxic inhibition of insulin release. ( Baum, D; Porte, D, 1976)

Research

Studies (189)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Max Creatinine

Timeframe	Studies, this research(%)	All Research%
pre-1990	77 (40.74)	18.7374
1990's	75 (39.68)	18.2507
2000's	27 (14.29)	29.6817
2010's	7 (3.70)	24.3611
2020's	3 (1.59)	2.80

Authors	Studies
Boylan, PM	1
Abdalla, M	1
Bissell, B	1
Malesker, MA	1
Santibañez, M	1
Smith, Z	1
Subudhi, AW	1
Evero, O	1
Reitinger, J	1
Davis, C	1
Gronewold, J	1
Nichols, AJ	1
Van-Houten, SJ	1
Roach, RC	1
Chock, VY	1
Cho, SH	1
Frymoyer, A	1
Seda, G	1
Tsai, S	1
Lee-Chiong, T	1
Efrati, S	1
Berman, S	1
Ilgiyeav, I	1
Siman-Tov, Y	1
Averbukh, Z	1
Weissgarten, J	1
Pietersen, AN	1
Lancaster, DM	1
Patel, N	1
Hamilton, JB	1
Vreugdenhil, M	1
Coney, AM	3
Marshall, JM	13
George, EM	1
Cockrell, K	1
Adair, TH	1
Granger, JP	1
Henderson-Smart, DJ	1
De Paoli, AG	1
Fredsted, A	1
Gissel, H	1
Ortenblad, N	1
Clausen, T	1
Radiloff, DR	1
Zhao, Y	1
Boico, A	1
Wu, C	1
Shan, S	1
Palmer, G	1
Hamilton, K	1
Irwin, D	1
Hanna, G	1
Piantadosi, CA	1
Schroeder, T	1
Chen, XY	1
Zeng, YM	1
Zhang, YX	1
Wang, WY	1
Wu, RH	1
Kyung Park, Y	1
Jun Jung, S	1
Kwak, J	1
Kim, J	1
Ray, CJ	1
Abbas, MR	1
Kulinskii, VI	1
Minakina, LN	1
Gavrilina, TV	1
Lobner, D	1
Mitrouska, I	1
Kondili, E	1
Prinianakis, G	1
Siafakas, N	1
Georgopoulos, D	1
Fowler, JC	2
Gervitz, LM	2
Hamilton, ME	1
Walker, JA	1
Davies, DG	1
Omidvar, K	1
Tsantes, AE	1
Tassiopoulos, ST	1
Papadhimitriou, SI	1
Bonovas, S	1
Poulakis, N	1
Vlachou, A	1
Filioussi, K	1
Loukopoulos, D	1
MULLER, R	1
SCHILD, W	1
REICHERTZ, P	1
Martín, ED	1
González-García, C	1
Milán, M	1
Fariñas, I	1
Ceña, V	1
Streit, M	1
Göggelmann, C	1
Dehnert, C	1
Burhenne, J	1
Riedel, KD	1
Menold, E	1
Mikus, G	1
Bärtsch, P	1
Haefeli, WE	1
Milton, SL	1
Lutz, PL	2
Lee, SD	1
Nakano, H	2
Farkas, GA	1
Arrigoni, E	1
Crocker, AJ	1
Saper, CB	1
Greene, RW	1
Scammell, TE	1
Agnisola, C	1
Ariel, M	1
Walsh, MP	1
MacCormack, TJ	1
Driedzic, WR	1
Singh, A	1
Ferrero, ME	1
Marni, A	1
Gaja, G	1
Rugarli, C	1
Marini, JJ	1
Bukowskyj, M	1
Nakatsu, K	2
Munt, PW	1
Simson, JN	1
Merhav, A	1
Silen, W	1
Millhorn, DE	1
Eldridge, FL	1
Kiley, JP	1
Waldrop, TG	1
O'Donnell, TV	1
Wennergren, G	1
Bjure, J	1
Kjellmer, I	1
Brenner, G	2
Letarte, L	1
du Souich, P	4
Sanders, JS	1
Berman, TM	1
Bartlett, MM	1
Kronenberg, RS	1
Rigatto, H	2
Desai, U	1
Leahy, F	1
Kalapesi, Z	1
Cates, D	1
Snow, TR	1
Caspar, T	1
Stowe, DF	1
Nuutinen, EM	1
Nishiki, K	1
Erecińska, M	1
Wilson, DF	1
Benumof, JL	1
Trousdale, FR	1
Siess, M	1
Stieler, K	1
Seifart, HJ	1
Baum, D	2
Oyer, P	1
Erker, EF	1
Baker, T	1
Reid, JM	1
Davies, AG	1
Ashcroft, FM	1
Paterson, DJ	1
Kawai, A	1
Okada, Y	1
Mückenhoff, K	1
Scheid, P	1
Ogunyemi, DA	1
Koos, BJ	3
Arora, CP	1
Castro, LC	1
Mason, BA	2
Sawanobori, T	1
Adaniya, H	1
Yukisada, H	1
Hiraoka, M	1
Igarashi, T	1
Nishimura, M	2
Kobayashi, S	2
Miyamoto, K	2
Kawakami, Y	2
Mellemkjaer, S	1
Nielsen-Kudsk, JE	1
Thomas, T	6
Elnazir, BK	1
Nakhostine, N	1
Lamontagne, D	1
Hara, A	1
Abiko, Y	1
Moriuchi, H	1
Yuizono, T	1
Zhu, PJ	2
Krnjević, K	2
Jiang, C	1
Collins, P	1
Dini, FL	1
Pasini, G	1
Cortellini, G	1
Cani, E	1
Bettini, R	1
Garagnani, A	1
Gobbi, G	1
Greco, A	1
Onorato, G	1
Pasini, P	1
Adén, U	1
Lindström, K	1
Bona, E	1
Hagberg, H	1
Fredholm, BB	1
Lopes, JM	1
Davis, GM	1
Mullahoo, K	1
Aranda, JV	2
Turner, L	1
Yamamoto, M	1
Akiyama, Y	1
Walker, DM	1
Marber, MS	1
Walker, JM	1
Yellon, DM	1
Yamashiro, Y	1
Kryger, MH	1
Nakashima, J	2
Ohigashi, T	1
Brookins, JW	1
Beckman, BS	1
Agrawal, KC	1
Fisher, JW	4
Richer, M	1
Lam, YW	1
Langer, JC	1
Sohal, SS	1
Mumford, DA	1
Katchman, AN	1
Hershkowitz, N	1
Ervin, MG	1
Pérez-Pinzón, MA	1
Sick, TJ	1
Rosenthal, M	1
Soloviev, AI	1
Basilyuk, OV	1
Cohen, MV	1
Walsh, RS	1
Goto, M	1
Downey, JM	1
Chau, A	1
Ogunyemi, D	1
Porras, H	1
Meehan, B	1
Côté, A	1
Edlund, A	1
Sollevi, A	2
Croning, MD	1
Zetterström, TS	1
Grahame-Smith, DG	1
Newberry, NR	1
Gershan, WM	1
Forster, HV	1
Lowry, TF	1
Garber, AK	1
Skinner, MR	1
Barakat, M	1
Matherne, GP	1
Berr, SS	1
Headrick, JP	1
Armstead, WM	1
Elnazir, B	1
Kumar, P	1
Griffiths, TL	2
Christie, JM	2
Parsons, ST	2
Holgate, ST	2
Reipschläger, A	1
Nilsson, GE	1
Pörtner, HO	1
Broadley, KJ	1
Maddock, HL	1
Khan, Y	1
Heckmatt, JZ	1
Cseppentö, A	1
Ujfalusi, A	1
Antal, K	1
Szegi, J	1
Szabó, JZ	1
Kovács, P	1
Szentmiklósi, AJ	1
Gleiter, CH	2
Brause, M	1
Delabar, U	1
Zebski, H	1
Eckardt, KU	1
Becker, T	1
Wenzel, J	1
Arisaka, Y	1
Sato, S	1
Kato, S	1
Yuki, H	1
Takahashi, H	1
Tomoike, H	1
Bari, F	2
Louis, TM	2
Busija, DW	2
Webster, L	1
Hodgkiss, RJ	2
Wilson, GD	1
Thore, CR	1
Tani, M	1
Suganuma, Y	1
Takayama, M	1
Hasegawa, H	1
Shinmura, K	1
Ebihara, Y	1
Tamaki, K	1
Gautier, H	1
Murariu, C	1
du Preez, MJ	1
Botha, JH	1
McFadyen, ML	1
Adhikari, M	1
Rocher, A	1
Gonzalez, C	1
Almaraz, L	1
Björnheden, T	2
Levin, M	2
Evaldsson, M	2
Wiklund, O	2
Walenta, S	1
Bussink, J	1
Kaanders, JH	1
Rijken, PF	1
Peters, JP	1
Marres, HA	1
van der Kogel, AJ	1
Kurdi, J	1
Maurice, H	1
El-Kadi, AO	1
Ong, H	1
Dalkara, S	1
Bélanger, PM	1
Souich, P	1
Delaey, C	1
Boussery, K	1
Van de Voorde, J	1
Giussani, DA	1
Gardner, DS	1
Cox, DT	1
Fletcher, AJ	1
Grunstein, RR	1
Hedner, J	1
Grote, L	1
Höhne, C	1
Krebs, MO	1
Boemke, W	1
Arntz, E	1
Kaczmarczyk, G	1
Goirand, F	1
Bardou, M	1
Dumas, J	1
Rochette, L	1
Dumas, M	1
Osanai, S	1
Takahashi, T	1
Enomoto, H	1
Satoh, N	1
Yahara, O	1
Akiba, Y	1
Fujiuchi, S	1
Ohsaki, Y	1
Kikuchi, K	1
Prévot, A	1
Huet, F	1
Semama, DS	1
Gouyon, JB	2
Guignard, JP	2
Ferrara, A	1
Numeroso, R	1
Santerni, N	1
Fumagalli, G	1
Ristori, MT	1
Laurent, P	1
Rodgers, GM	1
George, WJ	1
Hammers, R	1
Clarenbach, P	1
Lindl, T	1
Cramer, H	1
Crass, MF	1
Mahmood, T	1
Vishwanath, S	1
Porcelli, RJ	1
Viau, AT	1
Naftchi, NE	1
Bergofsky, EH	1
Carlisle, KS	1
Chew, CS	1
Hersey, SJ	1
Benzi, G	1
Haddy, FJ	2
Scott, JB	1
Chen, WT	1
Swindall, BT	1
Dabney, JM	1
Budmiger, H	1
Kyd, K	1
Scherrer, M	1
Lucey, JF	1
Porte, D	2
Thoresen, M	1
Dahlin, I	1
Lundberg, JM	1
Lagercrantz, H	1
Yoneyama, Y	1
Power, GG	1
Swaminathan, S	1
Paton, JY	1
Ward, SL	1
Sargent, CW	1
Keens, TG	1
Lee, SC	1
Mallet, RT	1
Shizukuda, Y	1
Williams, AG	1
Downey, HF	1
Boissard, CG	1
Lindner, MD	1
Gribkoff, VK	1
Brookins, J	2
Beckman, B	2
von Beckerath, N	1
Cyrys, S	1
Dischner, A	1
Daut, J	1
Neylon, M	1
Thoppil, CK	1
Belan, MA	1
Cowen, CP	1
Mathew, OP	1
Verlato, G	1
Borgdorff, P	1
Lockhart, LK	1
Lautt, WW	1
Laudignon, N	1
Farri, E	1
Beharry, K	1
Rex, J	1
Hoen, B	1
Saunier, C	2
Hartemann, D	2
Sautegeau, A	2
Cornette, A	1
Delorme, N	1
Polu, JM	1
Sadoul, P	1
Heller, LJ	1
Trachte, GJ	1
Regal, JF	1
Kishimoto, I	1
Tanigawara, Y	1
Okumura, K	1
Hori, R	1
Lejeune, P	1
Leeman, M	1
Mélot, C	1
Naeije, R	1
Wei, HM	1
Kang, YH	1
Merrill, GF	1
Denolin, H	1
Mathey, DG	1
Crenesse, D	2
Berre, A	2
Ardisson, JL	2
Blaive, B	2
McQueen, DS	1
Ribeiro, JA	1
Morii, S	1
Ngai, AC	1
Ko, KR	1
Winn, HR	1
Wennmalm, M	1
Bowton, DL	1
Haddon, WS	1
Prough, DS	1
Adair, N	1
Alford, PT	1
Stump, DA	1
Ueno, M	1
Haller, C	1
Kuschinsky, W	1
Ebden, P	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Pharmacokinetics (PK) and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia[NCT05295784]	Phase 1	18 participants (Anticipated)	Interventional	2024-06-30	Not yet recruiting
Attenuation of Myocardial Dysfunction by N-Acetylcysteine in Infants Undergoing Arterial Switch Procedure[NCT00374088]	Phase 2	21 participants (Actual)	Interventional	2005-02-28	Completed
The Effect of Aminophylline on Preventing Acute Kidney Injury in Pediatric Patients Undergoing Open Heart Surgery[NCT03897335]	Phase 3	80 participants (Anticipated)	Interventional	2019-02-07	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Maximum serum creatinine over first 3 days postoperative. (NCT00374088)
Timeframe: 72 hours

Maximum Decline in Measured Cardiac Output

Intervention	mg/dL (Mean)
Placebo	0.99
N-acetylcysteine	0.74

Serial cardiac output was measured by thermodilution. The outcome of maximum decline in indexed cardiac output from 1 hour postoperative to lowest output within 24 hours postoperative was then calculated and compared between NAC and placebo groups. (NCT00374088)
Timeframe: 24 hours

Urine Output

Intervention	L/min/m2 (Mean)
Placebo	0.68
N-acetylcysteine	0.29

Total urine output over the first 24 hours postoperative (NCT00374088)
Timeframe: 24 hours

Article	Year
Theophylline for the management of respiratory disorders in adults in the 21st century: A scoping review from the American College of Clinical Pharmacy Pulmonary Practice and Research Network. Pharmacotherapy, 2023, Volume: 43, Issue:9 Topics: Adult; Asthma; Bronchodilator Agents; Humans; Hypoxia; Pharmacy; Pulmonary Disease, Chronic Obstruct	2023
Medication effects on sleep and breathing. Clinics in chest medicine, 2014, Volume: 35, Issue:3 Topics: Acetazolamide; Altitude; Androgens; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Be	2014
Prophylactic methylxanthine for prevention of apnoea in preterm infants. The Cochrane database of systematic reviews, 2010, Dec-08, Issue:12 Topics: Apnea; Bradycardia; Caffeine; Central Nervous System Stimulants; Humans; Hypoxia; Infant, Newborn; I	2010
Role of nitric oxide in the control of coronary resistance in teleosts. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2005, Volume: 142, Issue:2 Topics: Adenosine; Animals; Arginine; Coronary Circulation; Electrodes; Fishes; Guanylate Cyclase; Heart; Hy	2005
Theophylline reassessed. Annals of internal medicine, 1984, Volume: 101, Issue:1 Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents;	1984
Review: sleep in heart failure. Sleep, 1993, Volume: 16, Issue:6 Topics: Carbon Dioxide; Cerebrovascular Circulation; Cheyne-Stokes Respiration; Comorbidity; Electroencephal	1993
Hypoxia, arterial pH and theophylline disposition. Clinical pharmacokinetics, 1993, Volume: 25, Issue:4 Topics: Acid-Base Imbalance; Animals; Dogs; Humans; Hydrogen-Ion Concentration; Hypoxia; Lung Diseases; Mice	1993
Treatment options for sleep apnoea. Drugs, 2001, Volume: 61, Issue:2 Topics: Acetazolamide; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Humans; Hypoxia; Positive-	2001
The role of renal adenosine 3',5'-monophosphate in the control of erythropoietin production. The American journal of medicine, 1975, Volume: 58, Issue:1 Topics: Adenine Nucleotides; Adenylyl Cyclases; Animals; Bucladesine; Cobalt; Cyclic AMP; Cyclic GMP; Enzyme	1975
Bioassay and pharmacologic evaluation of the adenosine hypothesis. Advances in experimental medicine and biology, 1977, Volume: 78 Topics: Adenosine; Adenosine Monophosphate; Animals; Biological Assay; Coronary Circulation; Hyperemia; Hypo	1977
Apnea and periodic breathing. Seminars in perinatology, 1977, Volume: 1, Issue:4 Topics: Apnea; Carbon Dioxide; Cheyne-Stokes Respiration; Humans; Hypoxia; Infant, Newborn; Infant, Prematur	1977
Cardiovascular effects of adenosine in man; possible clinical implications. Progress in neurobiology, 1986, Volume: 27, Issue:4 Topics: Adenosine; Cardiovascular Diseases; Cardiovascular System; Humans; Hypoxia; Ischemia; Purines; Recep	1986
Status asthmaticus. Chest, 1985, Volume: 87, Issue:1 Suppl Topics: Adolescent; Adult; Aged; Asthma; Atropine; Bronchi; Bronchoscopy; Child; Child, Preschool; Fluid The	1985
[Is adenosine the mediator for the regulation of the coronary circulation and for the effect of coronarodilators? Review]. Die Pharmazie, 1974, Volume: 29, Issue:9 Topics: Adenosine; Adenosine Triphosphate; Aminohydrolases; Aminophylline; Animals; Calcium; Carbon Dioxide;	1974
Control of insulin secretion by catecholamines, stress, and the sympathetic nervous system. Federation proceedings, 1973, Volume: 32, Issue:7 Topics: Animals; Caffeine; Catecholamines; Cyclic AMP; Diazoxide; Epinephrine; Glucose; Hypothermia; Hypoxia	1973

Article	Year
Effects of theophylline on ventilatory poststimulus potentiation in patients with brain damage. American journal of respiratory and critical care medicine, 2003, Apr-15, Volume: 167, Issue:8 Topics: Double-Blind Method; Humans; Hyperoxia; Hypoxia; Hypoxia, Brain; Pulmonary Ventilation; Theophylline	2003
Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m). European journal of clinical pharmacology, 2005, Volume: 61, Issue:1 Topics: Adult; Altitude; Area Under Curve; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CY	2005
Dependency on the rate of change in PaO2 of the ventilatory response to progressive hypoxia. American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:6 Topics: Adenosine; Adult; Chemoreceptor Cells; Cross-Over Studies; Humans; Hypoxia; Male; Oxygen; Partial Pr	1995
Methylxanthine drug therapy in chronic heart failure associated with hypoxaemia: double-blind placebo-controlled clinical trial of doxofylline versus theophylline and bamifylline. International journal of clinical pharmacology research, 1993, Volume: 13, Issue:6 Topics: Aged; Double-Blind Method; Echocardiography; Female; Heart; Heart Failure; Heart Rate; Humans; Hypox	1993
Role of endogenous adenosine in hypoxic ventilatory response in humans: a study with dipyridamole. Journal of applied physiology (Bethesda, Md. : 1985), 1994, Volume: 76, Issue:1 Topics: Adenosine; Adult; Carbon Dioxide; Dipyridamole; Double-Blind Method; Humans; Hypoxia; Infusions, Int	1994
The effect of dipyridamole and theophylline on hypercapnic ventilatory responses: the role of adenosine. The European respiratory journal, 1997, Volume: 10, Issue:1 Topics: Adenosine; Administration, Oral; Adult; Analysis of Variance; Bronchodilator Agents; Carbon Dioxide;	1997
A double blind cross over trial of theophylline prophylaxis for sleep hypoxaemia in Duchenne muscular dystrophy. Neuromuscular disorders : NMD, 1997, Volume: 7, Issue:2 Topics: Adolescent; Adult; Child; Double-Blind Method; Female; Humans; Hypoxia; Male; Muscular Dystrophies;	1997
Erythropoietin production in healthy volunteers subjected to controlled hypobaric hypoxia: further evidence against a role for adenosine. British journal of clinical pharmacology, 1997, Volume: 44, Issue:2 Topics: Adenosine; Adult; Area Under Curve; Atmosphere Exposure Chambers; Dipyridamole; Erythropoietin; Huma	1997
[The bronchospasmolytics salbutamol, fenoterol, terbutaline and reproterol. Their effects and side effects in asthmatics after inhalation with an electric nebulizer]. Schweizerische medizinische Wochenschrift, 1978, Aug-05, Volume: 108, Issue:31 Topics: Adult; Aged; Albuterol; Asthma; Bronchodilator Agents; Female; Fenoterol; Humans; Hypoxia; Male; Met	1978
Theophylline does not increase ventilatory responses to hypercapnia or hypoxia. The American review of respiratory disease, 1992, Volume: 146, Issue:6 Topics: Adult; Double-Blind Method; Female; Humans; Hypercapnia; Hypoxia; Male; Pulmonary Gas Exchange; Resp	1992
Effect of theophylline and dipyridamole on the respiratory response to isocapnic hypoxia in normal human subjects. Clinical science (London, England : 1979), 1991, Volume: 80, Issue:2 Topics: Adenosine; Adult; Carbon Dioxide; Computers; Dipyridamole; Double-Blind Method; Humans; Hypoxia; Mal	1991
[Value of theophylline in the prevention of postoperative hypoxemia in abdominal surgery]. Presse medicale (Paris, France : 1983), 1988, Feb-27, Volume: 17, Issue:7 Topics: Abdomen; Humans; Hypoxia; Postoperative Complications; Theophylline	1988
[Inefficacy of theophylline in preventing hypoxemia in abdominal surgery]. Cahiers d'anesthesiologie, 1988, Volume: 36, Issue:8 Topics: Abdomen; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypoxia; Male;	1988
Theophylline clearance in patients with severe chronic obstructive pulmonary disease receiving supplemental oxygen and the effect of acute hypoxemia. The American review of respiratory disease, 1986, Volume: 133, Issue:6 Topics: Administration, Oral; Aged; Humans; Hydrogen-Ion Concentration; Hypoxia; Injections, Intravenous; Lu	1986

Article	Year
Combined methazolamide and theophylline improves oxygen saturation but not exercise performance or altitude illness in acute hypobaric hypoxia. Experimental physiology, 2021, Volume: 106, Issue:1 Topics: Acute Disease; Adult; Altitude; Altitude Sickness; Cross-Over Studies; Double-Blind Method; Exercise	2021
Aminophylline for renal protection in neonatal hypoxic-ischemic encephalopathy in the era of therapeutic hypothermia. Pediatric research, 2021, Volume: 89, Issue:4 Topics: Acute Kidney Injury; Aminophylline; Asphyxia Neonatorum; Biomarkers; Creatinine; Female; Humans; Hyp	2021
Differential effects of N-acetylcysteine, theophylline or bicarbonate on contrast-induced rat renal vasoconstriction. American journal of nephrology, 2009, Volume: 29, Issue:3 Topics: Acetylcysteine; Animals; Contrast Media; Dinoprostone; Free Radical Scavengers; Hypoxia; Iothalamic	2009
Modulation of gamma oscillations by endogenous adenosine through A1 and A2A receptors in the mouse hippocampus. Neuropharmacology, 2009, Volume: 56, Issue:2 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Varianc	2009
Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. The Journal of physiology, 2010, Dec-15, Volume: 588, Issue:Pt 24 Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Bradycardia; Endothelium, Vascular; Female; H	2010
Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants. American journal of physiology. Regulatory, integrative and comparative physiology, 2010, Volume: 299, Issue:6 Topics: Adenosine; Animals; Chorionic Villi; Enzyme-Linked Immunosorbent Assay; Female; Hypoxia; Placenta; P	2010
Effects of β₂-agonists on force during and following anoxia in rat extensor digitorum longus muscle. Journal of applied physiology (Bethesda, Md. : 1985), 2012, Volume: 112, Issue:12 Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Animals; Bucladesine; Deoxyglucose; Electric Stimula	2012
The combination of theophylline and endothelin receptor antagonism improves exercise performance of rats under simulated high altitude. Journal of applied physiology (Bethesda, Md. : 1985), 2012, Oct-15, Volume: 113, Issue:8 Topics: Altitude; Animals; Arterial Pressure; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Synergism;	2012
Effect of chronic intermittent hypoxia on theophylline metabolism in mouse liver. Chinese medical journal, 2013, Volume: 126, Issue:1 Topics: Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Hepatocytes; Hypoxia; Liver; Male; Mice; M	2013
Effect of hypoxia on excitatory transmission in the rat substantia gelatinosa neurons. Biochemical and biophysical research communications, 2002, Jul-26, Volume: 295, Issue:4 Topics: Adenosine; Analgesics; Animals; Electrophysiology; Hypoxia; Neurons; Patch-Clamp Techniques; Phospho	2002
Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. The Journal of physiology, 2002, Oct-01, Volume: 544, Issue:Pt 1 Topics: Adenosine; Animals; Aorta; Cyclooxygenase Inhibitors; Diclofenac; Hypoxia; In Vitro Techniques; Indo	2002
Neuroprotective effect of hypoxic preconditioning: phenomenon and mechanisms. Bulletin of experimental biology and medicine, 2002, Volume: 133, Issue:2 Topics: Animals; Body Temperature; Female; Hypoxia; Ischemic Preconditioning; Male; Mice; Mice, Inbred C57BL	2002
Saturation of neuroprotective effects of adenosine in cortical culture. Neuroreport, 2002, Nov-15, Volume: 13, Issue:16 Topics: Adenosine; Animals; Cell Culture Techniques; Cell Death; Cerebral Cortex; Excitatory Amino Acid Agon	2002
Systemic hypoxia and the depression of synaptic transmission in rat hippocampus after carotid artery occlusion. The Journal of physiology, 2003, Aug-01, Volume: 550, Issue:Pt 3 Topics: Adenosine; Animals; Carotid Arteries; Cerebrovascular Circulation; Electrophysiology; Excitatory Pos	2003
The effect of acute hypoxemia and hypotension on adenosine-mediated depression of evoked hippocampal synaptic transmission. Experimental neurology, 2003, Volume: 182, Issue:2 Topics: Acute Disease; Adenosine; Animals; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Carotid	2003
Theophylline treatment may adversely affect the anoxia-induced erythropoietic response without suppressing erythropoietin production. European journal of clinical pharmacology, 2003, Volume: 59, Issue:5-6 Topics: Aged; Bronchodilator Agents; Cells, Cultured; Erythropoiesis; Erythropoietin; Female; Humans; Hypoxi	2003
[On the treatment of acute cerebral and cardiac blood circulation disorders]. Munchener medizinische Wochenschrift (1950), 1955, Aug-19, Volume: 97, Issue:33 Topics: Brain; Cardiac Glycosides; Cardiovascular Diseases; Heart; Humans; Hypoxia; Theophylline	1955
[THE EFFECT OF 7-(2-HYDROXY-3-(N-2-HYDROXYETHYL-N-METHYLAMINO)-PROPYL-THEOPHYLLINE NICOTINATE AND OTHER PURINE BODIES ON THE RESPIRATION AND ELECTROCARDIOGRAM OF GUINEA PIGS AND RATS IN HISTOTOXIC OXYGEN DEFICIENCY]. Arzneimittel-Forschung, 1963, Volume: 13 Topics: Cyanides; Electrocardiography; Guinea Pigs; Hypoxia; Niacin; Nicotinic Acids; Oxygen; Pharmacology;	1963
Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice. The European journal of neuroscience, 2004, Volume: 20, Issue:11 Topics: 4-Aminopyridine; Adenosine; alpha-Synuclein; Analgesics; Anesthetics, Local; Animals; Blotting, West	2004
Adenosine and ATP-sensitive potassium channels modulate dopamine release in the anoxic turtle (Trachemys scripta) striatum. American journal of physiology. Regulatory, integrative and comparative physiology, 2005, Volume: 289, Issue:1 Topics: Adenosine; Adenosine Triphosphate; Animals; Brain; Diacetyl; Dopamine; Dopamine Uptake Inhibitors; H	2005
Adenosinergic modulation of ventilation in obese zucker rats. Obesity research, 2005, Volume: 13, Issue:3 Topics: Adenosine; Aminophylline; Animals; Carbon Dioxide; Hypercapnia; Hypoxia; Male; Obesity; Oxygen; Oxyg	2005
Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia. Neuroscience, 2005, Volume: 132, Issue:3 Topics: Adenosine A1 Receptor Antagonists; Animals; Dependovirus; Electric Stimulation; Excitatory Postsynap	2005
Modulation of visual inputs to accessory optic system by theophylline during hypoxia. Experimental brain research, 2006, Volume: 172, Issue:3 Topics: Action Potentials; Adenosine; Animals; Brain Stem; Excitatory Postsynaptic Potentials; Hypoxia; Neur	2006
The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat. The Journal of physiology, 2006, Aug-15, Volume: 575, Issue:Pt 1 Topics: Adenosine; Animals; Blood Pressure; Cardiovascular System; Enzyme Inhibitors; Guanidines; Heart Rate	2006
The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius. American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:2 Topics: Adenosine; Animals; Atropine; Blood Glucose; Brain Chemistry; Carbohydrate Metabolism; Cardiac Outpu	2007
Beyond the "ABC approach". The European respiratory journal, 2007, Volume: 30, Issue:4 Topics: Acute Disease; Bacterial Infections; Biomarkers; C-Reactive Protein; Humans; Hypoxia; Inflammation;	2007
Nucleotide metabolism in spleen and peripheral blood lymphocytes during theophylline treatment. Research communications in chemical pathology and pharmacology, 1984, Volume: 45, Issue:1 Topics: Adenosine Triphosphate; Animals; Cyclic AMP; Hypoxia; Luciferases; Luminescent Measurements; Lymphoc	1984
Chronic airflow obstruction: pathophysiology and management. Comprehensive therapy, 1980, Volume: 6, Issue:5 Topics: Adrenal Cortex Hormones; Adrenergic beta-Agonists; Airway Obstruction; Atropine; Blood Gas Analysis;	1980
Alkaline secretion by amphibian duodenum. III. Effect of DBcAMP, theophylline, and prostaglandins. The American journal of physiology, 1981, Volume: 241, Issue:6 Topics: Animals; Bicarbonates; Bucladesine; Chlorides; Cyclic AMP; Drug Interactions; Duodenum; Hypoxia; Pro	1981
Prolonged inhibition of respiration following acute hypoxia in glomectomized cats. Respiration physiology, 1984, Volume: 57, Issue:3 Topics: Acute Disease; Adenosine; Animals; Carotid Body; Cats; Denervation; Extracellular Space; Hydrogen-Io	1984
Asthma in New Zealand: a response. The New Zealand medical journal, 1983, Mar-09, Volume: 96, Issue:727 Topics: Adrenal Cortex Hormones; Asthma; Bronchodilator Agents; Humans; Hypoxia; New Zealand; Patient Educat	1983
A case of near-miss SIDS developing an abnormal respiratory reaction to hypoxia. Acta paediatrica Scandinavica, 1983, Volume: 72, Issue:5 Topics: Apnea; Humans; Hypoxia; Infant, Newborn; Infant, Newborn, Diseases; Male; Monitoring, Physiologic; P	1983
[Effect of xanthinol nicotinate on brain metabolism in rats]. Arzneimittel-Forschung, 1983, Volume: 33, Issue:5 Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Blood Pressure; Brain Chemistry; Glucose; Hypo	1983
Influence of hypercapnia and/or hypoxemia and metabolic acidosis on theophylline kinetics in the conscious rabbit. The American review of respiratory disease, 1984, Volume: 129, Issue:5 Topics: Acidosis, Respiratory; Animals; Hypercapnia; Hypoxia; Kinetics; Male; Metabolic Clearance Rate; Rabb	1984
Increased hypoxic ventilatory drive due to administration of aminophylline in normal men. Chest, 1980, Volume: 78, Issue:2 Topics: Administration, Oral; Adult; Aminophylline; Carbon Dioxide; Humans; Hypercapnia; Hypoxia; Infusions,	1980
The effect of 2% CO2, 100% O2, theophylline and 15% O2 on "inspiratory drive" and "effective" timing in preterm infants. Early human development, 1981, Volume: 5, Issue:1 Topics: Carbon Dioxide; Female; Humans; Hypoxia; Infant, Newborn; Infant, Premature; Male; Oxygen; Pulmonary	1981
Substrate dependence of myocardial response to hypoxia in the presence of theophylline. The American journal of physiology, 1983, Volume: 245, Issue:2 Topics: Animals; Female; Glycogen; Heart; Heart Ventricles; Hypoxia; In Vitro Techniques; Kinetics; Myocardi	1983
Control of coronary flow by local factors during hypoxia with and without a fall in O2 consumption. Blood vessels, 1982, Volume: 19, Issue:3 Topics: Adenosine; Animals; Blood Flow Velocity; Coronary Circulation; Dose-Response Relationship, Drug; Fem	1982
Role of mitochondrial oxidative phosphorylation in regulation of coronary blood flow. The American journal of physiology, 1982, Volume: 243, Issue:2 Topics: Adenosine; Amobarbital; Animals; Calcium; Coronary Circulation; Hypoxanthines; Hypoxia; Inosine; Lac	1982
Aminophylline does not inhibit canine hypoxic pulmonary vasoconstriction. The American review of respiratory disease, 1982, Volume: 126, Issue:6 Topics: Aminophylline; Animals; Cardiac Output; Dogs; Half-Life; Hypoxia; Oxygen; Pulmonary Circulation; Pul	1982
[The effect of AR-L 115 BS on the function and oxygen consumption of isolated guinea pig atria as compared to g-strophanthin and theophylline]. Arzneimittel-Forschung, 1981, Volume: 31, Issue:1a Topics: Animals; Cardiotonic Agents; Guinea Pigs; Heart; Hypoxia; Imidazoles; In Vitro Techniques; Myocardia	1981
Norepinephrine-stimulated lipolysis in acute and chronic hypoxemia. The American journal of physiology, 1981, Volume: 241, Issue:1 Topics: Acute Disease; Animals; Chronic Disease; Dogs; Fatty Acids, Nonesterified; Glycerol; Hypoxia; Lipid	1981
Development of a cardiac antiarrhythmic screening test utilizing theophylline in the rat. Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 243, Issue:1 Topics: Acetates; Aminophylline; Animals; Anti-Arrhythmia Agents; Chloroform; Drug Evaluation, Preclinical;	1980
Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia. The American journal of physiology, 1995, Volume: 269, Issue:3 Pt 2 Topics: Animals; Arginine; Arteries; Benzopyrans; Cerebrovascular Circulation; Cromakalim; Glyburide; Hyperc	1995
Theophylline and hypoxic ventilatory response in the rat isolated brainstem-spinal cord. Respiration physiology, 1995, Volume: 100, Issue:1 Topics: Animals; Animals, Newborn; Brain; Hypoxia; In Vitro Techniques; Phrenic Nerve; Purinergic P1 Recepto	1995
Adenosine modulates hypoxia-induced atrial natriuretic peptide release in fetal sheep. The American journal of physiology, 1995, Volume: 269, Issue:1 Pt 2 Topics: Adenosine; Animals; Atrial Natriuretic Factor; Blood Pressure; Fetal Blood; Gases; Heart Rate; Hemog	1995
Role for ATP-sensitive K+ channel in the development of A-V block during hypoxia. Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:1 Topics: Action Potentials; Adenosine Triphosphate; Animals; Atrioventricular Node; Deoxyglucose; Female; Glu	1995
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis. European journal of pharmacology, 1994, Aug-03, Volume: 270, Issue:4 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals;	1994
Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia. Experimental physiology, 1994, Volume: 79, Issue:5 Topics: 2-Chloroadenosine; Adenosine; Adenosine Deaminase; Animals; Blood Gas Analysis; Blood Pressure; Hear	1994
Contribution of prostaglandins in hypoxia-induced vasodilation in isolated rabbit hearts. Relation to adenosine and KATP channels. Pflugers Archiv : European journal of physiology, 1994, Volume: 428, Issue:5-6 Topics: Adenosine; Adenosine Triphosphate; Animals; Cyclic AMP; Diclofenac; Epoprostenol; Heart; Hypoxia; My	1994
Protective effect of hypoxia on mechanical and metabolic changes induced by hydrogen peroxide in rat hearts. The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 2 Topics: Animals; Glyburide; Heart; Hydrogen Peroxide; Hypoxia; In Vitro Techniques; Male; Myocardium; Purine	1995
Pentoxifylline prevents a decrease in arterial oxygen tension in oleic acid-induced lung injury. Critical care medicine, 1995, Volume: 23, Issue:2 Topics: Airway Resistance; Animals; Blood Pressure; Capillary Permeability; Carbon Dioxide; Guinea Pigs; Hyd	1995
Interdependence of respiratory and cardiovascular changes induced by systemic hypoxia in the rat: the roles of adenosine. The Journal of physiology, 1994, Nov-01, Volume: 480 ( Pt 3) Topics: Adenosine; Animals; Cardiovascular System; Carotid Arteries; Cerebrovascular Circulation; Hypoxia; P	1994
Endogenous adenosine deaminase does not modulate synaptic transmission in rat hippocampal slices under normoxic or hypoxic conditions. Neuroscience, 1994, Volume: 63, Issue:2 Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Electrophysiology; Hippocampu	1994
Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. British journal of pharmacology, 1994, Volume: 111, Issue:3 Topics: Adenosine; Adenosine Triphosphate; Animals; Arginine; Capsaicin; Coronary Vessels; Endothelium, Vasc	1994
Changes in adenosine receptors in the neonatal rat brain following hypoxic ischemia. Brain research. Molecular brain research, 1994, Volume: 23, Issue:4 Topics: Animals; Animals, Newborn; Brain; Cerebral Cortex; Down-Regulation; Female; Guanosine Triphosphate;	1994
Role of adenosine in the hypoxic ventilatory response of the newborn piglet. Pediatric pulmonology, 1994, Volume: 17, Issue:1 Topics: Adenosine; Animals; Animals, Newborn; Caffeine; Cerebrospinal Fluid; Citrates; Dipyridamole; Drug Co	1994
A link between adenosine, ATP-sensitive K+ channels, potassium and muscle vasodilatation in the rat in systemic hypoxia. The Journal of physiology, 1993, Volume: 472 Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Glyburide; Hypoxia; Muscles; Potassiu	1993
Preconditioning in isolated superfused rabbit papillary muscles. The American journal of physiology, 1994, Volume: 266, Issue:4 Pt 2 Topics: Animals; Cardiac Pacing, Artificial; Homeostasis; Hypoxia; In Vitro Techniques; Male; Myocardial Stu	1994
Effects of 5'-N-ethylcarboxamideadenosine (NECA) on erythropoietin production. Kidney international, 1993, Volume: 44, Issue:4 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Carci	1993
Mucosal permeability in the immature rat intestine: effects of ischemia-reperfusion, cold stress, hypoxia, and drugs. Journal of pediatric surgery, 1993, Volume: 28, Issue:10 Topics: Animals; Animals, Newborn; Cell Membrane Permeability; Cold Temperature; Dose-Response Relationship,	1993
Adenosine antagonists prevent hypoxia-induced depression of excitatory but not inhibitory synaptic currents. Neuroscience letters, 1993, Sep-03, Volume: 159, Issue:1-2 Topics: Adenosine; Animals; Electrophysiology; Hypoxia; In Vitro Techniques; Models, Neurological; Purinergi	1993
Adenosine mediates hypoxic release of arginine vasopressin in fetal sheep. The American journal of physiology, 1994, Volume: 266, Issue:1 Pt 2 Topics: Adenosine; Animals; Arginine Vasopressin; Blood Pressure; Fetus; Gases; Heart Rate; Hydrogen-Ion Con	1994
Adenosine, a "retaliatory" metabolite, promotes anoxia tolerance in turtle brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1993, Volume: 13, Issue:4 Topics: Adenosine; Animals; Brain; Cerebellum; Hypoxia; In Vitro Techniques; Purinergic Antagonists; Theophy	1993
Evidence for decrease in myofilament responsiveness to Ca2+ during hypoxia in spontaneously active vascular smooth muscle in rats. Experimental physiology, 1993, Volume: 78, Issue:3 Topics: Actin Cytoskeleton; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Calcium; Chlorides; Cy	1993
The role of adenosine in hypoxic pulmonary vasoconstriction in the anaesthetized rat. Experimental physiology, 1993, Volume: 78, Issue:4 Topics: Adenosine; Animals; Blood Pressure; Hypoxia; Lung; Pulmonary Artery; Pulmonary Veins; Rats; Rats, Wi	1993
Hypoxia preconditions rabbit myocardium via adenosine and catecholamine release. Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:8 Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Catecholamines; Heart; Hemodynamics; Hypoxia; In V	1995
A study on rats of the effects of chronic hypoxia from birth on respiratory and cardiovascular responses evoked by acute hypoxia. The Journal of physiology, 1995, Sep-01, Volume: 487 ( Pt 2) Topics: Adenosine; Animals; Animals, Newborn; Blood Gas Analysis; Cardiovascular System; Hypoxia; Potassium;	1995
Adenosine mediates metabolic and cardiovascular responses to hypoxia in fetal sheep. The Journal of physiology, 1995, Nov-01, Volume: 488 ( Pt 3) Topics: Acidosis; Adenosine; Animals; Blood Pressure; Female; Fetus; Glycolysis; Heart Rate; Hypoxia; Pregna	1995
Effect of theophylline on metabolic and ventilatory response to hypoxemia during quiet sleep in piglets. Pediatric research, 1995, Volume: 38, Issue:6 Topics: Animals; Drug Evaluation, Preclinical; Hypoxia; Respiratory Mechanics; Sleep; Swine; Theophylline	1995
Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation. Acta physiologica Scandinavica, 1995, Volume: 155, Issue:3 Topics: Adenosine; Adult; Blood Pressure; Coronary Circulation; Coronary Vessels; Female; Heart Rate; Humans	1995
Action of adenosine receptor antagonists on hypoxia-induced effects in the rat hippocampus in vitro. British journal of pharmacology, 1995, Volume: 116, Issue:3 Topics: Adenosine; Animals; Corpus Striatum; Dizocilpine Maleate; Hypoxia; Male; Membrane Potentials; Microe	1995
Effect of theophylline on ventilatory roll-off during hypoxia in goats. Respiration physiology, 1996, Volume: 103, Issue:2 Topics: Animals; Goats; Hypoxia; Pulmonary Ventilation; Theophylline	1996
Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. The Journal of physiology, 1996, Sep-01, Volume: 495 ( Pt 2) Topics: 5'-Nucleotidase; Acute Disease; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; E	1996
Effect of nifedipine on the elimination of theophylline in the rabbit subjected to hypoxia or to an inflammatory reaction. The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:9 Topics: Animals; Area Under Curve; Bronchodilator Agents; Calcium Channel Blockers; Cytochrome P-450 Enzyme	1996
Integration of vascular, contractile and metabolic responses to hypoxia: effects of maturation and adenosine. The American journal of physiology, 1996, Volume: 270, Issue:4 Pt 2 Topics: Adenosine; Aging; Animals; Coronary Circulation; Coronary Vessels; Energy Metabolism; Heart; Hemodyn	1996
Role of nitric oxide, cyclic nucleotides, and the activation of ATP-sensitive K+ channels in the contribution of adenosine to hypoxia-induced pial artery dilation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1997, Volume: 17, Issue:1 Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Arteries; Blood Pressure; Cyclic AM	1997
Postnatal development of the pattern of respiratory and cardiovascular response to systemic hypoxia in the piglet: the roles of adenosine. The Journal of physiology, 1996, Apr-15, Volume: 492 ( Pt 2) Topics: 2-Chloroadenosine; Adenosine; Aging; Animals; Animals, Newborn; Cardiovascular System; Hypoxia; Resp	1996
A role for adenosine in metabolic depression in the marine invertebrate Sipunculus nudus. The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 2 Topics: Adenosine; Animals; Hypercapnia; Hypoxia; Nematoda; Nerve Tissue; Neurotransmitter Agents; Oxygen Co	1997
P1-purinoceptor-mediated vasodilatation and vasoconstriction in hypoxia. Journal of autonomic pharmacology, 1996, Volume: 16, Issue:6 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Guinea Pigs; Hypoxia; In Vitro Techniques; In	1996
Endogenous adenosine on membrane properties of CA1 neurons in rat hippocampal slices during normoxia and hypoxia. Neuropharmacology, 1997, Volume: 36, Issue:2 Topics: Adenosine; Adenosine Deaminase; Animals; Electric Stimulation; Hippocampus; Hypoxia; In Vitro Techni	1997
The roles of adenosine in regulating the respiratory and cardiovascular systems in chronically hypoxic, adult rats. The Journal of physiology, 1997, Jun-01, Volume: 501 ( Pt 2) Topics: Adenosine; Animals; Blood Gas Analysis; Cerebrovascular Circulation; Hemodynamics; Hindlimb; Hypoxia	1997
Long-lasting treatment with adenosine receptor antagonists: effects on hypoxic tolerance and vascular responsiveness. Acta physiologica Hungarica, 1996, Volume: 84, Issue:3 Topics: Aminophylline; Animals; Atrial Function; Cardiotonic Agents; Dinoprost; Female; Guinea Pigs; Hypoxia	1996
Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats. Kidney international, 1997, Volume: 52, Issue:2 Topics: Adenine; Adenosine; Adenosine Diphosphate; Animals; Antihypertensive Agents; Carbon Monoxide; Dipyri	1997
Effect of theophylline on hypoxic pulmonary vasoconstriction in awake rats. The Tohoku journal of experimental medicine, 1997, Volume: 182, Issue:3 Topics: Animals; Blood Gas Analysis; Body Weight; Hemodynamics; Hemoglobins; Hydrogen-Ion Concentration; Hyp	1997
Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. Stroke, 1998, Volume: 29, Issue:1 Topics: Adenosine; Adenosine Triphosphate; Administration, Topical; Analysis of Variance; Animals; Arteriole	1998
Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo. British journal of cancer, 1998, Volume: 77, Issue:2 Topics: Adenocarcinoma; Animals; Bromodeoxyuridine; Cell Cycle; Cell Division; DNA, Neoplasm; Flow Cytometry	1998
Inhibitory effects of hypoxia and adenosine on N-methyl-D-aspartate-induced pial arteriolar dilation in piglets. Brain research, 1998, Jan-12, Volume: 780, Issue:2 Topics: Adenosine; Animals; Animals, Newborn; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulatio	1998
Low concentrations of adenosine receptor blocker decrease protection by hypoxic preconditioning in ischemic rat hearts. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:3 Topics: Adenosine; Adenosine Triphosphate; Animals; Creatine Kinase; Hypoxia; In Vitro Techniques; Ischemic	1998
Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. The Journal of physiology, 1998, Jun-01, Volume: 509 ( Pt 2) Topics: Adenosine; Animals; Blood Flow Velocity; Blood-Brain Barrier; Erythrocytes; Hypoxia; Laser-Doppler F	1998
Neuromodulators and hypoxic hypothermia in the rat. Respiration physiology, 1998, Volume: 112, Issue:3 Topics: Adenosine; Animals; Body Temperature; Carbon Monoxide; Hypothermia; Hypoxia; Male; Naloxone; Narcoti	1998
The effect of theophylline on apnoea and hypoxaemic episodes in the premature neonate during the 1st 3 days after birth. Annals of tropical paediatrics, 1998, Volume: 18, Issue:3 Topics: Apnea; Blood Pressure; Bradycardia; Bronchodilator Agents; Caffeine; Female; Gestational Age; Humans	1998
Adenosine inhibits L-type Ca2+ current and catecholamine release in the rabbit carotid body chemoreceptor cells. The European journal of neuroscience, 1999, Volume: 11, Issue:2 Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; Calcium Channel	1999
Evidence of hypoxic areas within the arterial wall in vivo. Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:4 Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Fluorescent Antibody Technique, Direct; Hypoxia; Male; N	1999
A bioluminescence method for the mapping of local ATP concentrations within the arterial wall, with potential to assess the in vivo situation. Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:4 Topics: Adenosine Triphosphate; Animals; Aorta; Arteriosclerosis; Culture Media; Dose-Response Relationship,	1999
Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1999, Volume: 50, Issue:2 Topics: Animals; Benzimidazoles; Blood Vessels; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Division; End	1999
Effect of hypoxia alone or combined with inflammation and 3-methylcholanthrene on hepatic cytochrome P450 in conscious rabbits. British journal of pharmacology, 1999, Volume: 128, Issue:2 Topics: Animals; Apoproteins; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cyto	1999
A retinal-derived relaxing factor mediates the hypoxic vasodilation of retinal arteries. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:11 Topics: Animals; Cattle; Cyclooxygenase Inhibitors; Dinoprost; Electromyography; Eye Proteins; Hydrogen-Ion	2000
Purinergic contribution to circulatory, metabolic, and adrenergic responses to acute hypoxemia in fetal sheep. American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:3 Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Epinephrine; Female; Femoral Artery; Fetal B	2001
Evidence that the renin decrease during hypoxia is adenosine mediated in conscious dogs. Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 90, Issue:5 Topics: Acute Disease; Adenosine; Aldosterone; Angiotensin I; Angiotensin II; Animals; Blood Pressure; Carbo	2001
Effects of phosphodiesterase inhibitors on hypoxic pulmonary vasoconstriction. Influence of K(+) channels and nitric oxide. European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2 Topics: 4-Aminopyridine; Animals; Apamin; Charybdotoxin; Dose-Response Relationship, Drug; Enzyme Inhibitors	2001
Hypoxic ventilatory depression in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. Respirology (Carlton, Vic.), 2001, Volume: 6, Issue:2 Topics: Adenosine; Adult; Humans; Hypoventilation; Hypoxia; Male; MELAS Syndrome; Theophylline; Vital Capaci	2001
Complementary effects of adenosine and angiotensin II in hypoxemia-induced renal dysfunction in the rabbit. Life sciences, 2002, Jul-05, Volume: 71, Issue:7 Topics: Adenosine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Gas Analysis; Hy	2002
[Changes in acid-base equilibrium of the arterial blood in hypoxemic-eucapnic subjects subjected to oxygen therapy with and without an antiphosphodiesterase drug]. Minerva medica, 1976, Sep-22, Volume: 67, Issue:44 Topics: Acid-Base Equilibrium; Arteries; Blood; Carbon Dioxide; Chlorides; Chronic Disease; Electrolytes; Hu	1976
[The effect of hypoxia on the branchial vascular system of the perfused trout head]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1977, Volume: 171, Issue:4 Topics: Adenosine; Animals; Gills; Hypoxia; Perfusion; Regional Blood Flow; Salmonidae; Theophylline; Trout;	1977
Uptake and metabolism of cyclic AMP in rabbit choroid plexus in vitro. Neuropharmacology, 1977, Volume: 16, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Monophosphate; Animals; Choroid Plexus; Cyclic AMP; C	1977
Regulation of triglyceride metabolism in the isotopically prelabeled perfused heart. Federation proceedings, 1977, Volume: 36, Issue:7 Topics: Animals; Blood Pressure; Bucladesine; Epinephrine; Fatty Acids; Hypoxia; In Vitro Techniques; Myocar	1977
A study of glycolysis in rat lung. The Indian journal of chest diseases & allied sciences, 1976, Volume: 18, Issue:3 Topics: Animals; Bucladesine; Glycolysis; Hypoxia; Lactates; Lung; Male; Rats; Theophylline	1976
beta-Receptor influence on lung vasoconstrictor responses to hypoxia and humoral agents. Journal of applied physiology: respiratory, environmental and exercise physiology, 1977, Volume: 43, Issue:4 Topics: Acidosis; Animals; Cats; Cyclic AMP; Epinephrine; Histamine; Hypercapnia; Hypoxia; Pulmonary Circula	1977
Ultrastructural changes and cyclic AMP in frog oxyntic cells. The Journal of cell biology, 1978, Volume: 76, Issue:1 Topics: Animals; Anura; Cyclic AMP; Gastric Mucosa; Hypoxia; Metiamide; Rana catesbeiana; Theophylline	1978
An analysis of the drugs acting on cerebral energy metabolism. Japanese journal of pharmacology, 1975, Volume: 25, Issue:3 Topics: Adenine Nucleotides; Amobarbital; Animals; Bemegride; Brain; Dipyridamole; Dogs; Energy Metabolism;	1975
Evidence from bioassay studies indicating a role for adenosine in cardiac ischemic and hypoxic dilation in the dog. Circulation research, 1979, Volume: 45, Issue:4 Topics: Adenosine; Adenosine Deaminase; Adenosine Monophosphate; Animals; Biological Assay; Coronary Circula	1979
The xanthine treatment of apnea of prematurity. Pediatrics, 1975, Volume: 55, Issue:5 Topics: Aminophylline; Apnea; Bradycardia; Caffeine; Humans; Hypoxia; Infant, Newborn; Infant, Premature, Di	1975
Beta adrenergic receptor dysfunction in hypoxic inhibition of insulin release. Endocrinology, 1976, Volume: 98, Issue:2 Topics: Animals; Blood Glucose; Carbon Dioxide; Dogs; Epinephrine; Glucose; Hypoxia; Insulin; Insulin Secret	1976
Neuropeptide Y and catecholamine release in the piglet during hypoxia: enhancement by theophylline. Journal of developmental physiology, 1992, Volume: 18, Issue:4 Topics: Animals; Animals, Newborn; Carbon Dioxide; Epinephrine; Hypoxia; Neuropeptide Y; Norepinephrine; Oxy	1992
Plasma adenosine and cardiovascular responses to dipyridamole in fetal sheep. Journal of developmental physiology, 1992, Volume: 18, Issue:5 Topics: Adenosine; Animals; Blood Pressure; Dipyridamole; Female; Fetus; Gestational Age; Heart Rate, Fetal;	1992
Canine coronary vasodepressor responses to hypoxia are attenuated but not abolished by 8-phenyltheophylline. The American journal of physiology, 1992, Volume: 262, Issue:4 Pt 2 Topics: Adenosine; Animals; Coronary Circulation; Dogs; Heart; Hemodynamics; Hypoxia; Pressure; Solutions; T	1992
Hypoxia produces cell death in the rat hippocampus in the presence of an A1 adenosine receptor antagonist: an anatomical and behavioral study. Neuroscience, 1992, Volume: 48, Issue:4 Topics: Animals; Avoidance Learning; Cell Death; Cognition; Hippocampus; Hypoxia; Male; Memory; Motor Activi	1992
Increased erythropoietin secretion in human hepatoma cells by N6-cyclohexyladenosine. The American journal of physiology, 1991, Volume: 261, Issue:3 Pt 1 Topics: Adenosine; Anaerobiosis; Bucladesine; Carcinoma, Hepatocellular; Cell Line; Cell Survival; Cyclic AM	1991
Hypoxic vasodilatation in isolated, perfused guinea-pig heart: an analysis of the underlying mechanisms. The Journal of physiology, 1991, Volume: 442 Topics: Adenosine; Animals; Arginine; Coronary Vessels; Deoxyglucose; Glycolysis; Guinea Pigs; Hypoxia; Nitr	1991
The role of adenosine in the respiratory and cardiovascular response to systemic hypoxia in the rat. The Journal of physiology, 1991, Volume: 440 Topics: Adenosine; Animals; Blood Pressure; Female; Heart Rate; Hemodynamics; Hypoxia; Male; Rats; Rats, Inb	1991
Behavioral arousal in newborn infants and its association with termination of apnea. Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 70, Issue:6 Topics: Airway Obstruction; Apnea; Arousal; Humans; Hypercapnia; Hypoxia; Infant, Newborn; Infant, Premature	1991
Endogenous adenosine enhances vagal negative chronotropic effect during hypoxia in the anaesthetised rabbit. Cardiovascular research, 1990, Volume: 24, Issue:7 Topics: Adenosine; Anesthesia; Animals; Depression, Chemical; Female; Heart Rate; Hypoxia; Male; Rabbits; Th	1990
Hypoxia-induced vasodilation of the feline superior mesenteric artery is not adenosine mediated. The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 1 Topics: Adenosine; Animals; Cats; Hypoxia; Isoproterenol; Mesenteric Arteries; Oxygen; Partial Pressure; Rec	1990
Influence of adenosine on cerebral blood flow during hypoxic hypoxia in the newborn piglet. Journal of applied physiology (Bethesda, Md. : 1985), 1990, Volume: 68, Issue:4 Topics: Adenosine; Animals; Animals, Newborn; Arteries; Cerebrovascular Circulation; Chromatography, High Pr	1990
Theophylline disposition in patients with COLD with and without hypoxemia. Chest, 1989, Volume: 95, Issue:5 Topics: Biotransformation; Carbon Dioxide; Female; Humans; Hypoxia; Lung Diseases, Obstructive; Male; Middle	1989
Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts. The American journal of physiology, 1989, Volume: 257, Issue:5 Pt 2 Topics: Adenosine; Anaphylaxis; Animals; Antigens; Atrioventricular Node; Coronary Circulation; Guinea Pigs;	1989
Blood oxygen tension-related change of theophylline clearance in experimental hypoxemia. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 248, Issue:3 Topics: Animals; Hypoxia; Lung Diseases, Obstructive; Male; Metabolic Clearance Rate; Oxygen; Partial Pressu	1989
Effects of theophylline and S 9795 on hyperoxic and hypoxic pulmonary vascular tone in intact dogs. The European respiratory journal, 1989, Volume: 2, Issue:4 Topics: Animals; Bronchodilator Agents; Dogs; Heart Rate; Hypoxia; Injections, Intravenous; Pulmonary Circul	1989
Canine coronary vasodepressor responses to hypoxia are abolished by 8-phenyltheophylline. The American journal of physiology, 1989, Volume: 257, Issue:4 Pt 2 Topics: Adenosine; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Dogs; Female; Heart; Hea	1989
Treatment of pulmonary hypertension. Herz, 1986, Volume: 11, Issue:3 Topics: Adrenergic beta-Agonists; Antihypertensive Agents; Combined Modality Therapy; Humans; Hypertension,	1986
Limitation of theophylline elimination by reduced oxygen availability in mouse hepatocytes and rat isolated livers. Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:8 Topics: Aerobiosis; Anaerobiosis; Animals; Chromatography, High Pressure Liquid; Hypoxia; In Vitro Technique	1985
Pharmacological characterization of the receptor involved in chemoexcitation induced by adenosine. British journal of pharmacology, 1986, Volume: 88, Issue:3 Topics: Adenosine; Animals; Carotid Body; Cats; Hypoxia; Receptors, Cell Surface; Receptors, Purinergic; Sti	1986
Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and hypoxia. The American journal of physiology, 1987, Volume: 253, Issue:1 Pt 2 Topics: Adenosine; Animals; Brain; Cerebrovascular Circulation; Cyclic AMP; Hypoxia; Osmolar Concentration;	1987
Effect of hypoxia on nerve-stimulation-induced release of noradrenaline from the rabbit heart. Acta physiologica Scandinavica, 1988, Volume: 133, Issue:1 Topics: Adenosine; Animals; Electric Stimulation; Epoprostenol; Female; Heart; Hypoxia; Indomethacin; Male;	1988
Theophylline effect on the cerebral blood flow response to hypoxemia. Chest, 1988, Volume: 94, Issue:2 Topics: Adult; Cerebrovascular Circulation; Hemodynamics; Humans; Hypoxia; Male; Theophylline	1988
A1 and A2 adenosine receptor regulation of erythropoietin production. Life sciences, 1988, Volume: 43, Issue:3 Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Albuterol; Animals; Erythrocytes; Erythropoietin; Fema	1988
Theophylline prevents the hypoxemia-induced renal hemodynamic changes in rabbits. Kidney international, 1988, Volume: 33, Issue:6 Topics: Adenosine; Animals; Animals, Newborn; Glomerular Filtration Rate; Hypoxia; Kidney; Rabbits; Renal Ci	1988
Moderate hypoxia: reactivity of pial arteries and local effect of theophylline. Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 63, Issue:6 Topics: Adenosine; Animals; Cats; Cerebral Arteries; Female; Hypoxia; Infusions, Intravenous; Male; Theophyl	1987
Does aminophylline improve nocturnal hypoxia in patients with chronic airflow obstruction? European journal of respiratory diseases, 1987, Volume: 71, Issue:5 Topics: Aged; Aminophylline; Humans; Hypoxia; Infusions, Intravenous; Lung Diseases, Obstructive; Male; Midd	1987
The effect of theophylline on regional cerebral blood flow responses to hypoxia in newborn piglets. Pediatric research, 1987, Volume: 21, Issue:6 Topics: Animals; Animals, Newborn; Blood Pressure; Brain; Cerebrovascular Circulation; Heart Rate; Hypoxia;	1987
Theophylline disposition during acute and chronic hypoxia in the conscious dog. Research communications in chemical pathology and pharmacology, 1987, Volume: 57, Issue:3 Topics: Acute Disease; Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Dogs; Female; Hypoxia; Male	1987
Role of hypoxia and acetylcholine in the regulation of cerebral blood flow. Advances in experimental medicine and biology, 1987, Volume: 215 Topics: Acetylcholine; Adenosine Deaminase; Animals; Cats; Cerebral Arteries; Cerebral Cortex; Cerebrovascul	1987
Effect of theophylline treatment on the functional hyperaemic and hypoxic responses of cerebrocortical microcirculation. Acta physiologica Hungarica, 1986, Volume: 68, Issue:2 Topics: Adenosine; Animals; Cats; Cerebral Cortex; Cerebrovascular Circulation; Extracellular Space; Hyperem	1986
Regulation of cerebral blood flow (CBF) during hypoxia and epileptic seizures. Advances in experimental medicine and biology, 1985, Volume: 191 Topics: 2-Chloroadenosine; Adenosine; Amobarbital; Animals; Cats; Cerebrovascular Circulation; Cyanides; Epi	1985
Correlations between electrical and pharmacological observations during anoxia in the rabbit, in normal and assisted respiration. Electroencephalography and clinical neurophysiology, 1971, Volume: 30, Issue:3 Topics: Amphetamine; Brain; Caffeine; Electroencephalography; Ethylamines; Hypoxia; Meclofenoxate; Methylphe	1971
Effect of acetaldehyde on the isolated, non-working guinea-pig heart: independence of the coronary flow increase from changes in heart rate and oxygen consumption. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:3 Topics: Acetaldehyde; Acetates; Animals; Atropine; Coronary Circulation; Epinephrine; Ethanol; Guinea Pigs;	1974
[Influence of metabolism-inhibiting as well as metabolism-accelerating and ionotropic drugs on myocardial survival time in the rat under anoxia conditions]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1974, Aug-15, Volume: 29, Issue:16 Topics: Adrenergic beta-Antagonists; Allopurinol; Animals; Carnitine; Cell Survival; Digitoxin; Female; Hear	1974
Pharmacological effects on coronary reactive hyperemia in conscious dogs. Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1971, Volume: 269, Issue:1 Topics: Animals; Coronary Disease; Coronary Vessels; Coumarins; Dipyridamole; Dogs; Drug Synergism; Glycolat	1971
Induction of delta-aminolaevulinate synthetase under environmental-stress conditions. The Biochemical journal, 1973, Volume: 136, Issue:4 Topics: 5-Aminolevulinate Synthetase; Adenosine Triphosphate; Animals; Atmospheric Pressure; Cold Temperatur	1973
Changes in spleen weight, cyclic-AMP content, and serum-corticosterone levels of rats in response to CO2. Canadian journal of physiology and pharmacology, 1974, Volume: 52, Issue:6 Topics: Adrenal Glands; Animals; Carbon Dioxide; Corticosterone; Cyclic AMP; Cyclic GMP; Denervation; Hypoxi	1974
[Effect of Verapamil on the metabolism of myocardium]. Arzneimittel-Forschung, 1970, Volume: 20, Issue:5 Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Asphyxia; Blood Glucos	1970
[Effect of xanthinol micotinate on the ATP concentration of human and animal erythrocytes in vivo and in vitro]. Arzneimittel-Forschung, 1973, Volume: 23, Issue:4 Topics: Adenosine Triphosphate; Animals; Atmospheric Pressure; Cattle; Erythrocyte Aging; Erythrocytes; Fema	1973
The demonstration of energy dependence of the isoproterenol-induced transcellular Ca2+ current in isolated perfused guinea pig hearts--an explanation for mechanical failure of ischemic myocardium. The Journal of surgical research, 1974, Volume: 16, Issue:4 Topics: Action Potentials; Animals; Biological Transport; Caffeine; Calcium; Cell Membrane; Cell Membrane Pe	1974
Theophylline-stimulated aerobic glucose uptake by rat thymocytes exposed to anoxia. Experientia, 1972, Jan-15, Volume: 28, Issue:1 Topics: Animals; Carbon Dioxide; Glucose; Hypoxia; In Vitro Techniques; Lactates; Male; Oxygen; Rats; Theoph	1972
[Use of radionuclides in the study of the regional distribution of pulmonary perfusion and ventilation]. Recenti progressi in medicina, 1971, Volume: 50, Issue:2 Topics: Acetylcholine; Age Factors; Ethylenediamines; Humans; Hypertension; Hypoxia; Lung; Lung Compliance;	1971
Changes in the pulmonary circulation after bronchial occlusion in anesthetized dogs and cats. Circulation research, 1969, Volume: 25, Issue:6 Topics: Air; Animals; Bicarbonates; Blood Flow Velocity; Blood Pressure; Bretylium Compounds; Cats; Dogs; Hy	1969
[Arterial pO2 modified by Complamin in hyaline membrane disease and aspiration syndromes of premature and term infants]. Monatsschrift fur Kinderheilkunde, 1969, Volume: 117, Issue:3 Topics: Catheterization; Female; Humans; Hyaline Membrane Disease; Hypoxia; Infant, Newborn; Male; Nicotinic	1969
[Regulation of coronary blood flow in acute oxygen deficiency]. Pflugers Archiv : European journal of physiology, 1970, Volume: 315, Issue:2 Topics: Animals; Blood Flow Velocity; Coronary Vessels; Dogs; Hyperemia; Hypoxia; Nucleosides; Regional Bloo	1970
[Asphyxia neonatorum. II. Treatment with vasodilator and vagolytic agents]. Zeitschrift fur Kinderheilkunde, 1966, Volume: 96, Issue:2 Topics: Acidosis, Respiratory; Asphyxia Neonatorum; Atropine; Blood Circulation; Humans; Hypercapnia; Hypoxi	1966

theophylline and Anoxemia