Page last updated: 2024-10-22

theophylline and Aging

theophylline has been researched along with Aging in 142 studies

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"We tested an aminophylline loading-dose protocol in which asthmatic patients presenting to an emergency department were given a half (3 mg/kg) IV loading dose based on total body weight (TBW) if they had taken a short-acting or sustained-release theophylline preparation within 12 or 24 hours, respectively, prior to arrival: otherwise, a full (6 mg/kg) loading dose was administered."9.06Aminophylline loading in asthmatic patients: a protocol trial. ( Marcus, RH; Parvin, CA; Stine, RJ, 1989)
"Theophylline is commonly used to decrease airway resistance in patients with bronchopulmonary dysplasia (BPD)."7.67Theophylline pharmacokinetics in patients with bronchopulmonary dysplasia. ( Edwards, R; Nahata, MC; Serafini, D, 1989)
"The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children."7.67Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. ( Garg, SK; Kumar, L; Lal, R; Shukla, VK; Singh, S, 1989)
"Analyses of 90 admissions to the Cincinnati Children's Hospital Center, Cincinnati, Ohio, were used to assess the effects of the routine availability of serum theophylline determinations (STD) in treating acute in-hospital asthma over three one-year review periods coinciding with the relative availability of STD."7.66Use of serum theophylline determinations during acute asthma therapy in children. ( Fischer, TJ; Hunter, RH; Kearns, GL, 1982)
"The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults."7.66Relationships between plasma theophylline clearance, liver volume and body weight in children and adults. ( Birkett, DJ; Goldin, A; Grygiel, JJ; Ogborne, M; Ward, H, 1983)
" Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants."5.35Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients. ( Igarashi, T; Iwakawa, S, 2009)
"Cimetidine was a nonselective inhibitor of theophylline metabolic pathways in young men, but it exerted a greater inhibitory effect on N-demethylation pathways in the other groups."5.30Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers. ( Cusack, BJ; Loi, CM; Parker, BM; Vestal, RE, 1997)
"Phenytoin was administered as an i."5.27Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men. ( Crowley, JJ; Cusack, BJ; Jue, SG; Koup, JR; Park, BK; Vestal, RE, 1988)
"When theophylline was added to the incubation mixture, both respiration and calcium uptake were depressed in approximately the same proportion in the mitochondria from old rats, although the mitochondrial ATP of young animals was significantly decreased by this substance."5.27Effects of aging on respiration, ATP levels and calcium transport in rat liver mitochondria. Response to theophylline. ( Alemany, J; de la Cruz, MJ; Miquel, J; Roncero, I, 1988)
") of stable isotope-labeled theophylline was administered with the oral dose of theophylline."5.27Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men. ( Cusack, BJ; Dawson, GW; Mercer, GD; Park, BK; Vestal, RE, 1987)
" Altogether, 2772 serum theophylline concentrations were obtained from 131 normal subjects and 306 patients suffering from chronic asthma or chronic obstructive pulmonary disease who participated in the phase I, II, and III clinical trials in Japan."5.08Population pharmacokinetics of theophylline. III. Premarketing study for a once-daily administered preparation. ( Hori, R; Iwai, T; Iwakawa, S; Komada, F; Maekawa, H; Okumura, K; Shimizu, T; Tanigawara, Y, 1995)
"Our data could not identify excessive adenosine in the older group as the cause of diminished maximal exercise heart rate with aging."5.08The effect of adenosine on the reduced heart rate response to exercise in the elderly. ( Andros, EA; Gerber, JG, 1998)
"We tested an aminophylline loading-dose protocol in which asthmatic patients presenting to an emergency department were given a half (3 mg/kg) IV loading dose based on total body weight (TBW) if they had taken a short-acting or sustained-release theophylline preparation within 12 or 24 hours, respectively, prior to arrival: otherwise, a full (6 mg/kg) loading dose was administered."5.06Aminophylline loading in asthmatic patients: a protocol trial. ( Marcus, RH; Parvin, CA; Stine, RJ, 1989)
"High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e."4.91The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015)
"The influence of aging on the metabolism of phenazone (antipyrine), and the relationship between the formation of 3 phenazone metabolites and the metabolic clearance of theophylline in healthy and frail elderly women, were examined."3.68The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women. ( Breimer, DD; Groen, K; Gulati, RS; Horan, MA; Jansen, EJ; Miljkovic, B; Paramsothy, V; Roberts, NA; van Bezooijen, CF, 1993)
"The effect of post maturational aging on the in vivo disposition of theophylline was examined in the Mongolian gerbils (Meriones unguiculatus) aged 30-39 (old), 12-18 (middle-aged) and 3 (young) months following a 20 mg/kg i."3.68The effects of age on the pharmacokinetics and biotransformation of theophylline in vivo and in vitro in the Mongolian gerbil (Meriones unguiculatus). ( Lesko, L; McMahon, TF; Peggins, JO; Weiner, M, 1992)
"Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured."3.67The relationship between theophylline clearance and age in adult life. ( Jackson, SH; Johnston, A; Turner, P; Woollard, R, 1989)
"Theophylline is commonly used to decrease airway resistance in patients with bronchopulmonary dysplasia (BPD)."3.67Theophylline pharmacokinetics in patients with bronchopulmonary dysplasia. ( Edwards, R; Nahata, MC; Serafini, D, 1989)
"On the assumption that plasma unbound drug concentrations are therapeutically active, the value of saliva concentrations in predicting plasma unbound theophylline concentrations was investigated in 25 ambulatory adults (aged 27 to 84 years) receiving theophylline (225-1350 mg aminophylline daily) for asthma or chronic bronchitis."3.67Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined. ( Bateman, M; Knott, C; Reynolds, F, 1984)
"The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children."3.67Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. ( Garg, SK; Kumar, L; Lal, R; Shukla, VK; Singh, S, 1989)
"Analyses of 90 admissions to the Cincinnati Children's Hospital Center, Cincinnati, Ohio, were used to assess the effects of the routine availability of serum theophylline determinations (STD) in treating acute in-hospital asthma over three one-year review periods coinciding with the relative availability of STD."3.66Use of serum theophylline determinations during acute asthma therapy in children. ( Fischer, TJ; Hunter, RH; Kearns, GL, 1982)
"The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults."3.66Relationships between plasma theophylline clearance, liver volume and body weight in children and adults. ( Birkett, DJ; Goldin, A; Grygiel, JJ; Ogborne, M; Ward, H, 1983)
"Theophylline (T) tissue distribution was studied in 11 premature newborns treated with T for prematurity apnea, who had died from severe pathology."3.66Theophylline distribution in the premature neonate. ( Assael, BM; Bonati, M; Latini, R; Marra, G; Parini, R, 1981)
" Urine samples were collected for 24 h after dosing and analysed for caffeine and eleven of its metabolites by high-performance liquid chromatography."2.66Comparison of the urinary metabolite profile of caffeine in young and elderly males. ( Blanchard, J; Jonkman, JH; Sawers, SJ; Tang-Liu, DD, 1985)
" Especially when used in elderly asthmatic patients, dosage adjustment of theophylline is a requisite since the elderly have several risk factors that may increase the plasma theophylline level, such as reduced clearance, various underlying diseases and multiple coadministered drugs."2.42Differential pharmacokinetics of theophylline in elderly patients. ( Kato, M; Kawai, H; Kojima, J; Ohnishi, A; Ushiama, H; Yoneko, M, 2003)
"Children's risks can differ from those in adults for numerous reasons, one being differences in the pharmacokinetic handling of chemicals."2.42Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents. ( Ginsberg, G; Hattis, D; Russ, A; Sonawane, B, 2004)
"This tremor is normally recordable at a stable frequency of 8-10 Hz, though this can be influenced by age, the amplitude can vary substantially."2.39[Most frequent causes for hand tremor in clinical practice]. ( Málly, J, 1995)
"The risk of seizures secondary to the withdrawal of alcohol (ethanol) and benzodiazepines, and methods employed to minimise the risk are discussed."2.39Drug-induced seizures in the elderly. Causative agents and optimal management. ( Chatel, DM; Dahdal, WY; Franson, KL; Grossberg, GT; Hay, DP; Kotegal, S; Mirza, WU; Neppe, V; Szwabo, PA, 1995)
" When models were evaluated with validation data, a single-exponent model overpredicted clearance and dosing rate in premature neonates and adults with a mean prediction error of ≥50%."1.48Age- and Bodyweight-dependent Allometric Exponent Model for Scaling Clearance and Maintenance Dose of Theophylline From Neonates to Adults. ( Mahmood, I; Tegenge, MA, 2018)
"Although both POPPK and physiologically based pharmacokinetic (PBPK) models can account for age and other covariates within a paediatric population, they generally do not account for real-time growth and maturation of the individuals through the time course of drug exposure; this may be significant in prolonged neonatal studies."1.40Changes in individual drug-independent system parameters during virtual paediatric pharmacokinetic trials: introducing time-varying physiology into a paediatric PBPK model. ( Abduljalil, K; Jamei, M; Johnson, TN; Rostami-Hodjegan, A, 2014)
" Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants."1.35Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients. ( Igarashi, T; Iwakawa, S, 2009)
"To create a general physiologically based pharmacokinetic (PBPK) model for drug disposition in infants and children, covering the age range from birth to adulthood, and to evaluate it with theophylline and midazolam as model drugs."1.33Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs. ( Björkman, S, 2005)
" It also was noticed that young dogs have a slower elimination half-life (1 week old, t 1/2 beta = 987 minutes) than do older animals (8 weeks old, t 1/2 beta = 138 minutes)."1.29Effect of age on theophylline pharmacokinetics in dogs. ( Alberola, J; Arboix, M; Pérez, Y; Puigdemont, A, 1993)
"Theophylline is often used in infants, yet few studies have evaluated the serum concentrations achieved with currently recommended dosing guidelines."1.29Pharmacokinetic evaluation of two theophylline dosing methods for infants. ( Fischer, JH; Hatzopoulos, FK; Kraus, DM; Reitz, SJ, 1994)
" A theophylline dosage individualized to obtain a mean theophylline concentration in plasma of 10 +/- 3 micrograms/ml was administered for 1 week to each subject."1.28Safety of fleroxacin coadministered with theophylline to young and elderly volunteers. ( LeBel, M; Parent, M; St-Laurent, M, 1990)
"Dietary protein deficiency led to a significant reduction of total body clearance from approximately 73 to 45 ml/hr/kg in the 2 and 14 month old rats."1.28The effects of age and dietary protein restriction on the pharmacokinetics of theophylline in the rat. ( Jung, D; Nanavaty, M, 1990)
" A one-compartment pharmacokinetic model with first-order elimination was used, with intravenous aminophylline and oral theophylline administration modeled as zero-order infusions."1.28The population pharmacokinetics of theophylline in neonates and young infants. ( Banagale, RC; Faix, RG; Grasela, TH; Moore, ES, 1989)
" The results were opposite to other studies, probably because the dose and dosing intervals were different."1.28Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang. ( Chen, SM; Hou, SJ; Lin, SY; Perng, RI; Young, TK, 1992)
"When glycerol release was calculated as a percentage increase, the effects of these drugs became more marked with age."1.27Age related changes in the antilipolytic effects of nicotinic acid in rat adipose tissue. ( Caparrotta, L; Fassina, G; Gaion, RM; Tessari, F, 1983)
" We conclude that neither time of dosing nor age are important determinants of theophylline elimination kinetics in healthy subjects."1.27Effects of time of dosing and age on intravenous aminophylline pharmacokinetics. ( Bateman, DN; Rodgers, A; Woodhouse, KW, 1987)
" Drugs with flow-limited elimination or mainly oxidative phase I biotransformation should be administered with reduced dosage level while monitoring the serum concentration levels."1.27[The liver and aging. The effect of age on liver function and drug metabolism]. ( Femfert, U; Kuntz, HD; May, B, 1987)
"The pharmacokinetics of two unmatched populations of asthmatic children, one from an asthmatic convalescent center in Denver and the other from an urban outpatient clinic, are compared after single and repeated dosing of a new asthma formulation, oxtriphylline syrup."1.26Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup. ( Bell, T; Danish, M; Katsampes, C; Lecks, H; Ragni, M; Rasmussen, C; Simon, T; Yaffe, S, 1980)
" Rat pups were given either aminophylline, theophylline, or caffeine in a dosage of 40 mg/kg or 80 mg/kg daily from the second postnatal day through 20 days of age."1.26A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain. ( Fuller, GN; Wiggins, RC, 1981)
" Food significantly reduced the absorption rate of theophylline whereas the extent of absorption of theophylline was unaffected by food."1.26Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation. ( Moeller-Petersen, J; Pedersen, S, 1982)
"The biphasic nature of the lipolytic dose-response curve of epinephrine in fat cells from "young" rats (40-45 days) was confirmed."1.25Hormone-stimulated lipolysis in isolated fat cells from "young" and "old" rats. ( Allen, DO; Miller, EA, 1973)

Research

Studies (142)

TimeframeStudies, this research(%)All Research%
pre-199081 (57.04)18.7374
1990's43 (30.28)18.2507
2000's10 (7.04)29.6817
2010's7 (4.93)24.3611
2020's1 (0.70)2.80

Authors

AuthorsStudies
Duman, M1
Vaquié, A1
Nocera, G1
Heller, M1
Stumpe, M1
Siva Sankar, D1
Dengjel, J1
Meijer, D1
Yamaguchi, T1
Matthias, P1
Zeis, T1
Schaeren-Wiemers, N1
Hayoz, A1
Ruff, S1
Jacob, C1
Tegenge, MA1
Mahmood, I1
Kuroda, Y1
Taguchi, K1
Enoki, Y1
Matsumoto, K1
Hori, S1
Kizu, J1
Al-Alawi, M1
Hassan, T1
Chotirmall, SH1
Abduljalil, K1
Jamei, M1
Rostami-Hodjegan, A1
Johnson, TN1
Cutler, RG1
Camandola, S1
Malott, KF1
Edelhauser, MA1
Mattson, MP1
Maharaj, AR1
Edginton, AN1
Sohn, JA1
Kim, HS1
Oh, J1
Cho, JY1
Yu, KS1
Lee, J1
Shin, SH1
Lee, JA1
Choi, CW1
Kim, EK1
Kim, BI1
Park, EA1
Igarashi, T1
Iwakawa, S2
Ohnishi, A1
Kato, M1
Kojima, J1
Ushiama, H1
Yoneko, M1
Kawai, H1
Ginsberg, G1
Hattis, D1
Russ, A1
Sonawane, B1
Sitar, DS1
Nishihara, K1
Björkman, S1
Zimmer, MB1
Goshgarian, HG1
Sachse, KT1
Jackson, EK1
Wisniewski, SR1
Gillespie, DG1
Puccio, AM1
Clark, RS1
Dixon, CE1
Kochanek, PM1
Volpe, JJ1
Bukowskyj, M1
Nakatsu, K1
Munt, PW1
Benzi, G1
Arrigoni, E1
Dagani, F1
Marzatico, F1
Curti, D1
Raimondo, S1
Dossena, M1
Polgatti, M1
Villa, RF1
Stancheva, S2
Ammon, HP1
Amm, U1
Eujen, R1
Hoppe, E1
Trier, G1
Verspohl, EJ1
Caparrotta, L1
Fassina, G1
Gaion, RM1
Tessari, F1
Knott, C1
Bateman, M1
Reynolds, F1
D'Souza, CA1
Friesen, WT1
von Witt, RJ1
Taylor, GR1
Roberts, MS1
Ogilvie, RI1
Besnard, P1
Garel, JM1
Kearns, GL1
Fischer, TJ1
Hunter, RH1
Tserng, KY2
Takieddine, FN2
King, KC2
Fox, RW1
Samaan, S1
Bukantz, SC1
Lockey, RF1
Grygiel, JJ1
Ward, H1
Ogborne, M1
Goldin, A1
Birkett, DJ1
Palacios, R1
Alarcón-Segovia, D1
Llorente, L1
Ruíz-Arguelles, A1
Díaz-Jouanen, E1
Denenberg, VH1
Zeidner, LP1
Thoman, EB1
Kramer, P1
Rowe, JC1
Philipps, AF1
Raye, JR1
Jager-Roman, E1
Doyle, PE1
Thomas, D1
Baird-Lambert, J1
Cvejic, M1
Buchanan, N2
Pedersen, S1
Moeller-Petersen, J1
Fuller, GN1
Wiggins, RC1
Lloyd, HG1
Stone, TW1
Kalhan, SC1
Bonati, M1
Latini, R1
Marra, G1
Assael, BM1
Parini, R1
Bell, T1
Yaffe, S1
Lecks, H1
Danish, M1
Ragni, M1
Simon, T1
Rasmussen, C1
Katsampes, C1
Aldridge, A1
Neims, AH1
Málly, J1
Yderstraede, KB1
Flindt-Egebak, P1
Franson, KL1
Hay, DP1
Neppe, V1
Dahdal, WY1
Mirza, WU1
Grossberg, GT1
Chatel, DM1
Szwabo, PA1
Kotegal, S1
Groen, K2
Breimer, DD2
Brouwer, A1
Schijff, G1
Jansen, EJ2
van Bezooijen, CF2
Suteparuk, S1
Nies, AS1
Andros, E1
Gerber, JG3
Aguila-Mansilla, N1
Kedzierski, W1
Porter, JC1
Marchetti, P1
Scharp, DW1
Finke, EH1
Giannarelli, R1
Swanson, CJ1
Olack, BJ1
Lacy, PE1
Navalesi, R1
Kraus, DM2
Hatzopoulos, FK1
Reitz, SJ2
Fischer, JH2
Coutinho, LL1
Bergen, WG1
Romsos, DR1
Merkel, RA1
Ueno, K1
Tanaka, K1
Shiokawa, M1
Horiuchi, Y1
Kecskes, SA1
Yeh, TF1
McCulloch, KM1
Tung, EC1
Cwik, MJ1
Alberola, J1
Pérez, Y1
Puigdemont, A1
Arboix, M1
Horan, MA1
Roberts, NA1
Gulati, RS1
Miljkovic, B1
Paramsothy, V1
Tanigawara, Y1
Komada, F1
Shimizu, T1
Iwai, T1
Maekawa, H1
Hori, R1
Okumura, K1
Matherne, GP1
Berr, SS1
Headrick, JP1
Elnazir, B1
Marshall, JM1
Kumar, P1
Loi, CM1
Parker, BM1
Cusack, BJ3
Vestal, RE3
Jay, TR1
Heald, KA1
Downing, R1
Yokoyama, H1
Onodera, K1
Yagi, T1
Iinuma, K1
Dumas, TC1
Foster, TC1
Snyder, DL1
Wang, W1
Pelleg, A1
Friedman, E1
Horwitz, J1
Roberts, J1
Andros, EA1
Miller, EA1
Allen, DO1
Popoli, P1
Reggio, R1
Pèzzola, A1
Fuxe, K1
Ferré, S1
Tateishi, T1
Asoh, M1
Yamaguchi, A1
Yoda, T1
Okano, YJ1
Koitabashi, Y1
Kobayashi, S1
Detmar-Hanna, D1
Zahniser, NR1
Erlwanger, KH1
Unmack, MA1
Grøndahl, ML1
Skadhauge, E2
Thorbøll, JE1
Imbeault, P2
Prud'Homme, D1
Tremblay, A2
Després, JP2
Mauriège, P2
Vidal, H1
Vega, N1
Nadeau, A1
Blair, JB1
James, ME1
Foster, JL1
Jusko, WJ1
Gardner, MJ1
Mangione, A1
Schentag, JJ1
Koup, JR2
Vance, JW1
Reĭzin, FN1
Roĭkhel', VM1
Chumakov, MP1
Claycomb, WC1
Sartin, JL2
Pritchett, JF2
Marple, DN2
Harper, WL1
Till, ML1
Gershman, H1
Weis, G1
Barstow, N1
Petkov, V1
Uzunov, P1
Rhomberg, F1
Cusack, B1
Kelly, JG1
Lavan, J1
Noel, J1
O'Malley, K1
Herrschaft, H1
Majerus, TC1
Feroli, ER1
Gross, I1
Rane, A1
Wilson, JT1
Imamura, S1
Kimura, M1
Hiratsuka, E1
Takao, A1
Matsuoka, R1
Lin, SY1
Hou, SJ1
Perng, RI1
Chen, SM1
Young, TK1
Peggins, JO1
McMahon, TF1
Weiner, M1
Lesko, L1
Wang, LC1
Jin, ZL1
Lee, TF1
Gribkoff, VK1
Bauman, LA1
Koga, T1
Takata, Y1
Kobayashi, K1
Fujii, K1
Nagao, T1
Fujishima, M1
Stancheva, SL1
Alova, LG1
Sato-Bigbee, C1
Yu, RK1
Coiro, V1
Volpi, R1
Cavazzini, U1
Bertoni, P1
Corradi, A1
Bianconi, L1
Davoli, C1
Rossi, G1
Chiodera, P1
Labat, C1
Braunstein, G1
Brink, C1
Parent, M1
St-Laurent, M1
LeBel, M1
Sievers, E1
Oldigs, HD1
Dörner, K1
Schaub, J1
Munkres, KD1
Rabinovitch, A1
Sumoski, WL1
Jung, D1
Nanavaty, M1
McEwan, GT1
Schousboe, B1
Nielsen, CG1
de la Cruz, J1
Burón, I1
Roncero, I2
Kumar, L1
Garg, SK1
Singh, S1
Lal, R1
Shukla, VK1
Stine, RJ1
Marcus, RH1
Parvin, CA1
Moore, ES1
Faix, RG1
Banagale, RC1
Grasela, TH1
Bonnacker, I1
Berdel, D1
Süverkrüp, R1
von Berg, A1
Schiffman, SS1
Warwick, ZS1
Nahata, MC1
Serafini, D1
Edwards, R1
Skopińska-Rózewska, E2
Liszewska-Pfejfert, D1
Małkowska-Zwierz, W1
Pawińska, M2
Polakowski, IJ2
Wróblewski, T2
Braaten, B1
Madara, JL1
Donowitz, M1
Finkel, Y1
Eklöf, AC1
Aperia, A1
Karabatas, LM1
Arata, M1
Anaya, L1
Cresto, JC1
Pivetta, OH1
Basabe, JC1
Jackson, SH2
Johnston, A2
Woollard, R1
Turner, P1
Fraschini, F1
Scaglione, F1
Maierna, G1
Cogo, R1
Furcolo, F1
Gattei, R1
Borghi, C1
Palazzini, E1
Burchill, SA1
Thody, AJ1
Yasuhara, M1
Levy, G1
Shin, SG1
Juan, D1
Rammohan, M1
Crowley, JJ1
Jue, SG1
Park, BK2
Alemany, J1
de la Cruz, MJ1
Miquel, J1
Malkowska-Zwierez, W1
Kwarecka, M1
Wlodarska, B1
Pazdur, J1
Rodgers, A1
Woodhouse, KW1
Bateman, DN1
Mercer, GD1
Dawson, GW1
Kuntz, HD1
Femfert, U1
May, B1
Potter, GD1
Burlingame, SM1
Koenig, HG1
Blake, RL1
Wiffen, JK1
Peverel-Cooper, CA1
Au, WY1
Dutt, AK1
DeSoyza, N1
Blanchard, J1
Sawers, SJ1
Jonkman, JH1
Tang-Liu, DD1
Canada, AT1
Calabrese, EJ1
Mackay, AV1
Nakano, J1
Gin, AC1
Ishii, T1
Heinze, E1
Steinke, J1
Livingston, JN1
Cuatrecasas, P1
Lockwood, DH1
Feigelson, M1
Weiss, B1
Stiller, RL1
Horváth, BZ1
Levin, DH1
Scholing, WE1
Clausen, HD1
Williams, MH1
Thomae, H1
Micheli, H1
Carlson, LA1
Hallberg, D1
Jelínková, M1
Stuchlíková, E1
Smrz, M1
Malaisse, WJ1
Malaisse-Lagae, F1
Coleman, DL1
Mies, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Attenuation of Myocardial Dysfunction by N-Acetylcysteine in Infants Undergoing Arterial Switch Procedure[NCT00374088]Phase 221 participants (Actual)Interventional2005-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Max Creatinine

Maximum serum creatinine over first 3 days postoperative. (NCT00374088)
Timeframe: 72 hours

Interventionmg/dL (Mean)
Placebo0.99
N-acetylcysteine0.74

Maximum Decline in Measured Cardiac Output

Serial cardiac output was measured by thermodilution. The outcome of maximum decline in indexed cardiac output from 1 hour postoperative to lowest output within 24 hours postoperative was then calculated and compared between NAC and placebo groups. (NCT00374088)
Timeframe: 24 hours

InterventionL/min/m2 (Mean)
Placebo0.68
N-acetylcysteine0.29

Urine Output

Total urine output over the first 24 hours postoperative (NCT00374088)
Timeframe: 24 hours

InterventionmL (Mean)
Placebo96
N-acetylcysteine176

Reviews

12 reviews available for theophylline and Aging

ArticleYear
Advances in the diagnosis and management of asthma in older adults.
    The American journal of medicine, 2014, Volume: 127, Issue:5

    Topics: Administration, Inhalation; Age Factors; Age of Onset; Aged; Aging; Airway Resistance; Anti-Asthmati

2014
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
    Current topics in medicinal chemistry, 2015, Volume: 15, Issue:21

    Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom

2015
Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aging; Child; Delayed-Action Preparations; Gas

2016
Differential pharmacokinetics of theophylline in elderly patients.
    Drugs & aging, 2003, Volume: 20, Issue:1

    Topics: Aged; Aging; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drug

2003
Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents.
    Journal of toxicology and environmental health. Part A, 2004, Feb-27, Volume: 67, Issue:4

    Topics: Adult; Aging; Caffeine; Environmental Exposure; Half-Life; Humans; Infant, Newborn; Liver; Metabolic

2004
[Bronchodilator: theophylline].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl 12

    Topics: Aging; Asthma; Biomarkers; Bronchodilator Agents; Dosage Forms; Drug Interactions; Drug Monitoring;

2004
Theophylline reassessed.
    Annals of internal medicine, 1984, Volume: 101, Issue:1

    Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents;

1984
Monitoring plasma theophylline concentrations.
    Therapeutic drug monitoring, 1980, Volume: 2, Issue:2

    Topics: Aging; Asthma; Humans; Kinetics; Theophylline

1980
[Most frequent causes for hand tremor in clinical practice].
    Orvosi hetilap, 1995, Oct-08, Volume: 136, Issue:41

    Topics: Aged; Aged, 80 and over; Aging; Female; Hand; Humans; Hypokinesia; Male; Parkinson Disease; Posture;

1995
Drug-induced seizures in the elderly. Causative agents and optimal management.
    Drugs & aging, 1995, Volume: 7, Issue:1

    Topics: Aging; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsants; Antidepressive Agents; Antipsy

1995
Clinical pharmacology of theophylline.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Jul-14, Volume: 56, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aging; Apnea; Arterioles; Biological Availability; Bronchia

1979
Multihormonal regulation of hepatic histidase during postnatal development.
    Enzyme, 1973, Volume: 15, Issue:1

    Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Aging; Ammonia-Lyases; Animals; Buclades

1973

Trials

6 trials available for theophylline and Aging

ArticleYear
Population pharmacokinetics of theophylline. III. Premarketing study for a once-daily administered preparation.
    Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Asthma; Bronchodilator Agen

1995
The effect of adenosine on the reduced heart rate response to exercise in the elderly.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1998, Volume: 53, Issue:2

    Topics: Adenosine; Aged; Aging; Anti-Arrhythmia Agents; Exercise Test; Heart Rate; Humans; Male; Middle Aged

1998
Adipose tissue metabolism in young and middle-aged men after control for total body fatness.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:7

    Topics: Adipose Tissue; Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists;

2000
Aminophylline loading in asthmatic patients: a protocol trial.
    Annals of emergency medicine, 1989, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Aminophylline; Asthma; Body Weight; Clinical Trials as Topic; Emerge

1989
Comparison of the urinary metabolite profile of caffeine in young and elderly males.
    British journal of clinical pharmacology, 1985, Volume: 19, Issue:2

    Topics: Adult; Aged; Aging; Caffeine; Glomerular Filtration Rate; Humans; Male; Random Allocation; Theobromi

1985
[Mental effects of Wallerox therapy in the aged].
    Medizinische Klinik, 1970, Jun-05, Volume: 65, Issue:23

    Topics: Aged; Aging; Bufanolides; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as

1970

Other Studies

124 other studies available for theophylline and Aging

ArticleYear
EEF1A1 deacetylation enables transcriptional activation of remyelination.
    Nature communications, 2020, 07-09, Volume: 11, Issue:1

    Topics: Acetylation; Aging; Animals; Cell Dedifferentiation; Cell Nucleus; Histone Deacetylase 1; Histone De

2020
Age- and Bodyweight-dependent Allometric Exponent Model for Scaling Clearance and Maintenance Dose of Theophylline From Neonates to Adults.
    Therapeutic drug monitoring, 2018, Volume: 40, Issue:5

    Topics: Adult; Aging; Body Weight; Child; Child, Preschool; Drug Dosage Calculations; Female; Humans; Infant

2018
Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice.
    Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:8

    Topics: Aging; Animals; Male; Mice, Inbred ICR; Theophylline; Uric Acid

2019
Changes in individual drug-independent system parameters during virtual paediatric pharmacokinetic trials: introducing time-varying physiology into a paediatric PBPK model.
    The AAPS journal, 2014, Volume: 16, Issue:3

    Topics: Aging; Anticonvulsants; Bronchodilator Agents; Child; Child, Preschool; Clinical Trials as Topic; Hu

2014
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants.
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:6

    Topics: Aging; Apnea; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Female; Genotype; Gestational Age; Hum

2017
Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients.
    Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:2

    Topics: Acute Disease; Aging; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Child; Child, Prescho

2009
Old drugs - old people - new insights.
    The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 2005,Winter, Volume: 12, Issue:1

    Topics: Aging; Humans; Morphine; Pharmaceutical Preparations; Pharmacology, Clinical; Propylthiouracil; Theo

2005
Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:6

    Topics: Adolescent; Aging; Body Composition; Bronchodilator Agents; Cardiac Output; Child; Child, Preschool;

2005
Spontaneous crossed phrenic activity in the neonatal respiratory network.
    Experimental neurology, 2005, Volume: 194, Issue:2

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Brain Stem; Bronchodilator Agents; Efferent Pat

2005
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2008, Volume: 28, Issue:2

    Topics: Adult; Aging; Brain Injuries; Caffeine; Central Nervous System Depressants; Central Nervous System S

2008
Effects of methylxanthines on lipid synthesis in developing neural systems.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Acetyl-CoA Carboxylase; Aging; Aminophylline; Brain; Caffeine; Cell Division; Cell Line; Cholesterol

1981
Age-dependent modification of drug interference on the enzymatic activities of the rat brain.
    Experimental gerontology, 1980, Volume: 15, Issue:6

    Topics: Age Factors; Aging; Animals; Brain; Cytidine Diphosphate Choline; Dihydroergotoxine; Male; Nicergoli

1980
Pharmacological and biochemical study in ontogenetic aspect of 3'-5'-adenosinemonophosphate phosphodiesterases with low and high Km.
    Acta physiologica et pharmacologica Bulgarica, 1981, Volume: 7, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Animals, Newborn; Brain; Ileum; Isoenzymes; Kin

1981
The role of old age in the effects of glucose on insulin secretion, pentosephosphate shunt activity, pyridine nucleotides and glutathione of rat pancreatic islets.
    Life sciences, 1984, Jan-16, Volume: 34, Issue:3

    Topics: Aging; Animals; DNA; Female; Glucose; Glucose Tolerance Test; Glutathione; In Vitro Techniques; Insu

1984
Age related changes in the antilipolytic effects of nicotinic acid in rat adipose tissue.
    British journal of pharmacology, 1983, Volume: 80, Issue:4

    Topics: Adipose Tissue; Aging; Animals; Fatty Acids, Nonesterified; Glycerol; In Vitro Techniques; Lipolysis

1983
Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined.
    British journal of clinical pharmacology, 1984, Volume: 17, Issue:1

    Topics: Adult; Aged; Aging; Asthma; Blood Proteins; Bronchitis; Child; Child, Preschool; Female; Humans; Inf

1984
An audit of therapeutic drug monitoring procedures--use of theophylline assay services.
    Journal of clinical and hospital pharmacy, 1984, Volume: 9, Issue:1

    Topics: Adult; Aging; Australia; Chemistry, Clinical; Drug Therapy, Combination; Drug Utilization; Hospital

1984
[Perifusion study of the secretion of calcitonin in the young rat: effect of isoproterenol and theophylline].
    Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie, 1981, Jan-19, Volume: 292, Issue:3

    Topics: Aging; Animals; Calcitonin; Isoproterenol; Rats; Theophylline; Thyroid Gland

1981
Use of serum theophylline determinations during acute asthma therapy in children.
    Annals of allergy, 1982, Volume: 48, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Aging; Analysis of Variance; Asthma; Child; Child, Hospitalized; C

1982
Developmental aspects of theophylline metabolism in premature infants.
    Clinical pharmacology and therapeutics, 1983, Volume: 33, Issue:4

    Topics: Aging; Gas Chromatography-Mass Spectrometry; Gestational Age; Humans; Infant, Newborn; Infant, Prema

1983
Theophylline kinetics in a geriatric group.
    Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:1

    Topics: Adult; Aged; Aging; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Middle Aged; Regres

1983
Relationships between plasma theophylline clearance, liver volume and body weight in children and adults.
    European journal of clinical pharmacology, 1983, Volume: 24, Issue:4

    Topics: Adult; Aging; Body Weight; Child; Child, Preschool; Female; Humans; Liver; Male; Middle Aged; Organ

1983
Human post-thymic precursor cells in health and disease. I. Characterization of the autologous rosette-forming T cells as post-thymic precursors.
    Immunology, 1981, Volume: 42, Issue:1

    Topics: Adult; Aged; Aging; Feedback; Fetal Blood; Humans; Hydrocortisone; Immune Tolerance; Immunoglobulin

1981
Effects of theophylline on behavioral state development in the newborn rabbit.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 221, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Arousal; Behavior, Animal; Body Weight; Exploratory Behavior; Kine

1982
Increased theophylline metabolism in premature infants after prenatal betamethasone administration.
    Developmental pharmacology and therapeutics, 1982, Volume: 5, Issue:3-4

    Topics: Aging; Betamethasone; Birth Weight; Dealkylation; Female; Gestational Age; Half-Life; Humans; Infant

1982
Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation.
    Allergy, 1982, Volume: 37, Issue:7

    Topics: Adult; Aging; Asthma; Biological Availability; Child; Delayed-Action Preparations; Dose-Response Rel

1982
A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain.
    Brain research, 1981, Jun-01, Volume: 213, Issue:2

    Topics: Aging; Aminophylline; Animals; Body Weight; Brain; Caffeine; Intracellular Membranes; Myelin Sheath;

1981
Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:6

    Topics: Aging; Aminophylline; Animals; Behavior, Animal; Caffeine; Diet; Rats; Rats, Inbred F344; Sex Factor

1981
Postnatal development of theophylline metabolism in preterm infants.
    Seminars in perinatology, 1981, Volume: 5, Issue:4

    Topics: Adult; Aging; Child; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature;

1981
Theophylline distribution in the premature neonate.
    Developmental pharmacology and therapeutics, 1981, Volume: 3, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Apnea; Blood-Brain Barrier; Female; Gestational Age; Guinea Pigs;

1981
Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup.
    Annals of allergy, 1980, Volume: 44, Issue:2

    Topics: Administration, Oral; Aging; Body Height; Body Weight; Child; Choline; Female; Humans; Kinetics; Mal

1980
Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies.
    Biochemical pharmacology, 1980, Jul-01, Volume: 29, Issue:13

    Topics: Aging; Animals; Caffeine; Dealkylation; Dogs; Female; Kinetics; Theobromine; Theophylline; Xanthines

1980
Neonatal rat islets of Langerhans and fetal rat pancreas. Isolation, immunohistochemical, functional, and autoradiographic evaluation.
    Acta diabetologica, 1995, Volume: 32, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cell Separation; Cells, Cultured; Centrifugation,

1995
The influence of dietary restriction on the metabolism of theophylline and antipyrine in the ageing female BN/BiRij rat.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:1

    Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Energy Intake; Female; Rats; Theophyllin

1995
The role of adenosine in promoting cardiac beta-adrenergic subsensitivity in aging humans.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:3

    Topics: Adenosine; Adult; Aged; Aging; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rate;

1995
Localization of a defect in hypothalamic dopaminergic neurons of the aged brain that results in impaired PKA-dependent activation of tyrosine hydroxylase.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Aging; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enzyme Activa

1993
Factors affecting in vitro and in vivo function of isolated porcine islets.
    Transplantation proceedings, 1994, Volume: 26, Issue:6

    Topics: Aging; Animals; Blood Glucose; Cryopreservation; Culture Techniques; Diabetes Mellitus, Experimental

1994
Pharmacokinetic evaluation of two theophylline dosing methods for infants.
    Therapeutic drug monitoring, 1994, Volume: 16, Issue:3

    Topics: Aging; Biological Availability; Evaluation Studies as Topic; Humans; Infant; Retrospective Studies;

1994
Alpha-2 adrenergic receptor activity in porcine adipocytes is androgen and age/cell size dependent.
    Comparative biochemistry and physiology. Comparative physiology, 1993, Volume: 105, Issue:2

    Topics: Adipose Tissue; Aging; Androgens; Animals; Cell Size; Epinephrine; Isoproterenol; Lipolysis; Male; P

1993
Age-dependent changes of renal excretion of theophylline in asthmatic children.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:2

    Topics: Administration, Oral; Aging; Asthma; Bronchitis; Child, Preschool; Chronic Disease; Delayed-Action P

1994
Alterations in theophylline metabolism during the first year of life.
    Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:4

    Topics: Aging; Analysis of Variance; Caffeine; Humans; Infant; Infant, Newborn; Linear Models; Metabolic Cle

1993
Effect of age on theophylline pharmacokinetics in dogs.
    American journal of veterinary research, 1993, Volume: 54, Issue:7

    Topics: Aging; Animals; Body Weight; Chromatography, High Pressure Liquid; Dogs; Half-Life; Male; Metabolic

1993
The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women.
    Clinical pharmacokinetics, 1993, Volume: 25, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Antipyrine; Chromatography, High Pressure Liquid; Female; Fra

1993
Integration of vascular, contractile and metabolic responses to hypoxia: effects of maturation and adenosine.
    The American journal of physiology, 1996, Volume: 270, Issue:4 Pt 2

    Topics: Adenosine; Aging; Animals; Coronary Circulation; Coronary Vessels; Energy Metabolism; Heart; Hemodyn

1996
Postnatal development of the pattern of respiratory and cardiovascular response to systemic hypoxia in the piglet: the roles of adenosine.
    The Journal of physiology, 1996, Apr-15, Volume: 492 ( Pt 2)

    Topics: 2-Chloroadenosine; Adenosine; Aging; Animals; Animals, Newborn; Cardiovascular System; Hypoxia; Resp

1996
Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Biotransformation; Cimetidine; Ciprofloxacin;

1997
Effect of donor age on porcine insulin secretion.
    Transplantation proceedings, 1997, Volume: 29, Issue:4

    Topics: Aging; Animals; Carbachol; Cells, Cultured; Glucose; Insulin; Insulin Secretion; Islets of Langerhan

1997
Therapeutic doses of theophylline exert proconvulsant effects in developing mice.
    Brain & development, 1997, Volume: 19, Issue:6

    Topics: Aging; Animals; Anticonvulsants; Bronchodilator Agents; Dose-Response Relationship, Drug; Electrosho

1997
Late developmental changes in the ability of adenosine A1 receptors to regulate synaptic transmission in the hippocampus.
    Brain research. Developmental brain research, 1998, Jan-14, Volume: 105, Issue:1

    Topics: Aging; Animals; Calcium; Colforsin; Excitatory Postsynaptic Potentials; Extracellular Space; Hippoca

1998
Effect of aging on A1-adenosine receptor-mediated inhibition of norepinephrine release in the rat heart.
    Journal of cardiovascular pharmacology, 1998, Volume: 31, Issue:3

    Topics: Adenosine; Adenosine Deaminase; Aging; Animals; Heart; Male; Myocardium; Norepinephrine; Rats; Rats,

1998
Hormone-stimulated lipolysis in isolated fat cells from "young" and "old" rats.
    Journal of lipid research, 1973, Volume: 14, Issue:3

    Topics: Adipocytes; Adrenocorticotropic Hormone; Aging; Animals; Dose-Response Relationship, Drug; Epinephri

1973
Adenosine A1 and A2A receptor antagonists stimulate motor activity: evidence for an increased effectiveness in aged rats.
    Neuroscience letters, 1998, Jul-31, Volume: 251, Issue:3

    Topics: Aging; Animals; Male; Motor Activity; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, W

1998
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients.
    Pediatric research, 1999, Volume: 45, Issue:1

    Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Th

1999
Lack of an effect of age on beta-adrenoceptor-mediated lipolysis in isolated human adipocytes.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1999, Volume: 54, Issue:2

    Topics: Adipocytes; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; A

1999
Effect of age on vasoactive intestinal polypeptide-induced short-circuit current in porcine jejunum.
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 1999, Volume: 124, Issue:1

    Topics: Aging; Animals; Jejunum; Membrane Potentials; Swine; Theophylline; Vasoactive Intestinal Peptide

1999
Age-related differences in messenger ribonucleic acid expression of key proteins involved in adipose cell differentiation and metabolism.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:2

    Topics: Abdomen; Adipocytes; Adipose Tissue; Adult; Aging; Bucladesine; Canada; Cell Differentiation; Colfor

2001
Adrenergic control of glucose output and adenosine 3':5'-monophosphate levels in hepatocytes from juvenile and adult rats.
    The Journal of biological chemistry, 1979, Aug-25, Volume: 254, Issue:16

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Cyclic AMP; Epinephrine;

1979
Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol.
    Journal of pharmaceutical sciences, 1979, Volume: 68, Issue:11

    Topics: Adult; Aging; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Cannabis; Contraceptives, Oral, Ho

1979
[Effect on drugs changing the intracellular level of adenosine 3',5'-cyclic monophosphate on interferon formation in chick embryo cells of different ages].
    Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 79, Issue:6

    Topics: Aging; Animals; Cells, Cultured; Chick Embryo; Cyclic AMP; Depression, Chemical; Dose-Response Relat

1975
Biochemical aspects of cardiac muscle differentiation. Possible control of deoxyribonucleic acid synthesis and cell differentiation by adrenergic innervation and cyclic adenosine 3':5'-monophosphate.
    The Journal of biological chemistry, 1976, Oct-10, Volume: 251, Issue:19

    Topics: Aging; Animals; Animals, Newborn; Bucladesine; Cell Differentiation; Cyclic AMP; Cyclic GMP; DNA Rep

1976
TSH, theophylline and cyclic AMP: in vitro thyroid activity in aging rats.
    Molecular and cellular endocrinology, 1977, Volume: 9, Issue:2

    Topics: Aging; Animals; Cyclic AMP; In Vitro Techniques; Male; Rats; Theophylline; Thyroid Gland; Thyrotropi

1977
Interaction of aging with in vitro adrenocortical responsiveness to ACTH and cyclic AMP.
    Hormone research, 1979, Volume: 10, Issue:2-3

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aging; Animals; Corticosterone; Cyclic AMP; Male; Rats;

1979
Dibutyryl cyclic AMP suppresses mobility of embryonic chick heart cells in aggregates.
    Journal of cell science, 1979, Volume: 37

    Topics: Aging; Animals; Bucladesine; Cell Aggregation; Cell Movement; Cells, Cultured; Chick Embryo; Depress

1979
Ontogenetic development of 3,5-adenosine monophosphate phosphodiesterase in guinea pig and rat ileum.
    Acta biologica et medica Germanica, 1979, Volume: 38, Issue:7

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Animals, Newborn; Guinea Pigs; Ileum; Kinetics;

1979
[General medical concepts for the dental treatment of aging patients].
    Schweizerische Monatsschrift fur Zahnheilkunde = Revue mensuelle suisse d'odonto-stomatologie, 1977, Volume: 87, Issue:9

    Topics: Aged; Aging; Asthma; Cardiovascular Diseases; Cortisone; Dietary Carbohydrates; Emergencies; Geriatr

1977
The effect of age and smoking on theophylline kinetics [proceedings].
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:4

    Topics: Adult; Aged; Aging; Humans; Kinetics; Smoking; Theophylline

1979
[Can drugs improve the blood supply of the brain? The question of use of so-called vasoactive and metabolic substances in brain arteriosclerosis].
    Schweizerische medizinische Wochenschrift, 1977, Apr-30, Volume: 107, Issue:17

    Topics: Aging; Arteriosclerosis; Brain Diseases; Cerebrovascular Circulation; Humans; Oxygen Consumption; Th

1977
Pharmacokinetics of theophylline therapy.
    American journal of hospital pharmacy, 1977, Volume: 34, Issue:4

    Topics: Aged; Aging; Humans; Kinetics; Theophylline

1977
Nutritional and hormonal influences on lung phospholipid metabolism.
    Federation proceedings, 1977, Volume: 36, Issue:13

    Topics: Adrenal Cortex Hormones; Aging; Animal Nutritional Physiological Phenomena; Animals; Fetus; Insulin;

1977
Clinical pharmacokinetics in infants and children.
    Clinical pharmacokinetics, 1976, Volume: 1, Issue:1

    Topics: Aging; Body Water; Carbamazepine; Child; Child, Preschool; Clindamycin; Dextropropoxyphene; Diazoxid

1976
Effect of caffeine on expression of cardiac myosin heavy chain gene in adult hypothyroid and fetal rats.
    Circulation research, 1992, Volume: 71, Issue:5

    Topics: Aging; Animals; Caffeine; Cyclic AMP; Fetal Heart; Fetus; Gene Expression; Hypothyroidism; Myocardiu

1992
Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang.
    Mechanisms of ageing and development, 1992, Volume: 66, Issue:1

    Topics: Aging; Aminophylline; Animals; Biological Availability; Cimetidine; Cytochrome P-450 Enzyme System;

1992
The effects of age on the pharmacokinetics and biotransformation of theophylline in vivo and in vitro in the Mongolian gerbil (Meriones unguiculatus).
    Mechanisms of ageing and development, 1992, Volume: 66, Issue:2

    Topics: Aging; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Gerbillinae; Half-Life; I

1992
Decrease in cold tolerance of aged rats caused by the enhanced endogenous adenosine activity.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:1

    Topics: Adenosine; Adenosine Deaminase; Adipose Tissue; Aging; Animals; Body Temperature Regulation; Cold Te

1992
Endogenous adenosine contributes to hypoxic synaptic depression in hippocampus from young and aged rats.
    Journal of neurophysiology, 1992, Volume: 68, Issue:2

    Topics: Adenosine; Aging; Animals; Cell Hypoxia; Evoked Potentials; Hippocampus; In Vitro Techniques; Male;

1992
Age-related changes in P2-purinergic receptors on vascular smooth muscle and endothelium.
    Hypertension (Dallas, Tex. : 1979), 1992, Volume: 19, Issue:3

    Topics: Adenosine Triphosphate; Aging; Animals; Aorta; Dose-Response Relationship, Drug; Endothelium, Vascul

1992
Age-related changes of cyclic AMP phosphodiesterase activity in rat brain regions and a new phosphodiesterase inhibitor--nootropic agent adafenoxate.
    General pharmacology, 1991, Volume: 22, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Brain; Cyclic AMP; Kinetics; Meclofenoxate; Ner

1991
Phosphorylation of nuclear proteins in myelinating oligodendrocytes and its control by cyclic AMP.
    Journal of neurochemistry, 1991, Volume: 57, Issue:5

    Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Aging; Animals; Brain; Cyclic AMP; Kinetics; Mo

1991
Restoration of normal growth hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline.
    Journal of gerontology, 1991, Volume: 46, Issue:5

    Topics: Adult; Aged; Aging; Fatty Acids, Nonesterified; Growth Hormone; Growth Hormone-Releasing Hormone; Hu

1991
Isoproterenol activation of prostaglandin production in guinea-pig airway muscle preparations from immature and mature animals.
    Prostaglandins, 1991, Volume: 41, Issue:3

    Topics: Aging; Animals; Bronchi; Dinoprost; Dinoprostone; Enzyme Activation; Guinea Pigs; Histamine; Isoprot

1991
Safety of fleroxacin coadministered with theophylline to young and elderly volunteers.
    Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:6

    Topics: Adult; Aged; Aging; Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Fleroxacin; Hum

1990
Urinary zinc excretion in infancy.
    Journal of trace elements and electrolytes in health and disease, 1990, Volume: 4, Issue:1

    Topics: Aging; Caffeine; Fetus; Humans; Infant Food; Infant, Newborn; Male; Milk, Human; Reproducibility of

1990
Pharmacogenetics of cyclic guanylate, antioxidants, and antioxidant enzymes in Neurospora.
    Free radical biology & medicine, 1990, Volume: 9, Issue:1

    Topics: Aging; Antioxidants; Cell Differentiation; Culture Media; Cyclic GMP; Free Radicals; Gene Expression

1990
Theophylline protects against diabetes in BB rats and potentiates cyclosporine protection.
    Diabetologia, 1990, Volume: 33, Issue:8

    Topics: Aging; Animals; Blood Glucose; Cyclosporins; Diabetes Mellitus, Experimental; Drug Synergism; Female

1990
The effects of age and dietary protein restriction on the pharmacokinetics of theophylline in the rat.
    Pharmacology & toxicology, 1990, Volume: 66, Issue:5

    Topics: Aging; Animals; Body Weight; Kwashiorkor; Liver; Male; Oxidation-Reduction; Protein Deficiency; Rats

1990
Effect of age on the secretory capacity of pig small intestine in vivo and in vitro.
    The American journal of physiology, 1990, Volume: 259, Issue:3 Pt 1

    Topics: Aging; Animals; Chlorides; Cholera Toxin; Dinoprostone; Electric Conductivity; Electrophysiology; Il

1990
Morphological and functional studies during aging at mitochondrial level. Action of drugs.
    The International journal of biochemistry, 1990, Volume: 22, Issue:7

    Topics: Adenosine Triphosphate; Aging; Animals; Calcitonin; Calcium; Female; Male; Mitochondria, Liver; Oxyg

1990
Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children.
    International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:12

    Topics: Adolescent; Aging; Asthma; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Ha

1989
The population pharmacokinetics of theophylline in neonates and young infants.
    Journal of pharmacokinetics and biopharmaceutics, 1989, Volume: 17, Issue:1

    Topics: Aging; Female; Humans; Infant; Infant, Newborn; Male; Models, Biological; Population; Regression Ana

1989
Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:2

    Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; T

1989
Use of flavor-amplified foods to improve nutritional status in elderly patients.
    Annals of the New York Academy of Sciences, 1989, Volume: 561

    Topics: Aged; Aging; Amiloride; Bretylium Tosylate; Caffeine; Flavoring Agents; Humans; Inosine; Inosine Mon

1989
Theophylline pharmacokinetics in patients with bronchopulmonary dysplasia.
    Journal of clinical pharmacy and therapeutics, 1989, Volume: 14, Issue:3

    Topics: Aging; Bronchopulmonary Dysplasia; Humans; Infant; Infant, Newborn; Theophylline

1989
[Subpopulations of t lymphocytes in patients with ischemic heart disease].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1989, Feb-06, Volume: 44, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Aging; Coronary Disease; Humans; Middle Aged; Rosette Formation; T-L

1989
Age-related loss of nongoblet crypt cells parallels decreased secretion in rabbit descending colon.
    The American journal of physiology, 1988, Volume: 255, Issue:1 Pt 1

    Topics: Aging; Algorithms; Amiloride; Animals; Barium; Colon; Cyclic AMP; Electrolytes; Intestinal Absorptio

1988
Mechanisms for colonic sodium transport during ontogeny: loss of an amiloride-sensitive sodium pathway.
    Pediatric research, 1988, Volume: 24, Issue:1

    Topics: Aging; Amiloride; Animals; Animals, Suckling; Biological Transport; Bucladesine; Colon; Cyclic AMP;

1988
First phase of insulin secretion stimulated by glucose plus theophylline and inhibitory effect of somatostatin in genetically diabetic mice (C57BL/KsJ-mdb).
    Diabetologia, 1988, Volume: 31, Issue:6

    Topics: Aging; Animals; Diabetes Mellitus, Experimental; Female; Genetic Carrier Screening; Glucose; Homozyg

1988
The relationship between theophylline clearance and age in adult life.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Asthma; Female; Half-Life; Humans; Male; Metabolic Clearance

1989
Ribavirin influence on theophylline plasma levels in adult and children.
    International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:1

    Topics: Aged; Aging; Child; Delayed-Action Preparations; Drug Interactions; Female; Humans; Immunoenzyme Tec

1988
Melanocyte-stimulating hormone and the regulation of tyrosinase activity in hair follicular melanocytes of the mouse.
    The Journal of endocrinology, 1986, Volume: 111, Issue:2

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Catechol Oxidase; Female; Hair; Hair Color;

1986
Effect of age on neurotoxicity of theophylline.
    Journal of pharmaceutical sciences, 1988, Volume: 77, Issue:7

    Topics: Aging; Animals; Male; Nervous System Diseases; Rats; Rats, Inbred F344; Theophylline

1988
Theophylline pharmacokinetics in normal elderly subjects.
    Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:5

    Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Theo

1988
Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:2

    Topics: Adult; Aged; Aging; Half-Life; Humans; Hydrocortisone; Male; Oxidation-Reduction; Phenytoin; Smoking

1988
Effects of aging on respiration, ATP levels and calcium transport in rat liver mitochondria. Response to theophylline.
    Experimental gerontology, 1988, Volume: 23, Issue:1

    Topics: Adenosine Triphosphate; Aging; Animals; Biological Transport, Active; Calcium; Female; In Vitro Tech

1988
Theophylline-resistant and theophylline-sensitive "early" and "late" E rosette-forming cells in young and aged humans.
    Mechanisms of ageing and development, 1987, Sep-14, Volume: 40, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Antibodies, Monoclonal; Antigens, Surface; Arteriosc

1987
Effects of time of dosing and age on intravenous aminophylline pharmacokinetics.
    British journal of clinical pharmacology, 1987, Volume: 23, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Aminophylline; Circadian Rhythm; Female; Humans; Kinetics; Ma

1987
Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Drug Interactions; Half-Life; Humans; Hydrocortis

1987
[The liver and aging. The effect of age on liver function and drug metabolism].
    Deutsche medizinische Wochenschrift (1946), 1987, May-08, Volume: 112, Issue:19

    Topics: Adult; Aged; Aging; Biotransformation; Female; Galactosemias; Half-Life; Humans; Hymecromone; Indocy

1987
Ion transport by neonatal rabbit distal colon.
    The American journal of physiology, 1986, Volume: 250, Issue:6 Pt 1

    Topics: Aging; Amiloride; Animals; Animals, Newborn; Biological Transport; Chlorides; Colon; Electric Conduc

1986
Rational theophylline use in older asthmatics.
    Geriatrics, 1986, Volume: 41, Issue:8

    Topics: Absorption; Aged; Aging; Anti-Bacterial Agents; Asthma; Drug Interactions; Female; Humans; Kinetics;

1986
The relationship between clearance of theophylline and age within the adult age range.
    European journal of clinical pharmacology, 1985, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Aging; Humans; Immunoenzyme Techniques; Kinetics; Metabolic Clearance Rate; Middl

1985
Theophylline kinetics in chronic obstructive airway disease in the elderly.
    Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:4

    Topics: Aged; Aging; Analysis of Variance; Carbon Dioxide; Half-Life; Humans; Hydrogen-Ion Concentration; In

1985
Ozone-induced inhibition of theophylline elimination in rabbits: effect of age and sex.
    Toxicology and applied pharmacology, 1985, Volume: 81, Issue:1

    Topics: Aging; Animals; Female; Half-Life; Male; Ozone; Rabbits; Sex Factors; Theophylline

1985
The long-term regulation of tyrosine hydroxylase activity in cultured sympathetic ganglia: role of ganglionic noradrenaline content.
    British journal of pharmacology, 1974, Volume: 51, Issue:4

    Topics: Acetylesterase; Aging; Animals; Animals, Newborn; Bucladesine; Carbachol; Choline; Cyclic AMP; Cyclo

1974
Effect of age on norepinephrine-, ACTH-, theophylline- and dibutryl cyclic AMP-induced lipolysis in isolated rat fat cells.
    Journal of gerontology, 1971, Volume: 26, Issue:1

    Topics: Adenine Nucleotides; Adipose Tissue; Adrenocorticotropic Hormone; Aging; Animals; Dexamethasone; Lip

1971
Insulin secretion during development: response of isolated pancreatic islets of fetal, newborn and adult rats to theophylline and arginine.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1972, Volume: 4, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Antigens; Arginine; Female; Fetus; Glucose; Immunoassay; In Vitro

1972
Studies of glucagon resistance in large rat adipocytes: 125I-labeled glucagon binding and lipolytic capacity.
    Journal of lipid research, 1974, Volume: 15, Issue:1

    Topics: Adipose Tissue; Aging; Animals; Bucladesine; Epididymis; Epinephrine; Glucagon; Glycerol; Insulin; I

1974
Dibutyryl cyclic adenosine 3',5-monophosphate and brain lipid metabolism.
    Lipids, 1974, Volume: 9, Issue:8

    Topics: Acetates; Aging; Animals; Brain; Bucladesine; Carbon Radioisotopes; Cerebrosides; Cesium; Cholestero

1974
Adenyl cyclase in the pectoral muscle of normal chickens and chickens with hereditary muscular dystrophy.
    Enzyme, 1972, Volume: 13, Issue:5-6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Chick Embryo; Chickens; Fluo

1972
[The influence of instenon on creative mental functions during aging (author's transl)].
    Wiener klinische Wochenschrift, 1974, Apr-05, Volume: 86, Issue:7

    Topics: Aged; Aging; Benzamides; Benzoates; Cerebrovascular Circulation; Creativity; Drug Combinations; Emot

1974
Special problems in respiratory diseases.
    Geriatrics, 1974, Volume: 29, Issue:6

    Topics: Adrenal Cortex Hormones; Aged; Aging; Anti-Bacterial Agents; Anticoagulants; Asthma; Bronchodilator

1974
Comparison of lipolysis in human subcutaneous and omental adipose tissue with regard to effects of noradrenaline, theophylline, prostaglandin E1 and age.
    Acta chirurgica Scandinavica, 1969, Volume: 135, Issue:8

    Topics: Adipose Tissue; Adolescent; Adult; Aged; Aging; Fatty Acids, Nonesterified; Female; Glycerol; Humans

1969
The effect of theophylline and adrenaline on the lipolytic response of rats of different age.
    Experimental gerontology, 1970, Volume: 5, Issue:3

    Topics: Adipose Tissue; Aging; Animals; Epinephrine; Fatty Acids, Nonesterified; Glycerol; Lipid Metabolism;

1970
Insulin secretion in mice with an hereditary diabetes.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 129, Issue:1

    Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus; Female; Glucose; Insulin; Insulin Secretion; Mice;

1968
[The aging heart and its treatment in general practice].
    Deutsches medizinisches Journal, 1965, Aug-20, Volume: 16, Issue:16

    Topics: Aged; Aging; Coronary Disease; Humans; Plants, Medicinal; Theophylline

1965