theophylline has been researched along with Aging in 142 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We tested an aminophylline loading-dose protocol in which asthmatic patients presenting to an emergency department were given a half (3 mg/kg) IV loading dose based on total body weight (TBW) if they had taken a short-acting or sustained-release theophylline preparation within 12 or 24 hours, respectively, prior to arrival: otherwise, a full (6 mg/kg) loading dose was administered." | 9.06 | Aminophylline loading in asthmatic patients: a protocol trial. ( Marcus, RH; Parvin, CA; Stine, RJ, 1989) |
| "Theophylline is commonly used to decrease airway resistance in patients with bronchopulmonary dysplasia (BPD)." | 7.67 | Theophylline pharmacokinetics in patients with bronchopulmonary dysplasia. ( Edwards, R; Nahata, MC; Serafini, D, 1989) |
| "The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children." | 7.67 | Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. ( Garg, SK; Kumar, L; Lal, R; Shukla, VK; Singh, S, 1989) |
| "Analyses of 90 admissions to the Cincinnati Children's Hospital Center, Cincinnati, Ohio, were used to assess the effects of the routine availability of serum theophylline determinations (STD) in treating acute in-hospital asthma over three one-year review periods coinciding with the relative availability of STD." | 7.66 | Use of serum theophylline determinations during acute asthma therapy in children. ( Fischer, TJ; Hunter, RH; Kearns, GL, 1982) |
| "The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults." | 7.66 | Relationships between plasma theophylline clearance, liver volume and body weight in children and adults. ( Birkett, DJ; Goldin, A; Grygiel, JJ; Ogborne, M; Ward, H, 1983) |
| " Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants." | 5.35 | Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients. ( Igarashi, T; Iwakawa, S, 2009) |
| "Cimetidine was a nonselective inhibitor of theophylline metabolic pathways in young men, but it exerted a greater inhibitory effect on N-demethylation pathways in the other groups." | 5.30 | Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers. ( Cusack, BJ; Loi, CM; Parker, BM; Vestal, RE, 1997) |
| "Phenytoin was administered as an i." | 5.27 | Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men. ( Crowley, JJ; Cusack, BJ; Jue, SG; Koup, JR; Park, BK; Vestal, RE, 1988) |
| "When theophylline was added to the incubation mixture, both respiration and calcium uptake were depressed in approximately the same proportion in the mitochondria from old rats, although the mitochondrial ATP of young animals was significantly decreased by this substance." | 5.27 | Effects of aging on respiration, ATP levels and calcium transport in rat liver mitochondria. Response to theophylline. ( Alemany, J; de la Cruz, MJ; Miquel, J; Roncero, I, 1988) |
| ") of stable isotope-labeled theophylline was administered with the oral dose of theophylline." | 5.27 | Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men. ( Cusack, BJ; Dawson, GW; Mercer, GD; Park, BK; Vestal, RE, 1987) |
| " Altogether, 2772 serum theophylline concentrations were obtained from 131 normal subjects and 306 patients suffering from chronic asthma or chronic obstructive pulmonary disease who participated in the phase I, II, and III clinical trials in Japan." | 5.08 | Population pharmacokinetics of theophylline. III. Premarketing study for a once-daily administered preparation. ( Hori, R; Iwai, T; Iwakawa, S; Komada, F; Maekawa, H; Okumura, K; Shimizu, T; Tanigawara, Y, 1995) |
| "Our data could not identify excessive adenosine in the older group as the cause of diminished maximal exercise heart rate with aging." | 5.08 | The effect of adenosine on the reduced heart rate response to exercise in the elderly. ( Andros, EA; Gerber, JG, 1998) |
| "We tested an aminophylline loading-dose protocol in which asthmatic patients presenting to an emergency department were given a half (3 mg/kg) IV loading dose based on total body weight (TBW) if they had taken a short-acting or sustained-release theophylline preparation within 12 or 24 hours, respectively, prior to arrival: otherwise, a full (6 mg/kg) loading dose was administered." | 5.06 | Aminophylline loading in asthmatic patients: a protocol trial. ( Marcus, RH; Parvin, CA; Stine, RJ, 1989) |
| "High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction transitional metals, antioxidant quenching of superoxide and hydroxyl free radicals, and as an electron donor that increases antioxidant enzyme activity (e." | 4.91 | The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders. ( Camandola, S; Cutler, RG; Edelhauser, MA; Malott, KF; Mattson, MP, 2015) |
| "The influence of aging on the metabolism of phenazone (antipyrine), and the relationship between the formation of 3 phenazone metabolites and the metabolic clearance of theophylline in healthy and frail elderly women, were examined." | 3.68 | The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women. ( Breimer, DD; Groen, K; Gulati, RS; Horan, MA; Jansen, EJ; Miljkovic, B; Paramsothy, V; Roberts, NA; van Bezooijen, CF, 1993) |
| "The effect of post maturational aging on the in vivo disposition of theophylline was examined in the Mongolian gerbils (Meriones unguiculatus) aged 30-39 (old), 12-18 (middle-aged) and 3 (young) months following a 20 mg/kg i." | 3.68 | The effects of age on the pharmacokinetics and biotransformation of theophylline in vivo and in vitro in the Mongolian gerbil (Meriones unguiculatus). ( Lesko, L; McMahon, TF; Peggins, JO; Weiner, M, 1992) |
| "Fifty three subjects (31 normal volunteers and 22 patients with asthma) between the ages of 20 and 87 years had their theophylline clearance measured." | 3.67 | The relationship between theophylline clearance and age in adult life. ( Jackson, SH; Johnston, A; Turner, P; Woollard, R, 1989) |
| "Theophylline is commonly used to decrease airway resistance in patients with bronchopulmonary dysplasia (BPD)." | 3.67 | Theophylline pharmacokinetics in patients with bronchopulmonary dysplasia. ( Edwards, R; Nahata, MC; Serafini, D, 1989) |
| "On the assumption that plasma unbound drug concentrations are therapeutically active, the value of saliva concentrations in predicting plasma unbound theophylline concentrations was investigated in 25 ambulatory adults (aged 27 to 84 years) receiving theophylline (225-1350 mg aminophylline daily) for asthma or chronic bronchitis." | 3.67 | Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined. ( Bateman, M; Knott, C; Reynolds, F, 1984) |
| "The influence of age, sex and nutritional status on theophylline pharmacokinetics was studied in stable asthmatic children." | 3.67 | Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children. ( Garg, SK; Kumar, L; Lal, R; Shukla, VK; Singh, S, 1989) |
| "Analyses of 90 admissions to the Cincinnati Children's Hospital Center, Cincinnati, Ohio, were used to assess the effects of the routine availability of serum theophylline determinations (STD) in treating acute in-hospital asthma over three one-year review periods coinciding with the relative availability of STD." | 3.66 | Use of serum theophylline determinations during acute asthma therapy in children. ( Fischer, TJ; Hunter, RH; Kearns, GL, 1982) |
| "The influence of liver volume and body weight on plasma theophylline clearance was investigated in asthmatic children and adults." | 3.66 | Relationships between plasma theophylline clearance, liver volume and body weight in children and adults. ( Birkett, DJ; Goldin, A; Grygiel, JJ; Ogborne, M; Ward, H, 1983) |
| "Theophylline (T) tissue distribution was studied in 11 premature newborns treated with T for prematurity apnea, who had died from severe pathology." | 3.66 | Theophylline distribution in the premature neonate. ( Assael, BM; Bonati, M; Latini, R; Marra, G; Parini, R, 1981) |
| " Urine samples were collected for 24 h after dosing and analysed for caffeine and eleven of its metabolites by high-performance liquid chromatography." | 2.66 | Comparison of the urinary metabolite profile of caffeine in young and elderly males. ( Blanchard, J; Jonkman, JH; Sawers, SJ; Tang-Liu, DD, 1985) |
| " Especially when used in elderly asthmatic patients, dosage adjustment of theophylline is a requisite since the elderly have several risk factors that may increase the plasma theophylline level, such as reduced clearance, various underlying diseases and multiple coadministered drugs." | 2.42 | Differential pharmacokinetics of theophylline in elderly patients. ( Kato, M; Kawai, H; Kojima, J; Ohnishi, A; Ushiama, H; Yoneko, M, 2003) |
| "Children's risks can differ from those in adults for numerous reasons, one being differences in the pharmacokinetic handling of chemicals." | 2.42 | Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents. ( Ginsberg, G; Hattis, D; Russ, A; Sonawane, B, 2004) |
| "This tremor is normally recordable at a stable frequency of 8-10 Hz, though this can be influenced by age, the amplitude can vary substantially." | 2.39 | [Most frequent causes for hand tremor in clinical practice]. ( Málly, J, 1995) |
| "The risk of seizures secondary to the withdrawal of alcohol (ethanol) and benzodiazepines, and methods employed to minimise the risk are discussed." | 2.39 | Drug-induced seizures in the elderly. Causative agents and optimal management. ( Chatel, DM; Dahdal, WY; Franson, KL; Grossberg, GT; Hay, DP; Kotegal, S; Mirza, WU; Neppe, V; Szwabo, PA, 1995) |
| " When models were evaluated with validation data, a single-exponent model overpredicted clearance and dosing rate in premature neonates and adults with a mean prediction error of ≥50%." | 1.48 | Age- and Bodyweight-dependent Allometric Exponent Model for Scaling Clearance and Maintenance Dose of Theophylline From Neonates to Adults. ( Mahmood, I; Tegenge, MA, 2018) |
| "Although both POPPK and physiologically based pharmacokinetic (PBPK) models can account for age and other covariates within a paediatric population, they generally do not account for real-time growth and maturation of the individuals through the time course of drug exposure; this may be significant in prolonged neonatal studies." | 1.40 | Changes in individual drug-independent system parameters during virtual paediatric pharmacokinetic trials: introducing time-varying physiology into a paediatric PBPK model. ( Abduljalil, K; Jamei, M; Johnson, TN; Rostami-Hodjegan, A, 2014) |
| " Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants." | 1.35 | Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients. ( Igarashi, T; Iwakawa, S, 2009) |
| "To create a general physiologically based pharmacokinetic (PBPK) model for drug disposition in infants and children, covering the age range from birth to adulthood, and to evaluate it with theophylline and midazolam as model drugs." | 1.33 | Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs. ( Björkman, S, 2005) |
| " It also was noticed that young dogs have a slower elimination half-life (1 week old, t 1/2 beta = 987 minutes) than do older animals (8 weeks old, t 1/2 beta = 138 minutes)." | 1.29 | Effect of age on theophylline pharmacokinetics in dogs. ( Alberola, J; Arboix, M; Pérez, Y; Puigdemont, A, 1993) |
| "Theophylline is often used in infants, yet few studies have evaluated the serum concentrations achieved with currently recommended dosing guidelines." | 1.29 | Pharmacokinetic evaluation of two theophylline dosing methods for infants. ( Fischer, JH; Hatzopoulos, FK; Kraus, DM; Reitz, SJ, 1994) |
| " A theophylline dosage individualized to obtain a mean theophylline concentration in plasma of 10 +/- 3 micrograms/ml was administered for 1 week to each subject." | 1.28 | Safety of fleroxacin coadministered with theophylline to young and elderly volunteers. ( LeBel, M; Parent, M; St-Laurent, M, 1990) |
| "Dietary protein deficiency led to a significant reduction of total body clearance from approximately 73 to 45 ml/hr/kg in the 2 and 14 month old rats." | 1.28 | The effects of age and dietary protein restriction on the pharmacokinetics of theophylline in the rat. ( Jung, D; Nanavaty, M, 1990) |
| " A one-compartment pharmacokinetic model with first-order elimination was used, with intravenous aminophylline and oral theophylline administration modeled as zero-order infusions." | 1.28 | The population pharmacokinetics of theophylline in neonates and young infants. ( Banagale, RC; Faix, RG; Grasela, TH; Moore, ES, 1989) |
| " The results were opposite to other studies, probably because the dose and dosing intervals were different." | 1.28 | Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang. ( Chen, SM; Hou, SJ; Lin, SY; Perng, RI; Young, TK, 1992) |
| "When glycerol release was calculated as a percentage increase, the effects of these drugs became more marked with age." | 1.27 | Age related changes in the antilipolytic effects of nicotinic acid in rat adipose tissue. ( Caparrotta, L; Fassina, G; Gaion, RM; Tessari, F, 1983) |
| " We conclude that neither time of dosing nor age are important determinants of theophylline elimination kinetics in healthy subjects." | 1.27 | Effects of time of dosing and age on intravenous aminophylline pharmacokinetics. ( Bateman, DN; Rodgers, A; Woodhouse, KW, 1987) |
| " Drugs with flow-limited elimination or mainly oxidative phase I biotransformation should be administered with reduced dosage level while monitoring the serum concentration levels." | 1.27 | [The liver and aging. The effect of age on liver function and drug metabolism]. ( Femfert, U; Kuntz, HD; May, B, 1987) |
| "The pharmacokinetics of two unmatched populations of asthmatic children, one from an asthmatic convalescent center in Denver and the other from an urban outpatient clinic, are compared after single and repeated dosing of a new asthma formulation, oxtriphylline syrup." | 1.26 | Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup. ( Bell, T; Danish, M; Katsampes, C; Lecks, H; Ragni, M; Rasmussen, C; Simon, T; Yaffe, S, 1980) |
| " Rat pups were given either aminophylline, theophylline, or caffeine in a dosage of 40 mg/kg or 80 mg/kg daily from the second postnatal day through 20 days of age." | 1.26 | A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain. ( Fuller, GN; Wiggins, RC, 1981) |
| " Food significantly reduced the absorption rate of theophylline whereas the extent of absorption of theophylline was unaffected by food." | 1.26 | Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation. ( Moeller-Petersen, J; Pedersen, S, 1982) |
| "The biphasic nature of the lipolytic dose-response curve of epinephrine in fat cells from "young" rats (40-45 days) was confirmed." | 1.25 | Hormone-stimulated lipolysis in isolated fat cells from "young" and "old" rats. ( Allen, DO; Miller, EA, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 81 (57.04) | 18.7374 |
| 1990's | 43 (30.28) | 18.2507 |
| 2000's | 10 (7.04) | 29.6817 |
| 2010's | 7 (4.93) | 24.3611 |
| 2020's | 1 (0.70) | 2.80 |
| Authors | Studies |
|---|---|
| Duman, M | 1 |
| Vaquié, A | 1 |
| Nocera, G | 1 |
| Heller, M | 1 |
| Stumpe, M | 1 |
| Siva Sankar, D | 1 |
| Dengjel, J | 1 |
| Meijer, D | 1 |
| Yamaguchi, T | 1 |
| Matthias, P | 1 |
| Zeis, T | 1 |
| Schaeren-Wiemers, N | 1 |
| Hayoz, A | 1 |
| Ruff, S | 1 |
| Jacob, C | 1 |
| Tegenge, MA | 1 |
| Mahmood, I | 1 |
| Kuroda, Y | 1 |
| Taguchi, K | 1 |
| Enoki, Y | 1 |
| Matsumoto, K | 1 |
| Hori, S | 1 |
| Kizu, J | 1 |
| Al-Alawi, M | 1 |
| Hassan, T | 1 |
| Chotirmall, SH | 1 |
| Abduljalil, K | 1 |
| Jamei, M | 1 |
| Rostami-Hodjegan, A | 1 |
| Johnson, TN | 1 |
| Cutler, RG | 1 |
| Camandola, S | 1 |
| Malott, KF | 1 |
| Edelhauser, MA | 1 |
| Mattson, MP | 1 |
| Maharaj, AR | 1 |
| Edginton, AN | 1 |
| Sohn, JA | 1 |
| Kim, HS | 1 |
| Oh, J | 1 |
| Cho, JY | 1 |
| Yu, KS | 1 |
| Lee, J | 1 |
| Shin, SH | 1 |
| Lee, JA | 1 |
| Choi, CW | 1 |
| Kim, EK | 1 |
| Kim, BI | 1 |
| Park, EA | 1 |
| Igarashi, T | 1 |
| Iwakawa, S | 2 |
| Ohnishi, A | 1 |
| Kato, M | 1 |
| Kojima, J | 1 |
| Ushiama, H | 1 |
| Yoneko, M | 1 |
| Kawai, H | 1 |
| Ginsberg, G | 1 |
| Hattis, D | 1 |
| Russ, A | 1 |
| Sonawane, B | 1 |
| Sitar, DS | 1 |
| Nishihara, K | 1 |
| Björkman, S | 1 |
| Zimmer, MB | 1 |
| Goshgarian, HG | 1 |
| Sachse, KT | 1 |
| Jackson, EK | 1 |
| Wisniewski, SR | 1 |
| Gillespie, DG | 1 |
| Puccio, AM | 1 |
| Clark, RS | 1 |
| Dixon, CE | 1 |
| Kochanek, PM | 1 |
| Volpe, JJ | 1 |
| Bukowskyj, M | 1 |
| Nakatsu, K | 1 |
| Munt, PW | 1 |
| Benzi, G | 1 |
| Arrigoni, E | 1 |
| Dagani, F | 1 |
| Marzatico, F | 1 |
| Curti, D | 1 |
| Raimondo, S | 1 |
| Dossena, M | 1 |
| Polgatti, M | 1 |
| Villa, RF | 1 |
| Stancheva, S | 2 |
| Ammon, HP | 1 |
| Amm, U | 1 |
| Eujen, R | 1 |
| Hoppe, E | 1 |
| Trier, G | 1 |
| Verspohl, EJ | 1 |
| Caparrotta, L | 1 |
| Fassina, G | 1 |
| Gaion, RM | 1 |
| Tessari, F | 1 |
| Knott, C | 1 |
| Bateman, M | 1 |
| Reynolds, F | 1 |
| D'Souza, CA | 1 |
| Friesen, WT | 1 |
| von Witt, RJ | 1 |
| Taylor, GR | 1 |
| Roberts, MS | 1 |
| Ogilvie, RI | 1 |
| Besnard, P | 1 |
| Garel, JM | 1 |
| Kearns, GL | 1 |
| Fischer, TJ | 1 |
| Hunter, RH | 1 |
| Tserng, KY | 2 |
| Takieddine, FN | 2 |
| King, KC | 2 |
| Fox, RW | 1 |
| Samaan, S | 1 |
| Bukantz, SC | 1 |
| Lockey, RF | 1 |
| Grygiel, JJ | 1 |
| Ward, H | 1 |
| Ogborne, M | 1 |
| Goldin, A | 1 |
| Birkett, DJ | 1 |
| Palacios, R | 1 |
| Alarcón-Segovia, D | 1 |
| Llorente, L | 1 |
| Ruíz-Arguelles, A | 1 |
| Díaz-Jouanen, E | 1 |
| Denenberg, VH | 1 |
| Zeidner, LP | 1 |
| Thoman, EB | 1 |
| Kramer, P | 1 |
| Rowe, JC | 1 |
| Philipps, AF | 1 |
| Raye, JR | 1 |
| Jager-Roman, E | 1 |
| Doyle, PE | 1 |
| Thomas, D | 1 |
| Baird-Lambert, J | 1 |
| Cvejic, M | 1 |
| Buchanan, N | 2 |
| Pedersen, S | 1 |
| Moeller-Petersen, J | 1 |
| Fuller, GN | 1 |
| Wiggins, RC | 1 |
| Lloyd, HG | 1 |
| Stone, TW | 1 |
| Kalhan, SC | 1 |
| Bonati, M | 1 |
| Latini, R | 1 |
| Marra, G | 1 |
| Assael, BM | 1 |
| Parini, R | 1 |
| Bell, T | 1 |
| Yaffe, S | 1 |
| Lecks, H | 1 |
| Danish, M | 1 |
| Ragni, M | 1 |
| Simon, T | 1 |
| Rasmussen, C | 1 |
| Katsampes, C | 1 |
| Aldridge, A | 1 |
| Neims, AH | 1 |
| Málly, J | 1 |
| Yderstraede, KB | 1 |
| Flindt-Egebak, P | 1 |
| Franson, KL | 1 |
| Hay, DP | 1 |
| Neppe, V | 1 |
| Dahdal, WY | 1 |
| Mirza, WU | 1 |
| Grossberg, GT | 1 |
| Chatel, DM | 1 |
| Szwabo, PA | 1 |
| Kotegal, S | 1 |
| Groen, K | 2 |
| Breimer, DD | 2 |
| Brouwer, A | 1 |
| Schijff, G | 1 |
| Jansen, EJ | 2 |
| van Bezooijen, CF | 2 |
| Suteparuk, S | 1 |
| Nies, AS | 1 |
| Andros, E | 1 |
| Gerber, JG | 3 |
| Aguila-Mansilla, N | 1 |
| Kedzierski, W | 1 |
| Porter, JC | 1 |
| Marchetti, P | 1 |
| Scharp, DW | 1 |
| Finke, EH | 1 |
| Giannarelli, R | 1 |
| Swanson, CJ | 1 |
| Olack, BJ | 1 |
| Lacy, PE | 1 |
| Navalesi, R | 1 |
| Kraus, DM | 2 |
| Hatzopoulos, FK | 1 |
| Reitz, SJ | 2 |
| Fischer, JH | 2 |
| Coutinho, LL | 1 |
| Bergen, WG | 1 |
| Romsos, DR | 1 |
| Merkel, RA | 1 |
| Ueno, K | 1 |
| Tanaka, K | 1 |
| Shiokawa, M | 1 |
| Horiuchi, Y | 1 |
| Kecskes, SA | 1 |
| Yeh, TF | 1 |
| McCulloch, KM | 1 |
| Tung, EC | 1 |
| Cwik, MJ | 1 |
| Alberola, J | 1 |
| Pérez, Y | 1 |
| Puigdemont, A | 1 |
| Arboix, M | 1 |
| Horan, MA | 1 |
| Roberts, NA | 1 |
| Gulati, RS | 1 |
| Miljkovic, B | 1 |
| Paramsothy, V | 1 |
| Tanigawara, Y | 1 |
| Komada, F | 1 |
| Shimizu, T | 1 |
| Iwai, T | 1 |
| Maekawa, H | 1 |
| Hori, R | 1 |
| Okumura, K | 1 |
| Matherne, GP | 1 |
| Berr, SS | 1 |
| Headrick, JP | 1 |
| Elnazir, B | 1 |
| Marshall, JM | 1 |
| Kumar, P | 1 |
| Loi, CM | 1 |
| Parker, BM | 1 |
| Cusack, BJ | 3 |
| Vestal, RE | 3 |
| Jay, TR | 1 |
| Heald, KA | 1 |
| Downing, R | 1 |
| Yokoyama, H | 1 |
| Onodera, K | 1 |
| Yagi, T | 1 |
| Iinuma, K | 1 |
| Dumas, TC | 1 |
| Foster, TC | 1 |
| Snyder, DL | 1 |
| Wang, W | 1 |
| Pelleg, A | 1 |
| Friedman, E | 1 |
| Horwitz, J | 1 |
| Roberts, J | 1 |
| Andros, EA | 1 |
| Miller, EA | 1 |
| Allen, DO | 1 |
| Popoli, P | 1 |
| Reggio, R | 1 |
| Pèzzola, A | 1 |
| Fuxe, K | 1 |
| Ferré, S | 1 |
| Tateishi, T | 1 |
| Asoh, M | 1 |
| Yamaguchi, A | 1 |
| Yoda, T | 1 |
| Okano, YJ | 1 |
| Koitabashi, Y | 1 |
| Kobayashi, S | 1 |
| Detmar-Hanna, D | 1 |
| Zahniser, NR | 1 |
| Erlwanger, KH | 1 |
| Unmack, MA | 1 |
| Grøndahl, ML | 1 |
| Skadhauge, E | 2 |
| Thorbøll, JE | 1 |
| Imbeault, P | 2 |
| Prud'Homme, D | 1 |
| Tremblay, A | 2 |
| Després, JP | 2 |
| Mauriège, P | 2 |
| Vidal, H | 1 |
| Vega, N | 1 |
| Nadeau, A | 1 |
| Blair, JB | 1 |
| James, ME | 1 |
| Foster, JL | 1 |
| Jusko, WJ | 1 |
| Gardner, MJ | 1 |
| Mangione, A | 1 |
| Schentag, JJ | 1 |
| Koup, JR | 2 |
| Vance, JW | 1 |
| Reĭzin, FN | 1 |
| Roĭkhel', VM | 1 |
| Chumakov, MP | 1 |
| Claycomb, WC | 1 |
| Sartin, JL | 2 |
| Pritchett, JF | 2 |
| Marple, DN | 2 |
| Harper, WL | 1 |
| Till, ML | 1 |
| Gershman, H | 1 |
| Weis, G | 1 |
| Barstow, N | 1 |
| Petkov, V | 1 |
| Uzunov, P | 1 |
| Rhomberg, F | 1 |
| Cusack, B | 1 |
| Kelly, JG | 1 |
| Lavan, J | 1 |
| Noel, J | 1 |
| O'Malley, K | 1 |
| Herrschaft, H | 1 |
| Majerus, TC | 1 |
| Feroli, ER | 1 |
| Gross, I | 1 |
| Rane, A | 1 |
| Wilson, JT | 1 |
| Imamura, S | 1 |
| Kimura, M | 1 |
| Hiratsuka, E | 1 |
| Takao, A | 1 |
| Matsuoka, R | 1 |
| Lin, SY | 1 |
| Hou, SJ | 1 |
| Perng, RI | 1 |
| Chen, SM | 1 |
| Young, TK | 1 |
| Peggins, JO | 1 |
| McMahon, TF | 1 |
| Weiner, M | 1 |
| Lesko, L | 1 |
| Wang, LC | 1 |
| Jin, ZL | 1 |
| Lee, TF | 1 |
| Gribkoff, VK | 1 |
| Bauman, LA | 1 |
| Koga, T | 1 |
| Takata, Y | 1 |
| Kobayashi, K | 1 |
| Fujii, K | 1 |
| Nagao, T | 1 |
| Fujishima, M | 1 |
| Stancheva, SL | 1 |
| Alova, LG | 1 |
| Sato-Bigbee, C | 1 |
| Yu, RK | 1 |
| Coiro, V | 1 |
| Volpi, R | 1 |
| Cavazzini, U | 1 |
| Bertoni, P | 1 |
| Corradi, A | 1 |
| Bianconi, L | 1 |
| Davoli, C | 1 |
| Rossi, G | 1 |
| Chiodera, P | 1 |
| Labat, C | 1 |
| Braunstein, G | 1 |
| Brink, C | 1 |
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| Sievers, E | 1 |
| Oldigs, HD | 1 |
| Dörner, K | 1 |
| Schaub, J | 1 |
| Munkres, KD | 1 |
| Rabinovitch, A | 1 |
| Sumoski, WL | 1 |
| Jung, D | 1 |
| Nanavaty, M | 1 |
| McEwan, GT | 1 |
| Schousboe, B | 1 |
| Nielsen, CG | 1 |
| de la Cruz, J | 1 |
| Burón, I | 1 |
| Roncero, I | 2 |
| Kumar, L | 1 |
| Garg, SK | 1 |
| Singh, S | 1 |
| Lal, R | 1 |
| Shukla, VK | 1 |
| Stine, RJ | 1 |
| Marcus, RH | 1 |
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| Süverkrüp, R | 1 |
| von Berg, A | 1 |
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| Warwick, ZS | 1 |
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| Serafini, D | 1 |
| Edwards, R | 1 |
| Skopińska-Rózewska, E | 2 |
| Liszewska-Pfejfert, D | 1 |
| Małkowska-Zwierz, W | 1 |
| Pawińska, M | 2 |
| Polakowski, IJ | 2 |
| Wróblewski, T | 2 |
| Braaten, B | 1 |
| Madara, JL | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Attenuation of Myocardial Dysfunction by N-Acetylcysteine in Infants Undergoing Arterial Switch Procedure[NCT00374088] | Phase 2 | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Maximum serum creatinine over first 3 days postoperative. (NCT00374088)
Timeframe: 72 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | 0.99 |
| N-acetylcysteine | 0.74 |
Serial cardiac output was measured by thermodilution. The outcome of maximum decline in indexed cardiac output from 1 hour postoperative to lowest output within 24 hours postoperative was then calculated and compared between NAC and placebo groups. (NCT00374088)
Timeframe: 24 hours
| Intervention | L/min/m2 (Mean) |
|---|---|
| Placebo | 0.68 |
| N-acetylcysteine | 0.29 |
Total urine output over the first 24 hours postoperative (NCT00374088)
Timeframe: 24 hours
| Intervention | mL (Mean) |
|---|---|
| Placebo | 96 |
| N-acetylcysteine | 176 |
12 reviews available for theophylline and Aging
| Article | Year |
|---|---|
Advances in the diagnosis and management of asthma in older adults.
Topics: Administration, Inhalation; Age Factors; Age of Onset; Aged; Aging; Airway Resistance; Anti-Asthmati | 2014 |
The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders.
Topics: Aging; Animals; Caffeine; Dietary Supplements; Humans; Mammals; Neurodegenerative Diseases; Theobrom | 2015 |
Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aging; Child; Delayed-Action Preparations; Gas | 2016 |
Differential pharmacokinetics of theophylline in elderly patients.
Topics: Aged; Aging; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Dose-Response Relationship, Drug; Drug | 2003 |
Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents.
Topics: Adult; Aging; Caffeine; Environmental Exposure; Half-Life; Humans; Infant, Newborn; Liver; Metabolic | 2004 |
[Bronchodilator: theophylline].
Topics: Aging; Asthma; Biomarkers; Bronchodilator Agents; Dosage Forms; Drug Interactions; Drug Monitoring; | 2004 |
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
Monitoring plasma theophylline concentrations.
Topics: Aging; Asthma; Humans; Kinetics; Theophylline | 1980 |
[Most frequent causes for hand tremor in clinical practice].
Topics: Aged; Aged, 80 and over; Aging; Female; Hand; Humans; Hypokinesia; Male; Parkinson Disease; Posture; | 1995 |
Drug-induced seizures in the elderly. Causative agents and optimal management.
Topics: Aging; Anti-Bacterial Agents; Anti-Infective Agents; Anticonvulsants; Antidepressive Agents; Antipsy | 1995 |
Clinical pharmacology of theophylline.
Topics: Administration, Oral; Adolescent; Adult; Aging; Apnea; Arterioles; Biological Availability; Bronchia | 1979 |
Multihormonal regulation of hepatic histidase during postnatal development.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Aging; Ammonia-Lyases; Animals; Buclades | 1973 |
6 trials available for theophylline and Aging
| Article | Year |
|---|---|
Population pharmacokinetics of theophylline. III. Premarketing study for a once-daily administered preparation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Asthma; Bronchodilator Agen | 1995 |
The effect of adenosine on the reduced heart rate response to exercise in the elderly.
Topics: Adenosine; Aged; Aging; Anti-Arrhythmia Agents; Exercise Test; Heart Rate; Humans; Male; Middle Aged | 1998 |
Adipose tissue metabolism in young and middle-aged men after control for total body fatness.
Topics: Adipose Tissue; Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists; | 2000 |
Aminophylline loading in asthmatic patients: a protocol trial.
Topics: Adolescent; Adult; Aged; Aging; Aminophylline; Asthma; Body Weight; Clinical Trials as Topic; Emerge | 1989 |
Comparison of the urinary metabolite profile of caffeine in young and elderly males.
Topics: Adult; Aged; Aging; Caffeine; Glomerular Filtration Rate; Humans; Male; Random Allocation; Theobromi | 1985 |
[Mental effects of Wallerox therapy in the aged].
Topics: Aged; Aging; Bufanolides; Cerebrovascular Circulation; Cerebrovascular Disorders; Clinical Trials as | 1970 |
124 other studies available for theophylline and Aging
| Article | Year |
|---|---|
EEF1A1 deacetylation enables transcriptional activation of remyelination.
Topics: Acetylation; Aging; Animals; Cell Dedifferentiation; Cell Nucleus; Histone Deacetylase 1; Histone De | 2020 |
Age- and Bodyweight-dependent Allometric Exponent Model for Scaling Clearance and Maintenance Dose of Theophylline From Neonates to Adults.
Topics: Adult; Aging; Body Weight; Child; Child, Preschool; Drug Dosage Calculations; Female; Humans; Infant | 2018 |
Age-Associated Theophylline Metabolic Activity Corresponds to the Ratio of 1,3-Dimethyluric Acid to Theophylline in Mice.
Topics: Aging; Animals; Male; Mice, Inbred ICR; Theophylline; Uric Acid | 2019 |
Changes in individual drug-independent system parameters during virtual paediatric pharmacokinetic trials: introducing time-varying physiology into a paediatric PBPK model.
Topics: Aging; Anticonvulsants; Bronchodilator Agents; Child; Child, Preschool; Clinical Trials as Topic; Hu | 2014 |
Prediction of serum theophylline concentrations and cytochrome P450 1A2 activity by analyzing urinary metabolites in preterm infants.
Topics: Aging; Apnea; Bronchodilator Agents; Cytochrome P-450 CYP1A2; Female; Genotype; Gestational Age; Hum | 2017 |
Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients.
Topics: Acute Disease; Aging; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Child; Child, Prescho | 2009 |
Old drugs - old people - new insights.
Topics: Aging; Humans; Morphine; Pharmaceutical Preparations; Pharmacology, Clinical; Propylthiouracil; Theo | 2005 |
Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs.
Topics: Adolescent; Aging; Body Composition; Bronchodilator Agents; Cardiac Output; Child; Child, Preschool; | 2005 |
Spontaneous crossed phrenic activity in the neonatal respiratory network.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Brain Stem; Bronchodilator Agents; Efferent Pat | 2005 |
Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.
Topics: Adult; Aging; Brain Injuries; Caffeine; Central Nervous System Depressants; Central Nervous System S | 2008 |
Effects of methylxanthines on lipid synthesis in developing neural systems.
Topics: Acetyl-CoA Carboxylase; Aging; Aminophylline; Brain; Caffeine; Cell Division; Cell Line; Cholesterol | 1981 |
Age-dependent modification of drug interference on the enzymatic activities of the rat brain.
Topics: Age Factors; Aging; Animals; Brain; Cytidine Diphosphate Choline; Dihydroergotoxine; Male; Nicergoli | 1980 |
Pharmacological and biochemical study in ontogenetic aspect of 3'-5'-adenosinemonophosphate phosphodiesterases with low and high Km.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Animals, Newborn; Brain; Ileum; Isoenzymes; Kin | 1981 |
The role of old age in the effects of glucose on insulin secretion, pentosephosphate shunt activity, pyridine nucleotides and glutathione of rat pancreatic islets.
Topics: Aging; Animals; DNA; Female; Glucose; Glucose Tolerance Test; Glutathione; In Vitro Techniques; Insu | 1984 |
Age related changes in the antilipolytic effects of nicotinic acid in rat adipose tissue.
Topics: Adipose Tissue; Aging; Animals; Fatty Acids, Nonesterified; Glycerol; In Vitro Techniques; Lipolysis | 1983 |
Do saliva concentrations predict plasma unbound theophylline concentrations? A problem re-examined.
Topics: Adult; Aged; Aging; Asthma; Blood Proteins; Bronchitis; Child; Child, Preschool; Female; Humans; Inf | 1984 |
An audit of therapeutic drug monitoring procedures--use of theophylline assay services.
Topics: Adult; Aging; Australia; Chemistry, Clinical; Drug Therapy, Combination; Drug Utilization; Hospital | 1984 |
[Perifusion study of the secretion of calcitonin in the young rat: effect of isoproterenol and theophylline].
Topics: Aging; Animals; Calcitonin; Isoproterenol; Rats; Theophylline; Thyroid Gland | 1981 |
Use of serum theophylline determinations during acute asthma therapy in children.
Topics: Acute Disease; Adolescent; Adult; Aging; Analysis of Variance; Asthma; Child; Child, Hospitalized; C | 1982 |
Developmental aspects of theophylline metabolism in premature infants.
Topics: Aging; Gas Chromatography-Mass Spectrometry; Gestational Age; Humans; Infant, Newborn; Infant, Prema | 1983 |
Theophylline kinetics in a geriatric group.
Topics: Adult; Aged; Aging; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Middle Aged; Regres | 1983 |
Relationships between plasma theophylline clearance, liver volume and body weight in children and adults.
Topics: Adult; Aging; Body Weight; Child; Child, Preschool; Female; Humans; Liver; Male; Middle Aged; Organ | 1983 |
Human post-thymic precursor cells in health and disease. I. Characterization of the autologous rosette-forming T cells as post-thymic precursors.
Topics: Adult; Aged; Aging; Feedback; Fetal Blood; Humans; Hydrocortisone; Immune Tolerance; Immunoglobulin | 1981 |
Effects of theophylline on behavioral state development in the newborn rabbit.
Topics: Aging; Animals; Animals, Newborn; Arousal; Behavior, Animal; Body Weight; Exploratory Behavior; Kine | 1982 |
Increased theophylline metabolism in premature infants after prenatal betamethasone administration.
Topics: Aging; Betamethasone; Birth Weight; Dealkylation; Female; Gestational Age; Half-Life; Humans; Infant | 1982 |
Influence of food on the absorption rate and bioavailability of a sustained release theophylline preparation.
Topics: Adult; Aging; Asthma; Biological Availability; Child; Delayed-Action Preparations; Dose-Response Rel | 1982 |
A possible effect of the methylxanthines caffeine, theophylline and aminophylline on postnatal myelination of the rat brain.
Topics: Aging; Aminophylline; Animals; Body Weight; Brain; Caffeine; Intracellular Membranes; Myelin Sheath; | 1981 |
Chronic methylxanthine treatment in rats: a comparison of Wistar and Fischer 344 strains.
Topics: Aging; Aminophylline; Animals; Behavior, Animal; Caffeine; Diet; Rats; Rats, Inbred F344; Sex Factor | 1981 |
Postnatal development of theophylline metabolism in preterm infants.
Topics: Adult; Aging; Child; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; | 1981 |
Theophylline distribution in the premature neonate.
Topics: Aging; Animals; Animals, Newborn; Apnea; Blood-Brain Barrier; Female; Gestational Age; Guinea Pigs; | 1981 |
Theophylline pharmacokinetics: variations between two similar study populations using oral oxtriphylline syrup.
Topics: Administration, Oral; Aging; Body Height; Body Weight; Child; Choline; Female; Humans; Kinetics; Mal | 1980 |
Relationship between the clearance of caffeine and its 7-N-demethylation in developing beagle puppies.
Topics: Aging; Animals; Caffeine; Dealkylation; Dogs; Female; Kinetics; Theobromine; Theophylline; Xanthines | 1980 |
Neonatal rat islets of Langerhans and fetal rat pancreas. Isolation, immunohistochemical, functional, and autoradiographic evaluation.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cell Separation; Cells, Cultured; Centrifugation, | 1995 |
The influence of dietary restriction on the metabolism of theophylline and antipyrine in the ageing female BN/BiRij rat.
Topics: Aging; Animals; Antipyrine; Cytochrome P-450 Enzyme System; Energy Intake; Female; Rats; Theophyllin | 1995 |
The role of adenosine in promoting cardiac beta-adrenergic subsensitivity in aging humans.
Topics: Adenosine; Adult; Aged; Aging; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rate; | 1995 |
Localization of a defect in hypothalamic dopaminergic neurons of the aged brain that results in impaired PKA-dependent activation of tyrosine hydroxylase.
Topics: Aging; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enzyme Activa | 1993 |
Factors affecting in vitro and in vivo function of isolated porcine islets.
Topics: Aging; Animals; Blood Glucose; Cryopreservation; Culture Techniques; Diabetes Mellitus, Experimental | 1994 |
Pharmacokinetic evaluation of two theophylline dosing methods for infants.
Topics: Aging; Biological Availability; Evaluation Studies as Topic; Humans; Infant; Retrospective Studies; | 1994 |
Alpha-2 adrenergic receptor activity in porcine adipocytes is androgen and age/cell size dependent.
Topics: Adipose Tissue; Aging; Androgens; Animals; Cell Size; Epinephrine; Isoproterenol; Lipolysis; Male; P | 1993 |
Age-dependent changes of renal excretion of theophylline in asthmatic children.
Topics: Administration, Oral; Aging; Asthma; Bronchitis; Child, Preschool; Chronic Disease; Delayed-Action P | 1994 |
Alterations in theophylline metabolism during the first year of life.
Topics: Aging; Analysis of Variance; Caffeine; Humans; Infant; Infant, Newborn; Linear Models; Metabolic Cle | 1993 |
Effect of age on theophylline pharmacokinetics in dogs.
Topics: Aging; Animals; Body Weight; Chromatography, High Pressure Liquid; Dogs; Half-Life; Male; Metabolic | 1993 |
The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antipyrine; Chromatography, High Pressure Liquid; Female; Fra | 1993 |
Integration of vascular, contractile and metabolic responses to hypoxia: effects of maturation and adenosine.
Topics: Adenosine; Aging; Animals; Coronary Circulation; Coronary Vessels; Energy Metabolism; Heart; Hemodyn | 1996 |
Postnatal development of the pattern of respiratory and cardiovascular response to systemic hypoxia in the piglet: the roles of adenosine.
Topics: 2-Chloroadenosine; Adenosine; Aging; Animals; Animals, Newborn; Cardiovascular System; Hypoxia; Resp | 1996 |
Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers.
Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Biotransformation; Cimetidine; Ciprofloxacin; | 1997 |
Effect of donor age on porcine insulin secretion.
Topics: Aging; Animals; Carbachol; Cells, Cultured; Glucose; Insulin; Insulin Secretion; Islets of Langerhan | 1997 |
Therapeutic doses of theophylline exert proconvulsant effects in developing mice.
Topics: Aging; Animals; Anticonvulsants; Bronchodilator Agents; Dose-Response Relationship, Drug; Electrosho | 1997 |
Late developmental changes in the ability of adenosine A1 receptors to regulate synaptic transmission in the hippocampus.
Topics: Aging; Animals; Calcium; Colforsin; Excitatory Postsynaptic Potentials; Extracellular Space; Hippoca | 1998 |
Effect of aging on A1-adenosine receptor-mediated inhibition of norepinephrine release in the rat heart.
Topics: Adenosine; Adenosine Deaminase; Aging; Animals; Heart; Male; Myocardium; Norepinephrine; Rats; Rats, | 1998 |
Hormone-stimulated lipolysis in isolated fat cells from "young" and "old" rats.
Topics: Adipocytes; Adrenocorticotropic Hormone; Aging; Animals; Dose-Response Relationship, Drug; Epinephri | 1973 |
Adenosine A1 and A2A receptor antagonists stimulate motor activity: evidence for an increased effectiveness in aged rats.
Topics: Aging; Animals; Male; Motor Activity; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, W | 1998 |
Developmental changes in urinary elimination of theophylline and its metabolites in pediatric patients.
Topics: Aging; Apnea; Asthma; Child, Preschool; Cytochrome P-450 CYP1A2; Humans; Infant; Infant, Newborn; Th | 1999 |
Lack of an effect of age on beta-adrenoceptor-mediated lipolysis in isolated human adipocytes.
Topics: Adipocytes; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; A | 1999 |
Effect of age on vasoactive intestinal polypeptide-induced short-circuit current in porcine jejunum.
Topics: Aging; Animals; Jejunum; Membrane Potentials; Swine; Theophylline; Vasoactive Intestinal Peptide | 1999 |
Age-related differences in messenger ribonucleic acid expression of key proteins involved in adipose cell differentiation and metabolism.
Topics: Abdomen; Adipocytes; Adipose Tissue; Adult; Aging; Bucladesine; Canada; Cell Differentiation; Colfor | 2001 |
Adrenergic control of glucose output and adenosine 3':5'-monophosphate levels in hepatocytes from juvenile and adult rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aging; Animals; Cyclic AMP; Epinephrine; | 1979 |
Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol.
Topics: Adult; Aging; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Cannabis; Contraceptives, Oral, Ho | 1979 |
[Effect on drugs changing the intracellular level of adenosine 3',5'-cyclic monophosphate on interferon formation in chick embryo cells of different ages].
Topics: Aging; Animals; Cells, Cultured; Chick Embryo; Cyclic AMP; Depression, Chemical; Dose-Response Relat | 1975 |
Biochemical aspects of cardiac muscle differentiation. Possible control of deoxyribonucleic acid synthesis and cell differentiation by adrenergic innervation and cyclic adenosine 3':5'-monophosphate.
Topics: Aging; Animals; Animals, Newborn; Bucladesine; Cell Differentiation; Cyclic AMP; Cyclic GMP; DNA Rep | 1976 |
TSH, theophylline and cyclic AMP: in vitro thyroid activity in aging rats.
Topics: Aging; Animals; Cyclic AMP; In Vitro Techniques; Male; Rats; Theophylline; Thyroid Gland; Thyrotropi | 1977 |
Interaction of aging with in vitro adrenocortical responsiveness to ACTH and cyclic AMP.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aging; Animals; Corticosterone; Cyclic AMP; Male; Rats; | 1979 |
Dibutyryl cyclic AMP suppresses mobility of embryonic chick heart cells in aggregates.
Topics: Aging; Animals; Bucladesine; Cell Aggregation; Cell Movement; Cells, Cultured; Chick Embryo; Depress | 1979 |
Ontogenetic development of 3,5-adenosine monophosphate phosphodiesterase in guinea pig and rat ileum.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Animals, Newborn; Guinea Pigs; Ileum; Kinetics; | 1979 |
[General medical concepts for the dental treatment of aging patients].
Topics: Aged; Aging; Asthma; Cardiovascular Diseases; Cortisone; Dietary Carbohydrates; Emergencies; Geriatr | 1977 |
The effect of age and smoking on theophylline kinetics [proceedings].
Topics: Adult; Aged; Aging; Humans; Kinetics; Smoking; Theophylline | 1979 |
[Can drugs improve the blood supply of the brain? The question of use of so-called vasoactive and metabolic substances in brain arteriosclerosis].
Topics: Aging; Arteriosclerosis; Brain Diseases; Cerebrovascular Circulation; Humans; Oxygen Consumption; Th | 1977 |
Pharmacokinetics of theophylline therapy.
Topics: Aged; Aging; Humans; Kinetics; Theophylline | 1977 |
Nutritional and hormonal influences on lung phospholipid metabolism.
Topics: Adrenal Cortex Hormones; Aging; Animal Nutritional Physiological Phenomena; Animals; Fetus; Insulin; | 1977 |
Clinical pharmacokinetics in infants and children.
Topics: Aging; Body Water; Carbamazepine; Child; Child, Preschool; Clindamycin; Dextropropoxyphene; Diazoxid | 1976 |
Effect of caffeine on expression of cardiac myosin heavy chain gene in adult hypothyroid and fetal rats.
Topics: Aging; Animals; Caffeine; Cyclic AMP; Fetal Heart; Fetus; Gene Expression; Hypothyroidism; Myocardiu | 1992 |
Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang.
Topics: Aging; Aminophylline; Animals; Biological Availability; Cimetidine; Cytochrome P-450 Enzyme System; | 1992 |
The effects of age on the pharmacokinetics and biotransformation of theophylline in vivo and in vitro in the Mongolian gerbil (Meriones unguiculatus).
Topics: Aging; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Female; Gerbillinae; Half-Life; I | 1992 |
Decrease in cold tolerance of aged rats caused by the enhanced endogenous adenosine activity.
Topics: Adenosine; Adenosine Deaminase; Adipose Tissue; Aging; Animals; Body Temperature Regulation; Cold Te | 1992 |
Endogenous adenosine contributes to hypoxic synaptic depression in hippocampus from young and aged rats.
Topics: Adenosine; Aging; Animals; Cell Hypoxia; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; | 1992 |
Age-related changes in P2-purinergic receptors on vascular smooth muscle and endothelium.
Topics: Adenosine Triphosphate; Aging; Animals; Aorta; Dose-Response Relationship, Drug; Endothelium, Vascul | 1992 |
Age-related changes of cyclic AMP phosphodiesterase activity in rat brain regions and a new phosphodiesterase inhibitor--nootropic agent adafenoxate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Animals; Brain; Cyclic AMP; Kinetics; Meclofenoxate; Ner | 1991 |
Phosphorylation of nuclear proteins in myelinating oligodendrocytes and its control by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Aging; Animals; Brain; Cyclic AMP; Kinetics; Mo | 1991 |
Restoration of normal growth hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline.
Topics: Adult; Aged; Aging; Fatty Acids, Nonesterified; Growth Hormone; Growth Hormone-Releasing Hormone; Hu | 1991 |
Isoproterenol activation of prostaglandin production in guinea-pig airway muscle preparations from immature and mature animals.
Topics: Aging; Animals; Bronchi; Dinoprost; Dinoprostone; Enzyme Activation; Guinea Pigs; Histamine; Isoprot | 1991 |
Safety of fleroxacin coadministered with theophylline to young and elderly volunteers.
Topics: Adult; Aged; Aging; Anti-Infective Agents; Ciprofloxacin; Drug Therapy, Combination; Fleroxacin; Hum | 1990 |
Urinary zinc excretion in infancy.
Topics: Aging; Caffeine; Fetus; Humans; Infant Food; Infant, Newborn; Male; Milk, Human; Reproducibility of | 1990 |
Pharmacogenetics of cyclic guanylate, antioxidants, and antioxidant enzymes in Neurospora.
Topics: Aging; Antioxidants; Cell Differentiation; Culture Media; Cyclic GMP; Free Radicals; Gene Expression | 1990 |
Theophylline protects against diabetes in BB rats and potentiates cyclosporine protection.
Topics: Aging; Animals; Blood Glucose; Cyclosporins; Diabetes Mellitus, Experimental; Drug Synergism; Female | 1990 |
The effects of age and dietary protein restriction on the pharmacokinetics of theophylline in the rat.
Topics: Aging; Animals; Body Weight; Kwashiorkor; Liver; Male; Oxidation-Reduction; Protein Deficiency; Rats | 1990 |
Effect of age on the secretory capacity of pig small intestine in vivo and in vitro.
Topics: Aging; Animals; Chlorides; Cholera Toxin; Dinoprostone; Electric Conductivity; Electrophysiology; Il | 1990 |
Morphological and functional studies during aging at mitochondrial level. Action of drugs.
Topics: Adenosine Triphosphate; Aging; Animals; Calcitonin; Calcium; Female; Male; Mitochondria, Liver; Oxyg | 1990 |
Theophylline pharmacokinetics in well-nourished and malnourished asthmatic children.
Topics: Adolescent; Aging; Asthma; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Ha | 1989 |
The population pharmacokinetics of theophylline in neonates and young infants.
Topics: Aging; Female; Humans; Infant; Infant, Newborn; Male; Models, Biological; Population; Regression Ana | 1989 |
Renal clearance of theophylline and its major metabolites: age and urine flow dependency in paediatric patients.
Topics: Adolescent; Aging; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenous; Male; T | 1989 |
Use of flavor-amplified foods to improve nutritional status in elderly patients.
Topics: Aged; Aging; Amiloride; Bretylium Tosylate; Caffeine; Flavoring Agents; Humans; Inosine; Inosine Mon | 1989 |
Theophylline pharmacokinetics in patients with bronchopulmonary dysplasia.
Topics: Aging; Bronchopulmonary Dysplasia; Humans; Infant; Infant, Newborn; Theophylline | 1989 |
[Subpopulations of t lymphocytes in patients with ischemic heart disease].
Topics: Adult; Aged; Aged, 80 and over; Aging; Coronary Disease; Humans; Middle Aged; Rosette Formation; T-L | 1989 |
Age-related loss of nongoblet crypt cells parallels decreased secretion in rabbit descending colon.
Topics: Aging; Algorithms; Amiloride; Animals; Barium; Colon; Cyclic AMP; Electrolytes; Intestinal Absorptio | 1988 |
Mechanisms for colonic sodium transport during ontogeny: loss of an amiloride-sensitive sodium pathway.
Topics: Aging; Amiloride; Animals; Animals, Suckling; Biological Transport; Bucladesine; Colon; Cyclic AMP; | 1988 |
First phase of insulin secretion stimulated by glucose plus theophylline and inhibitory effect of somatostatin in genetically diabetic mice (C57BL/KsJ-mdb).
Topics: Aging; Animals; Diabetes Mellitus, Experimental; Female; Genetic Carrier Screening; Glucose; Homozyg | 1988 |
The relationship between theophylline clearance and age in adult life.
Topics: Adult; Aged; Aged, 80 and over; Aging; Asthma; Female; Half-Life; Humans; Male; Metabolic Clearance | 1989 |
Ribavirin influence on theophylline plasma levels in adult and children.
Topics: Aged; Aging; Child; Delayed-Action Preparations; Drug Interactions; Female; Humans; Immunoenzyme Tec | 1988 |
Melanocyte-stimulating hormone and the regulation of tyrosinase activity in hair follicular melanocytes of the mouse.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aging; Animals; Catechol Oxidase; Female; Hair; Hair Color; | 1986 |
Effect of age on neurotoxicity of theophylline.
Topics: Aging; Animals; Male; Nervous System Diseases; Rats; Rats, Inbred F344; Theophylline | 1988 |
Theophylline pharmacokinetics in normal elderly subjects.
Topics: Adult; Aged; Aging; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Male; Theo | 1988 |
Aging and drug interactions. II. Effect of phenytoin and smoking on the oxidation of theophylline and cortisol in healthy men.
Topics: Adult; Aged; Aging; Half-Life; Humans; Hydrocortisone; Male; Oxidation-Reduction; Phenytoin; Smoking | 1988 |
Effects of aging on respiration, ATP levels and calcium transport in rat liver mitochondria. Response to theophylline.
Topics: Adenosine Triphosphate; Aging; Animals; Biological Transport, Active; Calcium; Female; In Vitro Tech | 1988 |
Theophylline-resistant and theophylline-sensitive "early" and "late" E rosette-forming cells in young and aged humans.
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Antibodies, Monoclonal; Antigens, Surface; Arteriosc | 1987 |
Effects of time of dosing and age on intravenous aminophylline pharmacokinetics.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aminophylline; Circadian Rhythm; Female; Humans; Kinetics; Ma | 1987 |
Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Drug Interactions; Half-Life; Humans; Hydrocortis | 1987 |
[The liver and aging. The effect of age on liver function and drug metabolism].
Topics: Adult; Aged; Aging; Biotransformation; Female; Galactosemias; Half-Life; Humans; Hymecromone; Indocy | 1987 |
Ion transport by neonatal rabbit distal colon.
Topics: Aging; Amiloride; Animals; Animals, Newborn; Biological Transport; Chlorides; Colon; Electric Conduc | 1986 |
Rational theophylline use in older asthmatics.
Topics: Absorption; Aged; Aging; Anti-Bacterial Agents; Asthma; Drug Interactions; Female; Humans; Kinetics; | 1986 |
The relationship between clearance of theophylline and age within the adult age range.
Topics: Adolescent; Adult; Aging; Humans; Immunoenzyme Techniques; Kinetics; Metabolic Clearance Rate; Middl | 1985 |
Theophylline kinetics in chronic obstructive airway disease in the elderly.
Topics: Aged; Aging; Analysis of Variance; Carbon Dioxide; Half-Life; Humans; Hydrogen-Ion Concentration; In | 1985 |
Ozone-induced inhibition of theophylline elimination in rabbits: effect of age and sex.
Topics: Aging; Animals; Female; Half-Life; Male; Ozone; Rabbits; Sex Factors; Theophylline | 1985 |
The long-term regulation of tyrosine hydroxylase activity in cultured sympathetic ganglia: role of ganglionic noradrenaline content.
Topics: Acetylesterase; Aging; Animals; Animals, Newborn; Bucladesine; Carbachol; Choline; Cyclic AMP; Cyclo | 1974 |
Effect of age on norepinephrine-, ACTH-, theophylline- and dibutryl cyclic AMP-induced lipolysis in isolated rat fat cells.
Topics: Adenine Nucleotides; Adipose Tissue; Adrenocorticotropic Hormone; Aging; Animals; Dexamethasone; Lip | 1971 |
Insulin secretion during development: response of isolated pancreatic islets of fetal, newborn and adult rats to theophylline and arginine.
Topics: Aging; Animals; Animals, Newborn; Antigens; Arginine; Female; Fetus; Glucose; Immunoassay; In Vitro | 1972 |
Studies of glucagon resistance in large rat adipocytes: 125I-labeled glucagon binding and lipolytic capacity.
Topics: Adipose Tissue; Aging; Animals; Bucladesine; Epididymis; Epinephrine; Glucagon; Glycerol; Insulin; I | 1974 |
Dibutyryl cyclic adenosine 3',5-monophosphate and brain lipid metabolism.
Topics: Acetates; Aging; Animals; Brain; Bucladesine; Carbon Radioisotopes; Cerebrosides; Cesium; Cholestero | 1974 |
Adenyl cyclase in the pectoral muscle of normal chickens and chickens with hereditary muscular dystrophy.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Aging; Animals; Chick Embryo; Chickens; Fluo | 1972 |
[The influence of instenon on creative mental functions during aging (author's transl)].
Topics: Aged; Aging; Benzamides; Benzoates; Cerebrovascular Circulation; Creativity; Drug Combinations; Emot | 1974 |
Special problems in respiratory diseases.
Topics: Adrenal Cortex Hormones; Aged; Aging; Anti-Bacterial Agents; Anticoagulants; Asthma; Bronchodilator | 1974 |
Comparison of lipolysis in human subcutaneous and omental adipose tissue with regard to effects of noradrenaline, theophylline, prostaglandin E1 and age.
Topics: Adipose Tissue; Adolescent; Adult; Aged; Aging; Fatty Acids, Nonesterified; Female; Glycerol; Humans | 1969 |
The effect of theophylline and adrenaline on the lipolytic response of rats of different age.
Topics: Adipose Tissue; Aging; Animals; Epinephrine; Fatty Acids, Nonesterified; Glycerol; Lipid Metabolism; | 1970 |
Insulin secretion in mice with an hereditary diabetes.
Topics: Aging; Animals; Blood Glucose; Diabetes Mellitus; Female; Glucose; Insulin; Insulin Secretion; Mice; | 1968 |
[The aging heart and its treatment in general practice].
Topics: Aged; Aging; Coronary Disease; Humans; Plants, Medicinal; Theophylline | 1965 |